CSF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of metanephros development (GO:0072217)9.08139947
2negative regulation of interleukin-17 production (GO:0032700)8.17261970
3regulation of isotype switching to IgG isotypes (GO:0048302)8.12561404
4* positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.92833791
5positive regulation of T cell chemotaxis (GO:0010820)7.82989361
6regulation of T cell chemotaxis (GO:0010819)7.82989361
7positive regulation of immunoglobulin mediated immune response (GO:0002891)7.69997791
8positive regulation of B cell mediated immunity (GO:0002714)7.69997791
9regulation of MHC class II biosynthetic process (GO:0045346)7.46736017
10regulation of chemokine biosynthetic process (GO:0045073)6.98902255
11* regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.47239335
12regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)6.44568870
13positive regulation of T cell cytokine production (GO:0002726)6.41860070
14positive regulation of isotype switching (GO:0045830)6.35261651
15regulation of immunoglobulin secretion (GO:0051023)6.34818051
16regulation of lymphocyte chemotaxis (GO:1901623)6.30280005
17T cell differentiation involved in immune response (GO:0002292)6.15235059
18alpha-beta T cell differentiation involved in immune response (GO:0002293)6.15235059
19alpha-beta T cell activation involved in immune response (GO:0002287)6.15235059
20negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.12234769
21defense response to protozoan (GO:0042832)6.11428170
22regulation of regulatory T cell differentiation (GO:0045589)6.06692089
23positive regulation of steroid biosynthetic process (GO:0010893)6.04184516
24negative regulation of neurological system process (GO:0031645)5.95982015
25regulation of interleukin-12 biosynthetic process (GO:0045075)5.88957060
26negative regulation of T cell mediated immunity (GO:0002710)5.83007968
27regulation of immunoglobulin mediated immune response (GO:0002889)5.82882332
28positive regulation of muscle cell apoptotic process (GO:0010661)5.80580333
29regulation of chronic inflammatory response (GO:0002676)5.75364667
30regulation of B cell mediated immunity (GO:0002712)5.63302100
31regulation of interleukin-6 biosynthetic process (GO:0045408)5.61224035
32positive regulation of humoral immune response (GO:0002922)5.60803917
33positive regulation of T cell mediated cytotoxicity (GO:0001916)5.60712461
34regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.48890792
35positive regulation of immune response to tumor cell (GO:0002839)5.45161429
36regulation of immune response to tumor cell (GO:0002837)5.45161429
37regulation of response to tumor cell (GO:0002834)5.45161429
38positive regulation of response to tumor cell (GO:0002836)5.45161429
39regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.38436446
40positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.38436446
41positive regulation of DNA recombination (GO:0045911)5.38302681
42leukocyte apoptotic process (GO:0071887)5.34353424
43positive regulation of immunoglobulin production (GO:0002639)5.33580007
44activated T cell proliferation (GO:0050798)5.30173526
45response to protozoan (GO:0001562)5.29705564
46regulation of smooth muscle cell apoptotic process (GO:0034391)5.24975586
47regulation of membrane protein ectodomain proteolysis (GO:0051043)5.20701935
48positive regulation of interleukin-17 production (GO:0032740)5.18780256
49positive regulation of T-helper 1 type immune response (GO:0002827)5.15714538
50positive regulation of interleukin-1 beta secretion (GO:0050718)5.12375864
51negative regulation of kidney development (GO:0090185)5.10923978
52positive regulation of cell killing (GO:0031343)5.01704511
53positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.00105249
54regulation of vitamin D biosynthetic process (GO:0060556)4.99577458
55positive regulation of interleukin-1 secretion (GO:0050716)4.86665167
56regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.84819973
57regulation of T cell mediated cytotoxicity (GO:0001914)4.84364235
58regulation of interleukin-1 beta secretion (GO:0050706)4.78259320
59positive regulation of lymphocyte mediated immunity (GO:0002708)4.76833969
60positive regulation of monooxygenase activity (GO:0032770)4.75377762
61negative regulation of cytokine production involved in immune response (GO:0002719)4.73990838
62positive regulation of interleukin-12 production (GO:0032735)4.71581192
63positive regulation of type 2 immune response (GO:0002830)4.67040331
64regulation of immunoglobulin production (GO:0002637)4.67038580
65regulation of leukocyte mediated cytotoxicity (GO:0001910)4.63044897
66regulation of cell killing (GO:0031341)4.62153482
67positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.60825094
68positive regulation of activated T cell proliferation (GO:0042104)4.57547899
69regulation of isotype switching (GO:0045191)4.54311382
70regulation of vitamin metabolic process (GO:0030656)4.44762108
71positive regulation of alcohol biosynthetic process (GO:1902932)4.35701090
72regulation of interleukin-1 secretion (GO:0050704)4.32412113
73positive regulation of alpha-beta T cell proliferation (GO:0046641)4.29863644
74regulation of T cell cytokine production (GO:0002724)4.29525174
75regulation of cytokine production involved in inflammatory response (GO:1900015)4.28903678
76alpha-beta T cell differentiation (GO:0046632)4.25938118
77positive regulation of lymphocyte migration (GO:2000403)4.20512635
78protein import into nucleus, translocation (GO:0000060)4.19001686
79interferon-gamma production (GO:0032609)4.18750786
80regulation of response to interferon-gamma (GO:0060330)4.16543281
81positive regulation of natural killer cell mediated immunity (GO:0002717)4.14050714
82positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.14050714
83positive regulation of leukocyte mediated immunity (GO:0002705)4.11813249
84regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.11761435
85negative regulation of production of molecular mediator of immune response (GO:0002701)4.07190610
86cellular response to interleukin-15 (GO:0071350)4.05009915
87regulation of natural killer cell mediated immunity (GO:0002715)4.04850628
88regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.04850628
89regulation of T-helper 1 type immune response (GO:0002825)4.03321850
90regulation of interleukin-17 production (GO:0032660)4.02640978
91negative regulation of B cell apoptotic process (GO:0002903)4.01490707
92positive regulation of chemokine biosynthetic process (GO:0045080)4.00257888
93regulation of alpha-beta T cell proliferation (GO:0046640)3.98029512
94lymphocyte chemotaxis (GO:0048247)3.94414780
95positive regulation of T cell migration (GO:2000406)3.90954458
96negative regulation of lymphocyte mediated immunity (GO:0002707)3.90159260
97regulation of fever generation (GO:0031620)3.89404823
98regulation of lymphocyte mediated immunity (GO:0002706)3.86168813
99positive regulation of gamma-delta T cell activation (GO:0046645)3.85639441
100negative regulation of growth of symbiont in host (GO:0044130)3.85222210
101negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.85222210
102modulation of growth of symbiont involved in interaction with host (GO:0044144)3.85222210
103regulation of growth of symbiont in host (GO:0044126)3.85222210
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.84962423
105positive regulation of heat generation (GO:0031652)3.83790661
106regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.82623140
107positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.79583271
108* positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.76789202
109positive regulation of interleukin-1 beta production (GO:0032731)3.76386965
110positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.74803606
111tyrosine phosphorylation of STAT protein (GO:0007260)3.74505770
112regulation of gamma-delta T cell differentiation (GO:0045586)3.73941176
113negative regulation of interleukin-2 production (GO:0032703)3.72407801
114regulation of metanephros development (GO:0072215)3.69553586
115regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.69220624
116positive regulation of transforming growth factor beta production (GO:0071636)3.64355170
117alpha-beta T cell activation (GO:0046631)3.60838779
118regulation of interleukin-12 production (GO:0032655)3.60186729
119positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.57563591
120positive regulation of adaptive immune response (GO:0002821)3.55888994
121negative regulation of alpha-beta T cell activation (GO:0046636)3.53954453
122regulation of gamma-delta T cell activation (GO:0046643)3.50038044
123positive regulation of steroid metabolic process (GO:0045940)3.45047402
124positive regulation of phosphatase activity (GO:0010922)3.41810081
125positive regulation of T cell mediated immunity (GO:0002711)3.39573474
126regulation of activated T cell proliferation (GO:0046006)3.37970129
127regulation of lymphocyte migration (GO:2000401)3.36437255
128response to interleukin-15 (GO:0070672)3.34852342
129regulation of T cell migration (GO:2000404)3.34322439
130positive regulation of interleukin-1 production (GO:0032732)3.34010162
131positive regulation of production of molecular mediator of immune response (GO:0002702)3.33567227
132positive regulation of myeloid leukocyte differentiation (GO:0002763)3.33295079
133positive regulation of osteoclast differentiation (GO:0045672)3.31090532
134tolerance induction (GO:0002507)3.29419485
135cellular response to nicotine (GO:0071316)3.26710386
136* regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.26648327
137positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.26156471
138T cell proliferation (GO:0042098)3.25636462
139positive regulation of neutrophil migration (GO:1902624)3.24728151
140positive regulation of neutrophil chemotaxis (GO:0090023)3.24728151
141negative regulation of smooth muscle cell proliferation (GO:0048662)3.13744622
142T cell activation involved in immune response (GO:0002286)3.06164399
143regulation of the force of heart contraction (GO:0002026)3.06056710
144positive regulation of nitric oxide biosynthetic process (GO:0045429)3.00657991
145* positive regulation of JAK-STAT cascade (GO:0046427)2.98296487
146positive regulation of T cell proliferation (GO:0042102)2.89297218
147positive regulation of natural killer cell differentiation (GO:0032825)2.83246820
148positive regulation of interleukin-10 production (GO:0032733)2.78226512
149negative regulation of macrophage differentiation (GO:0045650)2.76347120
150regulation of osteoclast differentiation (GO:0045670)2.73340804
151regulation of cellular amino acid metabolic process (GO:0006521)2.65729767
152regulation of interleukin-1 beta production (GO:0032651)2.65588887
153regulation of nitric oxide biosynthetic process (GO:0045428)2.60566281
154positive regulation of oxidoreductase activity (GO:0051353)2.59911061
155regulation of DNA recombination (GO:0000018)2.53875396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.79492862
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.36268756
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.19475026
4EGR1_19374776_ChIP-ChIP_THP-1_Human5.66479193
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.30112984
6STAT4_19710469_ChIP-ChIP_TH1__Mouse4.07579421
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83876988
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.75977142
