COX7A2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.54138300
2protein deneddylation (GO:0000338)5.46605869
3protein neddylation (GO:0045116)5.20770902
4nucleotide transmembrane transport (GO:1901679)4.26964923
5regulation of meiosis I (GO:0060631)4.06148635
6DNA methylation involved in gamete generation (GO:0043046)3.91525037
7cullin deneddylation (GO:0010388)3.84027052
8inositol phosphate catabolic process (GO:0071545)3.81119352
9ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.77233896
10protein polyglutamylation (GO:0018095)3.74951936
11centriole replication (GO:0007099)3.74638729
12phosphorylated carbohydrate dephosphorylation (GO:0046838)3.71036596
13inositol phosphate dephosphorylation (GO:0046855)3.71036596
14mismatch repair (GO:0006298)3.65308229
15protein prenylation (GO:0018342)3.56140785
16prenylation (GO:0097354)3.56140785
17adenosine metabolic process (GO:0046085)3.53987954
18one-carbon compound transport (GO:0019755)3.53972386
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.52394236
20positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.47315487
21negative regulation of osteoblast proliferation (GO:0033689)3.33050703
22negative regulation of response to food (GO:0032096)3.32376820
23negative regulation of appetite (GO:0032099)3.32376820
24polyol catabolic process (GO:0046174)3.30421782
25fusion of sperm to egg plasma membrane (GO:0007342)3.25753904
26erythrocyte maturation (GO:0043249)3.25544849
27male meiosis (GO:0007140)3.21588140
28response to misfolded protein (GO:0051788)3.18851826
29negative regulation of calcium ion transport into cytosol (GO:0010523)3.16658782
30meiotic cell cycle (GO:0051321)3.16104345
31protein K48-linked ubiquitination (GO:0070936)3.13876380
32regulation of female gonad development (GO:2000194)3.12393283
33positive regulation of endothelial cell differentiation (GO:0045603)3.12065093
34regulation of acyl-CoA biosynthetic process (GO:0050812)3.10974110
35regulation of response to osmotic stress (GO:0047484)3.09609822
36hemoglobin metabolic process (GO:0020027)3.09294756
37negative regulation of heart rate (GO:0010459)3.09195836
38base-excision repair, AP site formation (GO:0006285)3.02678515
39regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.96744133
40regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.96744133
41pyrimidine dimer repair (GO:0006290)2.93561269
42phosphorelay signal transduction system (GO:0000160)2.90945594
43positive regulation of Rho protein signal transduction (GO:0035025)2.90274370
44positive regulation of hormone biosynthetic process (GO:0046886)2.90264414
45binding of sperm to zona pellucida (GO:0007339)2.90004313
46relaxation of smooth muscle (GO:0044557)2.88116229
47developmental pigmentation (GO:0048066)2.87986255
48tyrosine metabolic process (GO:0006570)2.87625695
49auditory receptor cell differentiation (GO:0042491)2.87074640
50regulation of cofactor metabolic process (GO:0051193)2.85368519
51regulation of coenzyme metabolic process (GO:0051196)2.85368519
52regulation of steroid hormone secretion (GO:2000831)2.83832238
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.83275107
54negative regulation of norepinephrine secretion (GO:0010700)2.82853121
55L-methionine salvage (GO:0071267)2.81668970
56L-methionine biosynthetic process (GO:0071265)2.81668970
57amino acid salvage (GO:0043102)2.81668970
58ketone body metabolic process (GO:1902224)2.80508412
59plasma membrane fusion (GO:0045026)2.80050167
60synapsis (GO:0007129)2.79451523
61regulation of DNA methylation (GO:0044030)2.77688945
62signal peptide processing (GO:0006465)2.77282050
63methionine metabolic process (GO:0006555)2.76275483
64thrombin receptor signaling pathway (GO:0070493)2.75112622
65serotonin receptor signaling pathway (GO:0007210)2.73491406
66very long-chain fatty acid metabolic process (GO:0000038)2.72399236
67sleep (GO:0030431)2.71404837
68sperm-egg recognition (GO:0035036)2.70426027
69negative regulation of cation channel activity (GO:2001258)2.69817105
70oocyte development (GO:0048599)2.69402848
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.69136253
