CREBRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.65845849
2positive regulation by symbiont of host defense response (GO:0052509)4.12169914
3modulation by symbiont of host defense response (GO:0052031)4.12169914
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12169914
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12169914
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.12169914
7modulation by symbiont of host immune response (GO:0052553)4.12169914
8detection of molecule of bacterial origin (GO:0032490)3.91650610
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87040505
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77434256
11microglial cell activation (GO:0001774)3.75069681
12macrophage activation involved in immune response (GO:0002281)3.65180595
13cellular extravasation (GO:0045123)3.61112344
14negative regulation of lymphocyte mediated immunity (GO:0002707)3.59568373
15positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.48117648
16activated T cell proliferation (GO:0050798)3.40926096
17negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.39814204
18negative regulation of T-helper cell differentiation (GO:0045623)3.39814204
19detection of other organism (GO:0098543)3.36089189
20regulation of interferon-beta biosynthetic process (GO:0045357)3.35092424
21negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34283818
22negative regulation of T cell mediated immunity (GO:0002710)3.31742265
23detection of external biotic stimulus (GO:0098581)3.29112516
24neutrophil activation involved in immune response (GO:0002283)3.28769762
25neutrophil mediated immunity (GO:0002446)3.23109891
26positive regulation of granulocyte differentiation (GO:0030854)3.20916714
27B cell receptor signaling pathway (GO:0050853)3.18381519
28positive T cell selection (GO:0043368)3.17328951
29neutrophil activation (GO:0042119)3.15994942
30myeloid leukocyte mediated immunity (GO:0002444)3.11433168
31macrophage activation (GO:0042116)3.10321428
32negative regulation of interleukin-12 production (GO:0032695)3.09137613
33regulation of ARF protein signal transduction (GO:0032012)3.07261341
34protein targeting to Golgi (GO:0000042)3.06617618
35response to host immune response (GO:0052572)3.04539559
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04539559
37negative regulation of leukocyte mediated immunity (GO:0002704)3.04433551
38regulation of protein polyubiquitination (GO:1902914)3.01758864
39interferon-gamma production (GO:0032609)3.01461180
40regulation of memory T cell differentiation (GO:0043380)3.00259032
41negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.00227869
42tolerance induction (GO:0002507)2.96292467
43detection of bacterium (GO:0016045)2.95431459
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92988836
45regulation of alpha-beta T cell proliferation (GO:0046640)2.91728716
46regulation of regulatory T cell differentiation (GO:0045589)2.88778166
47establishment of protein localization to Golgi (GO:0072600)2.87993872
48negative regulation of immunoglobulin mediated immune response (GO:0002890)2.86693880
49negative regulation of B cell mediated immunity (GO:0002713)2.86693880
50detection of biotic stimulus (GO:0009595)2.84324303
51histone H3-K4 trimethylation (GO:0080182)2.83712461
52myeloid cell activation involved in immune response (GO:0002275)2.83563903
53retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83119205
54positive thymic T cell selection (GO:0045059)2.81500139
55germinal center formation (GO:0002467)2.80284954
56interleukin-6-mediated signaling pathway (GO:0070102)2.80199652
57granulocyte activation (GO:0036230)2.79018602
58production of molecular mediator involved in inflammatory response (GO:0002532)2.78232546
59regulation of T cell mediated cytotoxicity (GO:0001914)2.77947547
60leukocyte aggregation (GO:0070486)2.77611113
61negative regulation of adaptive immune response (GO:0002820)2.76294749
62response to type I interferon (GO:0034340)2.75243164
63regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74092555
64cellular response to type I interferon (GO:0071357)2.73976855
65type I interferon signaling pathway (GO:0060337)2.73976855
66negative regulation of cAMP-mediated signaling (GO:0043951)2.72382296
67dendritic cell migration (GO:0036336)2.70389901
68cellular response to ethanol (GO:0071361)2.69896268
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69283399
70response to host (GO:0075136)2.69283399
71response to host defenses (GO:0052200)2.69283399
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69168030
73negative regulation of cell killing (GO:0031342)2.69168030
74interferon-gamma-mediated signaling pathway (GO:0060333)2.68720058
75response to peptidoglycan (GO:0032494)2.68621536
76regulation of tolerance induction (GO:0002643)2.68014803
77regulation of mast cell activation (GO:0033003)2.67899291
78T cell selection (GO:0045058)2.66768935
79T cell migration (GO:0072678)2.66576947
80regulation of B cell differentiation (GO:0045577)2.65864486
81cilium or flagellum-dependent cell motility (GO:0001539)2.64950900
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.64654016
83regulation of T cell tolerance induction (GO:0002664)2.62295226
84positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62097667
85regulation of germinal center formation (GO:0002634)2.61243686
86macroautophagy (GO:0016236)2.59475395
87antigen processing and presentation via MHC class Ib (GO:0002475)2.59212978
88negative regulation of neurotransmitter secretion (GO:0046929)2.59036960
89negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.57580250
90negative regulation of alpha-beta T cell activation (GO:0046636)2.55086672
91positive regulation of tolerance induction (GO:0002645)2.54116976
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.53512240
