CREB3L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.91755365
2Golgi transport vesicle coating (GO:0048200)5.91755365
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.69948324
4COPII vesicle coating (GO:0048208)4.28683298
5protein retention in ER lumen (GO:0006621)4.20479171
6exocrine pancreas development (GO:0031017)4.18288696
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.73872158
8collagen fibril organization (GO:0030199)3.55985208
9cell adhesion mediated by integrin (GO:0033627)3.55012568
10positive regulation of nuclease activity (GO:0032075)3.50054719
11type B pancreatic cell development (GO:0003323)3.47903734
12chondrocyte development (GO:0002063)3.38160430
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.36447318
14desmosome organization (GO:0002934)3.30316096
15sequestering of extracellular ligand from receptor (GO:0035581)3.28898834
16regulation of extracellular matrix disassembly (GO:0010715)3.27418808
17cellular response to vitamin D (GO:0071305)3.26427459
18vascular endothelial growth factor signaling pathway (GO:0038084)3.26204868
19positive regulation of hormone biosynthetic process (GO:0046886)3.20277442
20endoplasmic reticulum unfolded protein response (GO:0030968)3.19923516
21basement membrane organization (GO:0071711)3.17740427
22glandular epithelial cell development (GO:0002068)3.15437074
23retina vasculature morphogenesis in camera-type eye (GO:0061299)3.14273480
24regulation of transforming growth factor beta1 production (GO:0032908)3.13277459
25regulation of nuclease activity (GO:0032069)3.10705694
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.09980608
27cellular response to unfolded protein (GO:0034620)3.08731234
28regulation of cholesterol homeostasis (GO:2000188)3.08665692
29glomerular basement membrane development (GO:0032836)3.07212316
30keratan sulfate catabolic process (GO:0042340)3.04946738
31cell-substrate junction assembly (GO:0007044)3.04882632
32vesicle coating (GO:0006901)3.02189646
33cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.01238491
34endothelial cell morphogenesis (GO:0001886)2.99436724
35positive regulation of extracellular matrix organization (GO:1903055)2.96792987
36ER-nucleus signaling pathway (GO:0006984)2.94957978
37lymph vessel development (GO:0001945)2.94398974
38protein heterotrimerization (GO:0070208)2.93248356
39endocrine pancreas development (GO:0031018)2.92671634
40hypotonic response (GO:0006971)2.89760515
41regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.88737387
42pericardium development (GO:0060039)2.87160858
43cellular response to vitamin (GO:0071295)2.86763194
44cellular response to topologically incorrect protein (GO:0035967)2.85411912
45regulation of apoptotic process involved in morphogenesis (GO:1902337)2.82998620
46peptide hormone processing (GO:0016486)2.82572832
47protein maturation by protein folding (GO:0022417)2.81125058
48regulation of cardioblast differentiation (GO:0051890)2.79201309
49toxin metabolic process (GO:0009404)2.79078272
50protein hydroxylation (GO:0018126)2.78617123
51atrioventricular valve morphogenesis (GO:0003181)2.76568925
52endocardial cushion development (GO:0003197)2.75542290
53protein carboxylation (GO:0018214)2.75184637
54peptidyl-glutamic acid carboxylation (GO:0017187)2.75184637
55venous blood vessel morphogenesis (GO:0048845)2.72320483
56apoptotic cell clearance (GO:0043277)2.70925381
57substrate-dependent cell migration (GO:0006929)2.69728934
58positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69605568
59renal filtration (GO:0097205)2.69567176
60regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68752630
61regulation of plasminogen activation (GO:0010755)2.65192046
62columnar/cuboidal epithelial cell development (GO:0002066)2.64181260
63stress fiber assembly (GO:0043149)2.64134255
64positive regulation of glycogen biosynthetic process (GO:0045725)2.61876205
65signal peptide processing (GO:0006465)2.61856632
66cell migration involved in heart development (GO:0060973)2.61658965
67chondrocyte proliferation (GO:0035988)2.61136777
68positive regulation of endothelial cell apoptotic process (GO:2000353)2.60732911
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60105230
70pinocytosis (GO:0006907)2.59287368
71transcytosis (GO:0045056)2.58529222
72collagen metabolic process (GO:0032963)2.57999829
73focal adhesion assembly (GO:0048041)2.57639583
74cell-substrate adherens junction assembly (GO:0007045)2.57639583
754-hydroxyproline metabolic process (GO:0019471)2.57359036
76endocardial cushion morphogenesis (GO:0003203)2.56697657
77adherens junction assembly (GO:0034333)2.56532554
78lung vasculature development (GO:0060426)2.56218813
79positive regulation of p38MAPK cascade (GO:1900745)2.54313034
80blood vessel maturation (GO:0001955)2.54289147
81bundle of His cell to Purkinje myocyte communication (GO:0086069)2.54281529
82cell migration involved in sprouting angiogenesis (GO:0002042)2.54180822
83blood vessel endothelial cell migration (GO:0043534)2.54176821
84embryonic process involved in female pregnancy (GO:0060136)2.54095090
