CRYGA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytolysis (GO:0019835)8.42938078
2* visual perception (GO:0007601)8.34906130
3camera-type eye development (GO:0043010)8.30090260
4* sensory perception of light stimulus (GO:0050953)8.24887821
5histone H3-K9 demethylation (GO:0033169)7.80554075
6muscle cell cellular homeostasis (GO:0046716)7.72133966
7protein refolding (GO:0042026)7.70089535
8bile acid and bile salt transport (GO:0015721)7.01295044
9cellular response to osmotic stress (GO:0071470)6.96009045
10regulation of protein sumoylation (GO:0033233)6.92963984
11eye development (GO:0001654)6.68322238
12myofibril assembly (GO:0030239)6.34246893
13positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)5.17976188
14sensory organ development (GO:0007423)5.11620180
15response to salt stress (GO:0009651)4.92634096
16negative regulation of homotypic cell-cell adhesion (GO:0034111)4.74468504
17insulin-like growth factor receptor signaling pathway (GO:0048009)4.70116413
18sarcomere organization (GO:0045214)4.64578946
19regulation of myoblast differentiation (GO:0045661)4.09744067
20* lens development in camera-type eye (GO:0002088)33.7702650
21protein homotrimerization (GO:0070207)3.88769096
22* sensory perception (GO:0007600)3.82671641
23positive regulation of dendritic spine morphogenesis (GO:0061003)3.76372885
24lung epithelium development (GO:0060428)3.64153659
25regulation of Rac protein signal transduction (GO:0035020)3.48745449
26water transport (GO:0006833)3.43420544
27regulation of platelet aggregation (GO:0090330)3.37475806
28positive regulation of wound healing (GO:0090303)3.27033392
29positive regulation of calcium ion transport into cytosol (GO:0010524)3.25297034
30regulation of skeletal muscle fiber development (GO:0048742)3.18041341
31intermediate filament cytoskeleton organization (GO:0045104)3.05101265
32cellular response to calcium ion (GO:0071277)3.01129253
33lens fiber cell development (GO:0070307)27.4682589
34lens fiber cell differentiation (GO:0070306)21.6093695
35fluid transport (GO:0042044)2.95719179
36intermediate filament-based process (GO:0045103)2.93638878
37response to activity (GO:0014823)2.74853662
38histone lysine demethylation (GO:0070076)2.74046405
39respiratory tube development (GO:0030323)2.72414433
40dopaminergic neuron differentiation (GO:0071542)2.71727890
41cerebellar granule cell differentiation (GO:0021707)2.71373543
42negative regulation of platelet activation (GO:0010544)2.65718888
43skeletal muscle organ development (GO:0060538)2.59576699
44activation of JUN kinase activity (GO:0007257)2.56400447
45lung-associated mesenchyme development (GO:0060484)2.56064200
46mating behavior (GO:0007617)2.55685892
47histone demethylation (GO:0016577)2.55474557
48epithelial cell development (GO:0002064)2.53612939
49actomyosin structure organization (GO:0031032)2.48219690
50L-alpha-amino acid transmembrane transport (GO:1902475)2.47401291
51negative regulation of cell size (GO:0045792)2.42113276
52regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.39807524
53regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.39373789
54regulation of myotube differentiation (GO:0010830)2.36149823
55diaphragm development (GO:0060539)2.30218342
56response to osmotic stress (GO:0006970)2.28735902
57protein dealkylation (GO:0008214)2.25044874
58protein demethylation (GO:0006482)2.25044874
59basement membrane organization (GO:0071711)2.23325608
60cell-cell junction assembly (GO:0007043)2.22182347
61prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.19205136
62positive regulation of dendritic spine development (GO:0060999)2.18090906
63positive regulation of dendrite morphogenesis (GO:0050775)2.13518840
64protein localization to cell surface (GO:0034394)2.12597202
65regulation of homotypic cell-cell adhesion (GO:0034110)2.12154198
66metanephric nephron tubule development (GO:0072234)2.09604048
67metanephric tubule development (GO:0072170)2.09604048
68protein trimerization (GO:0070206)2.04647165
69neuronal stem cell maintenance (GO:0097150)2.03213137
70carnitine shuttle (GO:0006853)2.00312986
71lens morphogenesis in camera-type eye (GO:0002089)11.0389961
