CRISP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.95078212
2spermatid development (GO:0007286)9.28968566
3motile cilium assembly (GO:0044458)9.24031455
4protein targeting to Golgi (GO:0000042)8.68933600
5piRNA metabolic process (GO:0034587)8.53691386
6male meiosis (GO:0007140)8.40254706
7cilium movement (GO:0003341)8.34080144
8establishment of protein localization to Golgi (GO:0072600)8.32071033
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.14611958
10retrograde transport, vesicle recycling within Golgi (GO:0000301)8.14024344
11single fertilization (GO:0007338)7.79298505
12synaptonemal complex organization (GO:0070193)7.77668130
13synaptonemal complex assembly (GO:0007130)7.58487130
14regulation of cilium movement (GO:0003352)7.56150959
15rRNA methylation (GO:0031167)7.55293799
16phosphatidylethanolamine biosynthetic process (GO:0006646)7.04415966
17sperm capacitation (GO:0048240)6.88788634
18phosphatidylethanolamine metabolic process (GO:0046337)6.53205582
19fertilization (GO:0009566)6.52559146
20rRNA modification (GO:0000154)6.35391011
21protein localization to Golgi apparatus (GO:0034067)6.23192299
22spermatogenesis (GO:0007283)6.10860418
23negative regulation of inclusion body assembly (GO:0090084)6.08858726
24male gamete generation (GO:0048232)6.08672654
25response to pheromone (GO:0019236)5.83646366
26microtubule depolymerization (GO:0007019)5.71800139
27gamete generation (GO:0007276)5.59874289
28DNA methylation involved in gamete generation (GO:0043046)5.57640947
29RNA destabilization (GO:0050779)5.53445829
30organic cation transport (GO:0015695)5.42372488
31spermatid nucleus differentiation (GO:0007289)5.37095128
32chromosome organization involved in meiosis (GO:0070192)5.33795700
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.30941279
34ventricular system development (GO:0021591)5.26060349
35germ cell development (GO:0007281)5.24118616
36male meiosis I (GO:0007141)5.17200129
37calcium ion-dependent exocytosis (GO:0017156)5.10572061
38cell recognition (GO:0008037)5.08481289
39regulation of inclusion body assembly (GO:0090083)5.06377973
40meiotic nuclear division (GO:0007126)4.80347420
41positive regulation of Rab GTPase activity (GO:0032851)4.60123482
42regulation of Rab GTPase activity (GO:0032313)4.60123482
43seminiferous tubule development (GO:0072520)4.50503820
44microtubule nucleation (GO:0007020)4.49520540
45microtubule severing (GO:0051013)4.47074120
46regulation of microtubule-based movement (GO:0060632)4.45390663
47glycerol ether metabolic process (GO:0006662)4.40874022
48multicellular organismal reproductive process (GO:0048609)4.39957140
49musculoskeletal movement (GO:0050881)4.39446619
50multicellular organismal movement (GO:0050879)4.39446619
51glomerular visceral epithelial cell development (GO:0072015)4.35999913
52monoubiquitinated protein deubiquitination (GO:0035520)4.30770999
53regulation of transcription involved in cell fate commitment (GO:0060850)4.24683950
54glomerular epithelial cell development (GO:0072310)4.21655434
55cellular ketone body metabolic process (GO:0046950)4.20188651
56meiosis I (GO:0007127)4.14632876
57ether metabolic process (GO:0018904)4.07432068
58genitalia morphogenesis (GO:0035112)3.89850333
59chaperone-mediated protein complex assembly (GO:0051131)3.82155674
60membrane protein intracellular domain proteolysis (GO:0031293)3.75270614
61left/right pattern formation (GO:0060972)3.72826704
62meiotic cell cycle (GO:0051321)3.70479597
63ketone body metabolic process (GO:1902224)3.69677845
64protein localization to cilium (GO:0061512)3.66540125
65chromatin silencing (GO:0006342)3.65387378
66sexual reproduction (GO:0019953)3.63177517
67chromosome condensation (GO:0030261)3.62776305
68single strand break repair (GO:0000012)3.62240216
69protein K11-linked deubiquitination (GO:0035871)3.58026176
70multicellular organismal development (GO:0007275)3.56101690
71polyamine biosynthetic process (GO:0006596)3.50549430
72RNA localization (GO:0006403)3.44868603
73DNA packaging (GO:0006323)3.43040393
74intra-Golgi vesicle-mediated transport (GO:0006891)3.41311110
75protein polyglutamylation (GO:0018095)3.34919413
76intraciliary transport (GO:0042073)3.30573490
77synapsis (GO:0007129)3.27303428
78lactate metabolic process (GO:0006089)3.24176985
79regulation of interleukin-13 production (GO:0032656)3.22380923
80pore complex assembly (GO:0046931)3.20900475
81cellular response to pH (GO:0071467)3.18530559
82response to acidic pH (GO:0010447)3.17114800
83homeostasis of number of cells within a tissue (GO:0048873)3.17097457
84protein depolymerization (GO:0051261)3.16340325
85gene silencing by RNA (GO:0031047)3.15588163
86Golgi to endosome transport (GO:0006895)3.15137533
87nuclear pore organization (GO:0006999)3.13092568
88alditol metabolic process (GO:0019400)3.11508605
89polyol catabolic process (GO:0046174)3.11468819
90protein-DNA complex disassembly (GO:0032986)3.11090046
91nucleosome disassembly (GO:0006337)3.11090046
92mitochondrial fission (GO:0000266)3.09866263
93carnitine transport (GO:0015879)3.09723000
94amino-acid betaine transport (GO:0015838)3.09723000
95centriole assembly (GO:0098534)3.07902196
96negative regulation of Rho protein signal transduction (GO:0035024)3.06459169
97microtubule-based movement (GO:0007018)3.03833641
98meiotic cell cycle process (GO:1903046)3.03693332
99carnitine transmembrane transport (GO:1902603)3.01514797
100cilium organization (GO:0044782)3.01026305
101vesicle transport along microtubule (GO:0047496)3.01013312
102cerebral cortex neuron differentiation (GO:0021895)2.99339367
103nucleoside diphosphate phosphorylation (GO:0006165)2.98961981
