CRLS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.47554488
2L-phenylalanine catabolic process (GO:0006559)6.47554488
3L-phenylalanine metabolic process (GO:0006558)6.38146914
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.38146914
5cysteine metabolic process (GO:0006534)5.73781942
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.72084638
7aromatic amino acid family catabolic process (GO:0009074)5.69077118
8alpha-linolenic acid metabolic process (GO:0036109)5.35983245
9sulfur amino acid catabolic process (GO:0000098)5.28270045
10serine family amino acid catabolic process (GO:0009071)5.16615649
11bile acid biosynthetic process (GO:0006699)5.13581373
12urea cycle (GO:0000050)5.03118048
13urea metabolic process (GO:0019627)5.03118048
14glyoxylate metabolic process (GO:0046487)4.99450924
15tryptophan catabolic process (GO:0006569)4.98740236
16indole-containing compound catabolic process (GO:0042436)4.98740236
17indolalkylamine catabolic process (GO:0046218)4.98740236
18kynurenine metabolic process (GO:0070189)4.90957889
19lysine metabolic process (GO:0006553)4.89476547
20lysine catabolic process (GO:0006554)4.89476547
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88104644
22tryptophan metabolic process (GO:0006568)4.78830098
23amino-acid betaine metabolic process (GO:0006577)4.76674227
24high-density lipoprotein particle remodeling (GO:0034375)4.75798949
25regulation of triglyceride catabolic process (GO:0010896)4.67879829
26nitrogen cycle metabolic process (GO:0071941)4.63890657
27protein carboxylation (GO:0018214)4.60169802
28peptidyl-glutamic acid carboxylation (GO:0017187)4.60169802
29negative regulation of fibrinolysis (GO:0051918)4.59755910
30glycine metabolic process (GO:0006544)4.51788040
31homocysteine metabolic process (GO:0050667)4.44417807
32acylglycerol homeostasis (GO:0055090)4.43195034
33triglyceride homeostasis (GO:0070328)4.43195034
34bile acid metabolic process (GO:0008206)4.42701903
35serine family amino acid metabolic process (GO:0009069)4.41739291
36complement activation, alternative pathway (GO:0006957)4.36700712
37alpha-amino acid catabolic process (GO:1901606)4.31936494
38regulation of fibrinolysis (GO:0051917)4.30682494
39aromatic amino acid family metabolic process (GO:0009072)4.28046615
40fatty acid beta-oxidation (GO:0006635)4.27385474
41regulation of protein activation cascade (GO:2000257)4.23845102
42plasma lipoprotein particle clearance (GO:0034381)4.22950342
43regulation of cholesterol esterification (GO:0010872)4.21866710
44protein-lipid complex remodeling (GO:0034368)4.21131882
45macromolecular complex remodeling (GO:0034367)4.21131882
46plasma lipoprotein particle remodeling (GO:0034369)4.21131882
47cellular ketone body metabolic process (GO:0046950)4.20991301
48very-low-density lipoprotein particle assembly (GO:0034379)4.16644802
49fatty acid oxidation (GO:0019395)4.15972235
50cellular amino acid catabolic process (GO:0009063)4.11688696
51tyrosine metabolic process (GO:0006570)4.11324820
52blood coagulation, intrinsic pathway (GO:0007597)4.10230446
53regulation of sequestering of triglyceride (GO:0010889)4.09795694
54lipid oxidation (GO:0034440)4.08053312
55short-chain fatty acid metabolic process (GO:0046459)4.08000352
56serine family amino acid biosynthetic process (GO:0009070)4.05009015
57valine metabolic process (GO:0006573)4.03187822
58reverse cholesterol transport (GO:0043691)4.01906123
59fatty acid catabolic process (GO:0009062)4.00027274
60negative regulation of fatty acid biosynthetic process (GO:0045717)3.97060113
61acetyl-CoA metabolic process (GO:0006084)3.96364603
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.94720454
63regulation of complement activation (GO:0030449)3.94121069
64positive regulation of lipid catabolic process (GO:0050996)3.93614445
65coenzyme catabolic process (GO:0009109)3.91786952
66monocarboxylic acid catabolic process (GO:0072329)3.90307140
67carnitine metabolic process (GO:0009437)3.86508335
68organic acid catabolic process (GO:0016054)3.86496108
69carboxylic acid catabolic process (GO:0046395)3.86496108
70cellular glucuronidation (GO:0052695)3.85070835
71branched-chain amino acid catabolic process (GO:0009083)3.84926633
72ethanol oxidation (GO:0006069)3.82551479
73negative regulation of sterol transport (GO:0032372)3.80576169
74negative regulation of cholesterol transport (GO:0032375)3.80576169
75biotin metabolic process (GO:0006768)3.79458245
76glutamate metabolic process (GO:0006536)3.75013314
77fatty acid transmembrane transport (GO:1902001)3.73382694
78cellular modified amino acid catabolic process (GO:0042219)3.72982418
79plasma lipoprotein particle assembly (GO:0034377)3.72388904
80aspartate family amino acid catabolic process (GO:0009068)3.66234338
81exogenous drug catabolic process (GO:0042738)3.64644102
822-oxoglutarate metabolic process (GO:0006103)3.64395436
83phospholipid efflux (GO:0033700)3.64185072
84acylglycerol catabolic process (GO:0046464)3.62302772
85neutral lipid catabolic process (GO:0046461)3.62302772
86triglyceride catabolic process (GO:0019433)3.61823694
87ketone body metabolic process (GO:1902224)3.60924887
88benzene-containing compound metabolic process (GO:0042537)3.60554125