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.53363949
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.46806345
11RUNX_20019798_ChIP-Seq_JUKART_Human2.91018252
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72037791
13* MYB_26560356_Chip-Seq_TH2_Human2.66103224
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62623265
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.61714022
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54058352
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.48427614
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.41575917
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36026964
20MYC_22102868_ChIP-Seq_BL_Human2.34452478
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33762612
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29865276
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.24747807
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24416685
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23854886
26MYB_26560356_Chip-Seq_TH1_Human2.23203250
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.15038066
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12704154
29* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12394241
30MAF_26560356_Chip-Seq_TH1_Human2.12228436
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06470890
32GATA1_26923725_Chip-Seq_HPCs_Mouse2.02081366
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.97025934
34VDR_23849224_ChIP-Seq_CD4+_Human1.95373677
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95316502
36GATA3_27048872_Chip-Seq_THYMUS_Human1.95273666
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92719967
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.92305135
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.87149729
40E2F7_22180533_ChIP-Seq_HELA_Human1.84386954
41* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81884324
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76024517
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75668211
44DCP1A_22483619_ChIP-Seq_HELA_Human1.72011438
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66337163
46CLOCK_20551151_ChIP-Seq_293T_Human1.62387881
47LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60360799
48UTX_26944678_Chip-Seq_JUKART_Human1.59364490
49TCF7_22412390_ChIP-Seq_EML_Mouse1.58676010
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56477388
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56164820
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55122362
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55062794
54EGR1_19032775_ChIP-ChIP_M12_Human1.51043624
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50288238
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48882417
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.48461860
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.48163986
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47627809
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47439150
61* VDR_24787735_ChIP-Seq_THP-1_Human1.46311474
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.44043898
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43149508
64FOXP3_21729870_ChIP-Seq_TREG_Human1.41654218
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40626712
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36576667
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35502584
68MAF_26560356_Chip-Seq_TH2_Human1.35450245
69* VDR_24763502_ChIP-Seq_THP-1_Human1.34295909
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33896787
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32875803
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.30256745
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29614978
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28440466
75VDR_21846776_ChIP-Seq_THP-1_Human1.26540022
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26499246
77* PU_27001747_Chip-Seq_BMDM_Mouse1.25692137
78GATA3_26560356_Chip-Seq_TH2_Human1.25478592
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.24628061
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.23815446
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23009401
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22237401
83KDM2B_26808549_Chip-Seq_DND41_Human1.19488681
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18635969
85SCL_19346495_ChIP-Seq_HPC-7_Human1.15879587
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15728165
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15728165
88ZNF263_19887448_ChIP-Seq_K562_Human1.13253695
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13178949
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12741282
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12665699
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12473774
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12390243
94GATA1_22025678_ChIP-Seq_K562_Human1.10880739
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.09877918
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09819221
97GABP_19822575_ChIP-Seq_HepG2_Human1.05181575
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04707007
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03967551
100SPI1_23547873_ChIP-Seq_NB4_Human1.03357492
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03170513
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.01604651
103MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99074703
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.98977453
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97754166
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96078852
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.95460784
