CR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.49715554
2positive regulation by symbiont of host defense response (GO:0052509)6.48003576
3modulation by symbiont of host defense response (GO:0052031)6.48003576
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.48003576
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.48003576
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.48003576
7modulation by symbiont of host immune response (GO:0052553)6.48003576
8detection of molecule of bacterial origin (GO:0032490)5.91236434
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.74229137
10negative regulation of cell killing (GO:0031342)5.74229137
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.48607947
12regulation of B cell receptor signaling pathway (GO:0050855)5.44648021
13macrophage activation involved in immune response (GO:0002281)5.35579566
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.28975935
15cellular extravasation (GO:0045123)5.19843415
16microglial cell activation (GO:0001774)5.19743785
17detection of other organism (GO:0098543)5.08183559
18detection of external biotic stimulus (GO:0098581)4.92428381
19regulation of interferon-beta biosynthetic process (GO:0045357)4.88783665
20neutrophil activation involved in immune response (GO:0002283)4.87078979
21regulation of gamma-delta T cell activation (GO:0046643)4.72721054
22response to peptidoglycan (GO:0032494)4.69849295
23negative regulation of interleukin-12 production (GO:0032695)4.53142559
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.52081792
25response to host immune response (GO:0052572)4.52081792
26leukocyte aggregation (GO:0070486)4.48367058
27macrophage activation (GO:0042116)4.43448899
28detection of bacterium (GO:0016045)4.41920036
29leukocyte migration involved in inflammatory response (GO:0002523)4.40883169
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38038588
31detection of biotic stimulus (GO:0009595)4.36096063
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.31648284
33regulation of gamma-delta T cell differentiation (GO:0045586)4.31075923
34neutrophil mediated immunity (GO:0002446)4.15224124
35antigen processing and presentation of endogenous antigen (GO:0019883)4.13211348
36response to host (GO:0075136)4.12093939
37response to host defenses (GO:0052200)4.12093939
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.12093939
39neutrophil activation (GO:0042119)4.10686951
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08672317
41positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.03180331
42respiratory burst (GO:0045730)4.02345061
43negative regulation of T cell mediated immunity (GO:0002710)3.86921168
44production of molecular mediator involved in inflammatory response (GO:0002532)3.85162644
45myeloid cell activation involved in immune response (GO:0002275)3.82658898
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.76159758
47response to interleukin-15 (GO:0070672)3.74352421
48B cell receptor signaling pathway (GO:0050853)3.74059884
49myeloid leukocyte mediated immunity (GO:0002444)3.71611428
50* negative regulation of lymphocyte mediated immunity (GO:0002707)3.70626263
51granulocyte activation (GO:0036230)3.68450089
52regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.64531183
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59175277
54immunoglobulin mediated immune response (GO:0016064)3.58159520
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43349177
56regulation of mast cell degranulation (GO:0043304)3.38700402
57positive regulation of mast cell activation (GO:0033005)3.36788216
58negative thymic T cell selection (GO:0045060)3.36364701
59activated T cell proliferation (GO:0050798)3.33234013
60negative T cell selection (GO:0043383)3.32369078
61cellular response to interleukin-15 (GO:0071350)3.30821765
62antigen processing and presentation via MHC class Ib (GO:0002475)3.30339901
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.29570403
64regulation of B cell differentiation (GO:0045577)3.29417785
65positive regulation of interferon-alpha production (GO:0032727)3.27033383
66positive regulation of B cell differentiation (GO:0045579)3.25369415
