CPVL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)9.70245674
2cell wall macromolecule catabolic process (GO:0016998)9.70245674
3multicellular organism reproduction (GO:0032504)9.63128513
4sperm motility (GO:0030317)9.06898950
5sperm-egg recognition (GO:0035036)9.01142091
6binding of sperm to zona pellucida (GO:0007339)8.83355951
7reproduction (GO:0000003)8.21697736
8piRNA metabolic process (GO:0034587)8.12643722
9cell-cell recognition (GO:0009988)8.01665201
10acrosome assembly (GO:0001675)7.90844297
11plasma membrane fusion (GO:0045026)7.87697602
12epithelial cilium movement (GO:0003351)7.42568266
13acrosome reaction (GO:0007340)7.00310693
14axonemal dynein complex assembly (GO:0070286)6.99875850
15spermatid development (GO:0007286)6.83343827
16male meiosis (GO:0007140)6.80717681
17motile cilium assembly (GO:0044458)6.56242650
18single fertilization (GO:0007338)6.45177994
19synaptonemal complex assembly (GO:0007130)6.21388940
20neutrophil activation involved in immune response (GO:0002283)6.05909217
21synaptonemal complex organization (GO:0070193)6.04640789
22cilium movement (GO:0003341)5.93832441
23fertilization (GO:0009566)5.93720942
24regulation of cilium movement (GO:0003352)5.88418911
25microtubule depolymerization (GO:0007019)5.79974234
26cilium or flagellum-dependent cell motility (GO:0001539)5.73630057
27response to peptidoglycan (GO:0032494)5.71492383
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.70884202
29meiotic cell cycle (GO:0051321)5.25643917
30DNA methylation involved in gamete generation (GO:0043046)5.24952356
31single strand break repair (GO:0000012)5.22219005
32microtubule severing (GO:0051013)5.15871480
33negative regulation of interleukin-12 production (GO:0032695)5.15186980
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.05283880
35positive regulation by organism of defense response of other organism involved in symbiotic interact5.05283880
36modulation by symbiont of host immune response (GO:0052553)5.05283880
37positive regulation by symbiont of host defense response (GO:0052509)5.05283880
38modulation by symbiont of host defense response (GO:0052031)5.05283880
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.05283880
40spermatogenesis (GO:0007283)5.03374803
41male gamete generation (GO:0048232)5.03356793
42immunoglobulin mediated immune response (GO:0016064)4.93377303
43gamete generation (GO:0007276)4.85987968
44macrophage activation involved in immune response (GO:0002281)4.78911137
45detection of other organism (GO:0098543)4.77987370
46regulation of female gonad development (GO:2000194)4.77483283
47positive regulation of gamma-delta T cell activation (GO:0046645)4.69518384
48chromosome condensation (GO:0030261)4.69503624
49sperm capacitation (GO:0048240)4.63534976
50positive regulation of mast cell activation (GO:0033005)4.61182507
51positive regulation of mast cell degranulation (GO:0043306)4.59260901
52positive regulation of mast cell activation involved in immune response (GO:0033008)4.59260901
53detection of molecule of bacterial origin (GO:0032490)4.46510330
54detection of bacterium (GO:0016045)4.45821816
55chromosome organization involved in meiosis (GO:0070192)4.45728968
56germ cell development (GO:0007281)4.36339474
57cellular process involved in reproduction in multicellular organism (GO:0022412)4.34430789
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31630906
59DNA packaging (GO:0006323)4.27404556
60regulation of mast cell degranulation (GO:0043304)4.26921602
61detection of external biotic stimulus (GO:0098581)4.24934323
62meiotic nuclear division (GO:0007126)4.24205300
63protoporphyrinogen IX biosynthetic process (GO:0006782)4.20052751
64microglial cell activation (GO:0001774)4.12506954
65positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.08135881
66negative regulation of inclusion body assembly (GO:0090084)4.07476898
67protoporphyrinogen IX metabolic process (GO:0046501)4.06789096
68histone exchange (GO:0043486)4.04618662
69mitotic chromosome condensation (GO:0007076)4.00884117
70protein localization to chromosome, centromeric region (GO:0071459)3.99516263
71interferon-gamma-mediated signaling pathway (GO:0060333)3.98171165
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.93585898
73negative regulation of cell killing (GO:0031342)3.93585898
74detection of biotic stimulus (GO:0009595)3.92868949
75attachment of spindle microtubules to kinetochore (GO:0008608)3.92742905
76monoubiquitinated protein deubiquitination (GO:0035520)3.92225796
77B cell mediated immunity (GO:0019724)3.91463625
78regulation of mast cell activation involved in immune response (GO:0033006)3.91259878
79spermatid nucleus differentiation (GO:0007289)3.85427165
80positive regulation of leukocyte degranulation (GO:0043302)3.84776409
81multicellular organismal reproductive process (GO:0048609)3.83580442
82glycerol ether metabolic process (GO:0006662)3.83201952
83macrophage activation (GO:0042116)3.82928992
84mitotic sister chromatid segregation (GO:0000070)3.82433015
85granulocyte activation (GO:0036230)3.79727027
86regulation of inclusion body assembly (GO:0090083)3.78893455
87female gamete generation (GO:0007292)3.77858523
88protein K6-linked ubiquitination (GO:0085020)3.75302579
89male meiosis I (GO:0007141)3.74734810
90myeloid cell activation involved in immune response (GO:0002275)3.73601894
91regulation of myeloid leukocyte mediated immunity (GO:0002886)3.73410930
92gene silencing by RNA (GO:0031047)3.73322643
93regulation of mast cell activation (GO:0033003)3.69512916
94neutrophil activation (GO:0042119)3.69433248
95mitotic sister chromatid cohesion (GO:0007064)3.66067313
96positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.65666649
97lipopolysaccharide-mediated signaling pathway (GO:0031663)3.63174328
98protein K11-linked deubiquitination (GO:0035871)3.62331382
99regulation of leukocyte degranulation (GO:0043300)3.62198384
100cell recognition (GO:0008037)3.59723948
101glycosphingolipid catabolic process (GO:0046479)3.58140752
102microtubule polymerization or depolymerization (GO:0031109)3.57394481
103cellular extravasation (GO:0045123)3.57039058
104regulation of interferon-beta biosynthetic process (GO:0045357)3.56981325
105organic cation transport (GO:0015695)3.55002951
106mitotic metaphase plate congression (GO:0007080)3.55001429
107regulation of spindle checkpoint (GO:0090231)3.54078198
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53781362
109antigen processing and presentation of endogenous antigen (GO:0019883)3.51231593
110ether metabolic process (GO:0018904)3.49510527
111meiotic cell cycle process (GO:1903046)3.48376823
112cellular response to thyroid hormone stimulus (GO:0097067)3.48367782
113respiratory burst (GO:0045730)3.47680292
114regulation of centriole replication (GO:0046599)3.47361515
115regulation of acrosome reaction (GO:0060046)3.47061599
116T-helper 1 type immune response (GO:0042088)3.43487065
117DNA replication-dependent nucleosome assembly (GO:0006335)3.43150056
118DNA replication-dependent nucleosome organization (GO:0034723)3.43150056
