CRH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of catecholamine secretion (GO:0033605)9.80448112
2germ cell migration (GO:0008354)8.70089188
3* positive regulation of calcium ion import (GO:0090280)7.38978168
4positive regulation of monocyte chemotaxis (GO:0090026)7.21109771
5vocalization behavior (GO:0071625)7.10230349
6protein neddylation (GO:0045116)6.55036848
7startle response (GO:0001964)6.43674664
8regulation of axon extension involved in axon guidance (GO:0048841)6.42095006
9substrate-independent telencephalic tangential migration (GO:0021826)6.14098361
10substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.14098361
11regulation of dopamine secretion (GO:0014059)6.10958483
12regulation of cellular extravasation (GO:0002691)6.01855778
13positive regulation of odontogenesis (GO:0042482)5.93190593
14neuron cell-cell adhesion (GO:0007158)5.88016214
15regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86067834
16regulation of axon guidance (GO:1902667)5.74024751
17induction of positive chemotaxis (GO:0050930)5.43985191
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.37617316
19succinate metabolic process (GO:0006105)5.35120957
20regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.11743372
21RNA destabilization (GO:0050779)5.11251156
22synaptic vesicle exocytosis (GO:0016079)4.91633169
23tooth mineralization (GO:0034505)4.88160408
24regulation of monocyte chemotaxis (GO:0090025)4.87306563
25neuronal ion channel clustering (GO:0045161)4.85153910
26positive regulation of amine transport (GO:0051954)4.83909679
27somite development (GO:0061053)4.81710813
28gamma-aminobutyric acid transport (GO:0015812)4.65946453
29response to histamine (GO:0034776)4.64567058
30energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62417409
31ATP synthesis coupled proton transport (GO:0015986)4.62417409
32neuronal action potential propagation (GO:0019227)4.61336761
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60326470
34gamma-aminobutyric acid signaling pathway (GO:0007214)4.56009387
35regulation of cilium movement (GO:0003352)4.49782995
36neurotransmitter secretion (GO:0007269)4.47181383
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.44090699
38regulation of sensory perception (GO:0051931)4.42008673
39regulation of sensory perception of pain (GO:0051930)4.42008673
40positive regulation of synapse maturation (GO:0090129)4.41968520
41mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.35413733
42motor neuron axon guidance (GO:0008045)4.34302589
43* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28218607
44* neuron-neuron synaptic transmission (GO:0007270)4.23843029
45negative regulation of potassium ion transport (GO:0043267)4.23479173
46negative regulation of leukocyte migration (GO:0002686)4.23367469
47positive regulation of axon extension (GO:0045773)4.20769513
48* regulation of glutamate receptor signaling pathway (GO:1900449)4.20255631
49* regulation of calcium ion import (GO:0090279)4.13312550
50glutathione biosynthetic process (GO:0006750)4.12079668
51neurofilament cytoskeleton organization (GO:0060052)4.10879678
52negative regulation of synaptic transmission, GABAergic (GO:0032229)4.09508515
53ionotropic glutamate receptor signaling pathway (GO:0035235)4.06026333
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.05886509
55negative regulation of translation, ncRNA-mediated (GO:0040033)4.05886509
56regulation of translation, ncRNA-mediated (GO:0045974)4.05886509
57regulation of monocyte differentiation (GO:0045655)4.04653969
58maternal behavior (GO:0042711)4.02408404
59cell migration in hindbrain (GO:0021535)3.97734215
60positive regulation of synapse assembly (GO:0051965)3.91586224
61positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.86537283
62energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.84975781
63ATP hydrolysis coupled proton transport (GO:0015991)3.84975781
64regulation of synapse maturation (GO:0090128)3.83966531
65neuron recognition (GO:0008038)3.83265387
66nonribosomal peptide biosynthetic process (GO:0019184)3.82206222
67synaptic transmission, glutamatergic (GO:0035249)3.77430494
68transmission of nerve impulse (GO:0019226)3.76671878
69glutamate secretion (GO:0014047)3.76247469
70presynaptic membrane assembly (GO:0097105)3.72528235
71glutamate receptor signaling pathway (GO:0007215)3.63593534
72negative regulation of dendrite morphogenesis (GO:0050774)3.63453335
73regulation of synaptic vesicle exocytosis (GO:2000300)3.62414693
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61206629
75protein polyglutamylation (GO:0018095)3.59032002
76glycerophospholipid catabolic process (GO:0046475)3.58799107
77telencephalon cell migration (GO:0022029)3.58377038
78body morphogenesis (GO:0010171)3.56733782
79protein localization to synapse (GO:0035418)3.53238732
80positive regulation of cardiac muscle hypertrophy (GO:0010613)3.53019924
81positive regulation of muscle hypertrophy (GO:0014742)3.53019924
82synaptic vesicle maturation (GO:0016188)3.50950434
83positive regulation of growth hormone secretion (GO:0060124)3.46677419
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45858238
85gonadal mesoderm development (GO:0007506)3.45009475
86neurotransmitter transport (GO:0006836)3.44652525
87response to follicle-stimulating hormone (GO:0032354)3.44319988
88forebrain cell migration (GO:0021885)3.42218846
89parental behavior (GO:0060746)3.39832240
90convergent extension (GO:0060026)3.39831730
91respiratory electron transport chain (GO:0022904)3.37697622
92transferrin transport (GO:0033572)3.37004084
93L-serine transport (GO:0015825)3.35991270
94embryonic body morphogenesis (GO:0010172)3.34012942
95multicellular organismal reproductive behavior (GO:0033057)3.32758905
96* regulation of catecholamine secretion (GO:0050433)3.32353722
