CREB3L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.17311623
2angiotensin maturation (GO:0002003)7.88076521
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.28695739
4L-phenylalanine catabolic process (GO:0006559)7.28695739
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.98143010
6L-phenylalanine metabolic process (GO:0006558)6.98079993
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.98079993
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.75360119
9aromatic amino acid family catabolic process (GO:0009074)6.57080229
10drug metabolic process (GO:0017144)6.08368101
11tryptophan catabolic process (GO:0006569)5.96310457
12indole-containing compound catabolic process (GO:0042436)5.96310457
13indolalkylamine catabolic process (GO:0046218)5.96310457
14kynurenine metabolic process (GO:0070189)5.86746032
15exogenous drug catabolic process (GO:0042738)5.85705431
16fat-soluble vitamin biosynthetic process (GO:0042362)5.79789499
17bile acid biosynthetic process (GO:0006699)5.79117715
18high-density lipoprotein particle remodeling (GO:0034375)5.77248810
19NADH metabolic process (GO:0006734)5.69863682
20urea metabolic process (GO:0019627)5.65943480
21urea cycle (GO:0000050)5.65943480
22glyoxylate metabolic process (GO:0046487)5.61721520
23tryptophan metabolic process (GO:0006568)5.61249736
24hormone catabolic process (GO:0042447)5.61178896
25alpha-linolenic acid metabolic process (GO:0036109)5.58418377
26negative regulation of fibrinolysis (GO:0051918)5.48396286
27intestinal absorption (GO:0050892)5.38065281
28regulation of fibrinolysis (GO:0051917)5.28234611
29regulation of cholesterol esterification (GO:0010872)5.25127558
30regulation of triglyceride catabolic process (GO:0010896)5.22053823
31cysteine metabolic process (GO:0006534)5.21820453
32regulation of protein activation cascade (GO:2000257)5.21266234
33peptidyl-glutamic acid carboxylation (GO:0017187)5.21118902
34protein carboxylation (GO:0018214)5.21118902
35nitrogen cycle metabolic process (GO:0071941)5.19637441
36omega-hydroxylase P450 pathway (GO:0097267)5.15074580
37reverse cholesterol transport (GO:0043691)5.14889750
38complement activation, alternative pathway (GO:0006957)5.14038990
39sulfur amino acid catabolic process (GO:0000098)5.13154193
40fructose metabolic process (GO:0006000)5.12152666
41phospholipid efflux (GO:0033700)5.00455921
42bile acid metabolic process (GO:0008206)4.98905944
43plasma lipoprotein particle remodeling (GO:0034369)4.97786151
44protein-lipid complex remodeling (GO:0034368)4.97786151
45macromolecular complex remodeling (GO:0034367)4.97786151
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92763924
47serine family amino acid catabolic process (GO:0009071)4.92472936
48lipoprotein transport (GO:0042953)4.90061184
49regulation of complement activation (GO:0030449)4.86187134
50aromatic amino acid family metabolic process (GO:0009072)4.77447525
51negative regulation of sterol transport (GO:0032372)4.76677474
52negative regulation of cholesterol transport (GO:0032375)4.76677474
53acylglycerol homeostasis (GO:0055090)4.73937294
54triglyceride homeostasis (GO:0070328)4.73937294
55regulation of guanylate cyclase activity (GO:0031282)4.68090606
56homocysteine metabolic process (GO:0050667)4.65679073
57tyrosine metabolic process (GO:0006570)4.60499150
58cholesterol efflux (GO:0033344)4.55206928
59diacylglycerol metabolic process (GO:0046339)4.54965415
60amino-acid betaine metabolic process (GO:0006577)4.54217181
61lysine catabolic process (GO:0006554)4.48623694
62lysine metabolic process (GO:0006553)4.48623694
63plasma lipoprotein particle clearance (GO:0034381)4.46610774
64alpha-amino acid catabolic process (GO:1901606)4.46517840
65bile acid and bile salt transport (GO:0015721)4.41755686
66plasma lipoprotein particle assembly (GO:0034377)4.35556276
67cellular ketone body metabolic process (GO:0046950)4.34880556
68alkaloid metabolic process (GO:0009820)4.27300577
69positive regulation of triglyceride lipase activity (GO:0061365)4.25982389
70positive regulation of lipoprotein lipase activity (GO:0051006)4.25982389
71coenzyme catabolic process (GO:0009109)4.25562867
72glycine metabolic process (GO:0006544)4.24868692
73indolalkylamine metabolic process (GO:0006586)4.22614147
74positive regulation of fatty acid biosynthetic process (GO:0045723)4.22419769
75cellular glucuronidation (GO:0052695)4.20892130
76imidazole-containing compound metabolic process (GO:0052803)4.15789564
77glutamate metabolic process (GO:0006536)4.15754542
78drug catabolic process (GO:0042737)4.15744630
79amine catabolic process (GO:0009310)4.11743483
80cellular biogenic amine catabolic process (GO:0042402)4.11743483
81cellular amino acid catabolic process (GO:0009063)4.11086334
82regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.11067024
83endocrine process (GO:0050886)4.11067024
