CPSF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.03293801
2ribosomal small subunit assembly (GO:0000028)4.82184925
3telomere maintenance via semi-conservative replication (GO:0032201)4.78785520
4DNA strand elongation (GO:0022616)4.78330238
5establishment of integrated proviral latency (GO:0075713)4.55647817
6DNA unwinding involved in DNA replication (GO:0006268)4.44013826
7DNA deamination (GO:0045006)4.43529478
8maturation of SSU-rRNA (GO:0030490)4.39858951
9DNA replication initiation (GO:0006270)4.38831493
10nucleobase biosynthetic process (GO:0046112)4.34199875
11DNA double-strand break processing (GO:0000729)4.33327182
12formation of translation preinitiation complex (GO:0001731)4.30686598
13purine nucleobase biosynthetic process (GO:0009113)4.22072436
14telomere maintenance via recombination (GO:0000722)4.19179094
15IMP biosynthetic process (GO:0006188)4.14178833
16histone exchange (GO:0043486)4.09356937
17mitotic recombination (GO:0006312)4.04525193
18mitotic sister chromatid segregation (GO:0000070)4.03814672
19DNA ligation (GO:0006266)3.94251861
20telomere maintenance via telomere lengthening (GO:0010833)3.88740956
21proteasome assembly (GO:0043248)3.87395577
22sister chromatid segregation (GO:0000819)3.85149043
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.82806110
24viral transcription (GO:0019083)3.80411225
25nuclear pore complex assembly (GO:0051292)3.78241504
26non-recombinational repair (GO:0000726)3.78208670
27double-strand break repair via nonhomologous end joining (GO:0006303)3.78208670
28translational termination (GO:0006415)3.75936199
29spindle checkpoint (GO:0031577)3.71281509
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.71016221
31DNA replication checkpoint (GO:0000076)3.69922273
32ribosome biogenesis (GO:0042254)3.69255144
33ribosomal large subunit biogenesis (GO:0042273)3.69167926
34mitotic spindle checkpoint (GO:0071174)3.65315359
35ribonucleoprotein complex biogenesis (GO:0022613)3.63782933
36ribosomal small subunit biogenesis (GO:0042274)3.61947419
37negative regulation of mitotic sister chromatid separation (GO:2000816)3.61040314
38negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.61040314
39negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.61040314
40negative regulation of chromosome segregation (GO:0051985)3.58758017
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.58587262
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.58587262
43IMP metabolic process (GO:0046040)3.54759969
44mitotic sister chromatid cohesion (GO:0007064)3.54541618
45spliceosomal snRNP assembly (GO:0000387)3.50600294
46regulation of helicase activity (GO:0051095)3.50091242
47translational elongation (GO:0006414)3.50056376
48establishment of viral latency (GO:0019043)3.49405383
49replication fork processing (GO:0031297)3.48560591
50translational initiation (GO:0006413)3.45638539
51CENP-A containing nucleosome assembly (GO:0034080)3.45103433
52DNA catabolic process, exonucleolytic (GO:0000738)3.42496114
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42192371
54DNA damage response, detection of DNA damage (GO:0042769)3.41187644
55mitotic spindle assembly checkpoint (GO:0007094)3.40616915
56chromatin remodeling at centromere (GO:0031055)3.40437527
57mitotic nuclear envelope disassembly (GO:0007077)3.40152655
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39239147
59rRNA processing (GO:0006364)3.37750891
60histone H2A acetylation (GO:0043968)3.37189698
61mitotic metaphase plate congression (GO:0007080)3.36497498
62spindle assembly checkpoint (GO:0071173)3.36358879
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35702218
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35702218
65protein localization to kinetochore (GO:0034501)3.35575601
66L-serine metabolic process (GO:0006563)3.34737221
67cotranslational protein targeting to membrane (GO:0006613)3.30396730
68regulation of centriole replication (GO:0046599)3.30140509
69establishment of chromosome localization (GO:0051303)3.29860589
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.29559688
71regulation of mitotic spindle checkpoint (GO:1903504)3.29559688
72DNA strand renaturation (GO:0000733)3.29395285
73termination of RNA polymerase III transcription (GO:0006386)3.28843929
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.28843929
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28523713
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27842960
77establishment of protein localization to mitochondrial membrane (GO:0090151)3.27657260
78ribosome assembly (GO:0042255)3.27532460
79protein targeting to ER (GO:0045047)3.27373117
80transcription-coupled nucleotide-excision repair (GO:0006283)3.27131437
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26785100
82rRNA metabolic process (GO:0016072)3.26703763
83intra-S DNA damage checkpoint (GO:0031573)3.25856638
84pseudouridine synthesis (GO:0001522)3.25700329
85regulation of sister chromatid segregation (GO:0033045)3.25203285
86regulation of mitotic sister chromatid separation (GO:0010965)3.25203285
