CROCCP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26357656
2protein-cofactor linkage (GO:0018065)3.89596029
3meiotic chromosome segregation (GO:0045132)3.87781932
4nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.75686644
5exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.73960720
6ATP synthesis coupled proton transport (GO:0015986)3.66143246
7energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66143246
8spliceosomal snRNP assembly (GO:0000387)3.65394900
9DNA damage response, detection of DNA damage (GO:0042769)3.58355522
10DNA integration (GO:0015074)3.55868310
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54298094
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.54298094
13NADH dehydrogenase complex assembly (GO:0010257)3.54298094
14mismatch repair (GO:0006298)3.53003955
15behavioral response to nicotine (GO:0035095)3.50199621
16mitochondrial respiratory chain complex assembly (GO:0033108)3.48026301
17rRNA modification (GO:0000154)3.43654626
18peptidyl-arginine methylation (GO:0018216)3.38111053
19peptidyl-arginine N-methylation (GO:0035246)3.38111053
20positive regulation of mitochondrial fission (GO:0090141)3.34556052
21protein localization to cilium (GO:0061512)3.31728213
22mitochondrial RNA metabolic process (GO:0000959)3.30954153
23peptidyl-arginine omega-N-methylation (GO:0035247)3.30724060
24somite development (GO:0061053)3.30720721
25DNA deamination (GO:0045006)3.28496443
26reciprocal meiotic recombination (GO:0007131)3.23699286
27reciprocal DNA recombination (GO:0035825)3.23699286
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.17009354
29base-excision repair, AP site formation (GO:0006285)3.16928405
30protein complex biogenesis (GO:0070271)3.13021115
31nonmotile primary cilium assembly (GO:0035058)3.12544744
32protein polyglutamylation (GO:0018095)3.12175318
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11379392
34pyrimidine nucleobase catabolic process (GO:0006208)3.10698743
35chromatin remodeling at centromere (GO:0031055)3.08791362
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07375791
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07375791
38intraciliary transport (GO:0042073)3.02424300
39preassembly of GPI anchor in ER membrane (GO:0016254)3.01457088
40C-terminal protein lipidation (GO:0006501)3.01293990
41protein neddylation (GO:0045116)3.00054606
42sequestering of actin monomers (GO:0042989)2.98988770
43positive regulation of prostaglandin secretion (GO:0032308)2.95326019
44adenosine metabolic process (GO:0046085)2.94375830
45DNA topological change (GO:0006265)2.92397282
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91374344
47regulation of mitotic spindle checkpoint (GO:1903504)2.91374344
48gamma-aminobutyric acid transport (GO:0015812)2.91365890
49cullin deneddylation (GO:0010388)2.90560325
50purine nucleobase biosynthetic process (GO:0009113)2.89162888
51nucleobase biosynthetic process (GO:0046112)2.86776174
52regulation of mitochondrial translation (GO:0070129)2.84710858
53C-terminal protein amino acid modification (GO:0018410)2.83090844
54chaperone-mediated protein transport (GO:0072321)2.82904923
55regulation of helicase activity (GO:0051095)2.82045265
56retinal ganglion cell axon guidance (GO:0031290)2.77722721
57proteasome assembly (GO:0043248)2.77278158
58respiratory electron transport chain (GO:0022904)2.76667214
59histone arginine methylation (GO:0034969)2.73925042
60purine deoxyribonucleotide catabolic process (GO:0009155)2.72306336
61electron transport chain (GO:0022900)2.71062773
62translesion synthesis (GO:0019985)2.70780652
63fucose catabolic process (GO:0019317)2.70408844
64L-fucose metabolic process (GO:0042354)2.70408844
65L-fucose catabolic process (GO:0042355)2.70408844
66rRNA methylation (GO:0031167)2.70014849
67maturation of 5.8S rRNA (GO:0000460)2.69547025
68oxidative phosphorylation (GO:0006119)2.69302813
69photoreceptor cell maintenance (GO:0045494)2.67962378
70CENP-A containing nucleosome assembly (GO:0034080)2.66846758
71iron-sulfur cluster assembly (GO:0016226)2.66844301
72metallo-sulfur cluster assembly (GO:0031163)2.66844301