85negative regulation of osteoblast proliferation (GO:0033689)2.53543474
86glomerular filtration (GO:0003094)2.53421461
87positive regulation of osteoblast proliferation (GO:0033690)2.52938050
88mesenchyme morphogenesis (GO:0072132)2.52601256
89regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.52552450
90skin morphogenesis (GO:0043589)2.52546373
91epithelial cell-cell adhesion (GO:0090136)2.51755893
92multicellular organismal macromolecule metabolic process (GO:0044259)2.51743007
93collagen catabolic process (GO:0030574)2.51499183
94regulation of transforming growth factor beta2 production (GO:0032909)2.51406367
95multicellular organismal catabolic process (GO:0044243)2.51249177
96gland morphogenesis (GO:0022612)2.50886026
97sequestering of metal ion (GO:0051238)2.49969801
98lymphangiogenesis (GO:0001946)2.49886743
99multicellular organismal metabolic process (GO:0044236)2.48225807
100* response to endoplasmic reticulum stress (GO:0034976)2.47845897
101wound healing, spreading of epidermal cells (GO:0035313)2.47679047
102regulation of osteoblast proliferation (GO:0033688)2.47308587
103endodermal cell differentiation (GO:0035987)2.47013952
104regulation of early endosome to late endosome transport (GO:2000641)2.46907586
105regulation of type B pancreatic cell apoptotic process (GO:2000674)2.46673940
106hyaluronan catabolic process (GO:0030214)2.46459853
107polarized epithelial cell differentiation (GO:0030859)2.46402217
108negative regulation of cartilage development (GO:0061037)2.46254870
109substrate adhesion-dependent cell spreading (GO:0034446)2.46015678
110protein localization to endosome (GO:0036010)2.45320925
111regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.43009848
112adhesion of symbiont to host (GO:0044406)2.42666648
113bone trabecula formation (GO:0060346)2.42580485
114positive regulation of cartilage development (GO:0061036)2.42410182
115negative regulation of fibrinolysis (GO:0051918)2.42246881
116extracellular matrix disassembly (GO:0022617)2.41689504
117negative regulation of fatty acid transport (GO:2000192)2.41214328
118anterior/posterior axis specification, embryo (GO:0008595)2.39935257
119negative regulation of glycogen biosynthetic process (GO:0045719)2.39518619
120peptidyl-proline hydroxylation (GO:0019511)2.39069098
121endocrine hormone secretion (GO:0060986)2.38551182
122ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.38424733
123protein N-linked glycosylation via asparagine (GO:0018279)2.38018900
124smooth muscle tissue development (GO:0048745)2.38016521
125coronary vasculature morphogenesis (GO:0060977)2.37931453
126dorsal/ventral axis specification (GO:0009950)2.37135448
127peptidyl-asparagine modification (GO:0018196)2.36584728
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.36193041
129regulation of steroid hormone biosynthetic process (GO:0090030)2.35633375
130* response to unfolded protein (GO:0006986)2.35467408
131UDP-N-acetylglucosamine metabolic process (GO:0006047)2.35433931
132mesenchymal-epithelial cell signaling (GO:0060638)2.35081951
133somite development (GO:0061053)2.34369071
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34338373
135cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.34184135
136nucleotide-sugar biosynthetic process (GO:0009226)2.33958819
137mesenchymal cell differentiation (GO:0048762)2.33718575
138regulation of cardioblast proliferation (GO:0003264)2.33299758
139regulation of secondary heart field cardioblast proliferation (GO:0003266)2.33299758
140negative regulation of smooth muscle cell migration (GO:0014912)2.32977483
141glandular epithelial cell differentiation (GO:0002067)2.32318074
142ER overload response (GO:0006983)2.31567569
143regulation of cartilage development (GO:0061035)2.29015097
144negative regulation of chondrocyte differentiation (GO:0032331)2.28878219
145embryonic retina morphogenesis in camera-type eye (GO:0060059)2.27506503
146hemidesmosome assembly (GO:0031581)2.26903108
147hippo signaling (GO:0035329)2.26761945
148positive regulation of mesenchymal cell proliferation (GO:0002053)2.24091376
149mesodermal cell differentiation (GO:0048333)2.23773312
150glomerular visceral epithelial cell development (GO:0072015)2.22331847
151epithelial cell fate commitment (GO:0072148)2.21533530
152* response to topologically incorrect protein (GO:0035966)2.20910834
153trabecula formation (GO:0060343)2.19827889
154regulation of p38MAPK cascade (GO:1900744)2.19550125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.73210759
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.62336343
3CLOCK_20551151_ChIP-Seq_293T_Human2.77199982
4ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.64732860
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.62125125
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61780230
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.60994116
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57669582
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56279319
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.44976211
