CPLX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.82472100
2positive regulation of guanylate cyclase activity (GO:0031284)9.54702940
3phototransduction (GO:0007602)9.37931919
4phototransduction, visible light (GO:0007603)9.37815825
5detection of visible light (GO:0009584)9.30913915
6GMP metabolic process (GO:0046037)9.22632163
7detection of light stimulus (GO:0009583)9.18705706
8regulation of guanylate cyclase activity (GO:0031282)8.62161848
9protein-chromophore linkage (GO:0018298)8.47618452
10visual perception (GO:0007601)8.16184176
11sensory perception of light stimulus (GO:0050953)8.08826923
12cellular response to light stimulus (GO:0071482)7.11184028
13photoreceptor cell differentiation (GO:0046530)6.70402561
14eye photoreceptor cell differentiation (GO:0001754)6.70402561
15regulation of cGMP metabolic process (GO:0030823)6.49290691
16detection of external stimulus (GO:0009581)6.44596949
17detection of abiotic stimulus (GO:0009582)6.32478630
18retina development in camera-type eye (GO:0060041)6.24380008
19positive regulation of cGMP biosynthetic process (GO:0030828)6.20562241
20regulation of cGMP biosynthetic process (GO:0030826)5.82572724
21positive regulation of cGMP metabolic process (GO:0030825)5.46940179
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.28038276
23nonmotile primary cilium assembly (GO:0035058)5.20727258
24receptor guanylyl cyclase signaling pathway (GO:0007168)4.61367751
25cellular response to radiation (GO:0071478)4.55586768
26detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.50962717
27centriole replication (GO:0007099)4.36504420
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.36462438
29piRNA metabolic process (GO:0034587)4.31641740
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.30254336
31regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.13802844
32regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.07117635
33regulation of voltage-gated calcium channel activity (GO:1901385)4.04937845
34adaptation of signaling pathway (GO:0023058)3.99891968
35regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.94797295
36positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.94797295
37cell morphogenesis involved in neuron differentiation (GO:0048667)3.94721173
38regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.91127282
39regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.91127282
40protein localization to synapse (GO:0035418)3.89162928
41cornea development in camera-type eye (GO:0061303)3.88279116
42sensory perception (GO:0007600)3.87872557
43sodium ion export (GO:0071436)3.87394681
44protein prenylation (GO:0018342)3.69267104
45prenylation (GO:0097354)3.69267104
46behavioral response to ethanol (GO:0048149)3.66333310
47neuron development (GO:0048666)3.63723096
48response to light stimulus (GO:0009416)3.63600868
49regulation of cilium movement (GO:0003352)3.61915049
50peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.59987518
51inositol phosphate catabolic process (GO:0071545)3.55383814
52regulation of meiosis I (GO:0060631)3.54102461
53response to histamine (GO:0034776)3.48708371
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46832175
55platelet dense granule organization (GO:0060155)3.44114863
56epithelial cilium movement (GO:0003351)3.39018708
57behavioral response to nicotine (GO:0035095)3.38955271
58L-fucose metabolic process (GO:0042354)3.36844920
59L-fucose catabolic process (GO:0042355)3.36844920
60fucose catabolic process (GO:0019317)3.36844920
61regulation of clathrin-mediated endocytosis (GO:2000369)3.32176590
62cellular potassium ion homeostasis (GO:0030007)3.27748543
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26669941
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26422811
65negative regulation of receptor-mediated endocytosis (GO:0048261)3.23459383
66positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.23057948
67positive regulation of sodium ion transmembrane transport (GO:1902307)3.19062476
68neural tube formation (GO:0001841)3.18482217
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15700802
70membrane hyperpolarization (GO:0060081)3.14151976
71regulation of short-term neuronal synaptic plasticity (GO:0048172)3.11057331
72retina layer formation (GO:0010842)3.10950521
73phosphorylated carbohydrate dephosphorylation (GO:0046838)3.08257985
74inositol phosphate dephosphorylation (GO:0046855)3.08257985
75multicellular organism reproduction (GO:0032504)3.06634306
76DNA methylation involved in gamete generation (GO:0043046)3.06481619
77polyol catabolic process (GO:0046174)3.06197609
78proline transport (GO:0015824)3.05212950
79short-term memory (GO:0007614)3.02169675
80male meiosis I (GO:0007141)3.01981634
81regulation of MHC class II biosynthetic process (GO:0045346)3.01304562
82limb bud formation (GO:0060174)2.99484516
83male meiosis (GO:0007140)2.97403096
84retina homeostasis (GO:0001895)2.96749920
85estrogen biosynthetic process (GO:0006703)2.96122239
86synaptic vesicle maturation (GO:0016188)2.93917833
87regulation of sarcomere organization (GO:0060297)2.93192577
88cilium or flagellum-dependent cell motility (GO:0001539)2.92845279
89response to pheromone (GO:0019236)2.92498185
90chemosensory behavior (GO:0007635)2.92392874
91regulation of penile erection (GO:0060405)2.91432207
92gamma-aminobutyric acid transport (GO:0015812)2.89537052
93DNA double-strand break processing (GO:0000729)2.89470673
94DNA deamination (GO:0045006)2.88530872
95behavioral response to cocaine (GO:0048148)2.88448802
96centriole assembly (GO:0098534)2.87640237
97potassium ion homeostasis (GO:0055075)2.87611219
98positive regulation of neurotransmitter transport (GO:0051590)2.87155564
99replication fork processing (GO:0031297)2.86985377
100synaptic transmission, dopaminergic (GO:0001963)2.86263439
101regulation of cytokine production involved in inflammatory response (GO:1900015)2.84869197
102regulation of timing of cell differentiation (GO:0048505)2.83760962