89branched-chain amino acid metabolic process (GO:0009081)3.53623478
90bile acid and bile salt transport (GO:0015721)3.53189688
91ethanol metabolic process (GO:0006067)3.53056073
92pantothenate metabolic process (GO:0015939)3.51336004
93negative regulation of lipase activity (GO:0060192)3.51119131
94drug catabolic process (GO:0042737)3.50647471
95positive regulation of fatty acid oxidation (GO:0046321)3.49312273
96indolalkylamine metabolic process (GO:0006586)3.48503243
97epoxygenase P450 pathway (GO:0019373)3.47919176
98glucuronate metabolic process (GO:0019585)3.44570027
99uronic acid metabolic process (GO:0006063)3.44570027
100aldehyde catabolic process (GO:0046185)3.41527854
101low-density lipoprotein particle remodeling (GO:0034374)3.37895238
102cholesterol efflux (GO:0033344)3.35466384
103amine catabolic process (GO:0009310)3.35325193
104cellular biogenic amine catabolic process (GO:0042402)3.35325193
105carnitine shuttle (GO:0006853)3.35217617
106protein-lipid complex assembly (GO:0065005)3.27519486
107plasma lipoprotein particle organization (GO:0071827)3.24414670
108NADH metabolic process (GO:0006734)3.06864083
109omega-hydroxylase P450 pathway (GO:0097267)3.03773439
110protein-lipid complex subunit organization (GO:0071825)3.02847972
111fibrinolysis (GO:0042730)2.87696266
112drug metabolic process (GO:0017144)2.82322293
113regulation of cardioblast differentiation (GO:0051890)2.78748146
114regulation of bile acid biosynthetic process (GO:0070857)2.76563691
115protoporphyrinogen IX biosynthetic process (GO:0006782)2.74980828
116protein activation cascade (GO:0072376)2.71539229
117cardiac myofibril assembly (GO:0055003)2.70481030
1184-hydroxyproline metabolic process (GO:0019471)2.70234904
119negative regulation of protein activation cascade (GO:2000258)2.67743660
120protoporphyrinogen IX metabolic process (GO:0046501)2.65595836
121bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62040562
122intestinal cholesterol absorption (GO:0030299)2.61623447
123polyketide metabolic process (GO:0030638)2.60628134
124doxorubicin metabolic process (GO:0044598)2.60628134
125daunorubicin metabolic process (GO:0044597)2.60628134
126imidazole-containing compound metabolic process (GO:0052803)2.59318201
127primary alcohol catabolic process (GO:0034310)2.57489732
128negative regulation of hemostasis (GO:1900047)2.57401959
129negative regulation of blood coagulation (GO:0030195)2.57401959
130hormone catabolic process (GO:0042447)2.57031155
131sterol homeostasis (GO:0055092)2.55800148
132myofibril assembly (GO:0030239)2.55650996
133regulation of apoptotic cell clearance (GO:2000425)2.55465180
134cholesterol homeostasis (GO:0042632)2.55348690
135complement activation, classical pathway (GO:0006958)2.55317173
136aerobic respiration (GO:0009060)2.55266899
137positive regulation of triglyceride lipase activity (GO:0061365)2.53487264
138positive regulation of lipoprotein lipase activity (GO:0051006)2.53487264
139oxidative phosphorylation (GO:0006119)2.52838557
140regulation of plasminogen activation (GO:0010755)2.52607019
141glutamine family amino acid biosynthetic process (GO:0009084)2.50939523
142regulation of lipoprotein metabolic process (GO:0050746)2.50797322
143tricarboxylic acid cycle (GO:0006099)2.49549384
144intestinal absorption (GO:0050892)2.48860853
145regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.47837677
146angiotensin maturation (GO:0002003)2.47595159
147negative regulation of coagulation (GO:0050819)2.46349411
148drug transmembrane transport (GO:0006855)2.45484472
149oxaloacetate metabolic process (GO:0006107)2.45475407
150phospholipid homeostasis (GO:0055091)2.45045962
151regulation of humoral immune response (GO:0002920)2.44467788
152proline metabolic process (GO:0006560)2.40652871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.50251614
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.29426123
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.52492241
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.90749787
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.87341617
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.64891326
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.64180348
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.82573314
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.61456644
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.17516185
11E2F7_22180533_ChIP-Seq_HELA_Human2.86989616
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32883274
13CLOCK_20551151_ChIP-Seq_293T_Human2.31071621
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.08491367
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5823029
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98206653
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.94779169
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86958838
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81602897
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79997747
21ZNF263_19887448_ChIP-Seq_K562_Human1.75893252
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.73382124
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.60113631
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58609712