11* EP300_21415370_ChIP-Seq_HL-1_Mouse2.26692745
12* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13019810
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.10776071
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.07601438
15* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.97709713
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92132084
17LXR_22158963_ChIP-Seq_LIVER_Mouse1.91153873
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.90463599
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88565142
20GATA1_22025678_ChIP-Seq_K562_Human1.86380365
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79083531
22CJUN_26792858_Chip-Seq_BT549_Human1.78641145
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77686745
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77598834
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76749093
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75779626
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75775376
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.75118900
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.75118900
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68822514
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.67865815
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65549125
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62886783
34AR_21909140_ChIP-Seq_LNCAP_Human1.61908580
35SOX2_20726797_ChIP-Seq_SW620_Human1.61194923
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.57883375
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.57774041
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56554612
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55855687
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55586995
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54951490
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.53094083
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52486021
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50632693
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50586076
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50586076
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50490570
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49631345
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49016047
50* ISL1_27105846_Chip-Seq_CPCs_Mouse1.47264850
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46023893
52BRD4_25478319_ChIP-Seq_HGPS_Human1.45651235
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45263895
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44186859
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.41197449
56* FOXA2_19822575_ChIP-Seq_HepG2_Human1.37917869
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37730434
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36380212
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34801451
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31954552
61TP53_16413492_ChIP-PET_HCT116_Human1.31093170
62ZNF263_19887448_ChIP-Seq_K562_Human1.30544169
63* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28091231
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26960276
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26859799
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24788283
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24712789
68* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23143322
69* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23029823
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22114387
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19651900
72AHR_22903824_ChIP-Seq_MCF-7_Human1.19075449
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17960924
74EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17151655
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15697376
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14973110
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.14738743
78GATA6_25053715_ChIP-Seq_YYC3_Human1.14419246
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14302281
80FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14007153
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12851387
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.11133144
83* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10794815
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10741602
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10586001
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09468826
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08164600
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08074734
89ATF3_27146783_Chip-Seq_COLON_Human1.07786078
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.06748458
91TP53_22127205_ChIP-Seq_IMR90_Human1.06355639
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04710920
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04426267
94GATA4_25053715_ChIP-Seq_YYC3_Human1.03022475