119regulation of T cell tolerance induction (GO:0002664)3.40769495
120negative regulation of cytokine production involved in immune response (GO:0002719)3.39251807
121positive regulation of antigen processing and presentation (GO:0002579)3.38482148
122oligosaccharide catabolic process (GO:0009313)3.36124649
123regulation of microtubule-based movement (GO:0060632)3.35316517
124regulation of cytokine secretion involved in immune response (GO:0002739)3.33426826
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32841994
126response to host immune response (GO:0052572)3.32841994
127positive regulation of cellular amide metabolic process (GO:0034250)3.31645094
128regulation of antigen processing and presentation (GO:0002577)3.31227011
129regulation of tolerance induction (GO:0002643)3.28157166
130sister chromatid segregation (GO:0000819)3.26985867
131sexual reproduction (GO:0019953)3.26690013
132positive regulation of monocyte chemotaxis (GO:0090026)3.23290273
133pinocytosis (GO:0006907)3.22222944
134glycolipid catabolic process (GO:0019377)3.21727376
135cellular response to interferon-gamma (GO:0071346)3.20672700
136regulation of interleukin-8 biosynthetic process (GO:0045414)3.20272549
137positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18021694
138nuclear pore complex assembly (GO:0051292)3.16800946
139positive regulation of type 2 immune response (GO:0002830)3.16571668
140regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.16245247
141centriole replication (GO:0007099)3.16028745
142regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14615867
143calcium ion-dependent exocytosis (GO:0017156)3.14517296
144regulation of gamma-delta T cell activation (GO:0046643)3.13254806
145defense response to protozoan (GO:0042832)3.12472244
146response to muramyl dipeptide (GO:0032495)3.12338022
147positive regulation of chromosome segregation (GO:0051984)3.11708975
148genitalia morphogenesis (GO:0035112)3.11472555
149meiosis I (GO:0007127)3.11312017
150regulation of interferon-alpha production (GO:0032647)3.10748970
151regulation of B cell receptor signaling pathway (GO:0050855)3.09688685
152meiotic chromosome segregation (GO:0045132)3.09648825
153heme biosynthetic process (GO:0006783)3.09646798
154chromatin remodeling at centromere (GO:0031055)3.08936530
155gene silencing (GO:0016458)3.08351980
156metaphase plate congression (GO:0051310)3.07383343
157amino sugar catabolic process (GO:0046348)3.06682535
158negative regulation of interleukin-1 beta production (GO:0032691)3.06490719
159mitotic nuclear envelope disassembly (GO:0007077)3.06406046
160response to protozoan (GO:0001562)3.05290722
161myeloid dendritic cell activation (GO:0001773)3.04721507
162establishment of chromosome localization (GO:0051303)3.04466232
163protein localization to kinetochore (GO:0034501)3.03259253
164regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02734493
165oocyte maturation (GO:0001556)3.02628849
166regulation of T-helper 2 cell differentiation (GO:0045628)3.01634031
167multicellular organismal development (GO:0007275)3.00446060
168negative regulation of meiosis (GO:0045835)3.00109986
169antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98818902
170ventricular system development (GO:0021591)2.97873234
171neutrophil mediated immunity (GO:0002446)2.97170648
172centriole assembly (GO:0098534)2.97036741
173antigen processing and presentation via MHC class Ib (GO:0002475)2.96727853
174response to interferon-gamma (GO:0034341)2.96006276
175negative regulation of myeloid cell apoptotic process (GO:0033033)2.95982437
176protein polyglutamylation (GO:0018095)2.95433314
177lactate metabolic process (GO:0006089)2.95255549
178regulation of chromosome segregation (GO:0051983)2.94493530
179myeloid dendritic cell differentiation (GO:0043011)2.93375877
180positive regulation of interferon-alpha production (GO:0032727)2.92563636
181response to host (GO:0075136)2.91654228
182response to host defenses (GO:0052200)2.91654228
183response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91654228
184nuclear envelope disassembly (GO:0051081)2.90841260
185membrane disassembly (GO:0030397)2.90841260
186regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88779448
187myeloid leukocyte activation (GO:0002274)2.88566160
188regulation of regulated secretory pathway (GO:1903305)2.84562255
189production of molecular mediator involved in inflammatory response (GO:0002532)2.83766470
190negative regulation of erythrocyte differentiation (GO:0045647)2.82613589
191positive regulation of chemokine biosynthetic process (GO:0045080)2.81883673
192regulation of hypersensitivity (GO:0002883)2.81435195
193positive regulation of regulated secretory pathway (GO:1903307)2.80550069
194ceramide catabolic process (GO:0046514)2.79477588
195regulation of podosome assembly (GO:0071801)2.79004773
196regulation of superoxide anion generation (GO:0032928)2.76154933
197regulation of growth of symbiont in host (GO:0044126)2.75822746
198negative regulation of growth of symbiont in host (GO:0044130)2.75822746
199negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.75822746
200fusion of sperm to egg plasma membrane (GO:0007342)10.4647906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.13797256
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.85267013
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.78357197
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.55180888
5E2F7_22180533_ChIP-Seq_HELA_Human5.36235011
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.27526748
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.95857625
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72927639
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36464505
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.33918658
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32654614
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11096651
13MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01155600
14SPI1_23547873_ChIP-Seq_NB4_Human2.93365596
15EZH2_22144423_ChIP-Seq_EOC_Human2.87105432
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86482983
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84758232
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.72626327
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64624679
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63699294
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61079084
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.59522532
23AR_21909140_ChIP-Seq_LNCAP_Human2.48975387
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48735099
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41040858
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40665118
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40310565
28SPI1_23127762_ChIP-Seq_K562_Human2.38253470
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36602679
30KAP1_22055183_ChIP-Seq_ESCs_Mouse2.36263672
31STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33584391