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48444173
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47250603
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41940833
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41636774
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39089729
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38705390
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34830868
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34732787
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30660075
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30660074
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29143356
36* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17795311
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17784063
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.17653453
39MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17277587
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17136040
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.16101921
42AR_21909140_ChIP-Seq_LNCAP_Human1.14213199
43* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13122309
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12812843
45CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11235570
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11148410
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07666829
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05304548
49* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05106227
50SOX17_20123909_ChIP-Seq_XEN_Mouse1.03949186
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03562066
52TCF4_18268006_ChIP-ChIP_LS174T_Human0.99427930
53FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99182776
54HTT_18923047_ChIP-ChIP_STHdh_Human0.98835310
55AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97433823
56CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97090559
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96667995
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96498635
59FOXM1_23109430_ChIP-Seq_U2OS_Human0.95784188
60RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95425559
61SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95186043
62PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94358241
63SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93336268
64EZH2_22144423_ChIP-Seq_EOC_Human0.93292222
65* GATA4_25053715_ChIP-Seq_YYC3_Human0.92596453
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92559126
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92000674
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92000674
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92000674
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90735658
71GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90377007
72TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90305835
73E2F1_21310950_ChIP-Seq_MCF-7_Human0.90113014
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90087949
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89468662
76IRF1_19129219_ChIP-ChIP_H3396_Human0.89457314
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88440060
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87156017
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86969656
80RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86802741
81SRF_21415370_ChIP-Seq_HL-1_Mouse0.86781507
82NANOG_21062744_ChIP-ChIP_HESCs_Human0.85243223
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81261732
84SOX2_20726797_ChIP-Seq_SW620_Human0.81254570
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81119790
86NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80394709
87TBX20_22080862_ChIP-Seq_HEART_Mouse0.79599412
88TBX20_22328084_ChIP-Seq_HEART_Mouse0.79599412
89EOMES_21245162_ChIP-Seq_HESCs_Human0.79398932
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79293767
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79110614
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.78227496
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78054011
94* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76783175
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75922986
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75922986
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.75648679
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71149579
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71087133
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70341998
101MYC_18555785_ChIP-Seq_MESCs_Mouse0.70205229
102PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68351754
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66511063
104EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.65026875
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64931503
106* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64701816
107* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63864994
108AR_20517297_ChIP-Seq_VCAP_Human0.62063384
109ZFX_18555785_ChIP-Seq_MESCs_Mouse0.61558674
110ERG_20517297_ChIP-Seq_VCAP_Human0.60840392
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59456391
