COX6A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.21866007
2ATP synthesis coupled proton transport (GO:0015986)8.63476672
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.63476672
4* respiratory electron transport chain (GO:0022904)7.00078047
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.97723085
6* electron transport chain (GO:0022900)6.82193751
7oxidative phosphorylation (GO:0006119)6.26130988
8ATP biosynthetic process (GO:0006754)5.13708671
9protein complex biogenesis (GO:0070271)4.88117665
10chaperone-mediated protein transport (GO:0072321)4.76913508
11regulation of mitochondrial translation (GO:0070129)4.67689409
12ribosomal small subunit assembly (GO:0000028)4.62720554
13mitochondrial respiratory chain complex assembly (GO:0033108)4.52016057
14purine nucleoside triphosphate biosynthetic process (GO:0009145)4.50270453
15purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.47464947
16cytochrome complex assembly (GO:0017004)4.40063104
17regulation of oxidative phosphorylation (GO:0002082)4.26126512
18termination of RNA polymerase III transcription (GO:0006386)4.24327185
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.24327185
20* hydrogen ion transmembrane transport (GO:1902600)4.23140418
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.16985139
22NADH dehydrogenase complex assembly (GO:0010257)4.16985139
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16985139
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.04525303
25ribonucleoside triphosphate biosynthetic process (GO:0009201)4.04274911
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.00576878
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.00308804
28negative regulation of ligase activity (GO:0051352)4.00308804
29deoxyribose phosphate biosynthetic process (GO:0046385)3.82297361
302-deoxyribonucleotide biosynthetic process (GO:0009265)3.82297361
31anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.81017569
32proteasome assembly (GO:0043248)3.79688573
33cellular response to oxygen radical (GO:0071450)3.78788158
34removal of superoxide radicals (GO:0019430)3.78788158
35cellular response to superoxide (GO:0071451)3.78788158
36nucleoside triphosphate biosynthetic process (GO:0009142)3.73660390
37hydrogen peroxide catabolic process (GO:0042744)3.70516522
38inner mitochondrial membrane organization (GO:0007007)3.69464796
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.68156313
40heme biosynthetic process (GO:0006783)3.67465033
41* proton transport (GO:0015992)3.65776448
42heart process (GO:0003015)3.61042751
43heart contraction (GO:0060047)3.61042751
44nucleoside diphosphate biosynthetic process (GO:0009133)3.59329712
45* hydrogen transport (GO:0006818)3.58951637
46tricarboxylic acid cycle (GO:0006099)3.57803814
47maturation of SSU-rRNA (GO:0030490)3.57660849
48translational elongation (GO:0006414)3.55712606
49positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55472256
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.55312371
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.55312371
52rRNA modification (GO:0000154)3.51684244
53purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.51119782
54purine nucleoside monophosphate biosynthetic process (GO:0009127)3.51119782
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.50258837
56cellular ketone body metabolic process (GO:0046950)3.48414057
57respiratory chain complex IV assembly (GO:0008535)3.45357097
58aerobic respiration (GO:0009060)3.45029794
59mitochondrial transport (GO:0006839)3.44416044
60pseudouridine synthesis (GO:0001522)3.42915314
61aldehyde catabolic process (GO:0046185)3.41743805
62ribosomal large subunit biogenesis (GO:0042273)3.40061303
63establishment of integrated proviral latency (GO:0075713)3.38497507
64positive regulation of ligase activity (GO:0051351)3.37327828
65protein targeting to mitochondrion (GO:0006626)3.36081088
66heme metabolic process (GO:0042168)3.35378574
67nucleobase-containing small molecule interconversion (GO:0015949)3.32763992
68translational initiation (GO:0006413)3.27941984
69protein-cofactor linkage (GO:0018065)3.27104171
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26766197
71cytidine catabolic process (GO:0006216)3.25945204
72cytidine deamination (GO:0009972)3.25945204
73cytidine metabolic process (GO:0046087)3.25945204
74GTP biosynthetic process (GO:0006183)3.23865775
75protein deneddylation (GO:0000338)3.23452942
76regulation of cellular amino acid metabolic process (GO:0006521)3.21875693
77DNA deamination (GO:0045006)3.21499916
78cellular component biogenesis (GO:0044085)3.21389220
79negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.21194627
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21023833
81spliceosomal snRNP assembly (GO:0000387)3.21012248
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20242222
83establishment of protein localization to mitochondrion (GO:0072655)3.20195557
84protein neddylation (GO:0045116)3.19996854
85GDP-mannose metabolic process (GO:0019673)3.19304547
86regulation of cellular respiration (GO:0043457)3.18963562
