CSGALNACT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of phagocytosis (GO:0050765)5.56249908
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.19711529
3negative regulation of interleukin-12 production (GO:0032695)4.57131444
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36840158
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36840158
6negative regulation of cell killing (GO:0031342)4.30802918
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30802918
8definitive hemopoiesis (GO:0060216)4.29105949
9neutrophil mediated immunity (GO:0002446)4.25679189
10macrophage activation involved in immune response (GO:0002281)4.01786536
11regulation of T-helper 2 cell differentiation (GO:0045628)3.99520043
12detection of molecule of bacterial origin (GO:0032490)3.93895088
13Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90761903
14antigen processing and presentation of endogenous antigen (GO:0019883)3.87266638
15detection of other organism (GO:0098543)3.82825304
16neutrophil activation involved in immune response (GO:0002283)3.82180499
17ribosomal small subunit assembly (GO:0000028)3.77385328
18response to fungus (GO:0009620)3.71145401
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69153672
20sequestering of metal ion (GO:0051238)3.66427965
21negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.54269899
22negative regulation of T-helper cell differentiation (GO:0045623)3.54269899
23defense response to fungus (GO:0050832)3.53510350
24pinocytosis (GO:0006907)3.51450972
25detection of external biotic stimulus (GO:0098581)3.46663289
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.46286545
27killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.45918847
28disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.45918847
29regulation of gamma-delta T cell activation (GO:0046643)3.43034055
30myeloid leukocyte mediated immunity (GO:0002444)3.40923918
31positive regulation of gamma-delta T cell activation (GO:0046645)3.39869871
32detection of bacterium (GO:0016045)3.39863268
33respiratory burst (GO:0045730)3.37450615
34regulation of vitamin D biosynthetic process (GO:0060556)3.36791570
35necroptotic process (GO:0070266)3.36778920
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34169822
37response to peptidoglycan (GO:0032494)3.34036357
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.32077225
39regulation of B cell receptor signaling pathway (GO:0050855)3.31518211
40negative regulation of erythrocyte differentiation (GO:0045647)3.31426582
41regulation of T-helper 1 cell differentiation (GO:0045625)3.27611376
42response to host immune response (GO:0052572)3.26337831
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26337831
44negative regulation of type 2 immune response (GO:0002829)3.23935177
45macrophage differentiation (GO:0030225)3.22974489
46positive regulation of natural killer cell differentiation (GO:0032825)3.22615778
47modulation of growth of symbiont involved in interaction with host (GO:0044144)3.22607981
48regulation of growth of symbiont in host (GO:0044126)3.22607981
49negative regulation of growth of symbiont in host (GO:0044130)3.22607981
50negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.22607981
51germinal center formation (GO:0002467)3.22053763
52neutrophil activation (GO:0042119)3.21381553
53macrophage activation (GO:0042116)3.20724229
54positive regulation of mast cell activation (GO:0033005)3.20305871
55response to host (GO:0075136)3.17172393
56response to host defenses (GO:0052200)3.17172393
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.17172393
58detection of biotic stimulus (GO:0009595)3.16113922
59keratan sulfate catabolic process (GO:0042340)3.15027862
60negative regulation of interleukin-17 production (GO:0032700)3.11914132
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11870067
62leukotriene metabolic process (GO:0006691)3.11706088
63positive regulation of B cell differentiation (GO:0045579)3.07472187
64actin nucleation (GO:0045010)3.06511602
65regulation of leukocyte degranulation (GO:0043300)3.02199068
66myeloid cell activation involved in immune response (GO:0002275)3.00757690
67cellular response to zinc ion (GO:0071294)2.99678860
68angiogenesis involved in wound healing (GO:0060055)2.99457458
69regulation of necroptotic process (GO:0060544)2.97644245
70regulation of tolerance induction (GO:0002643)2.96777172
71positive regulation of cellular amide metabolic process (GO:0034250)2.96085100
72immunoglobulin mediated immune response (GO:0016064)2.95432525
73leukocyte aggregation (GO:0070486)2.94962889
74microglial cell activation (GO:0001774)2.93640534
75blood vessel maturation (GO:0001955)2.92964005
76negative regulation of T cell mediated immunity (GO:0002710)2.92823314
77defense response to protozoan (GO:0042832)2.92774455
78antigen processing and presentation via MHC class Ib (GO:0002475)2.92755771
79regulation of macrophage cytokine production (GO:0010935)2.92692888
80regulation of T cell tolerance induction (GO:0002664)2.92216680
81positive regulation of mast cell degranulation (GO:0043306)2.88863132
82positive regulation of mast cell activation involved in immune response (GO:0033008)2.88863132
83positive regulation of leukocyte degranulation (GO:0043302)2.84081721