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57773033
113STAT1_17558387_ChIP-Seq_HELA_Human0.56983489
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.56813212
115CBP_20019798_ChIP-Seq_JUKART_Human0.56813212
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.56264104
117CEBPB_22108803_ChIP-Seq_LS180_Human0.55830330
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.55371652
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.54220732
120* GATA6_25053715_ChIP-Seq_YYC3_Human0.53972094
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.53949337
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.53305383
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.53226093
124ESET_19884257_ChIP-Seq_ESCs_Mouse0.52176162
125GATA1_22025678_ChIP-Seq_K562_Human0.51904295
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.51477548
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.50990952
128MYCN_18555785_ChIP-Seq_MESCs_Mouse0.50785357
129CBP_21632823_ChIP-Seq_H3396_Human0.50394041
130DCP1A_22483619_ChIP-Seq_HELA_Human0.49272499
131P53_21459846_ChIP-Seq_SAOS-2_Human0.48508642
132E2F1_18555785_ChIP-Seq_MESCs_Mouse0.48236232
133CHD1_26751641_Chip-Seq_LNCaP_Human0.47855478
134* ATF3_27146783_Chip-Seq_COLON_Human0.47698356
135CDX2_22108803_ChIP-Seq_LS180_Human0.47545968
136BCAT_22108803_ChIP-Seq_LS180_Human0.46753740
137NANOG_16518401_ChIP-PET_MESCs_Mouse0.46735826
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.45756572
139SOX2_22085726_ChIP-Seq_NPCs_Mouse0.43867386
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.43082246
141LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.42589851
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.42163306
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41837249
144MYC_19915707_ChIP-ChIP_AK7_Human0.40782335
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.40399520
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.39374831
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.39366207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.82885969
2MP0005360_urolithiasis6.74642098
3MP0005085_abnormal_gallbladder_physiolo5.82755354
4MP0005365_abnormal_bile_salt5.73510590
5MP0008875_abnormal_xenobiotic_pharmacok4.52768866
6MP0003806_abnormal_nucleotide_metabolis3.93463852
7MP0010329_abnormal_lipoprotein_level3.53426305
8MP0003252_abnormal_bile_duct3.28615624
9MP0003195_calcinosis3.15126362
10MP0005332_abnormal_amino_acid3.02595311
11MP0009840_abnormal_foam_cell2.64774725
12MP0005083_abnormal_biliary_tract2.63690413
13MP0001666_abnormal_nutrient_absorption2.53171783
14MP0004084_abnormal_cardiac_muscle2.38816151
15MP0002118_abnormal_lipid_homeostasis2.28078235
16MP0005670_abnormal_white_adipose2.16614846
17MP0000609_abnormal_liver_physiology2.14700430
18MP0004019_abnormal_vitamin_homeostasis2.10733406
19MP0003191_abnormal_cellular_cholesterol2.05301767
20MP0004215_abnormal_myocardial_fiber2.03906829
21MP0003941_abnormal_skin_development1.93640517
22MP0003950_abnormal_plasma_membrane1.92840834
23MP0005319_abnormal_enzyme/_coenzyme1.92069323
24MP0005330_cardiomyopathy1.91767985
25MP0003868_abnormal_feces_composition1.86244719
26MP0005666_abnormal_adipose_tissue1.80425306
27MP0003186_abnormal_redox_activity1.80106156
28MP0004036_abnormal_muscle_relaxation1.79479122
29MP0004130_abnormal_muscle_cell1.77996952
30MP0009697_abnormal_copulation1.74260177
31MP0001764_abnormal_homeostasis1.72669071
32MP0003705_abnormal_hypodermis_morpholog1.70234791
33MP0002971_abnormal_brown_adipose1.61824646
34MP0004272_abnormal_basement_membrane1.61004812
35MP0005584_abnormal_enzyme/coenzyme_acti1.58703036
36MP0004145_abnormal_muscle_electrophysio1.52247768
37MP0004185_abnormal_adipocyte_glucose1.51498855
38MP0008775_abnormal_heart_ventricle1.49080839
39MP0006036_abnormal_mitochondrial_physio1.49068261
40MP0005451_abnormal_body_composition1.48964807
41MP0002138_abnormal_hepatobiliary_system1.39710092
42MP0005410_abnormal_fertilization1.39554586
43MP0000751_myopathy1.34989405
44MP0009643_abnormal_urine_homeostasis1.28959760
45MP0000598_abnormal_liver_morphology1.25547201
46MP0008057_abnormal_DNA_replication1.22861145
47MP0005647_abnormal_sex_gland1.15945807
48MP0002972_abnormal_cardiac_muscle1.15148119
49MP0005535_abnormal_body_temperature1.14127889
50MP0003011_delayed_dark_adaptation1.13942440
51MP0005334_abnormal_fat_pad1.12373613
52MP0004264_abnormal_extraembryonic_tissu1.12327719
53MP0002269_muscular_atrophy1.12118494
54MP0003656_abnormal_erythrocyte_physiolo1.11285570
55MP0000747_muscle_weakness1.10835235
56MP0004087_abnormal_muscle_fiber1.08989636
57MP0001730_embryonic_growth_arrest1.07553319
58MP0010630_abnormal_cardiac_muscle1.05484292
59MP0002078_abnormal_glucose_homeostasis1.02869907
60MP0010234_abnormal_vibrissa_follicle1.01409650
61MP0001544_abnormal_cardiovascular_syste1.01119055
62MP0005385_cardiovascular_system_phenoty1.01119055
63MP0005636_abnormal_mineral_homeostasis1.00465693
64MP0002127_abnormal_cardiovascular_syste0.99571848
65MP0000762_abnormal_tongue_morphology0.96913199
66MP0005375_adipose_tissue_phenotype0.96315465
67MP0006035_abnormal_mitochondrial_morpho0.95292962
68MP0004957_abnormal_blastocyst_morpholog0.94893705