97neurotransmitter-gated ion channel clustering (GO:0072578)3.28974792
98alanine transport (GO:0032328)3.28471935
99electron transport chain (GO:0022900)3.27760781
100intraspecies interaction between organisms (GO:0051703)3.25092845
101social behavior (GO:0035176)3.25092845
102estrogen biosynthetic process (GO:0006703)3.24615686
103behavioral response to nicotine (GO:0035095)3.22108330
104ferric iron transport (GO:0015682)3.20337299
105trivalent inorganic cation transport (GO:0072512)3.20337299
106sequestering of extracellular ligand from receptor (GO:0035581)3.19683244
107regulation of neurotransmitter levels (GO:0001505)3.16906288
108adrenergic receptor signaling pathway (GO:0071875)3.16508352
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15583708
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15036168
111postsynaptic membrane organization (GO:0001941)3.14685644
112positive regulation of T cell migration (GO:2000406)3.13140247
113multi-organism reproductive behavior (GO:0044705)3.11662075
114presynaptic membrane organization (GO:0097090)3.11065064
115regulation of microtubule-based movement (GO:0060632)3.09922413
116regulation of synapse assembly (GO:0051963)3.09314404
117regulation of synaptic vesicle transport (GO:1902803)3.09087073
118regulation of synaptic transmission, glutamatergic (GO:0051966)3.08886873
119microtubule severing (GO:0051013)3.08867450
120CDP-diacylglycerol metabolic process (GO:0046341)3.07631872
121reproductive behavior (GO:0019098)3.07583385
122dicarboxylic acid catabolic process (GO:0043649)3.06873360
123negative regulation of neurotransmitter secretion (GO:0046929)3.06747180
124synapse assembly (GO:0007416)3.05145259
125negative regulation of gluconeogenesis (GO:0045721)3.04752133
126positive regulation of potassium ion transmembrane transport (GO:1901381)3.04653700
127positive regulation of positive chemotaxis (GO:0050927)3.04087180
128axon ensheathment in central nervous system (GO:0032291)3.03648064
129central nervous system myelination (GO:0022010)3.03648064
130positive regulation of vesicle fusion (GO:0031340)3.02306220
131positive regulation of action potential (GO:0045760)3.01756493
132cerebellar granule cell differentiation (GO:0021707)3.01219810
133regulation of protein kinase A signaling (GO:0010738)2.98566367
134female mating behavior (GO:0060180)2.97841597
135* locomotory exploration behavior (GO:0035641)2.97712756
136detection of calcium ion (GO:0005513)2.96744598
137multi-organism behavior (GO:0051705)2.96582881
138neurotransmitter biosynthetic process (GO:0042136)2.96563217
139regulation of positive chemotaxis (GO:0050926)2.96407113
140regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96230895
141positive regulation of adenylate cyclase activity (GO:0045762)2.95875089
142negative regulation of dendrite development (GO:2000171)2.95523020
143regulation of glutamate secretion (GO:0014048)2.95133197
144complement activation, alternative pathway (GO:0006957)2.94378877
145estrogen metabolic process (GO:0008210)2.94193764
146regulation of axon extension (GO:0030516)2.93936981
147regulation of neuronal synaptic plasticity (GO:0048168)2.92925093
148phosphorylated carbohydrate dephosphorylation (GO:0046838)2.92001497
149inositol phosphate dephosphorylation (GO:0046855)2.92001497
150activation of protein kinase A activity (GO:0034199)2.91768750
151* parturition (GO:0007567)2.91299446
152axonal fasciculation (GO:0007413)2.90969070
153regulation of vesicle fusion (GO:0031338)2.89200073
154receptor recycling (GO:0001881)2.88172096
155toxin metabolic process (GO:0009404)2.87021608
156brain morphogenesis (GO:0048854)2.85050119
157serine transport (GO:0032329)2.84247913
158positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83822292
159* negative regulation of catecholamine secretion (GO:0033604)2.83489915
160peptide biosynthetic process (GO:0043043)2.82980970
161thalamus development (GO:0021794)2.82523530
162regulation of action potential (GO:0098900)2.82450252
163striatum development (GO:0021756)2.81938708
164negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81509871
165regulation of long-term neuronal synaptic plasticity (GO:0048169)2.81199772
166tachykinin receptor signaling pathway (GO:0007217)2.81068868
167* negative regulation of amine transport (GO:0051953)2.80363540
168* cellular response to ammonium ion (GO:0071242)2.79836007
169cellular potassium ion homeostasis (GO:0030007)2.79642947
170positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.79152299
171establishment of melanosome localization (GO:0032401)2.79017658
172neuron migration (GO:0001764)2.78155158
173regulation of potassium ion transport (GO:0043266)2.78138822
174inositol phosphate catabolic process (GO:0071545)2.78006655
175regulation of synapse structural plasticity (GO:0051823)2.77896069
176regulation of non-canonical Wnt signaling pathway (GO:2000050)2.72368658
177CDP-diacylglycerol biosynthetic process (GO:0016024)2.72030053
178establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69785483
179mitochondrion transport along microtubule (GO:0047497)2.69785483
180establishment of mitochondrion localization (GO:0051654)2.69038988
181positive regulation of axonogenesis (GO:0050772)2.68133922
182response to gravity (GO:0009629)2.64858631
183establishment of pigment granule localization (GO:0051905)2.64124016
184short-term memory (GO:0007614)2.62401551
185cartilage condensation (GO:0001502)2.61580843
186cell aggregation (GO:0098743)2.61580843
187retinal rod cell development (GO:0046548)2.61127390
188behavioral response to ethanol (GO:0048149)2.59928325
189forebrain neuron differentiation (GO:0021879)2.59042231
190negative regulation of hormone biosynthetic process (GO:0032353)2.57481236
191melanosome transport (GO:0032402)2.57278640
