COX5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.52740232
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.52740232
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.68561323
4* respiratory electron transport chain (GO:0022904)8.44503696
5* electron transport chain (GO:0022900)8.21400660
6oxidative phosphorylation (GO:0006119)7.08843101
7tricarboxylic acid cycle (GO:0006099)5.92490053
8ATP biosynthetic process (GO:0006754)5.69237967
9viral transcription (GO:0019083)5.22365179
10translational termination (GO:0006415)5.01419123
11purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.99033811
12purine nucleoside triphosphate biosynthetic process (GO:0009145)4.92662494
13inner mitochondrial membrane organization (GO:0007007)4.75714847
14ribosomal small subunit assembly (GO:0000028)4.72007797
15protein complex biogenesis (GO:0070271)4.69213275
16sarcomere organization (GO:0045214)4.65127410
17ribosomal small subunit biogenesis (GO:0042274)4.60110691
18* hydrogen ion transmembrane transport (GO:1902600)4.53653734
19ribonucleoside triphosphate biosynthetic process (GO:0009201)4.51216746
20mitochondrial respiratory chain complex assembly (GO:0033108)4.50628617
21translational elongation (GO:0006414)4.48046625
22NADH metabolic process (GO:0006734)4.47769635
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.46859258
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.46859258
25NADH dehydrogenase complex assembly (GO:0010257)4.46859258
26regulation of mitochondrial translation (GO:0070129)4.36755320
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30925475
28protein targeting to ER (GO:0045047)4.28595844
29proteasome assembly (GO:0043248)4.27237125
30protein neddylation (GO:0045116)4.24502565
31cotranslational protein targeting to membrane (GO:0006613)4.23475460
32quinone biosynthetic process (GO:1901663)4.17752970
33ubiquinone biosynthetic process (GO:0006744)4.17752970
34establishment of protein localization to endoplasmic reticulum (GO:0072599)4.12207512
35aerobic respiration (GO:0009060)4.08548508
36termination of RNA polymerase III transcription (GO:0006386)4.07737344
37transcription elongation from RNA polymerase III promoter (GO:0006385)4.07737344
38protein localization to endoplasmic reticulum (GO:0070972)4.04773089
39positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.97483116
40cellular protein complex disassembly (GO:0043624)3.94643706
41nucleoside triphosphate biosynthetic process (GO:0009142)3.91755727
42viral life cycle (GO:0019058)3.91471856
43purine nucleoside monophosphate biosynthetic process (GO:0009127)3.90662077
44purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.90662077
45DNA deamination (GO:0045006)3.90283137
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.89432073
47protein targeting to membrane (GO:0006612)3.80754415
48* proton transport (GO:0015992)3.79359948
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.76835734
50succinate metabolic process (GO:0006105)3.75953117
51mitochondrial transport (GO:0006839)3.74917353
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.73756267
53* hydrogen transport (GO:0006818)3.73147391
54muscle filament sliding (GO:0030049)3.71489167
55actin-myosin filament sliding (GO:0033275)3.71489167
56cardiac myofibril assembly (GO:0055003)3.70586401
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.68844548
58cellular component biogenesis (GO:0044085)3.65920306
59cardiac muscle contraction (GO:0060048)3.65173063
60heart process (GO:0003015)3.60858117
61heart contraction (GO:0060047)3.60858117
62pseudouridine synthesis (GO:0001522)3.59409155
63regulation of oxidative phosphorylation (GO:0002082)3.59116142
64regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.59021520
65regulation of cofactor metabolic process (GO:0051193)3.58572521
66regulation of coenzyme metabolic process (GO:0051196)3.58572521
67translational initiation (GO:0006413)3.57917644
68ubiquinone metabolic process (GO:0006743)3.56552068
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50738253
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49548668
71cellular ketone body metabolic process (GO:0046950)3.48301536
72respiratory chain complex IV assembly (GO:0008535)3.47352699
73regulation of cellular respiration (GO:0043457)3.44425801
74heme biosynthetic process (GO:0006783)3.44090133
75chaperone-mediated protein transport (GO:0072321)3.43787963
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42926824
77lysine catabolic process (GO:0006554)3.40948974
78lysine metabolic process (GO:0006553)3.40948974