84regulation of mast cell activation (GO:0033003)2.83806507
85production of molecular mediator involved in inflammatory response (GO:0002532)2.81904434
86response to protozoan (GO:0001562)2.81850567
87regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.81408595
88regulation of type 2 immune response (GO:0002828)2.81249797
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79791701
90granulocyte activation (GO:0036230)2.79347745
91positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.79295658
92reactive oxygen species biosynthetic process (GO:1903409)2.79178442
93regulation of gamma-delta T cell differentiation (GO:0045586)2.77126823
94programmed necrotic cell death (GO:0097300)2.75318245
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74915079
96megakaryocyte development (GO:0035855)2.73509337
97negative regulation of lymphocyte mediated immunity (GO:0002707)2.73317071
98negative regulation of cytokine production involved in immune response (GO:0002719)2.72908152
99regulation of B cell differentiation (GO:0045577)2.72420366
100positive regulation of tolerance induction (GO:0002645)2.70734667
101leukocyte mediated cytotoxicity (GO:0001909)2.68415459
102tolerance induction (GO:0002507)2.68212664
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67975469
104positive regulation by symbiont of host defense response (GO:0052509)2.67308808
105modulation by symbiont of host defense response (GO:0052031)2.67308808
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.67308808
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.67308808
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.67308808
109modulation by symbiont of host immune response (GO:0052553)2.67308808
110positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67295346
111myeloid dendritic cell activation (GO:0001773)2.66665149
112regulation of mast cell degranulation (GO:0043304)2.66207785
113superoxide anion generation (GO:0042554)2.65817187
114neutrophil chemotaxis (GO:0030593)2.65509440
115T-helper 1 type immune response (GO:0042088)2.64642153
116peptide catabolic process (GO:0043171)2.64621747
117negative regulation of mast cell activation (GO:0033004)2.63536986
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.62664722
119negative regulation of interleukin-6 production (GO:0032715)2.61398572
120cellular response to thyroid hormone stimulus (GO:0097067)2.61319243
121regulation of natural killer cell differentiation (GO:0032823)2.60979595
122regulation of interleukin-17 production (GO:0032660)2.60788733
123myeloid dendritic cell differentiation (GO:0043011)2.60220387
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59460706
125cellular extravasation (GO:0045123)2.59395694
126interferon-gamma-mediated signaling pathway (GO:0060333)2.59346635
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59222454
128positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58254210
129neutrophil migration (GO:1990266)2.58217265
130myeloid leukocyte activation (GO:0002274)2.57085671
131heparin metabolic process (GO:0030202)2.57036784
132heparin biosynthetic process (GO:0030210)2.57036784
133regulation of mast cell activation involved in immune response (GO:0033006)2.56708164
134positive regulation of chemokine biosynthetic process (GO:0045080)2.55164558
135surfactant homeostasis (GO:0043129)2.55070665
136negative regulation of leukocyte mediated immunity (GO:0002704)2.54856327
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54799670
138leukotriene biosynthetic process (GO:0019370)2.54216496
139positive regulation of lamellipodium assembly (GO:0010592)2.54015543
140positive regulation of type 2 immune response (GO:0002830)2.53733139
141response to muramyl dipeptide (GO:0032495)2.53428583
142regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.53082852
143signal peptide processing (GO:0006465)2.52263656
144necrotic cell death (GO:0070265)2.51993189
145response to interferon-alpha (GO:0035455)2.51736515
146regulation of phagocytosis (GO:0050764)2.50091737
147germ cell migration (GO:0008354)2.49316752
148negative regulation of B cell proliferation (GO:0030889)2.45217056
149pentose-phosphate shunt (GO:0006098)2.44030664
150negative regulation of granulocyte differentiation (GO:0030853)2.39762477
151regulation of interferon-beta biosynthetic process (GO:0045357)2.39636831
152secretory granule organization (GO:0033363)2.37282246
153histone-serine phosphorylation (GO:0035404)2.37220131
154positive regulation of macrophage differentiation (GO:0045651)2.34792253
155B cell receptor signaling pathway (GO:0050853)2.33834017
156IMP metabolic process (GO:0046040)2.32949108
157killing of cells of other organism (GO:0031640)2.31592019
158disruption of cells of other organism (GO:0044364)2.31592019
159leukocyte migration involved in inflammatory response (GO:0002523)2.29929458
160regulation of erythrocyte differentiation (GO:0045646)2.29695738
161regulation of DNA endoreduplication (GO:0032875)2.29036071
162toxin transport (GO:1901998)2.28631797
163regulation of RIG-I signaling pathway (GO:0039535)2.28592473
164response to interferon-beta (GO:0035456)2.28443020
165regulation of necrotic cell death (GO:0010939)2.28151743
166dendritic cell migration (GO:0036336)2.28121367
167endosome to pigment granule transport (GO:0043485)2.27923098