104sequestering of actin monomers (GO:0042989)2.98930476
105glycolytic process (GO:0006096)2.98207961
106centrosome duplication (GO:0051298)2.98092802
107positive regulation of guanylate cyclase activity (GO:0031284)2.97956650
108microtubule polymerization or depolymerization (GO:0031109)2.96583005
109GTP biosynthetic process (GO:0006183)2.96469561
110protein refolding (GO:0042026)2.95011807
111mitotic G1 DNA damage checkpoint (GO:0031571)2.94372618
112centriole replication (GO:0007099)2.92943830
113axoneme assembly (GO:0035082)2.92362791
114regulation of spindle checkpoint (GO:0090231)2.91291430
115histone H3-K9 demethylation (GO:0033169)2.89774444
116receptor recycling (GO:0001881)2.89451595
117regulation of phosphoprotein phosphatase activity (GO:0043666)2.88971480
118regulation of somitogenesis (GO:0014807)2.87291927
119cilium assembly (GO:0042384)2.87225477
120cellular component assembly involved in morphogenesis (GO:0010927)2.87157228
121negative regulation of organelle assembly (GO:1902116)2.86177368
122regulation of T-helper 2 cell differentiation (GO:0045628)2.84876595
123nucleus organization (GO:0006997)2.83899462
124regulation of centriole replication (GO:0046599)2.82177893
125cilium morphogenesis (GO:0060271)2.76553054
126glycerol metabolic process (GO:0006071)2.74693761
127nuclear pore complex assembly (GO:0051292)2.71960476
128mitotic sister chromatid cohesion (GO:0007064)2.71788629
129UTP biosynthetic process (GO:0006228)2.64825932
130regulation of meiosis I (GO:0060631)2.61217371
131gene silencing (GO:0016458)2.48860782
132regulation of protein polyubiquitination (GO:1902914)2.45920389
133single-organism membrane fusion (GO:0044801)2.45752620
134fusion of sperm to egg plasma membrane (GO:0007342)14.7878609
135cell wall macromolecule catabolic process (GO:0016998)13.3387530
136cell wall macromolecule metabolic process (GO:0044036)13.3387530
137sperm motility (GO:0030317)12.9285629
138acrosome assembly (GO:0001675)12.5143168
139cilium or flagellum-dependent cell motility (GO:0001539)12.4229060
140multicellular organism reproduction (GO:0032504)11.9584041
141sperm-egg recognition (GO:0035036)11.7159653
142plasma membrane fusion (GO:0045026)11.2822219
143acrosome reaction (GO:0007340)10.6838636
144binding of sperm to zona pellucida (GO:0007339)10.5629540
145cell-cell recognition (GO:0009988)10.4985337
146axonemal dynein complex assembly (GO:0070286)10.2343762
147reproduction (GO:0000003)10.1080421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.10532221
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.70178550
3EZH2_22144423_ChIP-Seq_EOC_Human4.33146716
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.16840571
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.72493000
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40961296
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.37747237
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00460593
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63771518
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.60392216
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41790428
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25371121
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.25350419
14ZNF274_21170338_ChIP-Seq_K562_Hela2.18782565
15FUS_26573619_Chip-Seq_HEK293_Human2.18728716
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18151967
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09709012
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.09273856
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05843175
20DROSHA_22980978_ChIP-Seq_HELA_Human2.01057690
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3637245
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.95050239
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.94866359
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93162039
25VDR_22108803_ChIP-Seq_LS180_Human1.92906615
26RAC3_21632823_ChIP-Seq_H3396_Human1.84168774
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.82873963
28* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.82313434
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.80112171
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.78929587
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.77183804
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71859122
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70130877
34ERA_21632823_ChIP-Seq_H3396_Human1.68699445
35STAT1_17558387_ChIP-Seq_HELA_Human1.66891486
36NANOG_20526341_ChIP-Seq_ESCs_Human1.64725086
37GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.64168061
38CTCF_27219007_Chip-Seq_Bcells_Human1.63938146
39KDM2B_26808549_Chip-Seq_REH_Human1.63159232
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.62330244
41TAL1_26923725_Chip-Seq_HPCs_Mouse1.60695433
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59274379
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.58621513
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.56600050
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.55365202
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.54848202
47MYC_19829295_ChIP-Seq_ESCs_Human1.53763918
48ER_23166858_ChIP-Seq_MCF-7_Human1.53698290
49CBX2_22325352_ChIP-Seq_293T-Rex_Human1.52720374
50RBPJ_21746931_ChIP-Seq_IB4_Human1.52485789
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51423429
52MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49325069
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49009022
54SMC4_20622854_ChIP-Seq_HELA_Human1.48261714
55HNFA_21074721_ChIP-Seq_CACO-2_Human1.48243309