87viral life cycle (GO:0019058)3.17958769
88regulation of ubiquitin-protein transferase activity (GO:0051438)3.16884231
89regulation of cellular amine metabolic process (GO:0033238)3.16397596
90cellular protein complex disassembly (GO:0043624)3.13827476
91cullin deneddylation (GO:0010388)3.13122546
92water-soluble vitamin biosynthetic process (GO:0042364)3.09856322
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08100475
94intracellular protein transmembrane import (GO:0044743)3.07652394
95deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.07625196
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06091452
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06091452
98hydrogen peroxide metabolic process (GO:0042743)3.05381872
99deoxyribonucleotide biosynthetic process (GO:0009263)3.04920188
100regulation of ligase activity (GO:0051340)3.03256167
101nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03076015
102protein localization to mitochondrion (GO:0070585)3.03074786
103ribonucleoside monophosphate biosynthetic process (GO:0009156)3.01225881
104cotranslational protein targeting to membrane (GO:0006613)3.00138711
105protein targeting to ER (GO:0045047)3.00133721
106viral transcription (GO:0019083)2.99929693
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98132532
108ketone body metabolic process (GO:1902224)2.97922132
109establishment of protein localization to mitochondrial membrane (GO:0090151)2.97710795
110nucleoside monophosphate biosynthetic process (GO:0009124)2.96463422
111negative regulation of mitochondrion organization (GO:0010823)2.95210683
112purine ribonucleoside biosynthetic process (GO:0046129)2.94293412
113purine nucleoside biosynthetic process (GO:0042451)2.94293412
114NADH metabolic process (GO:0006734)2.93599527
115metallo-sulfur cluster assembly (GO:0031163)2.92615173
116iron-sulfur cluster assembly (GO:0016226)2.92615173
117negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91796004
118porphyrin-containing compound biosynthetic process (GO:0006779)2.91330166
119translation (GO:0006412)2.90808211
1207-methylguanosine mRNA capping (GO:0006370)2.89335550
121antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89320063
122protein localization to endoplasmic reticulum (GO:0070972)2.89246143
123ribosomal small subunit biogenesis (GO:0042274)2.88666988
124sequestering of actin monomers (GO:0042989)2.88209130
125establishment of viral latency (GO:0019043)2.87884245
126DNA damage response, detection of DNA damage (GO:0042769)2.87484099
127RNA capping (GO:0036260)2.85657704
1287-methylguanosine RNA capping (GO:0009452)2.85657704
129translational termination (GO:0006415)2.85626608
130response to oxygen radical (GO:0000305)2.85448056
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85201791
132UTP biosynthetic process (GO:0006228)2.84015017
133response to superoxide (GO:0000303)2.83825308
134DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.81522737
135chromatin remodeling at centromere (GO:0031055)2.80667642
136ADP metabolic process (GO:0046031)2.79407027
137protoporphyrinogen IX biosynthetic process (GO:0006782)2.79348467
138regulation of metalloenzyme activity (GO:0048552)2.77134836
139signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75752460
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75752460
141establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74645897
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74395692
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74395692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.48212735
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09641716
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05251069
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54487149
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.30390251
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.28762027
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19613286
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15485767
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.14107508
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.92318292
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.90865978
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.80518467
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67342115
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55360759
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.50424283
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44770115
17CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.37484365
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.31527858
19E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31096611
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30053575
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.27812782
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25781620
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24885725
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20530606
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15208807
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14845383