79ribosomal large subunit biogenesis (GO:0042273)3.39944458
80protein-cofactor linkage (GO:0018065)3.39649580
81translation (GO:0006412)3.39408288
82regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.38763185
83regulation of relaxation of muscle (GO:1901077)3.37775697
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35582019
85negative regulation of potassium ion transmembrane transport (GO:1901380)3.34711444
86* generation of precursor metabolites and energy (GO:0006091)3.33828243
87myofibril assembly (GO:0030239)3.32736967
88regulation of cell communication by electrical coupling (GO:0010649)3.31927156
89regulation of cellular amino acid metabolic process (GO:0006521)3.30548409
90nuclear-transcribed mRNA catabolic process (GO:0000956)3.29403490
91rRNA modification (GO:0000154)3.27956057
92cytochrome complex assembly (GO:0017004)3.27563588
93protein targeting to mitochondrion (GO:0006626)3.27553085
94protein complex disassembly (GO:0043241)3.26887692
95ribonucleoside monophosphate biosynthetic process (GO:0009156)3.24281260
96cellular respiration (GO:0045333)3.24126687
97GTP biosynthetic process (GO:0006183)3.23722886
98maturation of SSU-rRNA (GO:0030490)3.23549938
99carnitine shuttle (GO:0006853)3.22049048
100intracellular protein transmembrane import (GO:0044743)3.21838991
101ribonucleoprotein complex biogenesis (GO:0022613)3.21617360
102establishment of protein localization to mitochondrion (GO:0072655)3.21454507
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20835084
104negative regulation of ligase activity (GO:0051352)3.20835084
105purine nucleoside biosynthetic process (GO:0042451)3.20156855
106purine ribonucleoside biosynthetic process (GO:0046129)3.20156855
107regulation of actin filament-based movement (GO:1903115)3.16766504
108protein localization to mitochondrion (GO:0070585)3.15972806
109ketone body metabolic process (GO:1902224)3.15862826
110macromolecular complex disassembly (GO:0032984)3.15185207
111metallo-sulfur cluster assembly (GO:0031163)3.13989855
112iron-sulfur cluster assembly (GO:0016226)3.13989855
113aspartate family amino acid catabolic process (GO:0009068)3.13644346
114nucleoside monophosphate biosynthetic process (GO:0009124)3.13638899
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.13363475
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13229324
117cytidine metabolic process (GO:0046087)3.12850556
118cytidine catabolic process (GO:0006216)3.12850556
119cytidine deamination (GO:0009972)3.12850556
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11968215
121RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11968215
122mRNA catabolic process (GO:0006402)3.11619431
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03032583
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02561798
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99993736
126cullin deneddylation (GO:0010388)2.94825144
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94313455
128spliceosomal snRNP assembly (GO:0000387)2.94309560
129rRNA processing (GO:0006364)2.93185857
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89603553
131signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89603553
132signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89603553
133intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88560183
134signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88560183
135protein targeting (GO:0006605)2.86640840
136RNA catabolic process (GO:0006401)2.85352109
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85020384
138base-excision repair, AP site formation (GO:0006285)2.82716806
139rRNA metabolic process (GO:0016072)2.79735900
140mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.3345529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.16302905
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.71222503
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.77225731
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67661868
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.66751651
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41100247
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31513488
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.18019742
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.04790465
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.00148216
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99616457
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96536323
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79525345