168endosome to melanosome transport (GO:0035646)2.27923098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.41965214
2GATA1_22025678_ChIP-Seq_K562_Human3.94497286
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.93186698
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.87683078
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.80992946
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64461752
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.32052688
8SCL_19346495_ChIP-Seq_HPC-7_Human3.29368215
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10017923
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.03126002
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.02898309
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98115780
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81986783
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72783381
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66514850
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64479610
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.50546300
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45757485
19SPI1_23547873_ChIP-Seq_NB4_Human2.34660612
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.34653780
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34257597
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25769781
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.23006255
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21371024
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18657582
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13063285
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08217825
28VDR_21846776_ChIP-Seq_THP-1_Human2.07320510
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00751350
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00020564
31VDR_24763502_ChIP-Seq_THP-1_Human1.92248566
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90863874
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86759632
34* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86442949
35* MYB_26560356_Chip-Seq_TH2_Human1.85655966
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.82762116
37ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80033338
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79345354
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76053558
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.75031132
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73470996
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71208038
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69514661
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.64792749
45MYB_26560356_Chip-Seq_TH1_Human1.63934335
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56544257
47RUNX_20019798_ChIP-Seq_JUKART_Human1.55425893
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.54779413
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51525238
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51080261
51* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50539997
52* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49499199
53PU_27001747_Chip-Seq_BMDM_Mouse1.49117962
54ELK1_19687146_ChIP-ChIP_HELA_Human1.45621758
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44527538
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44439412
57SPI1_23127762_ChIP-Seq_K562_Human1.44276391
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43891662
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42384176
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41769843
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.41210833
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39620576
63MYC_22102868_ChIP-Seq_BL_Human1.39397320
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.38719626
65MAF_26560356_Chip-Seq_TH1_Human1.36202114
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33715335
67* KDM2B_26808549_Chip-Seq_DND41_Human1.30279521
68UTX_26944678_Chip-Seq_JUKART_Human1.26779930
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26609471
70* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26362331
71* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25380146
72GATA1_19941826_ChIP-Seq_K562_Human1.24201699
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23164385
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.19655696
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.19023711
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18729373
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16165114
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14975131
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14057441
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13993915
81VDR_23849224_ChIP-Seq_CD4+_Human1.12551431
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.10448778
83GATA3_27048872_Chip-Seq_THYMUS_Human1.10168601
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08499811
85* MAF_26560356_Chip-Seq_TH2_Human1.08186683
86TCF7_22412390_ChIP-Seq_EML_Mouse1.07284664
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07004721
88* GATA3_26560356_Chip-Seq_TH2_Human1.06504424