93immunoglobulin mediated immune response (GO:0016064)2.52705096
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51240872
95defense response to protozoan (GO:0042832)2.51081470
96growth hormone receptor signaling pathway (GO:0060396)2.45042119
97histone H3-K9 demethylation (GO:0033169)2.37222352
98cerebellar Purkinje cell differentiation (GO:0021702)2.36400575
99lipid translocation (GO:0034204)2.35172393
100phospholipid translocation (GO:0045332)2.35172393
101positive regulation of gamma-delta T cell activation (GO:0046645)2.35148821
102Golgi to endosome transport (GO:0006895)2.32453534
103cytoplasmic mRNA processing body assembly (GO:0033962)2.32009141
104phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.31829281
105prepulse inhibition (GO:0060134)2.30486250
106phosphatidylinositol dephosphorylation (GO:0046856)2.29708516
107phospholipid dephosphorylation (GO:0046839)2.27110782
108locomotory exploration behavior (GO:0035641)2.26762899
109antigen processing and presentation of endogenous antigen (GO:0019883)2.22859899
110ER overload response (GO:0006983)2.19028844
111negative regulation of inclusion body assembly (GO:0090084)2.18324860
112hypotonic response (GO:0006971)2.18287824
113antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.15381629
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.15381629
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.11526194
116regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.11110180
117regulation of synaptic vesicle exocytosis (GO:2000300)2.10470957
118calcium ion-dependent exocytosis (GO:0017156)2.10138203
119positive regulation of histone deacetylation (GO:0031065)2.09821249
120regulation of beta-amyloid formation (GO:1902003)2.09770929
121cellular response to growth hormone stimulus (GO:0071378)2.07734237
122negative regulation of neurotransmitter transport (GO:0051589)2.07438394
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.07183345
124potassium ion import (GO:0010107)2.05896741
125striatum development (GO:0021756)2.05658882
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.05054708
127positive regulation of cholesterol efflux (GO:0010875)2.03889743
128response to interleukin-15 (GO:0070672)2.03807590
129sodium ion export (GO:0071436)2.03716972
130negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.03342110
131negative regulation of translation, ncRNA-mediated (GO:0040033)2.03342110
132regulation of translation, ncRNA-mediated (GO:0045974)2.03342110
133positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.02496790
134cAMP catabolic process (GO:0006198)2.02369135
135cellular potassium ion homeostasis (GO:0030007)2.01508052
136cyclic nucleotide catabolic process (GO:0009214)2.01294485
137regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.00096420
138regulation of gamma-delta T cell differentiation (GO:0045586)1.99559685
139vesicle transport along microtubule (GO:0047496)1.99339742
140prostate gland growth (GO:0060736)1.98807629
141phosphatidylinositol phosphorylation (GO:0046854)1.97428259
142cellular response to interleukin-15 (GO:0071350)1.96503992
143piRNA metabolic process (GO:0034587)1.95489934
144regulation of establishment of cell polarity (GO:2000114)1.95201649
145CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)1.95017347
146T-helper cell differentiation (GO:0042093)1.95017347
147presynaptic membrane assembly (GO:0097105)1.94713318
148nerve growth factor signaling pathway (GO:0038180)1.93945482
149acrosome assembly (GO:0001675)1.93741222
150JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)1.92427369
151negative regulation of dendrite morphogenesis (GO:0050774)1.92318200
152histone H3-K36 demethylation (GO:0070544)1.91289703
153negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.89647279
154regulation of cAMP-dependent protein kinase activity (GO:2000479)1.87779776
155regulation of histone deacetylation (GO:0031063)1.87382966
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.86882075
157intracellular lipid transport (GO:0032365)1.86839084
158mating behavior (GO:0007617)1.86233865
159negative regulation of dendrite development (GO:2000171)1.86025055
160detection of calcium ion (GO:0005513)1.84825337
161protein K11-linked deubiquitination (GO:0035871)1.84694220
162calcium ion import (GO:0070509)1.84246193
163sperm motility (GO:0030317)1.83853361
164eye photoreceptor cell differentiation (GO:0001754)1.83685397
165photoreceptor cell differentiation (GO:0046530)1.83685397
166negative T cell selection (GO:0043383)1.83653097
167regulation of gamma-delta T cell activation (GO:0046643)1.83186146
168male meiosis (GO:0007140)1.81559249
169activation of protein kinase A activity (GO:0034199)1.81516315
170positive regulation of cholesterol transport (GO:0032376)1.80842231
171positive regulation of sterol transport (GO:0032373)1.80842231
172ovulation from ovarian follicle (GO:0001542)1.80709843
173negative thymic T cell selection (GO:0045060)1.80330871
174lipid phosphorylation (GO:0046834)1.79794618
175regulation of platelet aggregation (GO:0090330)1.79783121
176adaptation of signaling pathway (GO:0023058)1.79326492
177acrosome reaction (GO:0007340)1.78851249
178early endosome to late endosome transport (GO:0045022)1.78430107
179CD4-positive, alpha-beta T cell differentiation (GO:0043367)1.78252458
180dendritic cell chemotaxis (GO:0002407)1.78078036
181insulin secretion (GO:0030073)1.77410044
182suckling behavior (GO:0001967)1.77120545
183phospholipid homeostasis (GO:0055091)1.76710947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse2.61357741
2GBX2_23144817_ChIP-Seq_PC3_Human2.43878623
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35846526
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.20038073
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15692831