192positive regulation of glomerulus development (GO:0090193)2.56854352
193regulation of T cell migration (GO:2000404)2.55016757
194regulation of penile erection (GO:0060405)10.2183818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.58237832
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.51452404
3GBX2_23144817_ChIP-Seq_PC3_Human3.83305463
4TAF15_26573619_Chip-Seq_HEK293_Human3.42549414
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21784137
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04427567
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02222957
8JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01273474
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64462634
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56830100
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54288283
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48583032
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.47707950
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.43748591
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43140824
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40202900
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37245207
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37245207
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35719166
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.34678722
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33722819
22FUS_26573619_Chip-Seq_HEK293_Human2.32273075
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26622615
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.24396362
25* REST_21632747_ChIP-Seq_MESCs_Mouse2.23355499
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05985505
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04974054
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99316538
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.94816551
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.92871786
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91024790
32P300_19829295_ChIP-Seq_ESCs_Human1.83858627
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.82662194
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.75262244
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68413812
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.68231612
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66951982
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60696847
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.60105169
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59097223
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.54399741
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53872581
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51547722
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50059898
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46427457
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.44671381
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43566476
48* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42821864
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40975087
50VDR_22108803_ChIP-Seq_LS180_Human1.40358542
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.39204419
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.39024624
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.38289825
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37758855
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36266732
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36015888
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35912033
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.35132692
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34966577
60DROSHA_22980978_ChIP-Seq_HELA_Human1.33751563
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33633097
62ZNF274_21170338_ChIP-Seq_K562_Hela1.33405841
63CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31817823
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31628996
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28768942
66AR_25329375_ChIP-Seq_VCAP_Human1.27730917
67ER_23166858_ChIP-Seq_MCF-7_Human1.26854386
68IGF1R_20145208_ChIP-Seq_DFB_Human1.26469928
69AR_21572438_ChIP-Seq_LNCaP_Human1.25328133
70* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24853878
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24092815
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24092815
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23021494
74BCAT_22108803_ChIP-Seq_LS180_Human1.22222238
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15481108
76* TCF4_23295773_ChIP-Seq_U87_Human1.15347762
77HTT_18923047_ChIP-ChIP_STHdh_Human1.14826614
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13156200
79RNF2_27304074_Chip-Seq_NSC_Mouse1.12842664
80* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12100047
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11971056
82AHR_22903824_ChIP-Seq_MCF-7_Human1.11623534
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11178099
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09946666
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.09422762
86CTCF_27219007_Chip-Seq_Bcells_Human1.06301675
87* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06207652
88RUNX2_22187159_ChIP-Seq_PCA_Human1.04851292
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03376841
90JUN_21703547_ChIP-Seq_K562_Human1.01332307
91KDM2B_26808549_Chip-Seq_K562_Human1.01299704
92* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01206142
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.01094865
94IRF1_19129219_ChIP-ChIP_H3396_Human1.00512059
95* RING1B_27294783_Chip-Seq_ESCs_Mouse1.00505670
96RXR_22108803_ChIP-Seq_LS180_Human1.00468824