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.01581391
96GATA3_24758297_ChIP-Seq_MCF-7_Human1.01016130
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00170374
98RACK7_27058665_Chip-Seq_MCF-7_Human1.00084231
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00019495
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00019495
101* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99419876
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.98603218
103* HNF4A_19822575_ChIP-Seq_HepG2_Human0.97943265
104TP63_23658742_ChIP-Seq_EP156T_Human0.97409506
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96070767
106TP53_18474530_ChIP-ChIP_U2OS_Human0.95305398
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.95081837
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94739703
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94677763
110KDM2B_26808549_Chip-Seq_K562_Human0.93994803
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93667783
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93241846
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92158832
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90343963
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89917426
116* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89699823
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89147165
118RUNX1_27514584_Chip-Seq_MCF-7_Human0.88266236
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88068066
120* GATA1_19941826_ChIP-Seq_K562_Human0.87144585
121EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86983213
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86983213
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86770170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.10299194
2MP0004272_abnormal_basement_membrane3.56227903
3MP0005503_abnormal_tendon_morphology3.46786029
4MP0006054_spinal_hemorrhage3.12727911
5MP0010368_abnormal_lymphatic_system2.87841591
6MP0002877_abnormal_melanocyte_morpholog2.73842927
7MP0010352_gastrointestinal_tract_polyps2.54699885
8MP0005275_abnormal_skin_tensile2.50121609
9MP0001879_abnormal_lymphatic_vessel2.47444560
10MP0000013_abnormal_adipose_tissue2.41654256
11MP0003950_abnormal_plasma_membrane2.41590987
12MP0003283_abnormal_digestive_organ2.39594153
13MP0009780_abnormal_chondrocyte_physiolo2.39420074
14MP0003705_abnormal_hypodermis_morpholog2.18035357
15MP0005409_darkened_coat_color2.13145516
16MP0003279_aneurysm2.04243911
17MP0009384_cardiac_valve_regurgitation2.00426083
18MP0002896_abnormal_bone_mineralization1.92308727
19MP0003941_abnormal_skin_development1.88011612
20MP0005623_abnormal_meninges_morphology1.87980986
21MP0000003_abnormal_adipose_tissue1.79498561
22MP0003122_maternal_imprinting1.79434285
23MP0004264_abnormal_extraembryonic_tissu1.73159017
24MP0003300_gastrointestinal_ulcer1.70640401
25MP0003566_abnormal_cell_adhesion1.70134607
26MP0005508_abnormal_skeleton_morphology1.68001938
27MP0005220_abnormal_exocrine_pancreas1.60688253
28MP0001958_emphysema1.59813139
29MP0003252_abnormal_bile_duct1.56415616
30MP0004084_abnormal_cardiac_muscle1.56204317
31MP0009250_abnormal_appendicular_skeleto1.53908156
32MP0001944_abnormal_pancreas_morphology1.53125647
33MP0009840_abnormal_foam_cell1.52040451
34MP0000678_abnormal_parathyroid_gland1.52011798
35MP0002295_abnormal_pulmonary_circulatio1.48592332
36MP0003045_fibrosis1.45926464
37MP0002837_dystrophic_cardiac_calcinosis1.44196983
38MP0003195_calcinosis1.43006603
39MP0002108_abnormal_muscle_morphology1.42582471
40* MP0000163_abnormal_cartilage_morphology1.40800292
41MP0004043_abnormal_pH_regulation1.38153391
42MP0003868_abnormal_feces_composition1.36916183
43MP0000462_abnormal_digestive_system1.32880036
44MP0005248_abnormal_Harderian_gland1.32740709
45MP0003385_abnormal_body_wall1.31637619
46MP0000767_abnormal_smooth_muscle1.30120119
47MP0005257_abnormal_intraocular_pressure1.27983684
48MP0002909_abnormal_adrenal_gland1.26765761
49MP0005367_renal/urinary_system_phenotyp1.24139013
50MP0000516_abnormal_urinary_system1.24139013
51MP0001299_abnormal_eye_distance/1.23212050
52MP0003942_abnormal_urinary_system1.21669963
53MP0000537_abnormal_urethra_morphology1.21113402
54MP0001915_intracranial_hemorrhage1.18298984
55MP0000534_abnormal_ureter_morphology1.15403441
56* MP0002115_abnormal_skeleton_extremities1.14103075
57MP0009053_abnormal_anal_canal1.12496709
58MP0002693_abnormal_pancreas_physiology1.12334501
59MP0005164_abnormal_response_to1.11767962
60MP0002060_abnormal_skin_morphology1.10926100
61MP0005360_urolithiasis1.10775173
62MP0002168_other_aberrant_phenotype1.10671815
63MP0005408_hypopigmentation1.10647347
64MP0005058_abnormal_lysosome_morphology1.10528811
65MP0000428_abnormal_craniofacial_morphol1.08506337
66MP0005375_adipose_tissue_phenotype1.07906746
67MP0006138_congestive_heart_failure1.05595726
68MP0004036_abnormal_muscle_relaxation1.05359391
69MP0003935_abnormal_craniofacial_develop1.04913014
70MP0005187_abnormal_penis_morphology1.03179236
71MP0003828_pulmonary_edema1.02826625
72MP0003191_abnormal_cellular_cholesterol1.02775228