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13143853
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04555466
8TAF15_26573619_Chip-Seq_HEK293_Human2.03421062
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99325562
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94035981
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92533190
12GATA1_22025678_ChIP-Seq_K562_Human1.88908278
13MYB_26560356_Chip-Seq_TH2_Human1.74715683
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74650922
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74262292
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72011026
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70988887
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69660786
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.67418218
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66994236
21SCL_19346495_ChIP-Seq_HPC-7_Human1.66438436
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65457251
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64430280
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.63002655
25EZH2_22144423_ChIP-Seq_EOC_Human1.60833686
26SMAD4_21799915_ChIP-Seq_A2780_Human1.59385494
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57754315
28GATA3_27048872_Chip-Seq_THYMUS_Human1.54584894
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52731635
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.52368075
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50316209
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46762775
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46413183
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44787410
35AHR_22903824_ChIP-Seq_MCF-7_Human1.44658113
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.43686031
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.43430162
38RUNX_20019798_ChIP-Seq_JUKART_Human1.43263435
39GATA3_26560356_Chip-Seq_TH2_Human1.40212811
40STAT3_23295773_ChIP-Seq_U87_Human1.39906217
41P300_19829295_ChIP-Seq_ESCs_Human1.38818433
42SPI1_23127762_ChIP-Seq_K562_Human1.37855050
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33110757
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32377450
45BCAT_22108803_ChIP-Seq_LS180_Human1.29810081
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27787037
47MYB_26560356_Chip-Seq_TH1_Human1.25433128
48TCF4_23295773_ChIP-Seq_U87_Human1.24910805
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24543950
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23173167
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.22974905
52AR_25329375_ChIP-Seq_VCAP_Human1.22743209
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21200853
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20839539
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20777198
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20384913
57DROSHA_22980978_ChIP-Seq_HELA_Human1.19907614
58TP53_16413492_ChIP-PET_HCT116_Human1.19597668
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.18626493
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17323071
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17227050
62AR_21572438_ChIP-Seq_LNCaP_Human1.16195728
63ER_23166858_ChIP-Seq_MCF-7_Human1.15128241
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14856126
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14451678
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13737348
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13576826
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12541751
69SMRT_27268052_Chip-Seq_Bcells_Human1.11958797
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11807277
71SPI1_23547873_ChIP-Seq_NB4_Human1.11600772
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.10771890
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09876077
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08983228
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08569844
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08330314
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08271909
78IGF1R_20145208_ChIP-Seq_DFB_Human1.07845742
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07658465
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07658465
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05918958
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.05594729
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05162439
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04698730
85RUNX2_22187159_ChIP-Seq_PCA_Human1.02289230
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.01778641
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01749075
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.01745034
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.01712896
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01690168
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01673327
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.01542700
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01498132
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00252311
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99001767
96P53_22387025_ChIP-Seq_ESCs_Mouse0.98923437
97VDR_24787735_ChIP-Seq_THP-1_Human0.98785413
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.98715976
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.98046480
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97922090
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97617221
102STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97147764
103PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96755248
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.96745885
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.95915476