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05872150
90TFEB_21752829_ChIP-Seq_HELA_Human1.04843700
91* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04667071
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03755330
93* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03307569
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02706403
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.02223047
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00556589
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98282584
98GATA2_19941826_ChIP-Seq_K562_Human0.98089006
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96813216
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96698974
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96623796
102AR_21909140_ChIP-Seq_LNCAP_Human0.96545382
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92957759
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.90182089
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89821300
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88259886
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88196860
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86649444
109* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86565458
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86274993
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86274993
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.84798355
113GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84120865
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84003726
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83635974
116FOXP3_21729870_ChIP-Seq_TREG_Human0.83219615
117* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81764149
118VDR_24787735_ChIP-Seq_THP-1_Human0.81682090
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81650867
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80528700
121CLOCK_20551151_ChIP-Seq_293T_Human0.79660661
122CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79637171
123* BRD4_25478319_ChIP-Seq_HGPS_Human0.79331025
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79302866
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78849147
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78836397
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75295590
128TP53_16413492_ChIP-PET_HCT116_Human0.73844089
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72516018
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71729402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.36472571
2MP0006054_spinal_hemorrhage2.81643436
3MP0001835_abnormal_antigen_presentation2.74322275
4MP0002396_abnormal_hematopoietic_system2.66379306
5MP0003436_decreased_susceptibility_to2.49862990
6MP0009785_altered_susceptibility_to2.34667618
7MP0002419_abnormal_innate_immunity2.33000146
8MP0001958_emphysema2.27128860
9MP0003724_increased_susceptibility_to2.26100658
10MP0005464_abnormal_platelet_physiology2.24317402
11MP0005503_abnormal_tendon_morphology2.24172726
12MP0000465_gastrointestinal_hemorrhage2.23441392
13MP0005275_abnormal_skin_tensile2.22227578
14MP0005397_hematopoietic_system_phenotyp2.13604927
15MP0001545_abnormal_hematopoietic_system2.13604927
16MP0002166_altered_tumor_susceptibility2.12800613
17MP0003303_peritoneal_inflammation2.11070440
18MP0004808_abnormal_hematopoietic_stem2.00978343
19MP0002148_abnormal_hypersensitivity_rea1.98118327
20MP0002877_abnormal_melanocyte_morpholog1.97325031
21MP0005025_abnormal_response_to1.95945082
22MP0004510_myositis1.93207353
23MP0001533_abnormal_skeleton_physiology1.82757428
24MP0004782_abnormal_surfactant_physiolog1.81129364
25MP0005000_abnormal_immune_tolerance1.79175448
26MP0002452_abnormal_antigen_presenting1.72066961
27MP0000685_abnormal_immune_system1.71794857
28MP0002420_abnormal_adaptive_immunity1.68969482
29MP0000343_altered_response_to1.68417737
30MP0001819_abnormal_immune_cell1.67135224
31MP0003300_gastrointestinal_ulcer1.65944234
32MP0003183_abnormal_peptide_metabolism1.63456932
33MP0003566_abnormal_cell_adhesion1.60512427
34MP0005671_abnormal_response_to1.59573572
35MP0008004_abnormal_stomach_pH1.58922949
36MP0002006_tumorigenesis1.58230166
37MP0001800_abnormal_humoral_immune1.55725379
38MP0000604_amyloidosis1.54909851
39MP0002723_abnormal_immune_serum1.54640830
40MP0005174_abnormal_tail_pigmentation1.53674950
41MP0008260_abnormal_autophagy1.52491068
42MP0005451_abnormal_body_composition1.51535874
43MP0002398_abnormal_bone_marrow1.49221739
44MP0004883_abnormal_blood_vessel1.48361000
45MP0002933_joint_inflammation1.48315703
46MP0002405_respiratory_system_inflammati1.48017933
47MP0001873_stomach_inflammation1.47979456
48MP0010307_abnormal_tumor_latency1.46141032
49MP0003279_aneurysm1.44848959
50MP0009840_abnormal_foam_cell1.42531819
51MP0006082_CNS_inflammation1.41961274
52MP0005387_immune_system_phenotype1.41500581
53MP0001790_abnormal_immune_system1.41500581
54MP0000716_abnormal_immune_system1.36909533
55MP0001845_abnormal_inflammatory_respons1.34762353
56MP0001879_abnormal_lymphatic_vessel1.34078241
57MP0003693_abnormal_embryo_hatching1.33747370
58MP0003172_abnormal_lysosome_physiology1.33593616
59MP0009278_abnormal_bone_marrow1.29816029
60MP0000858_altered_metastatic_potential1.29724811
