CPTP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.61595474
2acrosome reaction (GO:0007340)5.05208916
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.83758029
4L-phenylalanine catabolic process (GO:0006559)4.83758029
5fusion of sperm to egg plasma membrane (GO:0007342)4.70985754
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.56994649
7L-phenylalanine metabolic process (GO:0006558)4.56994649
8sperm-egg recognition (GO:0035036)4.41217102
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.33588453
10aromatic amino acid family catabolic process (GO:0009074)4.22982039
11binding of sperm to zona pellucida (GO:0007339)4.18200337
12acrosome assembly (GO:0001675)4.12050533
13coenzyme catabolic process (GO:0009109)4.08761904
14cofactor catabolic process (GO:0051187)3.97112263
15indole-containing compound catabolic process (GO:0042436)3.89696463
16indolalkylamine catabolic process (GO:0046218)3.89696463
17tryptophan catabolic process (GO:0006569)3.89696463
18cell-cell recognition (GO:0009988)3.84824414
19protein localization to endosome (GO:0036010)3.83018781
20spermatid development (GO:0007286)3.75847263
21tryptophan metabolic process (GO:0006568)3.75283811
22kynurenine metabolic process (GO:0070189)3.75209303
23oxaloacetate metabolic process (GO:0006107)3.74091889
24urea metabolic process (GO:0019627)3.70511321
25urea cycle (GO:0000050)3.70511321
26NADH metabolic process (GO:0006734)3.69318814
27negative regulation of erythrocyte differentiation (GO:0045647)3.65813978
28cell wall macromolecule catabolic process (GO:0016998)3.65710605
29cell wall macromolecule metabolic process (GO:0044036)3.65710605
30regulation of early endosome to late endosome transport (GO:2000641)3.64158564
31cysteine metabolic process (GO:0006534)3.63440668
32multicellular organism reproduction (GO:0032504)3.62468523
33plasma membrane fusion (GO:0045026)3.61036120
34high-density lipoprotein particle remodeling (GO:0034375)3.54047487
35regulation of cilium movement (GO:0003352)3.53146034
36GDP-mannose metabolic process (GO:0019673)3.52033711
37barbed-end actin filament capping (GO:0051016)3.51696234
38epithelial cilium movement (GO:0003351)3.51228597
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.51045398
40cilium or flagellum-dependent cell motility (GO:0001539)3.49242494
41creatine metabolic process (GO:0006600)3.47448150
42negative regulation of cell size (GO:0045792)3.40993141
43aldehyde catabolic process (GO:0046185)3.39150115
44axonemal dynein complex assembly (GO:0070286)3.38949908
45regulation of cholesterol esterification (GO:0010872)3.37153638
46nitrogen cycle metabolic process (GO:0071941)3.37138156
47sulfur amino acid catabolic process (GO:0000098)3.36819739
48cellular ketone body metabolic process (GO:0046950)3.36604959
49motile cilium assembly (GO:0044458)3.34920950
50lysine metabolic process (GO:0006553)3.34012838
51lysine catabolic process (GO:0006554)3.34012838
52protein retention in ER lumen (GO:0006621)3.32863553
53succinate metabolic process (GO:0006105)3.31744445
54organic cation transport (GO:0015695)3.31712184
55serine family amino acid catabolic process (GO:0009071)3.29959254
56proline biosynthetic process (GO:0006561)3.29170489
57peroxisome fission (GO:0016559)3.26845904
58Golgi transport vesicle coating (GO:0048200)3.26336281
59COPI coating of Golgi vesicle (GO:0048205)3.26336281
60ATP hydrolysis coupled proton transport (GO:0015991)3.22354432
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.22354432
62aromatic amino acid family metabolic process (GO:0009072)3.19301701
63piRNA metabolic process (GO:0034587)3.19296754
64regulation of inclusion body assembly (GO:0090083)3.17762932
65fructose metabolic process (GO:0006000)3.17686700
66reproduction (GO:0000003)3.17525908
67positive regulation of Cdc42 GTPase activity (GO:0043089)3.17172581
68alditol metabolic process (GO:0019400)3.16317344
69aspartate family amino acid catabolic process (GO:0009068)3.15757474
70negative regulation of fibrinolysis (GO:0051918)3.13815540
71apoptotic process involved in morphogenesis (GO:0060561)3.12299132
72urate metabolic process (GO:0046415)3.12016359
73focal adhesion assembly (GO:0048041)3.08986406
74cell-substrate adherens junction assembly (GO:0007045)3.08986406
75tricarboxylic acid cycle (GO:0006099)3.05931882
76S-adenosylmethionine metabolic process (GO:0046500)3.04575622
77regulation of protein activation cascade (GO:2000257)3.03978134
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.03889508
79complement activation, alternative pathway (GO:0006957)3.02162976
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01602887
81glyoxylate metabolic process (GO:0046487)3.01592548
82protein-lipid complex remodeling (GO:0034368)3.00283005
83macromolecular complex remodeling (GO:0034367)3.00283005
84plasma lipoprotein particle remodeling (GO:0034369)3.00283005
85adherens junction assembly (GO:0034333)3.00134877
86positive regulation of lipoprotein lipase activity (GO:0051006)2.99470674
87positive regulation of triglyceride lipase activity (GO:0061365)2.99470674
88alpha-amino acid catabolic process (GO:1901606)2.99072255
89bile acid biosynthetic process (GO:0006699)2.98636495
90phospholipid efflux (GO:0033700)2.98296698
91male meiosis (GO:0007140)2.97498359
92single fertilization (GO:0007338)2.97283627
93sperm capacitation (GO:0048240)2.96391844
94negative regulation of cholesterol transport (GO:0032375)2.92864707
95negative regulation of sterol transport (GO:0032372)2.92864707
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87490083
97chaperone-mediated protein transport (GO:0072321)2.87399702
98stress fiber assembly (GO:0043149)2.87126120
99regulation of complement activation (GO:0030449)2.86709758
100amino-acid betaine metabolic process (GO:0006577)2.86054354
101cell-substrate junction assembly (GO:0007044)2.85406540
102hexose biosynthetic process (GO:0019319)2.84646836
103reverse cholesterol transport (GO:0043691)2.83400875
104glycerol ether metabolic process (GO:0006662)2.83398324
105arginine metabolic process (GO:0006525)2.83307334
106low-density lipoprotein particle remodeling (GO:0034374)2.80948860
107desmosome organization (GO:0002934)2.80906270
108cellular amino acid catabolic process (GO:0009063)2.79672805
109negative regulation of inclusion body assembly (GO:0090084)2.79325631
110drug catabolic process (GO:0042737)2.79154774
111synaptonemal complex organization (GO:0070193)2.79153883
112ketone body metabolic process (GO:1902224)2.79023786
113tyrosine metabolic process (GO:0006570)2.78744758
