CREBL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.78356201
2L-phenylalanine catabolic process (GO:0006559)5.78356201
3L-phenylalanine metabolic process (GO:0006558)5.56670610
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56670610
5aromatic amino acid family catabolic process (GO:0009074)5.38631924
6indole-containing compound catabolic process (GO:0042436)5.09272097
7indolalkylamine catabolic process (GO:0046218)5.09272097
8tryptophan catabolic process (GO:0006569)5.09272097
9tryptophan metabolic process (GO:0006568)4.74792975
10sulfur amino acid catabolic process (GO:0000098)4.67468042
11kynurenine metabolic process (GO:0070189)4.65917266
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.46414093
13bile acid biosynthetic process (GO:0006699)4.45316624
14high-density lipoprotein particle remodeling (GO:0034375)4.35216495
15alpha-linolenic acid metabolic process (GO:0036109)4.15250597
16glyoxylate metabolic process (GO:0046487)4.14588846
17complement activation, alternative pathway (GO:0006957)4.12314749
18positive regulation of cellular amide metabolic process (GO:0034250)4.11697551
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.08350520
20bile acid metabolic process (GO:0008206)4.07503418
21urea metabolic process (GO:0019627)4.01585072
22urea cycle (GO:0000050)4.01585072
23cholesterol efflux (GO:0033344)3.95858481
24triglyceride homeostasis (GO:0070328)3.91486408
25acylglycerol homeostasis (GO:0055090)3.91486408
26protein carboxylation (GO:0018214)3.89740188
27peptidyl-glutamic acid carboxylation (GO:0017187)3.89740188
28regulation of cholesterol esterification (GO:0010872)3.88959005
29regulation of protein activation cascade (GO:2000257)3.85269008
30aromatic amino acid family metabolic process (GO:0009072)3.84123988
31phospholipid efflux (GO:0033700)3.83127583
32reverse cholesterol transport (GO:0043691)3.78190989
33cysteine metabolic process (GO:0006534)3.77987269
34nitrogen cycle metabolic process (GO:0071941)3.77485739
35very-low-density lipoprotein particle assembly (GO:0034379)3.71450892
36drug catabolic process (GO:0042737)3.70202493
37serine family amino acid catabolic process (GO:0009071)3.70146208
38homocysteine metabolic process (GO:0050667)3.64284190
39indolalkylamine metabolic process (GO:0006586)3.63657281
40cellular biogenic amine catabolic process (GO:0042402)3.62376072
41amine catabolic process (GO:0009310)3.62376072
42plasma lipoprotein particle remodeling (GO:0034369)3.60742800
43protein-lipid complex remodeling (GO:0034368)3.60742800
44macromolecular complex remodeling (GO:0034367)3.60742800
45regulation of complement activation (GO:0030449)3.60722179
46amino-acid betaine metabolic process (GO:0006577)3.55308245
47alpha-amino acid catabolic process (GO:1901606)3.54736101
48NAD biosynthetic process (GO:0009435)3.53871471
49negative regulation of cell killing (GO:0031342)3.53806572
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53806572
51negative regulation of fibrinolysis (GO:0051918)3.53554752
52regulation of triglyceride catabolic process (GO:0010896)3.50420447
53tyrosine metabolic process (GO:0006570)3.50205335
54alkaloid metabolic process (GO:0009820)3.49630413
55glycosphingolipid catabolic process (GO:0046479)3.49312178
56regulation of fibrinolysis (GO:0051917)3.46403319
57cytolysis (GO:0019835)3.42532092
58low-density lipoprotein particle remodeling (GO:0034374)3.42422891
59cellular response to thyroid hormone stimulus (GO:0097067)3.38773834
60cellular amino acid catabolic process (GO:0009063)3.38533182
61coenzyme catabolic process (GO:0009109)3.35514296
62plasma lipoprotein particle assembly (GO:0034377)3.31993855
63proline metabolic process (GO:0006560)3.31194035
64glutamate metabolic process (GO:0006536)3.29854313
65negative regulation of fatty acid biosynthetic process (GO:0045717)3.25245236
66intestinal cholesterol absorption (GO:0030299)3.21657316
67bile acid and bile salt transport (GO:0015721)3.21020137
68benzene-containing compound metabolic process (GO:0042537)3.19993692
69glutamine family amino acid biosynthetic process (GO:0009084)3.19601632
70nicotinamide nucleotide biosynthetic process (GO:0019359)3.17800823
71pyridine nucleotide biosynthetic process (GO:0019363)3.17800823
72glycolipid catabolic process (GO:0019377)3.15779996
73imidazole-containing compound metabolic process (GO:0052803)3.14435014
74positive regulation of gamma-delta T cell activation (GO:0046645)3.11781259
75detection of molecule of bacterial origin (GO:0032490)3.09699123
76dicarboxylic acid biosynthetic process (GO:0043650)3.08306547
77proline biosynthetic process (GO:0006561)3.08256212
78plasma lipoprotein particle organization (GO:0071827)3.05521730
79exogenous drug catabolic process (GO:0042738)3.02927324
80phospholipid homeostasis (GO:0055091)3.02104928
81valine metabolic process (GO:0006573)3.01263794
82negative regulation of cholesterol transport (GO:0032375)3.01145759
83negative regulation of sterol transport (GO:0032372)3.01145759
84organic acid catabolic process (GO:0016054)3.01009289
85carboxylic acid catabolic process (GO:0046395)3.01009289
86short-chain fatty acid metabolic process (GO:0046459)2.99578337
87regulation of cholesterol homeostasis (GO:2000188)2.99041092
88regulation of beta-amyloid formation (GO:1902003)2.98254095
89cofactor catabolic process (GO:0051187)2.97540778
90cellular glucuronidation (GO:0052695)2.97241277
91cellular modified amino acid catabolic process (GO:0042219)2.94903928
92macrophage activation involved in immune response (GO:0002281)2.93646965
93regulation of bile acid biosynthetic process (GO:0070857)2.93587870
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92340607
95cellular ketone body metabolic process (GO:0046950)2.90105398
96complement activation, classical pathway (GO:0006958)2.89819300
97monocarboxylic acid catabolic process (GO:0072329)2.86771273
98lysine metabolic process (GO:0006553)2.86767046
99lysine catabolic process (GO:0006554)2.86767046
100drug transmembrane transport (GO:0006855)2.86720901
101plasma lipoprotein particle clearance (GO:0034381)2.85946290
102neutrophil activation involved in immune response (GO:0002283)2.85635107
103protein-lipid complex assembly (GO:0065005)2.84247503
104opsonization (GO:0008228)2.84222654
105regulation of protein homooligomerization (GO:0032462)2.84127075
106peptide catabolic process (GO:0043171)2.83842367