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98824766
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97485538
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97449917
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96687284
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96468656
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96230324
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96009123
104CBP_20019798_ChIP-Seq_JUKART_Human0.96009123
105KDM2B_26808549_Chip-Seq_REH_Human0.94865066
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94023935
107TAL1_26923725_Chip-Seq_HPCs_Mouse0.93721044
108TP53_18474530_ChIP-ChIP_U2OS_Human0.93664296
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92495853
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92399518
111AR_19668381_ChIP-Seq_PC3_Human0.92236167
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.91866896
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91810589
114TCF4_22108803_ChIP-Seq_LS180_Human0.91708880
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91636194
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90832954
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90156366
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89897726
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89703356
120* STAT3_18555785_Chip-Seq_ESCs_Mouse0.89156413
121ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87014689
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84581159
123TP53_22573176_ChIP-Seq_HFKS_Human0.84524678
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84372415
125* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83796484
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83359622
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83345283
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82140289
129* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80963989
130* FOXA1_25329375_ChIP-Seq_VCAP_Human0.80963989
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79600651
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79180648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow5.83960528
2MP0003880_abnormal_central_pattern5.07330107
3MP0004859_abnormal_synaptic_plasticity4.35072402
4MP0002837_dystrophic_cardiac_calcinosis3.69633392
5MP0009046_muscle_twitch3.64810092
6MP0003635_abnormal_synaptic_transmissio3.51682601
7MP0009745_abnormal_behavioral_response3.48109092
8MP0002064_seizures3.32440696
9MP0001919_abnormal_reproductive_system3.30778054
10MP0002822_catalepsy2.87369155
11MP0002063_abnormal_learning/memory/cond2.70863045
12MP0002735_abnormal_chemical_nociception2.69545514
13MP0001188_hyperpigmentation2.67311173
14MP0002572_abnormal_emotion/affect_behav2.57583265
15MP0005423_abnormal_somatic_nervous2.55732163
16MP0002272_abnormal_nervous_system2.46158179
17MP0001486_abnormal_startle_reflex2.42888660
18MP0002734_abnormal_mechanical_nocicepti2.42139292
19MP0001545_abnormal_hematopoietic_system2.33784136
20MP0005397_hematopoietic_system_phenotyp2.33784136
21MP0001968_abnormal_touch/_nociception2.31092563
22MP0000013_abnormal_adipose_tissue2.30293291
23MP0005389_reproductive_system_phenotype2.09085926
24MP0009780_abnormal_chondrocyte_physiolo2.08460885
25MP0002184_abnormal_innervation2.07517964
26MP0003011_delayed_dark_adaptation2.03085591
27MP0001440_abnormal_grooming_behavior2.01783014
28MP0006292_abnormal_olfactory_placode1.98588166
29MP0002736_abnormal_nociception_after1.97922116
30MP0004142_abnormal_muscle_tone1.96431031
31MP0005187_abnormal_penis_morphology1.95797533
32MP0002876_abnormal_thyroid_physiology1.93106832
33MP0003329_amyloid_beta_deposits1.92258061
34MP0004885_abnormal_endolymph1.91647686
35MP0002653_abnormal_ependyma_morphology1.83087165
36MP0001501_abnormal_sleep_pattern1.82825129
37MP0002067_abnormal_sensory_capabilities1.82310706
38MP0004270_analgesia1.78085372
39MP0001970_abnormal_pain_threshold1.77402444
40MP0002733_abnormal_thermal_nociception1.77132926
41MP0003122_maternal_imprinting1.76322895
42MP0005647_abnormal_sex_gland1.74157743
43MP0006276_abnormal_autonomic_nervous1.74104185
44MP0005646_abnormal_pituitary_gland1.73308069
45MP0004147_increased_porphyrin_level1.66385214
46MP0002557_abnormal_social/conspecific_i1.61121081
47MP0008775_abnormal_heart_ventricle1.57203875
48MP0001529_abnormal_vocalization1.56739976
49MP0008569_lethality_at_weaning1.55294831
50MP0004085_abnormal_heartbeat1.45510771
51MP0001502_abnormal_circadian_rhythm1.43074234
52MP0010386_abnormal_urinary_bladder1.42153970
53MP0004924_abnormal_behavior1.40947112
54MP0005386_behavior/neurological_phenoty1.40947112
55MP0004215_abnormal_myocardial_fiber1.33863235
56MP0002066_abnormal_motor_capabilities/c1.28229126
57MP0003121_genomic_imprinting1.27956674
58MP0005379_endocrine/exocrine_gland_phen1.27528523
59MP0000751_myopathy1.25750270
60MP0002638_abnormal_pupillary_reflex1.20977583
61MP0002909_abnormal_adrenal_gland1.19907547
62MP0005623_abnormal_meninges_morphology1.19255524
63MP0001177_atelectasis1.19160705
64MP0001348_abnormal_lacrimal_gland1.16407310
65MP0000778_abnormal_nervous_system1.14681172
66MP0002254_reproductive_system_inflammat1.14210998
67MP0001727_abnormal_embryo_implantation1.12922486
68MP0010329_abnormal_lipoprotein_level1.11456117
69MP0002882_abnormal_neuron_morphology1.08713180
70MP0004811_abnormal_neuron_physiology1.08490885
71MP0000631_abnormal_neuroendocrine_gland1.06729314
72MP0008789_abnormal_olfactory_epithelium1.05823902
73MP0000955_abnormal_spinal_cord1.05172016
74MP0001963_abnormal_hearing_physiology1.04478481
75MP0003959_abnormal_lean_body1.03712350
76MP0002090_abnormal_vision1.03492668
77MP0001944_abnormal_pancreas_morphology1.03325608
78MP0008872_abnormal_physiological_respon1.02587409