87regulation of mitotic sister chromatid segregation (GO:0033047)3.25203285
88regulation of chromosome segregation (GO:0051983)3.24645673
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24200516
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23559799
91cullin deneddylation (GO:0010388)3.19531142
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17672549
93kinetochore organization (GO:0051383)3.16921833
94DNA replication-independent nucleosome organization (GO:0034724)3.16556468
95DNA replication-independent nucleosome assembly (GO:0006336)3.16556468
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16248552
97mitotic chromosome condensation (GO:0007076)3.16144002
98negative regulation of ligase activity (GO:0051352)3.14454191
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14454191
100telomere organization (GO:0032200)3.13199820
101telomere maintenance (GO:0000723)3.12016375
102viral mRNA export from host cell nucleus (GO:0046784)3.10469793
103maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10170825
104DNA topological change (GO:0006265)3.09615921
105regulation of DNA endoreduplication (GO:0032875)3.08896046
106protein localization to endoplasmic reticulum (GO:0070972)3.08890985
107establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07855344
108membrane disassembly (GO:0030397)3.07653425
109nuclear envelope disassembly (GO:0051081)3.07653425
110nuclear pore organization (GO:0006999)3.07618781
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05486173
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04873893
113response to X-ray (GO:0010165)3.04659839
114negative regulation of DNA recombination (GO:0045910)3.04620075
115protein localization to chromosome, centromeric region (GO:0071459)3.03802346
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03396175
117DNA replication-dependent nucleosome assembly (GO:0006335)3.01350156
118DNA replication-dependent nucleosome organization (GO:0034723)3.01350156
119translation (GO:0006412)2.99170900
120spliceosomal complex assembly (GO:0000245)2.99115806
121DNA geometric change (GO:0032392)2.98017761
122DNA duplex unwinding (GO:0032508)2.97667051
123* RNA splicing, via transesterification reactions (GO:0000375)2.96793442
124ATP-dependent chromatin remodeling (GO:0043044)2.96683455
125metaphase plate congression (GO:0051310)2.96618435
126chaperone-mediated protein transport (GO:0072321)2.96616647
127tRNA aminoacylation (GO:0043039)2.96573008
128amino acid activation (GO:0043038)2.96573008
129attachment of spindle microtubules to kinetochore (GO:0008608)2.96257798
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96239810
131* mRNA splicing, via spliceosome (GO:0000398)2.96157987
132* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96157987
133cellular protein complex disassembly (GO:0043624)2.95969390
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94784935
135kinetochore assembly (GO:0051382)2.94633039
136viral life cycle (GO:0019058)2.94578374
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94394274
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94394274
139folic acid-containing compound biosynthetic process (GO:0009396)2.94215274
140signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93888137
141signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93888137
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93888137
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93245766
144tRNA aminoacylation for protein translation (GO:0006418)2.92777053
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.92152842
146signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92152842
147signal transduction involved in cell cycle checkpoint (GO:0072395)2.91590504
148G1/S transition of mitotic cell cycle (GO:0000082)2.91168374
149cell cycle G1/S phase transition (GO:0044843)2.91168374
150negative regulation of sister chromatid segregation (GO:0033046)2.91138017
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91138017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.86310108
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.19678618
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77228794
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40617773
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34130637
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.26288745
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15688677
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.11361157
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.08255377
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.98796405
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90931934
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89300678
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82400069
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80789901
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73547739
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69698707
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58175175