114glycerol metabolic process (GO:0006071)2.78285691
115protein carboxylation (GO:0018214)2.77672681
116peptidyl-glutamic acid carboxylation (GO:0017187)2.77672681
117glutamate metabolic process (GO:0006536)2.75415180
118muscle filament sliding (GO:0030049)2.73269592
119actin-myosin filament sliding (GO:0033275)2.73269592
120serine family amino acid metabolic process (GO:0009069)2.72105305
121regulation of fibrinolysis (GO:0051917)2.72010449
122indolalkylamine metabolic process (GO:0006586)2.71563019
123regulation of glucose import in response to insulin stimulus (GO:2001273)2.71400605
124NIK/NF-kappaB signaling (GO:0038061)2.71195915
125regulation of triglyceride catabolic process (GO:0010896)2.69939639
126cellular modified amino acid catabolic process (GO:0042219)2.68788254
127mannose metabolic process (GO:0006013)2.68632944
128endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.68235061
129modulation by symbiont of host cellular process (GO:0044068)2.67056302
130negative regulation of necroptotic process (GO:0060546)2.66437555
131positive regulation of myotube differentiation (GO:0010831)2.64370221
132activation of MAPKKK activity (GO:0000185)2.63401100
133proline metabolic process (GO:0006560)2.62054357
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61402973
135positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59776995
136activation of Rac GTPase activity (GO:0032863)2.59524699
137pinocytosis (GO:0006907)2.57119396
138skeletal muscle contraction (GO:0003009)2.56097566
139hemidesmosome assembly (GO:0031581)2.55251064
140basement membrane organization (GO:0071711)2.53469723
141regulation of necrotic cell death (GO:0010939)2.52914431
142semaphorin-plexin signaling pathway (GO:0071526)2.51225253
143glycosphingolipid catabolic process (GO:0046479)2.50911766
144regulation of mammary gland epithelial cell proliferation (GO:0033599)2.47952741
145sarcoplasmic reticulum calcium ion transport (GO:0070296)2.46609456
146pentose-phosphate shunt (GO:0006098)2.46562094
147positive regulation of receptor recycling (GO:0001921)2.44274702
148modulation by virus of host process (GO:0019054)2.44068909
149gluconeogenesis (GO:0006094)2.43304963
150adenosine receptor signaling pathway (GO:0001973)2.43078638
151regulation of cholesterol homeostasis (GO:2000188)2.40522035
152epithelial cell-cell adhesion (GO:0090136)2.39890095
153glucose catabolic process (GO:0006007)2.39183788
154monosaccharide biosynthetic process (GO:0046364)2.35878540
155positive regulation of protein dephosphorylation (GO:0035307)2.33110562
156UV protection (GO:0009650)2.32920362
157cell volume homeostasis (GO:0006884)2.32328965
158amyloid precursor protein catabolic process (GO:0042987)2.32113902
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31546764
160adhesion of symbiont to host (GO:0044406)2.30925644
161regulation of cholesterol biosynthetic process (GO:0045540)2.30221585
162antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29662844
163cytoskeletal anchoring at plasma membrane (GO:0007016)2.28377098
164cellular response to virus (GO:0098586)2.28327603
165regulation of necroptotic process (GO:0060544)2.27114779
166regulation of pseudopodium assembly (GO:0031272)2.26266889
167negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.24990002
168glycolipid catabolic process (GO:0019377)2.24371291
1693-UTR-mediated mRNA stabilization (GO:0070935)2.24366033
170negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.24098423
171regulation of skeletal muscle contraction (GO:0014819)2.23977996
172amyloid precursor protein metabolic process (GO:0042982)2.23497528
173sarcomere organization (GO:0045214)2.22435554
174cardiac muscle contraction (GO:0060048)2.22147240
175virion attachment to host cell (GO:0019062)2.21472542
176adhesion of symbiont to host cell (GO:0044650)2.21472542
177atrioventricular valve morphogenesis (GO:0003181)2.20317968
178negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.19785470
179response to laminar fluid shear stress (GO:0034616)2.19363451
180antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.18260947
181protein targeting to plasma membrane (GO:0072661)2.17612859
1824-hydroxyproline metabolic process (GO:0019471)2.17318551
183regulation of extracellular matrix disassembly (GO:0010715)2.17001112
184glucose 6-phosphate metabolic process (GO:0051156)2.16566446
185regulation of cholesterol metabolic process (GO:0090181)2.16011100
186negative regulation of viral release from host cell (GO:1902187)2.15751135
187modulation by virus of host morphology or physiology (GO:0019048)2.15458275
188tricarboxylic acid metabolic process (GO:0072350)2.14392034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.92510682
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.73126542
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.03480194
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.43406411
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.41336145
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.25508998
7LXR_22292898_ChIP-Seq_THP-1_Human3.06048100
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.98475017
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.93625435
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.92246974
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.91962496
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.85883563
13VDR_21846776_ChIP-Seq_THP-1_Human2.83223150
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.64901069
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.63356896
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.50824616
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37363080
18RACK7_27058665_Chip-Seq_MCF-7_Human2.36656914
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36046846
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29703217
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29453952
22TAF15_26573619_Chip-Seq_HEK293_Human2.21986362
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14066881
24MYC_22102868_ChIP-Seq_BL_Human2.08515601
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08213942
26VDR_22108803_ChIP-Seq_LS180_Human2.07350243
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01826857
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01598354
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.99901190
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99584995
31KDM2B_26808549_Chip-Seq_DND41_Human1.97517777
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97287694