107protein localization to endosome (GO:0036010)2.83249493
108fatty acid oxidation (GO:0019395)2.83052030
109complement activation (GO:0006956)2.82511475
110fatty acid beta-oxidation (GO:0006635)2.82464381
111negative regulation of lipase activity (GO:0060192)2.81704494
112regulation of cholesterol biosynthetic process (GO:0045540)2.80519630
113lipid oxidation (GO:0034440)2.79966397
114regulation of mononuclear cell migration (GO:0071675)2.79860890
115protein-lipid complex subunit organization (GO:0071825)2.79505921
116barbed-end actin filament capping (GO:0051016)2.78405983
117response to thyroid hormone (GO:0097066)2.76291877
118virion attachment to host cell (GO:0019062)2.75052102
119adhesion of symbiont to host cell (GO:0044650)2.75052102
120N-acetylneuraminate metabolic process (GO:0006054)2.70739781
121ceramide catabolic process (GO:0046514)2.69575331
122oligosaccharide catabolic process (GO:0009313)2.68716504
123hypotonic response (GO:0006971)2.67098285
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.66550258
125apoptotic cell clearance (GO:0043277)2.65351263
126negative regulation of interleukin-12 production (GO:0032695)2.64756718
127negative regulation of erythrocyte differentiation (GO:0045647)2.63942101
128negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61311825
129response to peptidoglycan (GO:0032494)2.60703730
130detection of external biotic stimulus (GO:0098581)2.60165594
131regulation of macrophage chemotaxis (GO:0010758)2.59939927
132mannose metabolic process (GO:0006013)2.59000333
133positive regulation of Rap GTPase activity (GO:0032854)2.57210182
134detection of other organism (GO:0098543)2.53732480
135regulation of T-helper 2 cell differentiation (GO:0045628)2.53574184
136regulation of cellular amide metabolic process (GO:0034248)2.52170796
137cellular response to ethanol (GO:0071361)2.51885597
138macroautophagy (GO:0016236)2.51739200
139keratan sulfate catabolic process (GO:0042340)2.50807480
140amino sugar catabolic process (GO:0046348)2.50584146
141positive regulation of receptor recycling (GO:0001921)2.49932746
142regulation of early endosome to late endosome transport (GO:2000641)2.46215749
143regulation of amyloid precursor protein catabolic process (GO:1902991)2.44917227
144adhesion of symbiont to host (GO:0044406)2.44662710
145modulation by symbiont of host immune response (GO:0052553)2.40967971
146positive regulation by symbiont of host defense response (GO:0052509)2.40967971
147modulation by symbiont of host defense response (GO:0052031)2.40967971
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.40967971
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.40967971
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.40967971
151positive regulation of leukocyte degranulation (GO:0043302)2.40913842
152regulation of gamma-delta T cell activation (GO:0046643)2.39137670
153Rap protein signal transduction (GO:0032486)2.37584831
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.36469017
155regulation of cholesterol storage (GO:0010885)2.36382238
156negative regulation of complement activation (GO:0045916)2.36272877
157regulation of apoptotic cell clearance (GO:2000425)2.35148943
158cellular extravasation (GO:0045123)2.34190121
159interferon-gamma-mediated signaling pathway (GO:0060333)2.33492345
160T-helper 1 type immune response (GO:0042088)2.32723299
161antigen processing and presentation of endogenous antigen (GO:0019883)2.32642524
162regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31185113
163positive regulation of cholesterol efflux (GO:0010875)2.29416054
164negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.29117195
165antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.29113031
166iron ion import (GO:0097286)2.28122884
167nerve growth factor signaling pathway (GO:0038180)2.27195812
168immunoglobulin mediated immune response (GO:0016064)2.26669840
169positive regulation of sterol transport (GO:0032373)2.25937126
170positive regulation of cholesterol transport (GO:0032376)2.25937126
171negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.25536545
172membrane lipid catabolic process (GO:0046466)2.24986891
173cortical cytoskeleton organization (GO:0030865)2.24821123
174negative regulation of protein localization to plasma membrane (GO:1903077)2.24790632
175positive regulation of macrophage cytokine production (GO:0060907)2.24272693
176regulation of ARF protein signal transduction (GO:0032012)2.22898239
177macrophage activation (GO:0042116)2.21609402
178negative regulation of humoral immune response (GO:0002921)2.21563121
179sphingolipid catabolic process (GO:0030149)2.20744619
180lipopolysaccharide-mediated signaling pathway (GO:0031663)2.20304243
181detection of bacterium (GO:0016045)2.20218645
182angiotensin maturation (GO:0002003)2.19878149
183positive regulation of type 2 immune response (GO:0002830)2.19831274
184detection of biotic stimulus (GO:0009595)2.18584188
185production of molecular mediator involved in inflammatory response (GO:0002532)2.16551336
186response to laminar fluid shear stress (GO:0034616)2.13932429
187negative regulation of protein activation cascade (GO:2000258)2.13308079
188regulation of transforming growth factor beta1 production (GO:0032908)2.12555505
189regulation of type 2 immune response (GO:0002828)2.11890707
190regulation of Rap GTPase activity (GO:0032317)2.11632827
191positive regulation of mast cell activation (GO:0033005)2.10507752
192regulation of tolerance induction (GO:0002643)2.08329799
193positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.07690232
194regulation of T cell tolerance induction (GO:0002664)2.07511769
195regulation of dendritic cell antigen processing and presentation (GO:0002604)2.05573156
196negative regulation of interleukin-17 production (GO:0032700)2.05342661
197regulation of leukocyte degranulation (GO:0043300)2.05062542
198negative regulation of type 2 immune response (GO:0002829)2.02617039
199negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.02369731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.28805143
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.12930097
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.19451305
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.14352685
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.09363398
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.84094739