73MP0002933_joint_inflammation1.00721950
74MP0005023_abnormal_wound_healing0.98252198
75MP0004233_abnormal_muscle_weight0.96650601
76MP0000613_abnormal_salivary_gland0.96279273
77MP0002932_abnormal_joint_morphology0.95823993
78MP0003172_abnormal_lysosome_physiology0.95442242
79MP0003091_abnormal_cell_migration0.95379436
80MP0002234_abnormal_pharynx_morphology0.95067795
81MP0002928_abnormal_bile_duct0.94327385
82* MP0001270_distended_abdomen0.94326077
83MP0002089_abnormal_postnatal_growth/wei0.94004932
84MP0003567_abnormal_fetal_cardiomyocyte0.93892094
85MP0000733_abnormal_muscle_development0.93736131
86MP0003115_abnormal_respiratory_system0.92831408
87MP0002998_abnormal_bone_remodeling0.91598449
88MP0002925_abnormal_cardiovascular_devel0.91349065
89MP0002876_abnormal_thyroid_physiology0.90794208
90MP0002128_abnormal_blood_circulation0.90487419
91MP0008775_abnormal_heart_ventricle0.89488386
92MP0010030_abnormal_orbit_morphology0.88590300
93MP0010630_abnormal_cardiac_muscle0.87573803
94* MP0002113_abnormal_skeleton_development0.87231786
95MP0002139_abnormal_hepatobiliary_system0.86893449
96MP0005390_skeleton_phenotype0.84065780
97MP0009643_abnormal_urine_homeostasis0.83734628
98MP0005365_abnormal_bile_salt0.82973981
99MP0004808_abnormal_hematopoietic_stem0.82038337
100MP0010329_abnormal_lipoprotein_level0.81985366
101MP0003937_abnormal_limbs/digits/tail_de0.80708091
102MP0010234_abnormal_vibrissa_follicle0.80361439
103MP0002086_abnormal_extraembryonic_tissu0.80082834
104MP0001542_abnormal_bone_strength0.79730013
105MP0003755_abnormal_palate_morphology0.79697869
106MP0002166_altered_tumor_susceptibility0.79419552
107MP0004145_abnormal_muscle_electrophysio0.79312596
108MP0003795_abnormal_bone_structure0.79263977
109MP0001348_abnormal_lacrimal_gland0.78701440
110MP0003453_abnormal_keratinocyte_physiol0.78542743
111MP0005621_abnormal_cell_physiology0.78259173
112MP0000432_abnormal_head_morphology0.77693029
113MP0005076_abnormal_cell_differentiation0.77435824
114MP0002282_abnormal_trachea_morphology0.77402478
115MP0001243_abnormal_dermal_layer0.76796021
116MP0005670_abnormal_white_adipose0.76615556
117MP0010386_abnormal_urinary_bladder0.76145590
118* MP0002109_abnormal_limb_morphology0.76030952
119MP0003119_abnormal_digestive_system0.75398972
120MP0001614_abnormal_blood_vessel0.75368053
121MP0001666_abnormal_nutrient_absorption0.75332033
122MP0005330_cardiomyopathy0.74851402
123MP0001661_extended_life_span0.74199958
124MP0000566_synostosis0.73892417
125MP0000266_abnormal_heart_morphology0.73627476
126MP0001849_ear_inflammation0.73558399
127* MP0002116_abnormal_craniofacial_bone0.73144764
128MP0000049_abnormal_middle_ear0.73032242
129MP0005197_abnormal_uvea_morphology0.72920654
130* MP0004134_abnormal_chest_morphology0.72907517
131MP0001175_abnormal_lung_morphology0.70425928
132MP0004858_abnormal_nervous_system0.69263701
133MP0005595_abnormal_vascular_smooth0.69167791
134MP0005451_abnormal_body_composition0.68925909
135MP0000681_abnormal_thyroid_gland0.68307606
136MP0003984_embryonic_growth_retardation0.65467926
137MP0005171_absent_coat_pigmentation0.64969743
138MP0000627_abnormal_mammary_gland0.63296308
139MP0005165_increased_susceptibility_to0.61998155
140MP0002396_abnormal_hematopoietic_system0.61207928
141MP0002088_abnormal_embryonic_growth/wei0.60486245
142MP0004883_abnormal_blood_vessel0.59238782

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.27298510
2Protrusio acetabuli (HP:0003179)4.22900363
3Epiphyseal dysplasia (HP:0002656)3.77747295
4Hypoplastic ischia (HP:0003175)3.68904296
5Hyperinsulinemic hypoglycemia (HP:0000825)3.55772043
6Broad metatarsal (HP:0001783)3.40664170
7Abnormality of the ischium (HP:0003174)3.37400286
8Cervical subluxation (HP:0003308)3.20404476
9Hypoglycemic seizures (HP:0002173)3.19861687
10Cerebral aneurysm (HP:0004944)3.16605605
11Hypoglycemic coma (HP:0001325)3.10408522
12Aortic aneurysm (HP:0004942)3.02714933
13Aortic dissection (HP:0002647)2.97825602
14Shallow orbits (HP:0000586)2.94002892
15Atrophic scars (HP:0001075)2.84502410
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.74776927
17Vertebral compression fractures (HP:0002953)2.73970090
18Symptomatic seizures (HP:0011145)2.70588025
19Cardiovascular calcification (HP:0011915)2.62715895
20Ankle contracture (HP:0006466)2.62248270
21Hyperglycemia (HP:0003074)2.61852079
22Aneurysm (HP:0002617)2.59184476
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.54735882
24Osteolytic defects of the hand bones (HP:0009699)2.54735882
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.53975711
26Mitral stenosis (HP:0001718)2.50733070
27Thin bony cortex (HP:0002753)2.48288809
28Pancreatic islet-cell hyperplasia (HP:0004510)2.46245838
29Genu recurvatum (HP:0002816)2.43493568
30Exostoses (HP:0100777)2.43400023
31Mildly elevated creatine phosphokinase (HP:0008180)2.38756306
32Cupped ribs (HP:0000887)2.38176294
33Vascular tortuosity (HP:0004948)2.36907133
34Peritonitis (HP:0002586)2.33435752
35Soft skin (HP:0000977)2.33169408
36Lymphangioma (HP:0100764)2.33009673