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.65963626
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.65963626
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65056958
76platelet dense granule organization (GO:0060155)2.64067521
77pseudouridine synthesis (GO:0001522)2.63474816
78water-soluble vitamin biosynthetic process (GO:0042364)2.63434645
79snRNA processing (GO:0016180)2.63036900
80microtubule severing (GO:0051013)2.62602237
81termination of RNA polymerase III transcription (GO:0006386)2.61981381
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.61981381
83neural tube formation (GO:0001841)2.61261040
84DNA replication checkpoint (GO:0000076)2.60679548
85cilium morphogenesis (GO:0060271)2.60165802
86histone mRNA metabolic process (GO:0008334)2.59510476
87GPI anchor metabolic process (GO:0006505)2.58433300
88spliceosomal complex assembly (GO:0000245)2.56624501
89peptidyl-histidine modification (GO:0018202)2.54763978
90deoxyribonucleotide catabolic process (GO:0009264)2.53870715
91presynaptic membrane assembly (GO:0097105)2.53240826
92protein K11-linked deubiquitination (GO:0035871)2.49771945
93protein K6-linked ubiquitination (GO:0085020)2.49106130
94transcription from mitochondrial promoter (GO:0006390)2.47939331
95DNA double-strand break processing (GO:0000729)2.47586894
96tRNA processing (GO:0008033)2.46340443
97ubiquinone metabolic process (GO:0006743)2.45055772
98termination of RNA polymerase II transcription (GO:0006369)2.44178003
99protein deneddylation (GO:0000338)2.43830170
100postreplication repair (GO:0006301)2.40822507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.59544539
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52597500
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.33949365
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.22422977
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20998490
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.14340426
7IGF1R_20145208_ChIP-Seq_DFB_Human3.08940837
8ZNF274_21170338_ChIP-Seq_K562_Hela3.06098478
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84638616
10FUS_26573619_Chip-Seq_HEK293_Human2.49927898
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47993994
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32225447
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31489478
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.30743227
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28983253
16TAF15_26573619_Chip-Seq_HEK293_Human2.19714421
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.13231057
18GBX2_23144817_ChIP-Seq_PC3_Human2.12004122
19EWS_26573619_Chip-Seq_HEK293_Human2.06425166
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03141458
21MYC_18940864_ChIP-ChIP_HL60_Human2.02611552
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01881735
23ELK1_19687146_ChIP-ChIP_HELA_Human1.96848708
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93247056
25VDR_23849224_ChIP-Seq_CD4+_Human1.91834947
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87717438
27VDR_22108803_ChIP-Seq_LS180_Human1.81148385
28EZH2_22144423_ChIP-Seq_EOC_Human1.80600857
29FOXP3_21729870_ChIP-Seq_TREG_Human1.78377315
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73659061
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66277007
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64626542
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.62462771
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61363913
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61164452
36IRF1_19129219_ChIP-ChIP_H3396_Human1.60696674
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58544462
38E2F7_22180533_ChIP-Seq_HELA_Human1.57897024
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57140952
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54399308
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54329344
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.50008195
43GABP_19822575_ChIP-Seq_HepG2_Human1.47066114
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46894065
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46398289