84regulation of systemic arterial blood pressure by hormone (GO:0001990)4.11067024
85intestinal cholesterol absorption (GO:0030299)4.09754802
86serine family amino acid metabolic process (GO:0009069)4.04739379
87benzene-containing compound metabolic process (GO:0042537)4.01168268
88very-low-density lipoprotein particle assembly (GO:0034379)3.98786585
89arginine metabolic process (GO:0006525)3.97247552
90cholesterol homeostasis (GO:0042632)3.96046199
91cellular modified amino acid catabolic process (GO:0042219)3.95574748
92low-density lipoprotein particle remodeling (GO:0034374)3.94674419
93ethanol oxidation (GO:0006069)3.93783679
94protein-lipid complex assembly (GO:0065005)3.92226586
95serine family amino acid biosynthetic process (GO:0009070)3.91999584
96positive regulation of lipid catabolic process (GO:0050996)3.91759255
97regulation of bile acid biosynthetic process (GO:0070857)3.90171716
98fibrinolysis (GO:0042730)3.90168059
99dicarboxylic acid biosynthetic process (GO:0043650)3.89637184
100sterol homeostasis (GO:0055092)3.89597543
101plasma lipoprotein particle organization (GO:0071827)3.83884288
102phospholipid homeostasis (GO:0055091)3.82201830
103aldehyde catabolic process (GO:0046185)3.81780238
104proline metabolic process (GO:0006560)3.79533508
105phenylpropanoid metabolic process (GO:0009698)3.78347931
106regulation of cholesterol homeostasis (GO:2000188)3.77550111
107ketone body metabolic process (GO:1902224)3.76047031
108blood coagulation, intrinsic pathway (GO:0007597)3.74605554
109negative regulation of lipase activity (GO:0060192)3.74452939
110lipoprotein metabolic process (GO:0042157)3.73704249
111uronic acid metabolic process (GO:0006063)3.73239120
112glucuronate metabolic process (GO:0019585)3.73239120
113flavonoid metabolic process (GO:0009812)3.71273476
114acute-phase response (GO:0006953)3.67113002
115cofactor catabolic process (GO:0051187)3.66612157
116complement activation, classical pathway (GO:0006958)3.66398239
117organic acid catabolic process (GO:0016054)3.62836774
118carboxylic acid catabolic process (GO:0046395)3.62836774
119protein-lipid complex subunit organization (GO:0071825)3.62058790
120regulation of systemic arterial blood pressure (GO:0003073)3.61837803
121protein activation cascade (GO:0072376)3.61194521
122complement activation (GO:0006956)3.60402770
123glutamine family amino acid biosynthetic process (GO:0009084)3.58052912
124renal system process involved in regulation of blood volume (GO:0001977)3.57240955
125cytolysis (GO:0019835)3.56586103
126drug transport (GO:0015893)3.49951661
127positive regulation of triglyceride metabolic process (GO:0090208)3.47911518
128negative regulation of hemostasis (GO:1900047)3.47011451
129negative regulation of blood coagulation (GO:0030195)3.47011451
130renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.46564608
131drug transmembrane transport (GO:0006855)3.42995735
132positive regulation of guanylate cyclase activity (GO:0031284)3.41824723
133oxidative demethylation (GO:0070989)3.41392696
134heme transport (GO:0015886)3.34884293
135ethanol metabolic process (GO:0006067)3.32899998
136peptide catabolic process (GO:0043171)3.26880298
137peptide hormone processing (GO:0016486)3.22735947
138vitamin biosynthetic process (GO:0009110)3.21753882
139oxaloacetate metabolic process (GO:0006107)3.20795056
140vitamin transport (GO:0051180)3.20650262
141negative regulation of coagulation (GO:0050819)3.20308047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.31064369
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20323556
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.95597518
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.47539036
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23446690
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.02587137
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81952445
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04462773
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.90278920
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.25540115
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.20534816
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11489528
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02855553
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8558513
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93619006
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81415001
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62396557
18CLOCK_20551151_ChIP-Seq_293T_Human1.58268812
19HTT_18923047_ChIP-ChIP_STHdh_Human1.51436485
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46301522
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33769555
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26490356
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.25731295
