CPHL1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)8.78057595
2regulation of lipoprotein metabolic process (GO:0050746)8.73244117
3purine nucleotide transport (GO:0015865)8.72102327
4regulation of cytokine production involved in inflammatory response (GO:1900015)7.86616145
5regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)7.51968504
6short-chain fatty acid metabolic process (GO:0046459)7.51466737
7benzene-containing compound metabolic process (GO:0042537)7.44390668
8drinking behavior (GO:0042756)6.65623117
9negative regulation of adherens junction organization (GO:1903392)5.64344191
10negative regulation of focal adhesion assembly (GO:0051895)5.64344191
11negative regulation of cell junction assembly (GO:1901889)5.64344191
12negative regulation of chemokine production (GO:0032682)5.60652525
13positive regulation of chemokine secretion (GO:0090197)5.39440324
14nucleotide transport (GO:0006862)4.99747214
15primary alcohol catabolic process (GO:0034310)4.80383791
16regulation of chemokine secretion (GO:0090196)4.80124894
17positive regulation of glycolytic process (GO:0045821)4.64968039
18detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.56766110
19negative regulation of leukocyte migration (GO:0002686)4.54684857
20regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.35929428
21positive regulation of keratinocyte differentiation (GO:0045618)4.27208536
22axon regeneration (GO:0031103)4.09197580
23detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.96027490
24tryptophan catabolic process (GO:0006569)3.91930518
25indole-containing compound catabolic process (GO:0042436)3.91930518
26indolalkylamine catabolic process (GO:0046218)3.91930518
27positive regulation of action potential (GO:0045760)3.91269045
28piRNA metabolic process (GO:0034587)3.87409049
29tryptophan metabolic process (GO:0006568)3.84864087
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.80616083
31linoleic acid metabolic process (GO:0043651)3.76351951
32detection of light stimulus involved in visual perception (GO:0050908)3.74282405
33detection of light stimulus involved in sensory perception (GO:0050962)3.74282405
34retinal metabolic process (GO:0042574)3.72875710
35negative regulation of cell-matrix adhesion (GO:0001953)3.71716688
36kynurenine metabolic process (GO:0070189)3.67751458
37retina homeostasis (GO:0001895)3.63390589
38adhesion of symbiont to host cell (GO:0044650)3.56654150
39virion attachment to host cell (GO:0019062)3.56654150
40fucose catabolic process (GO:0019317)3.54945920
41L-fucose metabolic process (GO:0042354)3.54945920
42L-fucose catabolic process (GO:0042355)3.54945920
43regulation of phospholipid biosynthetic process (GO:0071071)3.48870859
44O-glycan processing (GO:0016266)3.46505896
45urinary tract smooth muscle contraction (GO:0014848)3.46130980
46ethanol metabolic process (GO:0006067)3.44246224
47regulation of keratinocyte differentiation (GO:0045616)3.37295253
48very-low-density lipoprotein particle assembly (GO:0034379)3.34798102
49tachykinin receptor signaling pathway (GO:0007217)3.32924175
50positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.31577239
51indolalkylamine metabolic process (GO:0006586)3.29379242
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26510382
53cellular ketone body metabolic process (GO:0046950)3.25871941
54tyrosine metabolic process (GO:0006570)3.25856641
55aggressive behavior (GO:0002118)3.20124734
56regulation of T cell migration (GO:2000404)3.18969433
57aromatic amino acid family catabolic process (GO:0009074)3.17567878
58negative regulation of smooth muscle cell proliferation (GO:0048662)3.15807657
59regulation of Golgi to plasma membrane protein transport (GO:0042996)3.14537982
60cellular biogenic amine catabolic process (GO:0042402)3.13752267
61amine catabolic process (GO:0009310)3.13752267
62positive regulation of cellular amine metabolic process (GO:0033240)3.10387823
63axon development (GO:0061564)3.08958506
64long-chain fatty acid biosynthetic process (GO:0042759)3.04310050
65DNA methylation involved in gamete generation (GO:0043046)3.02632322
66regulation of action potential (GO:0098900)3.00424158
67ketone body metabolic process (GO:1902224)2.98843722
68regulation of T cell mediated cytotoxicity (GO:0001914)2.97140323
69biotin metabolic process (GO:0006768)2.96064665
70regulation of memory T cell differentiation (GO:0043380)2.96028003
71sphingomyelin metabolic process (GO:0006684)2.91941148
72regulation of hydrogen peroxide metabolic process (GO:0010310)2.87153884
73positive regulation of uterine smooth muscle contraction (GO:0070474)2.86657157
74positive regulation of epidermal cell differentiation (GO:0045606)2.86265260
75adhesion of symbiont to host (GO:0044406)2.85070826
76white fat cell differentiation (GO:0050872)2.84499745
77negative regulation of JUN kinase activity (GO:0043508)2.82497651
78Golgi to endosome transport (GO:0006895)2.78047636
79regulation of protein polyubiquitination (GO:1902914)2.69900577
80valine metabolic process (GO:0006573)2.68057791
81protein import into peroxisome matrix (GO:0016558)2.64543614
82neuron projection regeneration (GO:0031102)2.60963305
83lactate metabolic process (GO:0006089)2.59561543
84intestinal epithelial cell development (GO:0060576)2.58420918
85negative regulation of complement activation (GO:0045916)2.56183181
86protein O-linked glycosylation (GO:0006493)2.56080213
87tissue regeneration (GO:0042246)2.53395143
88regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.53330813
89keratinocyte proliferation (GO:0043616)2.52866148
90positive regulation of vascular permeability (GO:0043117)2.52044789
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.51479186
92growth hormone receptor signaling pathway (GO:0060396)2.47765197
93aromatic amino acid family metabolic process (GO:0009072)2.45869349
94insulin-like growth factor receptor signaling pathway (GO:0048009)2.45713129
95primary alcohol metabolic process (GO:0034308)2.44890623
96negative regulation of reactive oxygen species metabolic process (GO:2000378)2.42953375
97lung secretory cell differentiation (GO:0061140)2.41691345
98positive regulation of cholesterol transport (GO:0032376)2.39836179
99positive regulation of sterol transport (GO:0032373)2.39836179
100fatty acid biosynthetic process (GO:0006633)2.36982693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human6.31711371
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.81944556
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.44162077
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.80112520
5ZNF217_24962896_ChIP-Seq_MCF-7_Human2.78036791
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.74328934
7ZNF274_21170338_ChIP-Seq_K562_Hela2.66269806
8PIAS1_25552417_ChIP-Seq_VCAP_Human2.54338020
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37087078
10VDR_22108803_ChIP-Seq_LS180_Human2.35504999
11FOXM1_26456572_ChIP-Seq_MCF-7_Human2.30148006
12GBX2_23144817_ChIP-Seq_PC3_Human2.29346281
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.08910404
14AHR_22903824_ChIP-Seq_MCF-7_Human2.07056509
15FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.95382582
16AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.93259033
17ER_23166858_ChIP-Seq_MCF-7_Human1.91854641
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89594790
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87237537
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.86061625
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85475277
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84293918
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.73723220
24GATA3_24758297_ChIP-Seq_MCF-7_Human1.72402302
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65721056
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62096627
27GATA4_25053715_ChIP-Seq_YYC3_Human1.54853208
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.54545605
29BCAT_22108803_ChIP-Seq_LS180_Human1.52987777
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52906381
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50235957
32CJUN_26792858_Chip-Seq_BT549_Human1.49869757
33RXR_22108803_ChIP-Seq_LS180_Human1.49175087
34ELF5_23300383_ChIP-Seq_T47D_Human1.48483884
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45424990
36IRF1_19129219_ChIP-ChIP_H3396_Human1.45080813
37CDX2_22108803_ChIP-Seq_LS180_Human1.42959811
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.42924740
39FOXA1_25552417_ChIP-Seq_VCAP_Human1.42538539
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42334839
41TCF4_22108803_ChIP-Seq_LS180_Human1.42172977
42AR_21909140_ChIP-Seq_LNCAP_Human1.40865439
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37049367
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36929069
45HOXB7_26014856_ChIP-Seq_BT474_Human1.35999378
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35030709
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.30011896
48AR_25329375_ChIP-Seq_VCAP_Human1.28100561
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.26012174
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.25956206
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25750822
52FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.24248887
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23996224
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23614879
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20459556
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20264487
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.19186084
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17822744
59CBP_20019798_ChIP-Seq_JUKART_Human1.17677048
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17677048
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16883536
62RUNX2_22187159_ChIP-Seq_PCA_Human1.16545383
63P300_19829295_ChIP-Seq_ESCs_Human1.14089431
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13963826
65GATA3_26560356_Chip-Seq_TH2_Human1.13530830
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13473003
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13244902
68STAT3_23295773_ChIP-Seq_U87_Human1.12921230
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12038003
70NANOG_19829295_ChIP-Seq_ESCs_Human1.11251350
71SOX2_19829295_ChIP-Seq_ESCs_Human1.11251350
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09646922
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.09579135
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09256758
75P53_22387025_ChIP-Seq_ESCs_Mouse1.08707916
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.06424522
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03544213
78SMAD4_21799915_ChIP-Seq_A2780_Human1.03212629
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03159746
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03054533
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.02044977
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.01957663
83TCF4_23295773_ChIP-Seq_U87_Human1.01805296
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.01466014
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.00703905
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.00683930
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00277935
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99908321
89AR_20517297_ChIP-Seq_VCAP_Human0.99691053
90RBPJ_21746931_ChIP-Seq_IB4_Human0.99638489
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.99062028
92ETV1_20927104_ChIP-Seq_GIST48_Human0.98983338
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98818177
94SALL1_21062744_ChIP-ChIP_HESCs_Human0.98245489
95TBL1_22424771_ChIP-Seq_293T_Human0.98017726
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97994789
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97946936
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95528978
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95169758
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93731128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism6.98363777
2MP0002166_altered_tumor_susceptibility3.69504426
3MP0009780_abnormal_chondrocyte_physiolo3.52979662
4MP0002009_preneoplasia3.50972997
5MP0003191_abnormal_cellular_cholesterol3.22624288
6MP0003941_abnormal_skin_development3.09955982
7MP0005310_abnormal_salivary_gland2.93899598
8MP0003195_calcinosis2.82431407
9MP0002006_tumorigenesis2.52417443
10MP0008995_early_reproductive_senescence2.49146474
11MP0001501_abnormal_sleep_pattern2.35533330
12MP0003724_increased_susceptibility_to2.33228478
13MP0010386_abnormal_urinary_bladder2.27492387
14MP0002876_abnormal_thyroid_physiology2.18907855
15MP0004264_abnormal_extraembryonic_tissu2.16305316
16MP0000372_irregular_coat_pigmentation2.07424262
17MP0001502_abnormal_circadian_rhythm2.05698436
18MP0008872_abnormal_physiological_respon1.97298632
19MP0004782_abnormal_surfactant_physiolog1.95964736
20MP0002938_white_spotting1.84377147
21MP0005670_abnormal_white_adipose1.77112004
22MP0005647_abnormal_sex_gland1.75469467
23MP0008875_abnormal_xenobiotic_pharmacok1.74930618
24MP0002736_abnormal_nociception_after1.73518247
25MP0006276_abnormal_autonomic_nervous1.71703648
26MP0010329_abnormal_lipoprotein_level1.63865431
27MP0005085_abnormal_gallbladder_physiolo1.56825253
28MP0005551_abnormal_eye_electrophysiolog1.47832393
29MP0002909_abnormal_adrenal_gland1.44455154
30MP0003252_abnormal_bile_duct1.43679591
31MP0005365_abnormal_bile_salt1.41302764
32MP0002796_impaired_skin_barrier1.40256078
33MP0002277_abnormal_respiratory_mucosa1.39449599
34MP0001727_abnormal_embryo_implantation1.37881667
35MP0004043_abnormal_pH_regulation1.36033816
36MP0005646_abnormal_pituitary_gland1.34846328
37MP0001968_abnormal_touch/_nociception1.32642581
38MP0000627_abnormal_mammary_gland1.31301028
39MP0000537_abnormal_urethra_morphology1.29103144
40MP0008877_abnormal_DNA_methylation1.28243198
41MP0002282_abnormal_trachea_morphology1.25497996
42MP0005408_hypopigmentation1.23264933
43MP0001919_abnormal_reproductive_system1.22776580
44MP0001485_abnormal_pinna_reflex1.20928513
45MP0000613_abnormal_salivary_gland1.18798793
46MP0003868_abnormal_feces_composition1.18685176
47MP0005083_abnormal_biliary_tract1.17630079
48MP0001881_abnormal_mammary_gland1.15047478
49MP0008961_abnormal_basal_metabolism1.14678336
50MP0006138_congestive_heart_failure1.13507844
51MP0002735_abnormal_chemical_nociception1.12594859
52MP0005503_abnormal_tendon_morphology1.08324845
53MP0009697_abnormal_copulation1.06198328
54MP0001529_abnormal_vocalization1.05352151
55MP0000427_abnormal_hair_cycle1.05250237
56MP0000383_abnormal_hair_follicle1.03161556
57MP0001661_extended_life_span1.01839962
58MP0004036_abnormal_muscle_relaxation1.01503167
59MP0001756_abnormal_urination0.99856725
60MP0002653_abnormal_ependyma_morphology0.99775553
61MP0002160_abnormal_reproductive_system0.98425350
62MP0002102_abnormal_ear_morphology0.96842527
63MP0002098_abnormal_vibrissa_morphology0.96623730
64MP0003315_abnormal_perineum_morphology0.96618622
65MP0004085_abnormal_heartbeat0.95947850
66MP0004084_abnormal_cardiac_muscle0.91653635
67MP0001666_abnormal_nutrient_absorption0.89037924
68MP0001873_stomach_inflammation0.87402416
69MP0009643_abnormal_urine_homeostasis0.86344530
70MP0002254_reproductive_system_inflammat0.85016326
71MP0003950_abnormal_plasma_membrane0.84089582
72MP0000230_abnormal_systemic_arterial0.83461119
73MP0002751_abnormal_autonomic_nervous0.82930692
74MP0003936_abnormal_reproductive_system0.82322826
75MP0000538_abnormal_urinary_bladder0.80901332
76MP0004381_abnormal_hair_follicle0.80782156
77MP0004019_abnormal_vitamin_homeostasis0.80421175
78MP0006072_abnormal_retinal_apoptosis0.79996874
79MP0005389_reproductive_system_phenotype0.79806110
80MP0004885_abnormal_endolymph0.79101933
81MP0002118_abnormal_lipid_homeostasis0.77588402
82MP0002557_abnormal_social/conspecific_i0.76661538
83MP0005275_abnormal_skin_tensile0.75450606
84MP0003011_delayed_dark_adaptation0.73776917
85MP0002933_joint_inflammation0.72548634
86MP0003638_abnormal_response/metabolism_0.70718145
87MP0004742_abnormal_vestibular_system0.68935861
88MP0005410_abnormal_fertilization0.65216313
89MP0000163_abnormal_cartilage_morphology0.64512036
90MP0001765_abnormal_ion_homeostasis0.63659193
91MP0005535_abnormal_body_temperature0.63144555
92MP0002108_abnormal_muscle_morphology0.62966620
93MP0003938_abnormal_ear_development0.60803447
94MP0005636_abnormal_mineral_homeostasis0.60417007
95MP0002168_other_aberrant_phenotype0.59246062
96MP0005075_abnormal_melanosome_morpholog0.58920183
97MP0003787_abnormal_imprinting0.58544651
98MP0000026_abnormal_inner_ear0.58122592
99MP0003646_muscle_fatigue0.57395251
100MP0002115_abnormal_skeleton_extremities0.56933806

Predicted human phenotypes

RankGene SetZ-score
1Breast carcinoma (HP:0003002)6.06575622
2Abnormality of the renal cortex (HP:0011035)4.17247816
3Tubular atrophy (HP:0000092)3.85276525
4Gonadotropin excess (HP:0000837)3.54694205
5Pancreatic cysts (HP:0001737)3.47725393
6Concave nail (HP:0001598)3.45889708
7Spontaneous abortion (HP:0005268)3.45379292
8Progressive inability to walk (HP:0002505)3.37264309
9Tubulointerstitial nephritis (HP:0001970)3.26681388
10Azoospermia (HP:0000027)3.14099053
11Lip pit (HP:0100267)3.05602226
12Prostate neoplasm (HP:0100787)3.04315909
13Testicular atrophy (HP:0000029)3.01470688
14Hyperglycinuria (HP:0003108)3.00288019
15Pancreatic fibrosis (HP:0100732)3.00019843
16Renal cortical cysts (HP:0000803)2.97058200
17Abnormality of the renal medulla (HP:0100957)2.96499201
18Abnormality of the axillary hair (HP:0100134)2.96278685
19Abnormality of secondary sexual hair (HP:0009888)2.96278685
20Conjugated hyperbilirubinemia (HP:0002908)2.94804319
21Chronic sinusitis (HP:0011109)2.91231322
22Inability to walk (HP:0002540)2.90792021
23Widely patent fontanelles and sutures (HP:0004492)2.88489592
24Cystic liver disease (HP:0006706)2.84604738
25Congenital stationary night blindness (HP:0007642)2.82981794
26Pulmonary artery stenosis (HP:0004415)2.79630824
27Decreased circulating renin level (HP:0003351)2.73744132
28Hypothermia (HP:0002045)2.66105100
29Type II lissencephaly (HP:0007260)2.65388040
30Recurrent bronchitis (HP:0002837)2.64502058
31Increased corneal curvature (HP:0100692)2.60453092
32Keratoconus (HP:0000563)2.60453092
33Stomach cancer (HP:0012126)2.60443317
34Nephronophthisis (HP:0000090)2.58200164
35True hermaphroditism (HP:0010459)2.52108370
36Autoamputation (HP:0001218)2.50718439
37Abnormal spermatogenesis (HP:0008669)2.45090296
38Delayed CNS myelination (HP:0002188)2.42462837
39Molar tooth sign on MRI (HP:0002419)2.37468324
40Abnormality of midbrain morphology (HP:0002418)2.37468324
41Bile duct proliferation (HP:0001408)2.34357531
42Abnormal biliary tract physiology (HP:0012439)2.34357531
43Arthropathy (HP:0003040)2.32383881
44Gaze-evoked nystagmus (HP:0000640)2.27133072
45Right ventricular cardiomyopathy (HP:0011663)2.27115446
46Male pseudohermaphroditism (HP:0000037)2.26543911
47Glomerulonephritis (HP:0000099)2.23801679
48Posterior subcapsular cataract (HP:0007787)2.23775394
49Generalized hypopigmentation of hair (HP:0011358)2.23405610
50Bronchitis (HP:0012387)2.20912879
51Abnormality of nail color (HP:0100643)2.18275517
52Tubulointerstitial abnormality (HP:0001969)2.15358167
53Chronic hepatic failure (HP:0100626)2.15303858
54Tubulointerstitial fibrosis (HP:0005576)2.15230469
55Severe Myopia (HP:0011003)2.14192698
56Abnormality of serine family amino acid metabolism (HP:0010894)2.13527524
57Abnormality of glycine metabolism (HP:0010895)2.13527524
58Febrile seizures (HP:0002373)2.11790282
59Genetic anticipation (HP:0003743)2.07176049
60Abnormality of renal excretion (HP:0011036)2.07168517
61Attenuation of retinal blood vessels (HP:0007843)2.05008877
62Abnormality of the nasal septum (HP:0000419)2.04558438
633-Methylglutaconic aciduria (HP:0003535)2.02834752
64Vascular calcification (HP:0004934)2.02322302
65Medial flaring of the eyebrow (HP:0010747)2.01337312
66Abnormal cartilage morphology (HP:0002763)1.99729478
67Anhidrosis (HP:0000970)1.98133427
68Testicular neoplasm (HP:0010788)1.98050906
69Ectropion (HP:0000656)1.98044340
70Intrahepatic cholestasis (HP:0001406)1.96364523
71Amelogenesis imperfecta (HP:0000705)1.96331594
72Abnormal biliary tract morphology (HP:0012440)1.95511861
73Pendular nystagmus (HP:0012043)1.93698985
74Abnormality of the prostate (HP:0008775)1.92136166
75Cerebral palsy (HP:0100021)1.88954679
76Calf muscle hypertrophy (HP:0008981)1.88557046
77Aplasia cutis congenita (HP:0001057)1.88430810
78Arterial tortuosity (HP:0005116)1.88072336
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87813639
80Abolished electroretinogram (ERG) (HP:0000550)1.87569362
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.86961047
82Congenital hepatic fibrosis (HP:0002612)1.86118250
83Median cleft lip (HP:0000161)1.82457692
84Absent/shortened dynein arms (HP:0200106)1.80779355
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.80779355
86Reduced antithrombin III activity (HP:0001976)1.78878745
87Epiphyseal stippling (HP:0010655)1.78223847
88Abnormality of renin-angiotensin system (HP:0000847)1.77795158
89Ketoacidosis (HP:0001993)1.76597531
90Congenital, generalized hypertrichosis (HP:0004540)1.76207415
91Short hallux (HP:0010109)1.75090248
92Cone-rod dystrophy (HP:0000548)1.73371256
93Vascular tortuosity (HP:0004948)1.72684208
94Abnormal respiratory motile cilium morphology (HP:0005938)1.71008896
95Abnormal respiratory epithelium morphology (HP:0012253)1.71008896
96Congenital ichthyosiform erythroderma (HP:0007431)1.70954513
97Adrenal hypoplasia (HP:0000835)1.69746267
98Barrel-shaped chest (HP:0001552)1.67584191
99Enlarged epiphyses (HP:0010580)1.67297303
100Broad nasal tip (HP:0000455)1.66968505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK26.27619562
2MST44.37614385
3FRK3.21726011
4EPHA22.89892997
5TNK22.73488918
6MAPKAPK32.38620777
7TRIM282.35055899
8STK392.26548710
9MST1R2.17411019
10WEE12.14413145
11BRSK11.95917300
12FER1.95270288
13STK38L1.94111145
14SIK31.82049349
15CAMKK21.76111797
16TAOK31.73721256
17GRK11.67975474
18EIF2AK31.65948769
19OXSR11.65054906
20CASK1.56786378
21WNK31.56667455
22MAP4K21.56445829
23PIK3CA1.56191845
24TLK11.56080379
25MATK1.54507897
26MAP3K71.51680366
27ERBB31.47954909
28SIK11.37731148
29ERBB21.36844306
30ADRBK21.36233317
31EIF2AK11.34239863
32NUAK11.32836260
33MAPK131.30445462
34ZAK1.25033787
35MET1.11291967
36SIK21.06905776
37TRPM71.05022959
38LATS11.03713938
39PRKAA20.99541417
40WNK40.98456258
41PIK3CG0.98397552
42MAPK150.97281776
43PINK10.94950429
44PAK30.91377095
45BMPR20.91333915
46BMPR1B0.88526562
47PRKAA10.84535239
48YES10.83127073
49PRKCE0.82465765
50CHUK0.76631751
51NTRK10.75776096
52PRKCI0.75308905
53IKBKB0.72396750
54PDGFRB0.62352707
55PHKG20.59884294
56PHKG10.59884294
57TNIK0.56966761
58IGF1R0.56462949
59EIF2AK20.53924610
60BCR0.51228594
61DYRK30.50676867
62MAP3K120.48204991
63ADRBK10.45270341
64NEK90.42632635
65IKBKE0.42386550
66INSRR0.42142955
67MAP3K40.41760055
68ABL10.39972268
69CSNK1A10.39780321
70STK30.38515121
71MKNK20.38482331
72PNCK0.37612679
73TEC0.36934037
74MAP2K70.35842832
75TIE10.35787710
76PRKCQ0.35004151
77CAMK1D0.34836865
78CSNK1E0.34037807
79KIT0.32976784
80PRKCG0.32464741
81MAP3K140.32398661
82NEK20.31971805
83CAMK1G0.31796443
84CAMKK10.29698084
85MUSK0.29646124
86RPS6KB10.28962664
87PRKCA0.27764733
88PLK40.27352520
89CDK30.26360678
90MAPKAPK50.25976529
91CAMK2D0.24030832
92FLT30.23948082
93CSNK1D0.21891438
94PTK2B0.21476190
95MAP2K20.20987319
96DYRK1A0.20207079
97MAPK80.20144327
98PRKACA0.19488584
99MARK30.17444613
100CAMK10.16443547

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006504.94136103
2ABC transporters_Homo sapiens_hsa020103.71694536
3Fatty acid biosynthesis_Homo sapiens_hsa000613.10387569
4Phenylalanine metabolism_Homo sapiens_hsa003602.84015671
5Histidine metabolism_Homo sapiens_hsa003402.76710864
6Caffeine metabolism_Homo sapiens_hsa002322.69054636
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43202496
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40914464
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.36999712
10Circadian rhythm_Homo sapiens_hsa047102.26986816
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22177357
12Linoleic acid metabolism_Homo sapiens_hsa005912.11766442
13Chemical carcinogenesis_Homo sapiens_hsa052042.10390413
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99800270
15Tyrosine metabolism_Homo sapiens_hsa003501.98776691
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85812064
17beta-Alanine metabolism_Homo sapiens_hsa004101.82435644
18Retinol metabolism_Homo sapiens_hsa008301.81182475
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76916574
20Nitrogen metabolism_Homo sapiens_hsa009101.71707751
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.67704335
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66229148
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.63504775
24Peroxisome_Homo sapiens_hsa041461.57265558
25Arachidonic acid metabolism_Homo sapiens_hsa005901.48842584
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.41206661
27PPAR signaling pathway_Homo sapiens_hsa033201.38337592
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34623029
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33070180
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31069216
31Starch and sucrose metabolism_Homo sapiens_hsa005001.29790539
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29140234
33Renin secretion_Homo sapiens_hsa049241.27621167
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23871409
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18195039
36Phototransduction_Homo sapiens_hsa047441.17743671
37Propanoate metabolism_Homo sapiens_hsa006401.15579142
38Regulation of autophagy_Homo sapiens_hsa041401.13625732
39Ether lipid metabolism_Homo sapiens_hsa005651.10455621
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07986532
41Tryptophan metabolism_Homo sapiens_hsa003801.01793414
42Fatty acid metabolism_Homo sapiens_hsa012120.99769065
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98229916
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96329899
45Sphingolipid metabolism_Homo sapiens_hsa006000.96015051
46Pancreatic secretion_Homo sapiens_hsa049720.94529892
47Fatty acid degradation_Homo sapiens_hsa000710.90269229
48Complement and coagulation cascades_Homo sapiens_hsa046100.88898639
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85950515
50Salivary secretion_Homo sapiens_hsa049700.85946322
51Mineral absorption_Homo sapiens_hsa049780.84048153
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.81588249
53Renin-angiotensin system_Homo sapiens_hsa046140.80700159
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.78647805
55Glycerolipid metabolism_Homo sapiens_hsa005610.77921309
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.75501286
57Olfactory transduction_Homo sapiens_hsa047400.72323332
58Selenocompound metabolism_Homo sapiens_hsa004500.71555169
59Basal transcription factors_Homo sapiens_hsa030220.66235404
60Taste transduction_Homo sapiens_hsa047420.66092994
61Sulfur metabolism_Homo sapiens_hsa009200.65825482
62Serotonergic synapse_Homo sapiens_hsa047260.64913892
63Ovarian steroidogenesis_Homo sapiens_hsa049130.58088311
64Protein export_Homo sapiens_hsa030600.54767922
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48468871
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48006302
67Type I diabetes mellitus_Homo sapiens_hsa049400.47537250
68Insulin secretion_Homo sapiens_hsa049110.45860103
69RNA degradation_Homo sapiens_hsa030180.44401850
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.39236834
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39117852
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39006471
73Asthma_Homo sapiens_hsa053100.38621647
74Fat digestion and absorption_Homo sapiens_hsa049750.38057450
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34732176
76Metabolic pathways_Homo sapiens_hsa011000.34082454
77Graft-versus-host disease_Homo sapiens_hsa053320.32563163
78Glutathione metabolism_Homo sapiens_hsa004800.32232973
79Allograft rejection_Homo sapiens_hsa053300.31710218
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30184328
81Autoimmune thyroid disease_Homo sapiens_hsa053200.29943520
82Choline metabolism in cancer_Homo sapiens_hsa052310.29363612
83Staphylococcus aureus infection_Homo sapiens_hsa051500.29077518
84Homologous recombination_Homo sapiens_hsa034400.27703227
85Dorso-ventral axis formation_Homo sapiens_hsa043200.27306737
86AMPK signaling pathway_Homo sapiens_hsa041520.24862213
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.24741525
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23654821
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23209292
90Insulin resistance_Homo sapiens_hsa049310.22703916
91Non-homologous end-joining_Homo sapiens_hsa034500.20266388
92Type II diabetes mellitus_Homo sapiens_hsa049300.19138786
93Calcium signaling pathway_Homo sapiens_hsa040200.18056847
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17798492
95ECM-receptor interaction_Homo sapiens_hsa045120.17109617
96Amphetamine addiction_Homo sapiens_hsa050310.16157141
97Glucagon signaling pathway_Homo sapiens_hsa049220.16040195
98Circadian entrainment_Homo sapiens_hsa047130.15803568
99RNA polymerase_Homo sapiens_hsa030200.15290689
100Steroid biosynthesis_Homo sapiens_hsa001000.14710480

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