CSAG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.93326000
2regulation of retinoic acid receptor signaling pathway (GO:0048385)7.71485561
3synapsis (GO:0007129)5.65822738
4maturation of 5.8S rRNA (GO:0000460)5.18265618
5negative regulation of protein acetylation (GO:1901984)4.86768807
6nuclear pore complex assembly (GO:0051292)4.63850644
7DNA replication checkpoint (GO:0000076)4.10047605
8proteasome assembly (GO:0043248)3.99404641
9histone H2A acetylation (GO:0043968)3.87136475
10nuclear pore organization (GO:0006999)3.85652463
11mitochondrial DNA replication (GO:0006264)3.76634296
12protein deneddylation (GO:0000338)3.74050228
13binding of sperm to zona pellucida (GO:0007339)3.73434353
14ribosome assembly (GO:0042255)3.72746417
15aminoglycoside antibiotic metabolic process (GO:0030647)3.67877571
16DNA catabolic process, exonucleolytic (GO:0000738)3.65068888
17folic acid metabolic process (GO:0046655)3.60591327
18phosphate ion transport (GO:0006817)3.59509315
19mitotic nuclear envelope disassembly (GO:0007077)3.59351334
20urate metabolic process (GO:0046415)3.58748929
21resolution of meiotic recombination intermediates (GO:0000712)3.57597906
22rRNA methylation (GO:0031167)3.57260473
23negative regulation of histone acetylation (GO:0035067)3.52145647
24DNA double-strand break processing (GO:0000729)3.46414280
25cullin deneddylation (GO:0010388)3.41330832
26DNA methylation involved in gamete generation (GO:0043046)3.37642734
27formation of translation preinitiation complex (GO:0001731)3.37537833
28telomere maintenance via semi-conservative replication (GO:0032201)3.36132247
29rRNA modification (GO:0000154)3.31921468
30positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30882243
31mRNA cleavage (GO:0006379)3.28206413
32pore complex assembly (GO:0046931)3.25486228
33regulation of translational fidelity (GO:0006450)3.23224256
34oxidative demethylation (GO:0070989)3.17097192
35membrane disassembly (GO:0030397)3.16812269
36nuclear envelope disassembly (GO:0051081)3.16812269
37positive regulation of ligase activity (GO:0051351)3.12208648
38phosphate ion transmembrane transport (GO:0035435)3.10201915
39diterpenoid biosynthetic process (GO:0016102)3.10077711
40regulation of RNA export from nucleus (GO:0046831)3.09927725
41glycoside metabolic process (GO:0016137)3.09141029
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05852749
43meiotic chromosome segregation (GO:0045132)3.05802092
44regulation of cellular amino acid metabolic process (GO:0006521)3.05455371
45mitochondrial DNA metabolic process (GO:0032042)3.04546982
46response to misfolded protein (GO:0051788)3.03442696
47ribosomal large subunit biogenesis (GO:0042273)3.01829300
48misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.01406377
49male meiosis (GO:0007140)2.99202326
50water-soluble vitamin biosynthetic process (GO:0042364)2.96559016
51regulation of ubiquitin-protein transferase activity (GO:0051438)2.95866807
52DNA replication initiation (GO:0006270)2.95304316
53sperm-egg recognition (GO:0035036)2.93864661
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93549100
55telomere maintenance via recombination (GO:0000722)2.91401950
56pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.89921205
57UMP metabolic process (GO:0046049)2.89921205
58pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.89921205
59UMP biosynthetic process (GO:0006222)2.89921205
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89885818
61DNA strand elongation involved in DNA replication (GO:0006271)2.89870215
62chromosome organization involved in meiosis (GO:0070192)2.88430338
63folic acid-containing compound metabolic process (GO:0006760)2.86706700
64fusion of sperm to egg plasma membrane (GO:0007342)2.86323276
65negative regulation of ligase activity (GO:0051352)2.84708196
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84708196
67biotin metabolic process (GO:0006768)2.83268801
68lipopolysaccharide biosynthetic process (GO:0009103)2.82085255
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81864698
70urea metabolic process (GO:0019627)2.81838442
71TOR signaling (GO:0031929)2.81708438