103CDP-diacylglycerol biosynthetic process (GO:0016024)2.81937426
104indolalkylamine metabolic process (GO:0006586)2.81144307
105cilium movement (GO:0003341)2.80695926
106protein K11-linked deubiquitination (GO:0035871)2.78997119
107synaptic vesicle exocytosis (GO:0016079)2.77383252
108auditory receptor cell stereocilium organization (GO:0060088)2.76349338
109protein localization to cilium (GO:0061512)2.72834621
110positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.72832260
111regulation of neurotransmitter uptake (GO:0051580)2.72576437
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71184846
113negative regulation of neurological system process (GO:0031645)2.71142852
114detection of chemical stimulus involved in sensory perception (GO:0050907)2.70037961
115glycosphingolipid biosynthetic process (GO:0006688)2.69098203
116somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65855404
117somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65855404
118isotype switching (GO:0045190)2.65855404
119reciprocal meiotic recombination (GO:0007131)2.64715748
120reciprocal DNA recombination (GO:0035825)2.64715748
121double-strand break repair via homologous recombination (GO:0000724)2.64711488
122recombinational repair (GO:0000725)2.64401836
123striatum development (GO:0021756)2.62413731
124protein polyglutamylation (GO:0018095)2.62271226
125cellular ketone body metabolic process (GO:0046950)2.61545107
126regulation of development, heterochronic (GO:0040034)2.61491041
127CDP-diacylglycerol metabolic process (GO:0046341)2.61007382
128negative regulation of cation channel activity (GO:2001258)2.60119161
129positive regulation of cyclase activity (GO:0031281)2.59591752
130peptidyl-histidine modification (GO:0018202)2.59587652
131regulation of interleukin-6 biosynthetic process (GO:0045408)2.58856531
132dopamine receptor signaling pathway (GO:0007212)2.57880821
133negative regulation of calcium ion transmembrane transport (GO:1903170)2.57547225
134negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.57547225
135preassembly of GPI anchor in ER membrane (GO:0016254)2.57278388
136anterograde synaptic vesicle transport (GO:0048490)2.56806432
137synapsis (GO:0007129)2.56510358
138nucleotide transmembrane transport (GO:1901679)2.55744408
139positive regulation of osteoclast differentiation (GO:0045672)2.55330934
140proteasome assembly (GO:0043248)2.55249059
141positive regulation of histone H3-K4 methylation (GO:0051571)2.55153087
142positive regulation of interleukin-1 beta secretion (GO:0050718)2.54520679
143detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.54465855
144axoneme assembly (GO:0035082)2.54269074
145cilium organization (GO:0044782)2.53363357
146icosanoid secretion (GO:0032309)2.53171838
147arachidonic acid secretion (GO:0050482)2.53171838
148negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52561967
149microtubule nucleation (GO:0007020)2.52075852
150startle response (GO:0001964)2.49942223
151relaxation of smooth muscle (GO:0044557)2.48860071
152response to radiation (GO:0009314)2.48090952
153regulation of hexokinase activity (GO:1903299)2.48036762
154regulation of glucokinase activity (GO:0033131)2.48036762
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47494854
156cellular sodium ion homeostasis (GO:0006883)2.47334144
157mitochondrion transport along microtubule (GO:0047497)2.46979953
158establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.46979953
159positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.46607567
160synaptic vesicle endocytosis (GO:0048488)2.46547078
161inner ear receptor stereocilium organization (GO:0060122)2.46482974
162synaptic vesicle docking involved in exocytosis (GO:0016081)2.45276854
163cilium assembly (GO:0042384)2.44972833
164water-soluble vitamin biosynthetic process (GO:0042364)2.44393127
165cilium morphogenesis (GO:0060271)2.44212309
166ketone body metabolic process (GO:1902224)2.42047773
167tachykinin receptor signaling pathway (GO:0007217)2.42038789
168establishment of protein localization to Golgi (GO:0072600)2.41465869
169negative regulation of DNA-dependent DNA replication (GO:2000104)2.41296684
170regulation of collateral sprouting (GO:0048670)2.40954962
171positive regulation of interleukin-1 secretion (GO:0050716)2.40199727
172sperm motility (GO:0030317)2.39501572
173mannosylation (GO:0097502)2.37577314
174reflex (GO:0060004)2.35969366
175regulation of rhodopsin mediated signaling pathway (GO:0022400)16.8649292
176rhodopsin mediated signaling pathway (GO:0016056)16.5654460
177retinal cone cell development (GO:0046549)15.2258395
178detection of light stimulus involved in sensory perception (GO:0050962)11.9803217
179detection of light stimulus involved in visual perception (GO:0050908)11.9803217
180photoreceptor cell development (GO:0042461)11.8309846
181eye photoreceptor cell development (GO:0042462)11.5015643
182photoreceptor cell maintenance (GO:0045494)11.0333787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.92510754
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.78272623
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.76623935
4ZNF274_21170338_ChIP-Seq_K562_Hela3.48576311
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28701125
6GBX2_23144817_ChIP-Seq_PC3_Human3.14612223
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65835264
8DROSHA_22980978_ChIP-Seq_HELA_Human2.65329471
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.57667641
10VDR_22108803_ChIP-Seq_LS180_Human2.53913581
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.50772802
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.49787933
13EZH2_22144423_ChIP-Seq_EOC_Human2.36428593
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.28211442
15AR_21572438_ChIP-Seq_LNCaP_Human2.19943853
16REST_21632747_ChIP-Seq_MESCs_Mouse2.10175900
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08287688
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03908315
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02756933