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.33566906
33VDR_24763502_ChIP-Seq_THP-1_Human2.28164313
34BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26421529
35E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21030916
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17111578
37SALL1_21062744_ChIP-ChIP_HESCs_Human2.06867486
38VDR_21846776_ChIP-Seq_THP-1_Human2.05077386
39SCL_19346495_ChIP-Seq_HPC-7_Human2.03188332
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.99928915
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95736436
42VDR_24787735_ChIP-Seq_THP-1_Human1.92409513
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91504983
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90205560
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.86973389
46* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.83230163
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82853955
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.79058137
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77803780
50MYB_26560356_Chip-Seq_TH2_Human1.75051086
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74852660
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70946173
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70200301
54RUNX_20019798_ChIP-Seq_JUKART_Human1.70108812
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60588217
56STAT1_17558387_ChIP-Seq_HELA_Human1.59779375
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.59263494
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57892904
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56393115
60MAF_26560356_Chip-Seq_TH1_Human1.55292205
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54077701
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.53397160
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51812011
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51756781
65PU_27001747_Chip-Seq_BMDM_Mouse1.51623461
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51009601
67TFEB_21752829_ChIP-Seq_HELA_Human1.49046420
68FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48826138
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48574522
70* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47234767
71TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.47043603
72VDR_22108803_ChIP-Seq_LS180_Human1.45844458
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44058224
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43532568
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43470816
76* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43295113
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.42656805
78GATA3_21867929_ChIP-Seq_CD8_Mouse1.42522590
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42199148
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41462409
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40952309
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39115291
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39075599
84RUNX1_26923725_Chip-Seq_HPCs_Mouse1.37693762
85* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36723910
86MYB_26560356_Chip-Seq_TH1_Human1.36392912
87* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34058143
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32953924
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32798583
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32673204
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31324616
92KDM2B_26808549_Chip-Seq_REH_Human1.30593705
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30508332
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.30340420
95GATA1_22025678_ChIP-Seq_K562_Human1.29801228
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28880758
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28273287
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26697253
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25665194
100UTX_26944678_Chip-Seq_JUKART_Human1.24669122
101GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.24114396
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.21108331
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20601050
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19801406
105KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18428206
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16890092
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16805451
108GATA3_26560356_Chip-Seq_TH2_Human1.15550315
109* GATA3_27048872_Chip-Seq_THYMUS_Human1.15335488
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15224885
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14908778
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14000198
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13858643
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13582543
115GF1B_26923725_Chip-Seq_HPCs_Mouse1.13266119
116* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12892247
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11396666
118GATA1_19941827_ChIP-Seq_MEL_Mouse1.11168298
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09199438
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09119610
121MYC_22102868_ChIP-Seq_BL_Human1.08650913
122WDR5_24793694_ChIP-Seq_LNCAP_Human1.08185372
123ZNF274_21170338_ChIP-Seq_K562_Hela1.08082117
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07537483
125PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07391977
126FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06829021
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.06501414
128SPI1_26923725_Chip-Seq_HPCs_Mouse1.05621919
129RNF2_27304074_Chip-Seq_NSC_Mouse1.05482209
130ERG_20517297_ChIP-Seq_VCAP_Human1.05173412
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04925314
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04382393
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03611546
134CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03365872
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.03233378
136PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03050681
137RXR_22158963_ChIP-Seq_LIVER_Mouse1.02500961
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01219656
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.99862745
140PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98895547
141MAF_26560356_Chip-Seq_TH2_Human0.98763616
142KLF4_18555785_Chip-Seq_ESCs_Mouse0.98617226
143STAT1_20625510_ChIP-Seq_HELA_Human0.98347753
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.97927935
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97551454
146SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96498712
147P53_21459846_ChIP-Seq_SAOS-2_Human0.95618534
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.95352212
149NANOG_21062744_ChIP-ChIP_HESCs_Human0.95337380
150EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95174152
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95081708
152FUS_26573619_Chip-Seq_HEK293_Human0.94942702
153HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94770354
154GF1_26923725_Chip-Seq_HPCs_Mouse0.94238721
155TCF7_22412390_ChIP-Seq_EML_Mouse0.94176821
156THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93728940
157VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92664801
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.91801233
159LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91646632
160SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91164560
161* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90393142
162KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90067321
163KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90067321
164KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90067321
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89861076
166FLI1_21867929_ChIP-Seq_TH2_Mouse0.89265613
167CMYC_18555785_Chip-Seq_ESCs_Mouse0.88053894
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.88040116
169GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87812460
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.87659267
171* MYC_18940864_ChIP-ChIP_HL60_Human0.87364520
172EZH2_27294783_Chip-Seq_NPCs_Mouse0.86546159
173CDX2_22108803_ChIP-Seq_LS180_Human0.86235106
174P300_18555785_Chip-Seq_ESCs_Mouse0.85741631
175PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84359127
176CTCF_18555785_Chip-Seq_ESCs_Mouse0.84354054
177TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83906747
178CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83678665
179SOX9_26525672_Chip-Seq_HEART_Mouse0.82333989
180SOX2_18555785_Chip-Seq_ESCs_Mouse0.82120620
181* LXR_22158963_ChIP-Seq_LIVER_Mouse0.82035419
182SPI1_20517297_ChIP-Seq_HL60_Human0.81789893
183GATA1_19941826_ChIP-Seq_K562_Human0.80915446
184CBX2_27304074_Chip-Seq_ESCs_Mouse0.80870321
185NFYB_21822215_ChIP-Seq_K562_Human0.80247116
186TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79709514
187* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79352879
188DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79008181
189ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78684923
190STAT3_18555785_ChIP-Seq_MESCs_Mouse0.78628389
191NANOG_20526341_ChIP-Seq_ESCs_Human0.78472820
192P53_22387025_ChIP-Seq_ESCs_Mouse0.77477865
193NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76924735
194BCL6_27268052_Chip-Seq_Bcells_Human0.75677689
195EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75226802
196GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75150171
197TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75098500
198TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74870535
199SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74491307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001929_abnormal_gametogenesis4.96791265
2MP0008877_abnormal_DNA_methylation4.88020374
3MP0003698_abnormal_male_reproductive4.41685403
4MP0003303_peritoneal_inflammation4.36440436
5MP0001835_abnormal_antigen_presentation4.01095414
6MP0003718_maternal_effect3.99660887
7MP0003724_increased_susceptibility_to3.97007020
8MP0005058_abnormal_lysosome_morphology3.73723390
9MP0006082_CNS_inflammation3.67870162
10MP0004147_increased_porphyrin_level3.64815013
11MP0003436_decreased_susceptibility_to3.55663859
12MP0002653_abnormal_ependyma_morphology3.50507354
13MP0010094_abnormal_chromosome_stability3.45683075
14MP0002210_abnormal_sex_determination3.45321814
15MP0002161_abnormal_fertility/fecundity3.13206076
16MP0009785_altered_susceptibility_to3.06166230
17MP0002419_abnormal_innate_immunity3.02697781
18MP0002148_abnormal_hypersensitivity_rea2.94223817
19MP0005671_abnormal_response_to2.92006706
20MP0000653_abnormal_sex_gland2.86859092
21MP0003111_abnormal_nucleus_morphology2.82646414
22MP0003172_abnormal_lysosome_physiology2.72455357
23MP0003693_abnormal_embryo_hatching2.70220656
24MP0001145_abnormal_male_reproductive2.69686634
25MP0005025_abnormal_response_to2.66699532
26MP0005000_abnormal_immune_tolerance2.58208807
27MP0003646_muscle_fatigue2.55271638
28MP0001790_abnormal_immune_system2.40114682
29MP0005387_immune_system_phenotype2.40114682
30MP0002452_abnormal_antigen_presenting2.37833605
31MP0001800_abnormal_humoral_immune2.35306069
32MP0003077_abnormal_cell_cycle2.29448935
33MP0002723_abnormal_immune_serum2.24527610
34MP0000685_abnormal_immune_system2.21310526
35MP0003191_abnormal_cellular_cholesterol2.16787044
36MP0004957_abnormal_blastocyst_morpholog2.16531453
37MP0008058_abnormal_DNA_repair2.16006029
38MP0003300_gastrointestinal_ulcer2.12299586
39MP0008057_abnormal_DNA_replication2.09303781
40MP0003075_altered_response_to2.07144084
41MP0001819_abnormal_immune_cell2.02461685
42MP0001533_abnormal_skeleton_physiology2.00871328
43MP0005464_abnormal_platelet_physiology2.00391994
44MP0005410_abnormal_fertilization10.2716316
45MP0002420_abnormal_adaptive_immunity1.99841177
46MP0009764_decreased_sensitivity_to1.98568838
47MP0003656_abnormal_erythrocyte_physiolo1.96135061
48MP0009840_abnormal_foam_cell1.87128997
49MP0008260_abnormal_autophagy1.84573921
50MP0001853_heart_inflammation1.84009886
51MP0001845_abnormal_inflammatory_respons1.78777265
52MP0000343_altered_response_to1.78214113
53MP0003699_abnormal_female_reproductive1.77674163
54MP0001119_abnormal_female_reproductive1.77486081
55MP0010155_abnormal_intestine_physiology1.69558486
56MP0008004_abnormal_stomach_pH1.69473085
57MP0008469_abnormal_protein_level1.67192241
58MP0002405_respiratory_system_inflammati1.62832387
59MP0000604_amyloidosis1.61746143
60MP0004510_myositis1.61738060
61MP0003828_pulmonary_edema1.59829315
62MP0003690_abnormal_glial_cell1.56789040
63MP0005395_other_phenotype1.56158296
64MP0008932_abnormal_embryonic_tissue1.55048384
65MP0002998_abnormal_bone_remodeling1.51224562
66MP0004947_skin_inflammation1.50693544
67MP0000858_altered_metastatic_potential1.50196281
68MP0009333_abnormal_splenocyte_physiolog1.48721835
69MP0002282_abnormal_trachea_morphology1.45348401
70MP0005166_decreased_susceptibility_to1.45163502
71MP0000716_abnormal_immune_system1.43840956
72MP0002102_abnormal_ear_morphology1.42757675
73MP0002160_abnormal_reproductive_system1.42624871
74MP0005670_abnormal_white_adipose1.39612681
75MP0005451_abnormal_body_composition1.37653631
76MP0003183_abnormal_peptide_metabolism1.30395568
77MP0004233_abnormal_muscle_weight1.29568620
78MP0005389_reproductive_system_phenotype1.26864254
79MP0002398_abnormal_bone_marrow1.26664255
80MP0008007_abnormal_cellular_replicative1.24600227
81MP0001730_embryonic_growth_arrest1.23897426
82MP0003448_altered_tumor_morphology1.23110671
83MP0000689_abnormal_spleen_morphology1.21386345
84MP0003315_abnormal_perineum_morphology1.19663126
85MP0004264_abnormal_extraembryonic_tissu1.15731556
86MP0002429_abnormal_blood_cell1.15060613
87MP0002132_abnormal_respiratory_system1.12993801
88MP0005164_abnormal_response_to1.09275416
89MP0000350_abnormal_cell_proliferation1.08852124
90MP0002722_abnormal_immune_system1.08830716
91MP0006072_abnormal_retinal_apoptosis1.06813955
92MP0009763_increased_sensitivity_to1.05591479