72response to muscle activity (GO:0014850)10.4746236
73collecting duct development (GO:0072044)1.99459851
74apoptotic process involved in morphogenesis (GO:0060561)1.97883107
75negative regulation of hormone biosynthetic process (GO:0032353)1.97524097
76negative regulation of hormone metabolic process (GO:0032351)1.97524097
77positive regulation of developmental growth (GO:0048639)1.96882240
78dorsal/ventral axis specification (GO:0009950)1.96008869
79apoptotic process involved in development (GO:1902742)1.95126337
80negative regulation of potassium ion transmembrane transport (GO:1901380)1.92354036
81cytoskeletal anchoring at plasma membrane (GO:0007016)1.92013454
82metanephric nephron epithelium development (GO:0072243)1.90769952
83regulation of dendritic spine morphogenesis (GO:0061001)1.89401459
84cellular response to vitamin D (GO:0071305)1.88495841
85negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.85913274
86cell maturation (GO:0048469)1.85571176
87negative regulation of JUN kinase activity (GO:0043508)1.84130186
88anatomical structure regression (GO:0060033)1.81162782
89cellular response to prostaglandin stimulus (GO:0071379)1.80406793
90fatty acid transmembrane transport (GO:1902001)1.76443604
91cartilage morphogenesis (GO:0060536)1.75784451
92regulation of skeletal muscle tissue development (GO:0048641)1.72593196
93bone trabecula formation (GO:0060346)1.71956823
94regulation of calcium ion transport into cytosol (GO:0010522)1.71304999
95regulation of striated muscle cell differentiation (GO:0051153)1.71030030
96lung morphogenesis (GO:0060425)1.66679836
97planar cell polarity pathway involved in neural tube closure (GO:0090179)1.66447245
98metanephric epithelium development (GO:0072207)1.65103877
99regulation of wound healing (GO:0061041)1.64597294
100regulation of bile acid biosynthetic process (GO:0070857)1.64566838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.53274348
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human5.26541226
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.03510622
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.38858444
5SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66629908
6BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.57170722
7EZH2_22144423_ChIP-Seq_EOC_Human2.14948027
8* PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05108309
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03565472
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.03294759
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00217245
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00217245
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse10.6344867
14NANOG_16153702_ChIP-ChIP_HESCs_Human1.99565954
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.99259800
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93767899
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90524484
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.72196663
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69053913
20NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.64370253
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62885978
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.57940002
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57600398
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57017290
25SOX2_22085726_ChIP-Seq_NPCs_Mouse1.51184985
26GATA1_22025678_ChIP-Seq_K562_Human1.49804548
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49727735
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45654653
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.42328075
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39746199
31* GATA3_24758297_ChIP-Seq_MCF-7_Human1.38774928
32* NFE2_27457419_Chip-Seq_LIVER_Mouse1.35556332
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34430677
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33875703
35JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31826663
36JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31281118
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.29854457
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29628451