72regulation of ligase activity (GO:0051340)2.81621760
73ribosome biogenesis (GO:0042254)2.81162409
74DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80155950
75short-chain fatty acid metabolic process (GO:0046459)2.79979785
76DNA strand elongation (GO:0022616)2.79281944
77transcription from mitochondrial promoter (GO:0006390)2.77983547
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77736242
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77736242
80negative regulation of peptidyl-lysine acetylation (GO:2000757)2.77328254
81hyperosmotic salinity response (GO:0042538)2.77225533
82DNA topological change (GO:0006265)2.76700120
83piRNA metabolic process (GO:0034587)2.71910799
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70312205
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70312205
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70312205
87pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.69373492
88alkaloid metabolic process (GO:0009820)2.68519540
89regulation of response to osmotic stress (GO:0047484)2.67852588
90urea cycle (GO:0000050)2.66681013
91dopamine transport (GO:0015872)2.66561171
92valine metabolic process (GO:0006573)2.66426556
93telomere maintenance via telomere lengthening (GO:0010833)2.66001722
94retinal metabolic process (GO:0042574)2.65434875
95tetrahydrofolate metabolic process (GO:0046653)2.63424079
96regulation of mitochondrial translation (GO:0070129)2.63265965
97terpenoid biosynthetic process (GO:0016114)2.62605207
98glycine metabolic process (GO:0006544)2.62102539
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.61933611
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.61933611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.14193132
2E2F7_22180533_ChIP-Seq_HELA_Human4.61309022
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55308439
4ZNF263_19887448_ChIP-Seq_K562_Human3.72986695
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.52651858
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.46461278
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45621977
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34608970
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.10488050
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.03457566
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87003890
12ELK1_19687146_ChIP-ChIP_HELA_Human2.86791246
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.82175712
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76775622
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61801401
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.59238115
17AR_21909140_ChIP-Seq_LNCAP_Human2.53934764
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44681268
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42291669
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40573721
21VDR_22108803_ChIP-Seq_LS180_Human2.36602166
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.23073170
23DCP1A_22483619_ChIP-Seq_HELA_Human2.22260429
24VDR_23849224_ChIP-Seq_CD4+_Human2.18353787
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17084896
26FOXP3_21729870_ChIP-Seq_TREG_Human1.99550686
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96583819
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92319901
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87626804
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80949406
31CIITA_25753668_ChIP-Seq_RAJI_Human1.79242311
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.77362730
33GABP_19822575_ChIP-Seq_HepG2_Human1.72211423
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68672116
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67875391
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65290950
37TTF2_22483619_ChIP-Seq_HELA_Human1.64508185
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61970080
39KDM5A_27292631_Chip-Seq_BREAST_Human1.61734665
40XRN2_22483619_ChIP-Seq_HELA_Human1.60616431
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57596392
42MYC_18940864_ChIP-ChIP_HL60_Human1.57508171
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57430026