61MP0010155_abnormal_intestine_physiology1.27946319
62MP0000569_abnormal_digit_pigmentation1.27938483
63MP0002429_abnormal_blood_cell1.24985258
64MP0002998_abnormal_bone_remodeling1.24701964
65MP0010352_gastrointestinal_tract_polyps1.24454391
66MP0002060_abnormal_skin_morphology1.23372534
67MP0001853_heart_inflammation1.23315808
68MP0005166_decreased_susceptibility_to1.22749748
69MP0000689_abnormal_spleen_morphology1.22405496
70MP0005058_abnormal_lysosome_morphology1.21045005
71MP0000490_abnormal_crypts_of1.19926340
72MP0003448_altered_tumor_morphology1.19795503
73MP0005310_abnormal_salivary_gland1.19242246
74MP0002722_abnormal_immune_system1.18714570
75MP0003763_abnormal_thymus_physiology1.16330997
76MP0001851_eye_inflammation1.15630031
77MP0005390_skeleton_phenotype1.15331336
78MP0003656_abnormal_erythrocyte_physiolo1.15006781
79MP0003690_abnormal_glial_cell1.14664498
80MP0008469_abnormal_protein_level1.07979622
81MP0005023_abnormal_wound_healing1.05578624
82MP0003191_abnormal_cellular_cholesterol1.04854691
83MP0003221_abnormal_cardiomyocyte_apopto1.02282063
84MP0003795_abnormal_bone_structure1.01395677
85MP0001542_abnormal_bone_strength1.00020085
86MP0002332_abnormal_exercise_endurance0.98406214
87MP0010368_abnormal_lymphatic_system0.97618568
88MP0003950_abnormal_plasma_membrane0.95917777
89MP0008007_abnormal_cellular_replicative0.94017889
90MP0004147_increased_porphyrin_level0.93642280
91MP0005164_abnormal_response_to0.92882922
92MP0004947_skin_inflammation0.92302612
93MP0009333_abnormal_splenocyte_physiolog0.91115263
94MP0003828_pulmonary_edema0.90736854
95MP0002095_abnormal_skin_pigmentation0.89878585
96MP0003705_abnormal_hypodermis_morpholog0.89217029
97MP0009764_decreased_sensitivity_to0.88143452
98MP0003453_abnormal_keratinocyte_physiol0.86717071
99MP0000249_abnormal_blood_vessel0.86270648
100MP0000015_abnormal_ear_pigmentation0.86003875
101MP0002019_abnormal_tumor_incidence0.85504847
102MP0003943_abnormal_hepatobiliary_system0.85344828
103MP0010094_abnormal_chromosome_stability0.85327221
104MP0009384_cardiac_valve_regurgitation0.84906032
105MP0003091_abnormal_cell_migration0.81807871
106MP0000703_abnormal_thymus_morphology0.80002284
107MP0003866_abnormal_defecation0.79859458
108MP0003075_altered_response_to0.76872194
109MP0005076_abnormal_cell_differentiation0.75416563
110MP0002009_preneoplasia0.75310039
111MP0000767_abnormal_smooth_muscle0.75043126
112MP0005167_abnormal_blood-brain_barrier0.72845185
113MP0005075_abnormal_melanosome_morpholog0.72275102
114MP0001243_abnormal_dermal_layer0.72117913
115MP0009763_increased_sensitivity_to0.71907118
116MP0002133_abnormal_respiratory_system0.70713557
117MP0005388_respiratory_system_phenotype0.70713557
118MP0000920_abnormal_myelination0.70055627
119MP0003329_amyloid_beta_deposits0.69689488
120MP0009765_abnormal_xenobiotic_induced0.68937788
121MP0002132_abnormal_respiratory_system0.68785099
122MP0001175_abnormal_lung_morphology0.67878568
123MP0003045_fibrosis0.64331121
124MP0001663_abnormal_digestive_system0.63572595
125MP0008961_abnormal_basal_metabolism0.62957778

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.48683035
2Abnormality of liposaccharide metabolism (HP:0010968)4.48683035
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.48683035
4Recurrent abscess formation (HP:0002722)4.12824683
5Thrombocytosis (HP:0001894)4.11621714
6Stomatitis (HP:0010280)3.87145362
7Optic neuritis (HP:0100653)3.72823534
8Retrobulbar optic neuritis (HP:0100654)3.72823534
9Eczematoid dermatitis (HP:0000976)3.67470901
10Recurrent bacterial skin infections (HP:0005406)3.47895361
11Dysostosis multiplex (HP:0000943)3.27393052
12Spontaneous hematomas (HP:0007420)3.20134145
13Autoimmune thrombocytopenia (HP:0001973)3.09290075
14Prolonged bleeding time (HP:0003010)3.08683612
15Cervical subluxation (HP:0003308)3.07571905
16Hematochezia (HP:0002573)3.06138187
17Protrusio acetabuli (HP:0003179)2.99450781
18Petechiae (HP:0000967)2.97852202
19Recurrent gram-negative bacterial infections (HP:0005420)2.88911030
20Beaking of vertebral bodies (HP:0004568)2.88682543
21Myositis (HP:0100614)2.88354558
22Interstitial pulmonary disease (HP:0006530)2.83123398
23IgM deficiency (HP:0002850)2.79031352
24Elevated erythrocyte sedimentation rate (HP:0003565)2.78825712
25Keratoconjunctivitis sicca (HP:0001097)2.77746574
26Abnormal number of erythroid precursors (HP:0012131)2.77117745
27Abnormal platelet function (HP:0011869)2.74856208
28Impaired platelet aggregation (HP:0003540)2.74856208
29Amyloidosis (HP:0011034)2.74714843
30Gastrointestinal infarctions (HP:0005244)2.71505803
31Disinhibition (HP:0000734)2.68761209
32Chronic obstructive pulmonary disease (HP:0006510)2.68105352
33Obstructive lung disease (HP:0006536)2.68105352
34Loss of speech (HP:0002371)2.66481447
35Ankle contracture (HP:0006466)2.65870884
36Chronic otitis media (HP:0000389)2.64570825
37Recurrent fungal infections (HP:0002841)2.63607522
38Aplastic anemia (HP:0001915)2.63576225
39Premature rupture of membranes (HP:0001788)2.60422721
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60196747
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60196747
42Abnormality of polysaccharide metabolism (HP:0011012)2.60196747
43Osteolytic defects of the hand bones (HP:0009699)2.59204890