72cellular ketone body metabolic process (GO:0046950)2.69009849
73platelet dense granule organization (GO:0060155)2.68634675
74regulation of germinal center formation (GO:0002634)2.66290985
75positive regulation of protein homodimerization activity (GO:0090073)2.65735996
76neurotransmitter-gated ion channel clustering (GO:0072578)2.65718172
77purine deoxyribonucleotide catabolic process (GO:0009155)2.64611393
78misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.64249321
79negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.64245725
80lipoxygenase pathway (GO:0019372)2.63240108
81regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.62803233
82gene silencing by RNA (GO:0031047)2.61239919
83female gamete generation (GO:0007292)2.61107305
84ribonucleoprotein complex disassembly (GO:0032988)2.60612447
85fatty acid elongation (GO:0030497)2.60297816
86multicellular organism reproduction (GO:0032504)2.60004038
87regulation of vacuole organization (GO:0044088)2.59281400
88mitochondrial calcium ion transport (GO:0006851)2.58678736
89acrosome assembly (GO:0001675)2.58311700
90regulation of female receptivity (GO:0045924)2.58199292
91female gonad development (GO:0008585)2.52836483
92neuron fate determination (GO:0048664)2.51322167
93oxidative demethylation (GO:0070989)2.50700588
94peptidyl-glutamic acid modification (GO:0018200)2.50654092
95organelle disassembly (GO:1903008)2.49548357
96deoxyribose phosphate catabolic process (GO:0046386)2.49089701
97regulation of male gonad development (GO:2000018)2.48776000
98centriole assembly (GO:0098534)2.48418304
99regulation of memory T cell differentiation (GO:0043380)2.45104029
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43137694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.27726744
2TAF15_26573619_Chip-Seq_HEK293_Human3.33097245
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.27626831
4GBX2_23144817_ChIP-Seq_PC3_Human3.24797437
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23106832
6IRF1_19129219_ChIP-ChIP_H3396_Human3.17017914
7POU3F2_20337985_ChIP-ChIP_501MEL_Human3.14422387
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81674363
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70945634
10HTT_18923047_ChIP-ChIP_STHdh_Human2.26636484
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.15544293
12EWS_26573619_Chip-Seq_HEK293_Human2.03392315
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01939254
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95867284
15FUS_26573619_Chip-Seq_HEK293_Human1.94636220
16CBP_20019798_ChIP-Seq_JUKART_Human1.83838046
17IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.83838046
18ZNF274_21170338_ChIP-Seq_K562_Hela1.82745302
19ER_23166858_ChIP-Seq_MCF-7_Human1.82565856
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80313092
21BCAT_22108803_ChIP-Seq_LS180_Human1.75908098
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75332695
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69322561
24AR_25329375_ChIP-Seq_VCAP_Human1.66297738
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64939240
26SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64823754
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64345886
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63405840
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61048940
30P300_19829295_ChIP-Seq_ESCs_Human1.57913793
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57587353
32IGF1R_20145208_ChIP-Seq_DFB_Human1.54653649
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53097587
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53014874
35SMAD4_21799915_ChIP-Seq_A2780_Human1.52939607
36TP53_22573176_ChIP-Seq_HFKS_Human1.52453040
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48466139
38VDR_22108803_ChIP-Seq_LS180_Human1.48358704
39VDR_23849224_ChIP-Seq_CD4+_Human1.47806507
40TAL1_26923725_Chip-Seq_HPCs_Mouse1.45877337
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.44773305
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41890133
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40975705
44STAT3_23295773_ChIP-Seq_U87_Human1.40592649