46DCP1A_22483619_ChIP-Seq_HELA_Human1.42526637
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42417517
48TTF2_22483619_ChIP-Seq_HELA_Human1.42121697
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41789871
50P300_19829295_ChIP-Seq_ESCs_Human1.35928592
51TP53_22573176_ChIP-Seq_HFKS_Human1.33784980
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33051521
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.31998297
54XRN2_22483619_ChIP-Seq_HELA_Human1.28837680
55CBP_20019798_ChIP-Seq_JUKART_Human1.28141677
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28141677
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26874732
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25058217
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.24530958
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23246204
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21034091
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20988017
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17868494
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.17695073
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14871122
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13938262
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08699572
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06450729
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05790380
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03910253
71CIITA_25753668_ChIP-Seq_RAJI_Human1.00102857
72FLI1_27457419_Chip-Seq_LIVER_Mouse0.99748064
73NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98643621
74CBX2_27304074_Chip-Seq_ESCs_Mouse0.98032866
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96480195
76NANOG_16153702_ChIP-ChIP_HESCs_Human0.96451258
77POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95836761
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94198614
79ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92572625
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92104241
81ER_23166858_ChIP-Seq_MCF-7_Human0.91463622
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91206892
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91117142
84REST_21632747_ChIP-Seq_MESCs_Mouse0.88909393
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85750577
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85613754
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85319229
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.85319229
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85167774
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85070882
91NCOR_22424771_ChIP-Seq_293T_Human0.84886613
92AR_20517297_ChIP-Seq_VCAP_Human0.83951181
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83832420
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83461393
95E2F1_21310950_ChIP-Seq_MCF-7_Human0.82866931
96KDM5A_27292631_Chip-Seq_BREAST_Human0.81256852
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81161213
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80856714
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80543537
100E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80045716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.37823887
2MP0002653_abnormal_ependyma_morphology3.00004849
3MP0008877_abnormal_DNA_methylation2.64203015
4MP0002822_catalepsy2.61537102
5MP0006292_abnormal_olfactory_placode2.55176331
6MP0008058_abnormal_DNA_repair2.42262529
7MP0002102_abnormal_ear_morphology2.33998772
8MP0006072_abnormal_retinal_apoptosis2.29802349
9MP0004147_increased_porphyrin_level2.21593205
10MP0003011_delayed_dark_adaptation2.18225502
11MP0001984_abnormal_olfaction2.15643493
12MP0006276_abnormal_autonomic_nervous2.02403637
13MP0009379_abnormal_foot_pigmentation1.95613462
14MP0003880_abnormal_central_pattern1.82962383
15MP0008789_abnormal_olfactory_epithelium1.82856889
16MP0005253_abnormal_eye_physiology1.80802534
17MP0004133_heterotaxia1.80287744
18MP0003718_maternal_effect1.76025134
19MP0001529_abnormal_vocalization1.72190997
20MP0002736_abnormal_nociception_after1.68083544
21MP0004043_abnormal_pH_regulation1.67226502