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95908894
107RXR_22108803_ChIP-Seq_LS180_Human0.95867258
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.95547579
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95536607
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94847269
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94847269
112GATA1_19941826_ChIP-Seq_K562_Human0.94587258
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94426673
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.93718983
115KDM2B_26808549_Chip-Seq_REH_Human0.93535059
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93491634
117OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93471342
118PU_27001747_Chip-Seq_BMDM_Mouse0.92880169
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92816833
120REST_21632747_ChIP-Seq_MESCs_Mouse0.92247158
121TP53_18474530_ChIP-ChIP_U2OS_Human0.92160292
122TCF4_22108803_ChIP-Seq_LS180_Human0.90989993
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90888882
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.90659802
125JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90607520
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90543220
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90452715
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90428289
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89787774
130PRDM14_20953172_ChIP-Seq_ESCs_Human0.89680397
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88660446
132VDR_24763502_ChIP-Seq_THP-1_Human0.88211145
133GATA2_19941826_ChIP-Seq_K562_Human0.87782702
134MAF_26560356_Chip-Seq_TH1_Human0.86872686
135* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85459731
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85179364
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.84341353
138CDX2_22108803_ChIP-Seq_LS180_Human0.83986193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.81920915
2MP0000569_abnormal_digit_pigmentation3.41670178
3MP0003436_decreased_susceptibility_to2.86953202
4MP0002009_preneoplasia2.77045377
5MP0004270_analgesia2.72397894
6MP0003303_peritoneal_inflammation2.63214345
7MP0002138_abnormal_hepatobiliary_system2.47492688
8MP0000685_abnormal_immune_system2.38978435
9MP0003300_gastrointestinal_ulcer2.37661474
10MP0003763_abnormal_thymus_physiology2.33562340
11MP0009785_altered_susceptibility_to2.32618482
12MP0002254_reproductive_system_inflammat2.31958902
13MP0002419_abnormal_innate_immunity2.29826812
14MP0003787_abnormal_imprinting2.24754119
15MP0005025_abnormal_response_to2.16303805
16MP0002420_abnormal_adaptive_immunity2.13063833
17MP0003045_fibrosis2.11211350
18MP0001819_abnormal_immune_cell2.10498069
19MP0009780_abnormal_chondrocyte_physiolo2.04238282
20MP0002166_altered_tumor_susceptibility2.02954357
21MP0003183_abnormal_peptide_metabolism2.02366134
22MP0002822_catalepsy2.02170028
23MP0004381_abnormal_hair_follicle2.01256233
24MP0006082_CNS_inflammation1.94044034
25MP0004130_abnormal_muscle_cell1.88957352
26MP0005646_abnormal_pituitary_gland1.86088801
27MP0009046_muscle_twitch1.85489158
28MP0000013_abnormal_adipose_tissue1.84406559
29MP0002405_respiratory_system_inflammati1.82517562
30MP0002148_abnormal_hypersensitivity_rea1.79767076
31MP0005310_abnormal_salivary_gland1.75855452
32MP0010234_abnormal_vibrissa_follicle1.74998529
33MP0005670_abnormal_white_adipose1.71753361
34MP0003828_pulmonary_edema1.69333831
35MP0002909_abnormal_adrenal_gland1.66661348
36MP0009764_decreased_sensitivity_to1.64830659
37MP0004883_abnormal_blood_vessel1.64798165
38MP0000716_abnormal_immune_system1.63359036
39MP0005645_abnormal_hypothalamus_physiol1.63183904
40MP0002877_abnormal_melanocyte_morpholog1.62778623
41MP0003690_abnormal_glial_cell1.62291505
42MP0004885_abnormal_endolymph1.62088367
43MP0003172_abnormal_lysosome_physiology1.61454233
44MP0001790_abnormal_immune_system1.61043615
45MP0005387_immune_system_phenotype1.61043615
46MP0002398_abnormal_bone_marrow1.59774770
47MP0004484_altered_response_of1.55698771
48MP0001661_extended_life_span1.54957107
49MP0001533_abnormal_skeleton_physiology1.54485113
50MP0001845_abnormal_inflammatory_respons1.52927192
51MP0003195_calcinosis1.51905419
52MP0002876_abnormal_thyroid_physiology1.50924367
53MP0003635_abnormal_synaptic_transmissio1.50242671
54MP0003880_abnormal_central_pattern1.50151246
55MP0000465_gastrointestinal_hemorrhage1.49626854
56MP0005075_abnormal_melanosome_morpholog1.48889021
57MP0004510_myositis1.48661675
58MP0005410_abnormal_fertilization1.48541633
59MP0001501_abnormal_sleep_pattern1.47354882
60MP0010155_abnormal_intestine_physiology1.45082638
61MP0005535_abnormal_body_temperature1.43246915
62MP0005666_abnormal_adipose_tissue1.42967668
63MP0004859_abnormal_synaptic_plasticity1.42352614
64MP0003656_abnormal_erythrocyte_physiolo1.41500729
65MP0000689_abnormal_spleen_morphology1.40710127
66MP0001835_abnormal_antigen_presentation1.39926504
67MP0002064_seizures1.36186355
68MP0009745_abnormal_behavioral_response1.36018603
69MP0005365_abnormal_bile_salt1.34019273
70MP0002277_abnormal_respiratory_mucosa1.33248641
71MP0002928_abnormal_bile_duct1.31429031
72MP0001984_abnormal_olfaction1.31293132
73MP0005551_abnormal_eye_electrophysiolog1.30476021
74MP0003633_abnormal_nervous_system1.30219871
75MP0002837_dystrophic_cardiac_calcinosis1.30168993
76MP0001486_abnormal_startle_reflex1.29950065
77MP0004185_abnormal_adipocyte_glucose1.29368868
78MP0002722_abnormal_immune_system1.28094811
79MP0005164_abnormal_response_to1.27318533
80MP0001851_eye_inflammation1.27179013
81MP0002139_abnormal_hepatobiliary_system1.26398822
82MP0004947_skin_inflammation1.26290292
83MP0003191_abnormal_cellular_cholesterol1.25681713
84MP0002006_tumorigenesis1.23981860
85MP0005174_abnormal_tail_pigmentation1.23576335
86MP0000703_abnormal_thymus_morphology1.20895230