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97041219
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.91005396
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89639323
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89243723
37P68_20966046_ChIP-Seq_HELA_Human1.88227324
38TCF7_22412390_ChIP-Seq_EML_Mouse1.82463964
39ZNF263_19887448_ChIP-Seq_K562_Human1.81510251
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.73547202
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72878894
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71255032
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.68931497
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68712815
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.67193173
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.65443638
47KDM2B_26808549_Chip-Seq_K562_Human1.59318290
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58998373
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.54863838
50SMC4_20622854_ChIP-Seq_HELA_Human1.53827781
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.52650669
52VDR_24763502_ChIP-Seq_THP-1_Human1.52324672
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50799417
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50704817
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50555899
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49695074
57BCOR_27268052_Chip-Seq_Bcells_Human1.48684246
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46272413
59HTT_18923047_ChIP-ChIP_STHdh_Human1.45501656
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44889327
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44811541
62CTCF_27219007_Chip-Seq_Bcells_Human1.44443052
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42902953
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.41955285
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.41754096
66MAF_26560356_Chip-Seq_TH1_Human1.41517988
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41399505
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.40696763
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40436621
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40296357
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39576963
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39307557
73CREB1_26743006_Chip-Seq_LNCaP_Human1.38499461
74MAF_26560356_Chip-Seq_TH2_Human1.38327429
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37415471
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36639357
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35908031
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35138169
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34209897
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34199194
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33893086
82GATA3_21867929_ChIP-Seq_CD8_Mouse1.31838280
83RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31825403
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29482709
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28783627
86ATF3_27146783_Chip-Seq_COLON_Human1.28393440
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27887526
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26791433
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25719934
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.24777221
91SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24103842
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.23971725
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23318104
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21644281
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.21226835
96SA1_27219007_Chip-Seq_Bcells_Human1.21160367
97P53_21459846_ChIP-Seq_SAOS-2_Human1.20739272
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19881939
99STAT1_17558387_ChIP-Seq_HELA_Human1.19671770
100UTX_26944678_Chip-Seq_JUKART_Human1.18429125
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16976797
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16497390
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.16406943
104E2F1_20622854_ChIP-Seq_HELA_Human1.15510982
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15263110
106CTCF_21964334_Chip-Seq_Bcells_Human1.15247766
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14593259
108ERG_20517297_ChIP-Seq_VCAP_Human1.13676240
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13631839
110FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13236984
111NCOR1_26117541_ChIP-Seq_K562_Human1.13140433
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12335485
113P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12230903
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11760031
115PHF8_20622854_ChIP-Seq_HELA_Human1.10900879
116CLOCK_20551151_ChIP-Seq_293T_Human1.10841556
117GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10482132
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.10471869
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10178275
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09322750
121TP53_22127205_ChIP-Seq_IMR90_Human1.08817525
122OCT4_20526341_ChIP-Seq_ESCs_Human1.08186766
123GATA1_19941827_ChIP-Seq_MEL_Mouse1.08041718
124TP63_22573176_ChIP-Seq_HFKS_Human1.07721831
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.07564404
126CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07386062
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07335290
128SOX2_21211035_ChIP-Seq_LN229_Human1.06433093
129ETS1_21867929_ChIP-Seq_TH2_Mouse1.06119648
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04912236
131GATA3_21867929_ChIP-Seq_TH1_Mouse1.04426638
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.04092870
133CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03957123
134NANOG_20526341_ChIP-Seq_ESCs_Human1.03727118
135SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03724473
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03528934
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02373924
138CTCF_20526341_ChIP-Seq_ESCs_Human1.01292234
139JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01006399
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00916149
141STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00586823
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.99874462
143FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99053687
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99011218
145LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.98879837