67positive thymic T cell selection (GO:0045059)3.23874522
68regulation of mast cell activation (GO:0033003)3.22748847
69* negative regulation of leukocyte mediated immunity (GO:0002704)3.19603659
70negative regulation of T-helper cell differentiation (GO:0045623)3.17951183
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17951183
72regulation of myeloid leukocyte mediated immunity (GO:0002886)3.17217491
73regulation of mast cell activation involved in immune response (GO:0033006)3.16881169
74response to muramyl dipeptide (GO:0032495)3.14289359
75dendritic cell migration (GO:0036336)3.11983238
76defense response to protozoan (GO:0042832)3.09601187
77regulation of interleukin-8 biosynthetic process (GO:0045414)3.09466868
78positive regulation of cellular amide metabolic process (GO:0034250)3.07318265
79regulation of interferon-alpha production (GO:0032647)3.06034293
80leukocyte degranulation (GO:0043299)3.04487543
81positive T cell selection (GO:0043368)3.01740766
82germinal center formation (GO:0002467)3.00763086
83myeloid leukocyte activation (GO:0002274)3.00557383
84T-helper 1 type immune response (GO:0042088)2.99893145
85neutrophil chemotaxis (GO:0030593)2.99668950
86* regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97768537
87regulation of leukocyte degranulation (GO:0043300)2.92824674
88lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92079966
89neutrophil migration (GO:1990266)2.92067118
90regulation of macrophage cytokine production (GO:0010935)2.89743233
91regulation of tolerance induction (GO:0002643)2.88999507
92regulation of interleukin-6 biosynthetic process (GO:0045408)2.87338076
93positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85090349
94cellular response to type I interferon (GO:0071357)2.85026480
95type I interferon signaling pathway (GO:0060337)2.85026480
96negative regulation of interleukin-6 production (GO:0032715)2.84582830
97negative regulation of B cell proliferation (GO:0030889)2.84491339
98response to type I interferon (GO:0034340)2.84411722
99B cell mediated immunity (GO:0019724)2.83682364
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.83535691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.58177489
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.48506626
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.46799747
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.37532546
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.18370643
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.80172255
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.50816956
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41303716
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.09090908
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08600942
11RUNX_20019798_ChIP-Seq_JUKART_Human3.06880740
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99251696
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91963476
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.82961477
15SPI1_23547873_ChIP-Seq_NB4_Human2.64952385
16SCL_19346495_ChIP-Seq_HPC-7_Human2.61372630
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.52025969
18* SPI1_23127762_ChIP-Seq_K562_Human2.49836364
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49250228
20MYB_26560356_Chip-Seq_TH2_Human2.44423734
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.43404611
22VDR_24763502_ChIP-Seq_THP-1_Human2.27004650
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24335269
24VDR_24787735_ChIP-Seq_THP-1_Human2.22007075
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07902116
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01745228
27MYB_26560356_Chip-Seq_TH1_Human2.00429277
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96255052
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94902986
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91443538
31MAF_26560356_Chip-Seq_TH1_Human1.91079259
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89863831
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.85128514
34GATA3_27048872_Chip-Seq_THYMUS_Human1.82784338