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.89611348
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.78505563
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40745224
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34302029
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.32259491
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.24481258
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21053581
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08862476
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05689534
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01777357
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98097791
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.90667976
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85408986
20VDR_24787735_ChIP-Seq_THP-1_Human1.60325941
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58097673
22GBX2_23144817_ChIP-Seq_PC3_Human1.57620388
23GATA1_22025678_ChIP-Seq_K562_Human1.56707302
24CLOCK_20551151_ChIP-Seq_293T_Human1.46999011
25SPI1_23127762_ChIP-Seq_K562_Human1.42466267
26RUNX_20019798_ChIP-Seq_JUKART_Human1.42179260
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41237169
28* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40039732
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38484399
30* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37654727
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34254319
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32608102
33* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28506619
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.27720601
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26082830
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24640568
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22874531
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20094082
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17499267
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15133042
41SOX2_20726797_ChIP-Seq_SW620_Human1.14562459
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.14557638
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14493023
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.11272727
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11160804
46GATA1_19941826_ChIP-Seq_K562_Human1.09876467
47* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09673580
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09425672
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08614219
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07897179
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06897675
52PU_27001747_Chip-Seq_BMDM_Mouse1.06111020
53* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05767767
54HTT_18923047_ChIP-ChIP_STHdh_Human1.04920098
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04661845
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04595681
57KDM2B_26808549_Chip-Seq_K562_Human1.04387472
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01269992
59GATA2_19941826_ChIP-Seq_K562_Human0.98990833
60ERG_21242973_ChIP-ChIP_JURKAT_Human0.98895823
61IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98773434
62* TBX20_22080862_ChIP-Seq_HEART_Mouse0.98015685
63* TBX20_22328084_ChIP-Seq_HEART_Mouse0.98015685
64EP300_21415370_ChIP-Seq_HL-1_Mouse0.96461899
65GATA2_21666600_ChIP-Seq_HMVEC_Human0.95975647
66SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95709918
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94316472
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93816010
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93574541
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93351965
71WT1_19549856_ChIP-ChIP_CCG9911_Human0.93330767
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91378223
73TP63_23658742_ChIP-Seq_EP156T_Human0.91030745
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90614423
75RUNX1_22412390_ChIP-Seq_EML_Mouse0.90538506
76VDR_24763502_ChIP-Seq_THP-1_Human0.90433641
77SCL_19346495_ChIP-Seq_HPC-7_Human0.90227094
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89204598
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88947431
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88947431
81TRIM28_21343339_ChIP-Seq_HEK293_Human0.88887063
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88671086
83NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88049354
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87586472
85TAF15_26573619_Chip-Seq_HEK293_Human0.87249916
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87194297
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86389840
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86002866
89PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85533224
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85242565
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84663533
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84634833
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84629319
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84275707
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84066285
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83951735
97* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83302783
98IRF1_19129219_ChIP-ChIP_H3396_Human0.83047862
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82801374
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.82267808
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81868021
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81729678
103STAT3_18555785_Chip-Seq_ESCs_Mouse0.81670899
104RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81143031
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80940648
106TCF7_22412390_ChIP-Seq_EML_Mouse0.80866223
107CJUN_26792858_Chip-Seq_BT549_Human0.80737224
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.80648275
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.80390276
110REST_21632747_ChIP-Seq_MESCs_Mouse0.79377985
111AHR_22903824_ChIP-Seq_MCF-7_Human0.79329982
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79115406
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79028670
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78936224
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78343433