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57758145
19XRN2_22483619_ChIP-Seq_HELA_Human2.49994269
20VDR_23849224_ChIP-Seq_CD4+_Human2.39364938
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37844798
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37704581
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23486301
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.20615657
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11492484
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08333008
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06602811
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06329264
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.05709803
30AR_21909140_ChIP-Seq_LNCAP_Human2.02612101
31GABP_19822575_ChIP-Seq_HepG2_Human2.02017048
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01723888
33DCP1A_22483619_ChIP-Seq_HELA_Human1.97366819
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93256327
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90921220
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.90344360
37TTF2_22483619_ChIP-Seq_HELA_Human1.87442918
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87292865
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84282100
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.79724524
41* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78863684
42CIITA_25753668_ChIP-Seq_RAJI_Human1.77274798
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75202528
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74112465
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73212477
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.72548978
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72505116
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.69592231
49MYC_22102868_ChIP-Seq_BL_Human1.61420506
50ELK1_19687146_ChIP-ChIP_HELA_Human1.61056767
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59451255
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59307129
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57852969
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56722523
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55863271
56* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55791431
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52138271
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49430083
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48621014
60KDM5A_27292631_Chip-Seq_BREAST_Human1.47166283
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47062277
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38379272
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38094366
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35333174
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.33659861
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.32821589
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32444974
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31709667
69EWS_26573619_Chip-Seq_HEK293_Human1.31133437
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26091824
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25807567
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.22687874
73IRF1_19129219_ChIP-ChIP_H3396_Human1.22068656
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21963807
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.16980217
76ZNF274_21170338_ChIP-Seq_K562_Hela1.16544154
77FUS_26573619_Chip-Seq_HEK293_Human1.15776314
78TFEB_21752829_ChIP-Seq_HELA_Human1.14573199
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13516395
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13136160
81VDR_21846776_ChIP-Seq_THP-1_Human1.10324096
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09942219
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08691313
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07441699
85SPI1_23547873_ChIP-Seq_NB4_Human1.06922758
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05291763
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05264875
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05212263
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05106247
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.04863876
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04069862
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02120283
93MYC_18940864_ChIP-ChIP_HL60_Human1.01498851
94* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00224505
95SOX17_20123909_ChIP-Seq_XEN_Mouse1.00077839
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99513979
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96898277
98STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95128587
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94840914
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91050501
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86692301
102* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85232441
103VDR_22108803_ChIP-Seq_LS180_Human0.84474396
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82919019
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82452978
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.82409475
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80707577
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79497567
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79365927
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79075252
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78877477
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77458647
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77414398
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75576990
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75520112
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68946370
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68913862
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67925335
119TCF3_18692474_ChIP-Seq_MEFs_Mouse0.66998510
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.63658813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.93518563
2MP0010094_abnormal_chromosome_stability4.66102540
3MP0004957_abnormal_blastocyst_morpholog4.32261996
4MP0003111_abnormal_nucleus_morphology4.28070121
5MP0003077_abnormal_cell_cycle4.04237312
6MP0008058_abnormal_DNA_repair3.68731550
7MP0008057_abnormal_DNA_replication3.68109052
8MP0008007_abnormal_cellular_replicative3.33967374
9MP0002396_abnormal_hematopoietic_system3.22342073
10MP0008932_abnormal_embryonic_tissue2.61905282
11MP0003941_abnormal_skin_development2.46134932
12MP0003763_abnormal_thymus_physiology2.23682989
13MP0001730_embryonic_growth_arrest2.19992022
14MP0003786_premature_aging2.19962026
15MP0000350_abnormal_cell_proliferation2.16060060
16MP0008877_abnormal_DNA_methylation2.09982882
17MP0004808_abnormal_hematopoietic_stem1.92922978
18MP0003123_paternal_imprinting1.83226059
19MP0010030_abnormal_orbit_morphology1.81765851
20MP0000372_irregular_coat_pigmentation1.74801539
21MP0009333_abnormal_splenocyte_physiolog1.74743343
22MP0000490_abnormal_crypts_of1.73980909
23MP0002102_abnormal_ear_morphology1.68946462
24MP0000313_abnormal_cell_death1.61651420
25MP0003806_abnormal_nucleotide_metabolis1.56611104
26MP0001697_abnormal_embryo_size1.55835171
27MP0002080_prenatal_lethality1.52747051
28MP0001672_abnormal_embryogenesis/_devel1.52187457
29MP0005380_embryogenesis_phenotype1.52187457
30MP0002019_abnormal_tumor_incidence1.52002127
31MP0003937_abnormal_limbs/digits/tail_de1.51246209
32MP0010352_gastrointestinal_tract_polyps1.47866030
33MP0006072_abnormal_retinal_apoptosis1.45258856
34MP0002398_abnormal_bone_marrow1.45045441
35MP0000703_abnormal_thymus_morphology1.41969377
36MP0003984_embryonic_growth_retardation1.41113281
37MP0005394_taste/olfaction_phenotype1.37850218
38MP0005499_abnormal_olfactory_system1.37850218
39MP0002088_abnormal_embryonic_growth/wei1.37131933
40MP0003315_abnormal_perineum_morphology1.36633268
41MP0003718_maternal_effect1.36202459
42MP0000689_abnormal_spleen_morphology1.34302247
43MP0009697_abnormal_copulation1.32690582
44MP0002722_abnormal_immune_system1.32551855
45MP0002085_abnormal_embryonic_tissue1.31064427
46MP0000685_abnormal_immune_system1.30302681
47MP0003121_genomic_imprinting1.30064601
48MP0002233_abnormal_nose_morphology1.29433021
49MP0001293_anophthalmia1.29422395
50MP0000566_synostosis1.29135602
51MP0001286_abnormal_eye_development1.27937175
52MP0005075_abnormal_melanosome_morpholog1.27462672
53MP0001529_abnormal_vocalization1.24849247
54MP0006292_abnormal_olfactory_placode1.16794937
55MP0002653_abnormal_ependyma_morphology1.15873071
56MP0003186_abnormal_redox_activity1.15725162
57MP0001188_hyperpigmentation1.15242152
58MP0010307_abnormal_tumor_latency1.15091242
59MP0003567_abnormal_fetal_cardiomyocyte1.14565829
60MP0002084_abnormal_developmental_patter1.14335965
61MP0005671_abnormal_response_to1.13930280
62MP0003136_yellow_coat_color1.13574542
63MP0002429_abnormal_blood_cell1.13535683
64MP0002234_abnormal_pharynx_morphology1.13353308
65MP0002254_reproductive_system_inflammat1.10695064
66MP0004197_abnormal_fetal_growth/weight/1.09503523
67MP0002210_abnormal_sex_determination1.07855131
68MP0002086_abnormal_extraembryonic_tissu1.07252483
69MP0000716_abnormal_immune_system1.06523276
70MP0001835_abnormal_antigen_presentation1.05839330
71MP0002697_abnormal_eye_size1.05433961
72MP0005397_hematopoietic_system_phenotyp1.03047115
73MP0001545_abnormal_hematopoietic_system1.03047115
74MP0002111_abnormal_tail_morphology1.00483162
75MP0002132_abnormal_respiratory_system1.00229397
76MP0000358_abnormal_cell_content/0.98902516
77MP0004147_increased_porphyrin_level0.98259461
78MP0003119_abnormal_digestive_system0.97230610
79MP0001800_abnormal_humoral_immune0.95597719
80MP0009672_abnormal_birth_weight0.90527029
81MP0002420_abnormal_adaptive_immunity0.89670089
82MP0009703_decreased_birth_body0.89011561
83MP0004133_heterotaxia0.88939149
84MP0002751_abnormal_autonomic_nervous0.87843571
85MP0002095_abnormal_skin_pigmentation0.87809718
86MP0001145_abnormal_male_reproductive0.87194886
87MP0001819_abnormal_immune_cell0.86817672
88MP0005391_vision/eye_phenotype0.85006965
89MP0002092_abnormal_eye_morphology0.84660389
90MP0009053_abnormal_anal_canal0.84427997
91MP0002160_abnormal_reproductive_system0.83442347
92MP0003943_abnormal_hepatobiliary_system0.82962721
93MP0000647_abnormal_sebaceous_gland0.81913254
94MP0001764_abnormal_homeostasis0.80923697
95MP0003755_abnormal_palate_morphology0.80046250
96MP0001929_abnormal_gametogenesis0.79367551
97MP0002938_white_spotting0.78694430
98MP0001119_abnormal_female_reproductive0.78613229
99MP0006054_spinal_hemorrhage0.78136866
100MP0002163_abnormal_gland_morphology0.76415939
101MP0005384_cellular_phenotype0.76041060
102MP0006035_abnormal_mitochondrial_morpho0.75811123
103MP0005389_reproductive_system_phenotype0.75423228
104MP0002452_abnormal_antigen_presenting0.75381230
105MP0003221_abnormal_cardiomyocyte_apopto0.75338028
106MP0002405_respiratory_system_inflammati0.74687059
107MP0000858_altered_metastatic_potential0.74523821
108MP0008995_early_reproductive_senescence0.74443983
109MP0003861_abnormal_nervous_system0.73564835
110MP0006036_abnormal_mitochondrial_physio0.72416988
111MP0005253_abnormal_eye_physiology0.72209475
112MP0002723_abnormal_immune_serum0.72150827
113MP0002090_abnormal_vision0.72009763
114MP0000653_abnormal_sex_gland0.71674752
115MP0000049_abnormal_middle_ear0.71356971
116MP0009785_altered_susceptibility_to0.71249346
117MP0003866_abnormal_defecation0.70882942
118MP0000428_abnormal_craniofacial_morphol0.70244263
119MP0001853_heart_inflammation0.69760387
120MP0008789_abnormal_olfactory_epithelium0.69419694
121MP0003698_abnormal_male_reproductive0.68584521
122MP0003890_abnormal_embryonic-extraembry0.68084374
123MP0000477_abnormal_intestine_morphology0.66741079
124MP0000537_abnormal_urethra_morphology0.66581395
125MP0009379_abnormal_foot_pigmentation0.66231452
126MP0003122_maternal_imprinting0.65248393
127MP0010155_abnormal_intestine_physiology0.63683500
128MP0000015_abnormal_ear_pigmentation0.62139976
129MP0005408_hypopigmentation0.62022294
130MP0001915_intracranial_hemorrhage0.61522796
131MP0002166_altered_tumor_susceptibility0.61404424
132MP0000631_abnormal_neuroendocrine_gland0.60937578
133MP0005084_abnormal_gallbladder_morpholo0.59778433
134MP0005395_other_phenotype0.59602246
135MP0001661_extended_life_span0.58220426
136MP0001299_abnormal_eye_distance/0.58106438
137MP0003936_abnormal_reproductive_system0.57253080
138MP0001881_abnormal_mammary_gland0.57154310
139MP0005367_renal/urinary_system_phenotyp0.56849376
140MP0000516_abnormal_urinary_system0.56849376
141MP0002161_abnormal_fertility/fecundity0.56158685

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the anterior horn cell (HP:0006802)4.46708551
2Degeneration of anterior horn cells (HP:0002398)4.46708551
3Reticulocytopenia (HP:0001896)4.29825369
4Birth length less than 3rd percentile (HP:0003561)4.10621140
5Abnormality of the labia minora (HP:0012880)4.09441201
6Aplastic anemia (HP:0001915)3.58502202
7Acute encephalopathy (HP:0006846)3.43907675
8Cerebral hypomyelination (HP:0006808)3.43193734
9Oral leukoplakia (HP:0002745)3.40496075
10Colon cancer (HP:0003003)3.35043413
11Thrombocytosis (HP:0001894)3.31323024
12Acute necrotizing encephalopathy (HP:0006965)3.30385515
13Abnormality of cells of the erythroid lineage (HP:0012130)3.27077297
14Abnormal number of erythroid precursors (HP:0012131)3.24532225
15Agnosia (HP:0010524)3.20277404
16Medulloblastoma (HP:0002885)3.08739220
17Selective tooth agenesis (HP:0001592)3.05707226
18Microretrognathia (HP:0000308)2.99694441
19Nephroblastoma (Wilms tumor) (HP:0002667)2.90874110
20Abnormal mitochondria in muscle tissue (HP:0008316)2.86590877
21Breast hypoplasia (HP:0003187)2.86021947
22Aplasia/Hypoplasia of the patella (HP:0006498)2.85394599
23Increased hepatocellular lipid droplets (HP:0006565)2.83360765
24IgM deficiency (HP:0002850)2.82611657
25Ependymoma (HP:0002888)2.79810743
26Patellar aplasia (HP:0006443)2.77911461
27Embryonal renal neoplasm (HP:0011794)2.77778900
28Abnormality of the duodenum (HP:0002246)2.76388120
29Rough bone trabeculation (HP:0100670)2.71881061
30Carpal bone hypoplasia (HP:0001498)2.70985645
31Premature graying of hair (HP:0002216)2.70116087
32Atrophy/Degeneration involving motor neurons (HP:0007373)2.62538170
33Progressive macrocephaly (HP:0004481)2.62029836
34Rhabdomyosarcoma (HP:0002859)2.61181349
3511 pairs of ribs (HP:0000878)2.60379326
36Mitochondrial inheritance (HP:0001427)2.57895101
37Lipid accumulation in hepatocytes (HP:0006561)2.55655954
38Macrocytic anemia (HP:0001972)2.54495907
39Abnormality of chromosome stability (HP:0003220)2.53705647
40Secondary amenorrhea (HP:0000869)2.51507694
41Cerebral edema (HP:0002181)2.50391582
42Myelodysplasia (HP:0002863)2.49402239
43Chromsome breakage (HP:0040012)2.46269094
44Amaurosis fugax (HP:0100576)2.42855141
45Bone marrow hypocellularity (HP:0005528)2.42560055
46Abnormality of methionine metabolism (HP:0010901)2.36607394
47Type I transferrin isoform profile (HP:0003642)2.36427513
48Absent thumb (HP:0009777)2.35931433
49Lymphoma (HP:0002665)2.33791127
50Abnormality of the preputium (HP:0100587)2.32892876
51Cellular immunodeficiency (HP:0005374)2.32217343
52Optic nerve coloboma (HP:0000588)2.30377973
53Pancytopenia (HP:0001876)2.27795826
54Increased serum lactate (HP:0002151)2.27353241
55Impulsivity (HP:0100710)2.27226149
56Hyperglycinemia (HP:0002154)2.27022844
57Pallor (HP:0000980)2.26011666
58Abnormal lung lobation (HP:0002101)2.25572859
59Meckel diverticulum (HP:0002245)2.25416369
60Abnormality of the carotid arteries (HP:0005344)2.24789393
61Abnormality of the ileum (HP:0001549)2.24433135
62Bifid tongue (HP:0010297)2.22716659
63Increased serum pyruvate (HP:0003542)2.21933768
64Abnormality of glycolysis (HP:0004366)2.21933768
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17930434
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17679685
67Basal cell carcinoma (HP:0002671)2.17326016
68Neoplasm of the pancreas (HP:0002894)2.17146831
69Intestinal atresia (HP:0011100)2.16919815
70Hepatocellular necrosis (HP:0001404)2.15543825
71Abnormality of serum amino acid levels (HP:0003112)2.15259769
72Gonadotropin excess (HP:0000837)2.14668521
73Volvulus (HP:0002580)2.13945353
74Cortical dysplasia (HP:0002539)2.13652841
75Septo-optic dysplasia (HP:0100842)2.11362697
763-Methylglutaconic aciduria (HP:0003535)2.11290553
77Sloping forehead (HP:0000340)2.10480910
78Increased nuchal translucency (HP:0010880)2.05456899
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05220395
80Absent radius (HP:0003974)2.03756626
81Clubbing of toes (HP:0100760)2.03069886
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03000814
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03000814
84Neoplasm of the adrenal gland (HP:0100631)2.02793872
85IgG deficiency (HP:0004315)2.02057550
86CNS hypomyelination (HP:0003429)2.01901806
87Horseshoe kidney (HP:0000085)1.99146068
88Muscle fiber atrophy (HP:0100295)1.98892597
89Abnormality of DNA repair (HP:0003254)1.98736062
90Proximal placement of thumb (HP:0009623)1.98127819
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97684091
92Small intestinal stenosis (HP:0012848)1.97344410
93Duodenal stenosis (HP:0100867)1.97344410
94Pancreatic islet-cell hyperplasia (HP:0004510)1.96953714
95Ectopic kidney (HP:0000086)1.96878754
96Abnormal number of incisors (HP:0011064)1.95623091
97Premature ovarian failure (HP:0008209)1.95128169
98Megaloblastic anemia (HP:0001889)1.94850965
99Glioma (HP:0009733)1.94408032
100Hepatic necrosis (HP:0002605)1.93456603
101Triphalangeal thumb (HP:0001199)1.93061365
102Aplasia/Hypoplasia of the sternum (HP:0006714)1.93018764
103Abnormal trabecular bone morphology (HP:0100671)1.92709091
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.91976044
105Stenosis of the external auditory canal (HP:0000402)1.90939851
106Absent forearm bone (HP:0003953)1.90123364
107Aplasia involving forearm bones (HP:0009822)1.90123364
108Trismus (HP:0000211)1.88418810
109Choanal atresia (HP:0000453)1.88410326
110Lactic acidosis (HP:0003128)1.87806266
111Atresia of the external auditory canal (HP:0000413)1.87023239
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86777056
113Hypoplasia of the radius (HP:0002984)1.86697008
114Type 2 muscle fiber atrophy (HP:0003554)1.86695855
115Oligodactyly (hands) (HP:0001180)1.86569521
116Abnormality of T cells (HP:0002843)1.83188530
117Deviation of the thumb (HP:0009603)1.83015068
118Poikiloderma (HP:0001029)1.82992871
119Abnormality of serine family amino acid metabolism (HP:0010894)1.82573498
120Abnormality of glycine metabolism (HP:0010895)1.82573498
121Methylmalonic acidemia (HP:0002912)1.81914697
122Pulmonary fibrosis (HP:0002206)1.80935065
123Neoplasm of the colon (HP:0100273)1.80904921
124Multiple enchondromatosis (HP:0005701)1.80504597
125Leukodystrophy (HP:0002415)1.80500128
126Supernumerary spleens (HP:0009799)1.80113843
127Abnormality of T cell physiology (HP:0011840)1.79807445
128Severe visual impairment (HP:0001141)1.79457146
129Increased CSF lactate (HP:0002490)1.77920141
130Renal Fanconi syndrome (HP:0001994)1.76954529
131Absent septum pellucidum (HP:0001331)1.76774239
132Neoplasm of the adrenal cortex (HP:0100641)1.76434691
133Hyperglycinuria (HP:0003108)1.75787668
134Median cleft lip (HP:0000161)1.75312484
135Respiratory difficulties (HP:0002880)1.74174104
136Hypoplastic pelvis (HP:0008839)1.73743886
137Abnormal protein glycosylation (HP:0012346)1.73069488
138Abnormal glycosylation (HP:0012345)1.73069488
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73069488
140Abnormal protein N-linked glycosylation (HP:0012347)1.73069488
141Postnatal microcephaly (HP:0005484)1.72182986
142Microvesicular hepatic steatosis (HP:0001414)1.72082287
143Prominent metopic ridge (HP:0005487)1.71102787
144Abnormality of the septum pellucidum (HP:0007375)1.69909786
145Facial cleft (HP:0002006)1.69509071
146Abnormality of the metopic suture (HP:0005556)1.68190101
147Embryonal neoplasm (HP:0002898)1.67795062
148Ovarian neoplasm (HP:0100615)1.66870462
149Gastrointestinal atresia (HP:0002589)1.66603040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.19635340
2WEE13.87529810
3EIF2AK13.34570837
4CDC73.29505366
5VRK22.94403541
6TSSK62.86925617
7PBK2.83479358
8STK162.82395963
9PASK2.76051854
10SRPK12.74884674
11TRIM282.65463648
12ACVR1B2.48721441
13TLK12.37299290
14NEK22.28702806
15NUAK12.27200484
16EIF2AK32.19393115
17MKNK12.12884465
18NME21.94074699
19MAP4K11.93234633
20TAF11.92439732
21MST41.91696285
22TGFBR11.89955735
23BRSK21.82700302
24ATR1.75968972
25VRK11.64265537
26PLK11.62502091
27MKNK21.56673674
28TTK1.51785457
29NEK11.51098667
30WNK31.50598672
31CCNB11.46588031
32PLK41.46510306
33AURKB1.41038100
34CDK81.39948695
35TESK21.37449733
36CDK71.33860889
37DYRK31.32722205
38RPS6KB21.31614278
39TXK1.28432639
40PLK31.26715011
41RPS6KA41.19267573
42MAP4K21.18519375
43CDK41.16191368
44BCR1.15836379
45BRSK11.14316113
46AURKA1.11997130
47CHEK21.09171028
48BCKDK1.07089271
49BTK1.06244093
50TEC1.04421039
51ZAK1.03527760
52ZAP701.02848878
53TNIK0.99974264
54PLK20.99813665
55PNCK0.99266178
56STK100.98308492
57FLT30.98279903
58PAK40.97367504
59KDR0.95956463
60PDK20.95217043
61CHEK10.94237214
62CLK10.89459319
63MAP3K80.87973441
64EEF2K0.87097667
65SIK30.81376487
66CSNK1A1L0.80859555
67STK40.80642780
68CSNK1G20.78542822
69DYRK20.73938441
70EIF2AK20.73676497
71NEK90.73634952
72DAPK10.73633810
73ATM0.70844809
74CSNK2A20.69905215
75CSNK2A10.68423311
76MAPKAPK30.68174155
77CDK20.67337550
78STK30.62776726
79TESK10.62609228
80MAP3K100.61646156
81CSF1R0.60660341
82MAP3K120.60359432
83STK38L0.60098522
84IRAK40.58436865
85JAK30.56757774
86NLK0.55376657
87KIT0.55016778
88BRAF0.53683196
89PIM10.53416998
90LRRK20.52588146
91CDK120.52502639
92SCYL20.51395568
93TAOK20.51356494
94MAP3K40.50939053
95CSNK1G30.49086609
96CDK10.48528629
97CSNK1E0.48054926
98MELK0.47053234
99CDK190.44475728
100ERBB40.44113663
101PAK10.42993139
102GRK60.42594433
103ERBB30.42319768
104BLK0.41462802
105ALK0.41060616
106PRKDC0.40884896
107SMG10.39921622
108MAPKAPK50.39283585
109ILK0.39245970
110MINK10.38879801
111CSNK1G10.38425341
112LYN0.38403554
113YES10.38187023
114FGFR10.36464462
115RPS6KA50.35937847
116CDK30.35443575
117EPHA20.34514266
118NME10.34443602
119LCK0.34322283
120SYK0.34105538
121BMPR1B0.32298529
122BRD40.31183365
123PRKCI0.31145465
124MAP2K60.31097458
125CDK60.30747784
126ITK0.30368162
127PIM20.30123364
128STK240.27708072
129OXSR10.27122898
130AKT20.26378082
131MAP2K70.25926899
132CDK180.25361946
133CDK90.24972931
134MAP3K50.22247303
135CDK140.19766076
136CDK11A0.19155509

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.04223848
2Mismatch repair_Homo sapiens_hsa034304.32333642
3Proteasome_Homo sapiens_hsa030503.62342329
4Ribosome_Homo sapiens_hsa030103.54832343
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35131641
6Base excision repair_Homo sapiens_hsa034103.32021123
7Spliceosome_Homo sapiens_hsa030403.31467917
8RNA polymerase_Homo sapiens_hsa030203.26237472
9Homologous recombination_Homo sapiens_hsa034402.95896791
10Nucleotide excision repair_Homo sapiens_hsa034202.89265430
11RNA transport_Homo sapiens_hsa030132.81914788
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.73563318
13Pyrimidine metabolism_Homo sapiens_hsa002402.51041380
14Cell cycle_Homo sapiens_hsa041102.45215518
15One carbon pool by folate_Homo sapiens_hsa006702.44800426
16Non-homologous end-joining_Homo sapiens_hsa034502.25929858
17Basal transcription factors_Homo sapiens_hsa030222.03152709
18RNA degradation_Homo sapiens_hsa030181.96748860
19Fanconi anemia pathway_Homo sapiens_hsa034601.91682376
20Propanoate metabolism_Homo sapiens_hsa006401.82297228
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73828296
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59178988
23Steroid biosynthesis_Homo sapiens_hsa001001.47675163
24* mRNA surveillance pathway_Homo sapiens_hsa030151.46330371
25Purine metabolism_Homo sapiens_hsa002301.45061814
26Fatty acid elongation_Homo sapiens_hsa000621.40582211
27Protein export_Homo sapiens_hsa030601.37814496
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30933314
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25073638
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21269311
31Antigen processing and presentation_Homo sapiens_hsa046121.19560323
32Pentose phosphate pathway_Homo sapiens_hsa000301.15677019
33p53 signaling pathway_Homo sapiens_hsa041151.13853972
34Herpes simplex infection_Homo sapiens_hsa051681.04362472
35Primary immunodeficiency_Homo sapiens_hsa053401.04205606
36Biosynthesis of amino acids_Homo sapiens_hsa012301.01136068
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00244704
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.99710442
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97240823
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.96114383
41Alzheimers disease_Homo sapiens_hsa050100.85244696
42Systemic lupus erythematosus_Homo sapiens_hsa053220.85047578
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.82365278
44Selenocompound metabolism_Homo sapiens_hsa004500.79984443
45Viral carcinogenesis_Homo sapiens_hsa052030.78905333
46Carbon metabolism_Homo sapiens_hsa012000.77311615