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79798600
36VDR_21846776_ChIP-Seq_THP-1_Human1.78977629
37GATA1_22025678_ChIP-Seq_K562_Human1.77876404
38UTX_26944678_Chip-Seq_JUKART_Human1.63600954
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62698296
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.61210710
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.59157125
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58734364
43PU_27001747_Chip-Seq_BMDM_Mouse1.55726105
44GATA3_26560356_Chip-Seq_TH2_Human1.55474658
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54850143
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53084577
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52177850
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51679708
49* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44136885
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40974179
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39626753
52TCF7_22412390_ChIP-Seq_EML_Mouse1.38924284
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38541500
54* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37002334
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36165088
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35880498
57GATA1_19941826_ChIP-Seq_K562_Human1.31305339
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25663605
59MYC_22102868_ChIP-Seq_BL_Human1.25136213
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21848401
61MAF_26560356_Chip-Seq_TH2_Human1.21167003
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20574349
63GATA2_19941826_ChIP-Seq_K562_Human1.19485186
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.19279261
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11675692
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10470516
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09157486
68* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08235065
69KDM2B_26808549_Chip-Seq_DND41_Human1.07216229
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06687879
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05981828
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05780882
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01282299
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00622369
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99987777
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99797093
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98999593
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98345823
79SMRT_27268052_Chip-Seq_Bcells_Human0.97320203
80GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96665621
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96496176
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92486479
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91915786
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89584852
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87625657
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82652006
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77168302
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.77072855
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76386369
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72408732
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72303888
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72207001
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71631493
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.70390338
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.70316527
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65056798
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.64350225
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.63351478
99* GATA3_26560356_Chip-Seq_TH1_Human0.63249762
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.63132164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.35221759
2MP0001835_abnormal_antigen_presentation3.80744420
3MP0003303_peritoneal_inflammation3.62788961
4MP0003436_decreased_susceptibility_to3.55607440
5MP0002419_abnormal_innate_immunity3.03966065