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.00952110
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99539918
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98850103
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95372841
31DCP1A_22483619_ChIP-Seq_HELA_Human1.90237713
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89581186
33XRN2_22483619_ChIP-Seq_HELA_Human1.84865938
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79253986
35VDR_23849224_ChIP-Seq_CD4+_Human1.77306032
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70929554
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63709653
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63684976
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62475451
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61840206
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61533980
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.61223051
43* GABP_19822575_ChIP-Seq_HepG2_Human1.60784811
44MYC_18940864_ChIP-ChIP_HL60_Human1.59032225
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58349777
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57681615
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51918652
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51080372
49HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49891744
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48583766
51CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47827144
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41091620
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35728064
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32432821
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30245317
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29457525
57TTF2_22483619_ChIP-Seq_HELA_Human1.28806611
58* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28450603
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27813166
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27571213
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27391862
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25874162
63KDM5A_27292631_Chip-Seq_BREAST_Human1.24847346
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24171361
65FOXP3_21729870_ChIP-Seq_TREG_Human1.23262382
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21321125
67* ELK1_22589737_ChIP-Seq_MCF10A_Human1.20828698
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.20727540
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20209524
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19650835
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18717104
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18608365
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18511809
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17167088
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15404508
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15362023
77* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14343995
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12909341
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11140896
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.11095373
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10822444
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10477532
83TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10178698
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09885103
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09523630
86ELK1_19687146_ChIP-ChIP_HELA_Human1.09506226
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08212892
88BCL6_27268052_Chip-Seq_Bcells_Human1.05473960
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04994658
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04900042
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04086136
92* CTCF_26484167_Chip-Seq_Bcells_Mouse1.03442274
93E2F7_22180533_ChIP-Seq_HELA_Human1.02811800
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02753553
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.02634837
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.99806805
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98563120
98* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98431195
99* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97459096
100CTCF_20526341_ChIP-Seq_ESCs_Human0.96434869
101E2F1_21310950_ChIP-Seq_MCF-7_Human0.95381251
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94356505
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93347637
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93307164
105* NANOG_16153702_ChIP-ChIP_HESCs_Human0.92310118
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92117872
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92117456
108AR_21909140_ChIP-Seq_LNCAP_Human0.90917307
109ZNF274_21170338_ChIP-Seq_K562_Hela0.90786471
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90618469
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90595303
112ZNF263_19887448_ChIP-Seq_K562_Human0.90413824