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48120725
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.47455388
58BCL6_27268052_Chip-Seq_Bcells_Human1.46366533
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.46218883
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45998669
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45196524
62* TAF2_19829295_ChIP-Seq_ESCs_Human1.45147055
63ETV1_20927104_ChIP-Seq_GIST48_Human1.44380054
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42875928
65CBP_20019798_ChIP-Seq_JUKART_Human1.42875928
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.41521253
67AR_25329375_ChIP-Seq_VCAP_Human1.41162548
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41012603
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40520903
70SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40273109
71OCT4_20526341_ChIP-Seq_ESCs_Human1.40156065
72* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37648662
73BCOR_27268052_Chip-Seq_Bcells_Human1.37375184
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.35753129
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.35742701
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.35369763
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35360766
78TP63_22573176_ChIP-Seq_HFKS_Human1.35189647
79CTCF_20526341_ChIP-Seq_ESCs_Human1.34079843
80NFYB_21822215_ChIP-Seq_K562_Human1.33207113
81P68_20966046_ChIP-Seq_HELA_Human1.33005438
82PHF8_20622854_ChIP-Seq_HELA_Human1.32278160
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32212777
84TP53_18474530_ChIP-ChIP_U2OS_Human1.32040036
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.31205901
86CEBPB_22108803_ChIP-Seq_LS180_Human1.30856432
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.29907509
88SMAD3_21741376_ChIP-Seq_ESCs_Human1.29049929
89TBL1_22424771_ChIP-Seq_293T_Human1.29033696
90LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28234266
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28029985
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27662518
93P300_19829295_ChIP-Seq_ESCs_Human1.27287922
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26775114
95E2F1_20622854_ChIP-Seq_HELA_Human1.25764811
96PHF8_20622853_ChIP-Seq_HELA_Human1.24497117
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.24136928
98* GATA3_21867929_ChIP-Seq_TH1_Mouse1.22043087
99REST_21632747_ChIP-Seq_MESCs_Mouse1.20672556
100* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20636945
101GATA6_21074721_ChIP-Seq_CACO-2_Human1.20635735
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20606931
103P53_22387025_ChIP-Seq_ESCs_Mouse1.20095472
104KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19942143
105P300_27268052_Chip-Seq_Bcells_Human1.18985412
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.18944827
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.18757369
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18704433
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18098298
110RNF2_27304074_Chip-Seq_NSC_Mouse1.17705795
111PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17331536
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17192701
113P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.17085903
114P300_18555785_Chip-Seq_ESCs_Mouse1.16889467
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16233353
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.15661420
117LXR_22292898_ChIP-Seq_THP-1_Human1.15443112
118P53_21459846_ChIP-Seq_SAOS-2_Human1.15253591
119SMAD4_21799915_ChIP-Seq_A2780_Human1.14465845
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13897064
121SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13881720
122GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13784698
123GF1_26923725_Chip-Seq_HPCs_Mouse1.13719494
124TAF15_26573619_Chip-Seq_HEK293_Human1.13230488
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12546221
126NFYA_21822215_ChIP-Seq_K562_Human1.12526059
127KLF4_18555785_Chip-Seq_ESCs_Mouse1.11565501
128SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11556242
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11236285
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10764214
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10049069
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10049069
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09955638
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09732162
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08424496
136OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08230911
137GATA3_21878914_ChIP-Seq_MCF-7_Human1.08161094
138ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07589298
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06083205
140RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05920151
141SMRT_27268052_Chip-Seq_Bcells_Human1.05805461
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04799823
143* STAT3_23295773_ChIP-Seq_U87_Human1.04709395
144STAT3_18555785_Chip-Seq_ESCs_Mouse1.04398442
145SMAD4_21741376_ChIP-Seq_HESCs_Human1.03994091
146SALL1_21062744_ChIP-ChIP_HESCs_Human1.03714512
147RUNX2_22187159_ChIP-Seq_PCA_Human1.03300984
148SA1_27219007_Chip-Seq_Bcells_Human1.03286496
149KLF5_25053715_ChIP-Seq_YYC3_Human1.02816675
150TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00712544
151ESET_19884257_ChIP-Seq_ESCs_Mouse1.00165776
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99929054
153* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99086348
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98567369
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.98418491