20P53_22127205_ChIP-Seq_FIBROBLAST_Human1.97119653
21EWS_26573619_Chip-Seq_HEK293_Human1.96656895
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95686649
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.95173265
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95064403
25IGF1R_20145208_ChIP-Seq_DFB_Human1.85687150
26SMAD3_21741376_ChIP-Seq_HESCs_Human1.84015923
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82348831
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80893534
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80402108
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80395507
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80243809
32TAF15_26573619_Chip-Seq_HEK293_Human1.79783176
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.79215575
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76587058
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70344186
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.69904796
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67078129
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65470091
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64032016
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62979274
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59931984
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59884699
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.57073533
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56147786
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55066107
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.54999185
47* AR_19668381_ChIP-Seq_PC3_Human1.53244341
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.52232844
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51588918
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51347732
51* CBP_20019798_ChIP-Seq_JUKART_Human1.50160844
52* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50160844
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49472650
54SMAD4_21799915_ChIP-Seq_A2780_Human1.48899125
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48235605
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.48000560
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43841681
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43458905
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.43011428
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42743704
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41856777
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40108857
63TP53_22573176_ChIP-Seq_HFKS_Human1.39841685
64SOX2_19829295_ChIP-Seq_ESCs_Human1.39478771
65NANOG_19829295_ChIP-Seq_ESCs_Human1.39478771
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39408596
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37467610
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.35463089
69TCF4_22108803_ChIP-Seq_LS180_Human1.35261566
70AR_25329375_ChIP-Seq_VCAP_Human1.34859936
71* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.33563309
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32398767
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32146506
74IRF1_19129219_ChIP-ChIP_H3396_Human1.31659418
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31179715
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31179715
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30608024
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.29629341
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29351146
80ELK4_26923725_Chip-Seq_MESODERM_Mouse1.28308855
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28024369
82KDM2B_26808549_Chip-Seq_K562_Human1.27937266
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.26701570
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26088709
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25731579
86RUNX2_22187159_ChIP-Seq_PCA_Human1.24507593
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22218525
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.20681021
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20352094
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20352094
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.20235657
92CBP_21632823_ChIP-Seq_H3396_Human1.20072567
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19353871
94STAT3_23295773_ChIP-Seq_U87_Human1.19281309
95WDR5_24793694_ChIP-Seq_LNCAP_Human1.18956819
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.18357613
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17752475
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17544125
99P53_22387025_ChIP-Seq_ESCs_Mouse1.16491638
100TBL1_22424771_ChIP-Seq_293T_Human1.16450371
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16061545
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.15391610
103SMC4_20622854_ChIP-Seq_HELA_Human1.14622042
104P300_19829295_ChIP-Seq_ESCs_Human1.14232535
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.14169717
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13816211
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13616023
108GABP_17652178_ChIP-ChIP_JURKAT_Human1.12944304
109* MYC_18940864_ChIP-ChIP_HL60_Human1.12500279
110CTCF_27219007_Chip-Seq_Bcells_Human1.12427799
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12161057
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.12052259
113ELK1_19687146_ChIP-ChIP_HELA_Human1.11989905
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11499312
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.11499312
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.10748364
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.10667575
118AR_20517297_ChIP-Seq_VCAP_Human1.09225888
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06771713
120BCAT_22108803_ChIP-Seq_LS180_Human1.06671270
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06245718
122CDX2_22108803_ChIP-Seq_LS180_Human1.05843608
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05790776
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05707869
125CMYC_18555785_Chip-Seq_ESCs_Mouse1.04711640
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03940489
127P300_18555785_Chip-Seq_ESCs_Mouse1.03879960
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02845129
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.02671340
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02431666
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02119425
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01940614
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01567952
134EGR1_19032775_ChIP-ChIP_M12_Human1.01507713
135SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01394418
136VDR_23849224_ChIP-Seq_CD4+_Human1.01380331
137TCF4_23295773_ChIP-Seq_U87_Human1.01261373
138OCT4_18555785_Chip-Seq_ESCs_Mouse1.01015005
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00241864
140SOX2_18555785_Chip-Seq_ESCs_Mouse1.00079757
141EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00050784
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99561060
143TCF4_18268006_ChIP-ChIP_LS174T_Human0.98563800
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98157731
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97888828
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97835012
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97824558
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97222950
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.96994705
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.96692642
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.95907892
152FUS_26573619_Chip-Seq_HEK293_Human0.94480134
153P68_20966046_ChIP-Seq_HELA_Human0.94385536
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.94115864
155TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93629464
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91712642
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91407287
158SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91029838
159ER_23166858_ChIP-Seq_MCF-7_Human0.90735654
160VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90255805
161CTCF_20526341_ChIP-Seq_ESCs_Human0.90076274
162SOX2_21211035_ChIP-Seq_LN229_Gbm0.89602668
163* NCOR_22424771_ChIP-Seq_293T_Human0.89376431
164BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88785906
165RNF2_27304074_Chip-Seq_NSC_Mouse0.88484227
166EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86912209
167OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85963252
168TAF2_19829295_ChIP-Seq_ESCs_Human0.85495677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.99161905
2MP0003011_delayed_dark_adaptation9.16568979
3MP0005253_abnormal_eye_physiology6.73536327
4MP0006072_abnormal_retinal_apoptosis6.68463618
5MP0003950_abnormal_plasma_membrane4.46078919
6MP0000569_abnormal_digit_pigmentation4.05827995
7MP0005195_abnormal_posterior_eye4.01589718
8MP0002090_abnormal_vision3.70841402
9MP0008877_abnormal_DNA_methylation3.44735429
10MP0001324_abnormal_eye_pigmentation3.41887002
11MP0005391_vision/eye_phenotype3.23733160
12MP0002638_abnormal_pupillary_reflex3.14977885
13MP0003195_calcinosis2.89943191
14MP0000372_irregular_coat_pigmentation2.89185469
15MP0002229_neurodegeneration2.61548184
16MP0005174_abnormal_tail_pigmentation2.58648420
17MP0008058_abnormal_DNA_repair2.44683828
18MP0005423_abnormal_somatic_nervous2.44382286
19MP0003718_maternal_effect2.32275168
20MP0001764_abnormal_homeostasis2.16490593
21MP0000015_abnormal_ear_pigmentation2.14490443
22MP0004233_abnormal_muscle_weight2.01056082
23MP0002752_abnormal_somatic_nervous2.00622276
24MP0003787_abnormal_imprinting1.97340349
25MP0005645_abnormal_hypothalamus_physiol1.90635801
26MP0000427_abnormal_hair_cycle1.87454931
27MP0001984_abnormal_olfaction1.83399980
28MP0002102_abnormal_ear_morphology1.77446453
29MP0002876_abnormal_thyroid_physiology1.76562557
30MP0008872_abnormal_physiological_respon1.73080907
31MP0002095_abnormal_skin_pigmentation1.65462394
32MP0001986_abnormal_taste_sensitivity1.65087443
33MP0002736_abnormal_nociception_after1.57481337
34MP0001502_abnormal_circadian_rhythm1.56144395
35MP0005083_abnormal_biliary_tract1.48693234
36MP0008995_early_reproductive_senescence1.47508530
37MP0002882_abnormal_neuron_morphology1.45397869
38MP0008875_abnormal_xenobiotic_pharmacok1.41853585
39MP0002653_abnormal_ependyma_morphology1.37367780
40MP0006276_abnormal_autonomic_nervous1.35991800
41MP0002938_white_spotting1.34865398
42MP0005171_absent_coat_pigmentation1.26045478
43MP0005085_abnormal_gallbladder_physiolo1.23231353
44MP0002837_dystrophic_cardiac_calcinosis1.23197085
45MP0001873_stomach_inflammation1.21655344
46MP0005410_abnormal_fertilization1.16031765
47MP0004019_abnormal_vitamin_homeostasis1.15377846
48MP0003186_abnormal_redox_activity1.14121687
49MP0002332_abnormal_exercise_endurance1.12567137
50MP0004782_abnormal_surfactant_physiolog1.07359309
51MP0002751_abnormal_autonomic_nervous1.06600901
52MP0005310_abnormal_salivary_gland1.03439028
53MP0001929_abnormal_gametogenesis1.01713884
54MP0000647_abnormal_sebaceous_gland1.00391134
55MP0005395_other_phenotype0.98550153
56MP0001529_abnormal_vocalization0.98253611
57MP0001486_abnormal_startle_reflex0.97590878
58MP0005084_abnormal_gallbladder_morpholo0.96869364
59MP0006292_abnormal_olfactory_placode0.96856779
60MP0003121_genomic_imprinting0.96462754
61MP0002254_reproductive_system_inflammat0.94938035
62MP0005499_abnormal_olfactory_system0.93277752
63MP0005394_taste/olfaction_phenotype0.93277752
64MP0005197_abnormal_uvea_morphology0.92827137
65MP0003136_yellow_coat_color0.92021549
66MP0004885_abnormal_endolymph0.89772651
67MP0002160_abnormal_reproductive_system0.89698269
68MP0005367_renal/urinary_system_phenotyp0.88209612
69MP0000516_abnormal_urinary_system0.88209612
70MP0000653_abnormal_sex_gland0.86254334
71MP0003634_abnormal_glial_cell0.85775209