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.59204890
45Abnormality of cells of the erythroid lineage (HP:0012130)2.56998959
46Epistaxis (HP:0000421)2.54847805
47Abnormality of the lumbar spine (HP:0100712)2.52924617
48Recurrent viral infections (HP:0004429)2.52624454
49Urinary glycosaminoglycan excretion (HP:0003541)2.52517760
50Keratoconjunctivitis (HP:0001096)2.46794765
51Periodontitis (HP:0000704)2.46601698
52Abnormal platelet volume (HP:0011876)2.43302271
53Cellulitis (HP:0100658)2.43267005
54Encephalitis (HP:0002383)2.42179774
55Chest pain (HP:0100749)2.39939280
56Myocardial infarction (HP:0001658)2.38289534
57Abnormality of T cell physiology (HP:0011840)2.38279560
58Spondylolisthesis (HP:0003302)2.37767385
59Reduced antithrombin III activity (HP:0001976)2.32084855
60Delayed closure of the anterior fontanelle (HP:0001476)2.31831313
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.31747922
62Abnormality of the prostate (HP:0008775)2.30562788
63Recurrent skin infections (HP:0001581)2.30476364
64Gingivitis (HP:0000230)2.29160473
65Increased IgE level (HP:0003212)2.28586678
66Asymmetric septal hypertrophy (HP:0001670)2.27847745
67Aortic dissection (HP:0002647)2.26495833
68Papilledema (HP:0001085)2.26235517
69Mediastinal lymphadenopathy (HP:0100721)2.25531662
70Recurrent bronchitis (HP:0002837)2.25388224
71Absent frontal sinuses (HP:0002688)2.21761587
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.21484330
73Autoimmune hemolytic anemia (HP:0001890)2.20985499
74Meningitis (HP:0001287)2.18119823
75Episodic fever (HP:0001954)2.15354257
76Pulmonary embolism (HP:0002204)2.14684872
77Aortic aneurysm (HP:0004942)2.14354233
78Vacuolated lymphocytes (HP:0001922)2.14014182
79Osteomyelitis (HP:0002754)2.12671926
80Peritonitis (HP:0002586)2.12667755
81Epiphyseal dysplasia (HP:0002656)2.11765386
82Gingival bleeding (HP:0000225)2.11435455
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.11270504
84Abnormality of macrophages (HP:0004311)2.10130797
85Albinism (HP:0001022)2.09225257
86Systemic lupus erythematosus (HP:0002725)2.09033015
87Leukocytosis (HP:0001974)2.07413160
88Thoracolumbar scoliosis (HP:0002944)2.06928101
89Arterial thrombosis (HP:0004420)2.05786165
90Orchitis (HP:0100796)2.05435227
91Abnormal foot bone ossification (HP:0010675)2.04174444
92Pulmonary infiltrates (HP:0002113)2.00358938
93Vertebral compression fractures (HP:0002953)2.00241984
94Increased mean platelet volume (HP:0011877)2.00147086
95Vasculitis (HP:0002633)1.99232050
96Neurofibrillary tangles (HP:0002185)1.97650581
97Chronic mucocutaneous candidiasis (HP:0002728)1.97416684
98Recurrent cutaneous fungal infections (HP:0011370)1.97416684
99Dilatation of the ascending aorta (HP:0005111)1.97111136
100Abnormality of T cells (HP:0002843)1.96901251
101Hemoptysis (HP:0002105)1.95932993
102Increased cerebral lipofuscin (HP:0011813)1.95810897
103Pustule (HP:0200039)1.95646375
104Slender build (HP:0001533)1.95540537
105Purpura (HP:0000979)1.93539747
106Abnormality of the thoracic spine (HP:0100711)1.92780312
107Long clavicles (HP:0000890)1.92716102
108Gangrene (HP:0100758)1.92577307
109Increased IgM level (HP:0003496)1.92419251
110Hypergammaglobulinemia (HP:0010702)1.92113968
111Granulocytopenia (HP:0001913)1.91982229
112Thoracic kyphosis (HP:0002942)1.91924846
113Eosinophilia (HP:0001880)1.91610001
114Recurrent lower respiratory tract infections (HP:0002783)1.88711896
115Recurrent pneumonia (HP:0006532)1.88614288
116Glomerulopathy (HP:0100820)1.87596473
117Inflammation of the large intestine (HP:0002037)1.87389510
118Fatigue (HP:0012378)1.87244614
119Spinal cord lesions (HP:0100561)1.86952074
120Syringomyelia (HP:0003396)1.86952074
121Abnormality of the peritoneum (HP:0002585)1.86930757
122Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86857381
123Slender long bone (HP:0003100)1.85568209
124Bruising susceptibility (HP:0000978)1.85113603
125Soft skin (HP:0000977)1.84697909
126Abnormality of T cell number (HP:0011839)1.83556231
127Abnormality of the frontal sinuses (HP:0002687)1.83494557
128Diminished motivation (HP:0000745)1.83222575
129Mutism (HP:0002300)1.83123960
130Acute myeloid leukemia (HP:0004808)1.82731624
131T lymphocytopenia (HP:0005403)1.82669876
132Apathy (HP:0000741)1.82358573
133Broad metatarsal (HP:0001783)1.81405532
134Neuronal loss in central nervous system (HP:0002529)1.81139518
135Metaphyseal dysplasia (HP:0100255)1.81104510
136Gastrointestinal inflammation (HP:0004386)1.80411261
137Cupped ribs (HP:0000887)1.78605843
138Premature loss of primary teeth (HP:0006323)1.78526817
139Polyneuropathy (HP:0001271)1.78469025
140Urticaria (HP:0001025)1.77888282
141Hypoplasia of the thymus (HP:0000778)1.77063422
142Abnormality of the fingertips (HP:0001211)1.76673898
143Thickened calvaria (HP:0002684)1.74694625
144Patchy hypopigmentation of hair (HP:0011365)1.73900860
145Colitis (HP:0002583)1.73686328
146Increased CSF protein (HP:0002922)1.73471042
147Hepatosplenomegaly (HP:0001433)1.73450483
148Conjunctival telangiectasia (HP:0000524)1.73376806
149Mucopolysacchariduria (HP:0008155)1.73086913
150Increased serum ferritin (HP:0003281)1.73082245
151Slow saccadic eye movements (HP:0000514)1.72691584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K33.37198714
2IRAK43.28219137
3PRPF4B3.16607631
4MAP3K32.78470343