39CTCF_27219007_Chip-Seq_Bcells_Human1.29521655
40TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27844926
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.27601873
42TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27348922
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.26000207
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25334442
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24766121
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.24687471
47SALL4_22934838_ChIP-ChIP_CD34+_Human1.22888609
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22669475
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19906415
50GATA1_19941827_ChIP-Seq_MEL86_Mouse1.19886058
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19746810
52LXR_22292898_ChIP-Seq_THP-1_Human1.18044936
53ZNF263_19887448_ChIP-Seq_K562_Human1.17959124
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.14618606
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13468967
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13215066
57VDR_22108803_ChIP-Seq_LS180_Human1.12307285
58SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11486237
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.11051260
60* CTCF_18555785_Chip-Seq_ESCs_Mouse1.10229838
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.08646491
62* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08250539
63TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08009133
64* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07572225
65* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05215031
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04543207
67* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04421311
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02893622
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.01796398
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.01103302
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00554532
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00276224
73ZNF274_21170338_ChIP-Seq_K562_Hela0.99950177
74CLOCK_20551151_ChIP-Seq_293T_Human0.99380513
75NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97713609
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97327939
77SMAD3_21741376_ChIP-Seq_ESCs_Human0.95696496
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95673258
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95337655
80MYC_18940864_ChIP-ChIP_HL60_Human0.91744692
81KDM2B_26808549_Chip-Seq_K562_Human0.89982488
82SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88044369
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87821602
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86955599
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85892381
86SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85856077
87* PU1_27457419_Chip-Seq_LIVER_Mouse0.85791579
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84198235
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83996228
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83600159
91OCT4_19829295_ChIP-Seq_ESCs_Human0.83411151
92SOX2_18555785_Chip-Seq_ESCs_Mouse0.83267467
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82709226
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81570352
95TCF7_22412390_ChIP-Seq_EML_Mouse0.81172869
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81086130
97IGF1R_20145208_ChIP-Seq_DFB_Human0.80559769
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.79870716
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78740461
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77803564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005193_abnormal_anterior_eye9.06228754
2MP0005253_abnormal_eye_physiology4.88515303
3MP0001286_abnormal_eye_development4.00292914
4MP0002092_abnormal_eye_morphology3.92130289
5MP0000749_muscle_degeneration3.86950043
6MP0005197_abnormal_uvea_morphology3.86800260
7MP0003941_abnormal_skin_development3.50666898
8MP0005391_vision/eye_phenotype3.18206750
9MP0002090_abnormal_vision2.39961217
10MP0001346_abnormal_lacrimal_gland2.28018049
11* MP0002697_abnormal_eye_size13.7132127