37Protuberant abdomen (HP:0001538)2.32260596
38Bladder diverticulum (HP:0000015)2.31575774
39Insulin-resistant diabetes mellitus (HP:0000831)2.30655984
40Spinal rigidity (HP:0003306)2.30170036
41Vitreoretinal degeneration (HP:0000655)2.29911052
42Thoracolumbar scoliosis (HP:0002944)2.27897935
43Abnormality of endocrine pancreas physiology (HP:0012093)2.26071005
44Abnormality of the pancreatic islet cells (HP:0006476)2.26071005
45Neonatal short-limb short stature (HP:0008921)2.24533393
46Flat acetabular roof (HP:0003180)2.22900228
47Platyspondyly (HP:0000926)2.22870226
48Blue sclerae (HP:0000592)2.22468039
49Osteoarthritis (HP:0002758)2.21573433
50Wormian bones (HP:0002645)2.20709277
51Right ventricular cardiomyopathy (HP:0011663)2.20329503
52Mitral valve prolapse (HP:0001634)2.19307793
53Abnormal pancreas size (HP:0012094)2.18758050
54Delayed epiphyseal ossification (HP:0002663)2.14508808
55Elbow flexion contracture (HP:0002987)2.14277819
56Syringomyelia (HP:0003396)2.13694409
57Spinal cord lesions (HP:0100561)2.13694409
58Abnormal ossification of hand bones (HP:0005921)2.11959983
59Fragile skin (HP:0001030)2.11910872
60Vascular calcification (HP:0004934)2.11825646
61Abnormal delivery (HP:0001787)2.09553420
62Large for gestational age (HP:0001520)2.09553097
63Mild short stature (HP:0003502)2.09138580
64Abnormal tarsal ossification (HP:0008369)2.08448961
65Arterial tortuosity (HP:0005116)2.07898715
66Natal tooth (HP:0000695)2.07147687
67Hepatoblastoma (HP:0002884)2.06437640
68Mucopolysacchariduria (HP:0008155)2.05823440
69Urinary glycosaminoglycan excretion (HP:0003541)2.05823440
70Follicular hyperkeratosis (HP:0007502)2.04870289
71Abdominal distention (HP:0003270)2.04294535
72Abnormal foot bone ossification (HP:0010675)2.04236723
73Abnormality of the intrinsic pathway (HP:0010989)2.04039721
74Ketoacidosis (HP:0001993)2.02572387
75Deep venous thrombosis (HP:0002625)2.02093425
76Hyperextensible skin (HP:0000974)2.01161138
77Abnormality of dentin (HP:0010299)2.00820438
78Abnormal vertebral ossification (HP:0100569)2.00633838
79Flared iliac wings (HP:0002869)2.00453519
80Mesomelia (HP:0003027)1.99224624
81Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.98454482
82Dilatation of the ascending aorta (HP:0005111)1.96197773
83Advanced eruption of teeth (HP:0006288)1.96034949
84Coxa vara (HP:0002812)1.96013074
85Long eyelashes (HP:0000527)1.95659765
86Bell-shaped thorax (HP:0001591)1.95035393
87Overgrowth (HP:0001548)1.94137668
88Delayed closure of the anterior fontanelle (HP:0001476)1.93418200
89Increased connective tissue (HP:0009025)1.93274782
90Ovoid vertebral bodies (HP:0003300)1.92762396
91Type 1 muscle fiber predominance (HP:0003803)1.91846126
92Nonimmune hydrops fetalis (HP:0001790)1.90033269
93Abnormality of the common coagulation pathway (HP:0010990)1.89399467
94Wide anterior fontanel (HP:0000260)1.87984564
95Hypokalemia (HP:0002900)1.87562016
96Camptodactyly of toe (HP:0001836)1.86648457
97Ectopia lentis (HP:0001083)1.86414571
98Biconcave vertebral bodies (HP:0004586)1.86179966
99Asymmetry of the thorax (HP:0001555)1.85931760
100Congenital glaucoma (HP:0001087)1.85571474
101Spondylolisthesis (HP:0003302)1.85292254
102Aortic regurgitation (HP:0001659)1.85102395
103Short nail (HP:0001799)1.83003439
104Joint laxity (HP:0001388)1.82913493
105Sparse lateral eyebrow (HP:0005338)1.82073956
106Turricephaly (HP:0000262)1.81817553
107Inguinal hernia (HP:0000023)1.81800026
108Flat capital femoral epiphysis (HP:0003370)1.80745920
109Dislocated radial head (HP:0003083)1.80500029
110Abnormality of carpal bone ossification (HP:0006257)1.80212399
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79542187
112Abnormality of polysaccharide metabolism (HP:0011012)1.79542187
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79542187
114Abnormal hand bone ossification (HP:0010660)1.78648482
115Striae distensae (HP:0001065)1.78613122
116Bronchomalacia (HP:0002780)1.78588931
117Disproportionate tall stature (HP:0001519)1.78497986
118Mitral regurgitation (HP:0001653)1.75947722
119Abnormality of calcium-phosphate metabolism (HP:0100530)1.75767686
120Macroorchidism (HP:0000053)1.74656623
121Ulnar bowing (HP:0003031)1.74014506
122Narrow palate (HP:0000189)1.73909392
123Abnormality of the acetabulum (HP:0003170)1.72611648
124Beaking of vertebral bodies (HP:0004568)1.71710733
125Muscle fiber splitting (HP:0003555)1.71646646
126Buphthalmos (HP:0000557)1.71635149
127Decreased circulating renin level (HP:0003351)1.71600382
128Limited hip movement (HP:0008800)1.70528103
129Hypoplasia of the iris (HP:0007676)1.69601803
130Hip contracture (HP:0003273)1.69122114
131Dysostosis multiplex (HP:0000943)1.68325094
132Renal duplication (HP:0000075)1.67903108
133Scapular winging (HP:0003691)1.67775164
134Broad long bones (HP:0005622)1.67662302
135Delayed cranial suture closure (HP:0000270)1.67208936
136Small epiphyses (HP:0010585)1.66671339
137Myocardial infarction (HP:0001658)1.66374030
138Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.65382744
139Increased variability in muscle fiber diameter (HP:0003557)1.64560180