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53883215
45NCOR1_26117541_ChIP-Seq_K562_Human1.47255302
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44620627
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42435927
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.42119460
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42028887
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41929787
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36576934
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36376133
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36001290
54GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.35295344
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.35237080
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32748700
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31391679
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.31238399
59RBPJ_21746931_ChIP-Seq_IB4_Human1.28466201
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26821075
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25876796
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23719615
63PHF8_20622853_ChIP-Seq_HELA_Human1.22451538
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21421655
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.17971648
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17773813
67CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14619751
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13465580
69ETV1_20927104_ChIP-Seq_GIST48_Human1.12023854
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.10257130
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07084590
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05625443
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02692737
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00114644
75RAC3_21632823_ChIP-Seq_H3396_Human0.98210973
76ELF5_23300383_ChIP-Seq_T47D_Human0.96195985
77EWS_26573619_Chip-Seq_HEK293_Human0.96161025
78TFEB_21752829_ChIP-Seq_HELA_Human0.93505659
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92944119
80RXR_22158963_ChIP-Seq_LIVER_Mouse0.92789600
81ER_23166858_ChIP-Seq_MCF-7_Human0.91294429
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90221047
83NFYB_21822215_ChIP-Seq_K562_Human0.89868443
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88657918
85E2F1_20622854_ChIP-Seq_HELA_Human0.88452642
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88208241
87ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88170026
88P53_21459846_ChIP-Seq_SAOS-2_Human0.86426241
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85301717
90PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83679422
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83156987
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82302875
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.81399596
94NCOR_22424771_ChIP-Seq_293T_Human0.81118286
95ZNF274_21170338_ChIP-Seq_K562_Hela0.81088233
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.80557096
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80149002
98NFYA_21822215_ChIP-Seq_K562_Human0.79312540
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77717876
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77294783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation4.65739217
2MP0005360_urolithiasis4.15977295
3MP0004147_increased_porphyrin_level3.91409361
4MP0002138_abnormal_hepatobiliary_system3.54861751
5MP0008058_abnormal_DNA_repair3.27000903
6MP0003806_abnormal_nucleotide_metabolis3.17039317
7MP0003111_abnormal_nucleus_morphology2.92543632
8MP0003786_premature_aging2.90096577
9MP0005171_absent_coat_pigmentation2.78089863
10MP0005085_abnormal_gallbladder_physiolo2.74875749
11MP0008875_abnormal_xenobiotic_pharmacok2.63960222
12MP0002139_abnormal_hepatobiliary_system2.51168604
13MP0001764_abnormal_homeostasis2.41914530
14MP0005410_abnormal_fertilization2.38422338
15MP0006036_abnormal_mitochondrial_physio2.33588848
16MP0004957_abnormal_blastocyst_morpholog2.30257787
17MP0002160_abnormal_reproductive_system2.29758880
18MP0008995_early_reproductive_senescence2.25098948