22MP0001293_anophthalmia1.61305579
23MP0005551_abnormal_eye_electrophysiolog1.60913737
24MP0002234_abnormal_pharynx_morphology1.58384746
25MP0002735_abnormal_chemical_nociception1.56609321
26MP0001968_abnormal_touch/_nociception1.54018641
27MP0000631_abnormal_neuroendocrine_gland1.52857225
28MP0010094_abnormal_chromosome_stability1.51701689
29MP0003693_abnormal_embryo_hatching1.51169547
30MP0001986_abnormal_taste_sensitivity1.48911882
31MP0008995_early_reproductive_senescence1.48879379
32MP0002938_white_spotting1.46871160
33MP0000778_abnormal_nervous_system1.45950570
34MP0009745_abnormal_behavioral_response1.45903248
35MP0005499_abnormal_olfactory_system1.43787941
36MP0005394_taste/olfaction_phenotype1.43787941
37MP0003567_abnormal_fetal_cardiomyocyte1.39772666
38MP0005646_abnormal_pituitary_gland1.37198228
39MP0003941_abnormal_skin_development1.35292558
40MP0005423_abnormal_somatic_nervous1.34360454
41MP0008932_abnormal_embryonic_tissue1.33841506
42MP0002751_abnormal_autonomic_nervous1.33388347
43MP0000049_abnormal_middle_ear1.33253417
44MP0004142_abnormal_muscle_tone1.32944116
45MP0006035_abnormal_mitochondrial_morpho1.32323110
46MP0003221_abnormal_cardiomyocyte_apopto1.31487530
47MP0003122_maternal_imprinting1.25422984
48MP0003111_abnormal_nucleus_morphology1.20272659
49MP0002734_abnormal_mechanical_nocicepti1.19774760
50MP0004859_abnormal_synaptic_plasticity1.19509039
51MP0003635_abnormal_synaptic_transmissio1.17121560
52MP0002160_abnormal_reproductive_system1.15412773
53MP0002090_abnormal_vision1.15409243
54MP0003136_yellow_coat_color1.15340052
55MP0004484_altered_response_of1.14356195
56MP0003195_calcinosis1.14319734
57MP0009046_muscle_twitch1.13421089
58MP0005085_abnormal_gallbladder_physiolo1.13291284
59MP0004145_abnormal_muscle_electrophysio1.12226126
60MP0003878_abnormal_ear_physiology1.10331894
61MP0005377_hearing/vestibular/ear_phenot1.10331894
62MP0002572_abnormal_emotion/affect_behav1.09230062
63MP0003937_abnormal_limbs/digits/tail_de1.08448866
64MP0003698_abnormal_male_reproductive1.07834561
65MP0001188_hyperpigmentation1.07532931
66MP0004270_analgesia1.07174832
67MP0002064_seizures1.06936904
68MP0002210_abnormal_sex_determination1.06068169
69MP0005187_abnormal_penis_morphology1.05965880
70MP0000026_abnormal_inner_ear1.05494605
71MP0000647_abnormal_sebaceous_gland1.04584479
72MP0003119_abnormal_digestive_system1.03079365
73MP0005391_vision/eye_phenotype1.00215172
74MP0001764_abnormal_homeostasis0.99678169
75MP0003121_genomic_imprinting0.99059671
76MP0006036_abnormal_mitochondrial_physio0.97185662
77MP0003077_abnormal_cell_cycle0.96951253
78MP0001970_abnormal_pain_threshold0.96197119
79MP0001929_abnormal_gametogenesis0.95368882
80MP0002272_abnormal_nervous_system0.95030956
81MP0005195_abnormal_posterior_eye0.93984622
82MP0003938_abnormal_ear_development0.93788136
83MP0005389_reproductive_system_phenotype0.93646992
84MP0003786_premature_aging0.93173018
85MP0002063_abnormal_learning/memory/cond0.91977753
86MP0001486_abnormal_startle_reflex0.91587953
87MP0004742_abnormal_vestibular_system0.91357624
88MP0002557_abnormal_social/conspecific_i0.88625181
89MP0002752_abnormal_somatic_nervous0.88358367
90MP0002184_abnormal_innervation0.87719864
91MP0003315_abnormal_perineum_morphology0.87114559
92MP0005167_abnormal_blood-brain_barrier0.86586137
93MP0003137_abnormal_impulse_conducting0.85833150
94MP0000653_abnormal_sex_gland0.85666211
95MP0008875_abnormal_xenobiotic_pharmacok0.85495443
96MP0001145_abnormal_male_reproductive0.85350884
97MP0001286_abnormal_eye_development0.84069559
98MP0002282_abnormal_trachea_morphology0.83444978
99MP0000537_abnormal_urethra_morphology0.83333719
100MP0002928_abnormal_bile_duct0.81286811

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.64815356
2Pancreatic cysts (HP:0001737)3.44917014
3True hermaphroditism (HP:0010459)3.42324566
4Pancreatic fibrosis (HP:0100732)3.35192007
5Abnormal mitochondria in muscle tissue (HP:0008316)3.20254861
6Mitochondrial inheritance (HP:0001427)3.16473423
7Lipid accumulation in hepatocytes (HP:0006561)3.13387993
8Increased hepatocellular lipid droplets (HP:0006565)3.08544250