6MP0000685_abnormal_immune_system2.93053193
7MP0008260_abnormal_autophagy2.92311772
8MP0001800_abnormal_humoral_immune2.90347047
9MP0000569_abnormal_digit_pigmentation2.84272733
10MP0005671_abnormal_response_to2.79077894
11MP0009785_altered_susceptibility_to2.71172749
12MP0005025_abnormal_response_to2.69836731
13MP0005000_abnormal_immune_tolerance2.62896479
14MP0001790_abnormal_immune_system2.51562707
15MP0005387_immune_system_phenotype2.51562707
16MP0002723_abnormal_immune_serum2.50660316
17MP0002452_abnormal_antigen_presenting2.46441108
18MP0002420_abnormal_adaptive_immunity2.41579377
19MP0001819_abnormal_immune_cell2.38630805
20MP0003172_abnormal_lysosome_physiology2.32825153
21MP0006082_CNS_inflammation2.26574756
22MP0003300_gastrointestinal_ulcer2.15490019
23MP0003828_pulmonary_edema2.11057558
24MP0005451_abnormal_body_composition2.08823588
25MP0002148_abnormal_hypersensitivity_rea2.04875156
26MP0003763_abnormal_thymus_physiology2.02411356
27MP0005464_abnormal_platelet_physiology2.01124997
28MP0002405_respiratory_system_inflammati1.93792569
29MP0001533_abnormal_skeleton_physiology1.88310792
30MP0003191_abnormal_cellular_cholesterol1.88155417
31MP0002398_abnormal_bone_marrow1.87638556
32MP0004883_abnormal_blood_vessel1.84609866
33MP0000716_abnormal_immune_system1.84255523
34MP0004381_abnormal_hair_follicle1.80494649
35MP0002132_abnormal_respiratory_system1.72586672
36MP0001845_abnormal_inflammatory_respons1.71685349
37MP0003656_abnormal_erythrocyte_physiolo1.69068975
38MP0000689_abnormal_spleen_morphology1.61342449
39MP0002722_abnormal_immune_system1.58575706
40MP0009278_abnormal_bone_marrow1.56875719
41MP0004947_skin_inflammation1.55693529
42MP0002166_altered_tumor_susceptibility1.52493557
43MP0000465_gastrointestinal_hemorrhage1.50500505
44MP0005310_abnormal_salivary_gland1.48857667
45MP0009764_decreased_sensitivity_to1.46508605
46MP0003183_abnormal_peptide_metabolism1.46013946
47MP0010155_abnormal_intestine_physiology1.44181045
48MP0002429_abnormal_blood_cell1.44167245
49MP0003866_abnormal_defecation1.43710351
50MP0002396_abnormal_hematopoietic_system1.40254869
51MP0005397_hematopoietic_system_phenotyp1.39391321
52MP0001545_abnormal_hematopoietic_system1.39391321
53MP0000015_abnormal_ear_pigmentation1.36563781
54MP0005164_abnormal_response_to1.36511072
55MP0000703_abnormal_thymus_morphology1.35967752
56MP0002277_abnormal_respiratory_mucosa1.35885133
57MP0003690_abnormal_glial_cell1.31137850
58MP0000858_altered_metastatic_potential1.30822089
59MP0008469_abnormal_protein_level1.27090431
60MP0003787_abnormal_imprinting1.23017706
61MP0001851_eye_inflammation1.18644867
62MP0005075_abnormal_melanosome_morpholog1.17189381
63MP0003075_altered_response_to1.15612875
64MP0009333_abnormal_splenocyte_physiolog1.10088673
65MP0002998_abnormal_bone_remodeling1.07987175
66MP0005174_abnormal_tail_pigmentation1.06984379
67MP0003221_abnormal_cardiomyocyte_apopto1.04542000
68MP0000604_amyloidosis1.03993262
69MP0002006_tumorigenesis0.95706517
70MP0004484_altered_response_of0.93055327
71MP0005166_decreased_susceptibility_to0.92225396
72MP0004808_abnormal_hematopoietic_stem0.91176185
73MP0003448_altered_tumor_morphology0.89059105
74MP0005058_abnormal_lysosome_morphology0.89013001
75MP0004130_abnormal_muscle_cell0.88263666
76MP0002332_abnormal_exercise_endurance0.85229519
77MP0008004_abnormal_stomach_pH0.84729481
78MP0001853_heart_inflammation0.83279764
79MP0009763_increased_sensitivity_to0.80822438
80MP0003045_fibrosis0.78092152
81MP0000343_altered_response_to0.75781037
82MP0001663_abnormal_digestive_system0.74447282
83MP0004510_myositis0.72516620
84MP0000249_abnormal_blood_vessel0.68285322
85MP0009765_abnormal_xenobiotic_induced0.67465622
86MP0002009_preneoplasia0.66694471
87MP0000371_diluted_coat_color0.65057153
88MP0005376_homeostasis/metabolism_phenot0.64903813
89MP0002138_abnormal_hepatobiliary_system0.64520349
90MP0008874_decreased_physiological_sensi0.62979736
91MP0003091_abnormal_cell_migration0.61148192
92MP0005390_skeleton_phenotype0.61135695
93MP0003329_amyloid_beta_deposits0.60770839
94MP0001958_emphysema0.60603284
95MP0008057_abnormal_DNA_replication0.60216942
96MP0001986_abnormal_taste_sensitivity0.58069421