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40337899
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40075345
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40044688
48ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37866381
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32143011
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.30720135
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29716045
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.28817940
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28137819
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.27191475
55TCF4_23295773_ChIP-Seq_U87_Human1.24820285
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24703810
57ELK1_19687146_ChIP-ChIP_HELA_Human1.24212373
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20311373
59JUN_21703547_ChIP-Seq_K562_Human1.19497286
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16277710
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.15307209
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12638427
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11118300
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.10909736
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10662451
66NANOG_19829295_ChIP-Seq_ESCs_Human1.10328462
67SOX2_19829295_ChIP-Seq_ESCs_Human1.10328462
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.09486185
69TCF4_22108803_ChIP-Seq_LS180_Human1.09331783
70NANOG_20526341_ChIP-Seq_ESCs_Human1.08739698
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08705638
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.08366421
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.08021666
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08021666
75GATA3_26560356_Chip-Seq_TH1_Human1.07369610
76MYC_18940864_ChIP-ChIP_HL60_Human1.07158827
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05185703
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04944494
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.04395651
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.04326807
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.03096116
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02971325
83P53_22387025_ChIP-Seq_ESCs_Mouse1.01046653
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00840437
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00560044
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00422433
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99892775
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.98989777
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98348342
90ERG_20517297_ChIP-Seq_VCAP_Human0.96514968
91SMRT_27268052_Chip-Seq_Bcells_Human0.96325332
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95477874
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94986556
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.94653281
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.94236578
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94091120
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93625491
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.93280129
99GF1B_26923725_Chip-Seq_HPCs_Mouse0.92424711
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91884195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.07918366
2MP0005394_taste/olfaction_phenotype3.87474654
3MP0005499_abnormal_olfactory_system3.87474654
4MP0008789_abnormal_olfactory_epithelium3.62594791
5MP0008877_abnormal_DNA_methylation3.36937466
6MP0001529_abnormal_vocalization3.26156565
7MP0000372_irregular_coat_pigmentation3.20870572
8MP0002102_abnormal_ear_morphology3.16739938
9MP0005464_abnormal_platelet_physiology3.13684859
10MP0008058_abnormal_DNA_repair2.73593456
11MP0006292_abnormal_olfactory_placode2.56219648
12MP0004142_abnormal_muscle_tone2.30252583
13MP0003195_calcinosis2.17437272
14MP0002909_abnormal_adrenal_gland2.03501718
15MP0008872_abnormal_physiological_respon2.01048382
16MP0001905_abnormal_dopamine_level1.91519913
17MP0003879_abnormal_hair_cell1.91383206
18MP0002234_abnormal_pharynx_morphology1.88970089