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94392163
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93614312
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93173972
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.92669922
112KLF4_18555785_Chip-Seq_ESCs_Mouse0.91093115
113* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90828120
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90352931
115SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89180443
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89000499
117MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88971093
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87646445
119ATF3_27146783_Chip-Seq_COLON_Human0.87141515
120CJUN_26792858_Chip-Seq_BT549_Human0.86138581
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86070235
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86065479
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85378448
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85283287
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84987626
126OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83484588
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82897572
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.82818886
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82794920
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82129798
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82115704
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81004395
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79062566
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.78663691
135PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78659847
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78443719
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77032529
138PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.76314500
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.76055179
140* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75004566
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74849487
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.74745604
143SOX2_18555785_Chip-Seq_ESCs_Mouse0.74680861
144ESR2_21235772_ChIP-Seq_MCF-7_Human0.74529426
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74491479
146ESRRB_18555785_Chip-Seq_ESCs_Mouse0.74184789
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73583418
148ELF5_23300383_ChIP-Seq_T47D_Human0.72719703
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72695507
150STAT3_18555785_Chip-Seq_ESCs_Mouse0.72397556
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71696070
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.71252444
153P300_18555785_Chip-Seq_ESCs_Mouse0.70555969
154* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70446204
155NMYC_18555785_Chip-Seq_ESCs_Mouse0.70384691
156EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.68861433
157RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66400475
158AR_21572438_ChIP-Seq_LNCaP_Human0.65858898
159FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64995510
160ELK1_19687146_ChIP-ChIP_HELA_Human0.64928900
161SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.64854139
162GATA6_25053715_ChIP-Seq_YYC3_Human0.62182727
163CDX2_20551321_ChIP-Seq_CACO-2_Human0.61462400
164TAF15_26573619_Chip-Seq_HEK293_Human0.61410690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer6.14406173
2MP0005671_abnormal_response_to4.76924584
3MP0003436_decreased_susceptibility_to4.43764215
4MP0009785_altered_susceptibility_to3.60350452
5MP0001853_heart_inflammation3.59546620
6* MP0001835_abnormal_antigen_presentation3.36647628
7MP0000685_abnormal_immune_system3.20610159
8MP0003763_abnormal_thymus_physiology3.06873615
9MP0003303_peritoneal_inflammation3.03058558
10MP0000465_gastrointestinal_hemorrhage2.96490341
11MP0009333_abnormal_splenocyte_physiolog2.88811511
12* MP0002405_respiratory_system_inflammati2.87926102
13MP0000604_amyloidosis2.80826446
14MP0006082_CNS_inflammation2.78895115
15* MP0005000_abnormal_immune_tolerance2.62100483
16MP0002148_abnormal_hypersensitivity_rea2.61277222
17MP0005387_immune_system_phenotype2.50901472
18MP0001790_abnormal_immune_system2.50901472
19* MP0001800_abnormal_humoral_immune2.50077525
20MP0002723_abnormal_immune_serum2.43749646
21MP0001873_stomach_inflammation2.40365377
22MP0010155_abnormal_intestine_physiology2.37783031
23MP0005025_abnormal_response_to2.36220770
24MP0003186_abnormal_redox_activity2.27765811
25MP0003724_increased_susceptibility_to2.15324703
26* MP0002420_abnormal_adaptive_immunity2.09850031
27MP0002452_abnormal_antigen_presenting2.07816603
28* MP0001819_abnormal_immune_cell2.07598833
29MP0001533_abnormal_skeleton_physiology2.06886805
30MP0003866_abnormal_defecation1.99046959
31MP0004947_skin_inflammation1.94218190
32MP0002398_abnormal_bone_marrow1.91125501
33MP0001501_abnormal_sleep_pattern1.85320208
34* MP0002419_abnormal_innate_immunity1.84489567
35MP0004510_myositis1.77161035
36* MP0001845_abnormal_inflammatory_respons1.75476297
37MP0000716_abnormal_immune_system1.68131451
38MP0002933_joint_inflammation1.63323078
39MP0003448_altered_tumor_morphology1.62793132
40MP0001881_abnormal_mammary_gland1.58745837
41MP0002166_altered_tumor_susceptibility1.54667535
42MP0009764_decreased_sensitivity_to1.50960124
43MP0002138_abnormal_hepatobiliary_system1.48134170
44* MP0000689_abnormal_spleen_morphology1.44271805
45MP0002006_tumorigenesis1.44061165
46MP0000703_abnormal_thymus_morphology1.42620789
47* MP0002722_abnormal_immune_system1.41623241
48MP0002429_abnormal_blood_cell1.37199582
49MP0010307_abnormal_tumor_latency1.32032548
50MP0003329_amyloid_beta_deposits1.31492113
51MP0005076_abnormal_cell_differentiation1.30320780