87MP0001765_abnormal_ion_homeostasis1.19863484
88MP0005167_abnormal_blood-brain_barrier1.19233047
89MP0005375_adipose_tissue_phenotype1.17981045
90MP0003252_abnormal_bile_duct1.17973163
91MP0002272_abnormal_nervous_system1.17756056
92MP0002971_abnormal_brown_adipose1.16260323
93MP0008877_abnormal_DNA_methylation1.14571889
94MP0004742_abnormal_vestibular_system1.13584803
95MP0002429_abnormal_blood_cell1.13446852
96MP0010386_abnormal_urinary_bladder1.12671498
97MP0002998_abnormal_bone_remodeling1.11784312
98MP0004043_abnormal_pH_regulation1.11676114
99MP0010329_abnormal_lipoprotein_level1.11567319
100MP0008469_abnormal_protein_level1.11424842
101MP0008260_abnormal_autophagy1.11328431
102MP0001879_abnormal_lymphatic_vessel1.10528683
103MP0002572_abnormal_emotion/affect_behav1.09248033
104MP0000920_abnormal_myelination1.08690503
105MP0000003_abnormal_adipose_tissue1.07309394
106MP0003868_abnormal_feces_composition1.03456625
107MP0008961_abnormal_basal_metabolism1.00985934
108MP0003646_muscle_fatigue0.99668237
109MP0002078_abnormal_glucose_homeostasis0.98775040
110MP0008569_lethality_at_weaning0.98648320
111MP0002063_abnormal_learning/memory/cond0.98559032
112MP0002067_abnormal_sensory_capabilities0.98207129
113MP0000015_abnormal_ear_pigmentation0.98079671
114MP0005671_abnormal_response_to0.97925669
115MP0002693_abnormal_pancreas_physiology0.97763479
116MP0001177_atelectasis0.95880509
117MP0005334_abnormal_fat_pad0.94744653
118MP0002168_other_aberrant_phenotype0.94230330
119MP0001800_abnormal_humoral_immune0.93801142
120MP0002118_abnormal_lipid_homeostasis0.93282249
121MP0001986_abnormal_taste_sensitivity0.93057092
122MP0008874_decreased_physiological_sensi0.88764791
123MP0002132_abnormal_respiratory_system0.87768768
124MP0001502_abnormal_circadian_rhythm0.87428559
125MP0002332_abnormal_exercise_endurance0.85908881
126MP0005397_hematopoietic_system_phenotyp0.85494187
127MP0001545_abnormal_hematopoietic_system0.85494187
128MP0006072_abnormal_retinal_apoptosis0.85037913
129MP0004924_abnormal_behavior0.84752947
130MP0005386_behavior/neurological_phenoty0.84752947
131MP0002723_abnormal_immune_serum0.84630463
132MP0002396_abnormal_hematopoietic_system0.84581693
133MP0002734_abnormal_mechanical_nocicepti0.82902337
134MP0001958_emphysema0.82017849
135MP0003631_nervous_system_phenotype0.80650055
136MP0005253_abnormal_eye_physiology0.80103677
137MP0008057_abnormal_DNA_replication0.80028751
138MP0009333_abnormal_splenocyte_physiolog0.79787975
139MP0002229_neurodegeneration0.79397430
140MP0001944_abnormal_pancreas_morphology0.78884278
141MP0003866_abnormal_defecation0.78505193
142MP0005000_abnormal_immune_tolerance0.78477459
143MP0008004_abnormal_stomach_pH0.76276471
144MP0001440_abnormal_grooming_behavior0.76189959
145MP0000249_abnormal_blood_vessel0.75495540
146MP0003634_abnormal_glial_cell0.74969320
147MP0002452_abnormal_antigen_presenting0.74702944
148MP0002090_abnormal_vision0.74649758
149MP0005379_endocrine/exocrine_gland_phen0.74470026
150MP0000230_abnormal_systemic_arterial0.74174869
151MP0005464_abnormal_platelet_physiology0.73503140
152MP0005448_abnormal_energy_balance0.73180065
153MP0002933_joint_inflammation0.71982198
154MP0006054_spinal_hemorrhage0.70305324
155MP0001853_heart_inflammation0.67573418
156MP0005166_decreased_susceptibility_to0.66303616
157MP0005376_homeostasis/metabolism_phenot0.65957918
158MP0003221_abnormal_cardiomyocyte_apopto0.62400461
159MP0000604_amyloidosis0.60866670
160MP0001663_abnormal_digestive_system0.60145193
161MP0004808_abnormal_hematopoietic_stem0.59606111
162MP0003011_delayed_dark_adaptation0.58690055
163MP0009115_abnormal_fat_cell0.58233638
164MP0004142_abnormal_muscle_tone0.57751848
165MP0001873_stomach_inflammation0.57308525
166MP0002136_abnormal_kidney_physiology0.56536838

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)4.98949989
2Retrobulbar optic neuritis (HP:0100654)4.98949989
3Eczematoid dermatitis (HP:0000976)4.84631434
4Orchitis (HP:0100796)4.69941309
5Myositis (HP:0100614)4.67336997
6Stomatitis (HP:0010280)4.52698841
7Recurrent bacterial skin infections (HP:0005406)4.40348763
8Elevated erythrocyte sedimentation rate (HP:0003565)4.35944266
9Recurrent abscess formation (HP:0002722)4.04692338
10Neonatal hypoglycemia (HP:0001998)3.88400964
11Gastrointestinal infarctions (HP:0005244)3.83469268
12Keratoconjunctivitis sicca (HP:0001097)3.66648689
13Recurrent fungal infections (HP:0002841)3.59684087
14Keratoconjunctivitis (HP:0001096)3.57928475
15Neoplasm of the adrenal cortex (HP:0100641)3.56158073
16Abnormal pancreas size (HP:0012094)3.42151087
17Recurrent cutaneous fungal infections (HP:0011370)3.35938518
18Chronic mucocutaneous candidiasis (HP:0002728)3.35938518
19Recurrent gram-negative bacterial infections (HP:0005420)3.26998056
20Abnormality of macrophages (HP:0004311)3.22181533
21Hepatoblastoma (HP:0002884)3.19618864
22Recurrent skin infections (HP:0001581)3.19560018
23Absent/shortened dynein arms (HP:0200106)3.15455952
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.15455952
25Abnormal glucose tolerance (HP:0001952)3.12903904
26Vasculitis (HP:0002633)3.12644445
27Encephalitis (HP:0002383)3.11182488
28Hemoptysis (HP:0002105)3.06832690
29Meningitis (HP:0001287)3.02291018
30Stomach cancer (HP:0012126)2.98034865
31Febrile seizures (HP:0002373)2.97046898
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.96896707
33Mediastinal lymphadenopathy (HP:0100721)2.96403837
34Abnormality of the fingertips (HP:0001211)2.95398994
35Pulmonary infiltrates (HP:0002113)2.95140002
36Abnormality of T cells (HP:0002843)2.82650658
37Long foot (HP:0001833)2.80133251
38Chest pain (HP:0100749)2.76603190
39Hypochromic microcytic anemia (HP:0004840)2.74423142
40Leukocytosis (HP:0001974)2.70438614
41Gingivitis (HP:0000230)2.69156188
42Gingival bleeding (HP:0000225)2.68672142