12MP0002108_abnormal_muscle_morphology1.73612750
13MP0004272_abnormal_basement_membrane1.69344897
14MP0002269_muscular_atrophy1.57747225
15MP0005330_cardiomyopathy1.56829939
16MP0002638_abnormal_pupillary_reflex1.38601059
17MP0010368_abnormal_lymphatic_system1.36637686
18MP0002139_abnormal_hepatobiliary_system1.21238986
19MP0001299_abnormal_eye_distance/1.13427922
20MP0002735_abnormal_chemical_nociception1.09968893
21MP0005195_abnormal_posterior_eye1.03413963
22MP0003705_abnormal_hypodermis_morpholog1.02127379
23MP0001340_abnormal_eyelid_morphology0.93858748
24MP0005319_abnormal_enzyme/_coenzyme0.80967371
25MP0004087_abnormal_muscle_fiber0.79554716
26MP0003123_paternal_imprinting0.76721724
27MP0004859_abnormal_synaptic_plasticity0.75485760
28MP0005369_muscle_phenotype0.70270849
29MP0000049_abnormal_middle_ear0.68046921
30MP0003252_abnormal_bile_duct0.64777766
31MP0009053_abnormal_anal_canal0.64578582
32MP0000759_abnormal_skeletal_muscle0.62938149
33MP0000537_abnormal_urethra_morphology0.59292495
34MP0001905_abnormal_dopamine_level0.57744079
35MP0005551_abnormal_eye_electrophysiolog0.53724016
36MP0005187_abnormal_penis_morphology0.53689038
37MP0005085_abnormal_gallbladder_physiolo0.53621927
38MP0002736_abnormal_nociception_after0.50744224
39MP0002734_abnormal_mechanical_nocicepti0.49495456
40MP0005360_urolithiasis0.49179588
41MP0009780_abnormal_chondrocyte_physiolo0.47461163
42MP0003566_abnormal_cell_adhesion0.45825989
43MP0003787_abnormal_imprinting0.45456089
44MP0003656_abnormal_erythrocyte_physiolo0.44953252
45MP0002249_abnormal_larynx_morphology0.44180206
46MP0002089_abnormal_postnatal_growth/wei0.43339074
47MP0001915_intracranial_hemorrhage0.43131409
48MP0000747_muscle_weakness0.42314746
49MP0004885_abnormal_endolymph0.42149973
50MP0003635_abnormal_synaptic_transmissio0.41979575
51MP0001968_abnormal_touch/_nociception0.41909529
52MP0003329_amyloid_beta_deposits0.41425520
53MP0000751_myopathy0.41190479
54MP0006292_abnormal_olfactory_placode0.41110917
55MP0003115_abnormal_respiratory_system0.38535432
56MP0003942_abnormal_urinary_system0.38057210
57MP0001879_abnormal_lymphatic_vessel0.37243800
58MP0002177_abnormal_outer_ear0.35300051
59MP0001958_emphysema0.35080948
60MP0009250_abnormal_appendicular_skeleto0.34003497
61MP0000428_abnormal_craniofacial_morphol0.33990437
62MP0010234_abnormal_vibrissa_follicle0.33607421
63MP0005248_abnormal_Harderian_gland0.32842467
64MP0001943_abnormal_respiration0.31656082
65MP0004134_abnormal_chest_morphology0.31579269
66MP0002063_abnormal_learning/memory/cond0.31343245
67MP0005623_abnormal_meninges_morphology0.30642059
68MP0002653_abnormal_ependyma_morphology0.30524405
69MP0008438_abnormal_cutaneous_collagen0.30161324
70MP0004197_abnormal_fetal_growth/weight/0.30136925
71MP0002295_abnormal_pulmonary_circulatio0.28946228
72MP0002925_abnormal_cardiovascular_devel0.28928749
73MP0004270_analgesia0.28894827
74MP0004811_abnormal_neuron_physiology0.28798448
75MP0004858_abnormal_nervous_system0.28735479
76MP0002733_abnormal_thermal_nociception0.28380949
77MP0003959_abnormal_lean_body0.28063882
78MP0005647_abnormal_sex_gland0.26797935
79MP0000955_abnormal_spinal_cord0.26353611
80MP0005257_abnormal_intraocular_pressure0.26129393
81MP0004084_abnormal_cardiac_muscle0.23674173
82MP0001784_abnormal_fluid_regulation0.23081751
83MP0002106_abnormal_muscle_physiology0.22981777
84MP0001614_abnormal_blood_vessel0.22758316
85MP0002152_abnormal_brain_morphology0.22733831
86MP0003122_maternal_imprinting0.20840524
87MP0002128_abnormal_blood_circulation0.20056230
88MP0000266_abnormal_heart_morphology0.19627683
89MP0002064_seizures0.19103188
90MP0002163_abnormal_gland_morphology0.18999513
91MP0003119_abnormal_digestive_system0.18978332
92MP0000604_amyloidosis0.18437648
93MP0008770_decreased_survivor_rate0.17697239
94MP0001765_abnormal_ion_homeostasis0.17536093
95MP0010329_abnormal_lipoprotein_level0.17301730
96MP0005365_abnormal_bile_salt0.16624557
97MP0004145_abnormal_muscle_electrophysio0.15964036
98MP0004185_abnormal_adipocyte_glucose0.15749267
99MP0004233_abnormal_muscle_weight0.15681448
100MP0002081_perinatal_lethality0.15661209

Predicted human phenotypes

