CPLX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.36795410
2synaptic vesicle maturation (GO:0016188)6.23032205
3locomotory exploration behavior (GO:0035641)6.18377108
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.06893471
5vocalization behavior (GO:0071625)5.81893152
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.78948144
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.42767031
8regulation of glutamate receptor signaling pathway (GO:1900449)5.18390596
9cerebellar granule cell differentiation (GO:0021707)5.12366070
10* synaptic vesicle exocytosis (GO:0016079)5.08291290
11glutamate secretion (GO:0014047)5.04697497
12regulation of synaptic vesicle exocytosis (GO:2000300)4.92573409
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.92115759
14L-amino acid import (GO:0043092)4.90847290
15regulation of neuronal synaptic plasticity (GO:0048168)4.88407536
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.88270305
17regulation of synapse structural plasticity (GO:0051823)4.76312712
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.75071447
19exploration behavior (GO:0035640)4.73220350
20protein localization to synapse (GO:0035418)4.72793832
21neuronal action potential propagation (GO:0019227)4.68015310
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.61141785
23neurotransmitter secretion (GO:0007269)4.57629995
24amino acid import (GO:0043090)4.48882921
25regulation of synaptic vesicle transport (GO:1902803)4.43950500
26dendritic spine morphogenesis (GO:0060997)4.41898015
27potassium ion homeostasis (GO:0055075)4.32716012
28synaptic transmission, glutamatergic (GO:0035249)4.26709376
29long-term memory (GO:0007616)4.22289972
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.20434737
31neurotransmitter-gated ion channel clustering (GO:0072578)4.16441962
32axon ensheathment in central nervous system (GO:0032291)4.16333990
33central nervous system myelination (GO:0022010)4.16333990
34potassium ion import (GO:0010107)4.15458876
35layer formation in cerebral cortex (GO:0021819)4.14999773
36positive regulation of membrane potential (GO:0045838)4.13959936
37neuron cell-cell adhesion (GO:0007158)4.12984615
38glutamate receptor signaling pathway (GO:0007215)4.12079703
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08443147
40regulation of synapse maturation (GO:0090128)4.07277886
41neuron-neuron synaptic transmission (GO:0007270)4.06573175
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.06047450
43postsynaptic membrane organization (GO:0001941)3.96950041
44negative regulation of dendrite morphogenesis (GO:0050774)3.94345590
45regulation of voltage-gated calcium channel activity (GO:1901385)3.90857398
46positive regulation of synapse maturation (GO:0090129)3.89792145
47gamma-aminobutyric acid transport (GO:0015812)3.89532142
48regulation of dendritic spine morphogenesis (GO:0061001)3.89128046
49cellular sodium ion homeostasis (GO:0006883)3.84129100
50regulation of postsynaptic membrane potential (GO:0060078)3.81863434
51* regulation of synaptic plasticity (GO:0048167)3.75193625
52cellular potassium ion homeostasis (GO:0030007)3.73870568
53neuromuscular process controlling balance (GO:0050885)3.73212046
54proline transport (GO:0015824)3.65170931
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.62512268
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.62290615
57activation of protein kinase A activity (GO:0034199)3.59866042
58transmission of nerve impulse (GO:0019226)3.58748005
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.55365006
60* neurotransmitter transport (GO:0006836)3.54273924
61prepulse inhibition (GO:0060134)3.53886855
62auditory behavior (GO:0031223)3.52558089
63long-term synaptic potentiation (GO:0060291)3.49921574
64sodium ion export (GO:0071436)3.48825555
65regulation of vesicle fusion (GO:0031338)3.47409905
66neurotransmitter uptake (GO:0001504)3.47407491
67positive regulation of neurotransmitter transport (GO:0051590)3.46693770
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.45775425
69regulation of neurotransmitter secretion (GO:0046928)3.44809237
70regulation of neurotransmitter levels (GO:0001505)3.43686377
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42957108
72positive regulation of neurotransmitter secretion (GO:0001956)3.42855518
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.41167687
74dendritic spine organization (GO:0097061)3.38364092