43Prolonged bleeding time (HP:0003010)2.66427088
44Arterial thrombosis (HP:0004420)2.62999193
45Abnormal respiratory motile cilium physiology (HP:0012261)2.62532863
46Pulmonary embolism (HP:0002204)2.57081591
47Neoplasm of the tracheobronchial system (HP:0100552)2.52243030
48Pustule (HP:0200039)2.41726359
49Focal motor seizures (HP:0011153)2.40624026
50Papilledema (HP:0001085)2.40469419
51Recurrent bronchitis (HP:0002837)2.38735235
52Abnormal ciliary motility (HP:0012262)2.37792847
53Hematochezia (HP:0002573)2.35518790
54Chronic sinusitis (HP:0011109)2.35514780
55Atonic seizures (HP:0010819)2.33395675
56Gaze-evoked nystagmus (HP:0000640)2.32770875
57Alveolar cell carcinoma (HP:0006519)2.29843969
58Narrow palate (HP:0000189)2.28054647
59Progressive cerebellar ataxia (HP:0002073)2.27041142
60Hypochromic anemia (HP:0001931)2.26018647
61Microcytic anemia (HP:0001935)2.25202002
62Epistaxis (HP:0000421)2.24707849
63Autoimmune hemolytic anemia (HP:0001890)2.23736606
64Increased IgE level (HP:0003212)2.23691873
65Episodic fever (HP:0001954)2.23589939
66Anorexia (HP:0002039)2.23518080
67Eosinophilia (HP:0001880)2.22798460
68Chronic hepatic failure (HP:0100626)2.22792206
69Hypothermia (HP:0002045)2.22463584
70Abnormality of eosinophils (HP:0001879)2.22135427
71Abnormality of the pleura (HP:0002103)2.20941677
72Recurrent sinusitis (HP:0011108)2.20516331
73Gangrene (HP:0100758)2.20474206
74Chronic obstructive pulmonary disease (HP:0006510)2.19867734
75Obstructive lung disease (HP:0006536)2.19867734
76Enlarged kidneys (HP:0000105)2.19251107
77Macroorchidism (HP:0000053)2.18634939
78Focal seizures (HP:0007359)2.17964363
79Bronchitis (HP:0012387)2.17916506
80Peritonitis (HP:0002586)2.16781286
81Hyperkalemia (HP:0002153)2.16056828
82Agammaglobulinemia (HP:0004432)2.14674877
83Rhinitis (HP:0012384)2.13081749
84Gastrointestinal stroma tumor (HP:0100723)2.12755712
85Bronchiectasis (HP:0002110)2.11379669
86Urticaria (HP:0001025)2.10571159
87Abnormality of T cell physiology (HP:0011840)2.09056599
88Action tremor (HP:0002345)2.08786819
89Keratitis (HP:0000491)2.07666829
90Truncal ataxia (HP:0002078)2.07462567
91Myocardial infarction (HP:0001658)2.06317356
92Papillary thyroid carcinoma (HP:0002895)2.05966143
93Acute myeloid leukemia (HP:0004808)2.04927755
94Blue irides (HP:0000635)2.03616583
95Genetic anticipation (HP:0003743)2.03466826
96Acanthocytosis (HP:0001927)2.02926407
97Increased CSF protein (HP:0002922)2.02354064
98Hyperventilation (HP:0002883)2.01627504
99Inflammation of the large intestine (HP:0002037)2.01502429
100Vertigo (HP:0002321)2.01257953
101Panhypogammaglobulinemia (HP:0003139)2.00629084
102Subacute progressive viral hepatitis (HP:0006572)1.97670911
103Chronic otitis media (HP:0000389)1.97387875
104Overgrowth (HP:0001548)1.96834320
105Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96683603
106Oligomenorrhea (HP:0000876)1.96584690
107Drooling (HP:0002307)1.96402654
108Excessive salivation (HP:0003781)1.96402654
109Colitis (HP:0002583)1.96101591
110Pigmentary retinal degeneration (HP:0001146)1.95183345
111Hemiplegia (HP:0002301)1.94753065
112Granulocytopenia (HP:0001913)1.93693851
113Intention tremor (HP:0002080)1.93519294
114Insulin-resistant diabetes mellitus (HP:0000831)1.91250479
115Truncal obesity (HP:0001956)1.91198755
116Deep philtrum (HP:0002002)1.91177731
117Widely spaced teeth (HP:0000687)1.90924632
118Abnormality of the endocardium (HP:0004306)1.88985993
119IgG deficiency (HP:0004315)1.88938186
120Abnormal hair whorl (HP:0010721)1.88794965
121Poor coordination (HP:0002370)1.87607419
122Infertility (HP:0000789)1.87071189
123Chronic bronchitis (HP:0004469)1.86688413
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85844613
125Broad-based gait (HP:0002136)1.85689115
126Nasal polyposis (HP:0100582)1.85429948
127Osteomyelitis (HP:0002754)1.85080928
128Glucose intolerance (HP:0000833)1.82890849
129Postural instability (HP:0002172)1.79906407
130Abnormality of the nasal mucosa (HP:0000433)1.79461721
131Generalized hypopigmentation of hair (HP:0011358)1.78976210
132Abnormal rod and cone electroretinograms (HP:0008323)1.76644936
133Abnormal respiratory epithelium morphology (HP:0012253)1.75683946
134Abnormal respiratory motile cilium morphology (HP:0005938)1.75683946
135Polyneuropathy (HP:0001271)1.75614080
136Acute hepatic failure (HP:0006554)1.75368613
137Abnormality of T cell number (HP:0011839)1.73700335
138Progressive inability to walk (HP:0002505)1.73468546
139Autoimmune thrombocytopenia (HP:0001973)1.73061243
140Lymphopenia (HP:0001888)1.72549260
141Facial diplegia (HP:0001349)1.72510659
142T lymphocytopenia (HP:0005403)1.72335484
143Hyperglycemia (HP:0003074)1.72309536
144Gastrointestinal inflammation (HP:0004386)1.71588162
145Slow saccadic eye movements (HP:0000514)1.70467748
146Hypokalemic alkalosis (HP:0001949)1.70340071
147Decreased circulating renin level (HP:0003351)1.69388120
148Fair hair (HP:0002286)1.69203968
149Bony spicule pigmentary retinopathy (HP:0007737)1.68872652
150Symptomatic seizures (HP:0011145)1.68237732
151Viral hepatitis (HP:0006562)1.67635282
152Abnormality of the pericardium (HP:0001697)1.66463207
153Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66025683
154Acne (HP:0001061)1.65954271
155Abnormality of ocular smooth pursuit (HP:0000617)1.65498402
156Abnormal delayed hypersensitivity skin test (HP:0002963)1.65364696
157Joint swelling (HP:0001386)1.64692245
158Hypoglycemic seizures (HP:0002173)1.62351497
159Epileptic encephalopathy (HP:0200134)1.60441468
160Abnormality of the periventricular white matter (HP:0002518)1.59126252
161Hypomagnesemia (HP:0002917)1.58609843
162Global brain atrophy (HP:0002283)1.58535640
163Thyroiditis (HP:0100646)1.56833521
164Abnormality of the renal medulla (HP:0100957)1.55083289
165Progressive visual loss (HP:0000529)1.53755876