52MP0003453_abnormal_keratinocyte_physiol1.26995091
53MP0002132_abnormal_respiratory_system1.26413912
54MP0005166_decreased_susceptibility_to1.26053691
55MP0009780_abnormal_chondrocyte_physiolo1.17679134
56MP0008569_lethality_at_weaning1.15668832
57MP0002998_abnormal_bone_remodeling1.14562542
58MP0005501_abnormal_skin_physiology1.12994897
59* MP0004782_abnormal_surfactant_physiolog1.11702740
60MP0008469_abnormal_protein_level1.11648243
61MP0004808_abnormal_hematopoietic_stem1.11265461
62MP0003950_abnormal_plasma_membrane1.10132218
63MP0000858_altered_metastatic_potential1.09054428
64MP0005165_increased_susceptibility_to1.08984495
65MP0000343_altered_response_to1.06142563
66MP0005390_skeleton_phenotype1.05897906
67MP0005464_abnormal_platelet_physiology1.04682089
68MP0003656_abnormal_erythrocyte_physiolo1.01636426
69MP0004147_increased_porphyrin_level0.98078445
70MP0010352_gastrointestinal_tract_polyps0.97013705
71MP0002396_abnormal_hematopoietic_system0.94594746
72MP0008961_abnormal_basal_metabolism0.90608789
73MP0000609_abnormal_liver_physiology0.90206231
74MP0001663_abnormal_digestive_system0.89903948
75MP0001727_abnormal_embryo_implantation0.89472842
76MP0000249_abnormal_blood_vessel0.88079318
77MP0001851_eye_inflammation0.87911986
78MP0000627_abnormal_mammary_gland0.85947962
79MP0005023_abnormal_wound_healing0.85541005
80MP0000490_abnormal_crypts_of0.82845002
81MP0009697_abnormal_copulation0.80671700
82MP0003075_altered_response_to0.77618059
83MP0002254_reproductive_system_inflammat0.76592692
84MP0002877_abnormal_melanocyte_morpholog0.76522855
85MP0003806_abnormal_nucleotide_metabolis0.76522365
86MP0003195_calcinosis0.75291540
87MP0008057_abnormal_DNA_replication0.75089031
88MP0009763_increased_sensitivity_to0.74958972
89MP0009765_abnormal_xenobiotic_induced0.74344164
90MP0005319_abnormal_enzyme/_coenzyme0.71760364
91MP0008875_abnormal_xenobiotic_pharmacok0.71730379
92MP0003795_abnormal_bone_structure0.68648447
93MP0003936_abnormal_reproductive_system0.68006942
94MP0003091_abnormal_cell_migration0.65924788
95MP0002282_abnormal_trachea_morphology0.63735509
96MP0003566_abnormal_cell_adhesion0.57427750
97MP0005397_hematopoietic_system_phenotyp0.56474288
98MP0001545_abnormal_hematopoietic_system0.56474288
99* MP0002019_abnormal_tumor_incidence0.56214407
100MP0002693_abnormal_pancreas_physiology0.55894988
101MP0005164_abnormal_response_to0.55465686
102MP0001216_abnormal_epidermal_layer0.53220831
103MP0003786_premature_aging0.51868150
104MP0002234_abnormal_pharynx_morphology0.51526423
105MP0005381_digestive/alimentary_phenotyp0.49742438
106MP0009840_abnormal_foam_cell0.49265438
107MP0002277_abnormal_respiratory_mucosa0.47965916
108* MP0002136_abnormal_kidney_physiology0.44650605
109MP0009643_abnormal_urine_homeostasis0.44431829
110MP0008770_decreased_survivor_rate0.43894231
111MP0000598_abnormal_liver_morphology0.43420916
112MP0010771_integument_phenotype0.42933065
113MP0003943_abnormal_hepatobiliary_system0.42445277
114MP0008872_abnormal_physiological_respon0.41525204
115MP0001348_abnormal_lacrimal_gland0.40252096
116MP0004142_abnormal_muscle_tone0.39722830
117MP0000477_abnormal_intestine_morphology0.38620699
118MP0008873_increased_physiological_sensi0.38002761
119MP0001243_abnormal_dermal_layer0.37957710
120MP0005310_abnormal_salivary_gland0.37849406
121MP0002089_abnormal_postnatal_growth/wei0.37377084
122MP0008007_abnormal_cellular_replicative0.35814566
123MP0002736_abnormal_nociception_after0.28865801
124MP0001502_abnormal_circadian_rhythm0.25658343
125MP0005636_abnormal_mineral_homeostasis0.24939694
126MP0003718_maternal_effect0.23823850
127MP0001764_abnormal_homeostasis0.23537766
128MP0001919_abnormal_reproductive_system0.22516784

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.09873064
2Retrobulbar optic neuritis (HP:0100654)6.89528555
3Optic neuritis (HP:0100653)6.89528555
4Orchitis (HP:0100796)6.23041953
5Myositis (HP:0100614)5.81917054
6T lymphocytopenia (HP:0005403)5.36797317
7Elevated erythrocyte sedimentation rate (HP:0003565)5.29097974
8Abnormality of T cell number (HP:0011839)5.25372084
9Increased density of long bones (HP:0006392)5.18501314
10Keratoconjunctivitis sicca (HP:0001097)4.75545436
11Persistence of primary teeth (HP:0006335)4.67934769
12Arterial thrombosis (HP:0004420)4.55505597
13Abnormality of the pons (HP:0007361)4.45763614
14Biconcave vertebral bodies (HP:0004586)4.35899573
15Keratoconjunctivitis (HP:0001096)4.30736768
16Hypoplasia of the pons (HP:0012110)4.00906894
17Pulmonary infiltrates (HP:0002113)3.98608942
18Interstitial pulmonary disease (HP:0006530)3.91338053
19Nasal polyposis (HP:0100582)3.90251305
20Autoimmune hemolytic anemia (HP:0001890)3.82927779
21Eczematoid dermatitis (HP:0000976)3.79650409
22Glucose intolerance (HP:0000833)3.76890293
23Gastrointestinal infarctions (HP:0005244)3.75163545
24Abnormality of T cells (HP:0002843)3.70431057
25IgA deficiency (HP:0002720)3.66592215
26Joint swelling (HP:0001386)3.55452211
27Mediastinal lymphadenopathy (HP:0100721)3.40425688
28Delayed epiphyseal ossification (HP:0002663)3.39479639
29Severe combined immunodeficiency (HP:0004430)3.29783667
30Carpal bone hypoplasia (HP:0001498)3.23966569
31Abnormality of the nasal mucosa (HP:0000433)3.23530393
32Recurrent fungal infections (HP:0002841)3.20399551
33Vasculitis (HP:0002633)3.07071095
34Thrombocytosis (HP:0001894)2.97568985
35Recurrent bronchitis (HP:0002837)2.97267969
36Recurrent viral infections (HP:0004429)2.96539861
37Epiphyseal dysplasia (HP:0002656)2.92654841
38Autoimmune thrombocytopenia (HP:0001973)2.91125423
39Increased serum pyruvate (HP:0003542)2.90301961
40Increased hepatocellular lipid droplets (HP:0006565)2.89995800
41Combined immunodeficiency (HP:0005387)2.88963769
