CPEB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.42305053
2synapsis (GO:0007129)5.20654162
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71481226
4neuronal action potential propagation (GO:0019227)4.58056818
5DNA methylation involved in gamete generation (GO:0043046)4.56333544
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.54506759
7synaptic vesicle exocytosis (GO:0016079)4.47118084
8male meiosis I (GO:0007141)4.43798143
9behavioral response to nicotine (GO:0035095)4.41424258
10neuron cell-cell adhesion (GO:0007158)4.27510004
11positive regulation of meiosis (GO:0045836)4.26750347
12regulation of synaptic vesicle exocytosis (GO:2000300)4.25930363
13glutamate secretion (GO:0014047)4.05504431
14synaptic vesicle maturation (GO:0016188)4.00651545
15positive regulation of meiotic cell cycle (GO:0051446)3.97172570
16positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.93217804
17regulation of synaptic vesicle transport (GO:1902803)3.89000163
18sulfation (GO:0051923)3.73112233
19detection of calcium ion (GO:0005513)3.60853272
20DNA deamination (GO:0045006)3.57472508
21protein localization to synapse (GO:0035418)3.57332234
22vocalization behavior (GO:0071625)3.56461746
23male meiosis (GO:0007140)3.53835491
24protein polyglutamylation (GO:0018095)3.53564590
25regulation of meiosis I (GO:0060631)3.53230795
26branching involved in labyrinthine layer morphogenesis (GO:0060670)3.51836436
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47301544
28positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.46227140
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.44779105
30* chromosome organization involved in meiosis (GO:0070192)3.43710431
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41376872
32regulation of cell proliferation involved in kidney development (GO:1901722)3.38476814
33neurotransmitter secretion (GO:0007269)3.36869979
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.36423904
35NADH dehydrogenase complex assembly (GO:0010257)3.36423904
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36423904
37serotonin metabolic process (GO:0042428)3.36330493
38proline transport (GO:0015824)3.36012184
39presynaptic membrane assembly (GO:0097105)3.35027489
40membrane depolarization during action potential (GO:0086010)3.34473171
41locomotory exploration behavior (GO:0035641)3.33068228
42regulation of DNA endoreduplication (GO:0032875)3.32126271
43cell proliferation in forebrain (GO:0021846)3.31686163
44water-soluble vitamin biosynthetic process (GO:0042364)3.29288836
45regulation of female receptivity (GO:0045924)3.27084328
46meiosis I (GO:0007127)3.26792058
47regulation of vesicle fusion (GO:0031338)3.23581127
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.22087190
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19930730
50cellular potassium ion homeostasis (GO:0030007)3.18621881
51presynaptic membrane organization (GO:0097090)3.16756797
52primary amino compound metabolic process (GO:1901160)3.16368674
53neuron recognition (GO:0008038)3.15621619
54regulation of glutamate receptor signaling pathway (GO:1900449)3.14929230
55transmission of nerve impulse (GO:0019226)3.13079599
56cerebellar Purkinje cell differentiation (GO:0021702)3.11927123
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.10403853
58synaptic transmission, glutamatergic (GO:0035249)3.09172519
59neurotransmitter transport (GO:0006836)3.05374413
60neuron-neuron synaptic transmission (GO:0007270)3.03518222
61calcium-mediated signaling using intracellular calcium source (GO:0035584)3.02753337
62neuromuscular process controlling posture (GO:0050884)3.00648275
63synaptic vesicle endocytosis (GO:0048488)3.00637429
64synaptic vesicle docking involved in exocytosis (GO:0016081)3.00516170
65glutamate receptor signaling pathway (GO:0007215)2.98635735
66* regulation of neuronal synaptic plasticity (GO:0048168)2.97481543
67protein complex biogenesis (GO:0070271)2.97440436
68parturition (GO:0007567)2.97236127
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96866241
70positive regulation of potassium ion transmembrane transport (GO:1901381)2.96669783
71negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96382500
72retinal cone cell development (GO:0046549)2.94019174
73prostate gland growth (GO:0060736)2.93349543
74phenol-containing compound catabolic process (GO:0019336)2.92795241
75regulation of calcium ion-dependent exocytosis (GO:0017158)2.91748670
76positive regulation of potassium ion transport (GO:0043268)2.91508419
77activation of protein kinase A activity (GO:0034199)2.90408881
78innervation (GO:0060384)2.88976871
79neuromuscular synaptic transmission (GO:0007274)2.87282108
80regulation of neurotransmitter secretion (GO:0046928)2.87204530
81axonal fasciculation (GO:0007413)2.87124282
82righting reflex (GO:0060013)2.85183865
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84145180
84gamma-aminobutyric acid transport (GO:0015812)2.82747848
85regulation of neurotransmitter uptake (GO:0051580)2.82173256
86exploration behavior (GO:0035640)2.81261221
87regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81246759
88membrane depolarization (GO:0051899)2.79606526
89regulation of neurotransmitter levels (GO:0001505)2.77695134
90neuronal action potential (GO:0019228)2.76932031
91neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.76923341
92regulation of acrosome reaction (GO:0060046)2.76564827
93organelle transport along microtubule (GO:0072384)2.76354844
94neurotransmitter catabolic process (GO:0042135)2.75535513
95negative regulation of neurotransmitter transport (GO:0051589)2.74966317
96establishment of mitochondrion localization (GO:0051654)2.74336600