9Acute encephalopathy (HP:0006846)3.03412611
10Hepatocellular necrosis (HP:0001404)2.98958483
11Abnormal number of erythroid precursors (HP:0012131)2.97311797
12Colon cancer (HP:0003003)2.92261038
13Nephronophthisis (HP:0000090)2.86694771
14Progressive macrocephaly (HP:0004481)2.86617181
15Increased CSF lactate (HP:0002490)2.85619731
16Medial flaring of the eyebrow (HP:0010747)2.77533407
17Hepatic necrosis (HP:0002605)2.76472816
18Gait imbalance (HP:0002141)2.74063355
19Congenital primary aphakia (HP:0007707)2.72059065
20Molar tooth sign on MRI (HP:0002419)2.65067359
21Abnormality of midbrain morphology (HP:0002418)2.65067359
22Abnormality of cells of the erythroid lineage (HP:0012130)2.43606461
23Nephrogenic diabetes insipidus (HP:0009806)2.42671482
24Cerebral edema (HP:0002181)2.42281222
25Sclerocornea (HP:0000647)2.42170518
26Increased serum lactate (HP:0002151)2.35288520
27Abnormality of the labia minora (HP:0012880)2.35064557
28Vaginal atresia (HP:0000148)2.32022989
29Postaxial foot polydactyly (HP:0001830)2.31153075
30Renal Fanconi syndrome (HP:0001994)2.31078905
31Supernumerary spleens (HP:0009799)2.29308286
32Cystic liver disease (HP:0006706)2.26468281
33Genital tract atresia (HP:0001827)2.25886175
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25469471
35Pendular nystagmus (HP:0012043)2.20556312
36Methylmalonic acidemia (HP:0002912)2.20097403
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19627819
38Abnormality of alanine metabolism (HP:0010916)2.19627819
39Hyperalaninemia (HP:0003348)2.19627819
40Meckel diverticulum (HP:0002245)2.18752223
41Hyperglycinemia (HP:0002154)2.16034007
42Type 2 muscle fiber atrophy (HP:0003554)2.13246162
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.12216521
44Abnormality of the ileum (HP:0001549)2.11141222
45Septo-optic dysplasia (HP:0100842)2.11010673
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10612783
47Anencephaly (HP:0002323)2.10288885
48Chronic hepatic failure (HP:0100626)2.08218328
49Abolished electroretinogram (ERG) (HP:0000550)2.07928039
50Lactic acidosis (HP:0003128)2.07681836
51Muscle fiber atrophy (HP:0100295)2.05584332
52Abnormality of the renal medulla (HP:0100957)2.01167071
53Thyroid-stimulating hormone excess (HP:0002925)1.98637309
54Optic disc pallor (HP:0000543)1.96609446
55Optic nerve hypoplasia (HP:0000609)1.96384170
56Methylmalonic aciduria (HP:0012120)1.94909185
57Postaxial hand polydactyly (HP:0001162)1.94466254
58Preaxial hand polydactyly (HP:0001177)1.93153952
59Intestinal atresia (HP:0011100)1.92334346
60Bilateral microphthalmos (HP:0007633)1.92147164
61Reticulocytopenia (HP:0001896)1.91499240
62Poor head control (HP:0002421)1.90681133
63Male pseudohermaphroditism (HP:0000037)1.89937459
64Progressive inability to walk (HP:0002505)1.89195546
65Aplasia/Hypoplasia of the uvula (HP:0010293)1.89084040
66Aplasia/Hypoplasia of the sternum (HP:0006714)1.88166578
67Poor coordination (HP:0002370)1.86330208
68Abnormal lung lobation (HP:0002101)1.86196903
69Bony spicule pigmentary retinopathy (HP:0007737)1.86105529
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85803401
71Inability to walk (HP:0002540)1.84980846
72Anophthalmia (HP:0000528)1.84449848
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80424667
74Degeneration of the lateral corticospinal tracts (HP:0002314)1.80424667
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80034863
76Abnormal protein N-linked glycosylation (HP:0012347)1.80034863
77Abnormal protein glycosylation (HP:0012346)1.80034863
78Abnormal glycosylation (HP:0012345)1.80034863
79Retinitis pigmentosa (HP:0000510)1.79465604
80Lethargy (HP:0001254)1.78113883
81Shoulder girdle muscle weakness (HP:0003547)1.78010098
82Astigmatism (HP:0000483)1.77906688
83Patellar aplasia (HP:0006443)1.77267090
84Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74663518
85Dicarboxylic aciduria (HP:0003215)1.74663518
86Attenuation of retinal blood vessels (HP:0007843)1.73910132
87Abnormality of the musculature of the pelvis (HP:0001469)1.70354019
88Abnormality of the hip-girdle musculature (HP:0001445)1.70354019
89Aplasia/Hypoplasia of the patella (HP:0006498)1.70017725