156KLF4_19829295_ChIP-Seq_ESCs_Human0.98164451
157PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98150660
158SPI1_26923725_Chip-Seq_HPCs_Mouse0.97599981
159SOX9_26525672_Chip-Seq_HEART_Mouse0.96128926
160OCT1_27270436_Chip-Seq_PROSTATE_Human0.95994485
161PU1_27457419_Chip-Seq_LIVER_Mouse0.95780402
162CTCF_18555785_Chip-Seq_ESCs_Mouse0.95281100
163RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94727113
164GF1B_26923725_Chip-Seq_HPCs_Mouse0.93433063
165ERG_20517297_ChIP-Seq_VCAP_Human0.93428598
166PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93317718
167E2F1_18555785_Chip-Seq_ESCs_Mouse0.92964276
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91485162
169CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90507832
170LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90033784
171SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89123824
172NMYC_18555785_Chip-Seq_ESCs_Mouse0.87828717
173SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87288172
174ZFX_18555785_Chip-Seq_ESCs_Mouse0.86569333
175FLI1_21867929_ChIP-Seq_CD8_Mouse0.86030750
176* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86003826
177RARA_24833708_ChIP-Seq_LIVER_Mouse0.85841713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.15756432
2MP0001929_abnormal_gametogenesis5.65856806
3MP0008877_abnormal_DNA_methylation5.06139303
4MP0002210_abnormal_sex_determination3.74122657
5MP0002161_abnormal_fertility/fecundity3.32411286
6MP0001145_abnormal_male_reproductive3.15889580
7MP0001348_abnormal_lacrimal_gland3.01104364
8MP0002653_abnormal_ependyma_morphology2.89616916
9MP0000653_abnormal_sex_gland2.75281272
10MP0005451_abnormal_body_composition2.24732228
11MP0003718_maternal_effect2.18329685
12MP0005670_abnormal_white_adipose2.11699091
13MP0001485_abnormal_pinna_reflex2.01558573
14MP0005410_abnormal_fertilization15.8042574
15MP0005623_abnormal_meninges_morphology1.88442392
16MP0000678_abnormal_parathyroid_gland1.84973777
17MP0005310_abnormal_salivary_gland1.81084913
18MP0002160_abnormal_reproductive_system1.74297975
19MP0005423_abnormal_somatic_nervous1.59829930
20MP0001486_abnormal_startle_reflex1.58579022
21MP0005379_endocrine/exocrine_gland_phen1.52867333
22MP0008057_abnormal_DNA_replication1.41105673
23MP0002282_abnormal_trachea_morphology1.33611159
24MP0008058_abnormal_DNA_repair1.32871872
25MP0004859_abnormal_synaptic_plasticity1.31829525
26MP0002822_catalepsy1.30059456
27MP0004233_abnormal_muscle_weight1.29356393
28MP0004742_abnormal_vestibular_system1.28765982
29MP0009046_muscle_twitch1.20717544
30MP0002249_abnormal_larynx_morphology1.18199077
31MP0005647_abnormal_sex_gland1.18096651
32MP0001963_abnormal_hearing_physiology1.17768436
33MP0001765_abnormal_ion_homeostasis1.16788216
34MP0003646_muscle_fatigue1.16503071
35MP0001984_abnormal_olfaction1.07354681
36MP0002138_abnormal_hepatobiliary_system1.04706539
37MP0009053_abnormal_anal_canal1.01426571
38MP0005395_other_phenotype0.98779614
39MP0000026_abnormal_inner_ear0.94849878
40MP0010094_abnormal_chromosome_stability0.92490501
41MP0002735_abnormal_chemical_nociception0.90948308
42MP0008995_early_reproductive_senescence0.90031666
43MP0005389_reproductive_system_phenotype0.89539846
44MP0000955_abnormal_spinal_cord0.87633029
45MP0005083_abnormal_biliary_tract0.84339944
46MP0003011_delayed_dark_adaptation0.83644538
47MP0009697_abnormal_copulation0.83567714
48MP0002127_abnormal_cardiovascular_syste0.83030911
49MP0004510_myositis0.77324053
50MP0002067_abnormal_sensory_capabilities0.76603309
51MP0005248_abnormal_Harderian_gland0.76321313
52MP0008569_lethality_at_weaning0.76289098
53MP0002234_abnormal_pharynx_morphology0.72635986
54MP0005375_adipose_tissue_phenotype0.71761216
55MP0002557_abnormal_social/conspecific_i0.70610901
56MP0001905_abnormal_dopamine_level0.67795375
57MP0003786_premature_aging0.65997405
58MP0005167_abnormal_blood-brain_barrier0.63920159
59MP0005636_abnormal_mineral_homeostasis0.62330773
60MP0004085_abnormal_heartbeat0.58168429
61MP0010329_abnormal_lipoprotein_level0.57638109
62MP0002928_abnormal_bile_duct0.57384461
63MP0008007_abnormal_cellular_replicative0.56998566
64MP0002572_abnormal_emotion/affect_behav0.55324439
65MP0000681_abnormal_thyroid_gland0.53962626
66MP0001666_abnormal_nutrient_absorption0.53838583
67MP0002102_abnormal_ear_morphology0.53646312
68MP0003950_abnormal_plasma_membrane0.53540955
69MP0000569_abnormal_digit_pigmentation0.52833113
70MP0000358_abnormal_cell_content/0.52000309
71MP0000049_abnormal_middle_ear0.51262116
72MP0003699_abnormal_female_reproductive0.51043121
73MP0005377_hearing/vestibular/ear_phenot0.50941218
74MP0003878_abnormal_ear_physiology0.50941218
75MP0003115_abnormal_respiratory_system0.50849742
76MP0002272_abnormal_nervous_system0.50377083
77MP0001440_abnormal_grooming_behavior0.50274784
78MP0001324_abnormal_eye_pigmentation0.49786840
79MP0005551_abnormal_eye_electrophysiolog0.47788969
80MP0003137_abnormal_impulse_conducting0.47589757
81MP0000230_abnormal_systemic_arterial0.46980426
82MP0004036_abnormal_muscle_relaxation0.46903221
83MP0000003_abnormal_adipose_tissue0.46341180
84MP0009745_abnormal_behavioral_response0.45955224
85MP0001270_distended_abdomen0.45629895
86MP0010307_abnormal_tumor_latency0.45453230
87MP0002733_abnormal_thermal_nociception0.44276815
88MP0004019_abnormal_vitamin_homeostasis0.44006186
89MP0005253_abnormal_eye_physiology0.43196897
90MP0001119_abnormal_female_reproductive0.43086974
91MP0002734_abnormal_mechanical_nocicepti0.43041350
92MP0004484_altered_response_of0.43031604
93MP0005367_renal/urinary_system_phenotyp0.42667044
94MP0000516_abnormal_urinary_system0.42667044
95MP0005397_hematopoietic_system_phenotyp0.42281003