97regulation of postsynaptic membrane potential (GO:0060078)2.73953742
98regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73748953
99cell migration in hindbrain (GO:0021535)2.72866841
100phosphorelay signal transduction system (GO:0000160)2.72866340
101otic vesicle formation (GO:0030916)2.72827600
102regulation of neurotransmitter transport (GO:0051588)2.72204763
103mitochondrial respiratory chain complex assembly (GO:0033108)2.71612980
104sarcoplasmic reticulum calcium ion transport (GO:0070296)2.70570973
105indole-containing compound metabolic process (GO:0042430)2.70294625
106regulation of glomerulus development (GO:0090192)2.69932744
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69567350
108regulation of respiratory system process (GO:0044065)2.69404486
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69279690
110postsynaptic membrane organization (GO:0001941)2.68663141
111vesicle transport along microtubule (GO:0047496)2.68398212
112calcium ion-dependent exocytosis (GO:0017156)2.67821332
113positive regulation of cardiac muscle cell differentiation (GO:2000727)2.67656802
114glycerophospholipid catabolic process (GO:0046475)2.67416411
115mating behavior (GO:0007617)2.66813364
116pharyngeal system development (GO:0060037)2.66272149
117ovulation cycle (GO:0042698)2.66113165
118neurotransmitter-gated ion channel clustering (GO:0072578)2.65614207
119multicellular organism reproduction (GO:0032504)2.64950275
120regulation of action potential (GO:0098900)2.64662805
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63901124
122positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63885840
123regulation of amyloid precursor protein catabolic process (GO:1902991)2.63872014
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63320697
125glycine transport (GO:0015816)2.62921170
126cellular response to ATP (GO:0071318)2.62849941
127synaptic vesicle transport (GO:0048489)2.61712052
128establishment of synaptic vesicle localization (GO:0097480)2.61712052
129positive regulation of exocytosis (GO:0045921)2.61122427
130indolalkylamine metabolic process (GO:0006586)2.60890702
131resolution of meiotic recombination intermediates (GO:0000712)2.60148045
132negative regulation of mast cell activation (GO:0033004)2.59825832
133synaptic transmission (GO:0007268)2.59737228
134long-term synaptic potentiation (GO:0060291)2.59514027
135regulation of synaptic transmission, glutamatergic (GO:0051966)2.59038422
136protein targeting to Golgi (GO:0000042)2.58543496
137negative regulation of dendrite morphogenesis (GO:0050774)2.58374680
138detection of temperature stimulus involved in sensory perception (GO:0050961)2.58324148
139detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.58324148
140adult walking behavior (GO:0007628)2.58105576
141female mating behavior (GO:0060180)2.57621498
142regulation of female gonad development (GO:2000194)2.56786476
143negative regulation of Rho protein signal transduction (GO:0035024)2.56778766
144neuronal ion channel clustering (GO:0045161)2.56685092
145* synaptonemal complex organization (GO:0070193)2.55580453
146dendritic spine morphogenesis (GO:0060997)2.54752391
147regulation of exocytosis (GO:0017157)2.54735208
1483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.54632593
149purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.54632593
150nerve growth factor signaling pathway (GO:0038180)2.54516358
151long-term memory (GO:0007616)2.53670695
152behavioral response to ethanol (GO:0048149)2.53574512
153positive regulation of mitochondrial fission (GO:0090141)2.53155880
154detection of light stimulus involved in visual perception (GO:0050908)2.50586297
155detection of light stimulus involved in sensory perception (GO:0050962)2.50586297
156negative regulation of response to food (GO:0032096)2.50008250
157negative regulation of appetite (GO:0032099)2.50008250
158anterograde axon cargo transport (GO:0008089)2.49828638
159negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48458649
160magnesium ion transport (GO:0015693)2.47189566
161photoreceptor cell development (GO:0042461)2.46736000
162interkinetic nuclear migration (GO:0022027)2.44698802
163positive regulation of cAMP-mediated signaling (GO:0043950)2.42656382
164startle response (GO:0001964)2.41640525
165meiotic cell cycle (GO:0051321)2.41514808
166reciprocal DNA recombination (GO:0035825)2.41302778
167reciprocal meiotic recombination (GO:0007131)2.41302778
168indole-containing compound catabolic process (GO:0042436)2.41283213
169indolalkylamine catabolic process (GO:0046218)2.41283213
170tryptophan catabolic process (GO:0006569)2.41283213
171spindle assembly involved in mitosis (GO:0090307)2.40577036
172mitochondrion morphogenesis (GO:0070584)2.40287423
173negative regulation of systemic arterial blood pressure (GO:0003085)2.40236955
174preassembly of GPI anchor in ER membrane (GO:0016254)2.38702311
175meiotic nuclear division (GO:0007126)2.38508617
176action potential (GO:0001508)2.38138977
177axoneme assembly (GO:0035082)2.37234968
178dentate gyrus development (GO:0021542)2.36787955
179regulation of collateral sprouting (GO:0048670)2.35921813
180* synaptonemal complex assembly (GO:0007130)2.35436361
181regulation of mesoderm development (GO:2000380)2.34981769
182centrosome duplication (GO:0051298)2.34691185
183epithelial cilium movement (GO:0003351)2.33938849
184positive regulation of synapse maturation (GO:0090129)2.33927785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.55450547
2GBX2_23144817_ChIP-Seq_PC3_Human3.80233641
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92276366
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80292275
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65065912