19MP0010094_abnormal_chromosome_stability2.20528410
20MP0001545_abnormal_hematopoietic_system2.06214389
21MP0005397_hematopoietic_system_phenotyp2.06214389
22MP0003718_maternal_effect1.89634704
23MP0008775_abnormal_heart_ventricle1.79269011
24MP0005332_abnormal_amino_acid1.77995706
25MP0006035_abnormal_mitochondrial_morpho1.73948705
26MP0003077_abnormal_cell_cycle1.73856925
27MP0005083_abnormal_biliary_tract1.73427357
28MP0005389_reproductive_system_phenotype1.71459544
29MP0005365_abnormal_bile_salt1.70944502
30MP0001929_abnormal_gametogenesis1.62900847
31MP0003868_abnormal_feces_composition1.62822009
32MP0008007_abnormal_cellular_replicative1.61238916
33MP0002876_abnormal_thyroid_physiology1.60958352
34MP0004019_abnormal_vitamin_homeostasis1.60952706
35MP0000372_irregular_coat_pigmentation1.59342645
36MP0004808_abnormal_hematopoietic_stem1.55600667
37MP0003186_abnormal_redox_activity1.52952264
38MP0008932_abnormal_embryonic_tissue1.51760307
39MP0002938_white_spotting1.46633599
40MP0005646_abnormal_pituitary_gland1.43250335
41MP0002210_abnormal_sex_determination1.39621439
42MP0003195_calcinosis1.39150105
43MP0010386_abnormal_urinary_bladder1.34335066
44MP0002132_abnormal_respiratory_system1.31416850
45MP0010307_abnormal_tumor_latency1.29379761
46MP0004084_abnormal_cardiac_muscle1.25848114
47MP0000653_abnormal_sex_gland1.24312784
48MP0006292_abnormal_olfactory_placode1.23734702
49MP0005645_abnormal_hypothalamus_physiol1.22859926
50MP0003698_abnormal_male_reproductive1.20523750
51MP0000678_abnormal_parathyroid_gland1.20223777
52MP0000747_muscle_weakness1.16852516
53MP0001661_extended_life_span1.15246873
54MP0001145_abnormal_male_reproductive1.14035706
55MP0005395_other_phenotype1.11675944
56MP0001881_abnormal_mammary_gland1.10673375
57MP0005319_abnormal_enzyme/_coenzyme1.09869094
58MP0000749_muscle_degeneration1.07324911
59MP0004782_abnormal_surfactant_physiolog1.03146334
60MP0005636_abnormal_mineral_homeostasis1.02097255
61MP0003693_abnormal_embryo_hatching1.01839525
62MP0003136_yellow_coat_color0.94092105
63MP0008872_abnormal_physiological_respon0.93832329
64MP0001697_abnormal_embryo_size0.93251686
65MP0003045_fibrosis0.92850679
66MP0002161_abnormal_fertility/fecundity0.91869471
67MP0001919_abnormal_reproductive_system0.90735282
68MP0000681_abnormal_thyroid_gland0.89481395
69MP0005647_abnormal_sex_gland0.89365787
70MP0003252_abnormal_bile_duct0.87825570
71MP0002090_abnormal_vision0.87175909
72MP0001666_abnormal_nutrient_absorption0.85592587
73MP0000358_abnormal_cell_content/0.85481066
74MP0003959_abnormal_lean_body0.84578259
75MP0005187_abnormal_penis_morphology0.83154330
76MP0009643_abnormal_urine_homeostasis0.82406843
77MP0001730_embryonic_growth_arrest0.81868800
78MP0009333_abnormal_splenocyte_physiolog0.81701360
79MP0005330_cardiomyopathy0.81018077
80MP0004215_abnormal_myocardial_fiber0.80925111
81MP0000609_abnormal_liver_physiology0.76473907
82MP0001119_abnormal_female_reproductive0.75092376
83MP0004036_abnormal_muscle_relaxation0.74981808
84MP0003950_abnormal_plasma_membrane0.74244537
85MP0001968_abnormal_touch/_nociception0.73017126
86MP0002080_prenatal_lethality0.69276607
87MP0003699_abnormal_female_reproductive0.68762861
88MP0000313_abnormal_cell_death0.67951148
89MP0001502_abnormal_circadian_rhythm0.67541959
90MP0001756_abnormal_urination0.66862444
91MP0009780_abnormal_chondrocyte_physiolo0.66662321
92MP0000538_abnormal_urinary_bladder0.66079526
93MP0004858_abnormal_nervous_system0.65775200
94MP0005408_hypopigmentation0.65157599
95MP0000598_abnormal_liver_morphology0.64490949
96MP0006138_congestive_heart_failure0.62692530
97MP0004272_abnormal_basement_membrane0.60098597
98MP0003137_abnormal_impulse_conducting0.59949847
99MP0001348_abnormal_lacrimal_gland0.58872049
100MP0004484_altered_response_of0.57470321

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)6.02791032
2Abnormal gallbladder physiology (HP:0012438)4.48236286
3Cholecystitis (HP:0001082)4.48236286
4Acute encephalopathy (HP:0006846)3.64707766
5Hyperthyroidism (HP:0000836)3.55410605
6Pendular nystagmus (HP:0012043)3.39289492
7J-shaped sella turcica (HP:0002680)3.34875865