96MP0001545_abnormal_hematopoietic_system0.42281003
97MP0005408_hypopigmentation0.42272114
98MP0001879_abnormal_lymphatic_vessel0.42104251
99MP0004134_abnormal_chest_morphology0.41346708
100MP0005535_abnormal_body_temperature0.41015522
101MP0001293_anophthalmia0.40675622
102MP0005666_abnormal_adipose_tissue0.40657485
103MP0005084_abnormal_gallbladder_morpholo0.40330682
104MP0001764_abnormal_homeostasis0.39785270
105MP0002269_muscular_atrophy0.37782484
106MP0000249_abnormal_blood_vessel0.36916336
107MP0005645_abnormal_hypothalamus_physiol0.36606177
108MP0005332_abnormal_amino_acid0.36005105
109MP0001501_abnormal_sleep_pattern0.35976673
110MP0003329_amyloid_beta_deposits0.35426526
111MP0002971_abnormal_brown_adipose0.35281079
112MP0003111_abnormal_nucleus_morphology0.35046260
113MP0006036_abnormal_mitochondrial_physio0.34877243
114MP0003633_abnormal_nervous_system0.33989164
115MP0004808_abnormal_hematopoietic_stem0.33531260
116MP0002139_abnormal_hepatobiliary_system0.32885349
117MP0005391_vision/eye_phenotype0.31950843
118MP0009115_abnormal_fat_cell0.31481947
119MP0009278_abnormal_bone_marrow0.29807686
120MP0001730_embryonic_growth_arrest0.28196383
121MP0004133_heterotaxia0.26446267
122MP0002736_abnormal_nociception_after0.24432151
123MP0003631_nervous_system_phenotype0.23456346
124MP0000313_abnormal_cell_death0.23225708
125MP0004811_abnormal_neuron_physiology0.22308773
126MP0003861_abnormal_nervous_system0.21860738
127MP0002152_abnormal_brain_morphology0.20868129
128MP0000427_abnormal_hair_cycle0.20710059
129MP0006035_abnormal_mitochondrial_morpho0.20240240
130MP0006072_abnormal_retinal_apoptosis0.19613146
131MP0001727_abnormal_embryo_implantation0.19473499
132MP0005365_abnormal_bile_salt0.17705337
133MP0000604_amyloidosis0.17493432
134MP0002084_abnormal_developmental_patter0.17442193
135MP0002132_abnormal_respiratory_system0.17234755
136MP0004084_abnormal_cardiac_muscle0.16978611
137MP0002169_no_abnormal_phenotype0.16049421
138MP0002873_normal_phenotype0.15798632
139MP0002229_neurodegeneration0.15629557
140MP0005195_abnormal_posterior_eye0.14987266
141MP0008875_abnormal_xenobiotic_pharmacok0.14918287
142MP0005319_abnormal_enzyme/_coenzyme0.14846543
143MP0002092_abnormal_eye_morphology0.14655071
144MP0003879_abnormal_hair_cell0.14426076
145MP0003077_abnormal_cell_cycle0.13216177
146MP0003948_abnormal_gas_homeostasis0.12802434
147MP0000534_abnormal_ureter_morphology0.12683490
148MP0003045_fibrosis0.12212446
149MP0004145_abnormal_muscle_electrophysio0.11928205
150MP0004043_abnormal_pH_regulation0.11742562
151MP0002405_respiratory_system_inflammati0.11639026
152MP0001968_abnormal_touch/_nociception0.11353964
153MP0005388_respiratory_system_phenotype0.11148292
154MP0002133_abnormal_respiratory_system0.11148292
155MP0000001_mammalian_phenotype0.11070361
156MP0000432_abnormal_head_morphology0.10957305
157MP0008961_abnormal_basal_metabolism0.10928117

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.62451308
2Abnormal respiratory motile cilium morphology (HP:0005938)9.19222473
3Abnormal respiratory epithelium morphology (HP:0012253)9.19222473
4Abnormal ciliary motility (HP:0012262)7.97679026
5Rhinitis (HP:0012384)7.78154485
6Chronic bronchitis (HP:0004469)7.51761867
7Severe visual impairment (HP:0001141)6.83765857
8Chronic hepatic failure (HP:0100626)6.71041073
9Nasal polyposis (HP:0100582)6.35435854
10Infertility (HP:0000789)6.22547570
11Abnormality of the nasal mucosa (HP:0000433)5.22762529
12Cone-rod dystrophy (HP:0000548)4.95053558
13Hyperkalemia (HP:0002153)4.94853630
14Resting tremor (HP:0002322)4.57845017
15Bronchitis (HP:0012387)4.49177682
16Bronchiectasis (HP:0002110)4.49120220
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.47952984
18Hypoalphalipoproteinemia (HP:0003233)4.31708182
19Abnormality of macular pigmentation (HP:0008002)4.28819690
20Nephronophthisis (HP:0000090)4.23767941
21Menstrual irregularities (HP:0000858)4.20626674
22Bony spicule pigmentary retinopathy (HP:0007737)4.14836069
23Attenuation of retinal blood vessels (HP:0007843)4.04836462
24Progressive sensorineural hearing impairment (HP:0000408)3.99765767
25Hypoplasia of the thymus (HP:0000778)3.83797063
26Male infertility (HP:0003251)3.82408723
27Recurrent sinusitis (HP:0011108)3.71084777
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.68270752
29Amelogenesis imperfecta (HP:0000705)3.64171746
30Renovascular hypertension (HP:0100817)3.62818395
31Truncal obesity (HP:0001956)3.34027573
32Insulin-resistant diabetes mellitus (HP:0000831)3.32905811
33Potter facies (HP:0002009)3.32893735
34Facial shape deformation (HP:0011334)3.32893735
35Abnormality of dental color (HP:0011073)3.26754176
36Recurrent otitis media (HP:0000403)3.24008037
37Abnormality of the renal medulla (HP:0100957)3.23072230
38Postural instability (HP:0002172)3.21437277
39Abnormal spermatogenesis (HP:0008669)3.20390835
40Portal hypertension (HP:0001409)3.18114159
41Progressive cerebellar ataxia (HP:0002073)3.06063904
42Medial flaring of the eyebrow (HP:0010747)2.95596240
43Abnormality of the hepatic vasculature (HP:0006707)2.92596058
44Tubulointerstitial nephritis (HP:0001970)2.91728169
45Subcapsular cataract (HP:0000523)2.78600595
46Increased purine levels (HP:0004368)2.75629579
47Hyperuricemia (HP:0002149)2.75629579
48Abnormal rod and cone electroretinograms (HP:0008323)2.74804588
49Abnormality of midbrain morphology (HP:0002418)2.72682670
50Molar tooth sign on MRI (HP:0002419)2.72682670
51Abnormality of the lower motor neuron (HP:0002366)2.67649049
52Abnormality of potassium homeostasis (HP:0011042)2.58324826
53Progressive hearing impairment (HP:0001730)2.57282183