72MP0002210_abnormal_sex_determination0.85362593
73MP0002272_abnormal_nervous_system0.82726081
74MP0003786_premature_aging0.82416871
75MP0005075_abnormal_melanosome_morpholog0.82175180
76MP0008789_abnormal_olfactory_epithelium0.81264810
77MP0004147_increased_porphyrin_level0.80930934
78MP0000383_abnormal_hair_follicle0.77785530
79MP0002127_abnormal_cardiovascular_syste0.77343597
80MP0000778_abnormal_nervous_system0.77298708
81MP0000371_diluted_coat_color0.76714827
82MP0010094_abnormal_chromosome_stability0.76429145
83MP0005187_abnormal_penis_morphology0.76200561
84MP0001905_abnormal_dopamine_level0.73835335
85MP0003646_muscle_fatigue0.72602324
86MP0004270_analgesia0.70888262
87MP0004215_abnormal_myocardial_fiber0.70143809
88MP0003880_abnormal_central_pattern0.70025957
89MP0009046_muscle_twitch0.68740092
90MP0002064_seizures0.67494401
91MP0002734_abnormal_mechanical_nocicepti0.66900293
92MP0003635_abnormal_synaptic_transmissio0.63410601
93MP0005248_abnormal_Harderian_gland0.61032944
94MP0002067_abnormal_sensory_capabilities0.60755017
95MP0004145_abnormal_muscle_electrophysio0.58433789
96MP0001963_abnormal_hearing_physiology0.56734162
97MP0002063_abnormal_learning/memory/cond0.55722407
98MP0004859_abnormal_synaptic_plasticity0.54742923
99MP0004084_abnormal_cardiac_muscle0.54231006
100MP0005376_homeostasis/metabolism_phenot0.52730433
101MP0008775_abnormal_heart_ventricle0.50772802
102MP0000631_abnormal_neuroendocrine_gland0.50484187
103MP0001286_abnormal_eye_development0.50101723
104MP0002572_abnormal_emotion/affect_behav0.49930424
105MP0004036_abnormal_muscle_relaxation0.47540118
106MP0001968_abnormal_touch/_nociception0.45596831
107MP0010368_abnormal_lymphatic_system0.44861703
108MP0010386_abnormal_urinary_bladder0.44185603
109MP0005595_abnormal_vascular_smooth0.44137955
110MP0010030_abnormal_orbit_morphology0.43095280
111MP0004085_abnormal_heartbeat0.42580476
112MP0009745_abnormal_behavioral_response0.42205835
113MP0005620_abnormal_muscle_contractility0.41510979
114MP0008569_lethality_at_weaning0.40979280
115MP0002184_abnormal_innervation0.40201224
116MP0001188_hyperpigmentation0.38709978
117MP0004924_abnormal_behavior0.38314218
118MP0005386_behavior/neurological_phenoty0.38314218
119MP0008004_abnormal_stomach_pH0.37133091
120MP0003045_fibrosis0.33674119
121MP0000026_abnormal_inner_ear0.33345075
122MP0004742_abnormal_vestibular_system0.33149306
123MP0000465_gastrointestinal_hemorrhage0.33023804
124MP0001346_abnormal_lacrimal_gland0.32833134
125MP0003890_abnormal_embryonic-extraembry0.32774057
126MP0004142_abnormal_muscle_tone0.30603280
127MP0002234_abnormal_pharynx_morphology0.29291294
128MP0004043_abnormal_pH_regulation0.28668660
129MP0002066_abnormal_motor_capabilities/c0.27426148
130MP0001661_extended_life_span0.26877468
131MP0002909_abnormal_adrenal_gland0.26614927
132MP0002152_abnormal_brain_morphology0.26477269
133MP0002928_abnormal_bile_duct0.25201158
134MP0004811_abnormal_neuron_physiology0.25032514
135MP0009780_abnormal_chondrocyte_physiolo0.24272008
136MP0003137_abnormal_impulse_conducting0.24244850
137MP0002697_abnormal_eye_size0.23510892
138MP0005266_abnormal_metabolism0.22230692
139MP0001501_abnormal_sleep_pattern0.21455794
140MP0000751_myopathy0.21057191
141MP0002108_abnormal_muscle_morphology0.19693715
142MP0005670_abnormal_white_adipose0.19443901
143MP0005330_cardiomyopathy0.18993050
144MP0002557_abnormal_social/conspecific_i0.18855233
145MP0003252_abnormal_bile_duct0.18514250
146MP0000749_muscle_degeneration0.18052473
147MP0005646_abnormal_pituitary_gland0.18027528
148MP0002069_abnormal_eating/drinking_beha0.17055634
149MP0005220_abnormal_exocrine_pancreas0.16733940
150MP0005076_abnormal_cell_differentiation0.16650561
151MP0003698_abnormal_male_reproductive0.16418203

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.29441554
2Pigmentary retinal degeneration (HP:0001146)8.66343565
3Chorioretinal atrophy (HP:0000533)8.50933768
4Central scotoma (HP:0000603)8.38207172
5Dyschromatopsia (HP:0007641)8.07676614
6Abnormality of macular pigmentation (HP:0008002)7.94522216
7Attenuation of retinal blood vessels (HP:0007843)7.59679506
8Pendular nystagmus (HP:0012043)7.30325390
9Scotoma (HP:0000575)7.29293704
10Decreased central vision (HP:0007663)6.44276892
11Abolished electroretinogram (ERG) (HP:0000550)6.08581372
12Photophobia (HP:0000613)5.53094997
13Type II diabetes mellitus (HP:0005978)5.47342013
14Severe visual impairment (HP:0001141)5.14476939
15Increased corneal curvature (HP:0100692)4.94354680
16Keratoconus (HP:0000563)4.94354680
17Vitreoretinal degeneration (HP:0000655)4.69727849
18Cone-rod dystrophy (HP:0000548)4.59657415
19Retinitis pigmentosa (HP:0000510)4.54721951
20Macular degeneration (HP:0000608)4.48836319
21Choroideremia (HP:0001139)4.27116564
22Constricted visual fields (HP:0001133)4.12651724
23Posterior subcapsular cataract (HP:0007787)3.81518539
24Abnormality of the renal cortex (HP:0011035)3.54312407
25Absent speech (HP:0001344)3.32103536
26Gaze-evoked nystagmus (HP:0000640)3.27968084
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.18354873
28Renal cortical cysts (HP:0000803)3.14575180
29Abnormality of the renal medulla (HP:0100957)3.03561489
30Progressive visual loss (HP:0000529)2.80813953
31Gait imbalance (HP:0002141)2.80607380
32Congenital primary aphakia (HP:0007707)2.77507576
33Optic disc pallor (HP:0000543)2.73492075
34Retinal atrophy (HP:0001105)2.67851667
35Tubular atrophy (HP:0000092)2.66062626
36Congenital sensorineural hearing impairment (HP:0008527)2.63764692
37Fair hair (HP:0002286)2.55335373
38Hyperventilation (HP:0002883)2.51827926
39Nephrogenic diabetes insipidus (HP:0009806)2.47706563
40Wide nasal bridge (HP:0000431)2.42314712
41Protruding tongue (HP:0010808)2.42079665
42Medial flaring of the eyebrow (HP:0010747)2.40740431
43Subcapsular cataract (HP:0000523)2.38259816
44Hypothermia (HP:0002045)2.37210346
45Inability to walk (HP:0002540)2.35389627
46Neoplasm of the adrenal cortex (HP:0100641)2.34405916
47Progressive inability to walk (HP:0002505)2.32440797