8Cerebral edema (HP:0002181)3.15426795
9Prolonged partial thromboplastin time (HP:0003645)3.10406748
10Abnormality of serum amino acid levels (HP:0003112)3.00207164
11Hyperglycinuria (HP:0003108)2.95434669
12Abnormality of pyrimidine metabolism (HP:0004353)2.92152091
13Testicular atrophy (HP:0000029)2.83030356
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.82707543
15Homocystinuria (HP:0002156)2.76389135
16Abnormality of homocysteine metabolism (HP:0010919)2.76389135
17Hypobetalipoproteinemia (HP:0003563)2.74665796
18Hyperglycinemia (HP:0002154)2.69711552
19Truncus arteriosus (HP:0001660)2.68022475
20Acute necrotizing encephalopathy (HP:0006965)2.66132090
21Squamous cell carcinoma (HP:0002860)2.62549012
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62266444
23Proximal tubulopathy (HP:0000114)2.59793785
24Hyperammonemia (HP:0001987)2.57870015
25Hepatocellular carcinoma (HP:0001402)2.56763036
26Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.53188242
27Submucous cleft hard palate (HP:0000176)2.46666576
28Hypoplasia of the capital femoral epiphysis (HP:0003090)2.45502552
29Abnormal mitochondria in muscle tissue (HP:0008316)2.44876493
30Birth length less than 3rd percentile (HP:0003561)2.43099140
31Cholelithiasis (HP:0001081)2.42430007
32Reduced antithrombin III activity (HP:0001976)2.39203687
33Abnormality of methionine metabolism (HP:0010901)2.38964914
34Lethargy (HP:0001254)2.36044046
35Increased CSF lactate (HP:0002490)2.32122850
36Deep venous thrombosis (HP:0002625)2.31909451
37Abnormality of DNA repair (HP:0003254)2.31720921
38Entropion (HP:0000621)2.30408280
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25665041
40Abnormality of glycine metabolism (HP:0010895)2.25068779
41Abnormality of serine family amino acid metabolism (HP:0010894)2.25068779
42Upper limb muscle weakness (HP:0003484)2.23875008
43Hepatic necrosis (HP:0002605)2.23397133
44Amniotic constriction ring (HP:0009775)2.23051008
45Abnormality of placental membranes (HP:0011409)2.23051008
46Progressive macrocephaly (HP:0004481)2.23002116
47Abnormality of dental color (HP:0011073)2.22656474
48Glycosuria (HP:0003076)2.21618485
49Abnormality of urine glucose concentration (HP:0011016)2.21618485
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.18523521
51Seborrheic dermatitis (HP:0001051)2.18439683
52Epiphyseal stippling (HP:0010655)2.18243738
53Mitochondrial inheritance (HP:0001427)2.18146387
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18088730
55Abnormality of alanine metabolism (HP:0010916)2.18088730
56Hyperalaninemia (HP:0003348)2.18088730
57Abnormality of the renal collecting system (HP:0004742)2.11550413
58Abnormal gallbladder morphology (HP:0012437)2.11087455
59Poikiloderma (HP:0001029)2.10934920
60Chromsome breakage (HP:0040012)2.09365966
61Reticulocytosis (HP:0001923)2.08827994
62Abnormality of reticulocytes (HP:0004312)2.07757980
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05760626
64Reticulocytopenia (HP:0001896)2.05499061
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.05186656
66Cerebral palsy (HP:0100021)2.03782258
67Abnormality of the preputium (HP:0100587)2.00200129
68Hepatocellular necrosis (HP:0001404)1.99644210
69Abnormality of cochlea (HP:0000375)1.98322258
70Increased serum ferritin (HP:0003281)1.96820554
71Rough bone trabeculation (HP:0100670)1.96464120
72Small intestinal stenosis (HP:0012848)1.95223224
73Duodenal stenosis (HP:0100867)1.95223224
74Metabolic acidosis (HP:0001942)1.94933417
75Secondary amenorrhea (HP:0000869)1.94679944
76Intrahepatic cholestasis (HP:0001406)1.93830405
77Abnormal trabecular bone morphology (HP:0100671)1.90136820
78Abnormality of the carotid arteries (HP:0005344)1.89831426
79Hypoparathyroidism (HP:0000829)1.88045190
80Hyperbilirubinemia (HP:0002904)1.87689356
81Congenital stationary night blindness (HP:0007642)1.86593278
82Lactic acidosis (HP:0003128)1.86571069
83Myelodysplasia (HP:0002863)1.86541186
84Median cleft lip (HP:0000161)1.85535868
85Premature ovarian failure (HP:0008209)1.83135235
86Hypothermia (HP:0002045)1.82614813
87Abnormal epiphyseal ossification (HP:0010656)1.82421646
88Long clavicles (HP:0000890)1.80868032