93MP0000465_gastrointestinal_hemorrhage1.05392671
94MP0001697_abnormal_embryo_size1.04992981
95MP0004883_abnormal_blood_vessel1.03392221
96MP0003121_genomic_imprinting1.00113427
97MP0002085_abnormal_embryonic_tissue0.99399122
98MP0006054_spinal_hemorrhage0.97363951
99MP0003942_abnormal_urinary_system0.96740608
100MP0003123_paternal_imprinting0.94323878
101MP0010352_gastrointestinal_tract_polyps0.94214854
102MP0005380_embryogenesis_phenotype0.94202950
103MP0001672_abnormal_embryogenesis/_devel0.94202950
104MP0005167_abnormal_blood-brain_barrier0.92434156
105MP0005365_abnormal_bile_salt0.90553704
106MP0002084_abnormal_developmental_patter0.87254123
107MP0005647_abnormal_sex_gland0.86933396
108MP0000920_abnormal_myelination0.86631104
109MP0005187_abnormal_penis_morphology0.86599146
110MP0005165_increased_susceptibility_to0.86444074
111MP0003950_abnormal_plasma_membrane0.86407268
112MP0001851_eye_inflammation0.85603119
113MP0010307_abnormal_tumor_latency0.85563063
114MP0003806_abnormal_nucleotide_metabolis0.85023211
115MP0003453_abnormal_keratinocyte_physiol0.84718130
116MP0001663_abnormal_digestive_system0.83077277
117MP0005397_hematopoietic_system_phenotyp0.82332400
118MP0001545_abnormal_hematopoietic_system0.82332400
119MP0002269_muscular_atrophy0.81708224
120MP0003937_abnormal_limbs/digits/tail_de0.81011392
121MP0002254_reproductive_system_inflammat0.80739357
122MP0003866_abnormal_defecation0.80321819
123MP0003763_abnormal_thymus_physiology0.79632560
124MP0002277_abnormal_respiratory_mucosa0.79116503
125MP0003195_calcinosis0.78764782
126MP0002295_abnormal_pulmonary_circulatio0.78610813
127* MP0002080_prenatal_lethality0.78539483
128MP0000313_abnormal_cell_death0.74692039
129MP0009765_abnormal_xenobiotic_induced0.74672186
130MP0003787_abnormal_imprinting0.74042027
131MP0001919_abnormal_reproductive_system0.71723440
132MP0001915_intracranial_hemorrhage0.71637065
133MP0005319_abnormal_enzyme/_coenzyme0.71253458
134MP0005390_skeleton_phenotype0.70715658
135MP0005646_abnormal_pituitary_gland0.69329353
136MP0005584_abnormal_enzyme/coenzyme_acti0.67919701
137MP0002019_abnormal_tumor_incidence0.67077906
138MP0000579_abnormal_nail_morphology0.66553130
139MP0002332_abnormal_exercise_endurance0.65369660
140MP0003795_abnormal_bone_structure0.64466341
141MP0000609_abnormal_liver_physiology0.63652261
142MP0005623_abnormal_meninges_morphology0.63239932
143MP0003984_embryonic_growth_retardation0.61391042
144MP0000534_abnormal_ureter_morphology0.60225040
145MP0003186_abnormal_redox_activity0.58848919
146MP0002932_abnormal_joint_morphology0.58685747
147MP0001542_abnormal_bone_strength0.58624714
148MP0000249_abnormal_blood_vessel0.58595350
149MP0005408_hypopigmentation0.58268320
150MP0002088_abnormal_embryonic_growth/wei0.57104520
151MP0000703_abnormal_thymus_morphology0.56834285
152MP0005253_abnormal_eye_physiology0.56477032
153MP0003890_abnormal_embryonic-extraembry0.56151151
154MP0005636_abnormal_mineral_homeostasis0.55670411
155MP0006036_abnormal_mitochondrial_physio0.55471100
156MP0001529_abnormal_vocalization0.55029032
157MP0002166_altered_tumor_susceptibility0.55003702
158MP0009697_abnormal_copulation0.54696800
159MP0005376_homeostasis/metabolism_phenot0.53383100
160MP0005075_abnormal_melanosome_morpholog0.52939596
161MP0003786_premature_aging0.52926887
162MP0002396_abnormal_hematopoietic_system0.52917848
163MP0001765_abnormal_ion_homeostasis0.52211562
164MP0003329_amyloid_beta_deposits0.51767314
165MP0000371_diluted_coat_color0.51241910
166MP0003861_abnormal_nervous_system0.46508880
167MP0002249_abnormal_larynx_morphology0.45213651
168MP0002086_abnormal_extraembryonic_tissu0.45160274
169MP0003115_abnormal_respiratory_system0.42873165
170MP0001849_ear_inflammation0.41689448
171MP0000678_abnormal_parathyroid_gland0.40659763
172MP0000639_abnormal_adrenal_gland0.40073482
173MP0002139_abnormal_hepatobiliary_system0.39424975
174MP0000490_abnormal_crypts_of0.38596317
175MP0009278_abnormal_bone_marrow0.38537382
176MP0001764_abnormal_homeostasis0.38074477
177MP0000462_abnormal_digestive_system0.37709246
178MP0003011_delayed_dark_adaptation0.35673754
179MP0005621_abnormal_cell_physiology0.35550230
180MP0005384_cellular_phenotype0.35215380
181MP0005023_abnormal_wound_healing0.34776258
182MP0003705_abnormal_hypodermis_morpholog0.33385068
183MP0004197_abnormal_fetal_growth/weight/0.33177986
184MP0005266_abnormal_metabolism0.32228186
185MP0005310_abnormal_salivary_gland0.31408314
186MP0000358_abnormal_cell_content/0.30769109
187MP0005391_vision/eye_phenotype0.30110314

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.93448999
2Abnormal respiratory epithelium morphology (HP:0012253)7.11283928
3Abnormal respiratory motile cilium morphology (HP:0005938)7.11283928
4Male infertility (HP:0003251)7.05316786
5Chronic bronchitis (HP:0004469)7.01413526
6Infertility (HP:0000789)6.61971369
7Rhinitis (HP:0012384)6.20376610
8Abnormal ciliary motility (HP:0012262)6.04483043
9Abnormality of liposaccharide metabolism (HP:0010968)5.92278132
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.92278132
11Abnormality of glycolipid metabolism (HP:0010969)5.92278132
12Abnormality of macrophages (HP:0004311)5.50864191
13Recurrent bacterial skin infections (HP:0005406)5.39681216
14Recurrent abscess formation (HP:0002722)5.26820965
15Eczematoid dermatitis (HP:0000976)4.99886901
16Increased cerebral lipofuscin (HP:0011813)4.80777752
17Systemic lupus erythematosus (HP:0002725)4.78106831
18Nasal polyposis (HP:0100582)4.63131767
19Vacuolated lymphocytes (HP:0001922)4.60259371
20Recurrent gram-negative bacterial infections (HP:0005420)4.41912435
21Myositis (HP:0100614)4.30801986
22Obstructive lung disease (HP:0006536)4.25982933
23Chronic obstructive pulmonary disease (HP:0006510)4.25982933
24Orchitis (HP:0100796)4.22731109
25Amyloidosis (HP:0011034)4.21374685
26Optic neuritis (HP:0100653)4.16198459
27Retrobulbar optic neuritis (HP:0100654)4.16198459
28Abnormal gallbladder physiology (HP:0012438)4.13270352
29Cholecystitis (HP:0001082)4.13270352
30Abnormality of the heme biosynthetic pathway (HP:0010472)4.08239864
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.85540336
32Stomatitis (HP:0010280)3.82478762
33Loss of speech (HP:0002371)3.80572231
34Disinhibition (HP:0000734)3.73774857
35Bronchiectasis (HP:0002110)3.73232387
36Mediastinal lymphadenopathy (HP:0100721)3.72529690
37Abnormality of the nasal mucosa (HP:0000433)3.68975430
38Dysostosis multiplex (HP:0000943)3.66823530
39Bronchitis (HP:0012387)3.49289082
40Recurrent skin infections (HP:0001581)3.36821766
41Elevated erythrocyte sedimentation rate (HP:0003565)3.26689055
42Hemoptysis (HP:0002105)3.23472857
43Meningitis (HP:0001287)3.12053461
44Purpura (HP:0000979)3.08639696
45Nephronophthisis (HP:0000090)3.07517569
46Impulsivity (HP:0100710)3.07125878
47Glomerulonephritis (HP:0000099)3.03254570
48Vasculitis (HP:0002633)3.02599487
49Keratoconjunctivitis sicca (HP:0001097)3.00378454
50Recurrent fungal infections (HP:0002841)3.00237593
51Abnormal spermatogenesis (HP:0008669)3.00044113