RankGene SetZ-score
1Congenital cataract (HP:0000519)7.94523974
2Corneal dystrophy (HP:0001131)7.10718287
3Amblyopia (HP:0000646)6.96547423
4Anterior segment dysgenesis (HP:0007700)5.96383533
5Polar cataract (HP:0010696)4.35275774
6Clumsiness (HP:0002312)3.95212990
7Microcornea (HP:0000482)3.56951851
8Nuclear cataract (HP:0100018)27.5842466
9Zonular cataract (HP:0010920)24.3176978
10Iris coloboma (HP:0000612)2.86026994
11Eosinophilia (HP:0001880)2.85799277
12Opacification of the corneal stroma (HP:0007759)2.58669177
13Abnormality of the anterior chamber (HP:0000593)2.53746488
14Granulocytopenia (HP:0001913)2.27959273
15Sclerocornea (HP:0000647)2.25466870
16Scapular winging (HP:0003691)2.11229191
17Proximal amyotrophy (HP:0007126)2.09223457
18Congenital primary aphakia (HP:0007707)2.04846709
19Abnormality of eosinophils (HP:0001879)1.94262170
20Aplasia/Hypoplasia of the lens (HP:0008063)1.75098067
21Posterior subcapsular cataract (HP:0007787)1.74412100
22Neonatal respiratory distress (HP:0002643)1.64783350
23Fetal akinesia sequence (HP:0001989)1.57077572
24Aplasia/Hypoplasia of the macula (HP:0008059)1.53103644
25Popliteal pterygium (HP:0009756)1.50217128
26Long clavicles (HP:0000890)1.48899715
27Aplasia of the musculature (HP:0100854)1.46657059
28Aplasia/Hypoplasia affecting the retina (HP:0008061)1.45766607
29Amniotic constriction ring (HP:0009775)1.37237793
30Abnormality of placental membranes (HP:0011409)1.37237793
31Akinesia (HP:0002304)1.33847880
32Hypoplastic nipples (HP:0002557)1.28805450
33Difficulty walking (HP:0002355)1.28640050
34Abnormality of the shoulder girdle musculature (HP:0001435)1.27714919
35Leukocytosis (HP:0001974)1.27518023
36Rib fusion (HP:0000902)1.12639387
37Fused cervical vertebrae (HP:0002949)1.09129114
38Symphalangism affecting the phalanges of the hand (HP:0009773)1.02115530
39Vertebral clefting (HP:0008428)0.99898229
40Abnormality of the labia majora (HP:0012881)0.95309392
41Subcapsular cataract (HP:0000523)0.92342108
42Aplasia/Hypoplasia involving the musculature (HP:0001460)0.85641984
43Exostoses (HP:0100777)0.81834280
44Pterygium (HP:0001059)0.78261876
45Chorioretinal coloboma (HP:0000567)0.77420722
46Camptodactyly of toe (HP:0001836)0.72378961
47Lymphangioma (HP:0100764)0.72350320
48Malignant hyperthermia (HP:0002047)0.71966856
49Thin ribs (HP:0000883)0.69710713
50Ependymoma (HP:0002888)0.68598042
51Hypoplastic heart (HP:0001961)0.68452764
52Neoplasm of the heart (HP:0100544)0.66959983
53Abnormal number of incisors (HP:0011064)0.64814844
54Diminished movement (HP:0002374)0.57814349
55Aplasia/Hypoplasia of the nipples (HP:0006709)0.57420584
56Dislocated radial head (HP:0003083)0.55598957
57Cystic hygroma (HP:0000476)0.55505375
58Severe visual impairment (HP:0001141)0.54011956
59Abnormality of the humeroradial joint (HP:0100744)0.53452845
60Pointed chin (HP:0000307)0.52979598
61Muscle fiber splitting (HP:0003555)0.52466767
62Enlarged kidneys (HP:0000105)0.52292438
63Split foot (HP:0001839)0.51989209
64Abnormality of the radial head (HP:0003995)0.51351110
65Hepatoblastoma (HP:0002884)0.50036908
66Hypoplastic pelvis (HP:0008839)0.49832188
67Flexion contracture of toe (HP:0005830)0.49588528
68Joint contractures involving the joints of the feet (HP:0100492)0.49588528
69Astrocytoma (HP:0009592)0.49313718
70Abnormality of the astrocytes (HP:0100707)0.49313718
71Autosomal dominant inheritance (HP:0000006)0.49216799
72Visceral angiomatosis (HP:0100761)0.48210308
73Annular pancreas (HP:0001734)0.47269429
74Skin nodule (HP:0200036)0.46858414
75Hyporeflexia of lower limbs (HP:0002600)0.46667580
76Hamartoma of the eye (HP:0010568)0.45976752
77Abnormality of cochlea (HP:0000375)0.45954574
78Neonatal hypoglycemia (HP:0001998)0.44576558
79Buphthalmos (HP:0000557)0.44467177
80Patellar aplasia (HP:0006443)0.44286544
81Hemangiomatosis (HP:0007461)0.43682195
82Hemiplegia (HP:0002301)0.43237312
83Abnormality of the labia (HP:0000058)0.42809036
84Broad nasal tip (HP:0000455)0.42580211
85Deep venous thrombosis (HP:0002625)0.41441235
86Exercise-induced muscle cramps (HP:0003710)0.39984375
87Humeroradial synostosis (HP:0003041)0.39540430