97MP0002133_abnormal_respiratory_system0.57034370
98MP0005388_respiratory_system_phenotype0.57034370
99MP0008877_abnormal_DNA_methylation0.55432927
100MP0003795_abnormal_bone_structure0.52376742

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.41363944
2Eczematoid dermatitis (HP:0000976)6.40658129
3Recurrent abscess formation (HP:0002722)6.16484775
4Myositis (HP:0100614)5.59673142
5Orchitis (HP:0100796)5.57187616
6Retrobulbar optic neuritis (HP:0100654)5.56585547
7Optic neuritis (HP:0100653)5.56585547
8Abnormality of macrophages (HP:0004311)4.94855329
9Recurrent gram-negative bacterial infections (HP:0005420)4.94308090
10Stomatitis (HP:0010280)4.56017908
11Gastrointestinal infarctions (HP:0005244)4.51175735
12Recurrent fungal infections (HP:0002841)4.47585604
13Elevated erythrocyte sedimentation rate (HP:0003565)4.20749411
14Recurrent skin infections (HP:0001581)4.18318889
15Keratoconjunctivitis sicca (HP:0001097)4.16461500
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.07603079
17T lymphocytopenia (HP:0005403)4.02380744
18Mediastinal lymphadenopathy (HP:0100721)3.94159605
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.91362900
20Keratoconjunctivitis (HP:0001096)3.86792596
21Abnormality of T cell number (HP:0011839)3.86719023
22Spontaneous hematomas (HP:0007420)3.83982162
23Meningitis (HP:0001287)3.83294992
24Chronic mucocutaneous candidiasis (HP:0002728)3.82926077
25Recurrent cutaneous fungal infections (HP:0011370)3.82926077
26Gingivitis (HP:0000230)3.82694948
27Encephalitis (HP:0002383)3.66346666
28Chronic obstructive pulmonary disease (HP:0006510)3.64017751
29Obstructive lung disease (HP:0006536)3.64017751
30Peritonitis (HP:0002586)3.55585466
31Vasculitis (HP:0002633)3.50719520
32Gingival bleeding (HP:0000225)3.49946975
33Arterial thrombosis (HP:0004420)3.35356489
34Urticaria (HP:0001025)3.26923845
35Hemoptysis (HP:0002105)3.21062869
36Leukocytosis (HP:0001974)3.18902121
37Prolonged bleeding time (HP:0003010)3.17635611
38Chest pain (HP:0100749)3.16973930
39Pulmonary infiltrates (HP:0002113)2.99793840
40Cellulitis (HP:0100658)2.96539573
41Recurrent viral infections (HP:0004429)2.95737914
42Abnormality of T cells (HP:0002843)2.90844485
43Epistaxis (HP:0000421)2.87545892
44Anorexia (HP:0002039)2.81321943
45Episodic fever (HP:0001954)2.77868717
46Pulmonary embolism (HP:0002204)2.71316209
47Hypochromic microcytic anemia (HP:0004840)2.58612944
48Increased IgE level (HP:0003212)2.57515245
49Abnormality of the peritoneum (HP:0002585)2.51983698
50Inflammation of the large intestine (HP:0002037)2.51754538
51Gangrene (HP:0100758)2.51560893
52Granulocytopenia (HP:0001913)2.50286113
53Amyloidosis (HP:0011034)2.50242704
54Osteomyelitis (HP:0002754)2.49916226
55Subacute progressive viral hepatitis (HP:0006572)2.43948594
56Eosinophilia (HP:0001880)2.43850671
57Hypochromic anemia (HP:0001931)2.37757326
58Gastrointestinal inflammation (HP:0004386)2.34030240
59Abnormality of the pleura (HP:0002103)2.33193797
60Viral hepatitis (HP:0006562)2.31390515
61Pustule (HP:0200039)2.30440098
62Slow saccadic eye movements (HP:0000514)2.27110523
63Panhypogammaglobulinemia (HP:0003139)2.24938535
64Abnormality of the endocardium (HP:0004306)2.23267707
65Sepsis (HP:0100806)2.19701447
66Increased IgM level (HP:0003496)2.15031943
67Recurrent bronchitis (HP:0002837)2.15029533
68Microcytic anemia (HP:0001935)2.14087498
69Lymphopenia (HP:0001888)2.13548809
70Colitis (HP:0002583)2.12554234
71Vertigo (HP:0002321)2.12477055
72Abnormality of T cell physiology (HP:0011840)2.12382928
73Acute hepatic failure (HP:0006554)2.11395471
74Keratitis (HP:0000491)2.07718536
75Abnormality of eosinophils (HP:0001879)2.07676896
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.05026625
77Glomerulopathy (HP:0100820)2.02494915
78Periodontitis (HP:0000704)2.02092943
79Autoimmune thrombocytopenia (HP:0001973)1.95674588
80Abnormal platelet volume (HP:0011876)1.93592280
81Difficulty running (HP:0009046)1.93360593
82Acne (HP:0001061)1.92879539
83Increased cerebral lipofuscin (HP:0011813)1.92590214
84Cheilitis (HP:0100825)1.92301051
85Postural instability (HP:0002172)1.90542408