54Tubular atrophy (HP:0000092)2.56488764
55Enlarged epiphyses (HP:0010580)2.53269069
56Abnormality of the costochondral junction (HP:0000919)2.51479209
57Gonadotropin excess (HP:0000837)2.47739792
58Recurrent bronchitis (HP:0002837)2.47454892
59Tubulointerstitial abnormality (HP:0001969)2.41351682
60Generalized aminoaciduria (HP:0002909)2.38537634
61Azoospermia (HP:0000027)2.31904063
62Intellectual disability, moderate (HP:0002342)2.29689250
63Myokymia (HP:0002411)2.29326068
64Hypoplastic ischia (HP:0003175)2.29242574
65Abnormality of the aortic arch (HP:0012303)2.23833883
66Focal segmental glomerulosclerosis (HP:0000097)2.23589360
67Hypolipoproteinemia (HP:0010981)2.21204243
68Ventricular tachycardia (HP:0004756)2.20193216
69Osteomalacia (HP:0002749)2.14969010
70Fibular hypoplasia (HP:0003038)2.14811388
71Recurrent pneumonia (HP:0006532)2.12011436
72Amyotrophic lateral sclerosis (HP:0007354)2.09714963
73Abnormality of the ischium (HP:0003174)2.09588713
74Unilateral renal agenesis (HP:0000122)2.07024799
75Impulsivity (HP:0100710)2.01430792
76Polyuria (HP:0000103)2.00475616
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5618561
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.2944163
79Absent/shortened dynein arms (HP:0200106)13.2944163
80Postaxial foot polydactyly (HP:0001830)1.98549666
81Congenital malformation of the right heart (HP:0011723)1.96725945
82Double outlet right ventricle (HP:0001719)1.96725945
83Hypophosphatemic rickets (HP:0004912)1.95800833
84Insulin resistance (HP:0000855)1.93458034
85Stage 5 chronic kidney disease (HP:0003774)1.87796025
86Tubulointerstitial fibrosis (HP:0005576)1.87577500
87Hyponatremia (HP:0002902)1.87218341
88Congenital primary aphakia (HP:0007707)1.85847713
89Gait imbalance (HP:0002141)1.85500840
90Renal Fanconi syndrome (HP:0001994)1.84234791
91Congenital hepatic fibrosis (HP:0002612)1.83881722
92Abnormality of purine metabolism (HP:0004352)1.83124329
93Gingivitis (HP:0000230)1.82861566
94Flattened epiphyses (HP:0003071)1.82709032
95Chronic sinusitis (HP:0011109)1.82563791
96Widely patent fontanelles and sutures (HP:0004492)1.81594846
97Abnormality of the renal cortex (HP:0011035)1.79683840
98Glomerulosclerosis (HP:0000096)1.78324787
99Bradycardia (HP:0001662)1.77836215
100Acanthosis nigricans (HP:0000956)1.76150906
101Optic nerve hypoplasia (HP:0000609)1.74646279
102Sandal gap (HP:0001852)1.73442445
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72462285
104Abnormal drinking behavior (HP:0030082)1.70367005
105Polydipsia (HP:0001959)1.70367005
106Abnormality of the dental root (HP:0006486)1.70121343
107Taurodontia (HP:0000679)1.70121343
108Abnormality of permanent molar morphology (HP:0011071)1.70121343
109Upper limb muscle weakness (HP:0003484)1.70026664
110Obsessive-compulsive behavior (HP:0000722)1.69411382
111Abnormality of chloride homeostasis (HP:0011422)1.69382539
112Abnormality of the parathyroid morphology (HP:0011766)1.68824255
113Oculomotor apraxia (HP:0000657)1.68645230
114Photophobia (HP:0000613)1.65601935
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65188935
116Microglossia (HP:0000171)1.64859384
117Polar cataract (HP:0010696)1.64798022
118Short ribs (HP:0000773)1.63278513
119Occipital encephalocele (HP:0002085)1.63232002
120Postaxial hand polydactyly (HP:0001162)1.62718577
121Hypoalbuminemia (HP:0003073)1.62684891
122Impaired proprioception (HP:0010831)1.62665615
123Abnormality of renal excretion (HP:0011036)1.60662764
124Abnormality of molar morphology (HP:0011070)1.58864227
125Abnormality of molar (HP:0011077)1.58864227
126Nephrogenic diabetes insipidus (HP:0009806)1.58602061
127Absent frontal sinuses (HP:0002688)1.58453586
128Facial cleft (HP:0002006)1.56473312
129Dyschromatopsia (HP:0007641)1.55499201
130Abnormality of the dental pulp (HP:0006479)1.55033158
131Abnormal gallbladder physiology (HP:0012438)1.54956082
132Cholecystitis (HP:0001082)1.54956082
133Renal dysplasia (HP:0000110)1.54608027
134Supernumerary spleens (HP:0009799)1.53137527
135Pancreatic fibrosis (HP:0100732)1.53050302
136Abnormality of dentin (HP:0010299)1.50048933
137Heterotopia (HP:0002282)1.49670834
138Aplasia/Hypoplasia of the lens (HP:0008063)1.49035447
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.47830538
140Decreased central vision (HP:0007663)1.46213019
141Cystic liver disease (HP:0006706)1.45963512
142J-shaped sella turcica (HP:0002680)1.45583363
143Upper motor neuron abnormality (HP:0002127)1.45528593
144Spastic tetraparesis (HP:0001285)1.45051950
145Abnormality of ocular smooth pursuit (HP:0000617)1.40536638
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.40004145
147Bile duct proliferation (HP:0001408)1.39409034
148Abnormal biliary tract physiology (HP:0012439)1.39409034
149Poor coordination (HP:0002370)1.38955566
150Genital tract atresia (HP:0001827)1.38738017
151Vaginal atresia (HP:0000148)1.37134307
152Abnormality of saccadic eye movements (HP:0000570)1.36686416
153Asymmetric septal hypertrophy (HP:0001670)1.36165567
154Median cleft lip (HP:0000161)1.35212290
155Aplasia/Hypoplasia of the fibula (HP:0006492)1.35044190
156Bell-shaped thorax (HP:0001591)1.33703004
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.29382152
158Absent epiphyses (HP:0010577)1.29382152
159Breast carcinoma (HP:0003002)1.28827127
160Tongue fasciculations (HP:0001308)1.27965366
161True hermaphroditism (HP:0010459)1.25710416
162Degeneration of anterior horn cells (HP:0002398)1.24787605
163Abnormality of the anterior horn cell (HP:0006802)1.24787605
164Deformed sella turcica (HP:0002681)1.24125125
165Vascular calcification (HP:0004934)1.23894411
166Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23622792
167Short thorax (HP:0010306)1.23328688
16811 pairs of ribs (HP:0000878)1.21831124
169Nephropathy (HP:0000112)1.20623168
170Abnormal urine output (HP:0012590)1.20360169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.60068497
2PDK49.60068497
3PDK26.24952738
4BRD44.30120764
5TESK14.08633288
6INSRR3.98851903
7PLK23.60004648
8PRKD33.35036419
9DDR23.09417373
10ICK2.96378958
11MAP4K22.46293271
12PIK3CG2.26080316
13PTK2B2.20119428
14WNK42.08247288
15STK392.01550937
16PNCK1.88591162
17MST1R1.55554161
18NEK21.50540081
19STK381.23077182
20AKT31.12331154
21CAMK1D1.06384759
22PDK11.02832806
23DYRK1B0.94916846
24CDK70.94451386
25SIK20.92270510
26TYRO30.84111433
27WNK10.83886500
28MAP3K110.79687018
29KSR20.78143161
30IRAK10.77488009
31LMTK20.77408116
32CCNB10.75204868
33MAPK150.74399210
34PASK0.73354551
35STK30.70072931
36TIE10.66104675
37DYRK30.65165341
38CAMK10.58593866
39SGK4940.56926343
40SGK2230.56926343
41CDC70.56654729
42TTK0.55984686
43MAP2K20.55793132
44PLK40.55557616
45RPS6KA20.55363779
46CHEK20.53777722
47WEE10.53665857
48MARK10.52137796
49MAP3K90.51298895
50MAP3K20.50027831
51MAP2K60.48822498
52LATS20.48567419
53UHMK10.48516473
54LATS10.45064039
55CDK30.44898750
56CHEK10.44632917
57PINK10.43760652
58STK38L0.43417803
59PDPK10.42734700
60CAMK1G0.41745379
61TESK20.41264771
62PRKAA20.40741569
63MAPK10.39675195
64ROCK10.39468590
65ATR0.36643351
66CAMK40.35803099
67MAP3K10.35555793
68SGK10.33857539
69MAP3K80.31839517
70CDK120.31228479
71IRAK20.30668919
72EEF2K0.30469259
73RIPK40.30151850
74ATM0.29818771
75BRSK20.29802548
76NTRK30.29065321
77PAK10.26980105
78JAK30.24542253
79SGK20.24460129
80MUSK0.24343335
81NTRK20.23006231
82PRKCG0.22936218
83RPS6KL10.22729093
84RPS6KC10.22729093
85MAPK140.22357235
86MTOR0.19710970
87PLK10.19688208
88RPS6KA60.19436206
89PAK20.19389240
90NEK60.17015811
91CAMKK10.16706966
92PRKAA10.15383751
93MET0.15077871
94RPS6KB10.14774907
95CDK40.14673306
96MAPKAPK50.14173855
97OXSR10.13293991
98MAPK110.12591951
99AKT10.12474255
100ARAF0.11507025
101BLK0.11505318
102SGK30.11074291
103MARK20.10701244
104MAP3K100.10639609
105MARK30.10299838
106WNK30.08789103
107FER0.08186467
108PRKCZ0.07973952
109BRSK10.07656097
110PRKG20.07372683
111PRKCQ0.07174260
112PRKG10.06840624
113MAPK90.06613215
114CSNK2A10.06303288
115MAP3K40.06274217
116CSNK1D0.05899004
117MINK10.05765533
118PKN10.05700896
119PRKACG0.05546973
120CDK150.05402044
121ZAP700.05317165
122MAP2K70.05127102
123RIPK10.05113863
124BRAF0.03993159
125YES10.03881356
126TNIK0.03789234
127CDK10.03759020
128CSNK2A20.03685861
129GSK3B0.03601530
130CDK20.03470817
131CDK180.03203736
132PDGFRB0.02486967
133CDK11A0.02281636
134MAPK80.02145121
135STK100.01442954
136PRKDC0.01441446
137EGFR0.01367201
138BMPR1B0.00987730
139RPS6KA10.00876432
140PRKACB0.00565814
141CSF1R0.00333970
142CDK140.00308982
143PRKCB0.00142149
144PRKACA-0.0348130
145CDK6-0.0248582
146MAPK10-0.0224178
147RPS6KA3-0.0179317
148PAK4-0.0170613
149PRKCA-0.0168433
150CAMK2A-0.0134436
151MAP3K5-0.0105728
152STK11-0.0049943

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.96777527
2Vitamin B6 metabolism_Homo sapiens_hsa007504.88683442
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.48441788
4Pyruvate metabolism_Homo sapiens_hsa006204.26763202
5Olfactory transduction_Homo sapiens_hsa047403.55877355
6Fatty acid biosynthesis_Homo sapiens_hsa000613.46100667
7Propanoate metabolism_Homo sapiens_hsa006403.41562355
8Glucagon signaling pathway_Homo sapiens_hsa049222.80309287
9Basal transcription factors_Homo sapiens_hsa030222.66926873
10Pentose phosphate pathway_Homo sapiens_hsa000302.56523121
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41295975
12Selenocompound metabolism_Homo sapiens_hsa004502.35966184
13Linoleic acid metabolism_Homo sapiens_hsa005912.32864021
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.20935692
15Butanoate metabolism_Homo sapiens_hsa006502.08300168
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.07501290
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04878526
18Oocyte meiosis_Homo sapiens_hsa041141.97338447
19Glycerolipid metabolism_Homo sapiens_hsa005611.95652110
20Fanconi anemia pathway_Homo sapiens_hsa034601.94857142
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83996338
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.79987425
23Dorso-ventral axis formation_Homo sapiens_hsa043201.76412095
24PPAR signaling pathway_Homo sapiens_hsa033201.69857054
25Phenylalanine metabolism_Homo sapiens_hsa003601.62891866
26Carbon metabolism_Homo sapiens_hsa012001.57475961
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.52225706
28Type II diabetes mellitus_Homo sapiens_hsa049301.51974066
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46720986
30Huntingtons disease_Homo sapiens_hsa050161.46432441
31Amphetamine addiction_Homo sapiens_hsa050311.43844022
32Fructose and mannose metabolism_Homo sapiens_hsa000511.32146509
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.31463516
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24064554
35Renin secretion_Homo sapiens_hsa049241.24009130
36Cardiac muscle contraction_Homo sapiens_hsa042601.22399265
37Mineral absorption_Homo sapiens_hsa049781.21924053
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21634569
39Phototransduction_Homo sapiens_hsa047441.19717762
40Biosynthesis of amino acids_Homo sapiens_hsa012301.12732583
41Fat digestion and absorption_Homo sapiens_hsa049751.09922229
42mRNA surveillance pathway_Homo sapiens_hsa030151.09160341
43Antigen processing and presentation_Homo sapiens_hsa046121.08159657
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04548369
45Morphine addiction_Homo sapiens_hsa050321.03804477
46RNA transport_Homo sapiens_hsa030131.02908793
47Purine metabolism_Homo sapiens_hsa002301.02246684
48Ether lipid metabolism_Homo sapiens_hsa005651.02231661
49Fatty acid metabolism_Homo sapiens_hsa012121.02051509
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.01896871
51Fatty acid degradation_Homo sapiens_hsa000710.99674034
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96729424
53Nicotine addiction_Homo sapiens_hsa050330.95716007
54Arginine biosynthesis_Homo sapiens_hsa002200.94143686
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91897307
56Type I diabetes mellitus_Homo sapiens_hsa049400.89915810
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84587467
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84050892
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82518705
60Glutathione metabolism_Homo sapiens_hsa004800.81476294
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80983359
62Glutamatergic synapse_Homo sapiens_hsa047240.80838093
63Arginine and proline metabolism_Homo sapiens_hsa003300.79880655
64Long-term potentiation_Homo sapiens_hsa047200.73644855
65Renin-angiotensin system_Homo sapiens_hsa046140.72879323
66Collecting duct acid secretion_Homo sapiens_hsa049660.72807279
67Chemical carcinogenesis_Homo sapiens_hsa052040.72131791
68Influenza A_Homo sapiens_hsa051640.71470383
69Tyrosine metabolism_Homo sapiens_hsa003500.71389647
70ABC transporters_Homo sapiens_hsa020100.70663436
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69297145
72Estrogen signaling pathway_Homo sapiens_hsa049150.63412998
73Serotonergic synapse_Homo sapiens_hsa047260.62031765
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.61147361
75Calcium signaling pathway_Homo sapiens_hsa040200.59707784
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58112650
77Viral myocarditis_Homo sapiens_hsa054160.57931088
78Bile secretion_Homo sapiens_hsa049760.57878683
79Autoimmune thyroid disease_Homo sapiens_hsa053200.57755154
80Inositol phosphate metabolism_Homo sapiens_hsa005620.57530528
81Insulin secretion_Homo sapiens_hsa049110.57492818
82Allograft rejection_Homo sapiens_hsa053300.55793893
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55663028
84Thyroid hormone synthesis_Homo sapiens_hsa049180.54483046
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53542674
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53332743
87Systemic lupus erythematosus_Homo sapiens_hsa053220.50392480
88GABAergic synapse_Homo sapiens_hsa047270.50168554
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.50099832
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49638284
91N-Glycan biosynthesis_Homo sapiens_hsa005100.49356136
92Legionellosis_Homo sapiens_hsa051340.49352560
93Arachidonic acid metabolism_Homo sapiens_hsa005900.49208392
94Tight junction_Homo sapiens_hsa045300.49023442
95Nitrogen metabolism_Homo sapiens_hsa009100.48079344
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.44653060
97Graft-versus-host disease_Homo sapiens_hsa053320.43808116
98Metabolic pathways_Homo sapiens_hsa011000.42049589
99MAPK signaling pathway_Homo sapiens_hsa040100.41801431
100Hedgehog signaling pathway_Homo sapiens_hsa043400.40650071
101Protein digestion and absorption_Homo sapiens_hsa049740.39893141
102AMPK signaling pathway_Homo sapiens_hsa041520.37681961
103Cholinergic synapse_Homo sapiens_hsa047250.37381689
104VEGF signaling pathway_Homo sapiens_hsa043700.37236090
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37133911
106Taste transduction_Homo sapiens_hsa047420.36897173
107Synaptic vesicle cycle_Homo sapiens_hsa047210.36538425
108Pancreatic secretion_Homo sapiens_hsa049720.36000813
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35367185
110Endocytosis_Homo sapiens_hsa041440.35010965
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32503808
112Acute myeloid leukemia_Homo sapiens_hsa052210.31910589
113Sulfur metabolism_Homo sapiens_hsa009200.31503568
114Salivary secretion_Homo sapiens_hsa049700.31249965
115Gastric acid secretion_Homo sapiens_hsa049710.28777032
116Oxytocin signaling pathway_Homo sapiens_hsa049210.27795600
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25940621
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25828775
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25479723
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25036142
121Circadian entrainment_Homo sapiens_hsa047130.24371647
122ECM-receptor interaction_Homo sapiens_hsa045120.24198197
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.22630991
124cAMP signaling pathway_Homo sapiens_hsa040240.22486103
125Homologous recombination_Homo sapiens_hsa034400.19426941
126Pyrimidine metabolism_Homo sapiens_hsa002400.18922404
127mTOR signaling pathway_Homo sapiens_hsa041500.18781095
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18341830
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.17637310
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17098266
131Prolactin signaling pathway_Homo sapiens_hsa049170.16331771
132Adherens junction_Homo sapiens_hsa045200.15834695
133B cell receptor signaling pathway_Homo sapiens_hsa046620.15709158
134Cell cycle_Homo sapiens_hsa041100.14325484
135Retinol metabolism_Homo sapiens_hsa008300.13327942
136Wnt signaling pathway_Homo sapiens_hsa043100.11814048
137Alcoholism_Homo sapiens_hsa050340.10619367
138Viral carcinogenesis_Homo sapiens_hsa052030.09571317
139RNA degradation_Homo sapiens_hsa030180.09530551
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.08496371

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