90Chronic bronchitis (HP:0004469)1.68943402
91Decreased testicular size (HP:0008734)1.67939730
92Congenital, generalized hypertrichosis (HP:0004540)1.66560329
93Exercise intolerance (HP:0003546)1.66139014
94Increased intramyocellular lipid droplets (HP:0012240)1.65735849
95Bifid tongue (HP:0010297)1.63880748
96Progressive microcephaly (HP:0000253)1.63354452
97Congenital hepatic fibrosis (HP:0002612)1.63155899
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.62617688
99Bile duct proliferation (HP:0001408)1.62022090
100Abnormal biliary tract physiology (HP:0012439)1.62022090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.47347636
2MAP4K23.42568207
3CDK193.19093427
4CDC72.99295084
5NUAK12.93615505
6SRPK12.86555799
7MAP3K42.68419189
8WNK32.53261537
9MAP2K72.38335395
10BCKDK2.35425033
11DYRK22.30135610
12ZAK2.18304389
13CASK2.05895486
14BCR2.04723925
15LATS11.96700136
16MKNK11.94560187
17DYRK31.88960609
18VRK11.79347676
19NME11.77342368
20TAF11.66524432
21BLK1.63898858
22STK161.56727243
23FRK1.51825421
24TRIM281.51228175
25CSNK1G31.49670812
26PBK1.49102949
27PLK41.47566387
28CSNK1A1L1.41131651
29TESK21.39851355
30PINK11.34917334
31CSNK1G11.33971706
32RPS6KA41.33003836
33EPHA31.26415160
34CSNK1G21.19099112
35TAOK31.19096378
36ERBB31.10818529
37CCNB11.10725432
38ADRBK21.09450330
39ATR1.08843886
40BUB11.07105286
41EPHB20.96731107
42EPHA40.96178923
43GRK70.95239819
44OXSR10.95127257
45BMPR1B0.94487659
46MAP3K60.91273851
47PLK20.90478560
48PLK10.88527651
49PLK30.85884477
50NEK10.82828256
51DAPK10.82512960
52MAPKAPK50.78832490
53GRK10.77339163
54DAPK20.76010053
55GRK50.74488448
56RPS6KA50.73763845
57MAPK130.73139325
58NEK20.72937997
59CAMKK20.72210990
60PAK60.71589284
61PRKCG0.70908536
62MAP2K40.65487192
63DYRK1A0.65397014
64PRKCE0.64727477
65MKNK20.63990317
66INSRR0.63325044
67DYRK1B0.58229447
68CSNK1A10.58120657
69AURKB0.58110500
70CHEK20.57288706
71IRAK20.56049558
72TNIK0.54787222
73CAMK1D0.53620890
74TAOK10.49119604
75LIMK10.47829366
76EIF2AK30.47095649
77TLK10.45558429
78AURKA0.45509662
79MAP3K50.45448698
80PIM20.42025466
81BRD40.41822830
82CSNK2A10.41684220
83KDR0.41613699
84MARK10.41435016
85SIK20.40632860
86NTRK20.39745181
87CSNK2A20.38239876
88IRAK10.36114402
89OBSCN0.35806945
90CAMK40.35505711
91KSR10.35346346
92CAMK10.34215829
93CAMK2A0.33083992
94WNK40.32643508
95PRKACA0.31809532
96CDK30.30612692
97FGFR10.30232608
98ATM0.29376103
99ADRBK10.28876301
100PAK30.28350946

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.15980309
2Parkinsons disease_Homo sapiens_hsa050122.74910197
3Mismatch repair_Homo sapiens_hsa034302.58649708
4Homologous recombination_Homo sapiens_hsa034402.55095905
5RNA polymerase_Homo sapiens_hsa030202.53573546
6Ribosome_Homo sapiens_hsa030102.49856145
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38742923
8Base excision repair_Homo sapiens_hsa034102.33364939
9Proteasome_Homo sapiens_hsa030502.32310916
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30045307
11Fanconi anemia pathway_Homo sapiens_hsa034602.26685876
12Nicotine addiction_Homo sapiens_hsa050332.15638338
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06659251
14Spliceosome_Homo sapiens_hsa030402.06481246
15DNA replication_Homo sapiens_hsa030302.06162063
16Huntingtons disease_Homo sapiens_hsa050162.06045094
17Protein export_Homo sapiens_hsa030601.96252002
18Linoleic acid metabolism_Homo sapiens_hsa005911.81931060
19Alzheimers disease_Homo sapiens_hsa050101.78576400
20RNA degradation_Homo sapiens_hsa030181.74941803
21Propanoate metabolism_Homo sapiens_hsa006401.72600537
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62083922
23Selenocompound metabolism_Homo sapiens_hsa004501.59856993
24Butanoate metabolism_Homo sapiens_hsa006501.59543188
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56225666
26Pyruvate metabolism_Homo sapiens_hsa006201.50791650
27Steroid biosynthesis_Homo sapiens_hsa001001.50635136
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49671573
29Cardiac muscle contraction_Homo sapiens_hsa042601.48924733
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47614161