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64219017
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57392500
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55040277
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36257621
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28349768
19* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.25324942
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19921936
21XRN2_22483619_ChIP-Seq_HELA_Human2.19366466
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17150268
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.14069510
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12860492
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10998668
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.10911621
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10392841
28SRY_22984422_ChIP-ChIP_TESTIS_Rat2.04933235
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02368692
30DCP1A_22483619_ChIP-Seq_HELA_Human2.01154638
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98498792
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77257995
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73884678
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73361813
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72520501
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72338792
37* VDR_23849224_ChIP-Seq_CD4+_Human1.71063633
38ZNF263_19887448_ChIP-Seq_K562_Human1.68044080
39ELK1_19687146_ChIP-ChIP_HELA_Human1.66253651
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65862647
41BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.60753304
42CTCF_18555785_ChIP-Seq_MESCs_Mouse1.60361918
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.60076089
44* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58551327
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57161576
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.57077728
47TTF2_22483619_ChIP-Seq_HELA_Human1.53967481
48* GABP_19822575_ChIP-Seq_HepG2_Human1.50474461
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49065549
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48424681
51FOXP3_21729870_ChIP-Seq_TREG_Human1.46937516
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46412047
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44902864
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40435025
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38266171
56* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35981719
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32837423
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31981277
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.31001193
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.24381825
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19708056
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18642218
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17309080
64* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17031061
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16179548
66EZH2_22144423_ChIP-Seq_EOC_Human1.15795626
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13220495
68* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13182653
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.12889781
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.11975090
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11705409
72E2F7_22180533_ChIP-Seq_HELA_Human1.10910085
73* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10784868
74* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10361673
75BCL6_27268052_Chip-Seq_Bcells_Human1.08905976
76* RXR_22158963_ChIP-Seq_LIVER_Mouse1.08275577
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06994547
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04988370
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04767344
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04743543
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04410049
82* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03162617
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02668848
84VDR_22108803_ChIP-Seq_LS180_Human1.02084292
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.01457665
86SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00716077
87TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00628829
88MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00139791
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99651299
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99417793