19MP0000015_abnormal_ear_pigmentation1.81095882
20MP0003656_abnormal_erythrocyte_physiolo1.78400321
21MP0005410_abnormal_fertilization1.78006758
22MP0005167_abnormal_blood-brain_barrier1.73876608
23MP0002876_abnormal_thyroid_physiology1.71853163
24MP0002090_abnormal_vision1.64965977
25MP0005395_other_phenotype1.60449157
26MP0008995_early_reproductive_senescence1.53942079
27MP0005646_abnormal_pituitary_gland1.51083710
28MP0004147_increased_porphyrin_level1.47648562
29MP0005551_abnormal_eye_electrophysiolog1.47605414
30MP0005174_abnormal_tail_pigmentation1.45929358
31MP0000465_gastrointestinal_hemorrhage1.38302304
32MP0008775_abnormal_heart_ventricle1.37806243
33MP0005248_abnormal_Harderian_gland1.37283296
34MP0009046_muscle_twitch1.35708983
35MP0002095_abnormal_skin_pigmentation1.34265902
36MP0003890_abnormal_embryonic-extraembry1.33933618
37MP0005645_abnormal_hypothalamus_physiol1.33421224
38MP0002210_abnormal_sex_determination1.31559345
39MP0001485_abnormal_pinna_reflex1.30533701
40MP0006276_abnormal_autonomic_nervous1.29589843
41MP0001984_abnormal_olfaction1.25324980
42MP0001929_abnormal_gametogenesis1.23591443
43MP0003786_premature_aging1.23408208
44MP0005636_abnormal_mineral_homeostasis1.22122152
45MP0001968_abnormal_touch/_nociception1.22006943
46MP0006036_abnormal_mitochondrial_physio1.21948387
47MP0005075_abnormal_melanosome_morpholog1.21223591
48MP0001756_abnormal_urination1.18539778
49MP0003186_abnormal_redox_activity1.17875084
50MP0005171_absent_coat_pigmentation1.16233081
51MP0001324_abnormal_eye_pigmentation1.15863526
52MP0003136_yellow_coat_color1.11566880
53MP0003646_muscle_fatigue1.11334884
54MP0002272_abnormal_nervous_system1.10168813
55MP0000569_abnormal_digit_pigmentation1.09604605
56MP0005647_abnormal_sex_gland1.08546423
57MP0003119_abnormal_digestive_system1.04760630
58MP0000653_abnormal_sex_gland1.04550405
59MP0009780_abnormal_chondrocyte_physiolo1.03146693
60MP0009765_abnormal_xenobiotic_induced1.00589251
61MP0003698_abnormal_male_reproductive0.98901596
62MP0003878_abnormal_ear_physiology0.98758556
63MP0005377_hearing/vestibular/ear_phenot0.98758556
64MP0002736_abnormal_nociception_after0.98597952
65MP0005083_abnormal_biliary_tract0.95637422
66MP0005379_endocrine/exocrine_gland_phen0.95606962
67MP0010094_abnormal_chromosome_stability0.95267717
68MP0000631_abnormal_neuroendocrine_gland0.94452535
69MP0002229_neurodegeneration0.94264122
70MP0005332_abnormal_amino_acid0.93468788
71MP0005671_abnormal_response_to0.92649251
72MP0004924_abnormal_behavior0.91006091
73MP0005386_behavior/neurological_phenoty0.91006091
74MP0008004_abnormal_stomach_pH0.89768061
75MP0002139_abnormal_hepatobiliary_system0.84609125
76MP0005253_abnormal_eye_physiology0.84472524
77MP0002161_abnormal_fertility/fecundity0.83621776
78MP0003699_abnormal_female_reproductive0.83264462
79MP0002067_abnormal_sensory_capabilities0.83083608
80MP0001145_abnormal_male_reproductive0.82699557
81MP0001293_anophthalmia0.81593994
82MP0004859_abnormal_synaptic_plasticity0.81215358
83MP0008932_abnormal_embryonic_tissue0.81032717
84MP0001486_abnormal_startle_reflex0.80929622
85MP0005408_hypopigmentation0.80091771
86MP0002837_dystrophic_cardiac_calcinosis0.78801200
87MP0003122_maternal_imprinting0.78780225
88MP0003121_genomic_imprinting0.77923131
89MP0001765_abnormal_ion_homeostasis0.77824875
90MP0000230_abnormal_systemic_arterial0.76995116
91MP0003183_abnormal_peptide_metabolism0.76528305
92MP0009745_abnormal_behavioral_response0.74036996
93MP0004043_abnormal_pH_regulation0.72780811
94MP0005058_abnormal_lysosome_morphology0.70039277
95MP0009763_increased_sensitivity_to0.69336078
96MP0006035_abnormal_mitochondrial_morpho0.68789020
97MP0000639_abnormal_adrenal_gland0.68688775
98MP0006072_abnormal_retinal_apoptosis0.67736360
99MP0005367_renal/urinary_system_phenotyp0.66607043
100MP0000516_abnormal_urinary_system0.66607043

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)4.62127534
2Petechiae (HP:0000967)4.47526499
3Double outlet right ventricle (HP:0001719)4.14940180
4Congenital malformation of the right heart (HP:0011723)4.14940180