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75014303
48Fatty acid metabolism_Homo sapiens_hsa012120.73505028
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72724235
50Vitamin B6 metabolism_Homo sapiens_hsa007500.72401312
51Glutathione metabolism_Homo sapiens_hsa004800.71411711
52Butanoate metabolism_Homo sapiens_hsa006500.69720999
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67524405
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66486786
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65852436
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65520752
57Folate biosynthesis_Homo sapiens_hsa007900.63729565
58HTLV-I infection_Homo sapiens_hsa051660.61900217
59N-Glycan biosynthesis_Homo sapiens_hsa005100.61515657
60Oocyte meiosis_Homo sapiens_hsa041140.59869696
61Sulfur relay system_Homo sapiens_hsa041220.59845489
62Fructose and mannose metabolism_Homo sapiens_hsa000510.59307210
63Parkinsons disease_Homo sapiens_hsa050120.58378356
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58102933
65Legionellosis_Homo sapiens_hsa051340.57383652
66Huntingtons disease_Homo sapiens_hsa050160.56753787
67Peroxisome_Homo sapiens_hsa041460.55085837
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54977964
69Measles_Homo sapiens_hsa051620.54724661
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51502665
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44413863
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44108349
73Notch signaling pathway_Homo sapiens_hsa043300.43982049
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43667796
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42329333
76Fatty acid degradation_Homo sapiens_hsa000710.41359535
77Galactose metabolism_Homo sapiens_hsa000520.37964879
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37354827
79Thyroid cancer_Homo sapiens_hsa052160.35039990
80Wnt signaling pathway_Homo sapiens_hsa043100.34613739
81Hedgehog signaling pathway_Homo sapiens_hsa043400.33847728
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33710737
83Arginine and proline metabolism_Homo sapiens_hsa003300.33078974
84Metabolic pathways_Homo sapiens_hsa011000.32978738
85Shigellosis_Homo sapiens_hsa051310.32729952
86beta-Alanine metabolism_Homo sapiens_hsa004100.31862571
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31602549
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.31233381
89Apoptosis_Homo sapiens_hsa042100.31197852
90TGF-beta signaling pathway_Homo sapiens_hsa043500.30227799
91Lysine degradation_Homo sapiens_hsa003100.29831917
92Oxidative phosphorylation_Homo sapiens_hsa001900.29338898
93Viral myocarditis_Homo sapiens_hsa054160.27237179
94Alcoholism_Homo sapiens_hsa050340.26436740
95Hepatitis B_Homo sapiens_hsa051610.25279350
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24110789
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.23174488
98Hematopoietic cell lineage_Homo sapiens_hsa046400.21932081
99Pyruvate metabolism_Homo sapiens_hsa006200.21750608
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21657871
101Cardiac muscle contraction_Homo sapiens_hsa042600.21580601
102Influenza A_Homo sapiens_hsa051640.20971214
103MicroRNAs in cancer_Homo sapiens_hsa052060.20527511
104Other glycan degradation_Homo sapiens_hsa005110.20110777
105Regulation of autophagy_Homo sapiens_hsa041400.19507050
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18676812
107Small cell lung cancer_Homo sapiens_hsa052220.15759281
108Vitamin digestion and absorption_Homo sapiens_hsa049770.15701910
109Tryptophan metabolism_Homo sapiens_hsa003800.15049676
110Colorectal cancer_Homo sapiens_hsa052100.14593617
111Phototransduction_Homo sapiens_hsa047440.14036883
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13639699
113Sulfur metabolism_Homo sapiens_hsa009200.13571378
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12678620
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.12465103
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12264648
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12085699
118Fat digestion and absorption_Homo sapiens_hsa049750.10907041
119Adherens junction_Homo sapiens_hsa045200.09719781
120Basal cell carcinoma_Homo sapiens_hsa052170.09156749
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09138123
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09100157
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07001198
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06287077
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05505650
126Pathways in cancer_Homo sapiens_hsa052000.05171392
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.05074265
128Hippo signaling pathway_Homo sapiens_hsa043900.05015084
129Arachidonic acid metabolism_Homo sapiens_hsa005900.04804678
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04783049
131Bladder cancer_Homo sapiens_hsa052190.04598733
132T cell receptor signaling pathway_Homo sapiens_hsa046600.04435694
133Chemical carcinogenesis_Homo sapiens_hsa052040.03183849

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