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22101584
25* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16021336
26SA1_27219007_Chip-Seq_Bcells_Human1.16017558
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14843043
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14691522
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14057535
30* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13267041
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13219882
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11311927
33BCL6_27268052_Chip-Seq_Bcells_Human1.09335681
34* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08331435
35JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06699634
36CTCF_27219007_Chip-Seq_Bcells_Human1.06398209
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05981851
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05521776
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.04770344
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00680737
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00668984
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00581551
43* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99799171
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97988194
45* GATA4_25053715_ChIP-Seq_YYC3_Human0.95895051
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91973845
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91392036
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87077764
49IRF8_22096565_ChIP-ChIP_GC-B_Human0.84991926
50RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82729496
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82503934
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81203176
53EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81031583
54E2F1_20622854_ChIP-Seq_HELA_Human0.80861132
55AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80144491
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79931898
57CDX2_20551321_ChIP-Seq_CACO-2_Human0.79568878
58NANOG_20526341_ChIP-Seq_ESCs_Human0.79144206
59KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78949218
60PHF8_20622854_ChIP-Seq_HELA_Human0.78135820
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77690480
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.77667023
63P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77223969
64SOX2_21211035_ChIP-Seq_LN229_Human0.76932897
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75820808
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75532627
67CTCF_20526341_ChIP-Seq_ESCs_Human0.75488468
68* RARA_24833708_ChIP-Seq_LIVER_Mouse0.74708353
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73867505
70GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73177684
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73147886
72P68_20966046_ChIP-Seq_HELA_Human0.73082738
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.73044651
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72726568
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72717567
76CREB1_26743006_Chip-Seq_LNCaP_Human0.72256986
77* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72103557
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71500128
79SMC4_20622854_ChIP-Seq_HELA_Human0.71003117
80* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70818264
81ZNF263_19887448_ChIP-Seq_K562_Human0.70646464
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70454352
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70224687
84ETS1_21867929_ChIP-Seq_TH2_Mouse0.69799047
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69685146
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69582079
87OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69251081
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.68412398
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65843518
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63805665
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.63600475
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62309725
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61558763
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61558763
95CEBPB_22108803_ChIP-Seq_LS180_Human0.59703011
96LXR_22292898_ChIP-Seq_THP-1_Human0.58641103
97EGR1_19032775_ChIP-ChIP_M12_Human0.58110031
98GATA6_25053715_ChIP-Seq_YYC3_Human0.56571378
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55340367
100FOXA1_25552417_ChIP-Seq_VCAP_Human0.55319356
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55194407
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54725293
103AR_20517297_ChIP-Seq_VCAP_Human0.53834314
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.53794683
105* MYC_19915707_ChIP-ChIP_AK7_Human0.52209780
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52134051