5Oligodactyly (hands) (HP:0001180)3.82702403
6Abnormal gallbladder physiology (HP:0012438)3.75020886
7Cholecystitis (HP:0001082)3.75020886
8Prolonged bleeding time (HP:0003010)3.56077525
9Aplasia/hypoplasia of the uterus (HP:0008684)3.50394048
10Renal cortical cysts (HP:0000803)3.05483107
11Hypophosphatemic rickets (HP:0004912)3.01705193
12Upper limb muscle weakness (HP:0003484)2.98537833
13Purpura (HP:0000979)2.97268777
14Abnormality of abdominal situs (HP:0011620)2.94729851
15Abdominal situs inversus (HP:0003363)2.94729851
16Menorrhagia (HP:0000132)2.93481823
17Generalized aminoaciduria (HP:0002909)2.80568255
183-Methylglutaconic aciduria (HP:0003535)2.79917651
19Increased mean platelet volume (HP:0011877)2.75688216
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.63969679
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.63969679
22Gingival bleeding (HP:0000225)2.61235144
23Nephronophthisis (HP:0000090)2.57780574
24Abolished electroretinogram (ERG) (HP:0000550)2.54245943
25Abnormal platelet volume (HP:0011876)2.53003392
26Renal Fanconi syndrome (HP:0001994)2.52275385
27Abnormality of the renal cortex (HP:0011035)2.47878602
28Median cleft lip (HP:0000161)2.47560082
29Abnormal auditory evoked potentials (HP:0006958)2.47284083
30Epistaxis (HP:0000421)2.46106460
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.44391339
32Hypoplasia of the fovea (HP:0007750)2.43939475
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.43939475
34Intestinal atresia (HP:0011100)2.35281460
35Impaired vibration sensation in the lower limbs (HP:0002166)2.29648071
36Hypoplasia of the uterus (HP:0000013)2.28683278
37Hyperlipoproteinemia (HP:0010980)2.28401779
38Anhidrosis (HP:0000970)2.24329233
39Tongue fasciculations (HP:0001308)2.24149586
40Oligodactyly (HP:0012165)2.23693360
41Hypoplasia of the thymus (HP:0000778)2.21809338
42Poikilocytosis (HP:0004447)2.19126717
43Supernumerary spleens (HP:0009799)2.18870091
44Abnormality of the fovea (HP:0000493)2.18836014
45Medial flaring of the eyebrow (HP:0010747)2.16972837
46Abnormality of midbrain morphology (HP:0002418)2.16920446
47Molar tooth sign on MRI (HP:0002419)2.16920446
48Gaze-evoked nystagmus (HP:0000640)2.16333166
49Growth hormone deficiency (HP:0000824)2.15183857
50Abnormal platelet function (HP:0011869)2.14474706
51Impaired platelet aggregation (HP:0003540)2.14474706
52Male infertility (HP:0003251)2.11965477
53Abnormality of the anterior horn cell (HP:0006802)2.10421204
54Degeneration of anterior horn cells (HP:0002398)2.10421204
55Abnormality of renal resorption (HP:0011038)2.10000171
56Enlarged kidneys (HP:0000105)2.09037519
57Exertional dyspnea (HP:0002875)2.04963352
58Aplasia/Hypoplasia of the macula (HP:0008059)2.02996211
59Urinary urgency (HP:0000012)2.02543013
60Truncus arteriosus (HP:0001660)1.99055181
61Stillbirth (HP:0003826)1.98180301
62Short tibia (HP:0005736)1.97660306
63Postural tremor (HP:0002174)1.96220669
64Decreased central vision (HP:0007663)1.94797845
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.94234179
66Abnormality of alanine metabolism (HP:0010916)1.92293651
67Hyperalaninemia (HP:0003348)1.92293651
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92293651
69Poor suck (HP:0002033)1.91062686
70Abnormal sex determination (HP:0012244)1.90915147
71Sex reversal (HP:0012245)1.90915147
72Severe visual impairment (HP:0001141)1.89938463
73Dyschromatopsia (HP:0007641)1.88909432
74Papillary thyroid carcinoma (HP:0002895)1.85597117
75Methylmalonic acidemia (HP:0002912)1.84601667
76Albinism (HP:0001022)1.83746547
77Osteomalacia (HP:0002749)1.83694948
78Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82801417
79Muscle fibrillation (HP:0010546)1.82364873
80Abnormality of the renal medulla (HP:0100957)1.82042692
81Infertility (HP:0000789)1.81627884
82Severe combined immunodeficiency (HP:0004430)1.78859133
83Poor head control (HP:0002421)1.77916897
84Abnormality of the corticospinal tract (HP:0002492)1.73923704
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73914568
86Lower limb hyperreflexia (HP:0002395)1.69502579
87Fatigue (HP:0012378)1.69405157
88Hepatic necrosis (HP:0002605)1.69127670
89Cleft eyelid (HP:0000625)1.69105820
90Abnormal pupillary function (HP:0007686)1.67881131
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67770039
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67770039
93Nausea (HP:0002018)1.66087719
94Sensory axonal neuropathy (HP:0003390)1.64226467
95Ankle clonus (HP:0011448)1.64036499
96Nephrogenic diabetes insipidus (HP:0009806)1.63778528
97Pancreatic islet-cell hyperplasia (HP:0004510)1.61659125
98Failure to thrive in infancy (HP:0001531)1.61562711
99Acanthocytosis (HP:0001927)1.60643420
100Brittle hair (HP:0002299)1.59486736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.36173507
2WNK34.72088849
3TAOK34.28781045
4MAP3K43.26312214
5EIF2AK12.81619287
6MUSK2.67242531
7ZAK2.58482970
8MAP2K72.48772500
9TXK2.39793257
10MST42.31258888
11PIK3CG2.19457338
12TNIK1.72467292
13PTK2B1.68531485
14NEK61.60833677
15ARAF1.53130249
16FRK1.52968316
17BTK1.52032775
18TEC1.46768976
19KDR1.40849641
20CSNK1G31.32397704
21ERBB31.27017715
22PLK21.26094875
23MYLK1.25927622
24CSNK1G11.20118800
25CSNK1A1L1.08751316
26NUAK11.05869596
27CSNK1G21.04362417
28CSF1R1.01881273
29PNCK1.01494251
30BMPR20.98728625
31GRK10.97931856
32TRIM280.97098020
33PAK30.96648159
34TTK0.94734170
35STK240.93705913
36MAP3K50.93656888
37ADRBK20.93430644
38MAP2K40.92491799
39PDK20.91537402
40PLK30.91401538
41GRK50.89609266
42MAP3K90.80937212
43MARK30.78095219
44CDK90.77474103
45BRSK10.71676155
46STK30.69434236
47FER0.68826220
48VRK10.67273468
49INSRR0.66126250
50FES0.66051867
51CDC70.65895173
52RAF10.65182789
53DYRK30.64658530
54MAPK130.63840039
55PRKG10.62512475
56BRSK20.62196729
57CSNK1D0.60100265
58IRAK20.59460202
59AURKA0.55517701
60HCK0.53603570
61MAP3K120.52943437
62BRAF0.52022505
63ACVR1B0.51817405
64ATR0.51743238
65PKN10.51724984
66CAMK2A0.51582849
67PRKACA0.51500908
68WNK10.51035240
69LYN0.49855307
70PIM10.48185447
71CAMK1G0.47512459
72IGF1R0.46483988
73TIE10.46214753
74TAF10.46126199
75PAK10.45450797
76VRK20.44235140
77DAPK10.42699371
78PRKCI0.42621931
79TNK20.42614636
80MET0.40901526
81BMPR1B0.40426439
82MAPKAPK30.39717124
83NTRK30.39365384
84WEE10.39082583
85EIF2AK20.38550918
86PRKACB0.38241020
87CSNK1E0.37468358
88ITK0.36640281
89TRPM70.36447241
90PRKCE0.36442969
91DAPK20.35219008
92EGFR0.34912942
93PRKACG0.34505929
94JAK30.33573292
95PRKCA0.33304489
96GRK60.33201561
97BMX0.32619483
98NTRK20.31913883
99CDK70.31115224
100STK38L0.30889954

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.73985423
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.91716747
3Basal transcription factors_Homo sapiens_hsa030222.79175102
4Collecting duct acid secretion_Homo sapiens_hsa049662.58226871
5Fatty acid elongation_Homo sapiens_hsa000622.57855857
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.14354581
7Homologous recombination_Homo sapiens_hsa034402.12463072
8Mismatch repair_Homo sapiens_hsa034302.11647448
9Non-homologous end-joining_Homo sapiens_hsa034502.11319827
10Protein export_Homo sapiens_hsa030602.05329078
11Regulation of autophagy_Homo sapiens_hsa041401.97991018
12Oxidative phosphorylation_Homo sapiens_hsa001901.94394633
13Selenocompound metabolism_Homo sapiens_hsa004501.92721349
14Phototransduction_Homo sapiens_hsa047441.87915171
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81394279
16Fanconi anemia pathway_Homo sapiens_hsa034601.75777335
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74976765
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.71479560
19GABAergic synapse_Homo sapiens_hsa047271.71352518
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67124429
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58343699
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57558691
23Synaptic vesicle cycle_Homo sapiens_hsa047211.53045803
24RNA degradation_Homo sapiens_hsa030181.53005668
25Nicotine addiction_Homo sapiens_hsa050331.51070114
26Arachidonic acid metabolism_Homo sapiens_hsa005901.45890440
27Oocyte meiosis_Homo sapiens_hsa041141.41886757
28Olfactory transduction_Homo sapiens_hsa047401.40534808
29Linoleic acid metabolism_Homo sapiens_hsa005911.36357304
30Parkinsons disease_Homo sapiens_hsa050121.36108527