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98784097
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97938866
148FLI1_21867929_ChIP-Seq_CD8_Mouse0.97529667
149REST_21632747_ChIP-Seq_MESCs_Mouse0.96803009
150CBP_20019798_ChIP-Seq_JUKART_Human0.96527076
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96527076
152SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95736181
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95706603
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.94449659
155TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94146696
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.93975864
157NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93958536
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93546138
159DCP1A_22483619_ChIP-Seq_HELA_Human0.93531044
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92993809
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92723811
162ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92655093
163CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91109909
164GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.90669499
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90256543
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90185122
167SPI1_26923725_Chip-Seq_HPCs_Mouse0.89866628
168TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89686041
169ELF1_20517297_ChIP-Seq_JURKAT_Human0.88294422
170ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87014245
171AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85652947
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85156403
173CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84853926
174MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84183359
175ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84153347
176BCL6_27268052_Chip-Seq_Bcells_Human0.83821105
177YY1_21170310_ChIP-Seq_MESCs_Mouse0.83546498
178MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83444866
179NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83402119
180KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83275233
181CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83144443
182MYC_19829295_ChIP-Seq_ESCs_Human0.82045214
183SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81380337

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.95703905
2MP0005360_urolithiasis5.85898428
3MP0005410_abnormal_fertilization5.59733160
4MP0005085_abnormal_gallbladder_physiolo4.26360046
5MP0005365_abnormal_bile_salt3.75048449
6MP0003806_abnormal_nucleotide_metabolis3.73207408
7MP0003705_abnormal_hypodermis_morpholog3.69079989
8MP0008875_abnormal_xenobiotic_pharmacok3.54313554
9MP0000751_myopathy3.40981099
10MP0005058_abnormal_lysosome_morphology3.09992080
11MP0005083_abnormal_biliary_tract2.65519123
12MP0005451_abnormal_body_composition2.61390482
13MP0003252_abnormal_bile_duct2.56218955
14MP0009840_abnormal_foam_cell2.47352309
15MP0010329_abnormal_lipoprotein_level2.34194050
16MP0001764_abnormal_homeostasis2.29309224
17MP0005332_abnormal_amino_acid2.28870729
18MP0004510_myositis2.27681953
19MP0002736_abnormal_nociception_after2.17150423
20MP0003646_muscle_fatigue2.13680553
21MP0003698_abnormal_male_reproductive2.03002574
22MP0004858_abnormal_nervous_system2.01361496
23MP0001968_abnormal_touch/_nociception1.99931032
24MP0003191_abnormal_cellular_cholesterol1.97278841
25MP0003453_abnormal_keratinocyte_physiol1.95744645
26MP0001666_abnormal_nutrient_absorption1.90631468
27MP0003303_peritoneal_inflammation1.90596988
28MP0000678_abnormal_parathyroid_gland1.89077846
29MP0005330_cardiomyopathy1.88506269
30MP0002876_abnormal_thyroid_physiology1.87517172
31MP0003329_amyloid_beta_deposits1.87313117
32MP0000749_muscle_degeneration1.86157131
33MP0000747_muscle_weakness1.84920173
34MP0003436_decreased_susceptibility_to1.80646510
35MP0003195_calcinosis1.79807745
36MP0004185_abnormal_adipocyte_glucose1.79127262
37MP0005636_abnormal_mineral_homeostasis1.78573387
38MP0006276_abnormal_autonomic_nervous1.77652924
39MP0001986_abnormal_taste_sensitivity1.75755797
40MP0001929_abnormal_gametogenesis1.75022487
41MP0001849_ear_inflammation1.74783156
42MP0003656_abnormal_erythrocyte_physiolo1.74530539
43MP0000604_amyloidosis1.71859064
44MP0000750_abnormal_muscle_regeneration1.71206867
45MP0006036_abnormal_mitochondrial_physio1.68365047
46MP0003566_abnormal_cell_adhesion1.67223308
47MP0005084_abnormal_gallbladder_morpholo1.65175147
48MP0000759_abnormal_skeletal_muscle1.63406493
49MP0005666_abnormal_adipose_tissue1.63403403
50MP0005670_abnormal_white_adipose1.62364892
51MP0009697_abnormal_copulation1.58987069
52MP0004087_abnormal_muscle_fiber1.57274865
53MP0005409_darkened_coat_color1.56352722
54MP0005375_adipose_tissue_phenotype1.52021658
55MP0000003_abnormal_adipose_tissue1.48247472
56MP0005584_abnormal_enzyme/coenzyme_acti1.46155719
57MP0004130_abnormal_muscle_cell1.45859781
58MP0004947_skin_inflammation1.45724625
59MP0003186_abnormal_redox_activity1.42562180
60MP0004019_abnormal_vitamin_homeostasis1.42081099
61MP0002735_abnormal_chemical_nociception1.41761578
62MP0003718_maternal_effect1.39607782
63MP0009278_abnormal_bone_marrow1.38266044
64MP0002138_abnormal_hepatobiliary_system1.38120000
65MP0004036_abnormal_muscle_relaxation1.36966120
66MP0002118_abnormal_lipid_homeostasis1.36679263
67MP0005319_abnormal_enzyme/_coenzyme1.36675508
68MP0006035_abnormal_mitochondrial_morpho1.35491146
69MP0000858_altered_metastatic_potential1.35389280
70MP0003300_gastrointestinal_ulcer1.33774210
71MP0005501_abnormal_skin_physiology1.33560525
72MP0002877_abnormal_melanocyte_morpholog1.31117140
73MP0003172_abnormal_lysosome_physiology1.31036373
74MP0009333_abnormal_splenocyte_physiolog1.30790036
75MP0000609_abnormal_liver_physiology1.29309772
76MP0003011_delayed_dark_adaptation1.28733447
77MP0008438_abnormal_cutaneous_collagen1.28324217
78MP0003279_aneurysm1.25706089
79MP0005076_abnormal_cell_differentiation1.25072591
80MP0003183_abnormal_peptide_metabolism1.24481029
81MP0002161_abnormal_fertility/fecundity1.24048732
82MP0004270_analgesia1.22895817
83MP0003091_abnormal_cell_migration1.21236832
84MP0003075_altered_response_to1.20231455
85MP0009046_muscle_twitch1.19353216
86MP0001765_abnormal_ion_homeostasis1.19256766
87MP0000733_abnormal_muscle_development1.19190076
88MP0004264_abnormal_extraembryonic_tissu1.18483293
89MP0005023_abnormal_wound_healing1.14245353
90MP0001873_stomach_inflammation1.13156795
91MP0003879_abnormal_hair_cell1.13050336
92MP0002653_abnormal_ependyma_morphology1.10756338