107STAT1_17558387_ChIP-Seq_HELA_Human0.50582677
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.49571674
109ESET_19884257_ChIP-Seq_ESCs_Mouse0.49329495
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.49150724
111GATA2_19941826_ChIP-Seq_K562_Human0.48418095
112CBP_21632823_ChIP-Seq_H3396_Human0.48360992
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47362739
114P53_21459846_ChIP-Seq_SAOS-2_Human0.47336152
115GATA1_19941826_ChIP-Seq_K562_Human0.46632126
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.46412012
117SOX2_20726797_ChIP-Seq_SW620_Human0.46002308
118TAF2_19829295_ChIP-Seq_ESCs_Human0.45423597
119PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45415252
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45261857
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.44743028
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43281910
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.42127431
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40558243
125* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39659637
126BCAT_22108803_ChIP-Seq_LS180_Human0.38733010
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.37780751
128SPI1_26923725_Chip-Seq_HPCs_Mouse0.37437780
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.37154716
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.35711215
131CDX2_22108803_ChIP-Seq_LS180_Human0.35690974
132BCOR_27268052_Chip-Seq_Bcells_Human0.35567544
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35235480
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.34889608
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.34537810
136* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34426424
137ERG_20517297_ChIP-Seq_VCAP_Human0.34129533
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.33952617
139* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33575321
140RACK7_27058665_Chip-Seq_MCF-7_Human0.33429121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25255833
2MP0005360_urolithiasis7.87842982
3MP0005085_abnormal_gallbladder_physiolo6.38294209
4MP0005365_abnormal_bile_salt6.03531108
5MP0008875_abnormal_xenobiotic_pharmacok5.09012461
6MP0003806_abnormal_nucleotide_metabolis4.09746322
7MP0003252_abnormal_bile_duct4.01868422
8MP0010329_abnormal_lipoprotein_level3.67735439
9MP0009840_abnormal_foam_cell3.61425636
10MP0001666_abnormal_nutrient_absorption3.00187727
11MP0003183_abnormal_peptide_metabolism2.90708956
12MP0005083_abnormal_biliary_tract2.89843717
13MP0005332_abnormal_amino_acid2.68734512
14MP0003195_calcinosis2.59811709
15MP0003191_abnormal_cellular_cholesterol2.39196913
16MP0009379_abnormal_foot_pigmentation2.25014948
17MP0004019_abnormal_vitamin_homeostasis2.18428026
18MP0000609_abnormal_liver_physiology2.14750316
19MP0002118_abnormal_lipid_homeostasis2.09734054
20MP0002138_abnormal_hepatobiliary_system1.84746799
21MP0003868_abnormal_feces_composition1.84564049
22MP0005319_abnormal_enzyme/_coenzyme1.78613443
23MP0010155_abnormal_intestine_physiology1.76327130
24MP0004147_increased_porphyrin_level1.73785555
25MP0009697_abnormal_copulation1.66408223
26MP0001764_abnormal_homeostasis1.64844973
27MP0005409_darkened_coat_color1.63762319
28MP0005584_abnormal_enzyme/coenzyme_acti1.51160451
29MP0005451_abnormal_body_composition1.48668089
30MP0003011_delayed_dark_adaptation1.30311476
31MP0003879_abnormal_hair_cell1.27847810
32MP0003656_abnormal_erythrocyte_physiolo1.23902271
33MP0009643_abnormal_urine_homeostasis1.22708685
34MP0003705_abnormal_hypodermis_morpholog1.19377832
35MP0000598_abnormal_liver_morphology1.14916378
36MP0001664_abnormal_digestion1.14486256
37MP0003866_abnormal_defecation1.14224220
38MP0003186_abnormal_redox_activity1.12915896
39MP0002254_reproductive_system_inflammat1.11878005
40MP0000604_amyloidosis1.08770416
41MP0000678_abnormal_parathyroid_gland1.08308045
42MP0005647_abnormal_sex_gland1.04846697
43MP0009764_decreased_sensitivity_to1.03450396
44MP0000538_abnormal_urinary_bladder1.02057397
45MP0009763_increased_sensitivity_to0.97030462
46MP0005084_abnormal_gallbladder_morpholo0.92154234
47MP0005636_abnormal_mineral_homeostasis0.91066560
48MP0010368_abnormal_lymphatic_system0.89049228
49MP0000490_abnormal_crypts_of0.87429044
50MP0000477_abnormal_intestine_morphology0.86265452
51* MP0009642_abnormal_blood_homeostasis0.86024715
52MP0001765_abnormal_ion_homeostasis0.85793472
53* MP0008469_abnormal_protein_level0.84128970
54MP0005376_homeostasis/metabolism_phenot0.80817468
55MP0005408_hypopigmentation0.80176986
56MP0002876_abnormal_thyroid_physiology0.79095441
57MP0009765_abnormal_xenobiotic_induced0.78616089
58MP0002078_abnormal_glucose_homeostasis0.76678730
59MP0005058_abnormal_lysosome_morphology0.76082829
60MP0006036_abnormal_mitochondrial_physio0.75715899
61MP0002971_abnormal_brown_adipose0.70990931