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78205419
117P300_18555785_Chip-Seq_ESCs_Mouse0.77832866
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.77396615
119* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76990540
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76924909
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75679914
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.75649023
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.75579504
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75233524
125SMAD1_18555785_Chip-Seq_ESCs_Mouse0.74904180
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74667811
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74523637
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74140678
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.73275268
130P53_22387025_ChIP-Seq_ESCs_Mouse0.72706826
131OCT4_18555785_Chip-Seq_ESCs_Mouse0.72570685
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.72221173
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.71858623
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.71526173
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.71300343
136NMYC_18555785_Chip-Seq_ESCs_Mouse0.71196692
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.71173122
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70981187
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.70887984
140CTCF_18555785_Chip-Seq_ESCs_Mouse0.70636982
141SMAD4_21799915_ChIP-Seq_A2780_Human0.70542148
142SOX2_18555785_Chip-Seq_ESCs_Mouse0.70016994
143PU1_27457419_Chip-Seq_LIVER_Mouse0.69575098
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.69561790
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.68737856
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67556096
147KLF4_18555785_Chip-Seq_ESCs_Mouse0.67171624
148CDX2_19796622_ChIP-Seq_MESCs_Mouse0.66965770
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.66535709
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.66503715
151SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.66298025
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.66111369
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66111369
154KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66111369
155P300_19829295_ChIP-Seq_ESCs_Human0.65616263
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.65427521
157MYC_27129775_Chip-Seq_CORNEA_Mouse0.65266575
158PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65026718
159* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64689544
160DROSHA_22980978_ChIP-Seq_HELA_Human0.64646194
161ZNF217_24962896_ChIP-Seq_MCF-7_Human0.64495635
162PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64131556
163PIAS1_25552417_ChIP-Seq_VCAP_Human0.63757737
164EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.62268910
165EGR1_19032775_ChIP-ChIP_M12_Human0.61735636
166SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.61674506
167BCAT_22108803_ChIP-Seq_LS180_Human0.61497399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.72927539
2MP0005085_abnormal_gallbladder_physiolo5.57098009
3MP0005360_urolithiasis5.43177813
4MP0005365_abnormal_bile_salt5.29294059
5MP0008875_abnormal_xenobiotic_pharmacok4.00566322
6MP0003300_gastrointestinal_ulcer3.26766361
7MP0003252_abnormal_bile_duct3.12840448
8MP0003303_peritoneal_inflammation3.08016380
9MP0010329_abnormal_lipoprotein_level2.82958487
10MP0003195_calcinosis2.72427870
11MP0003806_abnormal_nucleotide_metabolis2.63660898
12MP0005332_abnormal_amino_acid2.38975582
13MP0010234_abnormal_vibrissa_follicle2.23885972
14MP0004019_abnormal_vitamin_homeostasis2.23877804
15MP0003191_abnormal_cellular_cholesterol2.11771331
16MP0001666_abnormal_nutrient_absorption2.07664978
17MP0005083_abnormal_biliary_tract2.07075318
18MP0002876_abnormal_thyroid_physiology2.03522002
19MP0008004_abnormal_stomach_pH2.02304075
20MP0002118_abnormal_lipid_homeostasis1.95816669
21MP0002138_abnormal_hepatobiliary_system1.94285028
22MP0000569_abnormal_digit_pigmentation1.94158439
23MP0009840_abnormal_foam_cell1.91864679
24MP0002419_abnormal_innate_immunity1.84706638
25MP0003329_amyloid_beta_deposits1.82339478
26MP0002009_preneoplasia1.74875957
27MP0000609_abnormal_liver_physiology1.72065536
28MP0002998_abnormal_bone_remodeling1.69994570
29MP0001533_abnormal_skeleton_physiology1.69610756
30MP0001764_abnormal_homeostasis1.68613107
31MP0000343_altered_response_to1.65939450
32MP0005647_abnormal_sex_gland1.56877064
33MP0003183_abnormal_peptide_metabolism1.53944212
34MP0005319_abnormal_enzyme/_coenzyme1.52363790
35MP0009764_decreased_sensitivity_to1.52185153
36MP0000015_abnormal_ear_pigmentation1.49750354
37MP0005000_abnormal_immune_tolerance1.49304042
38MP0005584_abnormal_enzyme/coenzyme_acti1.47322862
39MP0001958_emphysema1.44710116
40MP0003091_abnormal_cell_migration1.43782281
41MP0000920_abnormal_myelination1.42286519
42MP0005167_abnormal_blood-brain_barrier1.41274816
43MP0005166_decreased_susceptibility_to1.38799704
44MP0004947_skin_inflammation1.36128563
45MP0003279_aneurysm1.32440288
46MP0005535_abnormal_body_temperature1.30806845
47MP0003868_abnormal_feces_composition1.30565053
48MP0010352_gastrointestinal_tract_polyps1.29911167
49MP0003828_pulmonary_edema1.29582499
50MP0005646_abnormal_pituitary_gland1.29368593
51MP0003879_abnormal_hair_cell1.27502577
52MP0002909_abnormal_adrenal_gland1.26598503
53MP0008260_abnormal_autophagy1.25548007
54MP0001835_abnormal_antigen_presentation1.23827135
55MP0003705_abnormal_hypodermis_morpholog1.19995335
56MP0010155_abnormal_intestine_physiology1.19801230
57MP0004510_myositis1.19799898
58MP0002452_abnormal_antigen_presenting1.19414218
59MP0003656_abnormal_erythrocyte_physiolo1.18701841
60MP0005257_abnormal_intraocular_pressure1.18460146
61MP0003690_abnormal_glial_cell1.15994643
62MP0005379_endocrine/exocrine_gland_phen1.15891936
63MP0009780_abnormal_chondrocyte_physiolo1.13913907
64MP0005645_abnormal_hypothalamus_physiol1.13200889
65MP0000685_abnormal_immune_system1.13097068
66MP0006082_CNS_inflammation1.12149638
67MP0005058_abnormal_lysosome_morphology1.11816472
68MP0003448_altered_tumor_morphology1.10958513
69MP0002723_abnormal_immune_serum1.10910560
70MP0005164_abnormal_response_to1.10560395
71MP0005171_absent_coat_pigmentation1.09064661
72MP0003186_abnormal_redox_activity1.09014243