140Abnormality of the radial head (HP:0003995)1.63804095
141Broad palm (HP:0001169)1.62819035
142Pectus carinatum (HP:0000768)1.62500768
143Femoral bowing (HP:0002980)1.61242001
144Bowel diverticulosis (HP:0005222)1.61094955
145Tibial bowing (HP:0002982)1.61016696
146Coronal craniosynostosis (HP:0004440)1.60410162
147Abnormality of Sharpey fibers (HP:0100685)1.59927404
148Ankyloglossia (HP:0010296)1.59744392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.62890443
2ERN13.38760554
3DDR22.96753801
4LATS12.84354627
5TRIB32.61521898
6MAPK152.59342082
7PDGFRA2.49601459
8TIE12.48117904
9SIK12.47599579
10RIPK12.40458186
11PTK62.19538179
12FRK2.12611994
13WNK42.05293353
14EPHB12.03907795
15TGFBR22.00202440
16EPHA31.92899277
17EEF2K1.91414765
18TAOK31.88884503
19PRKD31.84091943
20MET1.70213237
21PTK21.68718896
22EPHB21.68682415
23FER1.59485883
24PASK1.59414905
25PKN21.52859534
26TTN1.51018527
27KDR1.48900220
28DMPK1.47004942
29AKT31.40360182
30BRD41.36997335
31HIPK21.32568404
32MAP3K31.30628550
33MELK1.22791644
34WNK11.20794686
35NUAK11.18517734
36PAK31.17993117
37CAMK1G1.16233659
38CDC42BPA1.15740135
39MAP3K21.15421049
40CAMK1D1.14308910
41PAK21.14023398
42FLT31.13735621
43MYLK1.13700766
44PDGFRB1.12887469
45STK381.12280638
46STK31.07524498
47EPHA21.04140366
48FGFR21.03925678
49PRKCH1.00663997
50ERBB40.97278300
51PRKD10.96459439
52FGFR40.96052557
53MTOR0.95862388
54SMG10.91945633
55PRKD20.91460651
56STK38L0.90929631
57PIK3CA0.89972933
58GSK3A0.89576447
59PIK3CG0.88281411
60PRPF4B0.85458872
61STK390.83183054
62NTRK10.82563790
63MAPK110.81442359
64SGK30.79931946
65MAP3K60.76880519
66PAK40.76544405
67SCYL20.75305708
68TGFBR10.74143456
69MAP2K20.72116693
70EIF2AK30.69426360
71DYRK1B0.68640440
72FGFR10.67308675
73LRRK20.67116350
74CDK90.66448299
75FGFR30.65790393
76ROCK10.65397000
77PRKG20.61769865
78PDPK10.61558010
79RET0.60435790
80CSNK1A1L0.60245495
81IRAK10.59885339
82BRSK20.58632281
83BMX0.58253870
84MAP3K10.57883911
85CDK70.56443016
86NEK90.56251687
87TRPM70.55995419
88NLK0.55519224
89PTK2B0.55369325
90ERBB20.53989582
91RPS6KA20.53724034
92JAK10.51870602
93CDK120.51741490
94PRKAA20.50838777
95KIT0.50017009
96WNK30.49635931
97PRKCE0.49327614
98IGF1R0.48048494
99TESK10.47823651
100OBSCN0.47017205
101ICK0.46763097
102STK100.45719629
103SGK20.45470210
104MOS0.45202456
105MAPKAPK30.43108231
106MAP2K10.43051736
107STK240.42637877
108MAP3K100.42595645
109MAP3K130.41851477
110TYK20.41475717
111IRAK30.41452190
112KSR20.41345149
113MAPKAPK20.40952615
114MAPK70.40423687
115INSR0.40214623
116CSK0.39974376
117PRKAA10.38845377
118YES10.37694833
119MAP3K70.36165870
120CHUK0.35858361
121MST1R0.35499704
122MAP2K30.34982302
123ILK0.34701583
124CDK60.34449339
125LMTK20.33762343
126MARK20.33132229
127MAP3K140.32752287
128CDK80.32601525
129ROCK20.32452106
130BCKDK0.31665319
131LATS20.30062249
132MAPK10.30016600

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.03444426
2Protein export_Homo sapiens_hsa030603.10006166
3ECM-receptor interaction_Homo sapiens_hsa045123.06370768
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.78956435
5Protein digestion and absorption_Homo sapiens_hsa049742.61011099
6Sulfur metabolism_Homo sapiens_hsa009202.50879319
7Focal adhesion_Homo sapiens_hsa045102.11368445
8Adherens junction_Homo sapiens_hsa045201.71915944
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56114608
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55710794
11Dilated cardiomyopathy_Homo sapiens_hsa054141.54062389
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51335345
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.40017500
14Proteoglycans in cancer_Homo sapiens_hsa052051.38158682
15Amoebiasis_Homo sapiens_hsa051461.29548101
16Lysine degradation_Homo sapiens_hsa003101.27779412
17N-Glycan biosynthesis_Homo sapiens_hsa005101.27763603
18Starch and sucrose metabolism_Homo sapiens_hsa005001.20804113
19Type II diabetes mellitus_Homo sapiens_hsa049301.14452720
20* Insulin resistance_Homo sapiens_hsa049311.13963273
21Tryptophan metabolism_Homo sapiens_hsa003801.10551820
22TGF-beta signaling pathway_Homo sapiens_hsa043501.10366029
23Basal cell carcinoma_Homo sapiens_hsa052171.10358240
24* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.10150325
25Fat digestion and absorption_Homo sapiens_hsa049751.08812021
26Small cell lung cancer_Homo sapiens_hsa052221.07324733
27Bladder cancer_Homo sapiens_hsa052191.06103246
28Hippo signaling pathway_Homo sapiens_hsa043901.05941618
29* Insulin secretion_Homo sapiens_hsa049111.05654284
30Lysosome_Homo sapiens_hsa041421.05503325
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.04941198
32Hedgehog signaling pathway_Homo sapiens_hsa043401.03788088
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02926474
34Fatty acid degradation_Homo sapiens_hsa000710.99768277
35Tight junction_Homo sapiens_hsa045300.98813974
36Non-small cell lung cancer_Homo sapiens_hsa052230.95805141
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95564332
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94433729