88Synostosis involving the elbow (HP:0003938)0.39540430
89Exercise-induced myalgia (HP:0003738)0.39282032
90Aplasia/Hypoplasia affecting the fundus (HP:0008057)0.39050829
91Aplasia/Hypoplasia of the patella (HP:0006498)0.38847590
92Adenoma sebaceum (HP:0009720)0.38422019
93Angiofibromas (HP:0010615)0.38422019
94Abnormal pancreas size (HP:0012094)0.38151137
95Abnormalities of placenta or umbilical cord (HP:0001194)0.36443973
96Hyperthyroidism (HP:0000836)0.36242769
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)0.36108769
98Overgrowth (HP:0001548)0.36000821
99Hypopigmentation of the fundus (HP:0007894)0.34991844
100Vertebral fusion (HP:0002948)0.34363017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K68.35915746
2BLK4.93731608
3SGK14.21009584
4STK393.15697571
5WNK42.99409677
6MST42.84558093
7NTRK12.79604985
8FLT32.78404200
9PRKG12.60834265
10PKN22.36515743
11SIK12.29729180
12TRIB32.15127483
13MET1.83082403
14PDGFRA1.72965437
15IGF1R1.71761482
16LRRK21.71085959
17PRKCB1.64305026
18INSR1.49673846
19MAPK101.48897588
20EPHB21.38835727
21PNCK1.37031153
22PRKACB1.19847472
23ZAP701.18293204
24ERBB21.15553349
25CDK61.14355243
26EPHA41.14076505
27STK101.13668394
28PTK61.12570913
29WNK11.12164773
30ICK1.11531269
31PAK41.08727949
32RPS6KA31.04837441
33MAP3K101.04644272
34SCYL20.89711045
35PRKCQ0.89088447
36PTK20.88042830
37ROCK20.87728699
38PAK60.81561693
39PKN10.76168508
40ILK0.76003872
41CAMKK10.75697459
42PRKACG0.74895578
43PHKG10.73949839
44PHKG20.73949839
45CSF1R0.71676053
46PAK30.70251013
47EPHA20.67649566
48LATS10.63171321
49CAMK1G0.62500173
50LATS20.62388297
51SGK2230.59892006
52SGK4940.59892006
53MINK10.55323552
54ROCK10.55173460
55FGFR10.53612723
56MAPKAPK50.51953181
57RPS6KA20.51782376
58CSNK2A20.48926804
59UHMK10.44766505
60CDK50.41204559
61NTRK30.40456968
62PTK2B0.40412258
63ALK0.39830441
64EGFR0.38385009
65ADRBK10.35154866
66PAK20.35080930
67PDGFRB0.33744510
68RPS6KA10.33726317
69KSR10.32849030
70NEK90.32824235
71PRKCH0.32427888
72FER0.31817486
73TTN0.30159060
74CSNK1E0.29018857
75KSR20.28332634
76JAK30.27926533
77MAP3K80.27314300
78HIPK20.25518066
79MAP3K90.24752014
80MARK10.24747209
81RPS6KL10.24731322
82RPS6KC10.24731322
83CDK140.23393512
84TBK10.22212519
85FYN0.22192274
86MKNK10.21974891
87DYRK20.21703818
88BMX0.21691921
89PRKCA0.20766128
90FGR0.19447028
91MAPKAPK20.19054488
92CSNK1A1L0.17839298
93AKT20.17083192
94DMPK0.16840658
95SRC0.16328531
96FGFR20.16207988
97DAPK20.16133037
98LIMK10.16093831
99CDK40.15916401
100CDK150.15654236

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.43901160
2Small cell lung cancer_Homo sapiens_hsa052222.42074732
3Nitrogen metabolism_Homo sapiens_hsa009102.10418852
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04921855
5Hedgehog signaling pathway_Homo sapiens_hsa043402.02847061
6Central carbon metabolism in cancer_Homo sapiens_hsa052301.95438865
7Primary bile acid biosynthesis_Homo sapiens_hsa001201.91463820
8Basal cell carcinoma_Homo sapiens_hsa052171.87383613
9Adherens junction_Homo sapiens_hsa045201.75605491
10Melanogenesis_Homo sapiens_hsa049161.62880003
11Arginine biosynthesis_Homo sapiens_hsa002201.62131529
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61928612
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55835841
14mTOR signaling pathway_Homo sapiens_hsa041501.53697098
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52194292
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47454024
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42838217
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40982720
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37093581
20ECM-receptor interaction_Homo sapiens_hsa045121.32576119
21Proteoglycans in cancer_Homo sapiens_hsa052051.27843937
22Circadian entrainment_Homo sapiens_hsa047131.27825068
23Insulin signaling pathway_Homo sapiens_hsa049101.26007366
24Fatty acid degradation_Homo sapiens_hsa000711.25772326
25Amoebiasis_Homo sapiens_hsa051461.24305671
26Glioma_Homo sapiens_hsa052141.22663779
27Biosynthesis of amino acids_Homo sapiens_hsa012301.20046307
28GABAergic synapse_Homo sapiens_hsa047271.14390551
29Dorso-ventral axis formation_Homo sapiens_hsa043201.13532361