69MP0005220_abnormal_exocrine_pancreas0.93726260
70MP0000749_muscle_degeneration0.92050292
71MP0001661_extended_life_span0.92037417
72MP0005084_abnormal_gallbladder_morpholo0.89113197
73MP0003693_abnormal_embryo_hatching0.89079051
74MP0002876_abnormal_thyroid_physiology0.88843645
75MP0002837_dystrophic_cardiac_calcinosis0.86699000
76MP0003984_embryonic_growth_retardation0.86468703
77MP0002796_impaired_skin_barrier0.85140585
78MP0009115_abnormal_fat_cell0.84867308
79MP0002088_abnormal_embryonic_growth/wei0.84206289
80MP0005620_abnormal_muscle_contractility0.82464022
81MP0009763_increased_sensitivity_to0.82387051
82MP0002970_abnormal_white_adipose0.80938069
83MP0001672_abnormal_embryogenesis/_devel0.80906447
84MP0005380_embryogenesis_phenotype0.80906447
85MP0008004_abnormal_stomach_pH0.80686900
86MP0005376_homeostasis/metabolism_phenot0.80176465
87MP0002132_abnormal_respiratory_system0.80014517
88MP0009642_abnormal_blood_homeostasis0.79706564
89MP0001697_abnormal_embryo_size0.78865415
90MP0004085_abnormal_heartbeat0.78329011
91MP0002254_reproductive_system_inflammat0.77205375
92MP0005448_abnormal_energy_balance0.76965059
93MP0003567_abnormal_fetal_cardiomyocyte0.76656360
94MP0002233_abnormal_nose_morphology0.75912002
95MP0008438_abnormal_cutaneous_collagen0.75572806
96MP0004043_abnormal_pH_regulation0.75200265
97MP0004147_increased_porphyrin_level0.74292240
98MP0000604_amyloidosis0.73872619
99MP0002086_abnormal_extraembryonic_tissu0.72803905
100MP0008932_abnormal_embryonic_tissue0.71205801
101MP0009053_abnormal_anal_canal0.70502875
102MP0003077_abnormal_cell_cycle0.70086507
103MP0000566_synostosis0.69315043
104MP0002106_abnormal_muscle_physiology0.68989756
105MP0005266_abnormal_metabolism0.68381496
106MP0005408_hypopigmentation0.68279197
107MP0001756_abnormal_urination0.67357827
108MP0003890_abnormal_embryonic-extraembry0.66383230
109MP0003699_abnormal_female_reproductive0.65202690
110MP0002089_abnormal_postnatal_growth/wei0.64675428
111MP0004484_altered_response_of0.63861878
112MP0009379_abnormal_foot_pigmentation0.62770590
113MP0000759_abnormal_skeletal_muscle0.62411233
114MP0003718_maternal_effect0.61380997
115MP0008469_abnormal_protein_level0.59941393
116MP0009765_abnormal_xenobiotic_induced0.59895185
117MP0005369_muscle_phenotype0.59803692
118MP0005165_increased_susceptibility_to0.59506202
119MP0005395_other_phenotype0.57736577
120MP0003953_abnormal_hormone_level0.55311780
121MP0009672_abnormal_birth_weight0.50769399
122MP0009764_decreased_sensitivity_to0.50681020
123MP0002060_abnormal_skin_morphology0.50472636
124MP0000639_abnormal_adrenal_gland0.47002580
125MP0003959_abnormal_lean_body0.44892091
126MP0001881_abnormal_mammary_gland0.44590058
127MP0001765_abnormal_ion_homeostasis0.44357550
128MP0002136_abnormal_kidney_physiology0.43309974
129MP0003724_increased_susceptibility_to0.43130249
130MP0003221_abnormal_cardiomyocyte_apopto0.41752958
131MP0001929_abnormal_gametogenesis0.41150612
132MP0005452_abnormal_adipose_tissue0.38655069
133MP0002168_other_aberrant_phenotype0.38546948
134MP0004782_abnormal_surfactant_physiolog0.38483144
135MP0001944_abnormal_pancreas_morphology0.38356964
136MP0002877_abnormal_melanocyte_morpholog0.37964136
137MP0003646_muscle_fatigue0.37471925
138MP0005275_abnormal_skin_tensile0.37205135
139MP0010368_abnormal_lymphatic_system0.36766686
140MP0003638_abnormal_response/metabolism_0.36671943
141MP0008873_increased_physiological_sensi0.34000078
142MP0003698_abnormal_male_reproductive0.32674273
143MP0003329_amyloid_beta_deposits0.32657192
144MP0009780_abnormal_chondrocyte_physiolo0.32012489
145MP0000230_abnormal_systemic_arterial0.31314552
146MP0000003_abnormal_adipose_tissue0.30738420
147MP0006138_congestive_heart_failure0.29461034
148MP0000427_abnormal_hair_cycle0.29352914
149MP0005248_abnormal_Harderian_gland0.29141458

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.32217089
2Deep venous thrombosis (HP:0002625)5.87339101
3Intrahepatic cholestasis (HP:0001406)5.87329997
4Hypobetalipoproteinemia (HP:0003563)5.78814599
5Xanthomatosis (HP:0000991)5.71203921
6Hyperglycinemia (HP:0002154)5.53185114
7Hyperglycinuria (HP:0003108)5.42743160
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.31831663
9Abnormality of serine family amino acid metabolism (HP:0010894)5.11669365
10Abnormality of glycine metabolism (HP:0010895)5.11669365
11Prolonged partial thromboplastin time (HP:0003645)4.86811770
12Hyperammonemia (HP:0001987)4.85967754
13Hyperlipoproteinemia (HP:0010980)4.85265256
14Hypolipoproteinemia (HP:0010981)4.59897128
15Ketosis (HP:0001946)4.44788730
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.24741495
17Abnormality of fatty-acid metabolism (HP:0004359)4.21170365
18Epidermoid cyst (HP:0200040)4.18996063
19Hypoalphalipoproteinemia (HP:0003233)4.16857189
20Hypoglycemic coma (HP:0001325)4.07135096
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01824473
22Complement deficiency (HP:0004431)4.00195645
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.96190474
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.84825860
25Abnormality of serum amino acid levels (HP:0003112)3.76190153
26Abnormality of the common coagulation pathway (HP:0010990)3.65589072