93MP0002106_abnormal_muscle_physiology1.09476998
94MP0002796_impaired_skin_barrier1.09180261
95MP0001348_abnormal_lacrimal_gland1.09038668
96MP0002249_abnormal_larynx_morphology1.07308355
97MP0005166_decreased_susceptibility_to1.06751112
98MP0006138_congestive_heart_failure1.06192352
99MP0002734_abnormal_mechanical_nocicepti1.05890658
100MP0009643_abnormal_urine_homeostasis1.04115186
101MP0001958_emphysema1.03856971
102MP0005376_homeostasis/metabolism_phenot1.03473169
103MP0002269_muscular_atrophy1.03350598
104MP0010630_abnormal_cardiac_muscle1.02435724
105MP0000343_altered_response_to1.02167712
106MP0000685_abnormal_immune_system0.98680212
107MP0005165_increased_susceptibility_to0.98419238
108MP0002060_abnormal_skin_morphology0.97099566
109MP0005266_abnormal_metabolism0.96719888
110MP0005025_abnormal_response_to0.96368401
111MP0001529_abnormal_vocalization0.95953892
112MP0004782_abnormal_surfactant_physiolog0.95282961
113MP0005464_abnormal_platelet_physiology0.94654533
114MP0010155_abnormal_intestine_physiology0.93781939
115MP0008877_abnormal_DNA_methylation0.91611792
116MP0004147_increased_porphyrin_level0.91518441
117MP0001661_extended_life_span0.90484253
118MP0002972_abnormal_cardiac_muscle0.88376080
119MP0000681_abnormal_thyroid_gland0.87099863
120MP0004145_abnormal_muscle_electrophysio0.86958754
121MP0000013_abnormal_adipose_tissue0.86542408
122MP0002163_abnormal_gland_morphology0.85902085
123MP0005408_hypopigmentation0.84844971
124MP0002733_abnormal_thermal_nociception0.83710352
125MP0005369_muscle_phenotype0.83667906
126MP0002210_abnormal_sex_determination0.83271441
127MP0003868_abnormal_feces_composition0.82672121
128MP0004272_abnormal_basement_membrane0.82477473
129MP0001533_abnormal_skeleton_physiology0.81988613
130MP0001216_abnormal_epidermal_layer0.81592505
131MP0003828_pulmonary_edema0.80963160
132MP0009931_abnormal_skin_appearance0.80416203
133MP0005257_abnormal_intraocular_pressure0.79827782
134MP0000358_abnormal_cell_content/0.79738498
135MP0002998_abnormal_bone_remodeling0.79581080
136MP0005647_abnormal_sex_gland0.79335674
137MP0001145_abnormal_male_reproductive0.77950964
138MP0002419_abnormal_innate_immunity0.76641135
139MP0000653_abnormal_sex_gland0.76342538
140MP0010386_abnormal_urinary_bladder0.76116308
141MP0002971_abnormal_brown_adipose0.75693383
142MP0002272_abnormal_nervous_system0.75247602
143MP0001790_abnormal_immune_system0.72569583
144MP0005387_immune_system_phenotype0.72569583
145MP0004142_abnormal_muscle_tone0.72190122
146MP0008872_abnormal_physiological_respon0.72096452
147MP0009642_abnormal_blood_homeostasis0.72087357
148MP0001756_abnormal_urination0.70413881
149MP0002089_abnormal_postnatal_growth/wei0.70103501
150MP0002933_joint_inflammation0.70057708
151MP0001970_abnormal_pain_threshold0.69954464
152MP0005620_abnormal_muscle_contractility0.69874299
153MP0002148_abnormal_hypersensitivity_rea0.69688982
154MP0009764_decreased_sensitivity_to0.68378473
155MP0003693_abnormal_embryo_hatching0.67803531
156MP0008469_abnormal_protein_level0.67300081
157MP0002332_abnormal_exercise_endurance0.67206149
158MP0010234_abnormal_vibrissa_follicle0.66128339
159MP0000598_abnormal_liver_morphology0.64075611
160MP0000538_abnormal_urinary_bladder0.63717462
161MP0005535_abnormal_body_temperature0.63192461
162MP0002160_abnormal_reproductive_system0.62662334
163MP0010368_abnormal_lymphatic_system0.61497269
164MP0002064_seizures0.61384826
165MP0005379_endocrine/exocrine_gland_phen0.59900225
166MP0003635_abnormal_synaptic_transmissio0.59408391
167MP0003880_abnormal_central_pattern0.59289412
168MP0005395_other_phenotype0.58915467
169MP0002078_abnormal_glucose_homeostasis0.58448379
170MP0001984_abnormal_olfaction0.58053128
171MP0008260_abnormal_autophagy0.55537710
172MP0004233_abnormal_muscle_weight0.55315554
173MP0009745_abnormal_behavioral_response0.52863138
174MP0000230_abnormal_systemic_arterial0.52301972
175MP0001905_abnormal_dopamine_level0.50863379
176MP0008874_decreased_physiological_sensi0.50620120
177MP0002132_abnormal_respiratory_system0.49968554

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.97761708
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.22477533
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.18633674
4Absent/shortened dynein arms (HP:0200106)4.18633674
5Distal lower limb muscle weakness (HP:0009053)4.06085840
6Cholecystitis (HP:0001082)3.88622971
7Abnormal gallbladder physiology (HP:0012438)3.88622971
8Hypobetalipoproteinemia (HP:0003563)3.86793136
9Exercise-induced myalgia (HP:0003738)3.84361586
10Increased connective tissue (HP:0009025)3.82032874
11Deep venous thrombosis (HP:0002625)3.79089487
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79082791
13Myopathic facies (HP:0002058)3.65307393
14Prolonged partial thromboplastin time (HP:0003645)3.58318659
15Type 1 muscle fiber predominance (HP:0003803)3.56023205
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.53905250
17Increased serum pyruvate (HP:0003542)3.52344503
18Abnormality of glycolysis (HP:0004366)3.52344503
19Intrahepatic cholestasis (HP:0001406)3.48700381
20Distal lower limb amyotrophy (HP:0008944)3.36523927
21Infertility (HP:0000789)3.33350210
22Muscle fiber inclusion bodies (HP:0100299)3.33314148
23Asymmetric septal hypertrophy (HP:0001670)3.31901253
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.26860821
25Xanthomatosis (HP:0000991)3.23731094
26Gout (HP:0001997)3.22200038
27Nemaline bodies (HP:0003798)3.21677458
28Chronic bronchitis (HP:0004469)3.09070185
29Abnormality of skeletal muscle fiber size (HP:0012084)3.08302964
30Acute encephalopathy (HP:0006846)3.05365992
31Hepatocellular necrosis (HP:0001404)3.05355381
32Abnormal respiratory motile cilium physiology (HP:0012261)3.00217616
33Increased variability in muscle fiber diameter (HP:0003557)2.99384041
34Hepatic necrosis (HP:0002605)2.98130031
35Abnormal mitochondria in muscle tissue (HP:0008316)2.95180797
36Acute necrotizing encephalopathy (HP:0006965)2.93659810
37Abnormal respiratory motile cilium morphology (HP:0005938)2.83986499
38Abnormal respiratory epithelium morphology (HP:0012253)2.83986499
39Bulbar palsy (HP:0001283)2.82774791
40Hemorrhage of the eye (HP:0011885)2.82182564
41Rhinitis (HP:0012384)2.81200025
42Achilles tendon contracture (HP:0001771)2.79130329
43Cerebral edema (HP:0002181)2.78299695
44Hyperglycinemia (HP:0002154)2.76732840
45Poor suck (HP:0002033)2.75145744
46Mildly elevated creatine phosphokinase (HP:0008180)2.75067894
47Mitochondrial inheritance (HP:0001427)2.71822434
48Hyporeflexia of lower limbs (HP:0002600)2.70777937