62MP0004858_abnormal_nervous_system0.70667488
63MP0009053_abnormal_anal_canal0.69526385
64MP0005670_abnormal_white_adipose0.69321525
65MP0010352_gastrointestinal_tract_polyps0.68508696
66MP0005266_abnormal_metabolism0.68170066
67MP0005334_abnormal_fat_pad0.68159346
68MP0009785_altered_susceptibility_to0.67694394
69MP0000462_abnormal_digestive_system0.67276835
70MP0005220_abnormal_exocrine_pancreas0.65039067
71MP0005448_abnormal_energy_balance0.64780590
72MP0002822_catalepsy0.63526532
73MP0005535_abnormal_body_temperature0.63381209
74MP0001663_abnormal_digestive_system0.62919267
75MP0001188_hyperpigmentation0.60205781
76MP0003690_abnormal_glial_cell0.59811124
77MP0004130_abnormal_muscle_cell0.59527961
78MP0003329_amyloid_beta_deposits0.58855002
79MP0000566_synostosis0.58724430
80MP0001756_abnormal_urination0.56728749
81MP0000639_abnormal_adrenal_gland0.56266853
82MP0004270_analgesia0.54810931
83MP0004043_abnormal_pH_regulation0.54682116
84MP0001661_extended_life_span0.54398999
85MP0005464_abnormal_platelet_physiology0.54146011
86MP0006035_abnormal_mitochondrial_morpho0.53966725
87MP0003718_maternal_effect0.52763317
88MP0005381_digestive/alimentary_phenotyp0.50687225
89MP0001501_abnormal_sleep_pattern0.49631543
90MP0002089_abnormal_postnatal_growth/wei0.49414935
91MP0003638_abnormal_response/metabolism_0.48392218
92MP0005395_other_phenotype0.47155474
93MP0004264_abnormal_extraembryonic_tissu0.46630819
94MP0002136_abnormal_kidney_physiology0.46294698
95MP0001873_stomach_inflammation0.45507302
96MP0002098_abnormal_vibrissa_morphology0.45071832
97MP0008873_increased_physiological_sensi0.44185326
98MP0002249_abnormal_larynx_morphology0.42950895
99MP0005166_decreased_susceptibility_to0.42129372
100MP0008874_decreased_physiological_sensi0.41963315
101MP0002796_impaired_skin_barrier0.41520821
102MP0003436_decreased_susceptibility_to0.41093035
103MP0005025_abnormal_response_to0.40980797
104MP0008872_abnormal_physiological_respon0.40673648
105MP0004782_abnormal_surfactant_physiolog0.40509256
106MP0003953_abnormal_hormone_level0.40433688
107MP0002928_abnormal_bile_duct0.40250621
108MP0009333_abnormal_splenocyte_physiolog0.39705717
109MP0010234_abnormal_vibrissa_follicle0.38703899
110MP0005248_abnormal_Harderian_gland0.38536885
111MP0003724_increased_susceptibility_to0.37315877
112MP0003075_altered_response_to0.37228397
113MP0005666_abnormal_adipose_tissue0.36103366
114MP0009115_abnormal_fat_cell0.36034011
115MP0000579_abnormal_nail_morphology0.35993575
116MP0004381_abnormal_hair_follicle0.34758829
117MP0009384_cardiac_valve_regurgitation0.34541093
118MP0008260_abnormal_autophagy0.34402206
119MP0002166_altered_tumor_susceptibility0.33683020
120MP0000249_abnormal_blood_vessel0.33380013
121MP0002837_dystrophic_cardiac_calcinosis0.33329147
122MP0000230_abnormal_systemic_arterial0.32134606
123MP0004883_abnormal_blood_vessel0.31337402
124MP0006082_CNS_inflammation0.31181056
125MP0009672_abnormal_birth_weight0.30657011
126MP0001243_abnormal_dermal_layer0.30493050
127MP0001881_abnormal_mammary_gland0.29926543
128MP0002970_abnormal_white_adipose0.27811304
129* MP0001845_abnormal_inflammatory_respons0.25921744
130MP0001853_heart_inflammation0.25677266
131MP0000427_abnormal_hair_cycle0.25058496
132MP0002132_abnormal_respiratory_system0.24392572
133MP0005167_abnormal_blood-brain_barrier0.24283982

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.22843108
2Deep venous thrombosis (HP:0002625)7.19114265
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.15818561
4Hypobetalipoproteinemia (HP:0003563)6.80687856
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64482361
6Prolonged partial thromboplastin time (HP:0003645)6.39559203
7Xanthomatosis (HP:0000991)6.36689363
8Hyperlipoproteinemia (HP:0010980)5.44197595
9Complement deficiency (HP:0004431)5.23014600
10Hypolipoproteinemia (HP:0010981)5.02592110
11Joint hemorrhage (HP:0005261)4.63735688
12Hyperammonemia (HP:0001987)4.55847931
13Epidermoid cyst (HP:0200040)4.54433137
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.54363358
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.42468089
16Abnormality of the common coagulation pathway (HP:0010990)4.42082749
17Fat malabsorption (HP:0002630)4.29446863
18Hyperglycinemia (HP:0002154)4.26964109
19Hypoalphalipoproteinemia (HP:0003233)4.25648817
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.23974905
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14736488
22Ketosis (HP:0001946)4.14718796
23Abnormality of methionine metabolism (HP:0010901)4.11098980
24Widely patent fontanelles and sutures (HP:0004492)4.03953343
25Hyperglycinuria (HP:0003108)3.97854281
26Conjugated hyperbilirubinemia (HP:0002908)3.96679539
27Abnormality of serine family amino acid metabolism (HP:0010894)3.91151047
28Abnormality of glycine metabolism (HP:0010895)3.91151047