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58572287
7REST_21632747_ChIP-Seq_MESCs_Mouse2.36583191
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29710880
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29710880
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29342043
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27572180
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27282909
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26467707
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.22882308
15TAF15_26573619_Chip-Seq_HEK293_Human2.19063546
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18805621
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09406906
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08966715
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.04054954
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98702971
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.92200950
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90603245
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.88715294
24DROSHA_22980978_ChIP-Seq_HELA_Human1.87534204
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.86401842
26AR_21572438_ChIP-Seq_LNCaP_Human1.86189127
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.86178049
28SMAD4_21799915_ChIP-Seq_A2780_Human1.86150912
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85548043
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80050050
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.76650767
32EWS_26573619_Chip-Seq_HEK293_Human1.74610290
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73437485
34* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72315080
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66871824
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66383910
37VDR_22108803_ChIP-Seq_LS180_Human1.64414995
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59815788
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59153851
40P300_19829295_ChIP-Seq_ESCs_Human1.58502871
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58480602
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58425847
43IGF1R_20145208_ChIP-Seq_DFB_Human1.56593456
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56320806
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.55322698
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54527472
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53608998
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50553347
49* STAT3_23295773_ChIP-Seq_U87_Human1.49763879
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49492214
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48304711
52IRF1_19129219_ChIP-ChIP_H3396_Human1.47879535
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.44931246
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42740405
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42205376
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38641169
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38157125
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.38081186
59ZNF274_21170338_ChIP-Seq_K562_Hela1.38001600
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37419847
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37400612
62AR_25329375_ChIP-Seq_VCAP_Human1.36551829
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.34633205
64MYC_18940864_ChIP-ChIP_HL60_Human1.33165628
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30144848
66* TCF4_23295773_ChIP-Seq_U87_Human1.29514570
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.28861448
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.26447410
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25750573
70CBP_20019798_ChIP-Seq_JUKART_Human1.25750573
71* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24095302
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21302850
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17304752
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17005176
75RNF2_27304074_Chip-Seq_NSC_Mouse1.16122342
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15947543
77BCAT_22108803_ChIP-Seq_LS180_Human1.15841275
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15759578
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.15615625
80* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15480145
81TP53_22573176_ChIP-Seq_HFKS_Human1.12707163
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11877136
83AR_19668381_ChIP-Seq_PC3_Human1.11855732
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11147284
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10584531
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10088764
87JUN_21703547_ChIP-Seq_K562_Human1.09692333
88ER_23166858_ChIP-Seq_MCF-7_Human1.09530198
89RUNX2_22187159_ChIP-Seq_PCA_Human1.09528916
90* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09503953
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08654955
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07745043
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07482304
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.07416934
95FUS_26573619_Chip-Seq_HEK293_Human1.06850822
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06393574
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.06393574
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05939484
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05920005
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.05591669
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.05530369
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05494867
103* NCOR_22424771_ChIP-Seq_293T_Human1.05458306
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.05069814
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.04861294
106NANOG_19829295_ChIP-Seq_ESCs_Human1.04273230
107SOX2_19829295_ChIP-Seq_ESCs_Human1.04273230
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03646235
109TCF4_22108803_ChIP-Seq_LS180_Human1.03293101
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02640967
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02318571
112AHR_22903824_ChIP-Seq_MCF-7_Human1.01760709
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01707149
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.01678801
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01219211
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01009695
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.00805270
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00798338
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97839520
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97839520
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97719423
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.96462809
123KDM2B_26808549_Chip-Seq_REH_Human0.94919074
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.94049958
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93842997
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93822279
127TP53_18474530_ChIP-ChIP_U2OS_Human0.93803089
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91361360
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90309406
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.90237326
131TP53_16413492_ChIP-PET_HCT116_Human0.89512748
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89506121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.49278079
2MP0003880_abnormal_central_pattern4.23294717
3MP0004270_analgesia4.04093566
4MP0008877_abnormal_DNA_methylation3.95904429
5MP0006292_abnormal_olfactory_placode3.90020308
6MP0001968_abnormal_touch/_nociception3.19728590
7* MP0003635_abnormal_synaptic_transmissio3.18289305
8MP0002734_abnormal_mechanical_nocicepti2.83964890
9MP0002735_abnormal_chemical_nociception2.82634263
10MP0002736_abnormal_nociception_after2.76090310
11MP0006276_abnormal_autonomic_nervous2.75223072
12MP0009745_abnormal_behavioral_response2.69838846
13MP0002064_seizures2.60053989
14MP0002272_abnormal_nervous_system2.53680411
15MP0002733_abnormal_thermal_nociception2.46443068
16MP0002837_dystrophic_cardiac_calcinosis2.44228135
17MP0002063_abnormal_learning/memory/cond2.43360026
18MP0009046_muscle_twitch2.39504586
19MP0002822_catalepsy2.36972926
20MP0002572_abnormal_emotion/affect_behav2.32481711
21MP0001970_abnormal_pain_threshold2.26842084
22MP0010386_abnormal_urinary_bladder2.18627420
23MP0001501_abnormal_sleep_pattern2.10825687
24MP0001486_abnormal_startle_reflex2.09543478
25MP0001440_abnormal_grooming_behavior2.05292599
26MP0003329_amyloid_beta_deposits2.02617678
27MP0005423_abnormal_somatic_nervous1.96297864
28MP0002067_abnormal_sensory_capabilities1.95410539
29MP0004858_abnormal_nervous_system1.91440155
30MP0009780_abnormal_chondrocyte_physiolo1.87639498
31MP0002909_abnormal_adrenal_gland1.87276044
32MP0004145_abnormal_muscle_electrophysio1.84490497
33* MP0002160_abnormal_reproductive_system1.84315061
34MP0003718_maternal_effect1.74589502
35MP0000013_abnormal_adipose_tissue1.72873379
36MP0002102_abnormal_ear_morphology1.71421231
37MP0001905_abnormal_dopamine_level1.70266838
38MP0002653_abnormal_ependyma_morphology1.68864111
39MP0005646_abnormal_pituitary_gland1.67729835
40MP0002184_abnormal_innervation1.67102191
41MP0004043_abnormal_pH_regulation1.67006284
42MP0002138_abnormal_hepatobiliary_system1.65528774
43MP0000049_abnormal_middle_ear1.65033925
44MP0001529_abnormal_vocalization1.62444292
45MP0005386_behavior/neurological_phenoty1.52699364
46MP0004924_abnormal_behavior1.52699364
47* MP0005389_reproductive_system_phenotype1.50734846
48MP0000778_abnormal_nervous_system1.47322734
49MP0005645_abnormal_hypothalamus_physiol1.47244949
50MP0008569_lethality_at_weaning1.46253110
51MP0000955_abnormal_spinal_cord1.45487676
52MP0002557_abnormal_social/conspecific_i1.42396380
53MP0002638_abnormal_pupillary_reflex1.37346645
54MP0000678_abnormal_parathyroid_gland1.36479724
55MP0003119_abnormal_digestive_system1.35620845
56* MP0002210_abnormal_sex_determination1.35504652
57MP0005253_abnormal_eye_physiology1.34096109
58MP0004142_abnormal_muscle_tone1.29910493
59MP0004811_abnormal_neuron_physiology1.29251602
60MP0000751_myopathy1.28641109
61MP0005410_abnormal_fertilization1.26956909
62MP0002882_abnormal_neuron_morphology1.26929086
63MP0001986_abnormal_taste_sensitivity1.25828155
64* MP0001929_abnormal_gametogenesis1.25216949
65MP0002066_abnormal_motor_capabilities/c1.25145097
66MP0008995_early_reproductive_senescence1.23930234
67MP0001984_abnormal_olfaction1.23405137
68MP0005379_endocrine/exocrine_gland_phen1.23022714
69MP0003633_abnormal_nervous_system1.22285954
70MP0000569_abnormal_digit_pigmentation1.19554653
71MP0002229_neurodegeneration1.18084362
72MP0001502_abnormal_circadian_rhythm1.16087188
73MP0003195_calcinosis1.15845661
74* MP0003698_abnormal_male_reproductive1.13886201
75MP0008058_abnormal_DNA_repair1.13527623
76* MP0000653_abnormal_sex_gland1.13127110
77MP0003122_maternal_imprinting1.11618841
78MP0003283_abnormal_digestive_organ1.11607296
79MP0003879_abnormal_hair_cell1.10357251
80* MP0001145_abnormal_male_reproductive1.08797051
81MP0003631_nervous_system_phenotype1.08267226
82MP0000920_abnormal_myelination1.07840770
83MP0003634_abnormal_glial_cell1.06650729
84MP0005535_abnormal_body_temperature1.06619848
85MP0001299_abnormal_eye_distance/1.04074976
86MP0005670_abnormal_white_adipose1.03419268
87MP0003890_abnormal_embryonic-extraembry1.03343019
88MP0003183_abnormal_peptide_metabolism1.01183618
89MP0000747_muscle_weakness1.00788209
90MP0005174_abnormal_tail_pigmentation0.99855382
91MP0006072_abnormal_retinal_apoptosis0.98377656
92MP0004133_heterotaxia0.97632315
93MP0002876_abnormal_thyroid_physiology0.96685049
94MP0003693_abnormal_embryo_hatching0.96377840
95MP0003787_abnormal_imprinting0.96153815
96MP0001919_abnormal_reproductive_system0.96121171
97MP0004742_abnormal_vestibular_system0.94777627
98MP0000372_irregular_coat_pigmentation0.93947932
99MP0003937_abnormal_limbs/digits/tail_de0.92815859
100MP0008789_abnormal_olfactory_epithelium0.92577985
101MP0000516_abnormal_urinary_system0.92327806
102MP0005367_renal/urinary_system_phenotyp0.92327806
103MP0004885_abnormal_endolymph0.92292265
104MP0004215_abnormal_myocardial_fiber0.91445741
105MP0009384_cardiac_valve_regurgitation0.91434186
106MP0004036_abnormal_muscle_relaxation0.89181375
107MP0005195_abnormal_posterior_eye0.88714642
108MP0000427_abnormal_hair_cycle0.87966014
109MP0004085_abnormal_heartbeat0.87516972
110MP0009250_abnormal_appendicular_skeleto0.86406574
111MP0005171_absent_coat_pigmentation0.85868038
112MP0003632_abnormal_nervous_system0.85414049
113MP0000604_amyloidosis0.85132540
114MP0003567_abnormal_fetal_cardiomyocyte0.85031514
115MP0002163_abnormal_gland_morphology0.83678223
116MP0003011_delayed_dark_adaptation0.83336161
117MP0002152_abnormal_brain_morphology0.82082816
118MP0002693_abnormal_pancreas_physiology0.81897062
119MP0005551_abnormal_eye_electrophysiolog0.81660034
120MP0002069_abnormal_eating/drinking_beha0.81238131
121MP0003938_abnormal_ear_development0.81179132
122MP0000749_muscle_degeneration0.81162138
123MP0002752_abnormal_somatic_nervous0.78362045
124MP0001485_abnormal_pinna_reflex0.77988617
125MP0001963_abnormal_hearing_physiology0.77789296
126MP0003690_abnormal_glial_cell0.76844696
127MP0001188_hyperpigmentation0.72378581
128MP0000538_abnormal_urinary_bladder0.71979735
129MP0000631_abnormal_neuroendocrine_gland0.71672081
130MP0002751_abnormal_autonomic_nervous0.68749799
131MP0004484_altered_response_of0.68335878
132MP0008872_abnormal_physiological_respon0.68237335
133MP0000003_abnormal_adipose_tissue0.68043321
134MP0008874_decreased_physiological_sensi0.66480794
135MP0003646_muscle_fatigue0.63913421
136MP0001664_abnormal_digestion0.63195564
137MP0002078_abnormal_glucose_homeostasis0.63013024
138MP0001944_abnormal_pancreas_morphology0.61703325
139MP0003137_abnormal_impulse_conducting0.60187905
140MP0005620_abnormal_muscle_contractility0.59774467
141MP0001765_abnormal_ion_homeostasis0.58384836

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.99916946
2Myokymia (HP:0002411)5.49521899
3Focal seizures (HP:0007359)4.57873748
4Atonic seizures (HP:0010819)4.45254746
5Visual hallucinations (HP:0002367)4.28714034
6Hypothermia (HP:0002045)3.94185427
7Action tremor (HP:0002345)3.79908688
8Febrile seizures (HP:0002373)3.69598174
9Absence seizures (HP:0002121)3.64498788
10Supranuclear gaze palsy (HP:0000605)3.63102216
11Progressive cerebellar ataxia (HP:0002073)3.60616407
12Generalized tonic-clonic seizures (HP:0002069)3.49790567
13Epileptic encephalopathy (HP:0200134)3.49513726
14Dialeptic seizures (HP:0011146)3.42307809
15Insidious onset (HP:0003587)3.38603129
16Termporal pattern (HP:0011008)3.38603129
17Pendular nystagmus (HP:0012043)3.37092196
18Pheochromocytoma (HP:0002666)3.32784311
19True hermaphroditism (HP:0010459)3.30404414
20Stenosis of the external auditory canal (HP:0000402)3.27940660
21Ectopic kidney (HP:0000086)3.26782557
22Short 1st metacarpal (HP:0010034)3.26278174
23Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.26278174
24Pancreatic fibrosis (HP:0100732)3.21701941
25Pancreatic cysts (HP:0001737)3.08618668
26Abnormality of the renal collecting system (HP:0004742)3.01382411
27Neurofibrillary tangles (HP:0002185)3.00810805
28Ankle clonus (HP:0011448)2.98718792
29Amblyopia (HP:0000646)2.89924245
30Truncal ataxia (HP:0002078)2.89885284
31Neuroendocrine neoplasm (HP:0100634)2.87424442
32Dysmetria (HP:0001310)2.83611079
33Cerebral inclusion bodies (HP:0100314)2.82405834
34Abnormality of DNA repair (HP:0003254)2.82013556
35Congenital stationary night blindness (HP:0007642)2.81976882
36Abolished electroretinogram (ERG) (HP:0000550)2.81867907
37Abnormality of the 1st metacarpal (HP:0010009)2.81169250
38Abnormality of midbrain morphology (HP:0002418)2.79267920
39Molar tooth sign on MRI (HP:0002419)2.79267920
40Ulnar claw (HP:0001178)2.78087431
41Nephronophthisis (HP:0000090)2.75539737
42Absent thumb (HP:0009777)2.74178102
43Absent/shortened dynein arms (HP:0200106)2.69084201
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.69084201
45Abnormality of the corticospinal tract (HP:0002492)2.68711578
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.67385434
47Agitation (HP:0000713)2.64911220
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.63939563
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.63939563
50Gaze-evoked nystagmus (HP:0000640)2.59959882
51Osteomalacia (HP:0002749)2.57854808
52Scanning speech (HP:0002168)2.57701969
53Anxiety (HP:0000739)2.57557986
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.56369166
55Spastic gait (HP:0002064)2.55867534
56Impaired vibration sensation in the lower limbs (HP:0002166)2.55520184
57Retinal dysplasia (HP:0007973)2.53335376
58Epileptiform EEG discharges (HP:0011182)2.48670676
59Hemiparesis (HP:0001269)2.47616427
60EEG with generalized epileptiform discharges (HP:0011198)2.42389486
61Postural tremor (HP:0002174)2.42150059
62Urinary bladder sphincter dysfunction (HP:0002839)2.41285681
63Congenital sensorineural hearing impairment (HP:0008527)2.40533821
64Short hallux (HP:0010109)2.38852473
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38774460
66Carpal bone hypoplasia (HP:0001498)2.38598347
67Dysdiadochokinesis (HP:0002075)2.38591387
68Depression (HP:0000716)2.36876862
69Methylmalonic acidemia (HP:0002912)2.34763587
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.32315019
71Hammertoe (HP:0001765)2.29890529
72Hypsarrhythmia (HP:0002521)2.29362033
73Limb dystonia (HP:0002451)2.29267219
74Hypoplasia of the uterus (HP:0000013)2.27878335
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27792079
76Dysautonomia (HP:0002459)2.26868671
77Abnormal rod and cone electroretinograms (HP:0008323)2.26339090
78Lower limb muscle weakness (HP:0007340)2.25887925
79Abnormality of the renal medulla (HP:0100957)2.25084111
80Abnormality of calcium-phosphate metabolism (HP:0100530)2.24767702
81Keratoconus (HP:0000563)2.23842363
82Increased corneal curvature (HP:0100692)2.23842363
83Chromsome breakage (HP:0040012)2.23465966
84Short phalanx of the thumb (HP:0009660)2.22336475
85Bony spicule pigmentary retinopathy (HP:0007737)2.21314508
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21045311
87Urinary urgency (HP:0000012)2.20869864
88Peripheral hypomyelination (HP:0007182)2.19240714
89Failure to thrive in infancy (HP:0001531)2.18829979
90Myotonia (HP:0002486)2.18677690
91Abnormal autonomic nervous system physiology (HP:0012332)2.18367851
92Abnormal eating behavior (HP:0100738)2.17798513
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.16973109
94Bradycardia (HP:0001662)2.15994921
95Chorioretinal atrophy (HP:0000533)2.14932640
96Tachypnea (HP:0002789)2.14575341
97Hyperventilation (HP:0002883)2.13926544
98Broad-based gait (HP:0002136)2.13009766
99Duplicated collecting system (HP:0000081)2.12645654
100Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11538826
101Male pseudohermaphroditism (HP:0000037)2.11528159
102Abnormality of the nasal septum (HP:0000419)2.08651856
103Excessive salivation (HP:0003781)2.05953650
104Drooling (HP:0002307)2.05953650
105Abnormality of the proximal phalanges of the hand (HP:0009834)2.04903407
106Aplasia/Hypoplasia of the tibia (HP:0005772)2.04353294
107Abnormality of the renal cortex (HP:0011035)2.03209788
108Decreased circulating renin level (HP:0003351)2.02320878
109Abnormality of binocular vision (HP:0011514)2.02081915
110Diplopia (HP:0000651)2.02081915
111Aplasia/hypoplasia of the uterus (HP:0008684)2.01392761
112Decreased central vision (HP:0007663)2.00956251
113Abnormality of the middle phalanges of the toes (HP:0010183)2.00674439
114Attenuation of retinal blood vessels (HP:0007843)2.00179839
115Psychosis (HP:0000709)2.00038560
116Anomalous pulmonary venous return (HP:0010772)1.99974824
117Genital tract atresia (HP:0001827)1.98319545
118Impaired smooth pursuit (HP:0007772)1.96187638
119Genetic anticipation (HP:0003743)1.96067502
120Type II lissencephaly (HP:0007260)1.95796107
121Asplenia (HP:0001746)1.95334262
122Steppage gait (HP:0003376)1.94801931
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.93604166
124Gait imbalance (HP:0002141)1.92888546
125Short tibia (HP:0005736)1.91836957
126Status epilepticus (HP:0002133)1.91784556
127Abnormal ciliary motility (HP:0012262)1.90972716
128Abnormality of the phalanges of the 5th finger (HP:0004213)1.90303795
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.90244187
130Cystic liver disease (HP:0006706)1.89814492
131Impaired vibratory sensation (HP:0002495)1.88418280
132Meckel diverticulum (HP:0002245)1.88393115
133Clonus (HP:0002169)1.88227064
134Synostosis of carpal bones (HP:0005048)1.88071729
135Abnormal respiratory epithelium morphology (HP:0012253)1.87972663
136Abnormal respiratory motile cilium morphology (HP:0005938)1.87972663
137Anosmia (HP:0000458)1.87823335
138Gait ataxia (HP:0002066)1.87064743
139Papilledema (HP:0001085)1.86988243
140Delusions (HP:0000746)1.86814210
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86054531
142Abnormality of alanine metabolism (HP:0010916)1.86054531
143Hyperalaninemia (HP:0003348)1.86054531
144Abnormal drinking behavior (HP:0030082)1.85789454
145Polydipsia (HP:0001959)1.85789454
146Abnormality of the ileum (HP:0001549)1.85549417
147Vaginal atresia (HP:0000148)1.85539680
148Onion bulb formation (HP:0003383)1.85443032
149Progressive inability to walk (HP:0002505)1.84821442
150Chronic hepatic failure (HP:0100626)1.84603246
151Blue irides (HP:0000635)1.84444590
152Postural instability (HP:0002172)1.83066242
153Horseshoe kidney (HP:0000085)1.82226131
154Rapidly progressive (HP:0003678)1.80500210
155Bradykinesia (HP:0002067)1.80407953
156Neuronal loss in central nervous system (HP:0002529)1.80233976
157Oligomenorrhea (HP:0000876)1.78671656
158Abnormality of pain sensation (HP:0010832)1.78518853
159Impaired pain sensation (HP:0007328)1.78518853
160Congenital primary aphakia (HP:0007707)1.78483102
161Nuclear cataract (HP:0100018)1.78371078
162Acute necrotizing encephalopathy (HP:0006965)1.77422683
163Fetal akinesia sequence (HP:0001989)1.77348263
164Medial flaring of the eyebrow (HP:0010747)1.76599876
165Muscle hypertrophy of the lower extremities (HP:0008968)1.76250655
166Small hand (HP:0200055)1.76087168
167Increased circulating renin level (HP:0000848)1.76026196
168Intention tremor (HP:0002080)1.75936953
169Methylmalonic aciduria (HP:0012120)1.75747630
170Hypoventilation (HP:0002791)1.75624792
171Abnormality of chromosome stability (HP:0003220)1.75568711
172Sensory axonal neuropathy (HP:0003390)1.75447775
173Optic nerve hypoplasia (HP:0000609)1.75025463
174Progressive macrocephaly (HP:0004481)1.75011846
175Poor eye contact (HP:0000817)1.74179431
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.73821914
177Sclerocornea (HP:0000647)1.72737583
178Abnormality of the pulmonary veins (HP:0011718)1.72661697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.43539983
2MAP3K93.38539309
3MAP3K43.33380875
4GRK13.20190475
5TLK12.76259151
6NTRK12.73653116
7MAP2K72.57839841
8EPHA42.53754955
9ADRBK22.51775404
10ACVR1B2.33145229
11PNCK2.28173795
12KSR22.24369555
13MINK12.17913555
14MAP2K42.17045274
15ZAK2.15185441
16PRKD32.12655538
17GRK51.97956052
18CASK1.95962453
19MAP3K121.92627296
20ARAF1.85820119
21WNK31.74366882
22STK391.73429335
23NUAK11.72121355
24MAP3K21.71947853
25RIPK41.67698320
26PAK61.67206818
27MAP4K21.55120905
28TNIK1.54874888
29WNK41.48395316
30INSRR1.44318180
31PHKG21.35328134
32PHKG11.35328134
33MARK11.35255662
34STK161.34740985
35OXSR11.34664658
36BMPR21.34434046
37MAP3K131.34119912
38DAPK21.27531599
39CDK51.26291867
40PLK21.25380326
41MAPK131.24259535
42NTRK21.22798599
43MAPKAPK51.21604108
44UHMK11.21012788
45MAP3K11.17829087
46CAMK2A1.16518905
47WNK11.16399558
48STK381.15413748
49SGK2231.15012285
50SGK4941.15012285
51PLK41.13411156
52CDC71.09683932
53CSNK1G11.09025535
54LATS21.05681237
55CAMK2B1.04186289
56RET1.04115291
57PINK11.03694619
58NME11.03270110
59MUSK1.03262847
60CAMK2D1.01399716
61LMTK20.97887488
62CAMKK20.96048936
63PAK30.92012329
64PRKCG0.91594594
65BRAF0.89513841
66MAP3K60.88658979
67PTK2B0.87253521
68PRKCE0.86872140
69FER0.86697576
70CSNK1G20.86118993
71VRK10.84701714
72GRK70.83785753
73CDK190.80383177
74PLK10.79986455
75PRKCH0.77027326
76AKT30.76389470
77KSR10.75612624
78PRPF4B0.75524689
79TIE10.74849164
80CAMK1G0.73387862
81CAMK2G0.71830437
82MOS0.69486396
83TRIM280.69214422
84EIF2AK30.68768918
85CAMKK10.68102135
86MAP2K10.67669989
87BCKDK0.65411199
88DYRK20.65408047
89PDPK10.64043508
90CSNK1A10.63107715
91SGK20.62908084
92CDK140.61797928
93SGK10.61168717
94FES0.61112263
95PRKCI0.59862143
96MAPK150.59356542
97CDC42BPA0.58138892
98NLK0.57701609
99MARK20.57524104
100ADRBK10.56502018
101CSNK1D0.56410442
102FGFR20.55721452
103PRKD20.54495886
104FGR0.54101539
105CDK180.53131467
106TAOK30.52669560
107STK38L0.52486808
108HIPK20.52443525
109CDK150.51906868
110BMPR1B0.51249572
111CAMK10.51157877
112ATR0.50252996
113CSNK1G30.48763148
114PRKCZ0.48559930
115RPS6KA50.47733889
116DYRK1A0.47281711
117STK110.47216903
118MAP2K60.46807179
119LIMK10.45877657
120PRKAA10.45819384
121DAPK10.45522647
122PRKACA0.45438763
123PDK10.44594435
124CHEK20.44288430
125TEC0.43791355
126PRKG10.43463497
127RPS6KB10.43327490
128SIK20.43100496
129CSNK1A1L0.43033294
130PRKCA0.42871668
131MAPKAPK30.42730127
132PLK30.42106799
133IRAK20.41829535
134ATM0.41424482
135TYRO30.41257371
136BCR0.41020249
137PRKCQ0.40836162
138MAPK100.40369654
139PKN10.40259146
140FRK0.40115820
141CDK11A0.39653317
142CDK30.39629279
143SGK30.39258908
144* RPS6KA30.38269950
145CSNK1E0.37640210
146STK30.37515229

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.01773439
2Nicotine addiction_Homo sapiens_hsa050333.00420962
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.64353310
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49461733
5Insulin secretion_Homo sapiens_hsa049112.48586256
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41613276
7Amphetamine addiction_Homo sapiens_hsa050312.32576760
8GABAergic synapse_Homo sapiens_hsa047272.31594510
9Circadian entrainment_Homo sapiens_hsa047132.27769030
10Long-term potentiation_Homo sapiens_hsa047202.26931023
11Glutamatergic synapse_Homo sapiens_hsa047242.21540524
12Taste transduction_Homo sapiens_hsa047422.15309845
13Collecting duct acid secretion_Homo sapiens_hsa049662.13026514
14Dopaminergic synapse_Homo sapiens_hsa047282.10426573
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10195384
16Olfactory transduction_Homo sapiens_hsa047402.10025259
17Morphine addiction_Homo sapiens_hsa050322.07625697
18Homologous recombination_Homo sapiens_hsa034401.95320240
19Serotonergic synapse_Homo sapiens_hsa047261.93251889
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86377742
21Salivary secretion_Homo sapiens_hsa049701.83673775
22Cholinergic synapse_Homo sapiens_hsa047251.76648891
23Cocaine addiction_Homo sapiens_hsa050301.76629580
24Fanconi anemia pathway_Homo sapiens_hsa034601.74648509
25Linoleic acid metabolism_Homo sapiens_hsa005911.72854096
26Long-term depression_Homo sapiens_hsa047301.63674495
27Selenocompound metabolism_Homo sapiens_hsa004501.62812515
28Gastric acid secretion_Homo sapiens_hsa049711.61826234
29Renin secretion_Homo sapiens_hsa049241.61736748
30Vibrio cholerae infection_Homo sapiens_hsa051101.61427394
31Basal transcription factors_Homo sapiens_hsa030221.56920549
32RNA degradation_Homo sapiens_hsa030181.56866782
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54519173
34Oxidative phosphorylation_Homo sapiens_hsa001901.51136433
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49279406
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48699121
37RNA polymerase_Homo sapiens_hsa030201.40925302
38GnRH signaling pathway_Homo sapiens_hsa049121.39153785
39Nitrogen metabolism_Homo sapiens_hsa009101.38761598
40Type II diabetes mellitus_Homo sapiens_hsa049301.38487631
41Calcium signaling pathway_Homo sapiens_hsa040201.34814386
42Oxytocin signaling pathway_Homo sapiens_hsa049211.34482733
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.32582913
44Cardiac muscle contraction_Homo sapiens_hsa042601.32422691
45Chemical carcinogenesis_Homo sapiens_hsa052041.31384869
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27433612
47Retinol metabolism_Homo sapiens_hsa008301.27392401
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25037008
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24041885
50Alzheimers disease_Homo sapiens_hsa050101.23025536
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18138618
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18121196
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16416030
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12261184
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12049709
56cAMP signaling pathway_Homo sapiens_hsa040241.07907730
57Gap junction_Homo sapiens_hsa045401.07422314
58Parkinsons disease_Homo sapiens_hsa050121.06713105
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.06535469
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.05232240
61Tryptophan metabolism_Homo sapiens_hsa003801.04292677
62Pancreatic secretion_Homo sapiens_hsa049721.03940290
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03233756
64Estrogen signaling pathway_Homo sapiens_hsa049151.01111882
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96665118
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94957011
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94030814
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90662822
69Sulfur relay system_Homo sapiens_hsa041220.90145455
70Thyroid hormone synthesis_Homo sapiens_hsa049180.90086363
71Melanogenesis_Homo sapiens_hsa049160.89302447
72One carbon pool by folate_Homo sapiens_hsa006700.87288948
73Protein export_Homo sapiens_hsa030600.85296286
74Glucagon signaling pathway_Homo sapiens_hsa049220.83350670
75Circadian rhythm_Homo sapiens_hsa047100.82147942
76* Dorso-ventral axis formation_Homo sapiens_hsa043200.79942502
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79909249
78ErbB signaling pathway_Homo sapiens_hsa040120.79172036
79Caffeine metabolism_Homo sapiens_hsa002320.77871001
80Glioma_Homo sapiens_hsa052140.76814168
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76539169
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72699764
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72294535
84Renin-angiotensin system_Homo sapiens_hsa046140.71752428
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.71745659
86Nucleotide excision repair_Homo sapiens_hsa034200.71699034
87Axon guidance_Homo sapiens_hsa043600.71452393
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71296481
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70977532
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68418416
91Dilated cardiomyopathy_Homo sapiens_hsa054140.66658310
92Choline metabolism in cancer_Homo sapiens_hsa052310.66218156
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.65594220
94Ovarian steroidogenesis_Homo sapiens_hsa049130.64959874
95Huntingtons disease_Homo sapiens_hsa050160.64654434
96Inositol phosphate metabolism_Homo sapiens_hsa005620.64506090
97Sulfur metabolism_Homo sapiens_hsa009200.62376053
98ABC transporters_Homo sapiens_hsa020100.60419676
99Prion diseases_Homo sapiens_hsa050200.58796299
100* Oocyte meiosis_Homo sapiens_hsa041140.58382733
101MAPK signaling pathway_Homo sapiens_hsa040100.58187104
102Hedgehog signaling pathway_Homo sapiens_hsa043400.57570962
103Propanoate metabolism_Homo sapiens_hsa006400.57498903
104Glycerolipid metabolism_Homo sapiens_hsa005610.57236205
105beta-Alanine metabolism_Homo sapiens_hsa004100.57145687
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56031947
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55155834
108Phototransduction_Homo sapiens_hsa047440.54434397
109Insulin signaling pathway_Homo sapiens_hsa049100.54104717
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.54010506
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.53853508
112Ras signaling pathway_Homo sapiens_hsa040140.53539266
113Regulation of autophagy_Homo sapiens_hsa041400.53105584
114Peroxisome_Homo sapiens_hsa041460.53052184
115Purine metabolism_Homo sapiens_hsa002300.53022106
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.50900303
117Arachidonic acid metabolism_Homo sapiens_hsa005900.50283091
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50250234
119Mismatch repair_Homo sapiens_hsa034300.49999124
120Type I diabetes mellitus_Homo sapiens_hsa049400.49073383
121Systemic lupus erythematosus_Homo sapiens_hsa053220.48075877
122RNA transport_Homo sapiens_hsa030130.45979669
123Ether lipid metabolism_Homo sapiens_hsa005650.45947762
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44279350
125Vitamin B6 metabolism_Homo sapiens_hsa007500.43697305
126Rheumatoid arthritis_Homo sapiens_hsa053230.43461214
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43113190
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42915973
129Metabolic pathways_Homo sapiens_hsa011000.42312292
130Renal cell carcinoma_Homo sapiens_hsa052110.42046608
131Basal cell carcinoma_Homo sapiens_hsa052170.40956820
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40062265
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39707475
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.39183790
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39148939
136Histidine metabolism_Homo sapiens_hsa003400.39087439
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38526610
138Tyrosine metabolism_Homo sapiens_hsa003500.36085421
139VEGF signaling pathway_Homo sapiens_hsa043700.35817792
140Phagosome_Homo sapiens_hsa041450.34706228
141Bile secretion_Homo sapiens_hsa049760.33699855
142Sphingolipid metabolism_Homo sapiens_hsa006000.32997238
143Butanoate metabolism_Homo sapiens_hsa006500.32800546
144Mineral absorption_Homo sapiens_hsa049780.31637304
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31489306
146Alcoholism_Homo sapiens_hsa050340.31315122

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