79MP0002102_abnormal_ear_morphology1.01087105
80MP0008875_abnormal_xenobiotic_pharmacok1.00626230
81MP0000604_amyloidosis0.98312393
82MP0004858_abnormal_nervous_system0.98241944
83MP0002332_abnormal_exercise_endurance0.97158623
84MP0004484_altered_response_of0.95943284
85MP0008874_decreased_physiological_sensi0.95090361
86MP0001661_extended_life_span0.94070662
87MP0002163_abnormal_gland_morphology0.93474995
88MP0004019_abnormal_vitamin_homeostasis0.92957228
89MP0001756_abnormal_urination0.92446599
90MP0005551_abnormal_eye_electrophysiolog0.92340578
91MP0002127_abnormal_cardiovascular_syste0.92289818
92MP0004808_abnormal_hematopoietic_stem0.91409845
93MP0004134_abnormal_chest_morphology0.91356942
94MP0003646_muscle_fatigue0.91345140
95MP0003638_abnormal_response/metabolism_0.89923636
96MP0000003_abnormal_adipose_tissue0.89881593
97* MP0000639_abnormal_adrenal_gland0.89544556
98MP0003632_abnormal_nervous_system0.89539683
99MP0005503_abnormal_tendon_morphology0.88751484
100MP0003787_abnormal_imprinting0.88389204
101MP0000647_abnormal_sebaceous_gland0.87887117
102MP0003879_abnormal_hair_cell0.87644430
103MP0003137_abnormal_impulse_conducting0.87623285
104MP0005220_abnormal_exocrine_pancreas0.87217125
105MP0005499_abnormal_olfactory_system0.86201111
106MP0005394_taste/olfaction_phenotype0.86201111
107MP0005253_abnormal_eye_physiology0.85977705
108MP0009379_abnormal_foot_pigmentation0.85936677
109MP0005535_abnormal_body_temperature0.85288369
110MP0000681_abnormal_thyroid_gland0.84423261
111MP0001984_abnormal_olfaction0.83045988
112MP0000569_abnormal_digit_pigmentation0.81913324
113MP0001853_heart_inflammation0.81331569
114MP0002229_neurodegeneration0.79458561
115MP0002152_abnormal_brain_morphology0.78267121
116MP0003936_abnormal_reproductive_system0.77955175
117MP0004742_abnormal_vestibular_system0.75939636
118MP0006072_abnormal_retinal_apoptosis0.74885895
119MP0003631_nervous_system_phenotype0.74447070
120MP0002233_abnormal_nose_morphology0.73769739
121MP0003191_abnormal_cellular_cholesterol0.71989231
122MP0003123_paternal_imprinting0.71735007
123MP0008877_abnormal_DNA_methylation0.71489610
124MP0003890_abnormal_embryonic-extraembry0.70990276
125MP0005195_abnormal_posterior_eye0.70452660
126MP0000026_abnormal_inner_ear0.69954969
127MP0003633_abnormal_nervous_system0.69283087
128MP0004883_abnormal_blood_vessel0.69012761
129MP0001664_abnormal_digestion0.68733492
130MP0003634_abnormal_glial_cell0.68648782
131MP0005645_abnormal_hypothalamus_physiol0.68000664
132MP0002069_abnormal_eating/drinking_beha0.67931943
133MP0002972_abnormal_cardiac_muscle0.67916067
134MP0002752_abnormal_somatic_nervous0.67439754
135MP0004043_abnormal_pH_regulation0.66912756
136MP0006035_abnormal_mitochondrial_morpho0.66210087
137MP0001851_eye_inflammation0.65749012
138MP0005083_abnormal_biliary_tract0.65743954
139MP0002108_abnormal_muscle_morphology0.65333903
140MP0003938_abnormal_ear_development0.63295850
141MP0001986_abnormal_taste_sensitivity0.62902075
142MP0001542_abnormal_bone_strength0.61719629
143MP0001905_abnormal_dopamine_level0.61669154
144MP0005620_abnormal_muscle_contractility0.61055949
145MP0001270_distended_abdomen0.60566038
146MP0001943_abnormal_respiration0.58377209
147MP0000230_abnormal_systemic_arterial0.57651620

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.63969546
2Hyperventilation (HP:0002883)7.72471477
3Atonic seizures (HP:0010819)6.68176875
4Febrile seizures (HP:0002373)6.08791371
5Progressive inability to walk (HP:0002505)5.60463948
6Osteomalacia (HP:0002749)5.49724618
7Epileptic encephalopathy (HP:0200134)5.18683244
8Focal seizures (HP:0007359)4.86833940
9Acute necrotizing encephalopathy (HP:0006965)4.50674771
10Abnormality of the costochondral junction (HP:0000919)4.37765233
11Absence seizures (HP:0002121)4.32515792
12Progressive macrocephaly (HP:0004481)4.23834645
13Congenital stationary night blindness (HP:0007642)4.18750263
14Thoracolumbar scoliosis (HP:0002944)4.17600081
15Metaphyseal dysplasia (HP:0100255)4.17577384
16Myokymia (HP:0002411)4.10783634
17Rib fusion (HP:0000902)4.08584364
18Abnormal mitochondria in muscle tissue (HP:0008316)4.05262116
19Inability to walk (HP:0002540)4.01434398
20Widely patent fontanelles and sutures (HP:0004492)3.97540589
21Acute encephalopathy (HP:0006846)3.66674526
22Generalized tonic-clonic seizures (HP:0002069)3.65694041
23Dialeptic seizures (HP:0011146)3.55986491
24Abnormal social behavior (HP:0012433)3.55750225
25Impaired social interactions (HP:0000735)3.55750225
26Arterial tortuosity (HP:0005116)3.48284467
27Broad-based gait (HP:0002136)3.45712275
28Mitochondrial inheritance (HP:0001427)3.21404656
29Drooling (HP:0002307)3.05977168
30Excessive salivation (HP:0003781)3.05977168
31Adrenal hypoplasia (HP:0000835)3.05401344
32Abnormal gallbladder physiology (HP:0012438)3.00244510
33Cholecystitis (HP:0001082)3.00244510
34Absent speech (HP:0001344)2.98140412
35Optic disc pallor (HP:0000543)2.97158263
36Abnormal pancreas size (HP:0012094)2.91871418
37Papilledema (HP:0001085)2.90540640
38Delayed gross motor development (HP:0002194)2.89112875
39Vascular tortuosity (HP:0004948)2.88421922
40Progressive cerebellar ataxia (HP:0002073)2.84604842
41Cerebral edema (HP:0002181)2.83380514
42Progressive neurologic deterioration (HP:0002344)2.82448310
43Visual hallucinations (HP:0002367)2.82240568
44Dysdiadochokinesis (HP:0002075)2.78120074
45Neuroendocrine neoplasm (HP:0100634)2.77584236
46Increased CSF lactate (HP:0002490)2.76617088
47Anosmia (HP:0000458)2.74248990
48Amblyopia (HP:0000646)2.73230517
49Complement deficiency (HP:0004431)2.71749458
50Poor eye contact (HP:0000817)2.62218544
51Myotonia (HP:0002486)2.61297340
52Neoplasm of the peripheral nervous system (HP:0100007)2.61127231
53Protruding tongue (HP:0010808)2.61110882
54Abnormality of binocular vision (HP:0011514)2.60976850