73MP0003075_altered_response_to1.08560942
74MP0009643_abnormal_urine_homeostasis1.07472951
75MP0004883_abnormal_blood_vessel1.07181711
76MP0004130_abnormal_muscle_cell1.06798849
77MP0005666_abnormal_adipose_tissue1.06332213
78MP0008874_decreased_physiological_sensi1.04678875
79MP0002254_reproductive_system_inflammat1.04493580
80MP0003724_increased_susceptibility_to1.04388336
81MP0001800_abnormal_humoral_immune1.03355089
82MP0005409_darkened_coat_color1.01172522
83MP0009697_abnormal_copulation0.97902445
84MP0002078_abnormal_glucose_homeostasis0.96928522
85MP0008469_abnormal_protein_level0.96209531
86MP0005464_abnormal_platelet_physiology0.96162057
87MP0002405_respiratory_system_inflammati0.95548166
88MP0002163_abnormal_gland_morphology0.94798023
89MP0008438_abnormal_cutaneous_collagen0.94398640
90MP0004043_abnormal_pH_regulation0.94238544
91MP0000639_abnormal_adrenal_gland0.93369258
92MP0000465_gastrointestinal_hemorrhage0.92975381
93MP0004782_abnormal_surfactant_physiolog0.92712940
94MP0001542_abnormal_bone_strength0.92078318
95MP0002420_abnormal_adaptive_immunity0.91720886
96MP0001819_abnormal_immune_cell0.91646356
97MP0002166_altered_tumor_susceptibility0.91452319
98MP0001502_abnormal_circadian_rhythm0.91447324
99MP0005451_abnormal_body_composition0.90501795
100MP0003634_abnormal_glial_cell0.89927072
101MP0002971_abnormal_brown_adipose0.89397535
102MP0000858_altered_metastatic_potential0.88202075
103MP0000249_abnormal_blood_vessel0.88023728
104MP0003011_delayed_dark_adaptation0.87970859
105MP0004142_abnormal_muscle_tone0.86818191
106MP0005375_adipose_tissue_phenotype0.84764504
107MP0001851_eye_inflammation0.84763517
108MP0002896_abnormal_bone_mineralization0.84438319
109MP0001853_heart_inflammation0.84319572
110MP0005275_abnormal_skin_tensile0.83685504
111MP0001790_abnormal_immune_system0.83061626
112MP0005387_immune_system_phenotype0.83061626
113MP0009642_abnormal_blood_homeostasis0.82520761
114MP0006054_spinal_hemorrhage0.82440836
115MP0005165_increased_susceptibility_to0.82271120
116MP0001986_abnormal_taste_sensitivity0.82246295
117MP0008995_early_reproductive_senescence0.79482829
118MP0000371_diluted_coat_color0.79385709
119MP0009046_muscle_twitch0.79254772
120MP0003633_abnormal_nervous_system0.79027339
121MP0008872_abnormal_physiological_respon0.77802656
122MP0002132_abnormal_respiratory_system0.77230562
123MP0003566_abnormal_cell_adhesion0.77083262
124MP0002090_abnormal_vision0.76415370
125MP0005636_abnormal_mineral_homeostasis0.76221463
126MP0002822_catalepsy0.75906906
127MP0005334_abnormal_fat_pad0.75504352
128MP0000598_abnormal_liver_morphology0.75038655
129MP0009765_abnormal_xenobiotic_induced0.74744075
130MP0002148_abnormal_hypersensitivity_rea0.74687682
131MP0005448_abnormal_energy_balance0.74343340
132MP0000604_amyloidosis0.73612186
133MP0009763_increased_sensitivity_to0.72496813
134MP0002928_abnormal_bile_duct0.72494882
135MP0005671_abnormal_response_to0.71964015
136MP0009785_altered_susceptibility_to0.71722440
137MP0005310_abnormal_salivary_gland0.71088992
138MP0006036_abnormal_mitochondrial_physio0.68520572
139MP0005376_homeostasis/metabolism_phenot0.67955665
140MP0003638_abnormal_response/metabolism_0.67865280
141MP0003953_abnormal_hormone_level0.66623147
142MP0003436_decreased_susceptibility_to0.64557427
143MP0005670_abnormal_white_adipose0.61666091
144MP0005025_abnormal_response_to0.61415671
145MP0003172_abnormal_lysosome_physiology0.61409519
146MP0001845_abnormal_inflammatory_respons0.61335091
147MP0002006_tumorigenesis0.61157171
148MP0001501_abnormal_sleep_pattern0.59724771
149MP0005084_abnormal_gallbladder_morpholo0.59602559
150MP0003631_nervous_system_phenotype0.59080467
151MP0005248_abnormal_Harderian_gland0.58779376
152MP0003959_abnormal_lean_body0.58333410
153MP0009115_abnormal_fat_cell0.58050826
154MP0003453_abnormal_keratinocyte_physiol0.57224176
155MP0003045_fibrosis0.57154221
156MP0002877_abnormal_melanocyte_morpholog0.56995927
157MP0005075_abnormal_melanosome_morpholog0.55960963

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.69665394
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.69202419
3Abnormality of glycolipid metabolism (HP:0010969)5.45899985
4Abnormality of liposaccharide metabolism (HP:0010968)5.45899985
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.45899985
6Prolonged partial thromboplastin time (HP:0003645)5.01173697
7Deep venous thrombosis (HP:0002625)4.81311182
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.78657281
9Hypobetalipoproteinemia (HP:0003563)4.50062392
10Complement deficiency (HP:0004431)4.19307193
11Xanthomatosis (HP:0000991)4.18525660
12Vacuolated lymphocytes (HP:0001922)4.01386472
13Joint hemorrhage (HP:0005261)3.98179289
14Hypochromic microcytic anemia (HP:0004840)3.94617415
15Hyperlipoproteinemia (HP:0010980)3.86980760
16Dysostosis multiplex (HP:0000943)3.71904681
17Eczematoid dermatitis (HP:0000976)3.63538545
18Conjugated hyperbilirubinemia (HP:0002908)3.60750759
19Abnormality of the common coagulation pathway (HP:0010990)3.52855010
20Fat malabsorption (HP:0002630)3.52229635
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.47901852
22Ketosis (HP:0001946)3.42964833
23Abnormality of macrophages (HP:0004311)3.38060667
24Hyperammonemia (HP:0001987)3.38058306
25Hyperglycinemia (HP:0002154)3.31237436
26Epidermoid cyst (HP:0200040)3.29986803
27Abnormality of methionine metabolism (HP:0010901)3.29025284
28Increased IgM level (HP:0003496)3.25894989
29Abnormality of the intrinsic pathway (HP:0010989)3.24172046
30Increased cerebral lipofuscin (HP:0011813)3.23855020
31Neurofibrillary tangles (HP:0002185)3.23040467
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.18450095
33Hypolipoproteinemia (HP:0010981)3.12803360
34Loss of speech (HP:0002371)3.12563825
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.08246981
36Recurrent bacterial skin infections (HP:0005406)3.07027799
37Axonal loss (HP:0003447)3.03632671
38Myocardial infarction (HP:0001658)2.99673279
39Hyperglycinuria (HP:0003108)2.96847095
40Recurrent abscess formation (HP:0002722)2.96487327
41Ketoacidosis (HP:0001993)2.95887202
42Hypoglycemic coma (HP:0001325)2.94741651
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.91605514
44Abnormality of complement system (HP:0005339)2.90326729
45Abnormality of serine family amino acid metabolism (HP:0010894)2.84347548
46Abnormality of glycine metabolism (HP:0010895)2.84347548