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37624714
76synaptic vesicle endocytosis (GO:0048488)3.32601733
77acidic amino acid transport (GO:0015800)3.32302935
78neuromuscular process controlling posture (GO:0050884)3.29131663
79cell differentiation in hindbrain (GO:0021533)3.27005101
80neuronal ion channel clustering (GO:0045161)3.26681466
81membrane depolarization (GO:0051899)3.26338239
82regulation of neurotransmitter transport (GO:0051588)3.25978888
83positive regulation of dendritic spine development (GO:0060999)3.25780813
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24843128
85response to auditory stimulus (GO:0010996)3.24797885
86glycine transport (GO:0015816)3.24500030
87neuron recognition (GO:0008038)3.23439029
88cerebellar Purkinje cell differentiation (GO:0021702)3.23412094
89positive regulation of dendritic spine morphogenesis (GO:0061003)3.22217293
90neuromuscular synaptic transmission (GO:0007274)3.22191437
91regulation of dendritic spine development (GO:0060998)3.20240326
92cerebellar Purkinje cell layer development (GO:0021680)3.17962431
93behavioral defense response (GO:0002209)3.17300865
94behavioral fear response (GO:0001662)3.17300865
95learning (GO:0007612)3.16439434
96chemosensory behavior (GO:0007635)3.15822442
97membrane hyperpolarization (GO:0060081)3.14664500
98membrane depolarization during action potential (GO:0086010)3.13284727
99detection of calcium ion (GO:0005513)3.13247102
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10917709
101regulation of ARF protein signal transduction (GO:0032012)3.10346925
102positive regulation of synaptic transmission (GO:0050806)3.09512077
103gamma-aminobutyric acid signaling pathway (GO:0007214)3.09362296
104cell communication by electrical coupling (GO:0010644)3.09227198
105signal release (GO:0023061)3.08883015
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07380875
107intraspecies interaction between organisms (GO:0051703)3.07166735
108social behavior (GO:0035176)3.07166735
109fear response (GO:0042596)3.06967268
110negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05622768
111neuromuscular process (GO:0050905)3.05001619
112cell communication involved in cardiac conduction (GO:0086065)3.04433990
113positive regulation of vesicle fusion (GO:0031340)3.03281472
114* regulation of synaptic transmission (GO:0050804)3.02985984
115behavioral response to cocaine (GO:0048148)3.02245994
116dendrite morphogenesis (GO:0048813)3.01809598
117positive regulation of dendrite development (GO:1900006)3.01110858
118mating behavior (GO:0007617)3.00738594
119dicarboxylic acid transport (GO:0006835)3.00157022
120synaptic transmission (GO:0007268)2.99209917
121vesicle transport along microtubule (GO:0047496)2.98729811
122* regulation of exocytosis (GO:0017157)2.98208061
123regulation of female receptivity (GO:0045924)2.98057342
124innervation (GO:0060384)2.97778797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52331612
2* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19068824
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16025975
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14884152
5GBX2_23144817_ChIP-Seq_PC3_Human3.09318861
6* RARB_27405468_Chip-Seq_BRAIN_Mouse3.03322850
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.88861207
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82471901
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82471901
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77854030
11DROSHA_22980978_ChIP-Seq_HELA_Human2.73745199
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66087239
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63954181
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63647789
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62389739
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54071529
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52925579
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.51167298
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.37549399
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35480899
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.34168875
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33994651
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33039663
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.25051718
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.20172000