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90156406
114BCOR_27268052_Chip-Seq_Bcells_Human0.89802838
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89368120
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89137769
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88813711
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88501982
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88429722
120ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87713453
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87643670
122* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87322284
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87116743
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85706993
125* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83603565
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82093856
127HTT_18923047_ChIP-ChIP_STHdh_Human0.81848181
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81757580
129VDR_22108803_ChIP-Seq_LS180_Human0.80977884
130NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80422413
131TP53_22573176_ChIP-Seq_HFKS_Human0.79830466
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77763699
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.77191311
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.76415545
135ELF5_23300383_ChIP-Seq_T47D_Human0.67683187
136ERG_20517297_ChIP-Seq_VCAP_Human0.66643925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.37129492
2MP0003186_abnormal_redox_activity4.41206898
3MP0006036_abnormal_mitochondrial_physio3.53721609
4MP0005360_urolithiasis3.41093000
5MP0002139_abnormal_hepatobiliary_system2.85001985
6MP0005332_abnormal_amino_acid2.58139718
7MP0002132_abnormal_respiratory_system2.52311103
8MP0004043_abnormal_pH_regulation2.49725327
9MP0005451_abnormal_body_composition2.47839573
10MP0006292_abnormal_olfactory_placode2.47625500
11MP0008058_abnormal_DNA_repair2.46691659
12MP0005636_abnormal_mineral_homeostasis2.40333076
13MP0009379_abnormal_foot_pigmentation2.39107290
14MP0004147_increased_porphyrin_level2.37703935
15MP0003878_abnormal_ear_physiology2.30176283
16MP0005377_hearing/vestibular/ear_phenot2.30176283
17MP0005408_hypopigmentation2.28386363
18MP0005085_abnormal_gallbladder_physiolo2.24353333
19MP0000749_muscle_degeneration2.10114184
20MP0003880_abnormal_central_pattern2.09053772
21MP0009643_abnormal_urine_homeostasis2.08920592
22MP0003195_calcinosis2.08199256
23MP0003656_abnormal_erythrocyte_physiolo1.98005837
24MP0003786_premature_aging1.97232261
25MP0001756_abnormal_urination1.95994933
26MP0002938_white_spotting1.92666407
27MP0001764_abnormal_homeostasis1.88619612
28MP0003136_yellow_coat_color1.88339293
29MP0008875_abnormal_xenobiotic_pharmacok1.83752489
30MP0006035_abnormal_mitochondrial_morpho1.83226915
31MP0005584_abnormal_enzyme/coenzyme_acti1.81959024
32MP0003011_delayed_dark_adaptation1.80043639
33MP0002876_abnormal_thyroid_physiology1.78692200
34MP0001542_abnormal_bone_strength1.77592966
35MP0002277_abnormal_respiratory_mucosa1.76852198
36MP0003693_abnormal_embryo_hatching1.69735506
37MP0004782_abnormal_surfactant_physiolog1.69598592
38MP0010094_abnormal_chromosome_stability1.68454095
39MP0002736_abnormal_nociception_after1.66094250
40MP0004019_abnormal_vitamin_homeostasis1.64556093
41MP0009046_muscle_twitch1.58969033
42MP0001984_abnormal_olfaction1.58819578
43MP0005083_abnormal_biliary_tract1.56302190
44MP0006072_abnormal_retinal_apoptosis1.56092062
45MP0008775_abnormal_heart_ventricle1.54004153
46MP0003111_abnormal_nucleus_morphology1.53560268
47MP0008877_abnormal_DNA_methylation1.53481105
48MP0002822_catalepsy1.50482911
49MP0003941_abnormal_skin_development1.50132014
50MP0002148_abnormal_hypersensitivity_rea1.49749531
51MP0008995_early_reproductive_senescence1.44446729
52MP0005084_abnormal_gallbladder_morpholo1.42520587
53MP0003077_abnormal_cell_cycle1.38977336
54MP0002102_abnormal_ear_morphology1.37882967
55MP0005319_abnormal_enzyme/_coenzyme1.37220332
56MP0009745_abnormal_behavioral_response1.35022189
57MP0002638_abnormal_pupillary_reflex1.34712857
58MP0005551_abnormal_eye_electrophysiolog1.34087737
59MP0000343_altered_response_to1.32416945
60MP0001529_abnormal_vocalization1.31794509
61MP0005330_cardiomyopathy1.30946389
62MP0005266_abnormal_metabolism1.30380038
63MP0005379_endocrine/exocrine_gland_phen1.29761997
64MP0001663_abnormal_digestive_system1.29570188
65MP0002734_abnormal_mechanical_nocicepti1.28514921
66MP0002272_abnormal_nervous_system1.26577438
67MP0001485_abnormal_pinna_reflex1.25188507
68MP0005365_abnormal_bile_salt1.25022947
69MP0009785_altered_susceptibility_to1.23849345
70MP0000372_irregular_coat_pigmentation1.23077240
71MP0008007_abnormal_cellular_replicative1.22550250
72MP0005646_abnormal_pituitary_gland1.22158866
73MP0002972_abnormal_cardiac_muscle1.21558824
74MP0005376_homeostasis/metabolism_phenot1.19649115
75MP0003646_muscle_fatigue1.17635671
76MP0000490_abnormal_crypts_of1.16230551
77MP0008872_abnormal_physiological_respon1.15906154
78MP0002090_abnormal_vision1.15759155
79MP0006276_abnormal_autonomic_nervous1.14139467