30Olfactory transduction_Homo sapiens_hsa047401.13482653
31Bile secretion_Homo sapiens_hsa049761.13475579
32Wnt signaling pathway_Homo sapiens_hsa043101.13124440
33Glucagon signaling pathway_Homo sapiens_hsa049221.12084348
34Synaptic vesicle cycle_Homo sapiens_hsa047211.11523939
35Long-term potentiation_Homo sapiens_hsa047201.11028650
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06438902
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03448570
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03207805
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.01967421
40Protein digestion and absorption_Homo sapiens_hsa049741.00058967
41Focal adhesion_Homo sapiens_hsa045100.97962575
42Axon guidance_Homo sapiens_hsa043600.97442280
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95936862
44Sulfur metabolism_Homo sapiens_hsa009200.94314779
45Hippo signaling pathway_Homo sapiens_hsa043900.93988214
46Tight junction_Homo sapiens_hsa045300.92304948
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92002588
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.91023826
49Renal cell carcinoma_Homo sapiens_hsa052110.90901337
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90892542
51Gap junction_Homo sapiens_hsa045400.90800641
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88192027
53Type II diabetes mellitus_Homo sapiens_hsa049300.87811040
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87789866
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87574468
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86101262
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85595299
58Butanoate metabolism_Homo sapiens_hsa006500.85323095
59Arginine and proline metabolism_Homo sapiens_hsa003300.83441481
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.83432243
61Fatty acid metabolism_Homo sapiens_hsa012120.82244540
62Pathways in cancer_Homo sapiens_hsa052000.79949156
63Vibrio cholerae infection_Homo sapiens_hsa051100.78747864
64Insulin resistance_Homo sapiens_hsa049310.77120912
65Gastric acid secretion_Homo sapiens_hsa049710.76090266
66Estrogen signaling pathway_Homo sapiens_hsa049150.75305741
67Cholinergic synapse_Homo sapiens_hsa047250.74645592
68Glutamatergic synapse_Homo sapiens_hsa047240.73551273
69Prion diseases_Homo sapiens_hsa050200.73411541
70Dopaminergic synapse_Homo sapiens_hsa047280.72771201
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72700073
72Carbon metabolism_Homo sapiens_hsa012000.72363945
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72152246
74Tryptophan metabolism_Homo sapiens_hsa003800.72142772
75Insulin secretion_Homo sapiens_hsa049110.71220515
76Chronic myeloid leukemia_Homo sapiens_hsa052200.64938900
77Thyroid cancer_Homo sapiens_hsa052160.64338983
78ErbB signaling pathway_Homo sapiens_hsa040120.63291345
79PPAR signaling pathway_Homo sapiens_hsa033200.62475460
80Complement and coagulation cascades_Homo sapiens_hsa046100.61441152
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60604444
82Starch and sucrose metabolism_Homo sapiens_hsa005000.60147684
83Long-term depression_Homo sapiens_hsa047300.59747396
84Oxytocin signaling pathway_Homo sapiens_hsa049210.59556103
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.59426182
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59167544
87Glutathione metabolism_Homo sapiens_hsa004800.58192198
88Rap1 signaling pathway_Homo sapiens_hsa040150.57162735
89Amphetamine addiction_Homo sapiens_hsa050310.56832633
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56418866
91AMPK signaling pathway_Homo sapiens_hsa041520.56226441
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56135922
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.55708203
94Dilated cardiomyopathy_Homo sapiens_hsa054140.55368806
95Toxoplasmosis_Homo sapiens_hsa051450.54319020
96MicroRNAs in cancer_Homo sapiens_hsa052060.54056959
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53421557
98Bladder cancer_Homo sapiens_hsa052190.52591087
99Cocaine addiction_Homo sapiens_hsa050300.46334831
100Morphine addiction_Homo sapiens_hsa050320.45814540

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »