CPSF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.98342712
2DNA strand elongation involved in DNA replication (GO:0006271)4.69281197
3DNA replication initiation (GO:0006270)4.67255407
4DNA strand elongation (GO:0022616)4.43596926
5regulation of translational fidelity (GO:0006450)4.42523423
6protein localization to kinetochore (GO:0034501)4.38832949
7telomere maintenance via semi-conservative replication (GO:0032201)4.36248196
8DNA replication checkpoint (GO:0000076)4.32655828
9L-serine metabolic process (GO:0006563)4.29922606
10folic acid-containing compound biosynthetic process (GO:0009396)4.23151449
11protein localization to chromosome, centromeric region (GO:0071459)4.12587820
12ribosomal small subunit assembly (GO:0000028)4.10409658
13nuclear pore organization (GO:0006999)4.09339144
14DNA deamination (GO:0045006)3.98287157
15nucleobase biosynthetic process (GO:0046112)3.98112330
16DNA replication-dependent nucleosome assembly (GO:0006335)3.98004656
17DNA replication-dependent nucleosome organization (GO:0034723)3.98004656
18telomere maintenance via recombination (GO:0000722)3.92112777
19formation of translation preinitiation complex (GO:0001731)3.91876178
20mitotic metaphase plate congression (GO:0007080)3.91620090
21IMP biosynthetic process (GO:0006188)3.91281994
22ribosome biogenesis (GO:0042254)3.88738299
23mitotic nuclear envelope disassembly (GO:0007077)3.86187270
24maturation of SSU-rRNA (GO:0030490)3.85631209
25nuclear pore complex assembly (GO:0051292)3.83196264
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.80767763
27mitotic recombination (GO:0006312)3.76242722
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.74566868
29purine nucleobase biosynthetic process (GO:0009113)3.67504518
30proline biosynthetic process (GO:0006561)3.62050017
31mitotic sister chromatid segregation (GO:0000070)3.59943010
32CENP-A containing nucleosome assembly (GO:0034080)3.57802919
33chromatin remodeling at centromere (GO:0031055)3.56171058
34membrane disassembly (GO:0030397)3.55266662
35nuclear envelope disassembly (GO:0051081)3.55266662
36kinetochore organization (GO:0051383)3.53427104
37DNA strand renaturation (GO:0000733)3.50019576
38DNA topological change (GO:0006265)3.46904649
39DNA replication-independent nucleosome organization (GO:0034724)3.46346456
40DNA replication-independent nucleosome assembly (GO:0006336)3.46346456
41ribonucleoprotein complex biogenesis (GO:0022613)3.46216527
42peptidyl-arginine omega-N-methylation (GO:0035247)3.45547414
43telomere maintenance via telomere lengthening (GO:0010833)3.44606891
44dosage compensation (GO:0007549)3.43748510
45viral mRNA export from host cell nucleus (GO:0046784)3.43497974
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.42535229
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42535229
48histone arginine methylation (GO:0034969)3.40464702
49ribosome assembly (GO:0042255)3.39686607
50kinetochore assembly (GO:0051382)3.38364047
51IMP metabolic process (GO:0046040)3.37544171
52metaphase plate congression (GO:0051310)3.36875054
53pre-miRNA processing (GO:0031054)3.36719896
54protein-DNA complex disassembly (GO:0032986)3.36696833
55nucleosome disassembly (GO:0006337)3.36696833
56protein complex localization (GO:0031503)3.32591095
57sister chromatid segregation (GO:0000819)3.31234105
58pore complex assembly (GO:0046931)3.29358470
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.29329701
60DNA duplex unwinding (GO:0032508)3.28956091
61DNA geometric change (GO:0032392)3.28390047
62viral transcription (GO:0019083)3.26824853
63protein K6-linked ubiquitination (GO:0085020)3.26097839
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.23801257
65regulation of spindle organization (GO:0090224)3.23776304
66mitotic chromosome condensation (GO:0007076)3.22836563
67translational termination (GO:0006415)3.22122912
68regulation of gene silencing by RNA (GO:0060966)3.21904688
69regulation of posttranscriptional gene silencing (GO:0060147)3.21904688
70regulation of gene silencing by miRNA (GO:0060964)3.21904688
71negative regulation of histone methylation (GO:0031061)3.20962920
72negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18777954
73positive regulation of chromosome segregation (GO:0051984)3.16013886
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13547120
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.13123716
76translational initiation (GO:0006413)3.12718202
77protein complex disassembly (GO:0043241)3.12262875
78regulation of histone H3-K9 methylation (GO:0051570)3.11789373
79rRNA processing (GO:0006364)3.11786434
80ribosomal large subunit biogenesis (GO:0042273)3.11424518
81cellular protein complex disassembly (GO:0043624)3.11078337
82peptidyl-arginine methylation (GO:0018216)3.10086374
83peptidyl-arginine N-methylation (GO:0035246)3.10086374
84* viral life cycle (GO:0019058)3.09772828
85histone exchange (GO:0043486)3.09228418
86chromatin assembly or disassembly (GO:0006333)3.08053419
87translational elongation (GO:0006414)3.07505783
88protein localization to chromosome (GO:0034502)3.07210312
89spliceosomal snRNP assembly (GO:0000387)3.06977801