80MP0001293_anophthalmia1.13998614
81MP0003718_maternal_effect1.13287221
82MP0003436_decreased_susceptibility_to1.09741387
83MP0005670_abnormal_white_adipose1.09620257
84MP0002837_dystrophic_cardiac_calcinosis1.09598002
85MP0002138_abnormal_hepatobiliary_system1.09338674
86MP0002064_seizures1.09058009
87MP0005423_abnormal_somatic_nervous1.07984847
88MP0001188_hyperpigmentation1.07371901
89MP0005535_abnormal_body_temperature1.07267963
90MP0003123_paternal_imprinting1.05258208
91MP0001905_abnormal_dopamine_level1.04991502
92MP0000230_abnormal_systemic_arterial1.04222125
93MP0004084_abnormal_cardiac_muscle1.03810073
94MP0004133_heterotaxia1.03441440
95MP0003121_genomic_imprinting1.02626506
96MP0000631_abnormal_neuroendocrine_gland0.99811590
97MP0009697_abnormal_copulation0.99705696
98MP0009840_abnormal_foam_cell0.99694175
99MP0002136_abnormal_kidney_physiology0.98664606
100MP0004270_analgesia0.98446269
101MP0000858_altered_metastatic_potential0.97727656
102MP0000358_abnormal_cell_content/0.97720556
103MP0001666_abnormal_nutrient_absorption0.97644120
104MP0003787_abnormal_imprinting0.97006990
105MP0003938_abnormal_ear_development0.95892124
106MP0002909_abnormal_adrenal_gland0.95784167
107MP0005075_abnormal_melanosome_morpholog0.95598265
108MP0005381_digestive/alimentary_phenotyp0.95488850
109MP0000647_abnormal_sebaceous_gland0.94953321
110MP0009764_decreased_sensitivity_to0.94822989
111MP0006054_spinal_hemorrhage0.94260263
112MP0002210_abnormal_sex_determination0.94217358
113MP0004957_abnormal_blastocyst_morpholog0.94119450
114MP0008469_abnormal_protein_level0.93448087
115MP0005253_abnormal_eye_physiology0.92947943
116MP0003191_abnormal_cellular_cholesterol0.92839530
117MP0002295_abnormal_pulmonary_circulatio0.91695959
118MP0001970_abnormal_pain_threshold0.90538080
119MP0001346_abnormal_lacrimal_gland0.90399524
120MP0003315_abnormal_perineum_morphology0.88946101
121MP0005645_abnormal_hypothalamus_physiol0.88134955
122MP0005166_decreased_susceptibility_to0.87016266
123MP0002095_abnormal_skin_pigmentation0.87001605
124MP0004272_abnormal_basement_membrane0.86653035
125MP0005385_cardiovascular_system_phenoty0.85663486
126MP0001544_abnormal_cardiovascular_syste0.85663486
127MP0003724_increased_susceptibility_to0.85647864
128MP0002118_abnormal_lipid_homeostasis0.85235913
129MP0002557_abnormal_social/conspecific_i0.84250693
130MP0002653_abnormal_ependyma_morphology0.84126153
131MP0001919_abnormal_reproductive_system0.83447952
132MP0008932_abnormal_embryonic_tissue0.82912793
133MP0005389_reproductive_system_phenotype0.82259526
134MP0002572_abnormal_emotion/affect_behav0.81928818
135MP0010386_abnormal_urinary_bladder0.80384485
136MP0010329_abnormal_lipoprotein_level0.79529845
137MP0005499_abnormal_olfactory_system0.78540733
138MP0005394_taste/olfaction_phenotype0.78540733
139MP0001486_abnormal_startle_reflex0.77858188
140MP0001929_abnormal_gametogenesis0.77713701
141MP0003221_abnormal_cardiomyocyte_apopto0.77351197
142MP0002735_abnormal_chemical_nociception0.77262528
143MP0003122_maternal_imprinting0.76514906
144MP0002163_abnormal_gland_morphology0.75929580
145MP0009333_abnormal_splenocyte_physiolog0.74421620
146MP0004142_abnormal_muscle_tone0.73814451
147MP0005164_abnormal_response_to0.73382079
148MP0009642_abnormal_blood_homeostasis0.72645412
149MP0006082_CNS_inflammation0.72496466
150MP0001765_abnormal_ion_homeostasis0.72062466
151MP0004883_abnormal_blood_vessel0.71154450
152MP0008789_abnormal_olfactory_epithelium0.70981869
153MP0010030_abnormal_orbit_morphology0.69253296
154MP0003879_abnormal_hair_cell0.69021162
155MP0001968_abnormal_touch/_nociception0.68932094
156MP0010155_abnormal_intestine_physiology0.68805890
157MP0002160_abnormal_reproductive_system0.68025761

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.82265046
2Abnormal mitochondria in muscle tissue (HP:0008316)6.36926255
3Acute encephalopathy (HP:0006846)6.10153363
4Progressive macrocephaly (HP:0004481)5.57037444
5Mitochondrial inheritance (HP:0001427)5.56883770
6Increased CSF lactate (HP:0002490)4.90593506
7Hepatic necrosis (HP:0002605)4.89937094
8Hepatocellular necrosis (HP:0001404)4.65099720
9Cerebral edema (HP:0002181)4.49175251
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.30014786
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.30014786
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.93746825
13Respiratory failure (HP:0002878)3.70575032
14Exercise intolerance (HP:0003546)3.64698292
15Lactic acidosis (HP:0003128)3.57169412
16Lipid accumulation in hepatocytes (HP:0006561)3.46771459
17Increased hepatocellular lipid droplets (HP:0006565)3.45336460
18Generalized aminoaciduria (HP:0002909)3.44487239
19Increased muscle lipid content (HP:0009058)3.39407920
20Increased intramyocellular lipid droplets (HP:0012240)3.36619750
21Glycosuria (HP:0003076)3.33901873
22Abnormality of urine glucose concentration (HP:0011016)3.33901873
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.30091398
24Abnormality of cells of the erythroid lineage (HP:0012130)3.23070572
25Increased serum lactate (HP:0002151)3.21188227
26Abnormal number of erythroid precursors (HP:0012131)3.20640824