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98753724
92* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98013493
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97369640
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97018637
95* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96233747
96MYC_18940864_ChIP-ChIP_HL60_Human0.95737474
97VDR_21846776_ChIP-Seq_THP-1_Human0.95651212
98GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92925112
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92862498
100SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92469055
101CIITA_25753668_ChIP-Seq_RAJI_Human0.92361946
102RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92330532
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92180556
104E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92004295
105BCOR_27268052_Chip-Seq_Bcells_Human0.91517301
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90617810
107SA1_27219007_Chip-Seq_Bcells_Human0.90492846
108P68_20966046_ChIP-Seq_HELA_Human0.88683217
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88542628
110CTCF_20526341_ChIP-Seq_ESCs_Human0.88168148
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88120839
112STAT1_20625510_ChIP-Seq_HELA_Human0.88073167
113LXR_22292898_ChIP-Seq_THP-1_Human0.86730308
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85780811
115NANOG_20526341_ChIP-Seq_ESCs_Human0.85335061
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83676987
117KDM5A_27292631_Chip-Seq_BREAST_Human0.83499864
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83278477
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.81288154
120TP53_22573176_ChIP-Seq_HFKS_Human0.80889876
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.80740333
122TAF2_19829295_ChIP-Seq_ESCs_Human0.78808221
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77120136
124PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76799117
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76305057
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75960401
127E2F1_20622854_ChIP-Seq_HELA_Human0.75874066
128ERG_20517297_ChIP-Seq_VCAP_Human0.73887552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.89124315
2MP0003646_muscle_fatigue5.86520695
3MP0004215_abnormal_myocardial_fiber4.27880692
4MP0004084_abnormal_cardiac_muscle4.18522407
5MP0000751_myopathy4.02720151
6MP0006036_abnormal_mitochondrial_physio3.87851575
7MP0005330_cardiomyopathy3.57162472
8MP0000749_muscle_degeneration3.54376535
9MP0004036_abnormal_muscle_relaxation3.21871288
10MP0003806_abnormal_nucleotide_metabolis2.67711146
11MP0003137_abnormal_impulse_conducting2.59422865
12MP0006035_abnormal_mitochondrial_morpho2.54842619
13MP0002972_abnormal_cardiac_muscle2.48989255
14MP0009379_abnormal_foot_pigmentation2.48002429
15MP0006292_abnormal_olfactory_placode2.38687576
16MP0008775_abnormal_heart_ventricle2.37046609
17MP0000750_abnormal_muscle_regeneration2.35051684
18MP0004043_abnormal_pH_regulation2.34787321
19MP0004087_abnormal_muscle_fiber2.30553865
20MP0004484_altered_response_of2.17272548
21MP0003011_delayed_dark_adaptation2.16133650
22MP0003136_yellow_coat_color2.09840207
23MP0004130_abnormal_muscle_cell2.07450408
24MP0001544_abnormal_cardiovascular_syste2.04705360
25MP0005385_cardiovascular_system_phenoty2.04705360
26MP0005620_abnormal_muscle_contractility2.03061637
27MP0003221_abnormal_cardiomyocyte_apopto1.96802987
28MP0002106_abnormal_muscle_physiology1.91908341
29MP0002269_muscular_atrophy1.86488504
30MP0003186_abnormal_redox_activity1.79843712
31MP0002277_abnormal_respiratory_mucosa1.78918371
32MP0002638_abnormal_pupillary_reflex1.78257398
33MP0000747_muscle_weakness1.67072563
34MP0010630_abnormal_cardiac_muscle1.66676407
35MP0005360_urolithiasis1.66063123
36MP0004145_abnormal_muscle_electrophysio1.63494650
37MP0004147_increased_porphyrin_level1.62020304
38MP0006138_congestive_heart_failure1.61792646
39MP0003718_maternal_effect1.56461764
40MP0000759_abnormal_skeletal_muscle1.55343667
41MP0009046_muscle_twitch1.54956229
42MP0005266_abnormal_metabolism1.52675856
43MP0002822_catalepsy1.48293583
44MP0004085_abnormal_heartbeat1.47013797
45MP0002332_abnormal_exercise_endurance1.46751589
46MP0005332_abnormal_amino_acid1.46552481
47MP0005369_muscle_phenotype1.45649299
48MP0001529_abnormal_vocalization1.41380135
49MP0002272_abnormal_nervous_system1.37801534
50MP0005085_abnormal_gallbladder_physiolo1.36655816
51MP0003195_calcinosis1.36566222
52MP0002938_white_spotting1.34471690
53MP0005646_abnormal_pituitary_gland1.33451568