48Stomach cancer (HP:0012126)2.29795847
49Type II lissencephaly (HP:0007260)2.18567666
50Tubulointerstitial nephritis (HP:0001970)2.17347315
51Poor coordination (HP:0002370)2.15992083
52Generalized hypopigmentation of hair (HP:0011358)2.15287611
53Absent/shortened dynein arms (HP:0200106)2.10686094
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.10686094
55Abnormality of the pons (HP:0007361)2.09700417
56Intestinal atresia (HP:0011100)2.09273030
57Postaxial foot polydactyly (HP:0001830)2.05562106
58Anencephaly (HP:0002323)2.05117223
59Supernumerary spleens (HP:0009799)2.04547697
60Methylmalonic acidemia (HP:0002912)2.04144734
61Volvulus (HP:0002580)2.04022536
62Congenital stationary night blindness (HP:0007642)16.2206815
63Bony spicule pigmentary retinopathy (HP:0007737)11.5846675
64Abnormal rod and cone electroretinograms (HP:0008323)10.1314021
65Increased CSF lactate (HP:0002490)1.99477661
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.98155961
67Stomatitis (HP:0010280)1.97848650
68Focal motor seizures (HP:0011153)1.97689509
69Hypoplasia of the pons (HP:0012110)1.97323126
70Progressive macrocephaly (HP:0004481)1.92100843
71Broad-based gait (HP:0002136)1.91595789
72Optic nerve hypoplasia (HP:0000609)1.91274687
73Abnormal ciliary motility (HP:0012262)1.90898765
74Vaginal atresia (HP:0000148)1.88173194
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.87820554
76Acute necrotizing encephalopathy (HP:0006965)1.87017866
77Progressive microcephaly (HP:0000253)1.84374633
78Colon cancer (HP:0003003)1.82001598
79Median cleft lip (HP:0000161)1.81621181
80Asplenia (HP:0001746)1.81484962
81Widely spaced teeth (HP:0000687)1.81412131
82Genital tract atresia (HP:0001827)1.80128819
83Abnormal respiratory motile cilium morphology (HP:0005938)1.79441675
84Abnormal respiratory epithelium morphology (HP:0012253)1.79441675
85Hypoplastic iliac wings (HP:0002866)1.78579471
86Epileptic encephalopathy (HP:0200134)1.76607622
87Hypoplastic pelvis (HP:0008839)1.74979838
88Abnormality of chromosome stability (HP:0003220)1.74275345
89Tubulointerstitial abnormality (HP:0001969)1.74186684
90Methylmalonic aciduria (HP:0012120)1.73742834
91Mitochondrial inheritance (HP:0001427)1.73731094
92Abnormal biliary tract physiology (HP:0012439)1.72425743
93Bile duct proliferation (HP:0001408)1.72425743
94Lissencephaly (HP:0001339)1.70856064
95Dysdiadochokinesis (HP:0002075)1.68682363
96Optic atrophy (HP:0000648)1.66581491
97True hermaphroditism (HP:0010459)1.65962997
98Severe Myopia (HP:0011003)1.64145559
99Febrile seizures (HP:0002373)1.59699701
100Hypoplasia of the fovea (HP:0007750)1.57947723
101Aplasia/Hypoplasia of the fovea (HP:0008060)1.57947723
102Aplasia/Hypoplasia of the lens (HP:0008063)1.56077751
103Abnormality of the fovea (HP:0000493)1.50662070
104Septo-optic dysplasia (HP:0100842)1.44055301
105Pancreatic fibrosis (HP:0100732)1.43490523
106Horizontal nystagmus (HP:0000666)1.43169999
107Astigmatism (HP:0000483)1.38839572
108Progressive cerebellar ataxia (HP:0002073)1.38610486
109Pancreatic cysts (HP:0001737)1.24773424
110Polar cataract (HP:0010696)1.23689914
111Left ventricular hypertrophy (HP:0001712)1.23357350
112Albinism (HP:0001022)1.21780277
113Cerebellar dysplasia (HP:0007033)1.21450352
114Interstitial pulmonary disease (HP:0006530)1.17022739
115Broad foot (HP:0001769)1.16085230
116Chorioretinal coloboma (HP:0000567)1.14937033
117Specific learning disability (HP:0001328)1.14831330
118Cystic liver disease (HP:0006706)1.14530407
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.14110957
120Aplasia/Hypoplasia of the macula (HP:0008059)1.11880028
121Genetic anticipation (HP:0003743)1.10623955
122Retinal detachment (HP:0000541)1.08615045
123Decreased testicular size (HP:0008734)1.06929971
124Truncal ataxia (HP:0002078)1.05758198
125Prolonged QT interval (HP:0001657)1.05689236
126Asthma (HP:0002099)1.03282241
127Aplasia/Hypoplasia affecting the retina (HP:0008061)1.01839902
128Molar tooth sign on MRI (HP:0002419)1.01159613
129Abnormality of midbrain morphology (HP:0002418)1.01159613
130Cholecystitis (HP:0001082)0.97725994
131Abnormal gallbladder physiology (HP:0012438)0.97725994
132Visual hallucinations (HP:0002367)0.96105772
133Partial agenesis of the corpus callosum (HP:0001338)0.93118449
134Sclerocornea (HP:0000647)0.88370465
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.87925284
136Abnormality of dental color (HP:0011073)0.86940286
137Chronic hepatic failure (HP:0100626)0.83915338
138Hypermetropia (HP:0000540)0.81625376
139Furrowed tongue (HP:0000221)0.80517106
140Heterotopia (HP:0002282)0.79096578
141Scanning speech (HP:0002168)0.79018849
142Postaxial hand polydactyly (HP:0001162)0.77724091
143Abnormal EKG (HP:0003115)0.77077698
144Dental crowding (HP:0000678)0.75883923
145Hypodontia (HP:0000668)0.75494258
146Recurrent sinusitis (HP:0011108)0.75350324
147Short foot (HP:0001773)0.75350312
148Dysmetric saccades (HP:0000641)0.71276626
149Syncope (HP:0001279)0.71180935
150Absence seizures (HP:0002121)0.70874468
151Nephronophthisis (HP:0000090)0.70455787
152Congenital hepatic fibrosis (HP:0002612)0.69801939
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)0.69581735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.08628397
2PBK8.65672625
3NUAK13.48920211
4PINK12.97827341
5WNK32.95392607
6MAP4K22.34335160
7ZAK2.33589674
8IRAK22.24807774
9BMPR1B2.01274835
10MAPK131.98843619
11TRIM281.95908516
12ADRBK21.89171077
13ACVR1B1.83821643
14NEK11.78300198
15CASK1.73562744
16PAK61.67053218
17TXK1.66191023
18INSRR1.62478555
19MST41.61348144
20TNIK1.58936283
21BRSK21.54829827
22WNK41.51373497
23TAOK31.48104600
24MAP3K41.47357600
25BCKDK1.46741815
26SIK21.45741103
27STK381.45357651
28EIF2AK31.41010685
29BRD41.40196276
30PHKG11.38980286
31PHKG21.38980286
32MUSK1.35027391
33CAMK1G1.33371966
34ADRBK11.31087715
35MKNK21.30512646
36DYRK1A1.29799474
37MAPK121.28591378
38MAPK71.28544727
39CAMK1D1.26069366
40CAMKK21.22765555
41OXSR11.22753928
42MARK11.22539468