42Abnormality of B cell number (HP:0010975)2.88506482
43B lymphocytopenia (HP:0010976)2.88506482
44Cutaneous melanoma (HP:0012056)2.86521522
45Type I transferrin isoform profile (HP:0003642)2.86100509
46Flat capital femoral epiphysis (HP:0003370)2.83034930
47Muscle fiber atrophy (HP:0100295)2.82657514
48Anorexia (HP:0002039)2.80641991
49Hypoproteinemia (HP:0003075)2.78431344
50Vitreoretinal degeneration (HP:0000655)2.74449370
51Mitochondrial inheritance (HP:0001427)2.73738241
52IgM deficiency (HP:0002850)2.73200601
53IgG deficiency (HP:0004315)2.72721204
54Pulmonary embolism (HP:0002204)2.71471967
55Gangrene (HP:0100758)2.69713618
56Hemoptysis (HP:0002105)2.69001711
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68194430
58Type 2 muscle fiber atrophy (HP:0003554)2.66492553
59Deep palmar crease (HP:0006191)2.63880207
60Chronic diarrhea (HP:0002028)2.62379744
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61955748
62Myocardial infarction (HP:0001658)2.60040026
63Attenuation of retinal blood vessels (HP:0007843)2.59583262
64Lipid accumulation in hepatocytes (HP:0006561)2.56726336
65Reduced antithrombin III activity (HP:0001976)2.56620848
66Irregular vertebral endplates (HP:0003301)2.52863089
67Abnormal glucose tolerance (HP:0001952)2.52513154
68Acute necrotizing encephalopathy (HP:0006965)2.51872503
69Abnormal rod and cone electroretinograms (HP:0008323)2.51376522
70Thrombophlebitis (HP:0004418)2.49430562
71Arthralgia (HP:0002829)2.48099535
72Vertebral compression fractures (HP:0002953)2.46311682
73Small epiphyses (HP:0010585)2.46033613
74Esophageal varix (HP:0002040)2.44586640
75Pustule (HP:0200039)2.43383145
76Pulmonary fibrosis (HP:0002206)2.38411179
77Encephalitis (HP:0002383)2.37971816
78Chronic otitis media (HP:0000389)2.36075825
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.35266494
80Increased CSF lactate (HP:0002490)2.35078350
81Abnormality of the prostate (HP:0008775)2.34233356
82Abnormality of glycolysis (HP:0004366)2.33238636
83Chronic mucocutaneous candidiasis (HP:0002728)2.33063472
84Recurrent cutaneous fungal infections (HP:0011370)2.33063472
85Metaphyseal irregularity (HP:0003025)2.31911102
86Leukocytosis (HP:0001974)2.30794355
87Abnormality of T cell physiology (HP:0011840)2.30741960
88Aplastic anemia (HP:0001915)2.30418602
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29768839
90Exertional dyspnea (HP:0002875)2.29520531
91Chest pain (HP:0100749)2.27626653
92Increased IgM level (HP:0003496)2.27268792
93Renal Fanconi syndrome (HP:0001994)2.25404054
94Premature loss of primary teeth (HP:0006323)2.23614817
95Posterior subcapsular cataract (HP:0007787)2.22723913
96Ureteral stenosis (HP:0000071)2.21807593
97Cupped ribs (HP:0000887)2.21120945
98Hypergammaglobulinemia (HP:0010702)2.20274406
99Oligomenorrhea (HP:0000876)2.19876601
100Abnormality of the proximal phalanges of the hand (HP:0009834)2.19771230
101Hepatocellular necrosis (HP:0001404)2.18951600
102Peritonitis (HP:0002586)2.18596581
103Gingival bleeding (HP:0000225)2.17475023
104Abnormal mitochondria in muscle tissue (HP:0008316)2.16726142
105Abnormality of the vertebral endplates (HP:0005106)2.15103302
106Glossoptosis (HP:0000162)2.14242353
107Keratitis (HP:0000491)2.13425299
108Abnormality of cells of the lymphoid lineage (HP:0012140)2.12712570
109Cerebral hypomyelination (HP:0006808)2.12512658
110Submucous cleft hard palate (HP:0000176)2.11265765
111Abnormality of the pleura (HP:0002103)2.10336371
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09419340
113Glomerulopathy (HP:0100820)2.08899621
114Abnormality of the pericardium (HP:0001697)2.08685232
115Irregular epiphyses (HP:0010582)2.07909148
116Hypertensive crisis (HP:0100735)2.07029297
117Fatigue (HP:0012378)2.06318157
118Meningitis (HP:0001287)2.06262442
119Aseptic necrosis (HP:0010885)2.06083648
120Recurrent abscess formation (HP:0002722)2.06045176
121Depressed nasal tip (HP:0000437)2.05704394
122Lymphoma (HP:0002665)2.04846861
123Thoracolumbar scoliosis (HP:0002944)2.04467225
124Amaurosis fugax (HP:0100576)2.03928723
125Abnormality of the nasal septum (HP:0000419)2.03054703
126Abnormality of eosinophils (HP:0001879)2.01501044
127Abnormal albumin level (HP:0012116)2.00853232
128Hypoalbuminemia (HP:0003073)2.00853232
129Ureteral obstruction (HP:0006000)2.00574500
130Progressive macrocephaly (HP:0004481)2.00494384
131Panhypogammaglobulinemia (HP:0003139)1.99089355
132Acute myeloid leukemia (HP:0004808)1.97330950
133Enlarged epiphyses (HP:0010580)1.96934954
134Abnormal protein glycosylation (HP:0012346)1.96436803
135Abnormal glycosylation (HP:0012345)1.96436803
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96436803
137Abnormal protein N-linked glycosylation (HP:0012347)1.96436803
138Vertigo (HP:0002321)1.96379817
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95832394
140Exercise intolerance (HP:0003546)1.95220267
141Abnormality of macrophages (HP:0004311)1.94946173
142Increased intramyocellular lipid droplets (HP:0012240)1.94184514
143Obstructive lung disease (HP:0006536)1.93864167
144Chronic obstructive pulmonary disease (HP:0006510)1.93864167
145Hypoplastic ischia (HP:0003175)1.93792705
146Acute encephalopathy (HP:0006846)1.93688459
147Increased serum lactate (HP:0002151)1.92584146
148Recurrent bacterial skin infections (HP:0005406)1.90926274
149Somatic mutation (HP:0001428)1.90909325
150Gastrointestinal stroma tumor (HP:0100723)1.90262179
151Osteolytic defects of the hand bones (HP:0009699)1.89587622
152Osteolytic defects of the phalanges of the hand (HP:0009771)1.89587622
153Subacute progressive viral hepatitis (HP:0006572)1.87494080
154Periodontitis (HP:0000704)1.87386282
155Thyroiditis (HP:0100646)1.87080198
156Hepatosplenomegaly (HP:0001433)1.81587739