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12714805
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04238822
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88632621
29AR_21572438_ChIP-Seq_LNCaP_Human1.76793109
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76748520
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.74168947
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59832131
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54106336
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54021750
35SMAD4_21799915_ChIP-Seq_A2780_Human1.53038907
36* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40774418
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39991023
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36800434
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.36617039
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35490981
41ZNF274_21170338_ChIP-Seq_K562_Hela1.29923026
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26838139
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26624950
44KDM2B_26808549_Chip-Seq_K562_Human1.26449492
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26213902
46TAF15_26573619_Chip-Seq_HEK293_Human1.25438596
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23669023
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23335505
49* AR_19668381_ChIP-Seq_PC3_Human1.22402476
50* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21474075
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19087395
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.18565052
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18542864
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18040999
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17195484
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.17163714
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.16714952
58LXR_22292898_ChIP-Seq_THP-1_Human1.15833171
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15262947
60P300_19829295_ChIP-Seq_ESCs_Human1.14945058
61* STAT3_23295773_ChIP-Seq_U87_Human1.14455045
62AR_25329375_ChIP-Seq_VCAP_Human1.13801991
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12429096
64* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11956930
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11671366
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10014041
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08970668
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05595412
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04858523
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.04054893
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03772041
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03661421
73* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03480866
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03456978
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02856528
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.02820718
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02780867
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01697342
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.01066762
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00871705
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00737235
82OCT4_19829295_ChIP-Seq_ESCs_Human1.00715144
83TCF4_23295773_ChIP-Seq_U87_Human1.00399238
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.98566986
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97877724
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96698248
87CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96332047
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96301177
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95929955
90SMC4_20622854_ChIP-Seq_HELA_Human0.95910511
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.95399291
92* DPY_21335234_ChIP-Seq_ESCs_Mouse0.95214920
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.95017495
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94380663
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92944626
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.92389046
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92190404
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.91191656
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91160945
100CTCF_27219007_Chip-Seq_Bcells_Human0.91084757