5TEC2.71991012
6KIT2.67691198
7MAP4K12.47336308
8TRPM72.46901435
9TAOK32.45506602
10BTK2.01662961
11TTN1.99644561
12FRK1.97309819
13TGFBR21.87093533
14MAP3K141.86740179
15RPS6KA41.81181167
16BRSK21.77419590
17BMPR21.70121207
18GRK71.69978688
19TYK21.60925890
20FGR1.56350595
21FLT31.55661304
22EEF2K1.52270760
23PIM21.50554338
24ZAP701.49848351
25ERBB31.49800867
26ERN11.49458182
27PKN21.48102149
28TGFBR11.48012184
29TIE11.47433587
30FGFR31.44818336
31TAOK11.43640351
32SIK31.43317177
33MOS1.40766595
34JAK31.38386129
35JAK11.34926631
36NEK91.33865940
37ZAK1.33771705
38TXK1.30792531
39VRK11.30195434
40LRRK21.30001112
41IRAK31.29015945
42CSF1R1.27863818
43TBK11.20567968
44CSK1.19224897
45STK101.18951669
46SCYL21.16797708
47PIK3CG1.15074176
48MAP3K11.14891425
49ITK1.14265759
50KSR21.11481478
51WEE11.10734312
52MAP3K51.10061765
53IRAK11.06519834
54BLK1.04521507
55IKBKB1.04152409
56FES1.03447586
57PIM11.03019075
58SYK1.02441314
59STK241.01239184
60IRAK21.00289842
61CDC42BPA0.99274517
62NEK20.96713895
63STK40.96532288
64NME20.96104212
65IKBKE0.95726492
66PAK40.95427495
67MARK30.93214524
68MAPK70.92165336
69LYN0.91561445
70STK160.89443174
71EIF2AK30.88985892
72MAP3K60.80517518
73CDK80.80357684
74KDR0.79953788
75HCK0.79451147
76MARK20.78479512
77CAMKK20.78435349
78MAP3K110.76732365
79TRIB30.73810901
80MATK0.73694641
81RIPK10.73664313
82PTK60.72105497
83EIF2AK20.71283533
84RPS6KB20.70899198
85YES10.69405463
86PDGFRA0.68857427
87JAK20.68844157
88MYLK0.68443430
89KSR10.67554451
90MAPK120.67227223
91PRKD20.66001825
92LCK0.65670548
93ACVR1B0.65529243
94TESK10.64600683
95TNK20.63413528
96CDC70.61500317
97HIPK20.61058699
98ATR0.60997342
99CDK60.60114465
100PRKG20.59754155
101MAP3K20.59547939
102PDK10.59452654
103SGK30.58944090
104CDK120.58825429
105MKNK10.58229314
106CHUK0.57273374
107SIK20.56913929
108MAPKAPK50.55709062
109MAPK40.50801443
110PDPK10.50458056
111CDK70.50186506
112CAMK1D0.49582853
113PASK0.49230436
114FYN0.44743007
115MAPKAPK30.44351933
116EPHB10.43954184
117RET0.43715521
118ABL10.43495614
119MAPKAPK20.43257139
120GRK10.43048749
121BUB10.43014298
122MAP3K120.42646532
123PDGFRB0.41168625
124TAOK20.41130920
125RAF10.40748547
126PIK3CA0.40588082
127DDR20.38726433
128SGK20.38692367
129MAP3K130.38425189
130DYRK1B0.38413100
131MAP2K60.38377545
132EPHA30.38304197
133AURKB0.38071064
134RIPK40.37654414
135WNK10.37451800
136GRK60.37345872
137RPS6KA60.37216352
138RPS6KC10.36250764
139RPS6KL10.36250764
140EGFR0.36221136
141NTRK20.35742578
142TESK20.34510945
143STK380.32339090
144BRD40.32221547
145PTK2B0.32185164
146MAP3K70.31027484
147RPS6KA20.30851184

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.76594438
2DNA replication_Homo sapiens_hsa030302.52630534
3* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.49366117
4Other glycan degradation_Homo sapiens_hsa005111.94623222
5Malaria_Homo sapiens_hsa051441.90125694
6Osteoclast differentiation_Homo sapiens_hsa043801.85418257
7Antigen processing and presentation_Homo sapiens_hsa046121.84377660
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.82591285
9Rheumatoid arthritis_Homo sapiens_hsa053231.75775571
10Hematopoietic cell lineage_Homo sapiens_hsa046401.73836947
11Legionellosis_Homo sapiens_hsa051341.71923487
12Pertussis_Homo sapiens_hsa051331.67508103
13N-Glycan biosynthesis_Homo sapiens_hsa005101.63330882
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.59372217
15ECM-receptor interaction_Homo sapiens_hsa045121.54327700
16Platelet activation_Homo sapiens_hsa046111.54034865
17Asthma_Homo sapiens_hsa053101.51118804
18T cell receptor signaling pathway_Homo sapiens_hsa046601.50607035
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49853940
20Measles_Homo sapiens_hsa051621.46253775
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45982546
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45685467
23Staphylococcus aureus infection_Homo sapiens_hsa051501.45201149
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.43019941
25Toxoplasmosis_Homo sapiens_hsa051451.41760964
26Autoimmune thyroid disease_Homo sapiens_hsa053201.41487201
27Protein export_Homo sapiens_hsa030601.41055646
28Mismatch repair_Homo sapiens_hsa034301.40922945
29Lysosome_Homo sapiens_hsa041421.38504911
30Apoptosis_Homo sapiens_hsa042101.38133314
31Phagosome_Homo sapiens_hsa041451.37898337
32Herpes simplex infection_Homo sapiens_hsa051681.37589745
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37509245
34B cell receptor signaling pathway_Homo sapiens_hsa046621.36566050
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.35856080
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35270260
37Tuberculosis_Homo sapiens_hsa051521.34212017
38Homologous recombination_Homo sapiens_hsa034401.32918500
39Primary immunodeficiency_Homo sapiens_hsa053401.30459760
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29264053
41Renin-angiotensin system_Homo sapiens_hsa046141.28417323
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27732649
43Base excision repair_Homo sapiens_hsa034101.27274898
44Type I diabetes mellitus_Homo sapiens_hsa049401.25152161
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23398671
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23103920
47Small cell lung cancer_Homo sapiens_hsa052221.22936840