55Diplopia (HP:0000651)2.60976850
56Pheochromocytoma (HP:0002666)2.60407753
57Hepatoblastoma (HP:0002884)2.57819560
58Gait imbalance (HP:0002141)2.55621156
59Labial hypoplasia (HP:0000066)2.54376382
60Thickened helices (HP:0000391)2.54284573
61Hyperlipoproteinemia (HP:0010980)2.52409380
62Rickets (HP:0002748)2.52072678
63Neoplasm of the adrenal cortex (HP:0100641)2.49658879
64Hepatocellular necrosis (HP:0001404)2.49582630
65Keratoconus (HP:0000563)2.48253577
66Increased corneal curvature (HP:0100692)2.48253577
67Abnormality of the diencephalon (HP:0010662)2.48169344
68Polyphagia (HP:0002591)2.47172847
69Spastic diplegia (HP:0001264)2.46313254
70Focal dystonia (HP:0004373)2.45426550
71Anomalous pulmonary venous return (HP:0010772)2.42081568
72Status epilepticus (HP:0002133)2.40982512
73Torticollis (HP:0000473)2.40375161
74Metaphyseal cupping (HP:0003021)2.39372936
75Blue irides (HP:0000635)2.37547526
76Premature loss of primary teeth (HP:0006323)2.34992668
77Epileptiform EEG discharges (HP:0011182)2.34775893
78Congenital primary aphakia (HP:0007707)2.34630322
79EEG with generalized epileptiform discharges (HP:0011198)2.34468893
80X-linked dominant inheritance (HP:0001423)2.33813565
81Enlarged kidneys (HP:0000105)2.33101541
82Hypsarrhythmia (HP:0002521)2.31830190
83Hypercalciuria (HP:0002150)2.31580648
84Potter facies (HP:0002009)2.30483528
85Facial shape deformation (HP:0011334)2.30483528
86Lipid accumulation in hepatocytes (HP:0006561)2.28173826
87Oligomenorrhea (HP:0000876)2.28132766
88Fair hair (HP:0002286)2.27999909
89Clumsiness (HP:0002312)2.27717759
90Hypoplastic labia majora (HP:0000059)2.27401024
91Truncal ataxia (HP:0002078)2.27064702
92Hypokinesia (HP:0002375)2.26636601
93Abnormality of macular pigmentation (HP:0008002)2.25312914
94Anxiety (HP:0000739)2.24182894
95Abnormality of the labia (HP:0000058)2.24151353
96Growth hormone excess (HP:0000845)2.23658690
97Congenital malformation of the right heart (HP:0011723)2.22489920
98Double outlet right ventricle (HP:0001719)2.22489920
99Esotropia (HP:0000565)2.21535519
100Hypoplastic female external genitalia (HP:0012815)2.20117023
101Xanthomatosis (HP:0000991)2.18278291
102Failure to thrive in infancy (HP:0001531)2.17472798
103Pachygyria (HP:0001302)2.17380654
104Medial flaring of the eyebrow (HP:0010747)2.17185928
105Generalized myoclonic seizures (HP:0002123)2.15982215
106Leukodystrophy (HP:0002415)2.12083576
107* Growth hormone deficiency (HP:0000824)2.11575724
108Neurofibrillary tangles (HP:0002185)2.10183724
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10103203
110Exercise intolerance (HP:0003546)2.09768856
111Disproportionate short-trunk short stature (HP:0003521)2.08452017
112Abnormal hair whorl (HP:0010721)2.07737230
113Psychosis (HP:0000709)2.06912233
114Chorioretinal atrophy (HP:0000533)2.05655252
115Abnormality of salivation (HP:0100755)2.05651706
116Pulmonary artery stenosis (HP:0004415)2.05538463
117Nephrogenic diabetes insipidus (HP:0009806)2.05402617
118Long foot (HP:0001833)2.05125556
119Cerebral inclusion bodies (HP:0100314)2.04110423
120Wide cranial sutures (HP:0010537)2.04062837
121Agitation (HP:0000713)2.03156259
122Abnormal eating behavior (HP:0100738)2.02383930
123Hyperthyroidism (HP:0000836)2.02368210
124Abnormality of the labia majora (HP:0012881)2.01704115
125Abnormality of the pulmonary veins (HP:0011718)2.01648556
126Poor coordination (HP:0002370)2.00789552
127Vertebral clefting (HP:0008428)1.99750879
128Epidermoid cyst (HP:0200040)1.98159632
129Intellectual disability, progressive (HP:0006887)1.97749366
130Mutism (HP:0002300)1.97003476
131Increased number of teeth (HP:0011069)1.96872159
132Fetal akinesia sequence (HP:0001989)1.96024730
133Increased hepatocellular lipid droplets (HP:0006565)1.95827134
134Spastic tetraplegia (HP:0002510)1.95110430
135Generalized hypopigmentation of hair (HP:0011358)1.94769784
136Acanthocytosis (HP:0001927)1.94366009
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93839199
138Craniofacial dystonia (HP:0012179)1.93060910
139Athetosis (HP:0002305)1.92696497
140Mesomelia (HP:0003027)1.92414835
141Supranuclear gaze palsy (HP:0000605)1.92339102
142Gaze-evoked nystagmus (HP:0000640)1.91971591
143Resting tremor (HP:0002322)1.89531949
144Narrow nasal bridge (HP:0000446)1.88341996
145Short middle phalanx of the 5th finger (HP:0004220)1.85972880
146Atrioventricular canal defect (HP:0006695)1.84455238
147Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84428185
148Abnormality of complement system (HP:0005339)1.83332114
149Exotropia (HP:0000577)1.80818353
150Methylmalonic acidemia (HP:0002912)1.80784015
151Abnormal vertebral ossification (HP:0100569)1.80751298
152Generalized hypotonia (HP:0001290)1.80412981
153Abnormality of the distal phalanges of the toes (HP:0010182)1.79817321
154Intellectual disability, severe (HP:0010864)1.79784321
155Axonal loss (HP:0003447)1.78975167
156Type II lissencephaly (HP:0007260)1.78937110
157Hemiparesis (HP:0001269)1.78789136
158Hepatic necrosis (HP:0002605)1.78634745
159Split foot (HP:0001839)1.77964808
160Genital tract atresia (HP:0001827)1.77948005
161Rhinitis (HP:0012384)1.77848235
162Neonatal hypoglycemia (HP:0001998)1.77096365
163Bradykinesia (HP:0002067)1.75913793
164Limb dystonia (HP:0002451)1.75533451
165Vaginal atresia (HP:0000148)1.75478854
166Pancreatic fibrosis (HP:0100732)1.75314337
167Hypercalcemia (HP:0003072)1.74671500
168Gait ataxia (HP:0002066)1.74127357
169Renal Fanconi syndrome (HP:0001994)1.73905050
170Poor suck (HP:0002033)1.73765666
171Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73009239
172Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70798588
173Lower limb asymmetry (HP:0100559)1.69687122
174Amyotrophic lateral sclerosis (HP:0007354)1.69309892
175Aplasia/Hypoplasia of the lens (HP:0008063)1.69255452