49Difficulty climbing stairs (HP:0003551)2.67620830
50Lethargy (HP:0001254)2.66502917
51Malnutrition (HP:0004395)2.66328879
52Atonic seizures (HP:0010819)2.64680462
53Rhabdomyolysis (HP:0003201)2.64283944
54Abnormality of the Achilles tendon (HP:0005109)2.63102285
55Cholelithiasis (HP:0001081)2.62658030
56Pheochromocytoma (HP:0002666)2.62650847
57Spontaneous abortion (HP:0005268)2.59774501
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54931411
59Thin bony cortex (HP:0002753)2.54688919
60Abnormal gallbladder morphology (HP:0012437)2.52440106
61EMG: myopathic abnormalities (HP:0003458)2.52080352
62Muscle fiber splitting (HP:0003555)2.51637947
63Increased CSF lactate (HP:0002490)2.50934731
64Complement deficiency (HP:0004431)2.50791667
65Hyperglycinuria (HP:0003108)2.47900519
66Progressive macrocephaly (HP:0004481)2.46862434
67Abnormality of the intrinsic pathway (HP:0010989)2.46689996
68Ketosis (HP:0001946)2.45911130
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44785509
70Fat malabsorption (HP:0002630)2.44391605
71Vertebral compression fractures (HP:0002953)2.43753910
72Ventricular tachycardia (HP:0004756)2.42067818
73Neuroendocrine neoplasm (HP:0100634)2.41039045
74Hypolipoproteinemia (HP:0010981)2.38627180
75Hyperlipoproteinemia (HP:0010980)2.38485854
76Nasal polyposis (HP:0100582)2.38356680
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.36742360
78Hyperammonemia (HP:0001987)2.35994622
79Abnormality of methionine metabolism (HP:0010901)2.34438384
80Axonal loss (HP:0003447)2.33921255
81Protrusio acetabuli (HP:0003179)2.32222934
82Brushfield spots (HP:0001088)2.30120901
83Spinal rigidity (HP:0003306)2.30037436
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29305055
85Upper limb amyotrophy (HP:0009129)2.28588775
86Distal upper limb amyotrophy (HP:0007149)2.28588775
87Neck muscle weakness (HP:0000467)2.27127378
88Hyperbilirubinemia (HP:0002904)2.26514688
89Abnormality of glycine metabolism (HP:0010895)2.24390494
90Abnormality of serine family amino acid metabolism (HP:0010894)2.24390494
91Conjugated hyperbilirubinemia (HP:0002908)2.23200611
92Ulnar deviation of the wrist (HP:0003049)2.21902378
93Joint hemorrhage (HP:0005261)2.20454183
94Stridor (HP:0010307)2.19765724
95Ulnar bowing (HP:0003031)2.19602362
96Easy fatigability (HP:0003388)2.18829617
97Lower limb amyotrophy (HP:0007210)2.18094111
98Polyphagia (HP:0002591)2.17007688
99Abnormality of the common coagulation pathway (HP:0010990)2.16904099
100Muscle stiffness (HP:0003552)2.16012531
101Systemic lupus erythematosus (HP:0002725)2.15826985
102Lactic acidosis (HP:0003128)2.15603025
103Male infertility (HP:0003251)2.14174317
104CNS demyelination (HP:0007305)2.13575141
105Spastic tetraparesis (HP:0001285)2.13315056
106Abnormality of the gallbladder (HP:0005264)2.10394366
107Round ear (HP:0100830)2.09735753
108Abnormality of purine metabolism (HP:0004352)2.09371634
109Abnormality of serum amino acid levels (HP:0003112)2.09300446
110Abnormal atrioventricular conduction (HP:0005150)2.08538394
111Sudden death (HP:0001699)2.07799845
112Cerebral hemorrhage (HP:0001342)2.07558688
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05827013
114Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05827013
115Myoglobinuria (HP:0002913)2.05820414
116Abnormality of nucleobase metabolism (HP:0010932)2.05756300
117Premature rupture of membranes (HP:0001788)2.04606383
118Fragile skin (HP:0001030)2.04364031
119Ragged-red muscle fibers (HP:0003200)2.04226064
120Hypercortisolism (HP:0001578)2.03548677
121Hypercholesterolemia (HP:0003124)2.03038201
122Dysostosis multiplex (HP:0000943)2.02901941
123Abnormality of the nasal mucosa (HP:0000433)2.01314551
124Cerebral aneurysm (HP:0004944)1.99340597
125Eczematoid dermatitis (HP:0000976)1.98917512
126Abnormality of pyrimidine metabolism (HP:0004353)1.98525631
127Generalized amyotrophy (HP:0003700)1.98318047
128Abnormality of fatty-acid metabolism (HP:0004359)1.97394722
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96865146
130Hyperventilation (HP:0002883)1.96586900
131Oligomenorrhea (HP:0000876)1.95015696
132Conjunctival hamartoma (HP:0100780)1.94641570
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93638256
134Delusions (HP:0000746)1.92918329
135Bundle branch block (HP:0011710)1.92789236
136Difficulty running (HP:0009046)1.91560152
137Respiratory failure (HP:0002878)1.91489502
138Emotional lability (HP:0000712)1.90857778
139Medial flaring of the eyebrow (HP:0010747)1.90668246
140Decreased muscle mass (HP:0003199)1.90609784
141Vascular calcification (HP:0004934)1.90596314
142Irritability (HP:0000737)1.89772733
143Abnormality of the lower motor neuron (HP:0002366)1.88844880
144Abnormality of liposaccharide metabolism (HP:0010968)1.88544966
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.88544966
146Abnormality of glycolipid metabolism (HP:0010969)1.88544966
147Sensorimotor neuropathy (HP:0007141)1.88437510
148Steatorrhea (HP:0002570)1.88165874
149Abnormality of complement system (HP:0005339)1.87703300
150Hyperparathyroidism (HP:0000843)1.87357118
151Autoamputation (HP:0001218)1.86761503
152Obstructive sleep apnea (HP:0002870)1.86532087
153Foot dorsiflexor weakness (HP:0009027)1.86309124
154Cervical subluxation (HP:0003308)1.84096553
155Focal motor seizures (HP:0011153)1.83599465
156Abnormal spermatogenesis (HP:0008669)1.82821323
157Testicular atrophy (HP:0000029)1.82042987
158Atrioventricular block (HP:0001678)1.81495668
159Metabolic acidosis (HP:0001942)1.81163305
160Hypertriglyceridemia (HP:0002155)1.79957341
161Hypothermia (HP:0002045)1.79423459
162Increased serum ferritin (HP:0003281)1.78649783
163Polycythemia (HP:0001901)1.78523803
164Reticulocytosis (HP:0001923)1.78318320
165Cerebral inclusion bodies (HP:0100314)1.78311287
166Right ventricular cardiomyopathy (HP:0011663)1.77705665
167Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76651911
168Abnormality of polysaccharide metabolism (HP:0011012)1.76651911
169Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76651911
170Heart block (HP:0012722)1.76296098
171Cellulitis (HP:0100658)1.75879656
172Hyperacusis (HP:0010780)1.73819995
173Urinary glycosaminoglycan excretion (HP:0003541)1.72371003
174Mucopolysacchariduria (HP:0008155)1.72371003
175Joint stiffness (HP:0001387)1.71378560
176Broad face (HP:0000283)1.69200967
177Hypertensive crisis (HP:0100735)1.68827818
178Progressive muscle weakness (HP:0003323)1.68740732
179Abnormality of the foot musculature (HP:0001436)1.67411218
180Increased muscle lipid content (HP:0009058)1.63714686
181Atrophic scars (HP:0001075)1.63220625