47Steatorrhea (HP:0002570)2.82607066
48Spontaneous hematomas (HP:0007420)2.79521974
49Hematochezia (HP:0002573)2.78087538
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69621073
51Mutism (HP:0002300)2.61672360
52Febrile seizures (HP:0002373)2.60429939
53Generalized aminoaciduria (HP:0002909)2.60331374
54Disinhibition (HP:0000734)2.58780233
55Hypercholesterolemia (HP:0003124)2.58579957
56Systemic lupus erythematosus (HP:0002725)2.57903511
57Hypoglycemic seizures (HP:0002173)2.57444050
58Hypoalphalipoproteinemia (HP:0003233)2.56348671
59Increased CSF protein (HP:0002922)2.55713966
60Cerebral inclusion bodies (HP:0100314)2.55682964
61Abnormality of fatty-acid metabolism (HP:0004359)2.51209759
62Hyperbilirubinemia (HP:0002904)2.51000133
63Recurrent gram-negative bacterial infections (HP:0005420)2.50377844
64Alopecia of scalp (HP:0002293)2.47449193
65Spontaneous abortion (HP:0005268)2.46628715
66Symptomatic seizures (HP:0011145)2.43607880
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39492701
68Gingival bleeding (HP:0000225)2.39457139
69Menorrhagia (HP:0000132)2.38619740
70Abnormality of pyrimidine metabolism (HP:0004353)2.36648841
71Abnormality of nucleobase metabolism (HP:0010932)2.35359244
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.34910003
73Abnormality of purine metabolism (HP:0004352)2.34714445
74Vertebral compression fractures (HP:0002953)2.33946566
75Turricephaly (HP:0000262)2.29780186
76Gingivitis (HP:0000230)2.28022954
77Mitral stenosis (HP:0001718)2.24599327
78Amyloidosis (HP:0011034)2.23040909
79Irritability (HP:0000737)2.21356661
80Interstitial pulmonary disease (HP:0006530)2.20972721
81Lower limb hyperreflexia (HP:0002395)2.20951197
82Alkalosis (HP:0001948)2.20256193
83Purpura (HP:0000979)2.20129194
84Vascular calcification (HP:0004934)2.20099414
85Glomerulonephritis (HP:0000099)2.18147988
86Abnormal enzyme/coenzyme activity (HP:0012379)2.17207972
87Supranuclear gaze palsy (HP:0000605)2.17057033
88Abnormality of proline metabolism (HP:0010907)2.14784988
89Hydroxyprolinuria (HP:0003080)2.14784988
90Rickets (HP:0002748)2.14623534
91Neuronal loss in central nervous system (HP:0002529)2.14564270
92Delayed CNS myelination (HP:0002188)2.14543833
93Progressive neurologic deterioration (HP:0002344)2.13609406
94Global brain atrophy (HP:0002283)2.12846764
95Metabolic acidosis (HP:0001942)2.11845955
96Status epilepticus (HP:0002133)2.10857105
97Nuclear cataract (HP:0100018)2.10776233
98Growth hormone excess (HP:0000845)2.10520556
99Sensorimotor neuropathy (HP:0007141)2.10074572
100Polycythemia (HP:0001901)2.09742116
101Abnormality of serum amino acid levels (HP:0003112)2.09476424
102Pancreatitis (HP:0001733)2.08748060
103Apathy (HP:0000741)2.05511592
104Osteolytic defects of the hand bones (HP:0009699)2.03837289
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.03837289
106Opisthotonus (HP:0002179)2.02724468
107Asymmetric septal hypertrophy (HP:0001670)2.02637850
108Diminished motivation (HP:0000745)2.02591627
109Abnormality of the vasculature of the conjunctiva (HP:0008054)2.01290826
110Abnormality of the distal phalanges of the toes (HP:0010182)2.01126775
111Abnormality of alkaline phosphatase activity (HP:0004379)2.00647799
112Obstructive sleep apnea (HP:0002870)2.00273853
113Urinary glycosaminoglycan excretion (HP:0003541)1.99657117
114Mucopolysacchariduria (HP:0008155)1.99657117
115Nephritis (HP:0000123)1.99483372
116Basal ganglia calcification (HP:0002135)1.97696597
117Progressive inability to walk (HP:0002505)1.96162864
118Hypochromic anemia (HP:0001931)1.96064934
119Metaphyseal irregularity (HP:0003025)1.95697654
120Distal lower limb muscle weakness (HP:0009053)1.93691014
121Retinal atrophy (HP:0001105)1.93521572
122Hemorrhage of the eye (HP:0011885)1.92509933
123Hand muscle atrophy (HP:0009130)1.92507507
124Pigmentary retinal degeneration (HP:0001146)1.92346854
125Premature loss of primary teeth (HP:0006323)1.91587243
126Acute hepatic failure (HP:0006554)1.91050219
127Lethargy (HP:0001254)1.91017732
128Protuberant abdomen (HP:0001538)1.89527580
129Hyperinsulinemic hypoglycemia (HP:0000825)1.89225095
130Pathologic fracture (HP:0002756)1.88666917
131Malnutrition (HP:0004395)1.88641522
132Abnormality of polysaccharide metabolism (HP:0011012)1.88323217
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88323217
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88323217
135Tetraparesis (HP:0002273)1.88237036
136Gout (HP:0001997)1.86652733
137Pustule (HP:0200039)1.86074564
138Joint swelling (HP:0001386)1.85261331
139Orchitis (HP:0100796)1.84616727
140Cardiovascular calcification (HP:0011915)1.83313684
141Fair hair (HP:0002286)1.82838709
142Skin nodule (HP:0200036)1.82629799
143Bone pain (HP:0002653)1.81269639
144Muscle fiber splitting (HP:0003555)1.81238211
145Dementia (HP:0000726)1.80278154
146Upper motor neuron abnormality (HP:0002127)1.80042543
147Recurrent skin infections (HP:0001581)1.79642319
148Elevated alkaline phosphatase (HP:0003155)1.79550429
149Hepatocellular carcinoma (HP:0001402)1.78177373
150Pulmonary infiltrates (HP:0002113)1.77830591
151Osteomalacia (HP:0002749)1.77346375
152Abnormality of the periventricular white matter (HP:0002518)1.75929423
153Peripheral demyelination (HP:0011096)1.74706762
154Distal upper limb amyotrophy (HP:0007149)1.73935507
155Upper limb amyotrophy (HP:0009129)1.73935507
156Pulmonary embolism (HP:0002204)1.72387621
157Segmental peripheral demyelination/remyelination (HP:0003481)1.71667190
158Myositis (HP:0100614)1.71273911
159Hypophosphatemia (HP:0002148)1.69271963
160Renal cortical cysts (HP:0000803)1.69022679
161Oligomenorrhea (HP:0000876)1.68344344
162J-shaped sella turcica (HP:0002680)1.68127026
163Flat acetabular roof (HP:0003180)1.66739052
164Mediastinal lymphadenopathy (HP:0100721)1.65525819
165Urinary incontinence (HP:0000020)1.65339636
166Conjunctival telangiectasia (HP:0000524)1.65333639
167Difficulty running (HP:0009046)1.64477434
168Hyperparathyroidism (HP:0000843)1.63545471
169Esophageal varix (HP:0002040)1.63392805
170Retrobulbar optic neuritis (HP:0100654)1.62372556
171Optic neuritis (HP:0100653)1.62372556
172Mucosal telangiectasiae (HP:0100579)1.59997854
173Cerebral aneurysm (HP:0004944)1.57461798
174Spinal muscular atrophy (HP:0007269)1.56674060
175Abnormality of calcium-phosphate metabolism (HP:0100530)1.55844621