52Pulmonary infiltrates (HP:0002113)2.94866392
53Cortical dysplasia (HP:0002539)2.94326084
54Urticaria (HP:0001025)2.88011562
55Mutism (HP:0002300)2.87326247
56Abnormality of complement system (HP:0005339)2.84268696
57Gastrointestinal infarctions (HP:0005244)2.77305466
58Abnormality of the vasculature of the conjunctiva (HP:0008054)2.75190074
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71358770
60Abnormality of polysaccharide metabolism (HP:0011012)2.71358770
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71358770
62Polyneuropathy (HP:0001271)2.69356446
63Keratoconjunctivitis (HP:0001096)2.69014042
64Gingivitis (HP:0000230)2.67908380
65Papillary thyroid carcinoma (HP:0002895)2.64097050
66Autoimmune thrombocytopenia (HP:0001973)2.63972949
67Mucopolysacchariduria (HP:0008155)2.63314891
68Urinary glycosaminoglycan excretion (HP:0003541)2.63314891
69Gangrene (HP:0100758)2.63040748
70Petechiae (HP:0000967)2.59320734
71Hepatosplenomegaly (HP:0001433)2.58541768
72Increased serum ferritin (HP:0003281)2.58466386
73Spontaneous hematomas (HP:0007420)2.57029999
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.55296146
75Recurrent cutaneous fungal infections (HP:0011370)2.53534185
76Chronic mucocutaneous candidiasis (HP:0002728)2.53534185
77Encephalitis (HP:0002383)2.53174131
78Complement deficiency (HP:0004431)2.52178110
79Birth length less than 3rd percentile (HP:0003561)2.49435835
80Myocardial infarction (HP:0001658)2.48897030
81Agnosia (HP:0010524)2.48590305
82Abnormality of the pleura (HP:0002103)2.45495203
83Recurrent otitis media (HP:0000403)2.44492388
84Medial flaring of the eyebrow (HP:0010747)2.43782233
85Abnormality of midbrain morphology (HP:0002418)2.42057570
86Molar tooth sign on MRI (HP:0002419)2.42057570
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41818258
88Abnormality of the renal medulla (HP:0100957)2.40734179
89Anorexia (HP:0002039)2.40065206
90Pulmonary embolism (HP:0002204)2.39877918
91Gingival bleeding (HP:0000225)2.38296061
92Axonal loss (HP:0003447)2.38170784
93Recurrent viral infections (HP:0004429)2.38120003
94Glomerulopathy (HP:0100820)2.37027135
95Epistaxis (HP:0000421)2.34881213
96Arterial thrombosis (HP:0004420)2.34679268
97Nausea (HP:0002018)2.30188179
98Tubulointerstitial nephritis (HP:0001970)2.27941744
99Recurrent sinusitis (HP:0011108)2.25891549
100Abnormality of iron homeostasis (HP:0011031)2.23723523
101Progressive neurologic deterioration (HP:0002344)2.23125601
102Nephroblastoma (Wilms tumor) (HP:0002667)2.21945607
103Chest pain (HP:0100749)2.21541086
104Upper motor neuron abnormality (HP:0002127)2.16828818
105Secondary amenorrhea (HP:0000869)2.15078330
106Increased IgM level (HP:0003496)2.15071342
107Ileus (HP:0002595)2.13904532
108Thrombophlebitis (HP:0004418)2.12819317
109Leukocytosis (HP:0001974)2.12564238
110T lymphocytopenia (HP:0005403)2.12334891
111Vertigo (HP:0002321)2.11816562
112Embryonal renal neoplasm (HP:0011794)2.08228464
113Episodic fever (HP:0001954)2.07116057
114Nephritis (HP:0000123)2.04832243
115Premature ovarian failure (HP:0008209)2.02567146
116Thrombocytosis (HP:0001894)2.02396760
117Increased IgE level (HP:0003212)2.01604051
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01317452
119Abnormality of the prostate (HP:0008775)2.00274771
120Memory impairment (HP:0002354)2.00174819
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4626353
122Dynein arm defect of respiratory motile cilia (HP:0012255)10.5544059
123Absent/shortened dynein arms (HP:0200106)10.5544059
124Acrocyanosis (HP:0001063)1.99481442
125Supernumerary spleens (HP:0009799)1.98946642
126Breast hypoplasia (HP:0003187)1.98319246
127Prolonged bleeding time (HP:0003010)1.98145909
128Neurofibrillary tangles (HP:0002185)1.96821476
129Congenital primary aphakia (HP:0007707)1.96564043
130Neuronal loss in central nervous system (HP:0002529)1.96063547
131Abnormality of T cell number (HP:0011839)1.95791652
132Restrictive lung disease (HP:0002091)1.94133250
133Gait imbalance (HP:0002141)1.93540680
134Tongue fasciculations (HP:0001308)1.92702832
135Basal ganglia calcification (HP:0002135)1.91733887
136Cholelithiasis (HP:0001081)1.91021702
137Facial shape deformation (HP:0011334)1.90968166
138Potter facies (HP:0002009)1.90968166
139Abnormal delayed hypersensitivity skin test (HP:0002963)1.90853072
140Absent epiphyses (HP:0010577)1.89239799
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89239799
142Diaphragmatic weakness (HP:0009113)1.88471940
143Inappropriate behavior (HP:0000719)1.87946053
144Gonadotropin excess (HP:0000837)1.87084988
145Asymmetric septal hypertrophy (HP:0001670)1.86890553
146Malnutrition (HP:0004395)1.86769686
147Abnormality of the pericardium (HP:0001697)1.86135557
148Vaginal atresia (HP:0000148)1.86134248
149Renal dysplasia (HP:0000110)1.86124289
150Genital tract atresia (HP:0001827)1.84762097
151Tubulointerstitial abnormality (HP:0001969)1.79989365
152Abnormality of the labia minora (HP:0012880)1.76023003
153Sloping forehead (HP:0000340)1.74689947
154Acute myeloid leukemia (HP:0004808)1.71758992
155Abnormal lung lobation (HP:0002101)1.70339226
156Poor coordination (HP:0002370)1.67052140
157Abnormal gallbladder morphology (HP:0012437)1.64435245
158Tubular atrophy (HP:0000092)1.63208681
159Chromsome breakage (HP:0040012)1.63147820
160Primary amenorrhea (HP:0000786)1.62549989
161Muscle fibrillation (HP:0010546)1.62072744
162Small intestinal stenosis (HP:0012848)1.61856565
163Duodenal stenosis (HP:0100867)1.61856565
164Azoospermia (HP:0000027)1.61184013
165Hypochromic microcytic anemia (HP:0004840)1.59837348
166Nephrogenic diabetes insipidus (HP:0009806)1.58997301
167Bifid tongue (HP:0010297)1.57998508
168Amaurosis fugax (HP:0100576)1.56520590
169Rhabdomyosarcoma (HP:0002859)1.55985342
170Hypoplastic labia majora (HP:0000059)1.55409414
171Chromosomal breakage induced by crosslinking agents (HP:0003221)1.52875162
172Aplasia/Hypoplasia of the uvula (HP:0010293)1.52540676
173Abnormality of the anterior horn cell (HP:0006802)1.49715445
174Degeneration of anterior horn cells (HP:0002398)1.49715445
175Aplasia/Hypoplasia of the sacrum (HP:0008517)1.48639346
176Pulmonary fibrosis (HP:0002206)1.46362208
177Abnormality of chromosome stability (HP:0003220)1.45131602
178Abnormality of the labia majora (HP:0012881)1.44626859
179Oculomotor apraxia (HP:0000657)1.43758367
180Ectopic kidney (HP:0000086)1.43654853
181Poikilocytosis (HP:0004447)1.42199209
182Short ribs (HP:0000773)1.41984154
183Patellar aplasia (HP:0006443)1.41880237
184Personality changes (HP:0000751)1.41594923
185Postaxial foot polydactyly (HP:0001830)1.40035332
186Postaxial hand polydactyly (HP:0001162)1.39802260
187Shawl scrotum (HP:0000049)1.39385633
188Heterotopia (HP:0002282)1.38708112
189Aplasia/Hypoplasia of the sternum (HP:0006714)1.38374766
190Thyroid carcinoma (HP:0002890)1.37758225
191Abnormality of permanent molar morphology (HP:0011071)1.37138156
192Abnormality of the dental root (HP:0006486)1.37138156
193Taurodontia (HP:0000679)1.37138156
194Acanthocytosis (HP:0001927)1.34995547
195Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.34409066