89Morphological abnormality of the inner ear (HP:0011390)1.77650636
90Ankyloglossia (HP:0010296)1.77570769
91Abnormality of transition element cation homeostasis (HP:0011030)1.76782604
92Absent epiphyses (HP:0010577)1.76704104
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76704104
94Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74768927
95Popliteal pterygium (HP:0009756)1.73485277
96Duplicated collecting system (HP:0000081)1.71969546
97Abnormality of glycolysis (HP:0004366)1.71895167
98Increased serum lactate (HP:0002151)1.71700745
99Poor head control (HP:0002421)1.71310642
100Small hand (HP:0200055)1.69508365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.70202534
2EIF2AK15.11857743
3SIK34.83530135
4EIF2AK34.57778508
5BCR3.58597729
6BUB13.51583255
7STK392.77412618
8STK162.71281406
9PLK42.42763278
10MKNK22.17506981
11MST1R2.07129409
12ACVR1B2.06353646
13TLK11.90107096
14BRSK21.86404180
15MKNK11.78513029
16PDK21.78293185
17SRPK11.72728364
18WEE11.53812787
19OXSR11.53306103
20FRK1.49725925
21CCNB11.45308487
22NME21.44996141
23NEK11.44025252
24KSR11.39617814
25ERBB31.32446740
26PBK1.30498448
27EIF2AK21.28215356
28TTK1.21789456
29WNK41.21624110
30BRSK11.11569716
31CLK11.10646931
32NME11.05736483
33CDC71.01218130
34PLK10.86533297
35STK30.83003145
36PLK30.82732121
37AURKA0.82447759
38RPS6KB20.82437437
39MST40.82367048
40MUSK0.79220449
41RIPK40.77967965
42PLK20.77239409
43NUAK10.76028306
44NTRK30.75512264
45DDR20.73727899
46MAP3K30.68112219
47AURKB0.65832935
48RPS6KA50.63619812
49NEK20.63511149
50MAP3K20.62936132
51ADRBK20.61462799
52CSNK1A1L0.60696743
53CHEK20.60090948
54CSNK1G30.59488536
55TSSK60.58573000
56PTK60.57792916
57RAF10.56290475
58CDK70.55698853
59CHEK10.54321571
60MINK10.53912228
61MARK30.53782561
62CSNK2A10.51651952
63MET0.49821020
64BMPR20.49788443
65CSNK2A20.47362696
66PINK10.44971713
67PAK40.43163926
68GRK50.42399447
69VRK20.42172058
70ATR0.41227445
71CDK20.41183192
72PKN20.41083949
73CSNK1A10.41075421
74CDK10.40822132
75CSNK1G20.37595749
76ILK0.37412601
77ATM0.36278472
78MAPK150.35480809
79TNIK0.35151040
80MAP2K10.34989289
81LATS20.33916969
82ALK0.30160371
83WNK10.29890656
84CSNK1E0.29355200
85LRRK20.29261691
86CSNK1G10.27571695
87FER0.27246964
88PRKCG0.27221775
89PAK10.26998472
90TAOK30.25729869
91ERBB40.25246891
92PRKACG0.24604880
93KSR20.24176574
94MAP3K80.23828779
95STK100.23603718
96PRKACB0.22651161
97INSRR0.21658441
98AKT20.21509188
99PHKG10.20809287
100PHKG20.20809287

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.81147202
2One carbon pool by folate_Homo sapiens_hsa006702.72455639
3DNA replication_Homo sapiens_hsa030302.46117112
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.40398161
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36480107
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25292537
7Mismatch repair_Homo sapiens_hsa034302.21803971
8Arginine biosynthesis_Homo sapiens_hsa002202.19997435
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15037948
10Sulfur metabolism_Homo sapiens_hsa009202.04713789
11Propanoate metabolism_Homo sapiens_hsa006402.03647052
12Homologous recombination_Homo sapiens_hsa034402.02117689
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.01366512
14Retinol metabolism_Homo sapiens_hsa008301.96902354
15RNA transport_Homo sapiens_hsa030131.95705747
16Sulfur relay system_Homo sapiens_hsa041221.92565518
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.83085619
18Spliceosome_Homo sapiens_hsa030401.77989504
19Fanconi anemia pathway_Homo sapiens_hsa034601.73410872
20Selenocompound metabolism_Homo sapiens_hsa004501.72670380
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72591552
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69638965
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.68763328
24Basal transcription factors_Homo sapiens_hsa030221.66716359
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.66234653
26Nucleotide excision repair_Homo sapiens_hsa034201.65091476
27Ribosome_Homo sapiens_hsa030101.62953568
28RNA polymerase_Homo sapiens_hsa030201.58382727
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55600103