29Hypoglycemic coma (HP:0001325)3.84925497
30Abnormality of complement system (HP:0005339)3.82047298
31Abnormality of pyrimidine metabolism (HP:0004353)3.78386184
32Hypercholesterolemia (HP:0003124)3.71537250
33Abnormality of the intrinsic pathway (HP:0010989)3.70296872
34Abnormality of the vitamin B12 metabolism (HP:0004341)3.62728477
35Confusion (HP:0001289)3.54104353
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39394996
37Abnormality of vitamin B metabolism (HP:0004340)3.39034651
38Hyperbilirubinemia (HP:0002904)3.35203440
39Ileus (HP:0002595)3.34036827
40Abnormality of fatty-acid metabolism (HP:0004359)3.31069683
41Chronic diarrhea (HP:0002028)3.30187357
42Facial shape deformation (HP:0011334)3.19989448
43Potter facies (HP:0002009)3.19989448
44Nephritis (HP:0000123)3.12197041
45Abnormality of nucleobase metabolism (HP:0010932)3.08693464
46Steatorrhea (HP:0002570)3.06724479
47Nausea (HP:0002018)3.05415406
48Spontaneous abortion (HP:0005268)3.03212242
49Acanthocytosis (HP:0001927)3.01644257
50Delayed CNS myelination (HP:0002188)2.95961515
51Proximal tubulopathy (HP:0000114)2.95324852
52Ketoacidosis (HP:0001993)2.93178147
53Wide cranial sutures (HP:0010537)2.92719133
54Abnormality of serum amino acid levels (HP:0003112)2.92718621
55Hepatocellular carcinoma (HP:0001402)2.92003907
56Myocardial infarction (HP:0001658)2.88911542
57Hypochromic microcytic anemia (HP:0004840)2.88645371
58Nephrolithiasis (HP:0000787)2.85005319
59Metabolic acidosis (HP:0001942)2.82346910
60Skin nodule (HP:0200036)2.78511079
61Pigmentary retinal degeneration (HP:0001146)2.77959444
62Systemic lupus erythematosus (HP:0002725)2.77538680
63Abnormality of purine metabolism (HP:0004352)2.73847104
64Increased purine levels (HP:0004368)2.73306763
65Hyperuricemia (HP:0002149)2.73306763
66Hypophosphatemia (HP:0002148)2.70511880
67Malnutrition (HP:0004395)2.62055767
68Megaloblastic anemia (HP:0001889)2.61195033
69Hyperphosphaturia (HP:0003109)2.55990520
70Lethargy (HP:0001254)2.53532768
71Vascular calcification (HP:0004934)2.53366936
72Abnormal urine phosphate concentration (HP:0012599)2.52733448
73Dicarboxylic aciduria (HP:0003215)2.52421667
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52421667
75Hypoglycemic seizures (HP:0002173)2.49622449
76Abnormal gallbladder morphology (HP:0012437)2.47510443
77Abnormal gallbladder physiology (HP:0012438)2.44687591
78Cholecystitis (HP:0001082)2.44687591
79Cholelithiasis (HP:0001081)2.43342213
80Alkalosis (HP:0001948)2.41345404
81Spastic diplegia (HP:0001264)2.40162906
82Amyloidosis (HP:0011034)2.39162190
83Thin bony cortex (HP:0002753)2.37109813
84Gout (HP:0001997)2.36768367
85Abdominal distention (HP:0003270)2.36119956
86Glomerulonephritis (HP:0000099)2.34718753
87Irritability (HP:0000737)2.31832807
88Poikilocytosis (HP:0004447)2.30061645
89Mitral stenosis (HP:0001718)2.28618103
90Cerebral edema (HP:0002181)2.28191607
91Recurrent gram-negative bacterial infections (HP:0005420)2.28152260
92Cardiovascular calcification (HP:0011915)2.24302859
93Cerebral palsy (HP:0100021)2.23990076
94Neonatal onset (HP:0003623)2.23848689
95Gingival bleeding (HP:0000225)2.19844477
96Pancreatitis (HP:0001733)2.19218058
97Sensorimotor neuropathy (HP:0007141)2.18947269
98Esophageal varix (HP:0002040)2.17014726
99Late onset (HP:0003584)2.14501091
100Hydroxyprolinuria (HP:0003080)2.13978000
101Abnormality of proline metabolism (HP:0010907)2.13978000
102Focal segmental glomerulosclerosis (HP:0000097)2.13292407
103Hypotension (HP:0002615)2.12406386
104Abnormality of alkaline phosphatase activity (HP:0004379)2.11719416
105Brushfield spots (HP:0001088)2.10809681
106Menorrhagia (HP:0000132)2.08967550
107Enlarged kidneys (HP:0000105)2.05054049
108Vomiting (HP:0002013)2.04139491
109Thrombophlebitis (HP:0004418)2.02703572
110Hyperinsulinemic hypoglycemia (HP:0000825)2.02323534
111Hemorrhage of the eye (HP:0011885)2.01061202
112Abnormality of the gallbladder (HP:0005264)2.00928302
113Opisthotonus (HP:0002179)1.99884447
114Generalized aminoaciduria (HP:0002909)1.99569865
115Elevated alkaline phosphatase (HP:0003155)1.96555908
116Rickets (HP:0002748)1.93806917
117Abnormality of transition element cation homeostasis (HP:0011030)1.92144631
118Protuberant abdomen (HP:0001538)1.91334980
119Osteomalacia (HP:0002749)1.90863277
120Abnormality of iron homeostasis (HP:0011031)1.90511034
121Reticulocytosis (HP:0001923)1.86019963
122Abnormality of vitamin metabolism (HP:0100508)1.85931713
123Abnormal cartilage morphology (HP:0002763)1.85851280
124Congenital sensorineural hearing impairment (HP:0008527)1.81652818
125Renal cortical cysts (HP:0000803)1.81369799
126Hypophosphatemic rickets (HP:0004912)1.81071951
127Elevated hepatic transaminases (HP:0002910)1.80446676
128Glycosuria (HP:0003076)1.78699691
129Abnormality of urine glucose concentration (HP:0011016)1.78699691