196Stage 5 chronic kidney disease (HP:0003774)1.33590247
197Medulloblastoma (HP:0002885)1.32451233
198Aplasia/Hypoplasia of the lens (HP:0008063)1.31708938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.34598919
2PDK47.34598919
3PRKD34.82575491
4PDK24.69417345
5BLK4.37529651
6RIPK44.04894906
7TYK23.24233819
8TESK12.93702686
9MAP3K142.78519901
10CSK2.68798859
11MAP2K32.64493737
12FGR2.60399007
13PLK42.55569910
14NME22.53034755
15MOS2.45110811
16MAP4K12.44548807
17TTK2.33158231
18TAOK32.27301203
19FES2.26709287
20BMPR22.26321481
21IRAK32.25436057
22IRAK42.25008322
23MAP3K32.18962800
24CDC72.17556050
25NEK22.16288795
26PRPF4B2.15210968
27MATK2.13398688
28GRK72.04135497
29ICK1.97033046
30CSF1R1.94954193
31ZAP701.93648223
32TBK11.91463706
33TAOK21.90110739
34ERN11.85794906
35MAP3K61.83474626
36JAK31.82113941
37STK101.78697640
38TGFBR21.78459551
39CDK191.74687551
40MAP3K111.73965875
41MAP3K131.71244333
42IKBKB1.66674438
43SYK1.62868113
44LYN1.55581245
45TXK1.52454446
46CHEK21.51021159
47EIF2AK11.48128417
48BRAF1.47864698
49IKBKE1.46107709
50ACVR1B1.39978089
51BTK1.37412092
52NEK11.35040948
53BRSK21.34198777
54STK38L1.31765633
55JAK21.29505177
56LATS21.28332853
57KIT1.24754479
58RIPK11.24277206
59JAK11.22647670
60PLK11.21756325
61LATS11.20497232
62PASK1.19760870
63HCK1.18050317
64TNK21.15094519
65MAP3K11.14671625
66STK31.12479171
67LCK1.10757740
68PNCK1.08958311
69STK381.06637598
70MELK1.04660150
71MARK31.03517824
72PINK11.00390526
73WNK40.96794044
74GRK60.95653570
75BRSK10.93893385
76MAP3K50.93670407
77TYRO30.93497559
78PTK2B0.90074565
79ITK0.89830929
80BUB10.89605590
81ERBB40.88411687
82KSR20.88127358
83DDR20.86647622
84PLK30.85545086
85TEC0.83931314
86IRAK10.83755525
87IRAK20.81524890
88YES10.79781943
89CDK80.79104010
90CDC42BPA0.72923131
91DYRK1B0.72820714
92CHEK10.72390151
93WEE10.72375648
94EEF2K0.72134208
95MAP3K80.70252115
96AURKA0.67935680
97AKT30.66390505
98ATR0.63677422
99PIM20.62899143
100ATM0.62060975
101AURKB0.61893666
102MAP3K90.61765272
103STK390.59852861
104DYRK20.58549927
105PDK10.57814538
106MAP3K120.57275109
107ARAF0.55750208
108STK240.52430713
109PIK3CG0.49024065
110PAK40.48633670
111MAPK70.48147258
112FYN0.47341984
113EPHB10.45613707
114STK160.42233928
115EGFR0.42230866
116MAP3K20.41836033
117CHUK0.41367172
118LMTK20.40854370
119CDK90.39841753
120TAOK10.39826614
121PRKAA10.39607522
122ABL10.38071589
123PAK10.37945585
124CCNB10.37507630
125SIK30.37317461
126DYRK30.37034349
127CDK120.36353550
128LRRK20.35224694
129CDK40.34749975
130RPS6KC10.34337749
131RPS6KL10.34337749
132TESK20.33624323
133MAPK120.33291298
134MAP2K60.32672181
135CDK10.32216741
136PRKCD0.32077207
137PRKD20.31937235
138CDK70.31658200
139CAMKK20.31462726
140ABL20.31337981
141PLK20.30892637
142CDK20.30067891
143MUSK0.29132138
144PIM10.28319975
145FGFR30.27032268
146PBK0.26178274
147PRKCQ0.25553125
148RAF10.25180084
149ALK0.24848504
150WNK10.24719629
151NTRK10.24454510
152MAPKAPK20.24311770
153RPS6KA60.23606787
154ADRBK20.23457942
155KDR0.23173098
156CAMK1D0.22287213
157IGF1R0.21626424
158INSR0.20597097
159CSNK1D0.19416419
160MTOR0.17621037
161VRK10.16261663
162TRPM70.16013671
163MAP3K40.13974359
164NEK60.13138378
165PRKDC0.12944752
166MAPK150.12115815
167CAMKK10.11765106
168CDK60.11345445
169MAPKAPK50.11255719
170MAPK130.09616313
171CSNK1G10.09375600
172STK40.09277096
173CSNK2A10.09202762
174PDPK10.08419859
175CSNK1G20.07507454
176NEK90.07429010
177CSNK1G30.07136498
178CDK150.06972897
179GSK3B0.06701277
180CSNK1E0.06312310
181RPS6KA30.06055416
182CDK180.04292482

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.25332514
2Asthma_Homo sapiens_hsa053104.23091924
3Vitamin B6 metabolism_Homo sapiens_hsa007504.17306392
4Allograft rejection_Homo sapiens_hsa053303.80905102
5Basal transcription factors_Homo sapiens_hsa030223.74139439
6DNA replication_Homo sapiens_hsa030303.61583372
7Graft-versus-host disease_Homo sapiens_hsa053323.59271513
8Autoimmune thyroid disease_Homo sapiens_hsa053203.45055855
9Leishmaniasis_Homo sapiens_hsa051403.39243618
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.23995036
11Cell cycle_Homo sapiens_hsa041103.20582648
12Oocyte meiosis_Homo sapiens_hsa041143.06989071
13Other glycan degradation_Homo sapiens_hsa005113.03803632
14Type I diabetes mellitus_Homo sapiens_hsa049402.84223520
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.83251206
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76508239
17Linoleic acid metabolism_Homo sapiens_hsa005912.75265874
18Fanconi anemia pathway_Homo sapiens_hsa034602.72903292
19RNA transport_Homo sapiens_hsa030132.65780314
20Pyruvate metabolism_Homo sapiens_hsa006202.61905875
21Rheumatoid arthritis_Homo sapiens_hsa053232.59650105
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.53208568
23Base excision repair_Homo sapiens_hsa034102.49174438
24Mismatch repair_Homo sapiens_hsa034302.46472613
25Osteoclast differentiation_Homo sapiens_hsa043802.40020874
26Tuberculosis_Homo sapiens_hsa051522.32661108
27RNA degradation_Homo sapiens_hsa030182.27924837
28Lysosome_Homo sapiens_hsa041422.20268532
29Viral myocarditis_Homo sapiens_hsa054162.19334469
30Homologous recombination_Homo sapiens_hsa034402.08190817
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97098594
32Ovarian steroidogenesis_Homo sapiens_hsa049131.96270772
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.93950083
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81565697
35Phagosome_Homo sapiens_hsa041451.80985059
36Dorso-ventral axis formation_Homo sapiens_hsa043201.80584498
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79415355
38Toxoplasmosis_Homo sapiens_hsa051451.70945257
39Non-homologous end-joining_Homo sapiens_hsa034501.70899837
40Pertussis_Homo sapiens_hsa051331.67836838
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66517441
42Fatty acid biosynthesis_Homo sapiens_hsa000611.66413019
43mRNA surveillance pathway_Homo sapiens_hsa030151.63018649
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61096663
45Nucleotide excision repair_Homo sapiens_hsa034201.59906554
46Hematopoietic cell lineage_Homo sapiens_hsa046401.59032001
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.57093230
48Ether lipid metabolism_Homo sapiens_hsa005651.55728707
49Pyrimidine metabolism_Homo sapiens_hsa002401.50662477
50Purine metabolism_Homo sapiens_hsa002301.50223063
51Influenza A_Homo sapiens_hsa051641.49601001
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.47568024
53Glucagon signaling pathway_Homo sapiens_hsa049221.38933709
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.36252484
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32759827
56Herpes simplex infection_Homo sapiens_hsa051681.30866473
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27471678
58Selenocompound metabolism_Homo sapiens_hsa004501.25235672
59Salmonella infection_Homo sapiens_hsa051321.24730930
60p53 signaling pathway_Homo sapiens_hsa041151.24467566
61Propanoate metabolism_Homo sapiens_hsa006401.22507383
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22423176