27Abnormality of the intrinsic pathway (HP:0010989)3.64875805
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.58171491
29Fat malabsorption (HP:0002630)3.56705960
30Abnormality of methionine metabolism (HP:0010901)3.56644496
31Ketoacidosis (HP:0001993)3.48816889
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.45375563
33Dicarboxylic aciduria (HP:0003215)3.45375563
34Joint hemorrhage (HP:0005261)3.44567248
35Osteomalacia (HP:0002749)3.36448142
36Hypercholesterolemia (HP:0003124)3.19044904
37Lethargy (HP:0001254)3.18408062
38Abnormality of complement system (HP:0005339)3.01824080
39Bundle branch block (HP:0011710)2.95874672
40Myocardial infarction (HP:0001658)2.94348214
41Cerebral edema (HP:0002181)2.93369726
42Metabolic acidosis (HP:0001942)2.90573583
43Abnormality of purine metabolism (HP:0004352)2.86102383
44Abnormality of nucleobase metabolism (HP:0010932)2.82491654
45Gout (HP:0001997)2.82024095
46Delayed CNS myelination (HP:0002188)2.80859152
47Spontaneous abortion (HP:0005268)2.75615564
48Abnormality of pyrimidine metabolism (HP:0004353)2.75270196
49Brushfield spots (HP:0001088)2.72866297
50Ventricular tachycardia (HP:0004756)2.71602951
51Hyperbilirubinemia (HP:0002904)2.70957508
52Steatorrhea (HP:0002570)2.70033777
53Abnormal cartilage morphology (HP:0002763)2.68180442
54Conjugated hyperbilirubinemia (HP:0002908)2.67824104
55Hepatocellular carcinoma (HP:0001402)2.66497696
56Right ventricular cardiomyopathy (HP:0011663)2.63827096
57Poikilocytosis (HP:0004447)2.62330831
58Glomerulonephritis (HP:0000099)2.59802500
59Abnormal tarsal ossification (HP:0008369)2.59061201
60Nausea (HP:0002018)2.51472487
61Vascular calcification (HP:0004934)2.49556482
62Hyperphosphaturia (HP:0003109)2.48804960
63Skin nodule (HP:0200036)2.48193190
64Sudden death (HP:0001699)2.44417082
65Generalized aminoaciduria (HP:0002909)2.44295531
66Spastic diplegia (HP:0001264)2.43857545
67Abnormality of proline metabolism (HP:0010907)2.43769828
68Hydroxyprolinuria (HP:0003080)2.43769828
69Vomiting (HP:0002013)2.42001824
70Acanthocytosis (HP:0001927)2.41854780
71Proximal tubulopathy (HP:0000114)2.40481134
72Heart block (HP:0012722)2.36461690
73Atrioventricular block (HP:0001678)2.35217037
74Rickets (HP:0002748)2.33707081
75Abnormal urine phosphate concentration (HP:0012599)2.32546209
76Renal cortical cysts (HP:0000803)2.30367205
77Malnutrition (HP:0004395)2.29334769
78Flat acetabular roof (HP:0003180)2.28645933
79Abnormality of glycolysis (HP:0004366)2.26285837
80Increased serum pyruvate (HP:0003542)2.26285837
81Pancreatitis (HP:0001733)2.26055611
82Abnormality of carpal bone ossification (HP:0006257)2.25561286
83Cardiovascular calcification (HP:0011915)2.25351868
84Irritability (HP:0000737)2.24198156
85Papillary thyroid carcinoma (HP:0002895)2.24126798
86Abnormal atrioventricular conduction (HP:0005150)2.22229853
87Hyperglycemia (HP:0003074)2.22079455
88Renal Fanconi syndrome (HP:0001994)2.21335454
89Hyperuricemia (HP:0002149)2.20989607
90Increased purine levels (HP:0004368)2.20989607
91Rimmed vacuoles (HP:0003805)2.17811563
92Systemic lupus erythematosus (HP:0002725)2.10912778
93Enlarged kidneys (HP:0000105)2.08672657
94Hypertriglyceridemia (HP:0002155)2.08316450
95Increased muscle lipid content (HP:0009058)2.07331212
96Palpitations (HP:0001962)2.06457217
97Reduced antithrombin III activity (HP:0001976)2.05932330
98Hypochromic microcytic anemia (HP:0004840)2.02984758
99Abnormality of the left ventricular outflow tract (HP:0011103)2.01468895
100Subaortic stenosis (HP:0001682)2.01468895
101Methylmalonic aciduria (HP:0012120)2.01226967
102Dilated cardiomyopathy (HP:0001644)2.00098098
103Increased intramyocellular lipid droplets (HP:0012240)1.97309251
104Lipid accumulation in hepatocytes (HP:0006561)1.96256551
105Lipoatrophy (HP:0100578)1.94778837
106Abnormal gallbladder morphology (HP:0012437)1.94556722
107Rhabdomyolysis (HP:0003201)1.94154304
108Male infertility (HP:0003251)1.92766583
109Global brain atrophy (HP:0002283)1.91914459
110Mitral stenosis (HP:0001718)1.91442488
111Increased hepatocellular lipid droplets (HP:0006565)1.91429604
112Sensorimotor neuropathy (HP:0007141)1.91298325
113Neonatal onset (HP:0003623)1.90344752
114Myoglobinuria (HP:0002913)1.89389868
115Abnormality of the calf musculature (HP:0001430)1.89262138
116Abnormal gallbladder physiology (HP:0012438)1.88751175
117Cholecystitis (HP:0001082)1.88751175
118Hepatic necrosis (HP:0002605)1.88567576
119Abnormality of the Achilles tendon (HP:0005109)1.88128661
120Megaloblastic anemia (HP:0001889)1.86980155
121Abnormality of vitamin metabolism (HP:0100508)1.86903846
122Multiple enchondromatosis (HP:0005701)1.85974276
123Gonadal dysgenesis (HP:0000133)1.84970589
124Abnormality of urine glucose concentration (HP:0011016)1.83726810
125Glycosuria (HP:0003076)1.83726810
126Premature ovarian failure (HP:0008209)1.83688631
127Protuberant abdomen (HP:0001538)1.83293058
128Acute encephalopathy (HP:0006846)1.81086134
129Cholelithiasis (HP:0001081)1.80970363
130Hypoglycemic seizures (HP:0002173)1.79497184
131Epiphyseal stippling (HP:0010655)1.79056899
132Abnormal foot bone ossification (HP:0010675)1.77675434
133Hyperinsulinemic hypoglycemia (HP:0000825)1.77162310
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77075563
135Abnormality of alanine metabolism (HP:0010916)1.77075563
136Hyperalaninemia (HP:0003348)1.77075563
137Ileus (HP:0002595)1.76707915
138Muscle fiber inclusion bodies (HP:0100299)1.75127395
139Hypophosphatemic rickets (HP:0004912)1.74757682
140Prenatal maternal abnormality (HP:0002686)1.74729118
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.74688214
142Opisthotonus (HP:0002179)1.74076537
143Respiratory distress (HP:0002098)1.73412265
144Abnormality of the gallbladder (HP:0005264)1.72211828
145Late onset (HP:0003584)1.71568015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.02718659
2PDK35.12205998
3PDK45.12205998
4OBSCN4.01749461
5TRIB33.32513995
6PDK23.11769102
7PKN22.93880183
8FRK2.74212846
9ERN12.53153859
10LATS12.51790654
11SIK12.51253157
12STK38L2.49937054
13MYLK2.39365028
14DMPK2.25976143
15MST42.15485680
16EIF2AK11.98719387
17CDK81.90794544
18NME21.82794871
19NEK91.79006326
20PLK41.75609558
21LMTK21.66764438
22MAP2K41.61971279
23ABL21.61930099
24FGFR41.61650565
25ERBB41.60133223
26BMPR1B1.57225501
27MAP3K121.56576938
28STK31.54306518
29VRK21.48588592
30LRRK21.46936644
31FLT31.45055759
32TTN1.40245148
33MST1R1.33242114
34PRKD31.18968623
35CAMK1D1.18709147
36FER1.18187270
37MAP3K91.13600736
38MAPKAPK31.13443921
39CDK71.12184622
40AKT31.11852253
41PINK11.11261580
42TIE11.10389104
43LATS21.08262122
44MAPK111.07404969
45CDK61.06503902
46VRK11.03450473
47PDPK11.02940694
48ILK0.96172969
49PRKAA20.95445580
50PDK10.95000031
51BRSK20.93191375
52TRPM70.90813105
53AKT20.90307516
54PTK60.88022844
55ACVR1B0.87210670
56MUSK0.85433281
57SMG10.83194366
58MAP3K30.83110323
59STK240.82455338
60SCYL20.81856203
61MAP3K130.81708430
62NUAK10.80607581
63MAP2K10.79677899
64CCNB10.79517142
65ZAK0.79400502
66EEF2K0.79204923
67CDK40.79047009
68MAPKAPK50.76085724
69RPS6KB20.75762440
70TNIK0.75184640
71STK40.72122560
72AURKB0.69944582
73TGFBR10.69813136
74RAF10.68372123
75TAF10.68326601
76TTK0.67090283
77MKNK20.63065047
78PTK2B0.63049636
79NLK0.63018247
80CAMK2D0.62744448
81PAK20.61848831
82MET0.61285713
83BRAF0.58757294
84KSR20.57708384
85PRKG20.57654111
86GRK60.56969647
87WNK10.56937834
88PRKAA10.56911535
89RPS6KB10.56066163
90PRKACG0.55900486
91WNK40.55564003
92PLK10.55142113
93MAP2K30.54632160
94FGFR10.54414901
95STK380.54108965
96TAOK30.54021695
97WEE10.53922935
98CAMK1G0.53397072
99PRKCZ0.52686599
100STK390.51971077
101PLK30.51845115
102EPHA40.51466577
103JAK20.50922214
104NME10.50081676
105ARAF0.48558410
106SGK30.47458539
107CHEK20.46552400
108TESK10.46514746
109DDR20.46153494
110MKNK10.46029336
111MAP3K60.45886184
112STK160.45594233
113GSK3A0.45474263
114MELK0.45158586
115BUB10.45026646
116FGFR20.44636718
117MAPK40.43213295
118MAP3K50.42988783
119RPS6KA40.42546616
120MAP3K70.42392948
121PTK20.41560599
122IRAK30.41412056
123CDK90.40982893
124PIK3CA0.40115040
125PLK20.39271400
126PIK3CG0.38932816
127EIF2AK30.38593312
128DYRK1B0.35499814
129PRKCG0.34582725
130MAP3K40.34239572
131NEK10.33490445
132CSNK2A20.33158502
133CSNK1E0.30881621
134KSR10.30040186
135NEK20.29473718
136CAMK2G0.29113702
137MTOR0.29060424
138PBK0.27524751
139FGFR30.26450612
140AURKA0.26286227
141CSNK1G10.24776359
142SGK20.24746292
143IRAK10.24357777
144MOS0.23990957
145CSNK2A10.22690023
146IGF1R0.21253636
147PIM10.21068528
148RET0.20650217
149MAP2K20.19842098
150PDGFRA0.18765363
151BMX0.18598794
152MAP2K60.18590596
153MAP3K80.18035831

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.77377859
2Nitrogen metabolism_Homo sapiens_hsa009103.24694770
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.07307956
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97855215
5Fatty acid degradation_Homo sapiens_hsa000712.97810526
6Propanoate metabolism_Homo sapiens_hsa006402.87557899
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.84920812
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68988723
9Arginine biosynthesis_Homo sapiens_hsa002202.59851969
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57861918
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47187657
12Tryptophan metabolism_Homo sapiens_hsa003802.33583293
13Fatty acid metabolism_Homo sapiens_hsa012122.29510046
14PPAR signaling pathway_Homo sapiens_hsa033202.28313960
15Peroxisome_Homo sapiens_hsa041462.17067109
16Butanoate metabolism_Homo sapiens_hsa006502.15719847
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14341378
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06721738
19Complement and coagulation cascades_Homo sapiens_hsa046102.04756595
20Pyruvate metabolism_Homo sapiens_hsa006201.95333574
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86047880
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83555116
23Chemical carcinogenesis_Homo sapiens_hsa052041.72599404
24beta-Alanine metabolism_Homo sapiens_hsa004101.72120721
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71631995
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71491868
27Carbon metabolism_Homo sapiens_hsa012001.66700400
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60713662
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60373666
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.59375528
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.57921514
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57165496
33Selenocompound metabolism_Homo sapiens_hsa004501.54836349
34Sulfur metabolism_Homo sapiens_hsa009201.50467530
35Fatty acid elongation_Homo sapiens_hsa000621.45250850
36Biosynthesis of amino acids_Homo sapiens_hsa012301.44311548
37Folate biosynthesis_Homo sapiens_hsa007901.43580909
38Histidine metabolism_Homo sapiens_hsa003401.43191822
39Retinol metabolism_Homo sapiens_hsa008301.42709829
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.41916708
41Vitamin B6 metabolism_Homo sapiens_hsa007501.40262984
42Fat digestion and absorption_Homo sapiens_hsa049751.37037655
43Phenylalanine metabolism_Homo sapiens_hsa003601.35385217
44Caffeine metabolism_Homo sapiens_hsa002321.33346879
45Sulfur relay system_Homo sapiens_hsa041221.25962548
46Bile secretion_Homo sapiens_hsa049761.22984870
47Tyrosine metabolism_Homo sapiens_hsa003501.19595721
48Starch and sucrose metabolism_Homo sapiens_hsa005001.18131426
49Fatty acid biosynthesis_Homo sapiens_hsa000611.17522320
50Glycerolipid metabolism_Homo sapiens_hsa005611.14405878
51Staphylococcus aureus infection_Homo sapiens_hsa051501.13194841
52Ribosome_Homo sapiens_hsa030101.13171863
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12090219
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09894690
55Steroid biosynthesis_Homo sapiens_hsa001001.08618915
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.99866851
57Pentose phosphate pathway_Homo sapiens_hsa000300.91904989
58One carbon pool by folate_Homo sapiens_hsa006700.83166643
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82361962
60Vitamin digestion and absorption_Homo sapiens_hsa049770.81348783
61Cardiac muscle contraction_Homo sapiens_hsa042600.80152831
62Arginine and proline metabolism_Homo sapiens_hsa003300.78082614
63Glutathione metabolism_Homo sapiens_hsa004800.77864563
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71286485
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70041231
66Lysine degradation_Homo sapiens_hsa003100.69964225
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.69881624
68Systemic lupus erythematosus_Homo sapiens_hsa053220.68437563
69Mineral absorption_Homo sapiens_hsa049780.68428935
70ABC transporters_Homo sapiens_hsa020100.67980326
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61887769
72Basal transcription factors_Homo sapiens_hsa030220.60980395
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60149697
74* Metabolic pathways_Homo sapiens_hsa011000.56512252
75Base excision repair_Homo sapiens_hsa034100.48086031
76ECM-receptor interaction_Homo sapiens_hsa045120.47181097
77Mismatch repair_Homo sapiens_hsa034300.44476226
78Dilated cardiomyopathy_Homo sapiens_hsa054140.43572910
79Fructose and mannose metabolism_Homo sapiens_hsa000510.43472774
80N-Glycan biosynthesis_Homo sapiens_hsa005100.42521378
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.40747354
82DNA replication_Homo sapiens_hsa030300.40477854
83Glucagon signaling pathway_Homo sapiens_hsa049220.40110980
84Nucleotide excision repair_Homo sapiens_hsa034200.37177142
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35119519
86Cell cycle_Homo sapiens_hsa041100.34998872
87RNA transport_Homo sapiens_hsa030130.33512012
88AMPK signaling pathway_Homo sapiens_hsa041520.33082732
89RNA degradation_Homo sapiens_hsa030180.31234948
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30926319
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29792769
92Insulin resistance_Homo sapiens_hsa049310.29514143
93Galactose metabolism_Homo sapiens_hsa000520.28631418
94Linoleic acid metabolism_Homo sapiens_hsa005910.22317414
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21847180
96* Glycerophospholipid metabolism_Homo sapiens_hsa005640.18869107
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17239559
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11429905
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08010793
100Insulin signaling pathway_Homo sapiens_hsa049100.06119459
101Prion diseases_Homo sapiens_hsa050200.05169049
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.03191188
103Renin-angiotensin system_Homo sapiens_hsa046140.01479456
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1403369
105Alzheimers disease_Homo sapiens_hsa05010-0.1360160
106Parkinsons disease_Homo sapiens_hsa05012-0.1257728
107Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1240984
108Protein export_Homo sapiens_hsa03060-0.1229081
109Huntingtons disease_Homo sapiens_hsa05016-0.1106089
110Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0983331
111Thyroid cancer_Homo sapiens_hsa05216-0.0975148
112Pyrimidine metabolism_Homo sapiens_hsa00240-0.0874490
113Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0778223
114Protein digestion and absorption_Homo sapiens_hsa04974-0.0750997
115Oxidative phosphorylation_Homo sapiens_hsa00190-0.0509574
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0502968
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0463373
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0110395

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