130Purpura (HP:0000979)1.77652002
131Abnormal enzyme/coenzyme activity (HP:0012379)1.77217925
132Hyperglycemia (HP:0003074)1.73643924
133Renal tubular acidosis (HP:0001947)1.71378655
134Glomerulosclerosis (HP:0000096)1.71160674
135Delayed epiphyseal ossification (HP:0002663)1.70893096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.75839779
2ACVR1B6.51708996
3ERN14.73329583
4FGFR44.48819495
5SIK14.27514981
6TAOK33.15989518
7ERBB42.89837733
8INSRR2.89570339
9MST1R2.59792223
10MAP2K42.22404636
11FRK2.17607088
12PKN22.09259147
13TESK21.97413458
14PDK21.97160333
15MAPK111.93378203
16FLT31.77428409
17PIK3CG1.73265353
18LATS11.71804853
19PTK61.70798549
20TYK21.69274790
21TRIB31.64499808
22PRPF4B1.63189196
23GRK61.58420576
24ABL21.39636287
25MAP4K11.39245196
26MAP3K101.38150571
27DAPK21.33882298
28NEK91.33754625
29DDR21.27810023
30MAP3K71.27256328
31KDR1.23319835
32FGFR21.22157207
33PRKAA21.19600545
34JAK21.17836697
35MAP3K121.15655406
36TBK11.13925702
37ERBB21.09095840
38MATK1.04666303
39MAP2K31.04264174
40MET1.01536817
41PINK10.97808056
42JAK10.96471810
43EPHB10.96195206
44MAPK40.95799757
45MAP3K30.94272156
46MAP3K140.94078433
47MAP3K110.92120144
48MYLK0.90610408
49RIPK10.89953590
50PRKCZ0.88995361
51STK390.88617112
52CDC42BPA0.88239396
53MAPK150.85250125
54NLK0.84159994
55RIPK40.81992351
56CDK60.81059751
57MAP2K60.80877064
58STK38L0.80139062
59TNIK0.80081088
60DYRK1B0.76463840
61PRKACG0.75231797
62EPHA30.74961025
63TESK10.73639362
64PDGFRA0.72605947
65IRAK30.71983961
66MAPK120.71363886
67CSK0.71211128
68CAMK2G0.69769525
69PRKAA10.68045249
70OXSR10.67268062
71SMG10.66660248
72GSK3A0.66365580
73PTK20.65864434
74TIE10.65635567
75TAOK10.62446732
76CAMK1D0.59205409
77SGK30.58498520
78KSR20.58472623
79PDPK10.58123764
80AKT30.56373264
81SRC0.53213854
82FGFR30.53168258
83IKBKE0.52996609
84FER0.52687578
85PRKCQ0.51570213
86MAP2K20.51507771
87MAPK70.50743197
88TAOK20.49873413
89ICK0.49338332
90GRK10.48375451
91CSF1R0.47376056
92ZAP700.46958465
93MAP2K10.46927144
94EPHA20.46388602
95STK240.46025242
96TGFBR20.45523685
97MAP3K50.45443371
98PBK0.43511818
99LMTK20.41746818
100MAP3K10.41461569
101PRKG20.40618067
102CSNK1G10.40357529
103IGF1R0.40006735
104CDK40.39991039
105MAP3K20.38149368
106IRAK10.36658434
107RET0.36532400
108MAP3K130.36446377
109FYN0.36311111
110PIM10.35152492
111EPHA40.35146569
112MTOR0.34474099
113PDK10.34231894
114MST40.33843487
115SGK20.33562480
116BMX0.33407362
117NUAK10.32641382
118MAP3K60.31845181
119EGFR0.31098401
120CAMK2D0.30855829
121PRKACA0.30315626
122PKN10.29328594
123PRKCG0.29080508
124PRKCA0.27916800
125CAMK40.27540082
126PRKCD0.27284666
127EPHB20.25009632
128PRKG10.24568905
129PAK40.24523046
130ITK0.22592704
131PAK30.22456234
132PIK3CA0.21938380
133MAP3K80.21923573
134MELK0.21037205
135CAMK2B0.20982311
136LATS20.19923620
137STK30.19862839
138SGK2230.19383659
139PRKCB0.18890002
140SYK0.18558213
141LCK0.17349071

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.42739045
2Nitrogen metabolism_Homo sapiens_hsa009103.48406348
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32565680
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23299605
5Arginine biosynthesis_Homo sapiens_hsa002203.04902846
6Tryptophan metabolism_Homo sapiens_hsa003802.69871078
7Complement and coagulation cascades_Homo sapiens_hsa046102.68818622
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64885028
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57118835
10Fatty acid degradation_Homo sapiens_hsa000712.50463274
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47167777
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31410873
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22358264
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13062790
15Butanoate metabolism_Homo sapiens_hsa006502.09847279
16Peroxisome_Homo sapiens_hsa041462.05766445
17Histidine metabolism_Homo sapiens_hsa003401.97210279
18PPAR signaling pathway_Homo sapiens_hsa033201.93487676
19Chemical carcinogenesis_Homo sapiens_hsa052041.91484081
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89795953
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.87551416
22Caffeine metabolism_Homo sapiens_hsa002321.87537902
23Propanoate metabolism_Homo sapiens_hsa006401.83624325
24Fatty acid metabolism_Homo sapiens_hsa012121.78999994
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75687765
26beta-Alanine metabolism_Homo sapiens_hsa004101.69747708
27Retinol metabolism_Homo sapiens_hsa008301.69243385
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69118524
29Staphylococcus aureus infection_Homo sapiens_hsa051501.67538416
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66854398
31Fat digestion and absorption_Homo sapiens_hsa049751.60981164
32Bile secretion_Homo sapiens_hsa049761.57772465
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54908637