30Pyrimidine metabolism_Homo sapiens_hsa002401.55352995
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.53343286
32Biosynthesis of amino acids_Homo sapiens_hsa012301.44691872
33Carbon metabolism_Homo sapiens_hsa012001.43155031
34RNA degradation_Homo sapiens_hsa030181.33493236
35Chemical carcinogenesis_Homo sapiens_hsa052041.33100296
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30527716
37Fructose and mannose metabolism_Homo sapiens_hsa000511.29788601
38Pyruvate metabolism_Homo sapiens_hsa006201.29357454
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.25460261
40mRNA surveillance pathway_Homo sapiens_hsa030151.20862601
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20448788
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18834009
43Butanoate metabolism_Homo sapiens_hsa006501.16650650
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14122541
45Oxidative phosphorylation_Homo sapiens_hsa001901.12888840
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10331570
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09906924
48Base excision repair_Homo sapiens_hsa034101.07999775
49Tyrosine metabolism_Homo sapiens_hsa003501.05335791
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04496980
51Linoleic acid metabolism_Homo sapiens_hsa005911.04429424
52Parkinsons disease_Homo sapiens_hsa050121.01023378
53Other glycan degradation_Homo sapiens_hsa005110.98067012
54Phenylalanine metabolism_Homo sapiens_hsa003600.91711250
55Complement and coagulation cascades_Homo sapiens_hsa046100.90787092
56Phototransduction_Homo sapiens_hsa047440.87177771
57Asthma_Homo sapiens_hsa053100.86382866
58Glutathione metabolism_Homo sapiens_hsa004800.83956407
59Non-homologous end-joining_Homo sapiens_hsa034500.82784392
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82600196
61Metabolic pathways_Homo sapiens_hsa011000.82131546
62Cell cycle_Homo sapiens_hsa041100.81775170
63beta-Alanine metabolism_Homo sapiens_hsa004100.81610742
64Starch and sucrose metabolism_Homo sapiens_hsa005000.78950907
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78322926
66Renin-angiotensin system_Homo sapiens_hsa046140.76196002
67Pentose phosphate pathway_Homo sapiens_hsa000300.75891351
68Fatty acid metabolism_Homo sapiens_hsa012120.75022733
69Protein export_Homo sapiens_hsa030600.74867595
70Fatty acid elongation_Homo sapiens_hsa000620.72950626
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72890464
72Purine metabolism_Homo sapiens_hsa002300.71763805
73Vitamin B6 metabolism_Homo sapiens_hsa007500.69810802
74Peroxisome_Homo sapiens_hsa041460.64132115
75Folate biosynthesis_Homo sapiens_hsa007900.64050138
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.60486324
77Huntingtons disease_Homo sapiens_hsa050160.59171454
78Arginine and proline metabolism_Homo sapiens_hsa003300.58296337
79Taste transduction_Homo sapiens_hsa047420.57626404
80Oocyte meiosis_Homo sapiens_hsa041140.55765401
81Caffeine metabolism_Homo sapiens_hsa002320.54781654
82Fatty acid degradation_Homo sapiens_hsa000710.54659162
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54490502
84Alzheimers disease_Homo sapiens_hsa050100.51249105
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50781134
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.50604758
87Bile secretion_Homo sapiens_hsa049760.48464819
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.47901930
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47438575
90Arachidonic acid metabolism_Homo sapiens_hsa005900.43124516
91p53 signaling pathway_Homo sapiens_hsa041150.37893352
92Tryptophan metabolism_Homo sapiens_hsa003800.37568822
93Sphingolipid metabolism_Homo sapiens_hsa006000.36932585
94N-Glycan biosynthesis_Homo sapiens_hsa005100.36566220
95Vitamin digestion and absorption_Homo sapiens_hsa049770.32623354
96Lysine degradation_Homo sapiens_hsa003100.31449051
97ABC transporters_Homo sapiens_hsa020100.31231927
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30414975
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30079836
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25577420

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