176Bifid tongue (HP:0010297)1.68688369
177Hand muscle atrophy (HP:0009130)1.67895124
178Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.67859021
179Mesangial abnormality (HP:0001966)1.67457385
180Neoplasm of head and neck (HP:0012288)1.66638915
181Postural instability (HP:0002172)1.66413632
182Spastic tetraparesis (HP:0001285)1.64820907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.29287535
2ERBB43.56088386
3NTRK33.49934441
4EPHA43.28068699
5MAP2K72.95028804
6MUSK2.81793060
7MAP3K122.77885428
8MAPK152.76820869
9MAP3K42.71425397
10AKT32.69275441
11TGFBR22.66804963
12PNCK2.62768390
13MAP2K42.57758425
14FES2.16819506
15NTRK22.11949517
16PLK21.72690375
17MINK11.69440260
18ARAF1.67832908
19DYRK21.64114130
20STK391.59408081
21MATK1.56023431
22PINK11.54324565
23UHMK11.51981505
24PDK41.47680979
25PDK31.47680979
26MAP3K111.47546552
27NTRK11.46588005
28CCNB11.42383739
29MAP3K61.40124768
30MOS1.37194750
31GRK71.32274798
32GRK51.28326502
33WNK41.26517572
34MARK11.25300623
35PAK61.25110715
36BRAF1.24021303
37PRKCE1.22575021
38MAP3K91.18107054
39TNK21.12641941
40TSSK61.12523898
41DAPK11.11761537
42SIK21.11318946
43PKN11.09346577
44GRK11.09233068
45PTK2B1.07773226
46CAMK2A1.07050574
47CDK51.06709366
48NUAK11.05288079
49MAPK41.05150873
50BCKDK1.04383254
51MAP4K21.02827805
52RIPK41.00853060
53CSNK1G21.00329277
54DYRK30.99005374
55CDK80.98842472
56OXSR10.98443501
57CAMK2B0.98226834
58KIT0.97478315
59WNK30.97352184
60SCYL20.96977612
61RPS6KA20.96877733
62DAPK20.96638865
63PRKCG0.96442437
64MAPK130.95819429
65FER0.95792372
66CDK190.94286121
67WNK10.93361818
68DAPK30.93157517
69FRK0.92942626
70MAPK120.91146051
71PIK3CA0.91087996
72NME10.89718117
73TNIK0.89605100
74CAMK1G0.88356278
75MAP2K20.86574957
76CAMK2D0.85674691
77MYLK0.83073558
78DMPK0.82541312
79ERN10.82414601
80FGR0.80813941
81ADRBK20.80733913
82MET0.79675426
83PRKCH0.79511863
84CAMKK20.79391129
85LIMK10.78569002
86PRKCZ0.75283953
87TGFBR10.72184964
88PDK20.71382817
89DYRK1B0.70928340
90CAMK10.70360529
91CAMK2G0.69865834
92ZAK0.69164617
93PAK30.65767979
94PRPF4B0.65729808
95EIF2AK10.65598631
96SGK4940.64840287
97SGK2230.64840287
98STK30.64525729
99GRK60.63968340
100CDK30.61861558
101PRKD30.59612221
102ICK0.57524509
103DYRK1A0.56831256
104EPHA30.56550421
105ALK0.56228969
106INSRR0.55858995
107PRKACA0.55779706
108BMPR20.54965567
109MAP3K50.54947498
110PTK20.52123660
111PRKD10.51627112
112TYRO30.51127806
113CSNK1G10.50794870
114CDK140.50758790
115CSNK1G30.50277668
116PRKG10.49214757
117PHKG10.49066340
118PHKG20.49066340
119PRKCI0.49057805
120SGK20.47498186
121FYN0.46768256
122CDK180.45596561
123PIM20.45305365
124PRKCB0.44083057
125CDK150.43911984
126CAMKK10.43377957
127ROCK20.42575642
128BMPR1B0.42152759
129LATS20.41352917
130CSNK1A1L0.39615238
131CAMK1D0.39579926
132PRKACB0.38915151
133PDGFRA0.38877998
134STK110.38201210
135SRC0.37606742
136RPS6KA30.36382862
137SIK30.35907389
138MAPKAPK20.35479466
139PAK10.35469610
140FGFR20.34970450
141PRKCD0.34948809
142CSNK1E0.33897356
143PRKACG0.33357844
144YES10.33249695
145PRKCA0.33052026
146MAPK70.32909349
147ADRBK10.32076276
148CDK11A0.31834470
149INSR0.31799547
150LATS10.31453900
151MAPK30.31260011

Predicted pathways (KEGG)

RankGene SetZ-score
1Folate biosynthesis_Homo sapiens_hsa007903.98636832
2Nicotine addiction_Homo sapiens_hsa050333.90393462
3Oxidative phosphorylation_Homo sapiens_hsa001903.64514327
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.61379875
5Synaptic vesicle cycle_Homo sapiens_hsa047213.32865752
6Collecting duct acid secretion_Homo sapiens_hsa049663.11362189
7GABAergic synapse_Homo sapiens_hsa047272.70404831
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61766412
9Parkinsons disease_Homo sapiens_hsa050122.36240949
10Morphine addiction_Homo sapiens_hsa050322.23201447
11Alzheimers disease_Homo sapiens_hsa050102.22524583
12Cardiac muscle contraction_Homo sapiens_hsa042602.22147662
13Butanoate metabolism_Homo sapiens_hsa006501.94239021
14Vibrio cholerae infection_Homo sapiens_hsa051101.89708161
15Glutamatergic synapse_Homo sapiens_hsa047241.83803577
16Sulfur relay system_Homo sapiens_hsa041221.78208670
17Circadian entrainment_Homo sapiens_hsa047131.76547673
18Taste transduction_Homo sapiens_hsa047421.76298535
19Serotonergic synapse_Homo sapiens_hsa047261.76055422
20Olfactory transduction_Homo sapiens_hsa047401.72734167
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63126958
22Huntingtons disease_Homo sapiens_hsa050161.59290297
23Salivary secretion_Homo sapiens_hsa049701.58106720
24Long-term potentiation_Homo sapiens_hsa047201.56123486
25Type I diabetes mellitus_Homo sapiens_hsa049401.54910568
26* Long-term depression_Homo sapiens_hsa047301.54457178
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48899144
28Dopaminergic synapse_Homo sapiens_hsa047281.45256729
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45107834
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43907912
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37857528
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36413652
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.35091893
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34181111
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32110129
36Amphetamine addiction_Homo sapiens_hsa050311.26526231
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25954565
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.24573132
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22049418
40Insulin secretion_Homo sapiens_hsa049111.18136867
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.17435566
42Gastric acid secretion_Homo sapiens_hsa049711.17312629
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15227913
44Oxytocin signaling pathway_Homo sapiens_hsa049211.12444306
45Pyruvate metabolism_Homo sapiens_hsa006201.11159320