27Leukodystrophy (HP:0002415)3.10674558
28Nausea (HP:0002018)3.06979484
29Lethargy (HP:0001254)3.04551886
30Conjunctival hamartoma (HP:0100780)3.00889336
31Proximal tubulopathy (HP:0000114)2.98009613
32Renal Fanconi syndrome (HP:0001994)2.94580133
33Neuroendocrine neoplasm (HP:0100634)2.92469466
34Pheochromocytoma (HP:0002666)2.91677475
35Optic disc pallor (HP:0000543)2.84932684
36Dicarboxylic aciduria (HP:0003215)2.81773379
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.81773379
38Hyperphosphaturia (HP:0003109)2.81046285
39Increased serum pyruvate (HP:0003542)2.78551973
40Abnormality of glycolysis (HP:0004366)2.78551973
41Neoplasm of the adrenal gland (HP:0100631)2.77752742
423-Methylglutaconic aciduria (HP:0003535)2.72631715
43Exertional dyspnea (HP:0002875)2.71698821
44Abnormality of fatty-acid metabolism (HP:0004359)2.64393309
45Vomiting (HP:0002013)2.60853677
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.59047202
47Abnormal tarsal ossification (HP:0008369)2.52791338
48Ileus (HP:0002595)2.51707778
49Type I transferrin isoform profile (HP:0003642)2.44041615
50Cerebral hypomyelination (HP:0006808)2.39481164
51Methylmalonic acidemia (HP:0002912)2.38742413
52Myokymia (HP:0002411)2.36764336
53Renal tubular dysfunction (HP:0000124)2.32931555
54Palpitations (HP:0001962)2.32389030
55Abnormality of renal resorption (HP:0011038)2.31496278
56Abnormality of the anterior horn cell (HP:0006802)2.30486435
57Degeneration of anterior horn cells (HP:0002398)2.30486435
58Irregular epiphyses (HP:0010582)2.29584163
59Hypoglycemic coma (HP:0001325)2.28211058
60Diaphragmatic weakness (HP:0009113)2.26191247
61Abnormality of magnesium homeostasis (HP:0004921)2.24077724
62CNS demyelination (HP:0007305)2.23991112
63Aplastic anemia (HP:0001915)2.23224353
64Abnormal urine phosphate concentration (HP:0012599)2.22313390
65Hyperactive renin-angiotensin system (HP:0000841)2.21737002
66Hyperglycinemia (HP:0002154)2.19361008
67Pustule (HP:0200039)2.18994337
68Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18858827
69Respiratory difficulties (HP:0002880)2.18722593
70Hyperglycinuria (HP:0003108)2.13652741
71Reticulocytopenia (HP:0001896)2.13291425
72Sparse eyelashes (HP:0000653)2.13198379
73Oral leukoplakia (HP:0002745)2.12474228
74Metabolic alkalosis (HP:0200114)2.11222496
75Congenital, generalized hypertrichosis (HP:0004540)2.05487902
76Abnormality of the labia minora (HP:0012880)2.04646459
77Abnormality of alanine metabolism (HP:0010916)2.02564526
78Hyperalaninemia (HP:0003348)2.02564526
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02564526
80Abnormality of methionine metabolism (HP:0010901)2.00499225
81Abnormality of serum amino acid levels (HP:0003112)1.99981871
82Delayed epiphyseal ossification (HP:0002663)1.99674294
83Alkalosis (HP:0001948)1.99158402
84Metabolic acidosis (HP:0001942)1.98176037
85Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97318247
86Abnormal gallbladder physiology (HP:0012438)1.95696560
87Cholecystitis (HP:0001082)1.95696560
88Abnormal protein glycosylation (HP:0012346)1.95432677
89Abnormal glycosylation (HP:0012345)1.95432677
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95432677
91Abnormal protein N-linked glycosylation (HP:0012347)1.95432677
92Microvesicular hepatic steatosis (HP:0001414)1.94380976
93Methylmalonic aciduria (HP:0012120)1.94049779
94Emotional lability (HP:0000712)1.93161159
95Patent foramen ovale (HP:0001655)1.92177104
96Colon cancer (HP:0003003)1.92069985
97Pancytopenia (HP:0001876)1.90249113
98Hyperammonemia (HP:0001987)1.89068710
99X-linked dominant inheritance (HP:0001423)1.89049248
100Multiple enchondromatosis (HP:0005701)1.86753493
101Megaloblastic anemia (HP:0001889)1.86459987
102Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85900929
103Testicular atrophy (HP:0000029)1.82891737
104Macrocytic anemia (HP:0001972)1.82578856
105Pancreatic fibrosis (HP:0100732)1.82513658
106Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82326654
107Poor suck (HP:0002033)1.81126698
108Renal salt wasting (HP:0000127)1.80649580
109Renal tubular acidosis (HP:0001947)1.76941290
110Pallor (HP:0000980)1.74606215
111Rhabdomyolysis (HP:0003201)1.74561299
112Petechiae (HP:0000967)1.73450192
113CNS hypomyelination (HP:0003429)1.73166683
114Hypokalemic alkalosis (HP:0001949)1.73122887
115Hyperbilirubinemia (HP:0002904)1.72826867
116Pancreatic cysts (HP:0001737)1.72301027
117Congenital ichthyosiform erythroderma (HP:0007431)1.72031972
118Carpal bone hypoplasia (HP:0001498)1.71745478
119Abnormality of chloride homeostasis (HP:0011422)1.71263447
120Redundant skin (HP:0001582)1.71094481
121Abnormality of carpal bone ossification (HP:0006257)1.70760028
122Aplasia/hypoplasia of the uterus (HP:0008684)1.70524236
123Septo-optic dysplasia (HP:0100842)1.70379641
124Bone cyst (HP:0012062)1.69436875
125Hydroxyprolinuria (HP:0003080)1.69057505
126Abnormality of proline metabolism (HP:0010907)1.69057505
127Sclerocornea (HP:0000647)1.68863569
128Poor head control (HP:0002421)1.68036157
129Abnormality of midbrain morphology (HP:0002418)1.68004114