157Arthropathy (HP:0003040)1.81096649
158Polyneuropathy (HP:0001271)1.77887336
159Eosinophilia (HP:0001880)1.77278226
160Absent frontal sinuses (HP:0002688)1.76631769
161Nausea (HP:0002018)1.75340670
162Restrictive lung disease (HP:0002091)1.75329977
163Abnormality of the peritoneum (HP:0002585)1.71460254
164Polycythemia (HP:0001901)1.70926669
165Diplopia (HP:0000651)1.68872686
166Abnormality of binocular vision (HP:0011514)1.68872686
167Stenosis of the external auditory canal (HP:0000402)1.66353722
168Lymphopenia (HP:0001888)1.65581554
169Anhidrosis (HP:0000970)1.65401139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.96078127
2MAP4K15.36288243
3EIF2AK34.96201680
4MAP3K143.74149306
5EIF2AK13.63462779
6ITK3.29127631
7ZAP702.97809007
8JAK32.87320859
9TEC2.31986411
10PIM22.31763956
11IRAK32.21559285
12IKBKB2.16033137
13TSSK62.07498466
14TBK12.04744043
15CHUK2.03965313
16MAP3K31.99636524
17MST41.89194270
18CSK1.88886528
19MAP2K61.76564813
20BUB11.76275013
21FLT31.71265236
22EIF2AK21.69423349
23STK101.69315188
24WNK11.69254840
25IKBKE1.66172888
26TNK21.64651673
27JAK11.63378494
28PIM11.62135584
29EPHB11.60231902
30ADRBK21.58570487
31TAOK31.53815455
32CAMKK21.48731068
33TYK21.36316378
34MAP3K111.35768272
35BTK1.34104842
36VRK21.34071549
37HCK1.23160012
38TAOK11.17926677
39NME11.16655016
40BMX1.11636255
41FGFR41.11273435
42LCK1.10947872
43EEF2K1.09499179
44CLK11.04160531
45SYK1.02200408
46GSK3A1.01684371
47LRRK20.97741011
48PRKD30.96048941
49EPHA30.95494487
50GRK70.91461947
51MAP3K120.90355255
52TAOK20.89032674
53ALK0.88120565
54FGFR30.87861617
55RAF10.84357687
56STK240.84350389
57RPS6KB20.83224907
58ERBB30.82248399
59JAK20.78616830
60MAP2K30.75267248
61PRKCQ0.72834618
62TRIB30.72268833
63VRK10.70309729
64FES0.69732354
65PAK20.69101292
66GRK60.68484528
67LYN0.68448222
68AKT30.67681246
69MAP3K70.67395183
70FGFR10.64885652
71RPS6KA40.64504841
72BLK0.63625144
73BCKDK0.63406941
74PTK60.63168865
75MST1R0.60887717
76RIPK10.60431748
77BMPR20.59476590
78SIK20.59412272
79PRKCH0.58521437
80PAK40.58039865
81GRK10.57190335
82TGFBR20.56884070
83IRAK40.54038156
84EPHA20.52532321
85EGFR0.52397520
86MAP2K70.52248031
87CDK60.50982049
88MAP3K80.50639304
89PDGFRB0.50405789
90KIT0.48533361
91NME20.48181960
92MELK0.45946454
93PRKG20.45795540
94INSR0.45282745
95NEK90.43497604
96ABL10.43029187
97PLK30.42226804
98CDK80.41975595
99IGF1R0.41278022
100MAP3K100.40675403
101MAP3K50.40621902
102NUAK10.38278009
103CAMKK10.37396981
104ADRBK10.37334233
105MAPK150.36770307
106KDR0.36700254
107RPS6KA10.36425517
108MAPKAPK20.35226426
109RPS6KA50.33097417
110MKNK20.32335632
111CDK120.30634160
112ABL20.30061341
113ROCK20.29973321
114PKN20.29959210
115MAP3K130.29563451
116SIK30.28265038
117MAP3K10.28022341
118PKN10.26237244
119BMPR1B0.26161483
120TGFBR10.23941889
121MTOR0.23409372
122CSNK2A20.23368196
123CDK40.22954956
124NEK10.22787647
125RPS6KB10.22287768
126ZAK0.22009591
127NLK0.21940772
128STK40.21611286
129TLK10.21069904
130PDK10.20121705
131LMTK20.18620564
132PLK10.18586195
133PRKCD0.18516993
134PAK10.16824535
135PRKCB0.16241738
136PRKCA0.15947169
137MAPK40.15112478
138MARK30.12956151
139FGR0.12683384
140MATK0.11538597
141BCR0.08770182
142CSNK2A10.08209761
143PINK10.07989073
144ERBB40.07720566

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.35656625
2Allograft rejection_Homo sapiens_hsa053305.83501496
3Graft-versus-host disease_Homo sapiens_hsa053325.79685509
4Asthma_Homo sapiens_hsa053104.96018668
5Type I diabetes mellitus_Homo sapiens_hsa049404.91647980
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.04198201
7Regulation of autophagy_Homo sapiens_hsa041403.14979815
8Autoimmune thyroid disease_Homo sapiens_hsa053202.87900703
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.73535289
10* T cell receptor signaling pathway_Homo sapiens_hsa046602.40524804
11* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.26087492
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.25036428
13Leishmaniasis_Homo sapiens_hsa051402.04705948
14Protein export_Homo sapiens_hsa030602.04021430
15* Jak-STAT signaling pathway_Homo sapiens_hsa046302.01125138
16* Hematopoietic cell lineage_Homo sapiens_hsa046401.90892394
17Measles_Homo sapiens_hsa051621.87953571
18Antigen processing and presentation_Homo sapiens_hsa046121.86761698
19* TNF signaling pathway_Homo sapiens_hsa046681.72140338
20Malaria_Homo sapiens_hsa051441.65507269
21Osteoclast differentiation_Homo sapiens_hsa043801.57683471
22* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50004041
23Legionellosis_Homo sapiens_hsa051341.49714528
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48775322
25African trypanosomiasis_Homo sapiens_hsa051431.43791761
26Primary immunodeficiency_Homo sapiens_hsa053401.43751941
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42793703
28Toxoplasmosis_Homo sapiens_hsa051451.35849114
29* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34949518
30Apoptosis_Homo sapiens_hsa042101.29042723
31* Rheumatoid arthritis_Homo sapiens_hsa053231.25523968
32Chemokine signaling pathway_Homo sapiens_hsa040621.22533762
33Herpes simplex infection_Homo sapiens_hsa051681.06583768
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05073634
35Pertussis_Homo sapiens_hsa051331.05035952
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03765884
37RNA polymerase_Homo sapiens_hsa030201.01502130
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93562235
39Tuberculosis_Homo sapiens_hsa051520.86688700
40Influenza A_Homo sapiens_hsa051640.85853634
41B cell receptor signaling pathway_Homo sapiens_hsa046620.84218121
42Basal transcription factors_Homo sapiens_hsa030220.82763925
43Systemic lupus erythematosus_Homo sapiens_hsa053220.82261910
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79454726