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89903366
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89626774
103AHR_22903824_ChIP-Seq_MCF-7_Human0.89020145
104RUNX2_22187159_ChIP-Seq_PCA_Human0.88787749
105* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88588212
106IGF1R_20145208_ChIP-Seq_DFB_Human0.88534430
107TET1_21490601_ChIP-Seq_MESCs_Mouse0.88463072
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88319518
109KLF4_19829295_ChIP-Seq_ESCs_Human0.87916040
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87570753
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86507455
112* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86418172
113* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86319483
114RNF2_27304074_Chip-Seq_NSC_Mouse0.86169760
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85896185
116TP53_16413492_ChIP-PET_HCT116_Human0.85803145
117* PRDM14_20953172_ChIP-Seq_ESCs_Human0.85110976
118RXR_22108803_ChIP-Seq_LS180_Human0.84237833
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84001421
120CREB1_26743006_Chip-Seq_LNCaP_Human0.82078408
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81930230
122MYC_19915707_ChIP-ChIP_AK7_Human0.80935399
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79928026
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.79652508
125* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78900939
126RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77896807
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77331601
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.74248390
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71077969
130P68_20966046_ChIP-Seq_HELA_Human0.70938247
131KDM2B_26808549_Chip-Seq_DND41_Human0.70837197
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70272411
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.69993610
134NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.67863004
135EGR1_19032775_ChIP-ChIP_M12_Human0.67471239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.16536235
2MP0002822_catalepsy4.45659573
3MP0003880_abnormal_central_pattern4.35655641
4* MP0003635_abnormal_synaptic_transmissio4.35007537
5MP0004270_analgesia3.79741609
6MP0009745_abnormal_behavioral_response3.61215196
7* MP0002063_abnormal_learning/memory/cond3.44451971
8MP0002064_seizures3.24608122
9MP0009046_muscle_twitch3.05548502
10* MP0002572_abnormal_emotion/affect_behav2.83467496
11MP0001968_abnormal_touch/_nociception2.69297287
12MP0002272_abnormal_nervous_system2.64715908
13MP0001486_abnormal_startle_reflex2.57135105
14MP0002734_abnormal_mechanical_nocicepti2.56198246
15MP0005423_abnormal_somatic_nervous2.49638208
16MP0001501_abnormal_sleep_pattern2.38667100
17MP0002909_abnormal_adrenal_gland2.20770295
18MP0009780_abnormal_chondrocyte_physiolo2.16642826
19MP0002735_abnormal_chemical_nociception2.08566504
20MP0008569_lethality_at_weaning2.07351473
21MP0002733_abnormal_thermal_nociception1.99649877
22MP0001970_abnormal_pain_threshold1.96117392
23MP0002736_abnormal_nociception_after1.94073705
24MP0002067_abnormal_sensory_capabilities1.83045654
25MP0004811_abnormal_neuron_physiology1.81623231
26* MP0001440_abnormal_grooming_behavior1.78092903
27MP0002557_abnormal_social/conspecific_i1.77500375
28MP0005386_behavior/neurological_phenoty1.74985518
29MP0004924_abnormal_behavior1.74985518
30MP0002184_abnormal_innervation1.71823251
31MP0005646_abnormal_pituitary_gland1.71793620
32MP0003329_amyloid_beta_deposits1.71607444
33MP0003123_paternal_imprinting1.71157794
34MP0003879_abnormal_hair_cell1.68181232
35MP0004858_abnormal_nervous_system1.66261999
36MP0000955_abnormal_spinal_cord1.51739802
37MP0000778_abnormal_nervous_system1.49897862
38MP0004885_abnormal_endolymph1.46786811
39MP0001984_abnormal_olfaction1.42236245
40* MP0002066_abnormal_motor_capabilities/c1.40331475
41MP0003633_abnormal_nervous_system1.39772387
42MP0002882_abnormal_neuron_morphology1.36477639
43MP0001529_abnormal_vocalization1.36256711
44MP0003787_abnormal_imprinting1.33736314
45MP0006276_abnormal_autonomic_nervous1.30259732
46MP0001905_abnormal_dopamine_level1.27144268
47MP0005645_abnormal_hypothalamus_physiol1.26738884
48MP0001502_abnormal_circadian_rhythm1.25307416
49MP0000013_abnormal_adipose_tissue1.23268809
50MP0010386_abnormal_urinary_bladder1.19122823
51MP0003283_abnormal_digestive_organ1.14937330
52MP0003631_nervous_system_phenotype1.14608602
53MP0001188_hyperpigmentation1.14190956
54MP0003075_altered_response_to1.10519407
55MP0008872_abnormal_physiological_respon1.08858732
56MP0002152_abnormal_brain_morphology1.06246663
57MP0004142_abnormal_muscle_tone1.04466240
58MP0004147_increased_porphyrin_level1.02843550
59MP0008874_decreased_physiological_sensi1.00735182
60MP0001348_abnormal_lacrimal_gland1.00453092
61MP0008961_abnormal_basal_metabolism1.00429530
62MP0002069_abnormal_eating/drinking_beha0.99702643
63MP0005535_abnormal_body_temperature0.95747557
64MP0001177_atelectasis0.94465863
65MP0003122_maternal_imprinting0.91786404
66MP0005409_darkened_coat_color0.90060454
67MP0004145_abnormal_muscle_electrophysio0.89785489
68MP0002229_neurodegeneration0.88826188
69MP0004085_abnormal_heartbeat0.88348518
70MP0002837_dystrophic_cardiac_calcinosis0.85482320
71MP0001346_abnormal_lacrimal_gland0.85460231
72MP0002638_abnormal_pupillary_reflex0.83725278
73MP0000569_abnormal_digit_pigmentation0.82762719
74MP0005394_taste/olfaction_phenotype0.81421051
75MP0005499_abnormal_olfactory_system0.81421051
76MP0005551_abnormal_eye_electrophysiolog0.81222943
77MP0003632_abnormal_nervous_system0.78033230
78MP0000751_myopathy0.77438685
79MP0010234_abnormal_vibrissa_follicle0.77272342
80MP0004043_abnormal_pH_regulation0.74991726
81MP0005167_abnormal_blood-brain_barrier0.74533912
82MP0003634_abnormal_glial_cell0.74471006
83MP0002090_abnormal_vision0.74304905
84MP0003690_abnormal_glial_cell0.73783372
85MP0000631_abnormal_neuroendocrine_gland0.73377947
86MP0004742_abnormal_vestibular_system0.72331285
87MP0000604_amyloidosis0.70847330
88MP0008877_abnormal_DNA_methylation0.70799402
89MP0001986_abnormal_taste_sensitivity0.69576847
90MP0000920_abnormal_myelination0.68777233
91MP0001963_abnormal_hearing_physiology0.68501684
92MP0005623_abnormal_meninges_morphology0.68311050
93MP0001664_abnormal_digestion0.62102358
94MP0002752_abnormal_somatic_nervous0.62076614
95MP0004215_abnormal_myocardial_fiber0.61698054
96MP0004510_myositis0.61574787
97MP0003172_abnormal_lysosome_physiology0.61098603
98MP0003121_genomic_imprinting0.59090346
99MP0004484_altered_response_of0.56970918
100MP0005187_abnormal_penis_morphology0.56752295
101MP0004130_abnormal_muscle_cell0.56607806
102MP0000579_abnormal_nail_morphology0.56471881
103MP0003137_abnormal_impulse_conducting0.56350843
104MP0001485_abnormal_pinna_reflex0.56246679
105MP0002234_abnormal_pharynx_morphology0.55377417
106MP0010768_mortality/aging0.53863698
107MP0002082_postnatal_lethality0.52948215
108MP0001943_abnormal_respiration0.50938532
109MP0010769_abnormal_survival0.50803936
110MP0003956_abnormal_body_size0.50306578
111MP0002876_abnormal_thyroid_physiology0.47875225
112MP0010770_preweaning_lethality0.47601626
113MP0003861_abnormal_nervous_system0.46680097
114MP0000639_abnormal_adrenal_gland0.46626295
115MP0001765_abnormal_ion_homeostasis0.44226420
116MP0005166_decreased_susceptibility_to0.43868633
117MP0001731_abnormal_postnatal_growth0.43318183
118MP0001299_abnormal_eye_distance/0.43084403

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.11452668
2Myokymia (HP:0002411)7.90873349
3Focal seizures (HP:0007359)5.96670927
4Visual hallucinations (HP:0002367)5.82093078
5Epileptic encephalopathy (HP:0200134)4.56337606
6Action tremor (HP:0002345)4.53576064
7Atonic seizures (HP:0010819)4.38870944
8Progressive cerebellar ataxia (HP:0002073)4.38275227
9Febrile seizures (HP:0002373)4.30435280
10Absence seizures (HP:0002121)4.05783238
11Generalized tonic-clonic seizures (HP:0002069)3.86315660
12Dialeptic seizures (HP:0011146)3.77744881
13Tetraplegia (HP:0002445)3.71985264
14Poor eye contact (HP:0000817)3.64666075
15Cerebral hypomyelination (HP:0006808)3.63145470
16Depression (HP:0000716)3.59475973
17Gaze-evoked nystagmus (HP:0000640)3.58807279
18Broad-based gait (HP:0002136)3.54001658
19Papilledema (HP:0001085)3.53554748
20Ankle clonus (HP:0011448)3.46152917
21Anxiety (HP:0000739)3.44170386
22Impaired vibration sensation in the lower limbs (HP:0002166)3.43403403
23Supranuclear gaze palsy (HP:0000605)3.40797048
24Dysdiadochokinesis (HP:0002075)3.31512778
25Impaired social interactions (HP:0000735)3.31011283
26Abnormal social behavior (HP:0012433)3.31011283
27Dysmetria (HP:0001310)3.14270138
28Truncal ataxia (HP:0002078)3.12940943
29Amblyopia (HP:0000646)3.11684446
30Urinary bladder sphincter dysfunction (HP:0002839)3.05550783
31Akinesia (HP:0002304)3.01516895
32Postural instability (HP:0002172)3.00236489
33Impaired smooth pursuit (HP:0007772)3.00099471
34Hyperventilation (HP:0002883)2.96136337
35Torticollis (HP:0000473)2.95153982
36Abnormality of the lower motor neuron (HP:0002366)2.88467341
37Annular pancreas (HP:0001734)2.88435862
38Focal dystonia (HP:0004373)2.81622611
39Abnormal eating behavior (HP:0100738)2.75149330
40Genetic anticipation (HP:0003743)2.73991517
41Stereotypic behavior (HP:0000733)2.72635733
42Mutism (HP:0002300)2.69192607
43Intention tremor (HP:0002080)2.68625138
44Hemiparesis (HP:0001269)2.64382610
45Scanning speech (HP:0002168)2.62512303
46Ventricular fibrillation (HP:0001663)2.61037018
47Hemiplegia (HP:0002301)2.60856132
48Abnormality of ocular smooth pursuit (HP:0000617)2.58602453
49Urinary urgency (HP:0000012)2.56132753
50Bradykinesia (HP:0002067)2.55658849
51Spastic gait (HP:0002064)2.53327482
52Dysmetric saccades (HP:0000641)2.52148645
53Megalencephaly (HP:0001355)2.52100300
54Sleep apnea (HP:0010535)2.51581687
55Epileptiform EEG discharges (HP:0011182)2.47847927
56Craniofacial dystonia (HP:0012179)2.47234086
57Spastic tetraparesis (HP:0001285)2.47090390
58Cerebral inclusion bodies (HP:0100314)2.45873252
59Diplopia (HP:0000651)2.42379005
60Abnormality of binocular vision (HP:0011514)2.42379005
61Progressive inability to walk (HP:0002505)2.42346002
62EEG with generalized epileptiform discharges (HP:0011198)2.42127480
63Excessive salivation (HP:0003781)2.41868814
64Drooling (HP:0002307)2.41868814
65Peripheral hypomyelination (HP:0007182)2.40932346
66Pointed chin (HP:0000307)2.39065114
67Choreoathetosis (HP:0001266)2.38760940
68Resting tremor (HP:0002322)2.37718307
69Hypsarrhythmia (HP:0002521)2.34582569
70Impaired vibratory sensation (HP:0002495)2.33466953
71Limb dystonia (HP:0002451)2.33201248
72Neurofibrillary tangles (HP:0002185)2.32326688
73Diminished motivation (HP:0000745)2.31923050
74CNS hypomyelination (HP:0003429)2.25049027
75Ankyloglossia (HP:0010296)2.24671193
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24022679
77Absent speech (HP:0001344)2.21533526
78Status epilepticus (HP:0002133)2.21186717
79Agitation (HP:0000713)2.20994769
80Obstructive sleep apnea (HP:0002870)2.15231830
81Bundle branch block (HP:0011710)2.15157031
82Morphological abnormality of the pyramidal tract (HP:0002062)2.07057197
83Gait ataxia (HP:0002066)2.05748743
84Lower limb asymmetry (HP:0100559)2.05706609
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04104099
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.04104099
87Generalized myoclonic seizures (HP:0002123)2.03061296
88Termporal pattern (HP:0011008)2.02480312
89Insidious onset (HP:0003587)2.02480312
90Fetal akinesia sequence (HP:0001989)2.00111446
91Increased circulating renin level (HP:0000848)1.99885978
92Insomnia (HP:0100785)1.99070695
93Incomplete penetrance (HP:0003829)1.98452300
94Lower limb muscle weakness (HP:0007340)1.97627693
95Abnormal EKG (HP:0003115)1.97449363
96Clonus (HP:0002169)1.92016184
97Pheochromocytoma (HP:0002666)1.91002975
98Polyphagia (HP:0002591)1.87240975
99Delusions (HP:0000746)1.86240077
100Rigidity (HP:0002063)1.84740093
101Inability to walk (HP:0002540)1.84088475
102Psychosis (HP:0000709)1.82276794
103Neuronal loss in central nervous system (HP:0002529)1.81698258
104Bronchomalacia (HP:0002780)1.81181240
105Memory impairment (HP:0002354)1.80872485
106Rapidly progressive (HP:0003678)1.80637014
107Abnormality of saccadic eye movements (HP:0000570)1.80170611
108Spinal canal stenosis (HP:0003416)1.79997068
109Amyotrophic lateral sclerosis (HP:0007354)1.79203940
110Lower limb amyotrophy (HP:0007210)1.78593963
111Prolonged QT interval (HP:0001657)1.77396050
112Aplasia involving bones of the upper limbs (HP:0009823)1.76847352
113Aplasia of the phalanges of the hand (HP:0009802)1.76847352
114Aplasia involving bones of the extremities (HP:0009825)1.76847352
115Abnormality of the corticospinal tract (HP:0002492)1.76759702
116Postural tremor (HP:0002174)1.76476205
117Hand muscle atrophy (HP:0009130)1.76434104
118Unsteady gait (HP:0002317)1.75289858
119Apathy (HP:0000741)1.73478461
120Blue irides (HP:0000635)1.73325680
121Abnormality of the periventricular white matter (HP:0002518)1.71464627
122Heart block (HP:0012722)1.70915295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.10256875
2NTRK34.77325780
3MAP3K93.83829159
4MAP3K42.75917914
5DAPK22.74302896
6PRKD32.65408865
7MINK12.63284594
8KSR22.48535214
9MARK12.33148487
10MAP2K72.25594066
11CAMKK12.22473008
12PAK62.20878902
13RIPK42.18572711
14NTRK12.13830348
15NTRK21.94484549
16MAP2K41.68839884
17KSR11.68566699
18DAPK11.65310956
19ARAF1.64196905
20CDK51.61530306
21FES1.56518548
22MAP3K21.51776129
23MAP3K131.49132612
24TNIK1.44761290
25MAP3K121.44664724
26GRK51.42898905
27SIK21.40792876
28CAMKK21.39398573
29STK381.38910754
30PRPF4B1.36821277
31PNCK1.32588559
32PRKCG1.19288570
33PLK21.17534439
34TYRO31.16896353
35UHMK11.16168321
36TAOK11.11716672
37CAMK11.08576256
38MAPK131.04520407
39CDK191.02475781
40PRKCH1.00720772
41RAF10.99055806
42CAMK2A0.92281100
43STK110.91256335
44SGK2230.89358288
45SGK4940.89358288
46PTK2B0.88266666
47BMPR20.87531037
48RET0.86703179
49CASK0.85792794
50CDK180.85756324
51CDK150.85394405
52MAP3K10.84595190
53CDK140.82452309
54PINK10.81404728
55ALK0.81183577
56CAMK2B0.79025656
57MAPK120.78618799
58SGK20.75243436
59CDK11A0.75015343
60PDK10.73415828
61MARK20.72445885
62LIMK10.71882356
63SGK10.71281797
64SGK30.70881762
65DYRK1A0.68260070
66PDPK10.67658850
67PKN10.67080364
68RIPK10.65483072
69PAK30.64068088
70MAP3K110.61685477
71PHKG10.60358201
72PHKG20.60358201
73BRAF0.59659086
74LMTK20.59648468
75FGFR20.58638193
76LATS20.57625511
77CSNK1G20.56894989
78BRSK10.54885616
79MAP2K10.53152370
80TNK20.52085978
81SCYL20.51750104
82RPS6KA30.51744108
83CAMK40.51476953
84TESK10.51247088
85CDC42BPA0.49632067
86FYN0.48060974
87WNK10.47450194
88ROCK20.47045454
89PRKCZ0.47000441
90NEK60.44734706
91CAMK2D0.44292706
92PRKCE0.44017408
93MAPK100.43889593
94MAP3K70.43665170
95CAMK1G0.43463147
96PRKD20.43361214
97DAPK30.40331436
98WNK30.39831720
99CAMK2G0.39130372
100FGR0.38849392
101OXSR10.37701574
102FER0.36714954
103PRKG20.36611233
104NEK10.36108220
105IRAK20.36103680
106NME10.33972579
107DMPK0.33192387
108PRKCB0.32334254
109PRKCA0.32224918
110ERBB20.31958046
111MUSK0.30164012
112HIPK20.30079518
113MAPKAPK50.29143646
114MAP2K60.27901075
115ROCK10.27667206
116MAPK80.27044099
117SRC0.25368831
118CCNB10.23977319
119CSNK1E0.23246106

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.33024561
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.03566827
3Olfactory transduction_Homo sapiens_hsa047402.99423708
4Long-term potentiation_Homo sapiens_hsa047202.81071926
5Circadian entrainment_Homo sapiens_hsa047132.75781176
6Amphetamine addiction_Homo sapiens_hsa050312.68583398
7GABAergic synapse_Homo sapiens_hsa047272.62219395
8Glutamatergic synapse_Homo sapiens_hsa047242.62205961
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58427851
10Morphine addiction_Homo sapiens_hsa050322.51248385
11Dopaminergic synapse_Homo sapiens_hsa047282.28573039
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24418426
13Insulin secretion_Homo sapiens_hsa049112.22287462
14Salivary secretion_Homo sapiens_hsa049702.18683420
15Cholinergic synapse_Homo sapiens_hsa047252.09963064
16Aldosterone synthesis and secretion_Homo sapiens_hsa049252.02584616
17Gastric acid secretion_Homo sapiens_hsa049711.96420653
18Cocaine addiction_Homo sapiens_hsa050301.89298979
19Vitamin B6 metabolism_Homo sapiens_hsa007501.85202474
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72183504
21Oxytocin signaling pathway_Homo sapiens_hsa049211.71613265
22Renin secretion_Homo sapiens_hsa049241.71060926
23Long-term depression_Homo sapiens_hsa047301.70560265
24Taste transduction_Homo sapiens_hsa047421.69308584
25Serotonergic synapse_Homo sapiens_hsa047261.65283192
26Calcium signaling pathway_Homo sapiens_hsa040201.63394819
27GnRH signaling pathway_Homo sapiens_hsa049121.53453204
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45028352
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38049311
30Type II diabetes mellitus_Homo sapiens_hsa049301.37529327
31Gap junction_Homo sapiens_hsa045401.36376674
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35552445
33cAMP signaling pathway_Homo sapiens_hsa040241.32085494
34Glioma_Homo sapiens_hsa052141.24103797
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22612102
36Estrogen signaling pathway_Homo sapiens_hsa049151.20646275
37Collecting duct acid secretion_Homo sapiens_hsa049661.19058382
38Nitrogen metabolism_Homo sapiens_hsa009101.16464393
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10569040
40Melanogenesis_Homo sapiens_hsa049161.06043626
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05470299
42Pancreatic secretion_Homo sapiens_hsa049720.99478794
43ErbB signaling pathway_Homo sapiens_hsa040120.99344408
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.98327840
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92721866
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92454113
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91646448
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.89739461
49Oocyte meiosis_Homo sapiens_hsa041140.89041706
50Axon guidance_Homo sapiens_hsa043600.89018152
51Thyroid hormone synthesis_Homo sapiens_hsa049180.88315709
52Dorso-ventral axis formation_Homo sapiens_hsa043200.86744573
53Cardiac muscle contraction_Homo sapiens_hsa042600.86136508
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84106394
55Vibrio cholerae infection_Homo sapiens_hsa051100.81497271
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77763929
57Phototransduction_Homo sapiens_hsa047440.76897379
58Type I diabetes mellitus_Homo sapiens_hsa049400.76477894
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76157188
60Choline metabolism in cancer_Homo sapiens_hsa052310.73786403
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.71496926
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71239916
63VEGF signaling pathway_Homo sapiens_hsa043700.70375097
64MAPK signaling pathway_Homo sapiens_hsa040100.67669745
65Dilated cardiomyopathy_Homo sapiens_hsa054140.67468206
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66259504
67Glucagon signaling pathway_Homo sapiens_hsa049220.65829544
68Alcoholism_Homo sapiens_hsa050340.63624437
69mTOR signaling pathway_Homo sapiens_hsa041500.58888298
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58454242
71Rap1 signaling pathway_Homo sapiens_hsa040150.58006889
72Non-small cell lung cancer_Homo sapiens_hsa052230.55630190
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54569237
74Ras signaling pathway_Homo sapiens_hsa040140.54308920
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.54086138
76Inositol phosphate metabolism_Homo sapiens_hsa005620.53991690
77Arginine biosynthesis_Homo sapiens_hsa002200.51528648
78Arginine and proline metabolism_Homo sapiens_hsa003300.50992282
79Endocytosis_Homo sapiens_hsa041440.49322813
80Bile secretion_Homo sapiens_hsa049760.49153486
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47574622
82Circadian rhythm_Homo sapiens_hsa047100.47363213
83Prion diseases_Homo sapiens_hsa050200.44042389
84Endometrial cancer_Homo sapiens_hsa052130.43246704
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42073653
86African trypanosomiasis_Homo sapiens_hsa051430.41650170
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41497306
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40493716
89Chemokine signaling pathway_Homo sapiens_hsa040620.40452828
90Wnt signaling pathway_Homo sapiens_hsa043100.39973757
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39899336
92Insulin signaling pathway_Homo sapiens_hsa049100.38278452
93Fatty acid biosynthesis_Homo sapiens_hsa000610.37972566
94Mineral absorption_Homo sapiens_hsa049780.36866643
95Histidine metabolism_Homo sapiens_hsa003400.36724405
96Renal cell carcinoma_Homo sapiens_hsa052110.34730353
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34380611
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33786962
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32030436
100Ovarian steroidogenesis_Homo sapiens_hsa049130.31692850
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29504422
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27088204
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26743808
104Prolactin signaling pathway_Homo sapiens_hsa049170.26690256
105Platelet activation_Homo sapiens_hsa046110.26651566
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26629905
107AMPK signaling pathway_Homo sapiens_hsa041520.25932762
108beta-Alanine metabolism_Homo sapiens_hsa004100.25909959
109HIF-1 signaling pathway_Homo sapiens_hsa040660.25030973
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24765140
111Alzheimers disease_Homo sapiens_hsa050100.21117968
112Tight junction_Homo sapiens_hsa045300.20711895
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20371945
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17245793
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15330437

Most similar genes based on co-expression Upload to Enrichr

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