176Vascular tortuosity (HP:0004948)1.54847653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.55124945
2MAPK153.30081309
3INSRR2.57621001
4BLK2.55423876
5MAP3K22.49478997
6MAP3K142.46773484
7MAP3K62.44370237
8ACVR1B2.36015302
9ICK2.18335034
10BCKDK2.15388557
11TGFBR22.09337178
12AKT32.05200288
13RIPK11.88425756
14CAMKK21.86943864
15MATK1.86581223
16TAOK31.82267335
17FRK1.79146211
18DDR21.74939583
19YES11.73818310
20SIK11.72922702
21MAP3K11.65251738
22STK241.62342878
23MAP3K31.58808193
24JAK11.56913877
25FGFR41.53331739
26TXK1.52769441
27MAP3K111.51706751
28TYK21.50688081
29IKBKE1.49776207
30PRKD21.49576782
31MAP2K71.44120750
32PRPF4B1.43585023
33SGK31.42084950
34CSK1.39612765
35BMX1.39237219
36KSR21.36556065
37SGK21.33534526
38ZAP701.32364736
39IRAK31.31384928
40BMPR21.27771653
41MAP3K121.23686408
42FES1.20477028
43IKBKB1.19735245
44MAP2K41.18736110
45FGFR31.14277159
46MAP3K131.13883641
47MAPK111.13880541
48DYRK1B1.13774604
49FGR1.13616766
50TNK21.13575837
51CAMKK11.13419328
52DAPK11.12888661
53PDPK11.08549154
54CSF1R1.08184599
55UHMK11.05379663
56ARAF1.04488897
57JAK21.00136121
58SGK2230.99865084
59SGK4940.99865084
60PRKAA20.99355404
61NLK0.99229719
62MOS0.98906162
63GRK70.94567903
64PDK10.92736011
65NTRK30.92127697
66TBK10.91435066
67TAOK10.88882431
68EPHB10.88380540
69JAK30.87616117
70PRKAA10.87336983
71IRAK40.85715774
72ERBB40.82298458
73CAMK2G0.81840239
74PRKCH0.81789549
75DAPK20.81493482
76EPHA30.81031909
77MAP2K30.80557703
78PDGFRA0.80276258
79PIK3CG0.79921466
80GSK3A0.79155195
81PRKG20.78223220
82TIE10.77622101
83PDGFRB0.77517898
84GRK10.76308683
85RPS6KB10.75923655
86TRIB30.75272543
87SIK30.73899388
88STK380.73817763
89FER0.72831196
90RIPK40.72632480
91CHUK0.72561725
92KSR10.71478209
93PIM10.71223037
94SGK10.70935525
95MUSK0.70905671
96RPS6KA20.70880300
97ERN10.69904255
98CAMK1G0.69688598
99SIK20.67670901
100STK110.66381429
101NEK90.66163196
102MARK20.66053945
103PHKG20.66039173
104PHKG10.66039173
105HCK0.65809628
106CASK0.65329102
107TRPM70.64846590
108HIPK20.64489468
109MAPK120.64448472
110ADRBK20.63147807
111RET0.62877060
112CDC42BPA0.62580541
113NEK60.62136951
114PIM20.61828658
115IRAK10.61452907
116RPS6KA60.60002617
117MAP3K90.59799307
118RPS6KC10.59718645
119RPS6KL10.59718645
120PKN10.55746127
121MYLK0.54217610
122CDK60.53157705
123PRKACG0.53057625
124PTK2B0.52770921
125PTK60.52169594
126BMPR1B0.51838249
127MAPK70.51223027
128IRAK20.50931869
129SYK0.50202527
130GRK50.49166485
131TAOK20.48597574
132LCK0.48318330
133TESK10.47730235
134BTK0.47511399
135TNIK0.47108562
136LATS20.46997118
137LMTK20.46888907
138EPHA40.46789487
139MST1R0.46319024
140MAP3K70.46094514
141PRKCZ0.45374017
142CAMK2A0.45103620
143LYN0.43846083
144CAMK1D0.43562494
145ABL20.43368431
146TTN0.42553145
147STK30.42511636
148SCYL20.42232876
149MAP4K10.41213573
150MAPK40.41014470
151MAP3K40.40523084
152OXSR10.40489655
153FYN0.40317423

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03843144
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.59276683
3Nitrogen metabolism_Homo sapiens_hsa009103.27162240
4Arginine biosynthesis_Homo sapiens_hsa002202.91889271
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73702609
6Other glycan degradation_Homo sapiens_hsa005112.51425965
7Tryptophan metabolism_Homo sapiens_hsa003802.46833444
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38780445
9Complement and coagulation cascades_Homo sapiens_hsa046102.38211736
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.37225186
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30719270
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15879051
13Fatty acid degradation_Homo sapiens_hsa000712.03802553
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.00267108
15Peroxisome_Homo sapiens_hsa041461.99088371
16Osteoclast differentiation_Homo sapiens_hsa043801.93189162
17Histidine metabolism_Homo sapiens_hsa003401.89227076
18Fatty acid metabolism_Homo sapiens_hsa012121.88176245
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88127798
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.86066528
21Leishmaniasis_Homo sapiens_hsa051401.83543308
22Fatty acid biosynthesis_Homo sapiens_hsa000611.82612120
23Butanoate metabolism_Homo sapiens_hsa006501.77320656
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73283434
25Staphylococcus aureus infection_Homo sapiens_hsa051501.71497879
26beta-Alanine metabolism_Homo sapiens_hsa004101.71477948
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71146892
28Propanoate metabolism_Homo sapiens_hsa006401.68745015
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.67306602
30ABC transporters_Homo sapiens_hsa020101.65294907
31Chemical carcinogenesis_Homo sapiens_hsa052041.61807790
32PPAR signaling pathway_Homo sapiens_hsa033201.61132955
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.59881321
34Phenylalanine metabolism_Homo sapiens_hsa003601.59770088
35Pertussis_Homo sapiens_hsa051331.58051292
36Caffeine metabolism_Homo sapiens_hsa002321.56476623
37Tuberculosis_Homo sapiens_hsa051521.55410300
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53524629
39Retinol metabolism_Homo sapiens_hsa008301.53146628
40Phagosome_Homo sapiens_hsa041451.50238425
41Starch and sucrose metabolism_Homo sapiens_hsa005001.38170462
42Bile secretion_Homo sapiens_hsa049761.35708189
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.35001117
44Fatty acid elongation_Homo sapiens_hsa000621.32083801
45Sulfur metabolism_Homo sapiens_hsa009201.28880564
46Asthma_Homo sapiens_hsa053101.27551584
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25543822
48Toxoplasmosis_Homo sapiens_hsa051451.24841677
49Tyrosine metabolism_Homo sapiens_hsa003501.24811610
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22340557
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22061707
52Dorso-ventral axis formation_Homo sapiens_hsa043201.19433968
53Selenocompound metabolism_Homo sapiens_hsa004501.17916031
54Steroid biosynthesis_Homo sapiens_hsa001001.15721957
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15200701
56Vitamin digestion and absorption_Homo sapiens_hsa049771.06733225
57Hematopoietic cell lineage_Homo sapiens_hsa046401.05233944
58Malaria_Homo sapiens_hsa051441.05092182
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04782070
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03718449
61Arginine and proline metabolism_Homo sapiens_hsa003301.03302451