45* HTLV-I infection_Homo sapiens_hsa051660.79335963
46Hepatitis B_Homo sapiens_hsa051610.78970283
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77555023
48Folate biosynthesis_Homo sapiens_hsa007900.74222279
49* Salmonella infection_Homo sapiens_hsa051320.73988712
50* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73722233
51Acute myeloid leukemia_Homo sapiens_hsa052210.71082807
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67890786
53Epstein-Barr virus infection_Homo sapiens_hsa051690.66159826
54Viral myocarditis_Homo sapiens_hsa054160.65689622
55Viral carcinogenesis_Homo sapiens_hsa052030.63817323
56Chronic myeloid leukemia_Homo sapiens_hsa052200.63630808
57* Amoebiasis_Homo sapiens_hsa051460.61516064
58Small cell lung cancer_Homo sapiens_hsa052220.59071163
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.58628637
60Prolactin signaling pathway_Homo sapiens_hsa049170.58407717
61Pyrimidine metabolism_Homo sapiens_hsa002400.57350025
62Shigellosis_Homo sapiens_hsa051310.56881562
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53934492
64Fructose and mannose metabolism_Homo sapiens_hsa000510.50609283
65Staphylococcus aureus infection_Homo sapiens_hsa051500.48671282
66MAPK signaling pathway_Homo sapiens_hsa040100.46184872
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.45870389
68Hepatitis C_Homo sapiens_hsa051600.44294496
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38387186
70Circadian rhythm_Homo sapiens_hsa047100.35135624
71Pancreatic cancer_Homo sapiens_hsa052120.34978567
72TGF-beta signaling pathway_Homo sapiens_hsa043500.34928105
73HIF-1 signaling pathway_Homo sapiens_hsa040660.34693302
74Oxidative phosphorylation_Homo sapiens_hsa001900.33545112
75MicroRNAs in cancer_Homo sapiens_hsa052060.33257848
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.33235715
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31928872
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31623240
79Vitamin B6 metabolism_Homo sapiens_hsa007500.31189120
80Mineral absorption_Homo sapiens_hsa049780.29488864
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27105696
82Proteoglycans in cancer_Homo sapiens_hsa052050.26895538
83VEGF signaling pathway_Homo sapiens_hsa043700.26518704
84RNA transport_Homo sapiens_hsa030130.25179829
85N-Glycan biosynthesis_Homo sapiens_hsa005100.25031150
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24032284
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23366365
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23042633
89p53 signaling pathway_Homo sapiens_hsa041150.20944530
90One carbon pool by folate_Homo sapiens_hsa006700.20629952
91Insulin resistance_Homo sapiens_hsa049310.19677403
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19233493
93Parkinsons disease_Homo sapiens_hsa050120.18718237
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18705760
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18095065
96Colorectal cancer_Homo sapiens_hsa052100.17173135
97mTOR signaling pathway_Homo sapiens_hsa041500.16850052
98Platelet activation_Homo sapiens_hsa046110.16789977
99Ribosome_Homo sapiens_hsa030100.16604619
100Nucleotide excision repair_Homo sapiens_hsa034200.16483698
101Homologous recombination_Homo sapiens_hsa034400.15890392
102Sulfur metabolism_Homo sapiens_hsa009200.15617059
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15350407
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15055791
105Spliceosome_Homo sapiens_hsa030400.14903408
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14169249
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.12480595
108Type II diabetes mellitus_Homo sapiens_hsa049300.12280020
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12040094
110Renal cell carcinoma_Homo sapiens_hsa052110.11862933
111RNA degradation_Homo sapiens_hsa030180.09890839
112ECM-receptor interaction_Homo sapiens_hsa045120.09775989
113Endocytosis_Homo sapiens_hsa041440.09277761
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08940248
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08307018
116Steroid biosynthesis_Homo sapiens_hsa001000.08210382
117FoxO signaling pathway_Homo sapiens_hsa040680.08099799
118Butanoate metabolism_Homo sapiens_hsa006500.05651124
119Linoleic acid metabolism_Homo sapiens_hsa005910.05297428
120Prostate cancer_Homo sapiens_hsa052150.05185915
121Purine metabolism_Homo sapiens_hsa002300.03471263
122Peroxisome_Homo sapiens_hsa041460.02791262
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.02680230
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.02670734
125Prion diseases_Homo sapiens_hsa050200.02475580
126Bladder cancer_Homo sapiens_hsa052190.01950198
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.01823476
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01446394
129Pathways in cancer_Homo sapiens_hsa052000.01422052
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.01403524
131ErbB signaling pathway_Homo sapiens_hsa040120.00915307
132Focal adhesion_Homo sapiens_hsa045100.00525021
133Phagosome_Homo sapiens_hsa041450.00374808
134Metabolic pathways_Homo sapiens_hsa01100-0.1030140
135Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0857631
136Phototransduction_Homo sapiens_hsa04744-0.0671003
137Alzheimers disease_Homo sapiens_hsa05010-0.0629039
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0549419
139Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0507447
140Collecting duct acid secretion_Homo sapiens_hsa04966-0.0457863
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0303512
142Lysosome_Homo sapiens_hsa04142-0.0300825
143Cyanoamino acid metabolism_Homo sapiens_hsa00460-0.0187854

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