86Thrombophlebitis (HP:0004418)1.88639050
87Recurrent pneumonia (HP:0006532)1.87426005
88Skin ulcer (HP:0200042)1.87053946
89Autoimmune hemolytic anemia (HP:0001890)1.85923785
90Amaurosis fugax (HP:0100576)1.83732393
91Petechiae (HP:0000967)1.82161950
92Polyneuropathy (HP:0001271)1.81431003
93Skin rash (HP:0000988)1.77876267
94IgM deficiency (HP:0002850)1.77266538
95Stomach cancer (HP:0012126)1.77175107
96Hematochezia (HP:0002573)1.76474573
97Abnormality of glycosphingolipid metabolism (HP:0004343)1.76301044
98Abnormality of glycolipid metabolism (HP:0010969)1.76301044
99Abnormality of liposaccharide metabolism (HP:0010968)1.76301044
100Agammaglobulinemia (HP:0004432)1.74973970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.99222217
2BLK3.96937282
3MAP2K33.16140197
4IRAK42.95141116
5MAP4K12.79544047
6CSK2.76151523
7TYK22.66138931
8GRK62.35122097
9FES2.34749905
10FGR2.05246644
11TXK1.96884464
12ZAP701.96477869
13JAK31.94177062
14SYK1.88362544
15MAP3K141.87891482
16BTK1.85166784
17IKBKE1.78419924
18TAOK31.77292245
19EPHB11.75286939
20HCK1.62631777
21PRPF4B1.58192442
22ERN11.51648180
23JAK21.50451497
24IRAK11.49728674
25JAK11.44996595
26MAP3K31.44324601
27MAP3K61.44088307
28YES11.43591193
29TNK21.43309733
30LYN1.42450013
31TAOK11.42128047
32MAP3K21.40614334
33PIK3CG1.35774458
34MAP3K11.31065542
35BMPR21.30575043
36TEC1.29206095
37KSR21.27679030
38MAP3K131.26656003
39ITK1.19124074
40MATK1.17109554
41IRAK21.14945804
42FGFR31.13356705
43PTK2B1.09083921
44CSF1R1.07924239
45MAP3K111.07553826
46LCK1.07254812
47MARK31.06262335
48WNK11.06117829
49FRK1.00059234
50SGK20.98854450
51MARK20.96950541
52TBK10.90894518
53LRRK20.89899703
54MAP2K40.88552115
55SGK30.88352735
56KIT0.87825078
57NLK0.85450955
58MAP3K50.84087055
59EPHA30.80518454
60PDK10.80036718
61IKBKB0.77931473
62STK100.73981989
63TGFBR20.71185283
64RAF10.70785361
65CAMKK20.69614069
66STK110.68157589
67KSR10.67663822
68PIM10.67201270
69PTK60.65824438
70STK40.65063938
71MAP2K60.62912151
72PDPK10.61985682
73MAP3K70.61864676
74FYN0.59582748
75RET0.56719786
76FGFR40.55379225
77ACVR1B0.54586362
78PRKCQ0.54072462
79HIPK20.50932044
80SIK30.50599823
81MAPK70.48927639
82SGK2230.48452147
83SGK4940.48452147
84MAPK120.47588787
85CDC42BPA0.45932557
86PRKD20.45886295
87ERBB20.45873457
88TAOK20.45430334
89GRK50.44222112
90CDK190.42676782
91TRPM70.40265661
92DAPK20.40228895
93DYRK30.39122285
94CAMK40.38745275
95DYRK1B0.35295838
96STK380.35282040
97MAPKAPK20.34515088
98GRK70.34126333
99PRKAA20.32808794
100CAMKK10.32198782

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051403.00968422
2Osteoclast differentiation_Homo sapiens_hsa043802.96388211
3Staphylococcus aureus infection_Homo sapiens_hsa051502.76752214
4B cell receptor signaling pathway_Homo sapiens_hsa046622.52103349
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.23543492
6* Tuberculosis_Homo sapiens_hsa051522.19020317
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17271609
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16729873
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.10340285
10Primary immunodeficiency_Homo sapiens_hsa053401.84614867
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83263079
12Measles_Homo sapiens_hsa051621.82740259
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82205393
14Graft-versus-host disease_Homo sapiens_hsa053321.81288338
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79264900
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.78855266
17Allograft rejection_Homo sapiens_hsa053301.76518131
18T cell receptor signaling pathway_Homo sapiens_hsa046601.71477911
19Chemokine signaling pathway_Homo sapiens_hsa040621.66310969
20Autoimmune thyroid disease_Homo sapiens_hsa053201.63799599
21* Hematopoietic cell lineage_Homo sapiens_hsa046401.60177793
22* Legionellosis_Homo sapiens_hsa051341.57812013
23Acute myeloid leukemia_Homo sapiens_hsa052211.57204562
24Toxoplasmosis_Homo sapiens_hsa051451.52792642
25* Malaria_Homo sapiens_hsa051441.51487744
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.49602918
27Non-small cell lung cancer_Homo sapiens_hsa052231.49500042
28Influenza A_Homo sapiens_hsa051641.49369106