46Cholinergic synapse_Homo sapiens_hsa047251.10301583
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10122632
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09952809
49Calcium signaling pathway_Homo sapiens_hsa040201.09521925
50Propanoate metabolism_Homo sapiens_hsa006401.04037477
51Renin secretion_Homo sapiens_hsa049241.03388368
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99925242
53Selenocompound metabolism_Homo sapiens_hsa004500.97471210
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97378307
55Rheumatoid arthritis_Homo sapiens_hsa053230.96924288
56Arachidonic acid metabolism_Homo sapiens_hsa005900.94648599
57Histidine metabolism_Homo sapiens_hsa003400.93669386
58Protein export_Homo sapiens_hsa030600.92713118
59Dilated cardiomyopathy_Homo sapiens_hsa054140.91445532
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90972364
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90392641
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88874121
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81888451
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80101472
65Sulfur metabolism_Homo sapiens_hsa009200.79062807
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.77996734
67Glutathione metabolism_Homo sapiens_hsa004800.77167590
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75793504
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75097806
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73585707
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73441435
72Phagosome_Homo sapiens_hsa041450.71090261
73Ovarian steroidogenesis_Homo sapiens_hsa049130.71077782
74beta-Alanine metabolism_Homo sapiens_hsa004100.69363480
75GnRH signaling pathway_Homo sapiens_hsa049120.68346271
76Gap junction_Homo sapiens_hsa045400.67276297
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66305830
78cAMP signaling pathway_Homo sapiens_hsa040240.64416244
79Estrogen signaling pathway_Homo sapiens_hsa049150.63997936
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.59279766
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58200367
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57950553
83Bile secretion_Homo sapiens_hsa049760.56966014
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.56335062
85Cocaine addiction_Homo sapiens_hsa050300.54273161
86Glycerolipid metabolism_Homo sapiens_hsa005610.53810934
87Type II diabetes mellitus_Homo sapiens_hsa049300.53109239
88Melanogenesis_Homo sapiens_hsa049160.52653577
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.51505753
90Steroid biosynthesis_Homo sapiens_hsa001000.51352135
91Peroxisome_Homo sapiens_hsa041460.51001020
92Glioma_Homo sapiens_hsa052140.50234459
93Thyroid hormone synthesis_Homo sapiens_hsa049180.50187307
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49467150
95Axon guidance_Homo sapiens_hsa043600.49370590
96Phototransduction_Homo sapiens_hsa047440.47926946
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.47926201
98Tryptophan metabolism_Homo sapiens_hsa003800.47592237
99Glucagon signaling pathway_Homo sapiens_hsa049220.46819076
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44802584
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44565731
102Ether lipid metabolism_Homo sapiens_hsa005650.44157141
103Fatty acid elongation_Homo sapiens_hsa000620.42449265
104Fatty acid biosynthesis_Homo sapiens_hsa000610.42123619
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41872487
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41310685
107Protein digestion and absorption_Homo sapiens_hsa049740.40940593
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40083254
109PPAR signaling pathway_Homo sapiens_hsa033200.38091924
110ErbB signaling pathway_Homo sapiens_hsa040120.37287396
111Carbon metabolism_Homo sapiens_hsa012000.37015856
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.36384638
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35908372
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35474404
115Melanoma_Homo sapiens_hsa052180.35351156
116Linoleic acid metabolism_Homo sapiens_hsa005910.34193133
117Rap1 signaling pathway_Homo sapiens_hsa040150.33581433
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33578316
119Tyrosine metabolism_Homo sapiens_hsa003500.33374468
120Prolactin signaling pathway_Homo sapiens_hsa049170.32743416
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32645871
122Pancreatic secretion_Homo sapiens_hsa049720.32549432
123Inositol phosphate metabolism_Homo sapiens_hsa005620.32173073
124Sphingolipid metabolism_Homo sapiens_hsa006000.31756282
125Oocyte meiosis_Homo sapiens_hsa041140.30951874
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29545163
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.28906212
128Circadian rhythm_Homo sapiens_hsa047100.28401605
129Chemokine signaling pathway_Homo sapiens_hsa040620.28379741
130African trypanosomiasis_Homo sapiens_hsa051430.28053637
131Metabolic pathways_Homo sapiens_hsa011000.27791439
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.27160547
133Ras signaling pathway_Homo sapiens_hsa040140.26733605
134Mineral absorption_Homo sapiens_hsa049780.25936667
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25525646
136MAPK signaling pathway_Homo sapiens_hsa040100.23383478
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.21988114
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20775983
139Renin-angiotensin system_Homo sapiens_hsa046140.20626328
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.20033417
141Other glycan degradation_Homo sapiens_hsa005110.19947764
142N-Glycan biosynthesis_Homo sapiens_hsa005100.18819217
143Phenylalanine metabolism_Homo sapiens_hsa003600.17893030

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