90establishment of chromosome localization (GO:0051303)3.06344877
91serine family amino acid biosynthetic process (GO:0009070)3.05127579
92mitotic sister chromatid cohesion (GO:0007064)3.04643514
93rRNA metabolic process (GO:0016072)3.02247359
94regulation of helicase activity (GO:0051095)3.01296467
95cellular protein complex localization (GO:0034629)3.00360354
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99963758
97folic acid metabolic process (GO:0046655)2.99530571
98chromatin assembly (GO:0031497)2.99040186
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97559848
100ribosomal small subunit biogenesis (GO:0042274)2.97418553
101regulation of telomere maintenance via telomerase (GO:0032210)2.97418009
102mismatch repair (GO:0006298)2.96104589
103ATP-dependent chromatin remodeling (GO:0043044)2.95344660
104attachment of spindle microtubules to kinetochore (GO:0008608)2.94617180
105regulation of double-strand break repair via homologous recombination (GO:0010569)2.94566604
106RNA splicing, via transesterification reactions (GO:0000375)2.93315888
107mRNA splicing, via spliceosome (GO:0000398)2.92550244
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.92550244
109cotranslational protein targeting to membrane (GO:0006613)2.91714939
110meiotic chromosome segregation (GO:0045132)2.91532184
111negative regulation of RNA splicing (GO:0033119)2.90452412
112GDP-mannose metabolic process (GO:0019673)2.90407074
113macromolecular complex disassembly (GO:0032984)2.88924744
114protein targeting to ER (GO:0045047)2.87805385
115termination of RNA polymerase II transcription (GO:0006369)2.86507198
116regulation of translational termination (GO:0006449)2.85221530
117regulation of mammary gland epithelial cell proliferation (GO:0033599)2.85167181
118base-excision repair (GO:0006284)2.85062789
119heterochromatin organization (GO:0070828)2.84798802
120regulation of mitotic spindle organization (GO:0060236)2.84598028
121DNA conformation change (GO:0071103)2.83832248
122negative regulation of mRNA metabolic process (GO:1903312)2.83105476
123translesion synthesis (GO:0019985)2.82744407
124regulation of mitochondrial translation (GO:0070129)2.82225393
125histone H4-K12 acetylation (GO:0043983)2.80156040
126transcription-coupled nucleotide-excision repair (GO:0006283)2.79268353
127establishment of integrated proviral latency (GO:0075713)2.79080685
128regulation of RNA export from nucleus (GO:0046831)2.77097532
129chromosome segregation (GO:0007059)2.76221189
130inner cell mass cell proliferation (GO:0001833)2.76201964
131establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76011673
132telomere maintenance (GO:0000723)2.75714845
133negative regulation of mRNA processing (GO:0050686)2.75579020
134telomere organization (GO:0032200)2.74711058
135chromosome condensation (GO:0030261)2.70476334
136homocysteine metabolic process (GO:0050667)2.66615938
137ncRNA 3-end processing (GO:0043628)2.65482028
138protein localization to endoplasmic reticulum (GO:0070972)2.65317860
139tRNA aminoacylation for protein translation (GO:0006418)2.65125425
140negative regulation of DNA-templated transcription, elongation (GO:0032785)2.64802427
141convergent extension (GO:0060026)2.64478364
142proline metabolic process (GO:0006560)2.63110172
143negative regulation of telomerase activity (GO:0051974)2.62830070
144amino acid activation (GO:0043038)2.62345174
145tRNA aminoacylation (GO:0043039)2.62345174
146positive regulation of DNA-dependent DNA replication (GO:2000105)2.61669439
147rRNA transcription (GO:0009303)2.61314462
148nuclear envelope organization (GO:0006998)2.61245871
149DNA damage induced protein phosphorylation (GO:0006975)2.60477724
150base-excision repair, AP site formation (GO:0006285)2.60135179
151nuclear-transcribed mRNA catabolic process (GO:0000956)2.57075123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.75520644
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.25318151
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.93907310
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45808733
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41564167
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09544806
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88540515
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63203101
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57182308
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.42410711
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.34461354
12MYC_22102868_ChIP-Seq_BL_Human2.30780766
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29723764
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.26885034
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25185956
16XRN2_22483619_ChIP-Seq_HELA_Human2.21316772
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17642956
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09770773
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07955860
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05072185
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.04522478
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.02685466
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96461482
24AR_21909140_ChIP-Seq_LNCAP_Human1.87691122
25VDR_23849224_ChIP-Seq_CD4+_Human1.85990509
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82639054
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82138540
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79445663
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78088387
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.74397213
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72656275
32GABP_19822575_ChIP-Seq_HepG2_Human1.71464854
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70556354
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69201015
35DCP1A_22483619_ChIP-Seq_HELA_Human1.67996341
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.67784142
37CIITA_25753668_ChIP-Seq_RAJI_Human1.67690596
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62764186
39TTF2_22483619_ChIP-Seq_HELA_Human1.61080136
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60659628
41LXR_22292898_ChIP-Seq_THP-1_Human1.59936169
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56172714
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55776214
44KDM5A_27292631_Chip-Seq_BREAST_Human1.54715414
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51971110
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50610096
47ZNF263_19887448_ChIP-Seq_K562_Human1.49905805
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44882949
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44716849
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43426190
51VDR_21846776_ChIP-Seq_THP-1_Human1.43083817
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39222792
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38844335
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.38371125
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36036123
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34195156
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33217986
58P68_20966046_ChIP-Seq_HELA_Human1.33030172
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32747961
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.31731270
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31109694
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.30153782
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28114520
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26979585
65RACK7_27058665_Chip-Seq_MCF-7_Human1.26513172
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26370269
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25118639
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.25061706
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23789224
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23551488
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22504152
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22008653
73* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21923506
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21403733
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.20529957
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20397631
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19593551
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18672653
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17382746
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16931074
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16304391
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.15017737
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13415804
84NCOR1_26117541_ChIP-Seq_K562_Human1.11080926
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10436994
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10433643
87ELK1_19687146_ChIP-ChIP_HELA_Human1.09674604
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08752605
89TFEB_21752829_ChIP-Seq_HELA_Human1.08478238
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08109609
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07789460
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07326488
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07278920
94KDM2B_26808549_Chip-Seq_DND41_Human1.05608407
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05555768
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04529816
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04241682
98MAF_26560356_Chip-Seq_TH2_Human1.03411930
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03376919
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.03082702
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.02496278
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02316710
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01209897
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00533646
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99938956
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99938956
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99938956
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99673899
109CREB1_26743006_Chip-Seq_LNCaP_Human0.98596529
110TCF7_22412390_ChIP-Seq_EML_Mouse0.96840875
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96484163
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95199177
113* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95123624
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.94143254
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93522608
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93507355
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93457484
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.93273280
119KDM2B_26808549_Chip-Seq_K562_Human0.93023885
120CTCF_21964334_Chip-Seq_Bcells_Human0.92674869
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92396281
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92316397
123* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91642381
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89754520
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89596165
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89407014
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.87562521
128SPI1_23547873_ChIP-Seq_NB4_Human0.85098394
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84794992
130UTX_26944678_Chip-Seq_JUKART_Human0.84317721
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81069937
132MYC_18940864_ChIP-ChIP_HL60_Human0.79906274
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78546071
134POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77969849
135* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77583093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.29846202
2MP0003111_abnormal_nucleus_morphology4.42406816
3MP0010094_abnormal_chromosome_stability4.29467018
4MP0004957_abnormal_blastocyst_morpholog4.03304456
5MP0003077_abnormal_cell_cycle3.85643559
6MP0008057_abnormal_DNA_replication3.83301867
7MP0008058_abnormal_DNA_repair3.14237360
8MP0003136_yellow_coat_color3.02518966
9MP0008007_abnormal_cellular_replicative2.74786834
10MP0001730_embryonic_growth_arrest2.54075117
11MP0003123_paternal_imprinting2.37074573
12MP0000350_abnormal_cell_proliferation2.35606635
13MP0010352_gastrointestinal_tract_polyps2.33000707
14MP0008932_abnormal_embryonic_tissue2.26478473
15MP0002396_abnormal_hematopoietic_system2.23010278
16MP0008877_abnormal_DNA_methylation2.19264960
17MP0010307_abnormal_tumor_latency2.11589031
18MP0005171_absent_coat_pigmentation2.06909332
19MP0005380_embryogenesis_phenotype1.94842682
20MP0001672_abnormal_embryogenesis/_devel1.94842682
21MP0003806_abnormal_nucleotide_metabolis1.94590182
22MP0001188_hyperpigmentation1.87856670
23MP0003786_premature_aging1.84544130
24MP0005423_abnormal_somatic_nervous1.83684760
25MP0001697_abnormal_embryo_size1.74481662
26MP0009379_abnormal_foot_pigmentation1.71608533
27MP0004233_abnormal_muscle_weight1.70905694
28MP0003984_embryonic_growth_retardation1.70253949
29MP0002088_abnormal_embryonic_growth/wei1.67381785
30MP0000490_abnormal_crypts_of1.66729108
31MP0004185_abnormal_adipocyte_glucose1.65755398
32MP0009333_abnormal_splenocyte_physiolog1.63673864
33MP0002085_abnormal_embryonic_tissue1.62966270
34MP0002080_prenatal_lethality1.62072113
35MP0000313_abnormal_cell_death1.60863936
36MP0002086_abnormal_extraembryonic_tissu1.59059692
37MP0004808_abnormal_hematopoietic_stem1.58297280
38MP0002254_reproductive_system_inflammat1.57212239
39MP0002089_abnormal_postnatal_growth/wei1.52892376
40MP0003121_genomic_imprinting1.52479935
41MP0004197_abnormal_fetal_growth/weight/1.51315478
42MP0002084_abnormal_developmental_patter1.49905676
43MP0002019_abnormal_tumor_incidence1.48700385
44MP0001346_abnormal_lacrimal_gland1.43832116
45MP0003718_maternal_effect1.38836990
46MP0003763_abnormal_thymus_physiology1.36536676
47MP0001545_abnormal_hematopoietic_system1.32881970
48MP0005397_hematopoietic_system_phenotyp1.32881970
49MP0002398_abnormal_bone_marrow1.31116962
50MP0001293_anophthalmia1.30278307
51MP0005076_abnormal_cell_differentiation1.29717264
52MP0010030_abnormal_orbit_morphology1.29310687
53MP0003890_abnormal_embryonic-extraembry1.27828511
54MP0000703_abnormal_thymus_morphology1.26269673
55MP0003705_abnormal_hypodermis_morpholog1.26037892
56MP0002249_abnormal_larynx_morphology1.23971923
57MP0005501_abnormal_skin_physiology1.23493424
58MP0005083_abnormal_biliary_tract1.21994346
59MP0005174_abnormal_tail_pigmentation1.21048066
60MP0002210_abnormal_sex_determination1.20668586
61MP0003567_abnormal_fetal_cardiomyocyte1.20628889
62MP0002722_abnormal_immune_system1.17855905
63MP0005451_abnormal_body_composition1.17503147
64MP0009053_abnormal_anal_canal1.17467919
65MP0000689_abnormal_spleen_morphology1.16397082
66MP0002697_abnormal_eye_size1.15982678
67MP0002653_abnormal_ependyma_morphology1.13992253
68MP0008260_abnormal_autophagy1.12223621
69MP0003861_abnormal_nervous_system1.10881877
70MP0003315_abnormal_perineum_morphology1.09157275
71MP0006292_abnormal_olfactory_placode1.08429793
72MP0000858_altered_metastatic_potential1.05649470
73MP0009278_abnormal_bone_marrow1.04346320
74MP0003119_abnormal_digestive_system1.03028505
75MP0001145_abnormal_male_reproductive1.02154613
76MP0009672_abnormal_birth_weight1.01476063
77MP0003186_abnormal_redox_activity1.00142501
78MP0002877_abnormal_melanocyte_morpholog0.99096833
79MP0003878_abnormal_ear_physiology0.98791459
80MP0005377_hearing/vestibular/ear_phenot0.98791459
81MP0002429_abnormal_blood_cell0.98357795
82MP0000566_synostosis0.97789008
83MP0000015_abnormal_ear_pigmentation0.95699804
84MP0005058_abnormal_lysosome_morphology0.95609572
85MP0001119_abnormal_female_reproductive0.95237177
86MP0001929_abnormal_gametogenesis0.93492779
87MP0004133_heterotaxia0.93455591
88MP0003385_abnormal_body_wall0.93140358
89MP0001915_intracranial_hemorrhage0.92244565
90MP0002160_abnormal_reproductive_system0.91803755
91MP0002132_abnormal_respiratory_system0.90583478
92MP0006035_abnormal_mitochondrial_morpho0.90444495
93MP0000653_abnormal_sex_gland0.90261539
94MP0001299_abnormal_eye_distance/0.89349094
95MP0000428_abnormal_craniofacial_morphol0.88749390
96MP0001661_extended_life_span0.86320231
97MP0000716_abnormal_immune_system0.84552852
98MP0001849_ear_inflammation0.83171262
99MP0003942_abnormal_urinary_system0.82525636
100MP0001986_abnormal_taste_sensitivity0.81729802
101MP0003937_abnormal_limbs/digits/tail_de0.81461220
102MP0000358_abnormal_cell_content/0.80660596
103MP0004147_increased_porphyrin_level0.79806214
104MP0002111_abnormal_tail_morphology0.79762376
105MP0001286_abnormal_eye_development0.79517013
106MP0000750_abnormal_muscle_regeneration0.78291579
107MP0005023_abnormal_wound_healing0.78173605
108MP0001800_abnormal_humoral_immune0.77519124
109MP0003935_abnormal_craniofacial_develop0.77488985
110MP0000462_abnormal_digestive_system0.76099593
111MP0003115_abnormal_respiratory_system0.75602721
112MP0005384_cellular_phenotype0.75012740
113MP0008789_abnormal_olfactory_epithelium0.73471139
114MP0002938_white_spotting0.73267148
115MP0000003_abnormal_adipose_tissue0.73075040
116MP0002405_respiratory_system_inflammati0.72947574
117MP0002075_abnormal_coat/hair_pigmentati0.71867762
118MP0003938_abnormal_ear_development0.71708561
119MP0001502_abnormal_circadian_rhythm0.71043861
120MP0004264_abnormal_extraembryonic_tissu0.70402735
121MP0002751_abnormal_autonomic_nervous0.69856248
122MP0005389_reproductive_system_phenotype0.69425987
123MP0000477_abnormal_intestine_morphology0.69412465
124MP0002269_muscular_atrophy0.68715603
125MP0003453_abnormal_keratinocyte_physiol0.68581817
126MP0009703_decreased_birth_body0.68343860
127MP0008770_decreased_survivor_rate0.68233165
128MP0002092_abnormal_eye_morphology0.68129389
129MP0000467_abnormal_esophagus_morphology0.67661772
130MP0002796_impaired_skin_barrier0.66497914
131MP0005621_abnormal_cell_physiology0.66223214
132MP0003787_abnormal_imprinting0.65153544
133MP0002420_abnormal_adaptive_immunity0.64432280
134MP0008995_early_reproductive_senescence0.64235109
135MP0000371_diluted_coat_color0.63623225
136MP0001819_abnormal_immune_cell0.63463052
137MP0005394_taste/olfaction_phenotype0.63424643
138MP0005499_abnormal_olfactory_system0.63424643
139MP0000537_abnormal_urethra_morphology0.63405509
140MP0000598_abnormal_liver_morphology0.62867344
141MP0003436_decreased_susceptibility_to0.62374406
142MP0003699_abnormal_female_reproductive0.62106268
143MP0003448_altered_tumor_morphology0.61526712
144MP0002452_abnormal_antigen_presenting0.61110208
145MP0001835_abnormal_antigen_presentation0.60189551
146MP0009840_abnormal_foam_cell0.59186133
147MP0000685_abnormal_immune_system0.58226889
148MP0003221_abnormal_cardiomyocyte_apopto0.58063800

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.02019487
2Abnormality of the anterior horn cell (HP:0006802)4.14434506
3Degeneration of anterior horn cells (HP:0002398)4.14434506
4Ependymoma (HP:0002888)3.81163320
5Breast hypoplasia (HP:0003187)3.75508538
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75309271
7Reticulocytopenia (HP:0001896)3.73486550
8Patellar aplasia (HP:0006443)3.68772195
9Chromsome breakage (HP:0040012)3.60347224
10Oral leukoplakia (HP:0002745)3.51771811
11Abnormality of cells of the erythroid lineage (HP:0012130)3.49403015
12Aplasia/Hypoplasia of the patella (HP:0006498)3.45978176
13Abnormal number of erythroid precursors (HP:0012131)3.36233973
14Selective tooth agenesis (HP:0001592)3.29056900
15Agnosia (HP:0010524)3.26636643
16Medulloblastoma (HP:0002885)3.24872630
17High anterior hairline (HP:0009890)3.18727319
18Impulsivity (HP:0100710)3.04478883
19Meckel diverticulum (HP:0002245)2.95655248
20Multiple enchondromatosis (HP:0005701)2.93096656
21Abnormal number of incisors (HP:0011064)2.91226455
22Turricephaly (HP:0000262)2.88794709
23Abnormality of the ileum (HP:0001549)2.86806918
24Absent thumb (HP:0009777)2.85569104
25Rhabdomyosarcoma (HP:0002859)2.83439194
26Abnormality of chromosome stability (HP:0003220)2.81199472
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.80756936
28Microvesicular hepatic steatosis (HP:0001414)2.78165228
29Abnormality of the preputium (HP:0100587)2.76429140
30Carpal bone hypoplasia (HP:0001498)2.75642374
31Abnormality of pyrimidine metabolism (HP:0004353)2.74175183
32Basal cell carcinoma (HP:0002671)2.70769550
33Myelodysplasia (HP:0002863)2.69791602
34Ulnar bowing (HP:0003031)2.65214303
35Colon cancer (HP:0003003)2.64710282
36Squamous cell carcinoma (HP:0002860)2.63524781
37Rib fusion (HP:0000902)2.56216379
38Progressive muscle weakness (HP:0003323)2.55861414
39Progressive external ophthalmoplegia (HP:0000590)2.54819260
40Insomnia (HP:0100785)2.54503467
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.50996441
42Broad distal phalanx of finger (HP:0009836)2.48913799
43Aplastic anemia (HP:0001915)2.42109488
44Abnormality of the astrocytes (HP:0100707)2.40766745
45Astrocytoma (HP:0009592)2.40766745
46Absent radius (HP:0003974)2.39919157
47Ectopic kidney (HP:0000086)2.39248163
48Tracheoesophageal fistula (HP:0002575)2.38399147
49Duodenal stenosis (HP:0100867)2.33201224
50Small intestinal stenosis (HP:0012848)2.33201224
51Trismus (HP:0000211)2.32155058
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31988699
53Abnormality of the labia minora (HP:0012880)2.30677883
54Neoplasm of the pancreas (HP:0002894)2.30248978
55Macrocytic anemia (HP:0001972)2.30235882
56Prominent nose (HP:0000448)2.28198147
57Coronal craniosynostosis (HP:0004440)2.27773035
58Bone marrow hypocellularity (HP:0005528)2.27469586
59Myopathic facies (HP:0002058)2.27183330
60Rough bone trabeculation (HP:0100670)2.25989340
61Neoplasm of striated muscle (HP:0009728)2.25710267
62Reticulocytosis (HP:0001923)2.23957883
6311 pairs of ribs (HP:0000878)2.23621651
64Atresia of the external auditory canal (HP:0000413)2.22743773
65Microretrognathia (HP:0000308)2.22410355
66Premature ovarian failure (HP:0008209)2.22027569
67Deep palmar crease (HP:0006191)2.21894086
68Pallor (HP:0000980)2.20619709
69Duplication of thumb phalanx (HP:0009942)2.20557521
70Facial hemangioma (HP:0000329)2.20358595
71Overriding aorta (HP:0002623)2.19994820
72Aplasia involving forearm bones (HP:0009822)2.18646073
73Absent forearm bone (HP:0003953)2.18646073
74Cortical dysplasia (HP:0002539)2.18141942
75Abnormality of reticulocytes (HP:0004312)2.13348345
76Pseudobulbar signs (HP:0002200)2.12822520
77Thrombocytosis (HP:0001894)2.11470768
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11139324
79Cellular immunodeficiency (HP:0005374)2.10702382
80Choanal stenosis (HP:0000452)2.10231460
81Cafe-au-lait spot (HP:0000957)2.08431107
82Cleft eyelid (HP:0000625)2.08331502
83Horseshoe kidney (HP:0000085)2.08116476
84Abnormality of the carotid arteries (HP:0005344)2.08107342
85Glioma (HP:0009733)2.08091833
86Poikiloderma (HP:0001029)2.07679112
87Supernumerary spleens (HP:0009799)2.07578742
88Sloping forehead (HP:0000340)2.07295785
89Truncus arteriosus (HP:0001660)2.07040925
90Long palpebral fissure (HP:0000637)2.04205446
91Abnormal lung lobation (HP:0002101)2.03397264
92Tongue fasciculations (HP:0001308)2.03198559
93Proximal placement of thumb (HP:0009623)2.03098540
94Abnormality of DNA repair (HP:0003254)2.02068294
95Cholecystitis (HP:0001082)2.01924586
96Abnormal gallbladder physiology (HP:0012438)2.01924586
97Intestinal fistula (HP:0100819)2.00849742
98Deviation of the thumb (HP:0009603)2.00832049
99Increased nuchal translucency (HP:0010880)2.00185146
100Missing ribs (HP:0000921)1.99831056
101Rectal fistula (HP:0100590)1.99386676
102Rectovaginal fistula (HP:0000143)1.99386676
103Homocystinuria (HP:0002156)1.98405954
104Abnormality of homocysteine metabolism (HP:0010919)1.98405954
105Cerebral hypomyelination (HP:0006808)1.97511844
106Amaurosis fugax (HP:0100576)1.97423645
107Abnormality of the duodenum (HP:0002246)1.97287015
108Annular pancreas (HP:0001734)1.96315622
109Premature graying of hair (HP:0002216)1.94638214
110Thin ribs (HP:0000883)1.94050520
111Dysphonia (HP:0001618)1.93597551
112High pitched voice (HP:0001620)1.91938152
113Stridor (HP:0010307)1.90781376
114Abnormality of the motor neurons (HP:0002450)1.87703813
115Abnormal neuron morphology (HP:0012757)1.87703813
116Abnormality of abdominal situs (HP:0011620)1.87626097
117Abdominal situs inversus (HP:0003363)1.87626097
118Triphalangeal thumb (HP:0001199)1.86967616
119Partial duplication of thumb phalanx (HP:0009944)1.86877597
120Hyperacusis (HP:0010780)1.86817623
121Diaphragmatic weakness (HP:0009113)1.85415363
122Testicular atrophy (HP:0000029)1.84653907
123Preauricular skin tag (HP:0000384)1.83161062
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82808268
125Elfin facies (HP:0004428)1.82109119
126Cutaneous melanoma (HP:0012056)1.81409029
127Lymphoma (HP:0002665)1.80888542
128Upper limb amyotrophy (HP:0009129)1.79160110
129Distal upper limb amyotrophy (HP:0007149)1.79160110
130Clubbing of toes (HP:0100760)1.78975634
131Slender long bone (HP:0003100)1.78351647
132Short thumb (HP:0009778)1.77872652
133Absent epiphyses (HP:0010577)1.77577057
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77577057
135Overlapping toe (HP:0001845)1.77319958
136Skin tags (HP:0010609)1.77199299
137Neoplasm of the oral cavity (HP:0100649)1.77014624
138Vaginal fistula (HP:0004320)1.75862704
139Hand muscle atrophy (HP:0009130)1.73949538
140Spina bifida occulta (HP:0003298)1.73524811
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71595917
142Ragged-red muscle fibers (HP:0003200)1.69396904
143External ophthalmoplegia (HP:0000544)1.64536182
144Renal duplication (HP:0000075)1.64259001
145Spastic diplegia (HP:0001264)1.62208844
146Achilles tendon contracture (HP:0001771)1.62194432
147Pterygium (HP:0001059)1.61914426
148Partial duplication of the phalanx of hand (HP:0009999)1.61219150
149Cholelithiasis (HP:0001081)1.60848010
150Bilateral microphthalmos (HP:0007633)1.60311500
151Generalized hypotonia (HP:0001290)1.59876663
152Pointed chin (HP:0000307)1.58609239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.31892474
2SMG13.91064192
3BUB13.67269960
4WEE13.61210480
5NEK23.00153304
6CDK122.87382027
7VRK22.61619966
8SRPK12.43857190
9MAP3K102.25836853
10TTK2.22574946
11EIF2AK12.22358814
12EEF2K2.01481178
13PLK11.96206132
14NME21.87214062
15CDK41.84988880
16CDK71.83750515
17SIK11.72893114
18IRAK21.71366748
19EPHA21.67292034
20DYRK31.65617081
21TSSK61.65199028
22ATR1.63356558
23PBK1.61355719
24PLK41.59445259
25CHEK21.56928477
26RPS6KA41.52836393
27TAF11.52747125
28TLK11.51413314
29PRPF4B1.49554703
30VRK11.49327473
31BRSK21.48987931
32NME11.48966170
33AURKB1.47505190
34IRAK31.46943713
35NEK11.45826109
36PIM11.44174632
37STK101.42623923
38PASK1.41765627
39ACVR1B1.41397096
40MKNK11.39921024
41RPS6KB21.38663329
42PLK31.37075367
43STK41.36062764
44MAP3K81.35904901
45TYRO31.35368259
46MAP4K11.31361452
47CHEK11.30702009
48AURKA1.29296113
49MUSK1.27062476
50MAP2K31.26784244
51PAK41.21040750
52TESK21.17951399
53PIM21.17320658
54GRK61.15667426
55PRKD31.15322345
56SCYL21.14966313
57PKN21.11640232
58BRSK11.08988468
59BMX1.08491627
60CAMK1D1.07213174
61MAP3K111.02912791
62MAP3K91.02679055
63SIK21.00771467
64TAOK20.96957512
65BRD40.95938774
66CDK20.95537481
67DYRK20.91403048
68ALK0.91270643
69CDK60.91006537
70MKNK20.90598916
71LMTK20.89526653
72KSR20.89158766
73EIF2AK30.88470533
74BRAF0.88226976
75ATM0.86257520
76PDK20.82912983
77FLT30.81558605
78ICK0.76356861
79ZAK0.75822510
80CDK80.72882181
81MAP3K30.72310448
82ZAP700.71940552
83LATS20.71880736
84TYK20.71679973
85MELK0.71510030
86STK30.71493429
87CDK11A0.70576846
88CAMK1G0.70341618
89RPS6KA20.65480729
90CDK150.65078144
91TRIB30.64937425
92LRRK20.61953205
93PAK10.61447761
94AKT20.60251001
95CCNB10.60045671
96TGFBR10.59981761
97CDK10.59721530
98CSNK2A20.58419605
99MTOR0.57586665
100CDK180.56143571
101FGFR40.55904195
102MAPK110.54473162
103CSNK2A10.54253026
104JAK30.51834084
105CSF1R0.48353966
106RPS6KA50.47435861
107PTK60.47117974
108KDR0.46910239
109STK160.46640692
110DAPK10.46247877
111TAOK10.45552891
112BTK0.44846994
113ARAF0.44667525
114TTN0.43953282
115MAP2K20.43464388
116ERBB40.43066975
117CLK10.42397838
118RPS6KC10.42357132
119RPS6KL10.42357132
120WNK40.42291561
121GSK3B0.42251243
122CDK140.41666012
123ERBB30.41270552
124LATS10.41148639
125RPS6KA10.39706236
126RPS6KA60.39101480
127PRKCI0.38393118
128BLK0.37017643
129MAPK140.36586610
130STK38L0.36536668
131IKBKB0.36242565
132CHUK0.35252229
133CSNK1E0.34426248
134RAF10.33944399
135EIF2AK20.33453002
136BCKDK0.33071466

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08429807
2Mismatch repair_Homo sapiens_hsa034304.46724707
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.70364514
4Spliceosome_Homo sapiens_hsa030403.35635956
5One carbon pool by folate_Homo sapiens_hsa006703.23594634
6Base excision repair_Homo sapiens_hsa034103.15894475
7RNA transport_Homo sapiens_hsa030133.07603085
8Ribosome_Homo sapiens_hsa030102.93407675
9RNA polymerase_Homo sapiens_hsa030202.90269198
10Nucleotide excision repair_Homo sapiens_hsa034202.73173383
11Homologous recombination_Homo sapiens_hsa034402.68602515
12Cell cycle_Homo sapiens_hsa041102.62624525
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38756938
14Proteasome_Homo sapiens_hsa030502.37295504
15Pyrimidine metabolism_Homo sapiens_hsa002402.35528606
16Fanconi anemia pathway_Homo sapiens_hsa034602.20700016
17* mRNA surveillance pathway_Homo sapiens_hsa030151.92186399
18Basal transcription factors_Homo sapiens_hsa030221.77416922
19RNA degradation_Homo sapiens_hsa030181.75774978
20Fructose and mannose metabolism_Homo sapiens_hsa000511.63369731
21p53 signaling pathway_Homo sapiens_hsa041151.56343635
22Non-homologous end-joining_Homo sapiens_hsa034501.53446400
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37606813
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.34022049
25Systemic lupus erythematosus_Homo sapiens_hsa053221.30866836
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.25599738
27Epstein-Barr virus infection_Homo sapiens_hsa051691.17893431
28Herpes simplex infection_Homo sapiens_hsa051681.11228056
29Selenocompound metabolism_Homo sapiens_hsa004501.09876730
30Viral carcinogenesis_Homo sapiens_hsa052031.06308343
31Pyruvate metabolism_Homo sapiens_hsa006201.03604797
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03422923
33Purine metabolism_Homo sapiens_hsa002301.03143503
34Biosynthesis of amino acids_Homo sapiens_hsa012301.02559141
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99404146
36Pentose phosphate pathway_Homo sapiens_hsa000300.96273778
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.95933616
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93633573
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.92985122
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89455226
41HTLV-I infection_Homo sapiens_hsa051660.86441065
42Folate biosynthesis_Homo sapiens_hsa007900.85735422