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41559713
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34073180
31TNF signaling pathway_Homo sapiens_hsa046681.32059259
32Phagosome_Homo sapiens_hsa041451.31879645
33Platelet activation_Homo sapiens_hsa046111.31440714
34Hepatitis B_Homo sapiens_hsa051611.26573480
35Type I diabetes mellitus_Homo sapiens_hsa049401.26490240
36Antigen processing and presentation_Homo sapiens_hsa046121.20789489
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.19814402
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.16068347
39Dorso-ventral axis formation_Homo sapiens_hsa043201.13014618
40Herpes simplex infection_Homo sapiens_hsa051681.11957202
41Prolactin signaling pathway_Homo sapiens_hsa049171.11634917
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11103409
43Hepatitis C_Homo sapiens_hsa051601.06535435
44Asthma_Homo sapiens_hsa053101.06183042
45Pancreatic cancer_Homo sapiens_hsa052121.05813348
46Pertussis_Homo sapiens_hsa051331.02606476
47Viral myocarditis_Homo sapiens_hsa054161.01264110
48Apoptosis_Homo sapiens_hsa042101.00410936
49African trypanosomiasis_Homo sapiens_hsa051430.99827398
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96746468
51Chronic myeloid leukemia_Homo sapiens_hsa052200.96293482
52Renal cell carcinoma_Homo sapiens_hsa052110.94826143
53FoxO signaling pathway_Homo sapiens_hsa040680.92841998
54VEGF signaling pathway_Homo sapiens_hsa043700.90987883
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.90211223
56Salmonella infection_Homo sapiens_hsa051320.87222666
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84704790
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83847673
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82448257
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82283541
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82011011
62Endometrial cancer_Homo sapiens_hsa052130.79279047
63Rheumatoid arthritis_Homo sapiens_hsa053230.79196696
64Shigellosis_Homo sapiens_hsa051310.76312515
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75273129
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.73935071
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.72342619
68Other glycan degradation_Homo sapiens_hsa005110.71429792
69Inositol phosphate metabolism_Homo sapiens_hsa005620.68505217
70Type II diabetes mellitus_Homo sapiens_hsa049300.68317755
71GnRH signaling pathway_Homo sapiens_hsa049120.67666198
72mTOR signaling pathway_Homo sapiens_hsa041500.67652564
73HIF-1 signaling pathway_Homo sapiens_hsa040660.67077280
74Lysosome_Homo sapiens_hsa041420.65248299
75Notch signaling pathway_Homo sapiens_hsa043300.64420395
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64340903
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.62482648
78Amoebiasis_Homo sapiens_hsa051460.62246350
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61986902
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61806514
81Choline metabolism in cancer_Homo sapiens_hsa052310.61604570
82Insulin resistance_Homo sapiens_hsa049310.59247646
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57830495
84Viral carcinogenesis_Homo sapiens_hsa052030.56347934
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54982379
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54036906
87Endocytosis_Homo sapiens_hsa041440.53611460
88ErbB signaling pathway_Homo sapiens_hsa040120.51218754
89Epstein-Barr virus infection_Homo sapiens_hsa051690.50599910
90Prostate cancer_Homo sapiens_hsa052150.49670346
91MAPK signaling pathway_Homo sapiens_hsa040100.49448513
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48347490
93Glioma_Homo sapiens_hsa052140.46537838
94Colorectal cancer_Homo sapiens_hsa052100.44164402
95Regulation of autophagy_Homo sapiens_hsa041400.42970089
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42506642
97Rap1 signaling pathway_Homo sapiens_hsa040150.41360430
98Estrogen signaling pathway_Homo sapiens_hsa049150.39248011
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38354069
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.38139572

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