166Abnormality of chloride homeostasis (HP:0011422)1.52988169
167Abnormality of incisor morphology (HP:0011063)1.51217242
168Resting tremor (HP:0002322)1.50885739
169Dysmetric saccades (HP:0000641)1.50879983
170Volvulus (HP:0002580)1.50399099
171Thickened helices (HP:0000391)1.50166142
172Metabolic alkalosis (HP:0200114)1.49199696
173Chronic diarrhea (HP:0002028)1.48979068
174Nephronophthisis (HP:0000090)1.48817589
175Abnormality of potassium homeostasis (HP:0011042)1.48648872
176Recurrent viral infections (HP:0004429)1.47915573
177Dysmetria (HP:0001310)1.47546544
178Spontaneous hematomas (HP:0007420)1.47239999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.33058226
2FRK2.64786813
3TXK2.39490181
4SGK22.26268955
5INSRR2.14682227
6IRAK42.07953378
7MAP3K42.03929656
8SGK31.96240888
9FGFR31.95971331
10JAK11.93535726
11MAP3K131.86674759
12MAP3K21.86239493
13RIPK11.80106964
14FGFR21.75984356
15RIPK41.74436919
16CSK1.70384762
17WNK11.65386611
18CAMK1G1.64171132
19SGK4941.63648627
20SGK2231.63648627
21GRK61.60798862
22PRKCH1.60415847
23CAMK1D1.60014975
24TAOK31.53425730
25BTK1.45476652
26NTRK31.45471543
27MAP2K31.40980146
28ZAP701.40815463
29MAP3K141.39693722
30FGFR41.39254152
31MAP2K41.38378555
32HIPK21.35827704
33AKT31.32398485
34PIK3CG1.29748171
35TGFBR21.29542002
36TYK21.28092290
37PRKD31.26166250
38ACVR1B1.26154403
39MAP3K121.23939222
40PRKG21.23008931
41KIT1.21884053
42STK391.16799598
43SIK21.16375122
44IRAK21.15916429
45MAP2K71.14831541
46JAK31.10000595
47LYN1.09484761
48PDK11.07055830
49RET1.05394955
50IKBKE1.03649547
51PDK31.01621969
52PDK41.01621969
53WNK41.01608252
54CAMKK21.01568013
55ITK1.00943019
56YES10.99450276
57EPHA30.99425461
58LCK0.98950668
59SGK10.97831787
60NLK0.96737732
61GRK70.93535940
62GRK10.93490422
63TBK10.93328414
64JAK20.92718011
65CASK0.90147940
66NEK60.89790697
67PDGFRB0.88382429
68SIK10.86837409
69CDK90.86517929
70PRKD20.85897094
71BMPR20.85878017
72PAK30.85684660
73PDK20.85034437
74MAP4K10.84748537
75EPHB10.83867250
76TEC0.81733864
77PINK10.81259200
78PRKAA20.80749211
79MAP3K30.79467222
80IRAK10.79409217
81FGR0.78299770
82TRPM70.77626529
83MAP3K70.77271821
84PDGFRA0.76406800
85PRKCQ0.75844288
86MARK20.75252430
87NTRK20.74528949
88EPHA40.73769909
89CAMK40.73607149
90PDPK10.72747856
91NEK90.71659094
92CHUK0.70933248
93CDK30.70631469
94STK110.69860132
95CSF1R0.69814821
96IRAK30.67913775
97NUAK10.66747871
98TIE10.66541566
99CAMK2B0.65000093
100PRKAA10.64992804
101SIK30.64862909
102STK380.63946177
103PRPF4B0.63278628
104WNK30.62131860
105ADRBK20.61756788
106MAP3K90.60885019
107TNK20.60330150
108MARK30.60150461
109LMTK20.59823542
110MAP3K10.59497058
111OXSR10.59144510
112MAP3K60.59024767
113IKBKB0.58595374
114TAOK10.57681323
115MAPK130.57661342
116PIM10.57036199
117MAPK120.54661685
118FES0.54461443
119PRKCE0.53662793
120CDK50.52837042
121SYK0.52632799
122MAPK150.51909335
123DYRK1B0.50945884
124HCK0.50658225
125PIK3CA0.49831014
126DAPK20.49315618
127CAMKK10.49298997
128NTRK10.48940033
129MAPK70.48801813
130MAP3K50.48657552
131PKN10.48372623
132KSR20.47978742
133CAMK10.46914973
134DYRK1A0.46818898
135PTK2B0.46699964
136MATK0.46660700
137BRD40.46476757
138FER0.45682579
139TNIK0.45675281
140DYRK30.43101261
141ADRBK10.42142041

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.23770472
2Staphylococcus aureus infection_Homo sapiens_hsa051502.18727690
3Allograft rejection_Homo sapiens_hsa053302.03856359
4Graft-versus-host disease_Homo sapiens_hsa053322.01347543
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96858454
6Autoimmune thyroid disease_Homo sapiens_hsa053201.91152586
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81233096
8Renin secretion_Homo sapiens_hsa049241.74667011
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.69193046
10Type I diabetes mellitus_Homo sapiens_hsa049401.65782217
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63726681
12Tuberculosis_Homo sapiens_hsa051521.59319282
13Type II diabetes mellitus_Homo sapiens_hsa049301.58730218
14Insulin secretion_Homo sapiens_hsa049111.57055448
15Measles_Homo sapiens_hsa051621.56575664
16Olfactory transduction_Homo sapiens_hsa047401.55326712
17Nitrogen metabolism_Homo sapiens_hsa009101.52609921
18Long-term potentiation_Homo sapiens_hsa047201.50181680
19Salivary secretion_Homo sapiens_hsa049701.49330473
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47191221
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44812809
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39717075
23Dorso-ventral axis formation_Homo sapiens_hsa043201.38810263
24Hematopoietic cell lineage_Homo sapiens_hsa046401.37882428
25Gastric acid secretion_Homo sapiens_hsa049711.37228403
26Inositol phosphate metabolism_Homo sapiens_hsa005621.35188496
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33262130
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30741087
29Circadian entrainment_Homo sapiens_hsa047131.29979647
30Morphine addiction_Homo sapiens_hsa050321.28363809
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26015827
32Malaria_Homo sapiens_hsa051441.25757410
33Asthma_Homo sapiens_hsa053101.25373522
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24321508
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23789639
36ABC transporters_Homo sapiens_hsa020101.21518898
37TNF signaling pathway_Homo sapiens_hsa046681.20659638
38Phototransduction_Homo sapiens_hsa047441.16274043
39Amphetamine addiction_Homo sapiens_hsa050311.15532869
40Glutamatergic synapse_Homo sapiens_hsa047241.15116848
41Influenza A_Homo sapiens_hsa051641.13957090
42B cell receptor signaling pathway_Homo sapiens_hsa046621.09128575
43GABAergic synapse_Homo sapiens_hsa047271.08259328
44Nicotine addiction_Homo sapiens_hsa050331.07798328
45Antigen processing and presentation_Homo sapiens_hsa046121.06917071
46Cholinergic synapse_Homo sapiens_hsa047251.06436747