34Selenocompound metabolism_Homo sapiens_hsa004501.54627124
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52992136
36Phenylalanine metabolism_Homo sapiens_hsa003601.50792996
37Starch and sucrose metabolism_Homo sapiens_hsa005001.42033440
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41706274
39Tyrosine metabolism_Homo sapiens_hsa003501.39627055
40Sulfur metabolism_Homo sapiens_hsa009201.38633852
41Pyruvate metabolism_Homo sapiens_hsa006201.36017085
42Folate biosynthesis_Homo sapiens_hsa007901.35818160
43Fatty acid elongation_Homo sapiens_hsa000621.31291385
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.25994688
45ABC transporters_Homo sapiens_hsa020101.23653529
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18378840
47Vitamin digestion and absorption_Homo sapiens_hsa049771.16485526
48Steroid biosynthesis_Homo sapiens_hsa001001.14596787
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.12939207
50Carbon metabolism_Homo sapiens_hsa012001.12623844
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.05266678
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02176621
53Arginine and proline metabolism_Homo sapiens_hsa003301.00124121
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96038702
55Vitamin B6 metabolism_Homo sapiens_hsa007500.94769705
56Sulfur relay system_Homo sapiens_hsa041220.92714540
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92661995
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91820496
59Lysine degradation_Homo sapiens_hsa003100.81178201
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77770385
61Glycerolipid metabolism_Homo sapiens_hsa005610.75242365
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73579780
63Glutathione metabolism_Homo sapiens_hsa004800.71989829
64One carbon pool by folate_Homo sapiens_hsa006700.68709963
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64236158
66Pentose phosphate pathway_Homo sapiens_hsa000300.59556378
67Other glycan degradation_Homo sapiens_hsa005110.56758063
68Fatty acid biosynthesis_Homo sapiens_hsa000610.54487820
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50028989
70Galactose metabolism_Homo sapiens_hsa000520.47080300
71Metabolic pathways_Homo sapiens_hsa011000.46573450
72Sphingolipid metabolism_Homo sapiens_hsa006000.40021769
73Fructose and mannose metabolism_Homo sapiens_hsa000510.36023318
74Prion diseases_Homo sapiens_hsa050200.34319417
75Pertussis_Homo sapiens_hsa051330.33961151
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32213953
77Asthma_Homo sapiens_hsa053100.31465375
78Linoleic acid metabolism_Homo sapiens_hsa005910.26418494
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.21978564
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.21212945
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.20835124
82* Insulin resistance_Homo sapiens_hsa049310.16689301
83Allograft rejection_Homo sapiens_hsa053300.15472566
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14184400
85Renin-angiotensin system_Homo sapiens_hsa046140.14117979
86Pancreatic secretion_Homo sapiens_hsa049720.13078265
87Autoimmune thyroid disease_Homo sapiens_hsa053200.12835210
88Graft-versus-host disease_Homo sapiens_hsa053320.09236389
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01695200
90* Glucagon signaling pathway_Homo sapiens_hsa049220.00750122
91Renin secretion_Homo sapiens_hsa049240.00251055
92Amoebiasis_Homo sapiens_hsa05146-0.2328412
93Bladder cancer_Homo sapiens_hsa05219-0.2111109
94Ether lipid metabolism_Homo sapiens_hsa00565-0.2093663
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2042494
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1865737
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1694352
98Regulation of autophagy_Homo sapiens_hsa04140-0.1644730
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1580394
100Protein digestion and absorption_Homo sapiens_hsa04974-0.1543894
101Hepatitis C_Homo sapiens_hsa05160-0.1471593
102Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1371615
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1255958
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1090096
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1065125
106African trypanosomiasis_Homo sapiens_hsa05143-0.1023409
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0729392
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0546192
109* AMPK signaling pathway_Homo sapiens_hsa04152-0.0479626
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0477783
111Mineral absorption_Homo sapiens_hsa04978-0.0349641
112Serotonergic synapse_Homo sapiens_hsa04726-0.0309057
113Type I diabetes mellitus_Homo sapiens_hsa04940-0.0160892
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0129700
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0084944

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »