CPSF3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)5.34518512
2DNA strand elongation involved in DNA replication (GO:0006271)5.15872253
3mannose metabolic process (GO:0006013)5.02086790
4ribosomal small subunit assembly (GO:0000028)4.97897358
5telomere maintenance via semi-conservative replication (GO:0032201)4.92933271
6DNA strand elongation (GO:0022616)4.90945491
7DNA deamination (GO:0045006)4.82940241
8maturation of SSU-rRNA (GO:0030490)4.77567729
9DNA replication initiation (GO:0006270)4.69564653
10nucleobase biosynthetic process (GO:0046112)4.54395631
11negative regulation of erythrocyte differentiation (GO:0045647)4.51384267
12DNA unwinding involved in DNA replication (GO:0006268)4.48017760
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.39925213
14telomere maintenance via recombination (GO:0000722)4.31840673
15formation of translation preinitiation complex (GO:0001731)4.30191222
16purine nucleobase biosynthetic process (GO:0009113)4.29970823
17intracellular estrogen receptor signaling pathway (GO:0030520)4.29462492
18viral transcription (GO:0019083)4.25237663
19DNA replication checkpoint (GO:0000076)4.22408037
20negative regulation of DNA-templated transcription, elongation (GO:0032785)4.22205099
21translational termination (GO:0006415)4.19715485
22ribosomal large subunit biogenesis (GO:0042273)4.16480304
23mitotic recombination (GO:0006312)4.10269643
24apoptotic process involved in morphogenesis (GO:0060561)4.00201187
25proline biosynthetic process (GO:0006561)3.96592544
26ribosomal small subunit biogenesis (GO:0042274)3.91824543
27translational elongation (GO:0006414)3.88028010
28ribonucleoprotein complex biogenesis (GO:0022613)3.87358052
29telomere maintenance via telomere lengthening (GO:0010833)3.87148713
30peptidyl-arginine omega-N-methylation (GO:0035247)3.86695320
31IMP biosynthetic process (GO:0006188)3.86581772
32negative regulation of cell size (GO:0045792)3.85489909
33ribosome biogenesis (GO:0042254)3.83152777
34proteasome assembly (GO:0043248)3.80043221
35translational initiation (GO:0006413)3.79545754
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.70259310
37pseudouridine synthesis (GO:0001522)3.69421034
38folic acid-containing compound biosynthetic process (GO:0009396)3.67188460
39negative regulation of telomerase activity (GO:0051974)3.66840573
40regulation of translational fidelity (GO:0006450)3.66226935
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.65669961
42protein localization to kinetochore (GO:0034501)3.65362732
43UV protection (GO:0009650)3.62993033
44spliceosomal snRNP assembly (GO:0000387)3.60154573
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59289978
46CENP-A containing nucleosome assembly (GO:0034080)3.58087130
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.57616282
48ribosome assembly (GO:0042255)3.56089257
49thymic T cell selection (GO:0045061)3.55975169
50rRNA processing (GO:0006364)3.55482940
51DNA replication-dependent nucleosome assembly (GO:0006335)3.55199345
52DNA replication-dependent nucleosome organization (GO:0034723)3.55199345
53chromatin remodeling at centromere (GO:0031055)3.52445665
54mitotic metaphase plate congression (GO:0007080)3.51438570
55cotranslational protein targeting to membrane (GO:0006613)3.49870075
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.49640856
573-UTR-mediated mRNA stabilization (GO:0070935)3.49542726
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47839957
59protein targeting to ER (GO:0045047)3.47468104
60mitotic nuclear envelope disassembly (GO:0007077)3.46996155
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46830990
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45161461
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44922669
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43230791
65rRNA metabolic process (GO:0016072)3.42748860
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40101403
67regulation of chromatin binding (GO:0035561)3.40087056
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39073937
69Golgi transport vesicle coating (GO:0048200)3.34883037
70COPI coating of Golgi vesicle (GO:0048205)3.34883037
71cellular protein complex disassembly (GO:0043624)3.32898268
72positive regulation of synapse maturation (GO:0090129)3.32135702
73protein insertion into membrane (GO:0051205)3.32120871
74IMP metabolic process (GO:0046040)3.32014491
75histone H4 deacetylation (GO:0070933)3.31623241
76positive regulation of histone deacetylation (GO:0031065)3.30471448
77transcription-coupled nucleotide-excision repair (GO:0006283)3.30234876
78DNA replication-independent nucleosome organization (GO:0034724)3.29496087
79DNA replication-independent nucleosome assembly (GO:0006336)3.29496087
80modulation by virus of host process (GO:0019054)3.28253702
81protein localization to endoplasmic reticulum (GO:0070972)3.28150360
82viral life cycle (GO:0019058)3.27409887
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.27106861
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26741153
85negative regulation of ligase activity (GO:0051352)3.26741153
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.25734910
87folic acid metabolic process (GO:0046655)3.25557726
88planar cell polarity pathway involved in neural tube closure (GO:0090179)3.21734105
89* snRNA metabolic process (GO:0016073)3.18879071
90protein localization to chromosome, centromeric region (GO:0071459)3.17137918
91negative regulation of myotube differentiation (GO:0010832)3.17095768
92regulation of mammary gland epithelial cell proliferation (GO:0033599)3.16443731
93membrane disassembly (GO:0030397)3.16283405
94nuclear envelope disassembly (GO:0051081)3.16283405
95activation of MAPKKK activity (GO:0000185)3.16245455
96metaphase plate congression (GO:0051310)3.15426340
97negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.14042780
98negative regulation of viral release from host cell (GO:1902187)3.13040248
99G1/S transition of mitotic cell cycle (GO:0000082)3.12459817
100cell cycle G1/S phase transition (GO:0044843)3.12459817
101translation (GO:0006412)3.11826046
102histone H3 deacetylation (GO:0070932)3.10859663
103regulation of ARF GTPase activity (GO:0032312)3.10656932
104activation of Rac GTPase activity (GO:0032863)3.10577650
105DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09348650
106positive regulation of gene expression, epigenetic (GO:0045815)3.07842670
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06479282
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06479282
109cellular response to virus (GO:0098586)3.06465601
110signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06245120
111signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06245120
112signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06245120
113positive thymic T cell selection (GO:0045059)3.06011329
114ncRNA 3-end processing (GO:0043628)3.04944083
115signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04692006
116signal transduction involved in DNA damage checkpoint (GO:0072422)3.04692006
117transcription elongation from RNA polymerase III promoter (GO:0006385)3.03978479
118termination of RNA polymerase III transcription (GO:0006386)3.03978479
119creatine metabolic process (GO:0006600)3.02940351
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02832924
121protein complex disassembly (GO:0043241)3.01892097
122viral mRNA export from host cell nucleus (GO:0046784)3.01708626
123signal transduction involved in cell cycle checkpoint (GO:0072395)3.00720574
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95740530
125telomere maintenance (GO:0000723)2.93983276
126telomere organization (GO:0032200)2.93812359
127semaphorin-plexin signaling pathway (GO:0071526)2.92823833
128iron-sulfur cluster assembly (GO:0016226)2.92731869
129metallo-sulfur cluster assembly (GO:0031163)2.92731869
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.92588070
131regulation of cellular amino acid metabolic process (GO:0006521)2.92571850
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92204752
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.92204752
134proline metabolic process (GO:0006560)2.91513147
135histone arginine methylation (GO:0034969)2.91234395
136cellular component biogenesis (GO:0044085)2.91143038
137protein-DNA complex disassembly (GO:0032986)2.90085546
138nucleosome disassembly (GO:0006337)2.90085546
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.90039380
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89947251
141retrograde transport, endosome to Golgi (GO:0042147)2.89288099
142spliceosomal complex assembly (GO:0000245)2.88785839
143macromolecular complex disassembly (GO:0032984)2.88628434
144histone exchange (GO:0043486)2.88465135
145protein retention in ER lumen (GO:0006621)2.88102127
146DNA duplex unwinding (GO:0032508)2.85810232
147NIK/NF-kappaB signaling (GO:0038061)2.85145567
148DNA geometric change (GO:0032392)2.84246299
149intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.83341541
150positive regulation of ligase activity (GO:0051351)2.82775311
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82772358
152attachment of spindle microtubules to kinetochore (GO:0008608)2.82434325
153establishment of chromosome localization (GO:0051303)2.81987474
154adherens junction assembly (GO:0034333)2.80399924
155rRNA modification (GO:0000154)2.79901989
156* ncRNA processing (GO:0034470)2.79217006
157negative regulation of B cell apoptotic process (GO:0002903)2.78408354
158heterochromatin organization (GO:0070828)2.75242548
159regulation of NFAT protein import into nucleus (GO:0051532)2.73595014
160* snRNA processing (GO:0016180)2.72705905
161regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72256542
162modulation by symbiont of host cellular process (GO:0044068)2.69867225
163peptidyl-arginine N-methylation (GO:0035246)2.69760404
164peptidyl-arginine methylation (GO:0018216)2.69760404
165positive regulation of protein dephosphorylation (GO:0035307)2.69249229
1662-oxoglutarate metabolic process (GO:0006103)2.66416619
167focal adhesion assembly (GO:0048041)2.66313009
168cell-substrate adherens junction assembly (GO:0007045)2.66313009
169positive regulation of protein deacetylation (GO:0090312)2.66312424
170regulation of hydrogen peroxide metabolic process (GO:0010310)2.65068130
171apoptotic process involved in development (GO:1902742)2.63947285
172endothelial cell chemotaxis (GO:0035767)2.63337104
173atrioventricular valve morphogenesis (GO:0003181)2.61681835
174positive regulation of protein kinase C signaling (GO:0090037)2.61451385
175DNA damage induced protein phosphorylation (GO:0006975)2.61364452
176entrainment of circadian clock by photoperiod (GO:0043153)2.59910270
177misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.58849298
178maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.58815589
179modulation by virus of host morphology or physiology (GO:0019048)2.58672462
180cellular response to interleukin-4 (GO:0071353)2.57663274
181cell-cell junction maintenance (GO:0045217)2.56681951
182regulation of telomerase activity (GO:0051972)2.55795936
183antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55551725
184positive regulation of CREB transcription factor activity (GO:0032793)2.54876150
185regulation of synapse maturation (GO:0090128)2.50794814
186negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.49843535
187response to interleukin-4 (GO:0070670)2.48818770
188mitotic chromosome condensation (GO:0007076)2.48254553
189mitotic G1 DNA damage checkpoint (GO:0031571)2.48198874
190mitotic G1/S transition checkpoint (GO:0044819)2.47106221
191regulation of cholesterol biosynthetic process (GO:0045540)2.46815592
192phosphatidylglycerol biosynthetic process (GO:0006655)2.46577180
193regulation of histone H3-K27 methylation (GO:0061085)2.45503764
194oxaloacetate metabolic process (GO:0006107)2.43959180
195cell migration in hindbrain (GO:0021535)2.43810454
196antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43417856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.99290092
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.21375583
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93639900
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22736178
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17180592
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.12785385
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05664219
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.01308554
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.96401217
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96128826
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93804993
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.88700639
13* LXR_22292898_ChIP-Seq_THP-1_Human2.84444749
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79545715
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71050570
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69446925
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52612122
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40405602
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36740803
20XRN2_22483619_ChIP-Seq_HELA_Human2.36276438
21VDR_23849224_ChIP-Seq_CD4+_Human2.31576261
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31038530
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25452497
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.24713630
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19317328
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14677559
27P68_20966046_ChIP-Seq_HELA_Human2.13812671
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09358409
29FOXP3_21729870_ChIP-Seq_TREG_Human2.08740313
30RACK7_27058665_Chip-Seq_MCF-7_Human2.07532225
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06598265
32DCP1A_22483619_ChIP-Seq_HELA_Human2.01230584
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00855948
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98566505
35KDM2B_26808549_Chip-Seq_DND41_Human1.96613093
36* GABP_19822575_ChIP-Seq_HepG2_Human1.96212449
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94347059
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92843970
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.86322754
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86028438
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84934362
42TTF2_22483619_ChIP-Seq_HELA_Human1.83868555
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83427145
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82820006
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.79867306
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79034675
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76813249
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.76039673
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73826822
50TCF7_22412390_ChIP-Seq_EML_Mouse1.73522223
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73442225
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.73404381
53CIITA_25753668_ChIP-Seq_RAJI_Human1.72543136
54AR_21909140_ChIP-Seq_LNCAP_Human1.72528782
55MYC_22102868_ChIP-Seq_BL_Human1.70615536
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70314520
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.70182538
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70099900
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.69169005
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68480229
61MAF_26560356_Chip-Seq_TH2_Human1.66777051
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66069657
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63439066
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.62321176
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62030273
66SMC4_20622854_ChIP-Seq_HELA_Human1.61991558
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61619811
68BCOR_27268052_Chip-Seq_Bcells_Human1.60924375
69BCL6_27268052_Chip-Seq_Bcells_Human1.58930239
70MAF_26560356_Chip-Seq_TH1_Human1.58116178
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56576749
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54976296
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.54594720
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53378958
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52957182
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.50641123
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48736065
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48236601
79ELK1_19687146_ChIP-ChIP_HELA_Human1.47845250
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47033377
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46198819
82KDM2B_26808549_Chip-Seq_K562_Human1.45597204
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44860186
84* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44647040
85* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43762569
86PHF8_20622854_ChIP-Seq_HELA_Human1.41551161
87CREB1_26743006_Chip-Seq_LNCaP_Human1.40918248
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40452362
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39768676
90* KDM5A_27292631_Chip-Seq_BREAST_Human1.37418635
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36762144
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36499191
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34633290
94CTCF_27219007_Chip-Seq_Bcells_Human1.33974759
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.33589715
96VDR_24763502_ChIP-Seq_THP-1_Human1.33566590
97NCOR1_26117541_ChIP-Seq_K562_Human1.33400432
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32886116
99* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31517033
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31435668
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30110938
102* E2F1_20622854_ChIP-Seq_HELA_Human1.29459690
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29212243
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.28887613
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25749810
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25597130
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25189028
108* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24099018
109SA1_27219007_Chip-Seq_Bcells_Human1.23981398
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.23693926
111RARB_24833708_ChIP-Seq_LIVER_Mouse1.22256869
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22224725
113FOXP1_21924763_ChIP-Seq_HESCs_Human1.20962473
114VDR_21846776_ChIP-Seq_THP-1_Human1.20150345
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19709924
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18632548
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18201147
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17856177
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17560753
120RARA_24833708_ChIP-Seq_LIVER_Mouse1.17282460
121TP53_22127205_ChIP-Seq_IMR90_Human1.16915429
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15980610
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15872550
124TFEB_21752829_ChIP-Seq_HELA_Human1.15786387
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.15286623
126PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14986057
127RUNX1_22412390_ChIP-Seq_EML_Mouse1.14133973
128* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13481176
129STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13323913
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12553113
131CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11463556
132ETS1_21867929_ChIP-Seq_TH2_Mouse1.11029507
133* CTCF_21964334_Chip-Seq_Bcells_Human1.10911315
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09880638
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09310408
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08952964
137CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07826149
138GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07745469
139SPI1_23547873_ChIP-Seq_NB4_Human1.07550225
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07125688
141SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06274362
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05853534
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04958997
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04881111
145ATF3_27146783_Chip-Seq_COLON_Human1.03695463
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03262042
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02540026
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02532525
149KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00841352
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00330853
151PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98429482
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97920429
153MYC_18940864_ChIP-ChIP_HL60_Human0.96531559
154IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94061765
155CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93150870
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93112556
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92895032
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91423363
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91078196
160ELK1_22589737_ChIP-Seq_MCF10A_Human0.91011101
161ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88754012
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88424748
163CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86478195
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86199276
165* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84867867
166TP63_19390658_ChIP-ChIP_HaCaT_Human0.83683486
167ZNF263_19887448_ChIP-Seq_K562_Human0.80775791
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80688803
169RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78129386
170FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77449579
171UTX_26944678_Chip-Seq_JUKART_Human0.74950840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.55331918
2MP0010094_abnormal_chromosome_stability4.54551007
3MP0003111_abnormal_nucleus_morphology4.52292176
4MP0004957_abnormal_blastocyst_morpholog4.25780348
5MP0003077_abnormal_cell_cycle3.94282372
6MP0008057_abnormal_DNA_replication3.76996604
7MP0008058_abnormal_DNA_repair3.35260397
8MP0003705_abnormal_hypodermis_morpholog3.17912780
9MP0005058_abnormal_lysosome_morphology3.16895886
10MP0008007_abnormal_cellular_replicative3.11068894
11MP0002396_abnormal_hematopoietic_system2.89700143
12MP0004858_abnormal_nervous_system2.81385633
13MP0009278_abnormal_bone_marrow2.70050425
14MP0005451_abnormal_body_composition2.63840816
15MP0005076_abnormal_cell_differentiation2.63442379
16MP0008932_abnormal_embryonic_tissue2.62930296
17MP0000678_abnormal_parathyroid_gland2.62091939
18MP0001348_abnormal_lacrimal_gland2.55057043
19MP0000751_myopathy2.51311103
20MP0003786_premature_aging2.30747496
21MP0003172_abnormal_lysosome_physiology2.20936272
22MP0001730_embryonic_growth_arrest2.18687638
23MP0002249_abnormal_larynx_morphology2.17883944
24MP0003763_abnormal_thymus_physiology2.16495446
25MP0001849_ear_inflammation2.14955717
26MP0000350_abnormal_cell_proliferation2.13631540
27MP0009333_abnormal_splenocyte_physiolog2.06008599
28MP0000490_abnormal_crypts_of2.05288015
29MP0010352_gastrointestinal_tract_polyps1.98191927
30MP0004185_abnormal_adipocyte_glucose1.87988260
31MP0000003_abnormal_adipose_tissue1.82907961
32MP0003806_abnormal_nucleotide_metabolis1.72125867
33MP0004381_abnormal_hair_follicle1.71318413
34MP0000747_muscle_weakness1.71277723
35MP0003123_paternal_imprinting1.64938253
36MP0010307_abnormal_tumor_latency1.63945836
37MP0002019_abnormal_tumor_incidence1.63941928
38MP0004808_abnormal_hematopoietic_stem1.60325448
39MP0002398_abnormal_bone_marrow1.57866729
40MP0000313_abnormal_cell_death1.56149821
41MP0005075_abnormal_melanosome_morpholog1.55829718
42MP0001697_abnormal_embryo_size1.53819584
43MP0003718_maternal_effect1.53668637
44MP0002080_prenatal_lethality1.53390032
45MP0008877_abnormal_DNA_methylation1.52275373
46MP0002722_abnormal_immune_system1.49082547
47MP0000703_abnormal_thymus_morphology1.47544087
48MP0004947_skin_inflammation1.45826835
49MP0005380_embryogenesis_phenotype1.44092309
50MP0001672_abnormal_embryogenesis/_devel1.44092309
51MP0000689_abnormal_spleen_morphology1.42844654
52MP0005375_adipose_tissue_phenotype1.41619626
53MP0005671_abnormal_response_to1.40108401
54MP0000537_abnormal_urethra_morphology1.39667973
55MP0005397_hematopoietic_system_phenotyp1.39450653
56MP0001545_abnormal_hematopoietic_system1.39450653
57MP0005666_abnormal_adipose_tissue1.38142141
58MP0003329_amyloid_beta_deposits1.37018113
59MP0004233_abnormal_muscle_weight1.33623782
60MP0000685_abnormal_immune_system1.30416423
61MP0003984_embryonic_growth_retardation1.28887575
62MP0002429_abnormal_blood_cell1.27111067
63MP0001835_abnormal_antigen_presentation1.26158824
64MP0002088_abnormal_embryonic_growth/wei1.25774783
65MP0010030_abnormal_orbit_morphology1.23726595
66MP0003453_abnormal_keratinocyte_physiol1.23588445
67MP0003567_abnormal_fetal_cardiomyocyte1.21139524
68MP0000759_abnormal_skeletal_muscle1.19650574
69MP0002089_abnormal_postnatal_growth/wei1.17949703
70MP0001502_abnormal_circadian_rhythm1.17263536
71MP0000716_abnormal_immune_system1.17138832
72MP0002085_abnormal_embryonic_tissue1.16134625
73MP0000358_abnormal_cell_content/1.16063733
74MP0002086_abnormal_extraembryonic_tissu1.12223191
75MP0001800_abnormal_humoral_immune1.11904985
76MP0002132_abnormal_respiratory_system1.09316454
77MP0005330_cardiomyopathy1.09047799
78MP0002933_joint_inflammation1.08578916
79MP0003646_muscle_fatigue1.06762914
80MP0001346_abnormal_lacrimal_gland1.06677723
81MP0002420_abnormal_adaptive_immunity1.06439591
82MP0003186_abnormal_redox_activity1.05975622
83MP0009384_cardiac_valve_regurgitation1.05538010
84MP0001819_abnormal_immune_cell1.05140017
85MP0001853_heart_inflammation1.05116962
86MP0009379_abnormal_foot_pigmentation1.04773431
87MP0002210_abnormal_sex_determination1.04393669
88MP0006292_abnormal_olfactory_placode1.03469537
89MP0000750_abnormal_muscle_regeneration1.02646646
90MP0002084_abnormal_developmental_patter1.01483458
91MP0002254_reproductive_system_inflammat1.01217334
92MP0003315_abnormal_perineum_morphology1.01087374
93MP0003436_decreased_susceptibility_to1.00174677
94MP0005083_abnormal_biliary_tract0.99007171
95MP0002452_abnormal_antigen_presenting0.98938831
96MP0001661_extended_life_span0.98381001
97MP0000566_synostosis0.98024422
98MP0006054_spinal_hemorrhage0.97778906
99MP0004197_abnormal_fetal_growth/weight/0.97674155
100MP0000858_altered_metastatic_potential0.95918195
101MP0002723_abnormal_immune_serum0.95099488
102MP0009785_altered_susceptibility_to0.94818483
103MP0008995_early_reproductive_senescence0.94314445
104MP0001145_abnormal_male_reproductive0.93943878
105MP0008260_abnormal_autophagy0.93406027
106MP0009672_abnormal_birth_weight0.92853250
107MP0000681_abnormal_thyroid_gland0.92792373
108MP0002970_abnormal_white_adipose0.92589338
109MP0003303_peritoneal_inflammation0.90540727
110MP0005409_darkened_coat_color0.89899898
111MP0002160_abnormal_reproductive_system0.89845101
112MP0005174_abnormal_tail_pigmentation0.89762135
113MP0000733_abnormal_muscle_development0.88719224
114MP0003221_abnormal_cardiomyocyte_apopto0.88716774
115MP0001293_anophthalmia0.88664496
116MP0009931_abnormal_skin_appearance0.88417834
117MP0006035_abnormal_mitochondrial_morpho0.88189386
118MP0002166_altered_tumor_susceptibility0.86584580
119MP0006036_abnormal_mitochondrial_physio0.85567745
120MP0005023_abnormal_wound_healing0.84512997
121MP0004087_abnormal_muscle_fiber0.84510652
122MP0002405_respiratory_system_inflammati0.83699278
123MP0005025_abnormal_response_to0.82385786
124MP0004130_abnormal_muscle_cell0.81215829
125MP0001790_abnormal_immune_system0.80269882
126MP0005387_immune_system_phenotype0.80269882
127MP0005000_abnormal_immune_tolerance0.79012145
128MP0001929_abnormal_gametogenesis0.78732947
129MP0003879_abnormal_hair_cell0.78693830
130MP0005384_cellular_phenotype0.78636300
131MP0000015_abnormal_ear_pigmentation0.78612912
132MP0002006_tumorigenesis0.78292891
133MP0010155_abnormal_intestine_physiology0.78255949
134MP0005670_abnormal_white_adipose0.77906492
135MP0003566_abnormal_cell_adhesion0.77581816
136MP0002653_abnormal_ependyma_morphology0.76408347
137MP0000653_abnormal_sex_gland0.76188957
138MP0000477_abnormal_intestine_morphology0.75205167
139MP0008961_abnormal_basal_metabolism0.75085536
140MP0000465_gastrointestinal_hemorrhage0.73728973
141MP0001958_emphysema0.73252448
142MP0002095_abnormal_skin_pigmentation0.72437436
143MP0005621_abnormal_cell_physiology0.72094332
144MP0004859_abnormal_synaptic_plasticity0.71819300
145MP0004145_abnormal_muscle_electrophysio0.70532828
146MP0004510_myositis0.69739989
147MP0005389_reproductive_system_phenotype0.65891617
148MP0005501_abnormal_skin_physiology0.64861377
149MP0001873_stomach_inflammation0.64113757
150MP0005464_abnormal_platelet_physiology0.63456591
151MP0001119_abnormal_female_reproductive0.62854070
152MP0001764_abnormal_homeostasis0.59180344
153MP0003866_abnormal_defecation0.57442720
154MP0002148_abnormal_hypersensitivity_rea0.56215186
155MP0009840_abnormal_foam_cell0.54533894
156MP0003890_abnormal_embryonic-extraembry0.53460976
157MP0001845_abnormal_inflammatory_respons0.52421285

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.96063856
2Reticulocytopenia (HP:0001896)4.77582286
3Abnormality of cells of the erythroid lineage (HP:0012130)4.59148350
4Aplastic anemia (HP:0001915)4.48122801
5Abnormal number of erythroid precursors (HP:0012131)4.47706917
6Testicular atrophy (HP:0000029)4.05341633
7Hyperacusis (HP:0010780)3.94617534
8Myopathic facies (HP:0002058)3.89497977
9Breast hypoplasia (HP:0003187)3.84538814
10Oral leukoplakia (HP:0002745)3.65723294
11Stridor (HP:0010307)3.49724147
12Cerebral hypomyelination (HP:0006808)3.46859158
13Ragged-red muscle fibers (HP:0003200)3.43454121
14Colon cancer (HP:0003003)3.42501403
15Macrocytic anemia (HP:0001972)3.42092449
16Increased connective tissue (HP:0009025)3.37115744
17Broad face (HP:0000283)3.33818774
18Rough bone trabeculation (HP:0100670)3.25252333
19Truncus arteriosus (HP:0001660)3.25247302
20Abnormality of the anterior horn cell (HP:0006802)3.22439561
21Degeneration of anterior horn cells (HP:0002398)3.22439561
22Obstructive sleep apnea (HP:0002870)3.20462561
23Pallor (HP:0000980)3.16725326
24Chromsome breakage (HP:0040012)3.13527125
25Selective tooth agenesis (HP:0001592)3.13475236
26Carpal bone hypoplasia (HP:0001498)3.09616649
27Microretrognathia (HP:0000308)3.00319052
28Distal upper limb amyotrophy (HP:0007149)2.97867584
29Upper limb amyotrophy (HP:0009129)2.97867584
3011 pairs of ribs (HP:0000878)2.96334525
31Broad distal phalanx of finger (HP:0009836)2.96162387
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.94690635
33Ulnar bowing (HP:0003031)2.93998051
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92889913
35Thrombocytosis (HP:0001894)2.91202026
36Patellar aplasia (HP:0006443)2.86667541
37Ependymoma (HP:0002888)2.81857076
38Thin bony cortex (HP:0002753)2.79230636
39Agnosia (HP:0010524)2.78166838
40Abnormality of the preputium (HP:0100587)2.77112507
41Cholecystitis (HP:0001082)2.75932720
42Abnormal gallbladder physiology (HP:0012438)2.75932720
43Aplasia/Hypoplasia of the patella (HP:0006498)2.75355052
44Annular pancreas (HP:0001734)2.73125381
45Meckel diverticulum (HP:0002245)2.70895549
46Biconcave vertebral bodies (HP:0004586)2.70022501
47Multiple enchondromatosis (HP:0005701)2.69713934
48Medulloblastoma (HP:0002885)2.69633426
49Absent thumb (HP:0009777)2.66868039
50Trismus (HP:0000211)2.62303363
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61964937
52Hypertensive crisis (HP:0100735)2.60751222
53Abnormality of the ileum (HP:0001549)2.60031062
54Colitis (HP:0002583)2.58257732
55Distal lower limb amyotrophy (HP:0008944)2.55812375
56IgM deficiency (HP:0002850)2.54752938
57Abnormality of the fingertips (HP:0001211)2.53108494
58Abnormality of chromosome stability (HP:0003220)2.50838689
59Atelectasis (HP:0100750)2.50652788
60Myelodysplasia (HP:0002863)2.47681756
61Hyperthyroidism (HP:0000836)2.47168770
62Neoplasm of the pancreas (HP:0002894)2.46630896
63Premature graying of hair (HP:0002216)2.43952032
64Bone marrow hypocellularity (HP:0005528)2.43333750
65Pancytopenia (HP:0001876)2.42982039
66Difficulty climbing stairs (HP:0003551)2.42981686
67Seborrheic dermatitis (HP:0001051)2.40715000
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39767538
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39767538
70Premature ovarian failure (HP:0008209)2.39602193
71Muscle fiber atrophy (HP:0100295)2.39129718
72Insomnia (HP:0100785)2.37297089
73Progressive external ophthalmoplegia (HP:0000590)2.34500801
74Lymphoma (HP:0002665)2.34458385
75Hemorrhage of the eye (HP:0011885)2.33966242
76Achilles tendon contracture (HP:0001771)2.33557443
77Type I transferrin isoform profile (HP:0003642)2.33445186
78Easy fatigability (HP:0003388)2.33079332
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.33038845
80Long palpebral fissure (HP:0000637)2.30308397
81Secondary amenorrhea (HP:0000869)2.29526627
82Hand muscle atrophy (HP:0009130)2.28779247
83Exercise-induced myalgia (HP:0003738)2.27112367
84J-shaped sella turcica (HP:0002680)2.26580430
85Type 2 muscle fiber atrophy (HP:0003554)2.26450493
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.25794530
87Poikiloderma (HP:0001029)2.25154054
88Abnormal trabecular bone morphology (HP:0100671)2.24561395
89Impulsivity (HP:0100710)2.24138358
90Basal cell carcinoma (HP:0002671)2.24055111
91Reticulocytosis (HP:0001923)2.23972687
92Megaloblastic anemia (HP:0001889)2.20558638
93Pointed chin (HP:0000307)2.20522502
94Vertebral compression fractures (HP:0002953)2.19035452
95Entropion (HP:0000621)2.18901311
96Slender long bone (HP:0003100)2.18634787
97Rectal prolapse (HP:0002035)2.18385928
98Abnormality of the aortic arch (HP:0012303)2.16899406
99Duodenal stenosis (HP:0100867)2.16455735
100Small intestinal stenosis (HP:0012848)2.16455735
101Cervical subluxation (HP:0003308)2.15172545
102Deep palmar crease (HP:0006191)2.12407753
103Increased serum lactate (HP:0002151)2.12317247
104Abnormality of DNA repair (HP:0003254)2.12252927
105Horseshoe kidney (HP:0000085)2.11403702
106Cellular immunodeficiency (HP:0005374)2.10968860
107Tracheoesophageal fistula (HP:0002575)2.10281423
108External ophthalmoplegia (HP:0000544)2.10279741
109Joint stiffness (HP:0001387)2.09312674
110Atrophy/Degeneration involving motor neurons (HP:0007373)2.09148306
111Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08627770
112Increased cerebral lipofuscin (HP:0011813)2.08442054
113Poor head control (HP:0002421)2.07068293
114Elevated erythrocyte sedimentation rate (HP:0003565)2.07016620
115Cleft eyelid (HP:0000625)2.06353795
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05559156
117Petechiae (HP:0000967)2.05213222
118Amaurosis fugax (HP:0100576)2.03460885
119Progressive muscle weakness (HP:0003323)2.03352559
120Diaphragmatic weakness (HP:0009113)2.02937105
121Abnormality of the thoracic spine (HP:0100711)2.02894117
122Rhabdomyosarcoma (HP:0002859)2.02454616
123Gastrointestinal dysmotility (HP:0002579)2.01672384
124CNS hypomyelination (HP:0003429)2.01371140
125Thoracic kyphosis (HP:0002942)2.00732756
126Sloping forehead (HP:0000340)2.00276669
127Disproportionate tall stature (HP:0001519)1.99938526
128Gastrointestinal inflammation (HP:0004386)1.99662831
129Abnormality of pyrimidine metabolism (HP:0004353)1.98915842
130Bowel incontinence (HP:0002607)1.98651048
131Absent radius (HP:0003974)1.98042660
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97804980
133Microvesicular hepatic steatosis (HP:0001414)1.97164984
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96216048
135Thin ribs (HP:0000883)1.96002058
136Hepatocellular necrosis (HP:0001404)1.95220235
137Bronchomalacia (HP:0002780)1.94537252
138Abnormality of the Achilles tendon (HP:0005109)1.94148333
139Optic nerve coloboma (HP:0000588)1.91879758
140Squamous cell carcinoma (HP:0002860)1.91871033
141Abnormality of reticulocytes (HP:0004312)1.91617133
142IgG deficiency (HP:0004315)1.91456222
143Exertional dyspnea (HP:0002875)1.91040167
144Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90969054
145Triphalangeal thumb (HP:0001199)1.90819060
146Metaphyseal cupping (HP:0003021)1.89838368
147Increased variability in muscle fiber diameter (HP:0003557)1.87872343
148Glossoptosis (HP:0000162)1.87225858
149Missing ribs (HP:0000921)1.87027263
150Abnormal large intestine physiology (HP:0012700)1.87020911
151Abnormal lung lobation (HP:0002101)1.86271350
152Premature skin wrinkling (HP:0100678)1.84798625
153Emphysema (HP:0002097)1.84586831
154Bowed forearm bones (HP:0003956)1.84307720
155Bowing of the arm (HP:0006488)1.84307720
156Dysmetric saccades (HP:0000641)1.83535494
157Cholelithiasis (HP:0001081)1.83325192
158Turricephaly (HP:0000262)1.82952814
159Abnormality of T cell physiology (HP:0011840)1.82566025
160Abnormal number of incisors (HP:0011064)1.81721168
161Tongue fasciculations (HP:0001308)1.81527326
162Abnormality of T cells (HP:0002843)1.80606346
163Aplasia involving forearm bones (HP:0009822)1.80374007
164Absent forearm bone (HP:0003953)1.80374007
165Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78494457
166Severe visual impairment (HP:0001141)1.78026680
167Abnormality of the duodenum (HP:0002246)1.77678091
168Sparse eyelashes (HP:0000653)1.77085871
169Patellar dislocation (HP:0002999)1.76723071
170Hypoparathyroidism (HP:0000829)1.76595082
171Personality changes (HP:0000751)1.75003468
172Ankle clonus (HP:0011448)1.74861934
173Abnormal spermatogenesis (HP:0008669)1.74484681
174Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73494994
175Absent epiphyses (HP:0010577)1.73494994
176Distal lower limb muscle weakness (HP:0009053)1.73222751
177Mitral regurgitation (HP:0001653)1.73169052
178Delayed epiphyseal ossification (HP:0002663)1.71192979
179Dysautonomia (HP:0002459)1.70495690
180Abnormality of skeletal muscle fiber size (HP:0012084)1.70477277
181Mildly elevated creatine phosphokinase (HP:0008180)1.69828702
182Lower limb amyotrophy (HP:0007210)1.68067987
183Cellulitis (HP:0100658)1.67394411
184Dislocated radial head (HP:0003083)1.67056522
185Increased IgE level (HP:0003212)1.66500645
186Cerebral aneurysm (HP:0004944)1.65897611
187Obstructive lung disease (HP:0006536)1.63749774
188Chronic obstructive pulmonary disease (HP:0006510)1.63749774
189Elfin facies (HP:0004428)1.63082489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.36242245
2BUB14.89443336
3WEE14.38027491
4STK163.64690710
5CDC73.19432559
6SMG13.09364267
7ERN12.93479560
8EIF2AK12.88420375
9ICK2.83793230
10NME22.70098513
11TSSK62.70091842
12SIK12.58607423
13NEK22.48661817
14TLK12.39108615
15PRPF4B2.32381831
16SRPK12.29364109
17TESK22.29028784
18ACVR1B2.08529802
19SIK21.95959482
20RIPK11.93173363
21KDR1.82126037
22BRSK21.77658961
23IRAK31.74712055
24TTK1.70360714
25NEK11.70208883
26MAP4K11.69879599
27EIF2AK31.68869687
28PLK11.68580400
29RPS6KB21.68247716
30MAP2K61.68182045
31VRK11.67044581
32TNK21.66786316
33PLK41.63193859
34EPHA21.58600339
35MARK21.54518950
36PIM21.54405086
37PRKD31.50912568
38PASK1.50506949
39CDK71.46018426
40AURKB1.44910020
41SCYL21.44864746
42ATR1.44398061
43DYRK31.43859884
44CCNB11.38085797
45TTN1.36145206
46FGFR41.34587355
47PRKD21.31500055
48AURKA1.22273758
49BCKDK1.22131190
50EPHB11.21335573
51BRSK11.20191783
52MAP3K131.17488011
53MKNK11.17450134
54MAPK151.17381505
55RPS6KA41.16637581
56MAP3K71.15000632
57PTK61.14322631
58PLK31.13879732
59PAK41.13721689
60BMX1.13688839
61EEF2K1.12958348
62MAP3K81.12515455
63TGFBR11.12379693
64CAMKK11.12088565
65FLT31.11213295
66CDC42BPA1.10810812
67MTOR1.06783201
68CHEK21.05112207
69CDK41.01830561
70ZAK1.00038929
71ZAP700.98507242
72ARAF0.96928898
73BLK0.96352117
74MAPK110.95795793
75CHEK10.95212784
76TYRO30.94912610
77MAP3K110.93823539
78NME10.93079797
79RIPK40.91176838
80STK100.88173608
81PDPK10.86550940
82LMTK20.86295423
83RPS6KA20.85596358
84TESK10.84538269
85BTK0.84083333
86PIM10.83948895
87MKNK20.83814534
88MAP2K30.82746041
89RPS6KL10.80479957
90RPS6KC10.80479957
91MST1R0.79700681
92TEC0.78405753
93KIT0.78172037
94IRAK40.77384485
95LRRK20.76742059
96MAPK120.76178938
97CAMK1D0.76075600
98BRAF0.75687869
99MAP3K100.72793028
100RPS6KA60.70530445
101HIPK20.70190962
102TAOK10.69601777
103PRKCI0.68858828
104PKN20.68388798
105TAOK20.67950429
106STK40.67446589
107CSNK2A10.66559955
108TYK20.66305271
109MAPKAPK30.65979592
110CSNK2A20.65924479
111JAK30.64932364
112KSR20.63692686
113CDK20.63574526
114CDK80.63521525
115PAK10.62884065
116TXK0.61773455
117CLK10.59118489
118ATM0.58888032
119MAP3K10.58657365
120EIF2AK20.50807778
121PDK10.50173568
122MAP3K60.49257659
123CSF1R0.48482446
124SIK30.47659131
125MAP3K30.46871313
126NLK0.45987720
127PBK0.45144197
128RPS6KA50.42778981
129PTK20.42765788
130ILK0.41798923
131DYRK1B0.41719002
132NEK90.40844064
133CDK10.40786713
134LYN0.40531031
135GRK60.39840564
136RET0.39387144
137SYK0.38794279
138RPS6KA10.38715344
139WNK40.35590660
140AKT20.33401548
141IKBKB0.33009129
142DYRK20.32862674
143LCK0.32083375
144PRKAA10.31869171
145TBK10.31584589
146CDK120.31345713
147MAPK80.31085572
148PRKCH0.30892759
149ALK0.30301157
150ITK0.29869805
151PRKD10.29854481
152MAP2K20.29538712
153MST40.28883207
154PHKG20.28523051
155MATK0.28006647
156PDK30.25932309

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.16548572
2Mismatch repair_Homo sapiens_hsa034304.26809630
3Proteasome_Homo sapiens_hsa030503.85823809
4Ribosome_Homo sapiens_hsa030103.78997824
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46223366
6RNA polymerase_Homo sapiens_hsa030203.21980665
7Base excision repair_Homo sapiens_hsa034103.15598775
8Spliceosome_Homo sapiens_hsa030403.12145560
9Homologous recombination_Homo sapiens_hsa034402.95566154
10Nucleotide excision repair_Homo sapiens_hsa034202.84766797
11RNA transport_Homo sapiens_hsa030132.82605805
12Pyrimidine metabolism_Homo sapiens_hsa002402.60579689
13Notch signaling pathway_Homo sapiens_hsa043302.59324511
14One carbon pool by folate_Homo sapiens_hsa006702.54323496
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43903922
16Cell cycle_Homo sapiens_hsa041102.30271624
17Fanconi anemia pathway_Homo sapiens_hsa034601.99736485
18VEGF signaling pathway_Homo sapiens_hsa043701.99722894
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.92078708
20Non-homologous end-joining_Homo sapiens_hsa034501.91212397
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.67552781
22RNA degradation_Homo sapiens_hsa030181.66942283
23Basal transcription factors_Homo sapiens_hsa030221.56935422
24p53 signaling pathway_Homo sapiens_hsa041151.56006887
25Non-small cell lung cancer_Homo sapiens_hsa052231.52775401
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46231394
27Lysine degradation_Homo sapiens_hsa003101.44276887
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43310746
29mRNA surveillance pathway_Homo sapiens_hsa030151.31642680
30Purine metabolism_Homo sapiens_hsa002301.31593513
31Sulfur relay system_Homo sapiens_hsa041221.28601859
32Folate biosynthesis_Homo sapiens_hsa007901.26174836
33Epstein-Barr virus infection_Homo sapiens_hsa051691.22890079
34Pentose phosphate pathway_Homo sapiens_hsa000301.18460677
35mTOR signaling pathway_Homo sapiens_hsa041501.16523094
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14956741
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13780424
38Insulin signaling pathway_Homo sapiens_hsa049101.11698989
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11170870
40Primary immunodeficiency_Homo sapiens_hsa053401.10815922
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.08432273
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08269065
43Antigen processing and presentation_Homo sapiens_hsa046121.05875548
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.05651758
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01319187
46Herpes simplex infection_Homo sapiens_hsa051680.99528375
47Systemic lupus erythematosus_Homo sapiens_hsa053220.98819553
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96889686
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.95563067
50GnRH signaling pathway_Homo sapiens_hsa049120.95021748
51Protein export_Homo sapiens_hsa030600.93336575
52Biosynthesis of amino acids_Homo sapiens_hsa012300.92018845
53Prion diseases_Homo sapiens_hsa050200.88055173
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.87407418
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.86848869
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86476801
57Choline metabolism in cancer_Homo sapiens_hsa052310.84099105
58AMPK signaling pathway_Homo sapiens_hsa041520.83871296
59Vitamin B6 metabolism_Homo sapiens_hsa007500.83527568
60Pancreatic cancer_Homo sapiens_hsa052120.81740850
61Viral carcinogenesis_Homo sapiens_hsa052030.80954452
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.80131295
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78326567
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77558846
65ErbB signaling pathway_Homo sapiens_hsa040120.77203058
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76134965
67Hepatitis C_Homo sapiens_hsa051600.75984654
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.75361816
69Insulin resistance_Homo sapiens_hsa049310.74274361
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71113424
71Arginine biosynthesis_Homo sapiens_hsa002200.69254969
72Endometrial cancer_Homo sapiens_hsa052130.68144174
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68134434
74Osteoclast differentiation_Homo sapiens_hsa043800.66903896
75Lysosome_Homo sapiens_hsa041420.66040984
76Legionellosis_Homo sapiens_hsa051340.65042212
77TNF signaling pathway_Homo sapiens_hsa046680.65039655
78Phenylalanine metabolism_Homo sapiens_hsa003600.64618549
79Selenocompound metabolism_Homo sapiens_hsa004500.63866280
80HTLV-I infection_Homo sapiens_hsa051660.63471025
81Glioma_Homo sapiens_hsa052140.62916572
82Inositol phosphate metabolism_Homo sapiens_hsa005620.61143570
83Oocyte meiosis_Homo sapiens_hsa041140.60080737
84Measles_Homo sapiens_hsa051620.58460673
85Endocytosis_Homo sapiens_hsa041440.57458358
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53931144
87Carbon metabolism_Homo sapiens_hsa012000.53681746
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53242014
89Fructose and mannose metabolism_Homo sapiens_hsa000510.51365135
90Thyroid cancer_Homo sapiens_hsa052160.50497689
91Arginine and proline metabolism_Homo sapiens_hsa003300.50293996
92N-Glycan biosynthesis_Homo sapiens_hsa005100.49957996
93Shigellosis_Homo sapiens_hsa051310.49756696
94Apoptosis_Homo sapiens_hsa042100.49243776
95Galactose metabolism_Homo sapiens_hsa000520.48742081
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48659186
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48465002
98Glucagon signaling pathway_Homo sapiens_hsa049220.46860504
99Toxoplasmosis_Homo sapiens_hsa051450.46555552
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45991222
101Glutathione metabolism_Homo sapiens_hsa004800.44131618
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.43302331
103Huntingtons disease_Homo sapiens_hsa050160.42637773
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42277356
105MAPK signaling pathway_Homo sapiens_hsa040100.41491871
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40058935
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39864483
108Estrogen signaling pathway_Homo sapiens_hsa049150.39350761
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39076742
110Parkinsons disease_Homo sapiens_hsa050120.38620482
111Renal cell carcinoma_Homo sapiens_hsa052110.38465543
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38034608
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.37806946
114Small cell lung cancer_Homo sapiens_hsa052220.36688606
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36513431
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36419116
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35770775
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35232443
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33462416
120Hepatitis B_Homo sapiens_hsa051610.33108309
121Hematopoietic cell lineage_Homo sapiens_hsa046400.32862670
122Influenza A_Homo sapiens_hsa051640.30416972
123Allograft rejection_Homo sapiens_hsa053300.29386395
124Other glycan degradation_Homo sapiens_hsa005110.28237217
125Metabolic pathways_Homo sapiens_hsa011000.27551439
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26854198
127Acute myeloid leukemia_Homo sapiens_hsa052210.24231300
128Leishmaniasis_Homo sapiens_hsa051400.22962274
129Bladder cancer_Homo sapiens_hsa052190.22663806
130MicroRNAs in cancer_Homo sapiens_hsa052060.22530207
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21761077
132Alcoholism_Homo sapiens_hsa050340.21019096
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19145195
134HIF-1 signaling pathway_Homo sapiens_hsa040660.18552178
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18541149
136Viral myocarditis_Homo sapiens_hsa054160.18369721
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17736835
138Regulation of autophagy_Homo sapiens_hsa041400.17022102
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.16799378
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16740770
141Colorectal cancer_Homo sapiens_hsa052100.16354116
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16070993
143T cell receptor signaling pathway_Homo sapiens_hsa046600.15951752
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.14645940
145Oxidative phosphorylation_Homo sapiens_hsa001900.13736964
146B cell receptor signaling pathway_Homo sapiens_hsa046620.12763590
147Renin-angiotensin system_Homo sapiens_hsa046140.11002759
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10706253
149Chronic myeloid leukemia_Homo sapiens_hsa052200.10574016

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