182Rapidly progressive (HP:0003678)1.63016456
183Back pain (HP:0003418)1.61960308
184Purpura (HP:0000979)1.60077445
185Diaphragmatic weakness (HP:0009113)1.58702270
186Aneurysm (HP:0002617)1.58099977
187Neurofibrillary tangles (HP:0002185)1.56882548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.46867816
2PDK45.46867816
3TESK14.39501652
4TRIB34.19766025
5PDK23.23411508
6TTN2.96955266
7SIK12.91436966
8IRAK32.78452345
9BCKDK2.69704502
10EPHA22.61838629
11PRPF4B2.60733613
12SMG12.56094933
13PRKD32.49986654
14ICK2.19381216
15MAP3K122.19203433
16ARAF2.10406336
17BRAF2.09488577
18TSSK62.06751053
19MAPKAPK32.00825085
20ERBB41.99357504
21MAP2K31.95370617
22RIPK11.95198685
23LATS21.86766751
24CDK81.73644031
25TAOK21.71115044
26MST1R1.67204901
27NEK91.66237411
28MAP3K31.63745019
29STK38L1.57479777
30CCNB11.56939218
31WNK41.56031682
32TAOK31.52231812
33MAP2K71.50392178
34PTK2B1.49292370
35EEF2K1.46108479
36BUB11.43424268
37TESK21.39641012
38EPHB11.39389463
39OBSCN1.37766121
40MAP2K41.35062376
41NEK11.32447937
42AKT31.28568519
43MAP3K41.27931536
44ERN11.27844709
45KSR21.27573206
46EIF2AK31.25195720
47STK391.23521128
48MAP4K11.23060120
49LIMK11.18519988
50PIM21.14120820
51LMTK21.12307680
52PRKD21.10332525
53ABL21.09214594
54PRKCG1.09085521
55PTK61.07271099
56PKN21.06009775
57PAK41.05955565
58PNCK1.02693666
59MINK11.02178331
60PHKG11.01771279
61PHKG21.01771279
62NME11.00376331
63NTRK10.99613020
64IRAK20.98953861
65NEK20.96887676
66BRSK20.95192132
67IRAK40.94534949
68FGFR40.93673604
69MARK20.93638095
70MAPK120.92437383
71EIF2AK10.90109652
72RPS6KA20.89192485
73PTK20.88438296
74MAP3K100.85688398
75ZAP700.85685751
76MAP3K90.84018114
77CASK0.83333304
78STK380.82928074
79ACVR1B0.82391766
80SCYL20.81636648
81MAP2K20.81217526
82AURKA0.80158237
83MAP2K10.79907857
84MAP3K140.79263592
85NTRK30.79012773
86GRK50.78986620
87NME20.78296131
88RPS6KC10.77801576
89RPS6KL10.77801576
90DMPK0.77391657
91CDC42BPA0.77357523
92SIK30.76984562
93BMX0.76006223
94MAP3K110.74735084
95BLK0.74451296
96TAOK10.74359737
97MAPKAPK50.74327132
98DYRK20.73630881
99BRSK10.72606680
100MST40.72099155
101MAPK110.70583258
102PINK10.69137499
103MTOR0.68846790
104MUSK0.68514945
105DDR20.66367659
106STK160.66198549
107GRK60.66059927
108MAP3K60.65978570
109SIK20.65122878
110PDGFRA0.64144810
111MAP3K80.64011190
112DYRK1B0.63715641
113MOS0.62890486
114TBK10.61834401
115PRKG20.61251739
116DAPK10.60888059
117RIPK40.59313160
118CSK0.59005618
119MET0.57063505
120MAPK130.55964587
121LRRK20.55214423
122RPS6KA60.54849756
123KDR0.54551394
124MYLK0.54369271
125TYK20.53160635
126MAP3K10.52844629
127ILK0.48509697
128MAPK150.48404609
129PLK40.47917429
130TGFBR20.47410338
131MAP3K70.47209569
132HIPK20.46745389
133PDK10.46634034
134CDK140.46541943
135TNK20.45939708
136MAP2K60.45889869
137MAPK40.45229787
138PAK10.44579685
139INSRR0.44528276
140CDK120.44368907
141PRKD10.43754149
142RAF10.41690460
143PDPK10.41188115
144MAP3K130.40626802
145AKT20.40421184
146MATK0.40389287
147MARK30.40156000
148MAPK70.39680862
149CAMKK20.39298173
150PRKCZ0.38235551
151MAPKAPK20.37330813
152PLK10.37025796
153CDK180.35645788
154CAMK2G0.34153712
155CDK150.33135589
156PRKCI0.31568380
157PRKAA10.31456072
158EPHB20.29831471
159PLK20.29120413
160WNK30.28554246
161SGK2230.26956414
162SGK4940.26956414
163CAMKK10.26904862
164ADRBK10.26562888
165CAMK2A0.26249681
166SGK20.25830982

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.98889839
2Pyruvate metabolism_Homo sapiens_hsa006202.96629409
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91054326
4Other glycan degradation_Homo sapiens_hsa005112.89559548
5Vitamin B6 metabolism_Homo sapiens_hsa007502.58894117
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.56341350
7Arginine biosynthesis_Homo sapiens_hsa002202.26922382
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22767644
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22702957
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16985656
11Oxidative phosphorylation_Homo sapiens_hsa001902.13074814
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.08598323
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00306933
14Proteasome_Homo sapiens_hsa030501.99827893
15Tryptophan metabolism_Homo sapiens_hsa003801.94397374
16Collecting duct acid secretion_Homo sapiens_hsa049661.91105269
17Butanoate metabolism_Homo sapiens_hsa006501.89363293
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.86708454
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.81805262
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81722172
21Propanoate metabolism_Homo sapiens_hsa006401.80642014
22Carbon metabolism_Homo sapiens_hsa012001.79616226
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78918281
24Prion diseases_Homo sapiens_hsa050201.78666300
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71186728
26Bladder cancer_Homo sapiens_hsa052191.67357789
27Fatty acid degradation_Homo sapiens_hsa000711.64743352
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64679192
29Sulfur metabolism_Homo sapiens_hsa009201.63562635
30Acute myeloid leukemia_Homo sapiens_hsa052211.62484343
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61123171
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59954321
33Biosynthesis of amino acids_Homo sapiens_hsa012301.59497493
34Parkinsons disease_Homo sapiens_hsa050121.57373195
35Phenylalanine metabolism_Homo sapiens_hsa003601.55659075
36Peroxisome_Homo sapiens_hsa041461.55175289
37VEGF signaling pathway_Homo sapiens_hsa043701.54564713
38Complement and coagulation cascades_Homo sapiens_hsa046101.52732887
39Histidine metabolism_Homo sapiens_hsa003401.46148494
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46090784
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45211611
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45070749
43Selenocompound metabolism_Homo sapiens_hsa004501.44847426
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.44571110
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43720635
46Insulin signaling pathway_Homo sapiens_hsa049101.40779892
47Synaptic vesicle cycle_Homo sapiens_hsa047211.39966227
48Chemical carcinogenesis_Homo sapiens_hsa052041.37143813
49Notch signaling pathway_Homo sapiens_hsa043301.35634923
50Chronic myeloid leukemia_Homo sapiens_hsa052201.34106023
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30423161
52Fructose and mannose metabolism_Homo sapiens_hsa000511.30334829
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.29064673
54Tyrosine metabolism_Homo sapiens_hsa003501.26433740