31Pyrimidine metabolism_Homo sapiens_hsa002401.42555398
32RNA transport_Homo sapiens_hsa030131.40545743
33Non-homologous end-joining_Homo sapiens_hsa034501.39267329
34Basal transcription factors_Homo sapiens_hsa030221.31154080
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29159206
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25817954
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25080663
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19489342
39Nucleotide excision repair_Homo sapiens_hsa034201.19319099
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18659767
41Sulfur relay system_Homo sapiens_hsa041221.15511524
42Caffeine metabolism_Homo sapiens_hsa002321.14816917
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.14558464
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10118242
45Ether lipid metabolism_Homo sapiens_hsa005651.08902829
46Fatty acid elongation_Homo sapiens_hsa000621.08862615
47Peroxisome_Homo sapiens_hsa041461.08547681
48Purine metabolism_Homo sapiens_hsa002300.98162215
49Fatty acid metabolism_Homo sapiens_hsa012120.97550259
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96228058
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95557515
52Regulation of autophagy_Homo sapiens_hsa041400.94860306
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93112854
54Tryptophan metabolism_Homo sapiens_hsa003800.88660971
55One carbon pool by folate_Homo sapiens_hsa006700.86642850
56Glutathione metabolism_Homo sapiens_hsa004800.86387257
57Metabolic pathways_Homo sapiens_hsa011000.84290159
58Fatty acid degradation_Homo sapiens_hsa000710.84041171
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83148487
60Cell cycle_Homo sapiens_hsa041100.82788405
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80750778
62mRNA surveillance pathway_Homo sapiens_hsa030150.80485254
63Taste transduction_Homo sapiens_hsa047420.79333236
64Nitrogen metabolism_Homo sapiens_hsa009100.78933242
65Chemical carcinogenesis_Homo sapiens_hsa052040.77076524
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76856081
67Fat digestion and absorption_Homo sapiens_hsa049750.74500405
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73197112
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70236967
70GABAergic synapse_Homo sapiens_hsa047270.69997057
71Phototransduction_Homo sapiens_hsa047440.69745219
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.66594524
73Olfactory transduction_Homo sapiens_hsa047400.65841439
74Biosynthesis of amino acids_Homo sapiens_hsa012300.61701612
75Retinol metabolism_Homo sapiens_hsa008300.61608946
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58500108
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.58022067
78Arginine and proline metabolism_Homo sapiens_hsa003300.57185161
79Morphine addiction_Homo sapiens_hsa050320.56591576
80Hedgehog signaling pathway_Homo sapiens_hsa043400.55025832
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54342651
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.54105837
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54103170
84Lysine degradation_Homo sapiens_hsa003100.46393267
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44153486
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42833634
87Ovarian steroidogenesis_Homo sapiens_hsa049130.42583924
88Arachidonic acid metabolism_Homo sapiens_hsa005900.42273725
89beta-Alanine metabolism_Homo sapiens_hsa004100.42028024
90Oocyte meiosis_Homo sapiens_hsa041140.42004047
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40933681
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36327264
93Basal cell carcinoma_Homo sapiens_hsa052170.36090624
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.35046566
95Systemic lupus erythematosus_Homo sapiens_hsa053220.34568305
96Tyrosine metabolism_Homo sapiens_hsa003500.33188289
97Glutamatergic synapse_Homo sapiens_hsa047240.33078766
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32529066
99Glycerolipid metabolism_Homo sapiens_hsa005610.31998303
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.30042717

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