48Ribosome_Homo sapiens_hsa030101.19932890
49Shigellosis_Homo sapiens_hsa051311.18435372
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.15601839
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14468786
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13685592
53Focal adhesion_Homo sapiens_hsa045101.12705504
54Hepatitis B_Homo sapiens_hsa051611.12161563
55TNF signaling pathway_Homo sapiens_hsa046681.11939940
56Renal cell carcinoma_Homo sapiens_hsa052111.06624323
57African trypanosomiasis_Homo sapiens_hsa051431.06394636
58Cell cycle_Homo sapiens_hsa041101.05544575
59Influenza A_Homo sapiens_hsa051641.02473895
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01815810
61Non-homologous end-joining_Homo sapiens_hsa034500.99533732
62p53 signaling pathway_Homo sapiens_hsa041150.99341508
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97905548
64Chronic myeloid leukemia_Homo sapiens_hsa052200.97338651
65Caffeine metabolism_Homo sapiens_hsa002320.95709085
66Non-small cell lung cancer_Homo sapiens_hsa052230.94052970
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93591064
68VEGF signaling pathway_Homo sapiens_hsa043700.93449837
69Dorso-ventral axis formation_Homo sapiens_hsa043200.92108885
70One carbon pool by folate_Homo sapiens_hsa006700.90576543
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90384906
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89933155
73Salmonella infection_Homo sapiens_hsa051320.89085105
74Pancreatic cancer_Homo sapiens_hsa052120.88268809
75Prolactin signaling pathway_Homo sapiens_hsa049170.88056757
76Systemic lupus erythematosus_Homo sapiens_hsa053220.87081963
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86699556
78Chemokine signaling pathway_Homo sapiens_hsa040620.86002453
79Amoebiasis_Homo sapiens_hsa051460.84832264
80Acute myeloid leukemia_Homo sapiens_hsa052210.84295660
81Starch and sucrose metabolism_Homo sapiens_hsa005000.84001195
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82720757
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80701309
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80635261
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.80307783
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79868899
87Viral carcinogenesis_Homo sapiens_hsa052030.77221775
88Fanconi anemia pathway_Homo sapiens_hsa034600.75666582
89GnRH signaling pathway_Homo sapiens_hsa049120.73692197
90Viral myocarditis_Homo sapiens_hsa054160.72306043
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.70078871
92FoxO signaling pathway_Homo sapiens_hsa040680.69707511
93HTLV-I infection_Homo sapiens_hsa051660.68775875
94Nucleotide excision repair_Homo sapiens_hsa034200.67808626
95Bladder cancer_Homo sapiens_hsa052190.66818085
96Graft-versus-host disease_Homo sapiens_hsa053320.66187751
97Pentose phosphate pathway_Homo sapiens_hsa000300.65238851
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64418124
99Galactose metabolism_Homo sapiens_hsa000520.63496758
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62851352
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.62320203
102Prion diseases_Homo sapiens_hsa050200.62302013
103Proteoglycans in cancer_Homo sapiens_hsa052050.61281294
104Endocytosis_Homo sapiens_hsa041440.59918269
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59632025
106Allograft rejection_Homo sapiens_hsa053300.58551260
107MAPK signaling pathway_Homo sapiens_hsa040100.57950159
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57401324
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55778949
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55687798
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55095718
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54896501
113Endometrial cancer_Homo sapiens_hsa052130.54477023
114Selenocompound metabolism_Homo sapiens_hsa004500.54342755
115ABC transporters_Homo sapiens_hsa020100.53373165
116mTOR signaling pathway_Homo sapiens_hsa041500.52917716
117Epstein-Barr virus infection_Homo sapiens_hsa051690.52484393
118Protein digestion and absorption_Homo sapiens_hsa049740.52425164
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52406157
120Estrogen signaling pathway_Homo sapiens_hsa049150.51419103
121Colorectal cancer_Homo sapiens_hsa052100.51343371
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.51128375
123Sphingolipid metabolism_Homo sapiens_hsa006000.50758307
124MicroRNAs in cancer_Homo sapiens_hsa052060.50147253
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49901735
126HIF-1 signaling pathway_Homo sapiens_hsa040660.49754015
127Hepatitis C_Homo sapiens_hsa051600.48876116
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47268177
129ErbB signaling pathway_Homo sapiens_hsa040120.46783960
130Prostate cancer_Homo sapiens_hsa052150.46548504
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46249095
132RNA degradation_Homo sapiens_hsa030180.45659237
133Type II diabetes mellitus_Homo sapiens_hsa049300.44926110
134Notch signaling pathway_Homo sapiens_hsa043300.44127369
135Choline metabolism in cancer_Homo sapiens_hsa052310.43873078
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43630524
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40721259

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