43STK391.21488519
44VRK21.12500391
45PRKD31.09766440
46SGK2231.09708306
47SGK4941.09708306
48AKT31.07805549
49PLK41.03350172
50BCR1.02222204
51RPS6KA41.00989835
52CAMK2D0.99561388
53PRKCZ0.96691985
54PRPF4B0.95382703
55VRK10.94805129
56NEK60.94252290
57HIPK20.93477418
58MAP3K70.92757638
59CDK120.90330889
60PRKCE0.88742785
61CSNK1G20.87733736
62CSNK1D0.87191033
63TAOK20.86596831
64PRKAA10.86138558
65SGK20.85066203
66CSNK1G30.84753580
67CDK30.84122714
68MINK10.83089336
69FES0.80973426
70CCNB10.80482539
71CSNK1G10.80475579
72DAPK20.73477492
73NTRK30.72856204
74CSNK1A1L0.72642431
75MKNK10.72553768
76ICK0.72051136
77PRKCH0.70153368
78PTK2B0.68973788
79SGK30.68504950
80EPHA40.68355429
81TNK20.67822630
82PRKCB0.67625397
83EIF2AK10.66893541
84CAMKK10.65143658
85MAP3K120.64925581
86FGFR20.63963916
87RPS6KA30.62310158
88CAMK10.62182708
89PIK3CG0.61645028
90PNCK0.61386831
91DYRK20.61330344
92RIPK10.60958854
93ERBB20.60938946
94PRKACG0.60905588
95MAPKAPK50.60537451
96PRKAA20.60488089
97DAPK10.59563132
98WNK10.59419240
99FRK0.58732394
100CDK90.57579314
101PRKD20.57356299
102MAP3K100.56893758
103DYRK1B0.54317707
104MAPKAPK30.54234732
105WEE10.52933678
106PRKCI0.52687771
107PRKCQ0.51875681
108GSK3B0.51560915
109CDK50.51399937
110PLK10.50535213
111PRKCG0.49434410
112MAPK100.47327357
113PLK30.47245476
114NEK20.46670246
115PKN10.45444654
116TIE10.45082780
117CAMK2A0.44637827
118MARK30.43136455
119MAPK90.42973858
120GRK50.42837010
121MAPK140.42263531
122NME10.41977762
123STK30.41709201
124MAP2K70.40811932
125PRKDC0.40775454
126AKT20.40568970
127PRKACA0.39849430
128TTK0.39484977
129ATM0.39388701
130FLT30.38969782
131SGK10.38569008
132PRKCA0.38313382
133PDK20.38253778
134CAMK40.38218374
135TEC0.37985508
136LATS10.37147789
137EIF2AK20.36075272
138FER0.35960986
139ATR0.35181284
140PAK30.34838478
141ERBB30.34549817
142SRPK10.34284213
143TYK20.34236711
144CDK150.34010761
145MAP3K130.33991277
146CDK10.33055853
147CDK140.32033280
148PLK20.31666338
149CDK180.31212364
150STK38L0.30461596
151MAP3K90.30452590
152SIK10.29122365
153YES10.29105546
154PRKACB0.28773480
155MAPK80.28724048
156CDC42BPA0.28225789
157CDK11A0.27964165
158PRKG10.27853623
159CHEK20.27713444

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.30401211
2Protein export_Homo sapiens_hsa030602.25883111
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18547473
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14339026
5Butanoate metabolism_Homo sapiens_hsa006502.12443174
6Basal transcription factors_Homo sapiens_hsa030222.11168059
7Phototransduction_Homo sapiens_hsa0474415.4402032
8Propanoate metabolism_Homo sapiens_hsa006401.95345544
9Fanconi anemia pathway_Homo sapiens_hsa034601.94806197
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93297822
11Non-homologous end-joining_Homo sapiens_hsa034501.87297688
12Regulation of autophagy_Homo sapiens_hsa041401.79739290
13Olfactory transduction_Homo sapiens_hsa047401.65935520
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64419692
15GABAergic synapse_Homo sapiens_hsa047271.63144753
16Ether lipid metabolism_Homo sapiens_hsa005651.62664549
17Selenocompound metabolism_Homo sapiens_hsa004501.60884092
18Proteasome_Homo sapiens_hsa030501.45677733
19RNA polymerase_Homo sapiens_hsa030201.41280031
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.39090102
21* Synaptic vesicle cycle_Homo sapiens_hsa047211.38656220
22Circadian rhythm_Homo sapiens_hsa047101.30657233
23Morphine addiction_Homo sapiens_hsa050321.24377642
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23639398
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.20003446
26Tryptophan metabolism_Homo sapiens_hsa003801.16620275
27Ovarian steroidogenesis_Homo sapiens_hsa049131.15964706
28Oxidative phosphorylation_Homo sapiens_hsa001901.12443568
29Circadian entrainment_Homo sapiens_hsa047131.08224169
30Nicotine addiction_Homo sapiens_hsa050331.04644356
31Cholinergic synapse_Homo sapiens_hsa047251.03631874
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97669469
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97277435
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95644496
35Rheumatoid arthritis_Homo sapiens_hsa053230.89152791
36Glutamatergic synapse_Homo sapiens_hsa047240.87709779
37Dopaminergic synapse_Homo sapiens_hsa047280.87503206
38Nucleotide excision repair_Homo sapiens_hsa034200.87115337
39Fructose and mannose metabolism_Homo sapiens_hsa000510.86506350
40Peroxisome_Homo sapiens_hsa041460.85972428
41Chemical carcinogenesis_Homo sapiens_hsa052040.84702900
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84437235
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83879449
44Serotonergic synapse_Homo sapiens_hsa047260.82448348
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82229374
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81437160
47Arachidonic acid metabolism_Homo sapiens_hsa005900.80543358
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80411431
49Steroid biosynthesis_Homo sapiens_hsa001000.77360984
50Retinol metabolism_Homo sapiens_hsa008300.75118295
51Insulin secretion_Homo sapiens_hsa049110.75036983
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72702334
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72475092
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72138913
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69878129
56beta-Alanine metabolism_Homo sapiens_hsa004100.69186433
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68598580
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68474119
59One carbon pool by folate_Homo sapiens_hsa006700.66705722
60Type I diabetes mellitus_Homo sapiens_hsa049400.66587890
61ABC transporters_Homo sapiens_hsa020100.64188343
62Sphingolipid metabolism_Homo sapiens_hsa006000.64174049
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63948713
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61842914
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61824601
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61373026