47Dopaminergic synapse_Homo sapiens_hsa047281.06139944
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05875506
49Acute myeloid leukemia_Homo sapiens_hsa052211.05840322
50Long-term depression_Homo sapiens_hsa047301.04591410
51African trypanosomiasis_Homo sapiens_hsa051431.04471148
52Pancreatic secretion_Homo sapiens_hsa049721.04242470
53Osteoclast differentiation_Homo sapiens_hsa043801.02563907
54Glucagon signaling pathway_Homo sapiens_hsa049221.01155851
55cAMP signaling pathway_Homo sapiens_hsa040241.00453062
56Lysine degradation_Homo sapiens_hsa003100.98979952
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98146652
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97896590
59Herpes simplex infection_Homo sapiens_hsa051680.96852872
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.96178192
61Glycerolipid metabolism_Homo sapiens_hsa005610.95656763
62Legionellosis_Homo sapiens_hsa051340.95635638
63Non-small cell lung cancer_Homo sapiens_hsa052230.94559144
64Taste transduction_Homo sapiens_hsa047420.94071728
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.94000544
66Insulin resistance_Homo sapiens_hsa049310.93700340
67Thyroid hormone synthesis_Homo sapiens_hsa049180.92100154
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91502878
69Calcium signaling pathway_Homo sapiens_hsa040200.89678082
70Chemokine signaling pathway_Homo sapiens_hsa040620.88145238
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87970963
72Hepatitis B_Homo sapiens_hsa051610.87769662
73Cocaine addiction_Homo sapiens_hsa050300.87147503
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.86776774
75GnRH signaling pathway_Homo sapiens_hsa049120.86127626
76Estrogen signaling pathway_Homo sapiens_hsa049150.84773030
77Serotonergic synapse_Homo sapiens_hsa047260.83911004
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83118310
79Oxytocin signaling pathway_Homo sapiens_hsa049210.82756391
80Synaptic vesicle cycle_Homo sapiens_hsa047210.82642157
81PPAR signaling pathway_Homo sapiens_hsa033200.82106051
82Viral myocarditis_Homo sapiens_hsa054160.81420669
83Rheumatoid arthritis_Homo sapiens_hsa053230.80608806
84Circadian rhythm_Homo sapiens_hsa047100.79377227
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.78546337
86Platelet activation_Homo sapiens_hsa046110.77818056
87Phagosome_Homo sapiens_hsa041450.77266348
88T cell receptor signaling pathway_Homo sapiens_hsa046600.76938457
89Prolactin signaling pathway_Homo sapiens_hsa049170.76267224
90Primary immunodeficiency_Homo sapiens_hsa053400.75853830
91FoxO signaling pathway_Homo sapiens_hsa040680.75832115
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.75152147
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75029699
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74456159
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73323562
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73274898
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.72951062
98Renal cell carcinoma_Homo sapiens_hsa052110.72824162
99Linoleic acid metabolism_Homo sapiens_hsa005910.72484168
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71987171
101Choline metabolism in cancer_Homo sapiens_hsa052310.71610720
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.70755360
103Glioma_Homo sapiens_hsa052140.70745981
104Fatty acid biosynthesis_Homo sapiens_hsa000610.68507364
105VEGF signaling pathway_Homo sapiens_hsa043700.66175361
106Caffeine metabolism_Homo sapiens_hsa002320.64297312
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.64200482
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64041082
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.63906754
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62990451
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62855134
112Bile secretion_Homo sapiens_hsa049760.62818078
113Pertussis_Homo sapiens_hsa051330.62519863
114MAPK signaling pathway_Homo sapiens_hsa040100.62508351
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.61439540
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61065003
117Pancreatic cancer_Homo sapiens_hsa052120.60133720
118Propanoate metabolism_Homo sapiens_hsa006400.59449543
119Vitamin B6 metabolism_Homo sapiens_hsa007500.59140651
120ErbB signaling pathway_Homo sapiens_hsa040120.59053711
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58144759
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.57078895
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56937498
124Insulin signaling pathway_Homo sapiens_hsa049100.55834836
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55754764
126Endometrial cancer_Homo sapiens_hsa052130.54311709
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53489709
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53271105
129Collecting duct acid secretion_Homo sapiens_hsa049660.53024698
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53009065
131mTOR signaling pathway_Homo sapiens_hsa041500.52649427
132Ras signaling pathway_Homo sapiens_hsa040140.50826123
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50709637
134Hepatitis C_Homo sapiens_hsa051600.50056880
135Ether lipid metabolism_Homo sapiens_hsa005650.49093647
136Mineral absorption_Homo sapiens_hsa049780.48572221
137Apoptosis_Homo sapiens_hsa042100.46758366
138Gap junction_Homo sapiens_hsa045400.46525499
139AMPK signaling pathway_Homo sapiens_hsa041520.46277215
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46005208
141Toxoplasmosis_Homo sapiens_hsa051450.45888013
142Prostate cancer_Homo sapiens_hsa052150.44929560
143Regulation of autophagy_Homo sapiens_hsa041400.44900311
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44731956
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44565829

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