31Type I diabetes mellitus_Homo sapiens_hsa049401.32714742
32Ovarian steroidogenesis_Homo sapiens_hsa049131.29811841
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28470592
34Ether lipid metabolism_Homo sapiens_hsa005651.27367803
35Caffeine metabolism_Homo sapiens_hsa002321.26378139
36Butanoate metabolism_Homo sapiens_hsa006501.25312825
37Serotonergic synapse_Homo sapiens_hsa047261.24383571
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22522646
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22295655
40Nucleotide excision repair_Homo sapiens_hsa034201.21741738
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21204435
42Propanoate metabolism_Homo sapiens_hsa006401.20839779
43Huntingtons disease_Homo sapiens_hsa050161.17543531
44Tyrosine metabolism_Homo sapiens_hsa003501.17462529
45RNA polymerase_Homo sapiens_hsa030201.13940969
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13484611
47Peroxisome_Homo sapiens_hsa041461.08907499
48Taste transduction_Homo sapiens_hsa047421.07601196
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07286711
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01951209
51Morphine addiction_Homo sapiens_hsa050320.99611919
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98454885
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98280411
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91878127
55Purine metabolism_Homo sapiens_hsa002300.90775701
56Sulfur metabolism_Homo sapiens_hsa009200.90301620
57Cell cycle_Homo sapiens_hsa041100.88454336
58Vibrio cholerae infection_Homo sapiens_hsa051100.85664146
59Platelet activation_Homo sapiens_hsa046110.85408059
60Circadian rhythm_Homo sapiens_hsa047100.83661772
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82156970
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81945304
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80077268
64Rheumatoid arthritis_Homo sapiens_hsa053230.79306168
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78849994
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78589352
67One carbon pool by folate_Homo sapiens_hsa006700.76663378
68Sphingolipid metabolism_Homo sapiens_hsa006000.73442451
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72831146
70RNA transport_Homo sapiens_hsa030130.71356650
71beta-Alanine metabolism_Homo sapiens_hsa004100.68648441
72Phenylalanine metabolism_Homo sapiens_hsa003600.67656755
73Hematopoietic cell lineage_Homo sapiens_hsa046400.67405958
74Fat digestion and absorption_Homo sapiens_hsa049750.66661171
75p53 signaling pathway_Homo sapiens_hsa041150.59307955
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.58712364
77Metabolic pathways_Homo sapiens_hsa011000.58447416
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57797220
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56990558
80Pyrimidine metabolism_Homo sapiens_hsa002400.56198014
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.54205808
82Nitrogen metabolism_Homo sapiens_hsa009100.53657498
83Pyruvate metabolism_Homo sapiens_hsa006200.53599879
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52492176
85Alzheimers disease_Homo sapiens_hsa050100.52355640
86Folate biosynthesis_Homo sapiens_hsa007900.49919273
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46296336
88Cardiac muscle contraction_Homo sapiens_hsa042600.44480778
89Base excision repair_Homo sapiens_hsa034100.43114027
90Steroid biosynthesis_Homo sapiens_hsa001000.39005265
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35477474
92Inositol phosphate metabolism_Homo sapiens_hsa005620.35421090
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35333934
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34167838
95Starch and sucrose metabolism_Homo sapiens_hsa005000.32122721
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28354520
97Glutamatergic synapse_Homo sapiens_hsa047240.26537582
98Shigellosis_Homo sapiens_hsa051310.26345398
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25548839
100Phagosome_Homo sapiens_hsa041450.24804294

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