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84413924
44Vitamin B6 metabolism_Homo sapiens_hsa007500.82866177
45N-Glycan biosynthesis_Homo sapiens_hsa005100.79451945
46Sulfur relay system_Homo sapiens_hsa041220.78601507
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78025716
48Hedgehog signaling pathway_Homo sapiens_hsa043400.77848691
49Antigen processing and presentation_Homo sapiens_hsa046120.77172425
50Oocyte meiosis_Homo sapiens_hsa041140.73837928
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69746859
52MicroRNAs in cancer_Homo sapiens_hsa052060.69443533
53Notch signaling pathway_Homo sapiens_hsa043300.68677240
54Primary immunodeficiency_Homo sapiens_hsa053400.67178503
55Small cell lung cancer_Homo sapiens_hsa052220.67095097
56Apoptosis_Homo sapiens_hsa042100.65954514
57Chronic myeloid leukemia_Homo sapiens_hsa052200.65932844
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63900321
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63893866
60Thyroid cancer_Homo sapiens_hsa052160.62270735
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62034115
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60967035
63Colorectal cancer_Homo sapiens_hsa052100.60439837
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58263251
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57680809
66Acute myeloid leukemia_Homo sapiens_hsa052210.57658120
67Huntingtons disease_Homo sapiens_hsa050160.56704797
68Insulin signaling pathway_Homo sapiens_hsa049100.56470841
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55578028
70Measles_Homo sapiens_hsa051620.54451554
71Lysine degradation_Homo sapiens_hsa003100.52700179
72Prostate cancer_Homo sapiens_hsa052150.52267261
73ErbB signaling pathway_Homo sapiens_hsa040120.52258344
74Legionellosis_Homo sapiens_hsa051340.51841469
75Other glycan degradation_Homo sapiens_hsa005110.51107798
76Wnt signaling pathway_Homo sapiens_hsa043100.49090148
77Shigellosis_Homo sapiens_hsa051310.47994430
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.47878839
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47868977
80Glioma_Homo sapiens_hsa052140.47406587
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47057822
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46894261
83AMPK signaling pathway_Homo sapiens_hsa041520.46315629
84Bladder cancer_Homo sapiens_hsa052190.45099940
85Hepatitis B_Homo sapiens_hsa051610.44781985
86VEGF signaling pathway_Homo sapiens_hsa043700.43615356
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43486699
88Parkinsons disease_Homo sapiens_hsa050120.42134864
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41546407
90Carbon metabolism_Homo sapiens_hsa012000.41481344
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41242426
92Non-small cell lung cancer_Homo sapiens_hsa052230.40411755
93Inositol phosphate metabolism_Homo sapiens_hsa005620.37586908
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36551609
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36551456
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35446315
97Glutathione metabolism_Homo sapiens_hsa004800.35249965
98Alcoholism_Homo sapiens_hsa050340.35145001
99Basal cell carcinoma_Homo sapiens_hsa052170.34933909
100Melanoma_Homo sapiens_hsa052180.34413833
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.34131850
102mTOR signaling pathway_Homo sapiens_hsa041500.33631480
103* Influenza A_Homo sapiens_hsa051640.32491204
104Hippo signaling pathway_Homo sapiens_hsa043900.31205748
105Metabolic pathways_Homo sapiens_hsa011000.30948204
106Pancreatic cancer_Homo sapiens_hsa052120.30462871
107Melanogenesis_Homo sapiens_hsa049160.30406261
108Steroid biosynthesis_Homo sapiens_hsa001000.29903561
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28668924
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27304765
111Viral myocarditis_Homo sapiens_hsa054160.26389349
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25931344
113B cell receptor signaling pathway_Homo sapiens_hsa046620.24890191
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24382356
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24349182
116TGF-beta signaling pathway_Homo sapiens_hsa043500.22648114
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21771956
118Galactose metabolism_Homo sapiens_hsa000520.21317260
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20725924
120Endometrial cancer_Homo sapiens_hsa052130.20449787
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19259711
122Pathways in cancer_Homo sapiens_hsa052000.19224294
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.18975620
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16971999
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15961676
126Leishmaniasis_Homo sapiens_hsa051400.15237057
127Hematopoietic cell lineage_Homo sapiens_hsa046400.15068367
128HIF-1 signaling pathway_Homo sapiens_hsa040660.15067192
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.13416813
130Arginine and proline metabolism_Homo sapiens_hsa003300.12800138
131Adherens junction_Homo sapiens_hsa045200.12071088

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