130Molar tooth sign on MRI (HP:0002419)1.68004114
131Delayed CNS myelination (HP:0002188)1.66617053
132Neoplasm of head and neck (HP:0012288)1.65904607
133Esophageal neoplasm (HP:0100751)1.65904607
134Hyperaldosteronism (HP:0000859)1.65866463
135Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64609107
136Hypokinesia (HP:0002375)1.63578658
137Abnormality of vitamin B metabolism (HP:0004340)1.63495486
138Blindness (HP:0000618)1.63226351
139Abnormality of the vocal cords (HP:0008777)1.62599914
140Amniotic constriction ring (HP:0009775)1.62534059
141Abnormality of placental membranes (HP:0011409)1.62534059
142Gliosis (HP:0002171)1.61064041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.81224616
2CDK194.55402335
3NME23.57972125
4ARAF3.38089682
5PIM23.32814278
6TESK13.29575203
7MYLK3.10415726
8BCKDK2.86177193
9PDK22.71303313
10LIMK12.66934800
11NME12.33660812
12OBSCN2.29809459
13ZAK2.24296807
14CDC72.14030475
15STK162.11449944
16STK38L2.00700427
17PIK3CA1.92135911
18ABL21.90676620
19TESK21.85801300
20MAP3K121.81684776
21EIF2AK11.75667619
22BRAF1.74038085
23STK241.73843854
24MAP3K111.69192563
25WNK41.65610899
26PBK1.62906057
27PLK41.62146993
28NEK11.62101465
29NUAK11.55324141
30VRK11.54092824
31DAPK31.53907559
32TLK11.51902416
33TRIM281.46317719
34BUB11.46112097
35KDR1.35474092
36SIK31.33293441
37GRK51.31022053
38MST41.28544857
39LMTK21.27836675
40PRKG21.23609102
41MAP4K21.22572161
42ILK1.21820999
43CSNK1G31.18213028
44MAP3K141.15423447
45BMPR21.13399434
46MST1R1.12768990
47BRSK11.06695764
48EPHA41.06398013
49CSNK1G11.05700530
50EPHB21.01645517
51CSNK1G21.01061722
52BCR0.98237300
53GRK10.97840660
54MAP2K70.97562232
55TAF10.97194422
56IRAK30.97060681
57BRSK20.94631016
58WNK30.90489330
59TNIK0.83480485
60EPHA20.83055176
61CASK0.82109569
62CSNK1A1L0.81204873
63MAP3K100.80613277
64PRKCG0.79848110
65MAP2K20.76454894
66TSSK60.76269818
67PAK10.75016202
68CDK11A0.72118849
69MAP2K60.71799328
70MAP3K30.71208699
71CSNK2A20.70188155
72OXSR10.69923813
73CHEK20.66914625
74STK40.66759591
75MINK10.65700751
76ATR0.65114955
77MARK30.64235971
78AURKA0.63418969
79PRKCI0.62113423
80MAP2K30.57782092
81CCNB10.56570543
82MAP2K10.56106175
83CDK180.56028792
84CAMK2G0.55602849
85CDK140.55334603
86PHKG10.55130481
87PHKG20.55130481
88RPS6KA50.55006389
89CDK80.54892029
90INSRR0.53900380
91PINK10.53369608
92EIF2AK30.52959914
93RIPK40.51736753
94PIM10.51025490
95ERN10.50772842
96PAK30.50176375
97LRRK20.50104545
98NEK90.49792704
99MUSK0.49776167
100STK390.49523860
101TBK10.49466921
102PLK20.49352448
103CSNK1A10.49085298
104IRAK40.47952462
105CDK150.46943799
106CSNK1E0.46728822
107ADRBK20.46481364
108PRKCD0.46440120
109CSNK2A10.45970146
110DYRK20.43866734
111PLK30.43079616
112MAPKAPK50.42450965
113CAMK2D0.42033523
114DAPK10.40509687
115MAPKAPK30.40261383
116WEE10.36758172
117AURKB0.36381116
118MKNK20.35760719
119MAP3K80.35731002
120PRKCE0.35575248
121MAP3K40.35171166
122CAMK2A0.34452331
123PLK10.33160275
124ERBB30.32899315
125MAPK130.32297285
126CDC42BPA0.29601724
127RAF10.29141399
128IKBKB0.28810183
129TAOK10.28602736
130TAOK20.27347101
131BMPR1B0.26673366
132EIF2AK20.25277168
133ROCK10.25211793
134ADRBK10.25173671
135SRPK10.24505604
136PAK40.23680345
137TRPM70.22764582
138PRKCA0.22320351
139TTK0.22020370
140KSR20.21700880

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.45866977
2Parkinsons disease_Homo sapiens_hsa050124.88765405
3Huntingtons disease_Homo sapiens_hsa050163.44160409
4Alzheimers disease_Homo sapiens_hsa050103.34512775
5Ribosome_Homo sapiens_hsa030103.18606722
6Proteasome_Homo sapiens_hsa030503.16595844
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.16282694
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90887580
9Sulfur metabolism_Homo sapiens_hsa009202.81982604
10* Cardiac muscle contraction_Homo sapiens_hsa042602.34005230
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09654887
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92009953
13Protein export_Homo sapiens_hsa030601.87408426
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76192804
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67569814
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64389713
17RNA polymerase_Homo sapiens_hsa030201.62747150
18Sulfur relay system_Homo sapiens_hsa041221.53713160
19Glutathione metabolism_Homo sapiens_hsa004801.53110589
20Carbon metabolism_Homo sapiens_hsa012001.53031889
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51811594
22Folate biosynthesis_Homo sapiens_hsa007901.50371871
23Pyruvate metabolism_Homo sapiens_hsa006201.48768406
24Pyrimidine metabolism_Homo sapiens_hsa002401.45239376
25Propanoate metabolism_Homo sapiens_hsa006401.43422116
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31904698
27DNA replication_Homo sapiens_hsa030301.29273062
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29134783
29Phenylalanine metabolism_Homo sapiens_hsa003601.27600777
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25805771
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16239507
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14930042
33Butanoate metabolism_Homo sapiens_hsa006501.14387588
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11702600
35Peroxisome_Homo sapiens_hsa041461.10970633
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10113022
37Vitamin B6 metabolism_Homo sapiens_hsa007501.07933087
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06208330
39Fatty acid degradation_Homo sapiens_hsa000711.05973681
40beta-Alanine metabolism_Homo sapiens_hsa004101.05444086
41Collecting duct acid secretion_Homo sapiens_hsa049661.05126004
42RNA transport_Homo sapiens_hsa030131.04615188
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.04527502
44Fanconi anemia pathway_Homo sapiens_hsa034601.03237850
45Basal transcription factors_Homo sapiens_hsa030221.02675966
46RNA degradation_Homo sapiens_hsa030181.00914329
47Fructose and mannose metabolism_Homo sapiens_hsa000510.98970062
48* Metabolic pathways_Homo sapiens_hsa011000.97285634
49Biosynthesis of amino acids_Homo sapiens_hsa012300.94192442
50Mismatch repair_Homo sapiens_hsa034300.93631380
51Galactose metabolism_Homo sapiens_hsa000520.93015818
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92948111
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92832472
54Tryptophan metabolism_Homo sapiens_hsa003800.91390471
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89056594
56Histidine metabolism_Homo sapiens_hsa003400.88761708
57Tyrosine metabolism_Homo sapiens_hsa003500.88235889
58Arachidonic acid metabolism_Homo sapiens_hsa005900.87448320
59Mineral absorption_Homo sapiens_hsa049780.87276687
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85992765
61Fatty acid elongation_Homo sapiens_hsa000620.83309162
62Non-homologous end-joining_Homo sapiens_hsa034500.82195499
63Pentose phosphate pathway_Homo sapiens_hsa000300.81667872
64Caffeine metabolism_Homo sapiens_hsa002320.78196156
65Chemical carcinogenesis_Homo sapiens_hsa052040.78026315
66Vibrio cholerae infection_Homo sapiens_hsa051100.76459743
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.71660210
68Arginine and proline metabolism_Homo sapiens_hsa003300.68410736
69Selenocompound metabolism_Homo sapiens_hsa004500.64119982
70Base excision repair_Homo sapiens_hsa034100.61773519
71Fatty acid metabolism_Homo sapiens_hsa012120.61177754
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.61119670
73Renin-angiotensin system_Homo sapiens_hsa046140.60800269
74Homologous recombination_Homo sapiens_hsa034400.60662444
75Purine metabolism_Homo sapiens_hsa002300.59771829
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.59003936
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57090269
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57033438
79PPAR signaling pathway_Homo sapiens_hsa033200.56759690
80Nitrogen metabolism_Homo sapiens_hsa009100.56139487
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55416217
82Phototransduction_Homo sapiens_hsa047440.54701200
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.52314248
84Nucleotide excision repair_Homo sapiens_hsa034200.48656677
85Nicotine addiction_Homo sapiens_hsa050330.48107620
86Fat digestion and absorption_Homo sapiens_hsa049750.47916266
87N-Glycan biosynthesis_Homo sapiens_hsa005100.47478923
88Starch and sucrose metabolism_Homo sapiens_hsa005000.46684881
89Cell cycle_Homo sapiens_hsa041100.41931701
90Arginine biosynthesis_Homo sapiens_hsa002200.40698327
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40175933
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39089720
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37810869
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37598188
95Rheumatoid arthritis_Homo sapiens_hsa053230.36701836
96One carbon pool by folate_Homo sapiens_hsa006700.34600288
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34516565
98Phagosome_Homo sapiens_hsa041450.34498256
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33054805
100Synaptic vesicle cycle_Homo sapiens_hsa047210.33035692
101Oocyte meiosis_Homo sapiens_hsa041140.30492242
102African trypanosomiasis_Homo sapiens_hsa051430.29585826
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29277361
104Legionellosis_Homo sapiens_hsa051340.29018787
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27198839
106Regulation of autophagy_Homo sapiens_hsa041400.25952590
107Vitamin digestion and absorption_Homo sapiens_hsa049770.23934321
108Linoleic acid metabolism_Homo sapiens_hsa005910.23183003
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20156660
110Asthma_Homo sapiens_hsa053100.18532106
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17715152
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17282052
113Steroid biosynthesis_Homo sapiens_hsa001000.16822264
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.16284485
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15715278
116Bile secretion_Homo sapiens_hsa049760.15462029
117Graft-versus-host disease_Homo sapiens_hsa053320.14649709
118Retinol metabolism_Homo sapiens_hsa008300.13776744
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12874695
120Spliceosome_Homo sapiens_hsa030400.12815898

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