55Fat digestion and absorption_Homo sapiens_hsa049751.25638872
56Huntingtons disease_Homo sapiens_hsa050161.24103511
57Pentose phosphate pathway_Homo sapiens_hsa000301.23184616
58Non-small cell lung cancer_Homo sapiens_hsa052231.20789570
59Dilated cardiomyopathy_Homo sapiens_hsa054141.19442047
60Fatty acid elongation_Homo sapiens_hsa000621.16813116
61Lysosome_Homo sapiens_hsa041421.15260651
62Insulin resistance_Homo sapiens_hsa049311.13873691
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.13357868
64Fatty acid metabolism_Homo sapiens_hsa012121.13165861
65Adipocytokine signaling pathway_Homo sapiens_hsa049201.12786728
66Osteoclast differentiation_Homo sapiens_hsa043801.10651141
67beta-Alanine metabolism_Homo sapiens_hsa004101.09269914
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07782247
69Alzheimers disease_Homo sapiens_hsa050101.07225806
70Vibrio cholerae infection_Homo sapiens_hsa051101.05976644
71Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05946291
72B cell receptor signaling pathway_Homo sapiens_hsa046621.05765244
73PPAR signaling pathway_Homo sapiens_hsa033201.04963639
74Nitrogen metabolism_Homo sapiens_hsa009101.04453015
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04091539
76Pancreatic cancer_Homo sapiens_hsa052121.03652020
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99415532
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99123692
79Arginine and proline metabolism_Homo sapiens_hsa003300.97691781
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97580208
81AMPK signaling pathway_Homo sapiens_hsa041520.97236212
82Retinol metabolism_Homo sapiens_hsa008300.96986529
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96479489
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95477782
85Glutathione metabolism_Homo sapiens_hsa004800.92351896
86Protein export_Homo sapiens_hsa030600.91621009
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.91390156
88Endocytosis_Homo sapiens_hsa041440.91117384
89Hepatitis C_Homo sapiens_hsa051600.90641598
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.89549381
91Bile secretion_Homo sapiens_hsa049760.87702676
92Amoebiasis_Homo sapiens_hsa051460.85802093
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.84617732
94Caffeine metabolism_Homo sapiens_hsa002320.83546697
95Focal adhesion_Homo sapiens_hsa045100.81748860
96mTOR signaling pathway_Homo sapiens_hsa041500.79387521
97Folate biosynthesis_Homo sapiens_hsa007900.79095192
98GnRH signaling pathway_Homo sapiens_hsa049120.78962796
99Endometrial cancer_Homo sapiens_hsa052130.78656016
100Metabolic pathways_Homo sapiens_hsa011000.78415999
101Regulation of autophagy_Homo sapiens_hsa041400.77604943
102Vitamin digestion and absorption_Homo sapiens_hsa049770.75715383
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74979474
104Thyroid cancer_Homo sapiens_hsa052160.74095378
105Salmonella infection_Homo sapiens_hsa051320.72951003
106Steroid biosynthesis_Homo sapiens_hsa001000.72852997
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72536949
108Glycerolipid metabolism_Homo sapiens_hsa005610.71167216
109Toxoplasmosis_Homo sapiens_hsa051450.70527379
110TNF signaling pathway_Homo sapiens_hsa046680.69579685
111Glioma_Homo sapiens_hsa052140.69167275
112Linoleic acid metabolism_Homo sapiens_hsa005910.68848214
113Apoptosis_Homo sapiens_hsa042100.68424787
114Renal cell carcinoma_Homo sapiens_hsa052110.68167757
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68097640
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67146218
117Pertussis_Homo sapiens_hsa051330.67064522
118Viral myocarditis_Homo sapiens_hsa054160.65087603
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64928479
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64904015
121Staphylococcus aureus infection_Homo sapiens_hsa051500.64546519
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64119673
123Leishmaniasis_Homo sapiens_hsa051400.63920854
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63624824
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63382955
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63105295
127Tuberculosis_Homo sapiens_hsa051520.63043327
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62606943
129Starch and sucrose metabolism_Homo sapiens_hsa005000.62064184
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61073507
131Shigellosis_Homo sapiens_hsa051310.60469155
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59655516
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57924578
134Sphingolipid metabolism_Homo sapiens_hsa006000.55770525
135Pyrimidine metabolism_Homo sapiens_hsa002400.53748419
136ErbB signaling pathway_Homo sapiens_hsa040120.53632599
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53269425
138Influenza A_Homo sapiens_hsa051640.53143528
139Sulfur relay system_Homo sapiens_hsa041220.52504709
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.52358197
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.51328560
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50705257
143ABC transporters_Homo sapiens_hsa020100.50225409
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49616853
145Malaria_Homo sapiens_hsa051440.47704025
146Hepatitis B_Homo sapiens_hsa051610.47504608
147Small cell lung cancer_Homo sapiens_hsa052220.47361702
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.46231961
149Proteoglycans in cancer_Homo sapiens_hsa052050.46150184
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.45894346
151Glucagon signaling pathway_Homo sapiens_hsa049220.45199915
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44195430
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41296765
154Inositol phosphate metabolism_Homo sapiens_hsa005620.40181462
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39324544
156Fatty acid biosynthesis_Homo sapiens_hsa000610.38067022
157Rheumatoid arthritis_Homo sapiens_hsa053230.34842139
158Phagosome_Homo sapiens_hsa041450.33923219
159Galactose metabolism_Homo sapiens_hsa000520.31740439
160Nicotine addiction_Homo sapiens_hsa050330.30230209
161Renin-angiotensin system_Homo sapiens_hsa046140.30071266
162Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26249132
163One carbon pool by folate_Homo sapiens_hsa006700.25181894
164Purine metabolism_Homo sapiens_hsa002300.22741804
165RNA polymerase_Homo sapiens_hsa030200.21475653
166Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19865865
167Cardiac muscle contraction_Homo sapiens_hsa042600.17976491

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