62B cell receptor signaling pathway_Homo sapiens_hsa046621.02872433
63Chemokine signaling pathway_Homo sapiens_hsa040621.02665738
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01808142
65Mineral absorption_Homo sapiens_hsa049780.98022011
66Amoebiasis_Homo sapiens_hsa051460.97118091
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94901790
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92363526
69Renin secretion_Homo sapiens_hsa049240.92257585
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90648853
71Prolactin signaling pathway_Homo sapiens_hsa049170.85262508
72TNF signaling pathway_Homo sapiens_hsa046680.84296511
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.81752085
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80276586
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78439006
76Folate biosynthesis_Homo sapiens_hsa007900.76790296
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75531834
78Type II diabetes mellitus_Homo sapiens_hsa049300.75150427
79Pyruvate metabolism_Homo sapiens_hsa006200.74922615
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.74228218
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.74110557
82Sphingolipid metabolism_Homo sapiens_hsa006000.74019081
83Platelet activation_Homo sapiens_hsa046110.73639786
84Viral myocarditis_Homo sapiens_hsa054160.73398582
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.73312854
86GnRH signaling pathway_Homo sapiens_hsa049120.72454365
87Salmonella infection_Homo sapiens_hsa051320.72434429
88Fat digestion and absorption_Homo sapiens_hsa049750.72302090
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72288364
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71785159
91Influenza A_Homo sapiens_hsa051640.71263185
92Glycerolipid metabolism_Homo sapiens_hsa005610.71236077
93Legionellosis_Homo sapiens_hsa051340.70874231
94Lysine degradation_Homo sapiens_hsa003100.70799349
95mTOR signaling pathway_Homo sapiens_hsa041500.69742912
96Hepatitis C_Homo sapiens_hsa051600.69636199
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.67567600
98Endocytosis_Homo sapiens_hsa041440.67065115
99Vibrio cholerae infection_Homo sapiens_hsa051100.66589015
100Biosynthesis of amino acids_Homo sapiens_hsa012300.65450449
101Long-term potentiation_Homo sapiens_hsa047200.65091774
102Antigen processing and presentation_Homo sapiens_hsa046120.65042193
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64995746
104Renal cell carcinoma_Homo sapiens_hsa052110.64006096
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.61405483
106Acute myeloid leukemia_Homo sapiens_hsa052210.60973386
107Inositol phosphate metabolism_Homo sapiens_hsa005620.60502006
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59770930
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58722645
110Sulfur relay system_Homo sapiens_hsa041220.58519564
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55186995
112Renin-angiotensin system_Homo sapiens_hsa046140.55142762
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.55074064
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54478438
115Estrogen signaling pathway_Homo sapiens_hsa049150.52808930
116Fructose and mannose metabolism_Homo sapiens_hsa000510.52792914
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52292539
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51347662
119VEGF signaling pathway_Homo sapiens_hsa043700.50602594
120Prion diseases_Homo sapiens_hsa050200.50473972
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50005600
122T cell receptor signaling pathway_Homo sapiens_hsa046600.47550747
123Linoleic acid metabolism_Homo sapiens_hsa005910.47230926
124Vitamin B6 metabolism_Homo sapiens_hsa007500.47009939
125Insulin signaling pathway_Homo sapiens_hsa049100.46639987
126Allograft rejection_Homo sapiens_hsa053300.46028346
127FoxO signaling pathway_Homo sapiens_hsa040680.44619701
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44083777
129Circadian rhythm_Homo sapiens_hsa047100.42685913
130Measles_Homo sapiens_hsa051620.40138459
131Proteoglycans in cancer_Homo sapiens_hsa052050.39040064
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38391790
133Pancreatic cancer_Homo sapiens_hsa052120.38282664
134Autoimmune thyroid disease_Homo sapiens_hsa053200.38127639
135Carbon metabolism_Homo sapiens_hsa012000.37757697
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.36041925
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35107212
138GABAergic synapse_Homo sapiens_hsa047270.34266495
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.33941232
140Graft-versus-host disease_Homo sapiens_hsa053320.33844883
141Metabolic pathways_Homo sapiens_hsa011000.33838068
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.31368671
143African trypanosomiasis_Homo sapiens_hsa051430.28815202
144Type I diabetes mellitus_Homo sapiens_hsa049400.28105166
145Galactose metabolism_Homo sapiens_hsa000520.23338951
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22449211
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.22034040
148Insulin resistance_Homo sapiens_hsa049310.20769633
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20526917
150Insulin secretion_Homo sapiens_hsa049110.18381390
151Synaptic vesicle cycle_Homo sapiens_hsa047210.17314470
152Glutathione metabolism_Homo sapiens_hsa004800.17093348
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16108740
154Pentose phosphate pathway_Homo sapiens_hsa000300.15794995
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15449727
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15282224
157Lysosome_Homo sapiens_hsa041420.15036375
158Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14854330
159Taste transduction_Homo sapiens_hsa047420.14306596
160Collecting duct acid secretion_Homo sapiens_hsa049660.13480956
161Rheumatoid arthritis_Homo sapiens_hsa053230.13134239
162Olfactory transduction_Homo sapiens_hsa047400.12928627
163Primary immunodeficiency_Homo sapiens_hsa053400.11742276
164Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10996907
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09411609
166Glucagon signaling pathway_Homo sapiens_hsa049220.09075553
167Ovarian steroidogenesis_Homo sapiens_hsa049130.07835675
168Arachidonic acid metabolism_Homo sapiens_hsa005900.06533704

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