63African trypanosomiasis_Homo sapiens_hsa051431.19793609
64Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11395943
65Complement and coagulation cascades_Homo sapiens_hsa046101.11032836
66B cell receptor signaling pathway_Homo sapiens_hsa046621.10131749
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09435018
68Circadian rhythm_Homo sapiens_hsa047101.08768472
69Glutathione metabolism_Homo sapiens_hsa004801.05381933
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05014944
71Glycerophospholipid metabolism_Homo sapiens_hsa005641.04447875
72TNF signaling pathway_Homo sapiens_hsa046681.03179888
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02457645
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02040125
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01697358
76Biosynthesis of amino acids_Homo sapiens_hsa012300.98160759
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92689652
78Chemokine signaling pathway_Homo sapiens_hsa040620.91750023
79Measles_Homo sapiens_hsa051620.90889372
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85159323
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84911204
82Arachidonic acid metabolism_Homo sapiens_hsa005900.84369718
83Mineral absorption_Homo sapiens_hsa049780.83582127
84Collecting duct acid secretion_Homo sapiens_hsa049660.82848635
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80965116
86RNA polymerase_Homo sapiens_hsa030200.79098313
87Primary immunodeficiency_Homo sapiens_hsa053400.78033499
88Huntingtons disease_Homo sapiens_hsa050160.77751239
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76731574
90Spliceosome_Homo sapiens_hsa030400.75936294
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73684603
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72864478
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.70081157
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69930778
95Shigellosis_Homo sapiens_hsa051310.69712366
96TGF-beta signaling pathway_Homo sapiens_hsa043500.67913560
97Glycerolipid metabolism_Homo sapiens_hsa005610.67428860
98Carbon metabolism_Homo sapiens_hsa012000.65534789
99Proteasome_Homo sapiens_hsa030500.64163172
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62556411
101Pentose phosphate pathway_Homo sapiens_hsa000300.62423207
102Galactose metabolism_Homo sapiens_hsa000520.59147111
103Acute myeloid leukemia_Homo sapiens_hsa052210.57831736
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54051129
105Amoebiasis_Homo sapiens_hsa051460.53943342
106Hepatitis B_Homo sapiens_hsa051610.53315191
107Apoptosis_Homo sapiens_hsa042100.53096894
108T cell receptor signaling pathway_Homo sapiens_hsa046600.53050845
109Hepatitis C_Homo sapiens_hsa051600.52418508
110MicroRNAs in cancer_Homo sapiens_hsa052060.51617937
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50421258
112Fat digestion and absorption_Homo sapiens_hsa049750.48887160
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46879968
114VEGF signaling pathway_Homo sapiens_hsa043700.46293757
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.45488611
116Thyroid hormone synthesis_Homo sapiens_hsa049180.44808907
117mTOR signaling pathway_Homo sapiens_hsa041500.44392851
118Sphingolipid metabolism_Homo sapiens_hsa006000.44312204
119Fructose and mannose metabolism_Homo sapiens_hsa000510.43704804
120Prion diseases_Homo sapiens_hsa050200.43549307
121One carbon pool by folate_Homo sapiens_hsa006700.42916230
122Platelet activation_Homo sapiens_hsa046110.42826044
123Epstein-Barr virus infection_Homo sapiens_hsa051690.41481390
124Adherens junction_Homo sapiens_hsa045200.41134864
125Estrogen signaling pathway_Homo sapiens_hsa049150.40365649
126Hedgehog signaling pathway_Homo sapiens_hsa043400.38398139
127PPAR signaling pathway_Homo sapiens_hsa033200.38321796
128Hippo signaling pathway_Homo sapiens_hsa043900.38286457
129Renin-angiotensin system_Homo sapiens_hsa046140.37608331
130Metabolic pathways_Homo sapiens_hsa011000.37602098
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.37175665
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36887443
133Thyroid cancer_Homo sapiens_hsa052160.36263597
134HTLV-I infection_Homo sapiens_hsa051660.36251730
135Viral carcinogenesis_Homo sapiens_hsa052030.35289529
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35011003
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35001310
138Antigen processing and presentation_Homo sapiens_hsa046120.33968276
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.33298459
140Cardiac muscle contraction_Homo sapiens_hsa042600.32257799
141Systemic lupus erythematosus_Homo sapiens_hsa053220.32065413
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.31678863
143Fatty acid metabolism_Homo sapiens_hsa012120.31314694
144HIF-1 signaling pathway_Homo sapiens_hsa040660.30541925
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30311822
146Vitamin digestion and absorption_Homo sapiens_hsa049770.28753947
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28112527
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27470075
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27206144
150Pancreatic cancer_Homo sapiens_hsa052120.26239092
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23714062
152Endocytosis_Homo sapiens_hsa041440.23373474
153Inositol phosphate metabolism_Homo sapiens_hsa005620.23082150
154Malaria_Homo sapiens_hsa051440.23027663
155Bile secretion_Homo sapiens_hsa049760.22726925
156Wnt signaling pathway_Homo sapiens_hsa043100.22647700
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22455266
158Drug metabolism - other enzymes_Homo sapiens_hsa009830.22100603
159Amphetamine addiction_Homo sapiens_hsa050310.21833192
160AMPK signaling pathway_Homo sapiens_hsa041520.21522781
161Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21261468
162Vibrio cholerae infection_Homo sapiens_hsa051100.20746118
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20553766
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19961906
165Protein export_Homo sapiens_hsa030600.19686648
166Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18960879
167Legionellosis_Homo sapiens_hsa051340.18751032
168Long-term potentiation_Homo sapiens_hsa047200.18291315
169Regulation of autophagy_Homo sapiens_hsa041400.17308460
170Tight junction_Homo sapiens_hsa045300.16733499
171Primary bile acid biosynthesis_Homo sapiens_hsa001200.16248194
172Oxidative phosphorylation_Homo sapiens_hsa001900.16181238
173Prolactin signaling pathway_Homo sapiens_hsa049170.15976918
174Bladder cancer_Homo sapiens_hsa052190.15319754
175Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13031377
176Colorectal cancer_Homo sapiens_hsa052100.12667705
177GnRH signaling pathway_Homo sapiens_hsa049120.12639016
178ABC transporters_Homo sapiens_hsa020100.10194908
179Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09805963
180Fatty acid degradation_Homo sapiens_hsa000710.04859646
181Non-small cell lung cancer_Homo sapiens_hsa052230.03684236

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