67Metabolic pathways_Homo sapiens_hsa011000.61355191
68Hedgehog signaling pathway_Homo sapiens_hsa043400.59522047
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59267182
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59062184
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58633488
72Oxytocin signaling pathway_Homo sapiens_hsa049210.57871765
73Fatty acid degradation_Homo sapiens_hsa000710.57549361
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.57473177
75Fat digestion and absorption_Homo sapiens_hsa049750.56675519
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56327050
77Primary immunodeficiency_Homo sapiens_hsa053400.55805708
78Parkinsons disease_Homo sapiens_hsa050120.55402884
79Cardiac muscle contraction_Homo sapiens_hsa042600.55369887
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55363723
81Huntingtons disease_Homo sapiens_hsa050160.54310016
82Renin secretion_Homo sapiens_hsa049240.53360253
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51840562
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.50534069
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50451244
86Mismatch repair_Homo sapiens_hsa034300.50254240
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50243432
88Dilated cardiomyopathy_Homo sapiens_hsa054140.49947100
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49899453
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49415737
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.49274063
92Biosynthesis of amino acids_Homo sapiens_hsa012300.49189969
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49161986
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47684994
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47050004
96Caffeine metabolism_Homo sapiens_hsa002320.46997628
97Base excision repair_Homo sapiens_hsa034100.46776207
98Salivary secretion_Homo sapiens_hsa049700.46532958
99Allograft rejection_Homo sapiens_hsa053300.46494287
100Galactose metabolism_Homo sapiens_hsa000520.46416117
101RNA transport_Homo sapiens_hsa030130.45214633
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.43779122
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42860459
104Purine metabolism_Homo sapiens_hsa002300.42831099
105Fatty acid metabolism_Homo sapiens_hsa012120.42240541
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42092510
107Oocyte meiosis_Homo sapiens_hsa041140.40474736
108cAMP signaling pathway_Homo sapiens_hsa040240.38340097
109Dorso-ventral axis formation_Homo sapiens_hsa043200.36885303
110Mineral absorption_Homo sapiens_hsa049780.35243228
111Glycerolipid metabolism_Homo sapiens_hsa005610.34545225
112Inositol phosphate metabolism_Homo sapiens_hsa005620.33013421
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32459143
114Pentose phosphate pathway_Homo sapiens_hsa000300.31370127
115Calcium signaling pathway_Homo sapiens_hsa040200.30156965
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.29262450
117Arginine biosynthesis_Homo sapiens_hsa002200.28705115
118Type II diabetes mellitus_Homo sapiens_hsa049300.27443529
119mTOR signaling pathway_Homo sapiens_hsa041500.26890844
120Alcoholism_Homo sapiens_hsa050340.24980268
121HIF-1 signaling pathway_Homo sapiens_hsa040660.24777137
122Glucagon signaling pathway_Homo sapiens_hsa049220.24650329
123Fatty acid elongation_Homo sapiens_hsa000620.23451901
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21592421
125Cocaine addiction_Homo sapiens_hsa050300.21510757
126Gastric acid secretion_Homo sapiens_hsa049710.21103604
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.20505703
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20112113
129AMPK signaling pathway_Homo sapiens_hsa041520.19556389
130Collecting duct acid secretion_Homo sapiens_hsa049660.18904723
131Nitrogen metabolism_Homo sapiens_hsa009100.18227872
132Lysine degradation_Homo sapiens_hsa003100.17956143
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16915952
134Carbon metabolism_Homo sapiens_hsa012000.15927799
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15794243
136Bile secretion_Homo sapiens_hsa049760.14626703
137Chemokine signaling pathway_Homo sapiens_hsa040620.14492682
138Long-term potentiation_Homo sapiens_hsa047200.14023263
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.13940702
140Ras signaling pathway_Homo sapiens_hsa040140.13772933
141Amphetamine addiction_Homo sapiens_hsa050310.13481276
142Taste transduction_Homo sapiens_hsa047420.13330774
143Pancreatic secretion_Homo sapiens_hsa049720.12734531
144GnRH signaling pathway_Homo sapiens_hsa049120.11733420
145MAPK signaling pathway_Homo sapiens_hsa040100.11217407
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10494406
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10154159
148Linoleic acid metabolism_Homo sapiens_hsa005910.09075897
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.08690278
1502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08376217
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.06592671
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05802289
153RNA degradation_Homo sapiens_hsa030180.05585015
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05504069
155Gap junction_Homo sapiens_hsa045400.04863500
156Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.04813040
157Thyroid hormone synthesis_Homo sapiens_hsa049180.04370594
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03728213
159Maturity onset diabetes of the young_Homo sapiens_hsa049500.03075147
160Renal cell carcinoma_Homo sapiens_hsa052110.03065239
161Choline metabolism in cancer_Homo sapiens_hsa052310.03048915
162Endocytosis_Homo sapiens_hsa041440.02486293
163Pyruvate metabolism_Homo sapiens_hsa006200.02275493
164Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02191159
165Insulin resistance_Homo sapiens_hsa049310.02138712
166Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.01152476

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