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93723970
40Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93509784
41* Prostate cancer_Homo sapiens_hsa052150.92018482
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.90209412
43Ovarian steroidogenesis_Homo sapiens_hsa049130.89835753
44Renin-angiotensin system_Homo sapiens_hsa046140.88023933
45Fatty acid metabolism_Homo sapiens_hsa012120.87689140
46Vibrio cholerae infection_Homo sapiens_hsa051100.87633349
47Selenocompound metabolism_Homo sapiens_hsa004500.86880144
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.85439503
49Acute myeloid leukemia_Homo sapiens_hsa052210.82901101
50mTOR signaling pathway_Homo sapiens_hsa041500.81427937
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80826744
52Pancreatic secretion_Homo sapiens_hsa049720.80447801
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80128150
54Other glycan degradation_Homo sapiens_hsa005110.80043304
55* Thyroid hormone synthesis_Homo sapiens_hsa049180.79997617
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79614982
57Inositol phosphate metabolism_Homo sapiens_hsa005620.78143596
58Nitrogen metabolism_Homo sapiens_hsa009100.76845599
59Glioma_Homo sapiens_hsa052140.76674734
60FoxO signaling pathway_Homo sapiens_hsa040680.76316878
61ABC transporters_Homo sapiens_hsa020100.72812394
62Complement and coagulation cascades_Homo sapiens_hsa046100.71451052
63MicroRNAs in cancer_Homo sapiens_hsa052060.67055605
64Fructose and mannose metabolism_Homo sapiens_hsa000510.65873484
65Wnt signaling pathway_Homo sapiens_hsa043100.65421901
66Renal cell carcinoma_Homo sapiens_hsa052110.64838642
67Arginine biosynthesis_Homo sapiens_hsa002200.64672736
68PPAR signaling pathway_Homo sapiens_hsa033200.64230536
69Galactose metabolism_Homo sapiens_hsa000520.63743061
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62699859
71Insulin signaling pathway_Homo sapiens_hsa049100.62690894
72Chronic myeloid leukemia_Homo sapiens_hsa052200.62183263
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61596625
74* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61061079
75Pathways in cancer_Homo sapiens_hsa052000.61048886
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60510783
77Vitamin digestion and absorption_Homo sapiens_hsa049770.58882179
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58695139
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57783727
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57637882
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57620616
82Bile secretion_Homo sapiens_hsa049760.57106761
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56846070
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.56701611
85Rap1 signaling pathway_Homo sapiens_hsa040150.55998451
86Sphingolipid metabolism_Homo sapiens_hsa006000.55225474
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.54880630
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.54435286
89Histidine metabolism_Homo sapiens_hsa003400.53630979
90* TNF signaling pathway_Homo sapiens_hsa046680.53383842
91Notch signaling pathway_Homo sapiens_hsa043300.52630683
92Thyroid cancer_Homo sapiens_hsa052160.52198379
93GnRH signaling pathway_Homo sapiens_hsa049120.52187081
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.51432526
95* Hepatitis B_Homo sapiens_hsa051610.50776854
96ErbB signaling pathway_Homo sapiens_hsa040120.50763016
97Circadian rhythm_Homo sapiens_hsa047100.50367740
98Hepatitis C_Homo sapiens_hsa051600.50141920
99Toxoplasmosis_Homo sapiens_hsa051450.49595741
100* AMPK signaling pathway_Homo sapiens_hsa041520.48950514
101Platelet activation_Homo sapiens_hsa046110.48713635
102Arginine and proline metabolism_Homo sapiens_hsa003300.48520876
103Colorectal cancer_Homo sapiens_hsa052100.48389363
104HIF-1 signaling pathway_Homo sapiens_hsa040660.48186430
105Dorso-ventral axis formation_Homo sapiens_hsa043200.48056146
106Melanoma_Homo sapiens_hsa052180.48030062
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.47205531
108Fatty acid elongation_Homo sapiens_hsa000620.46222737
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45831363
110Steroid biosynthesis_Homo sapiens_hsa001000.45730666
111Choline metabolism in cancer_Homo sapiens_hsa052310.45045202
112Viral myocarditis_Homo sapiens_hsa054160.45036626
113* Glucagon signaling pathway_Homo sapiens_hsa049220.44654499
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44617908
115Pancreatic cancer_Homo sapiens_hsa052120.44379195
116Mineral absorption_Homo sapiens_hsa049780.44222804
117* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43980536
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43907256
119Prolactin signaling pathway_Homo sapiens_hsa049170.43590150
120Malaria_Homo sapiens_hsa051440.43527037
121Prion diseases_Homo sapiens_hsa050200.42994585
122p53 signaling pathway_Homo sapiens_hsa041150.42868723
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42640802
124Endometrial cancer_Homo sapiens_hsa052130.42031893

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