54MP0003828_pulmonary_edema1.31711078
55MP0006072_abnormal_retinal_apoptosis1.30532740
56MP0005666_abnormal_adipose_tissue1.29287314
57MP0005636_abnormal_mineral_homeostasis1.28939854
58MP0001968_abnormal_touch/_nociception1.28707432
59MP0002653_abnormal_ependyma_morphology1.28461585
60MP0009745_abnormal_behavioral_response1.28014921
61MP0008995_early_reproductive_senescence1.26637777
62MP0005083_abnormal_biliary_tract1.26177190
63MP0008058_abnormal_DNA_repair1.25797921
64MP0003656_abnormal_erythrocyte_physiolo1.24518655
65MP0004019_abnormal_vitamin_homeostasis1.24093216
66MP0005645_abnormal_hypothalamus_physiol1.22279641
67MP0000343_altered_response_to1.20615870
68MP0001984_abnormal_olfaction1.19065429
69MP0004233_abnormal_muscle_weight1.19057171
70MP0009643_abnormal_urine_homeostasis1.18431592
71MP0003786_premature_aging1.15785483
72MP0010030_abnormal_orbit_morphology1.14900674
73MP0002163_abnormal_gland_morphology1.14811062
74MP0005451_abnormal_body_composition1.14618003
75MP0005165_increased_susceptibility_to1.14296639
76MP0002139_abnormal_hepatobiliary_system1.11556827
77MP0005584_abnormal_enzyme/coenzyme_acti1.11321171
78MP0005423_abnormal_somatic_nervous1.11029755
79MP0005319_abnormal_enzyme/_coenzyme1.10556314
80MP0005551_abnormal_eye_electrophysiolog1.09151473
81MP0003567_abnormal_fetal_cardiomyocyte1.07318498
82MP0003123_paternal_imprinting1.05128751
83MP0002064_seizures1.04134271
84MP0002127_abnormal_cardiovascular_syste1.01317342
85MP0004142_abnormal_muscle_tone1.00057406
86MP0005670_abnormal_white_adipose0.99276908
87MP0003938_abnormal_ear_development0.98600933
88MP0000230_abnormal_systemic_arterial0.97447383
89MP0004742_abnormal_vestibular_system0.96563589
90MP0002734_abnormal_mechanical_nocicepti0.94488411
91MP0002876_abnormal_thyroid_physiology0.93699535
92MP0008789_abnormal_olfactory_epithelium0.92647419
93MP0003878_abnormal_ear_physiology0.92107455
94MP0005377_hearing/vestibular/ear_phenot0.92107455
95MP0008875_abnormal_xenobiotic_pharmacok0.91261205
96MP0003283_abnormal_digestive_organ0.90788537
97MP0004957_abnormal_blastocyst_morpholog0.90662772
98MP0002160_abnormal_reproductive_system0.90406654
99MP0002234_abnormal_pharynx_morphology0.87549174
100MP0000631_abnormal_neuroendocrine_gland0.86673225
101MP0001756_abnormal_urination0.85550519
102MP0003879_abnormal_hair_cell0.85494946
103MP0001986_abnormal_taste_sensitivity0.84735435
104MP0010386_abnormal_urinary_bladder0.82084264
105MP0009840_abnormal_foam_cell0.81920904
106MP0000358_abnormal_cell_content/0.81530434
107MP0000049_abnormal_middle_ear0.81464132
108MP0001663_abnormal_digestive_system0.80925711
109MP0001970_abnormal_pain_threshold0.79917321
110MP0005535_abnormal_body_temperature0.79293311
111MP0005253_abnormal_eye_physiology0.78163485
112MP0002909_abnormal_adrenal_gland0.76998025
113MP0002132_abnormal_respiratory_system0.76843056
114MP0001765_abnormal_ion_homeostasis0.76679368
115MP0005408_hypopigmentation0.76514391
116MP0002733_abnormal_thermal_nociception0.75850679
117MP0002102_abnormal_ear_morphology0.75161586
118MP0000026_abnormal_inner_ear0.73696340
119MP0006276_abnormal_autonomic_nervous0.72855799
120MP0005376_homeostasis/metabolism_phenot0.72412802
121MP0002095_abnormal_skin_pigmentation0.71216948
122MP0001486_abnormal_startle_reflex0.71021082
123MP0003693_abnormal_embryo_hatching0.70847476
124MP0004133_heterotaxia0.70428155
125MP0000013_abnormal_adipose_tissue0.70414527
126MP0005379_endocrine/exocrine_gland_phen0.70001139
127MP0000372_irregular_coat_pigmentation0.69820058
128MP0008872_abnormal_physiological_respon0.68895858
129MP0005075_abnormal_melanosome_morpholog0.68309220
130MP0005389_reproductive_system_phenotype0.68006200
131MP0003638_abnormal_response/metabolism_0.67943520
132MP0004510_myositis0.64407679
133MP0001764_abnormal_homeostasis0.64407491
134MP0002971_abnormal_brown_adipose0.63696777
135MP0005375_adipose_tissue_phenotype0.63374958
136MP0004185_abnormal_adipocyte_glucose0.63035983
137MP0005381_digestive/alimentary_phenotyp0.62637778
138MP0002078_abnormal_glucose_homeostasis0.62365046
139MP0002118_abnormal_lipid_homeostasis0.58482354
140MP0005084_abnormal_gallbladder_morpholo0.55323588
141MP0003880_abnormal_central_pattern0.55117122
142MP0000266_abnormal_heart_morphology0.54139534
143MP0005386_behavior/neurological_phenoty0.53962553
144MP0004924_abnormal_behavior0.53962553
145MP0001905_abnormal_dopamine_level0.53669113
146MP0001485_abnormal_pinna_reflex0.53470910
147MP0003315_abnormal_perineum_morphology0.52785284
148MP0008932_abnormal_embryonic_tissue0.50399186
149MP0005365_abnormal_bile_salt0.48994465
150MP0001727_abnormal_embryo_implantation0.47585608
151MP0002736_abnormal_nociception_after0.45873645

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.52767035
2Abnormal mitochondria in muscle tissue (HP:0008316)6.32000970
3Mitochondrial inheritance (HP:0001427)5.98404883
4Acute encephalopathy (HP:0006846)5.83033283
5Hepatocellular necrosis (HP:0001404)5.71219301
6Hepatic necrosis (HP:0002605)5.69970715
7Progressive macrocephaly (HP:0004481)5.41157408
8Increased CSF lactate (HP:0002490)5.36673360
9Increased intramyocellular lipid droplets (HP:0012240)4.78875919
10Increased muscle lipid content (HP:0009058)4.75568878
11Sudden death (HP:0001699)4.69873778
12Lipid accumulation in hepatocytes (HP:0006561)4.67514047
13Increased hepatocellular lipid droplets (HP:0006565)4.62314269
14Cerebral edema (HP:0002181)4.57623379
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.48666261
16Decreased activity of mitochondrial respiratory chain (HP:0008972)4.48666261
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.28632685
18Lactic acidosis (HP:0003128)4.23358940
19Respiratory failure (HP:0002878)4.02983426
20Exercise intolerance (HP:0003546)3.97380470
21Ventricular tachycardia (HP:0004756)3.82903975
22Increased serum lactate (HP:0002151)3.77987062
23Myoglobinuria (HP:0002913)3.65820305
24Palpitations (HP:0001962)3.57617068
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.51785188
26Renal Fanconi syndrome (HP:0001994)3.48068978
27Rhabdomyolysis (HP:0003201)3.40292679
28Abnormality of dicarboxylic acid metabolism (HP:0010995)3.34726405
29Dicarboxylic aciduria (HP:0003215)3.34726405
30Calf muscle hypertrophy (HP:0008981)3.33534539
31Abnormality of cells of the erythroid lineage (HP:0012130)3.31156713
32Abnormal number of erythroid precursors (HP:0012131)3.27039262
33Abnormality of glycolysis (HP:0004366)3.23323698
34Increased serum pyruvate (HP:0003542)3.23323698
35Muscle hypertrophy of the lower extremities (HP:0008968)3.14741353
36Exercise-induced muscle cramps (HP:0003710)3.11787849
37Myokymia (HP:0002411)3.09374195
38Lipoatrophy (HP:0100578)3.08049217
39Optic disc pallor (HP:0000543)3.06280890
40Exertional dyspnea (HP:0002875)3.06151254
41Exercise-induced myalgia (HP:0003738)3.01656049
42Leukodystrophy (HP:0002415)2.95192711
43Atrial fibrillation (HP:0005110)2.94674854
44Lethargy (HP:0001254)2.91716601
45Abnormality of fatty-acid metabolism (HP:0004359)2.88027117
46Supraventricular tachycardia (HP:0004755)2.87636953
47Ventricular fibrillation (HP:0001663)2.81849422
48Primary atrial arrhythmia (HP:0001692)2.80706385
49Glycosuria (HP:0003076)2.80666684
50Abnormality of urine glucose concentration (HP:0011016)2.80666684
51Supraventricular arrhythmia (HP:0005115)2.79950779
52Ragged-red muscle fibers (HP:0003200)2.78548360
53Respiratory difficulties (HP:0002880)2.76724581
54Syncope (HP:0001279)2.76410018
55Muscle fiber splitting (HP:0003555)2.74284195
56Dilated cardiomyopathy (HP:0001644)2.70719466
57Ketoacidosis (HP:0001993)2.69616945
58Generalized aminoaciduria (HP:0002909)2.69269130
59CNS demyelination (HP:0007305)2.68753814
60Conjunctival hamartoma (HP:0100780)2.63961272
61Hypoglycemic coma (HP:0001325)2.62401679
62Prolonged QT interval (HP:0001657)2.60446503
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59523571
64Abnormality of alanine metabolism (HP:0010916)2.59523571
65Hyperalaninemia (HP:0003348)2.59523571
66Abnormality of the calf musculature (HP:0001430)2.58267801
673-Methylglutaconic aciduria (HP:0003535)2.58138463
68Nemaline bodies (HP:0003798)2.51930676
69Muscle fiber inclusion bodies (HP:0100299)2.51303424
70Pallor (HP:0000980)2.50877288
71Hyperphosphaturia (HP:0003109)2.47428955
72Emotional lability (HP:0000712)2.46017493
73Reticulocytopenia (HP:0001896)2.43962618
74Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.42679478
75Right ventricular cardiomyopathy (HP:0011663)2.40715526
76Vomiting (HP:0002013)2.39976768
77Type I transferrin isoform profile (HP:0003642)2.39923012
78Nausea (HP:0002018)2.39546282
79Hyperammonemia (HP:0001987)2.32525147
80Macrocytic anemia (HP:0001972)2.31515782
81Neuroendocrine neoplasm (HP:0100634)2.31027164
82Pheochromocytoma (HP:0002666)2.30570356
83Ventricular arrhythmia (HP:0004308)2.30146736
84Ketosis (HP:0001946)2.29687421
85Muscle stiffness (HP:0003552)2.28051742
86Myotonia (HP:0002486)2.27932506
87Abnormality of renal resorption (HP:0011038)2.26783205
88Aplastic anemia (HP:0001915)2.24004070
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23657300
90Multiple enchondromatosis (HP:0005701)2.22917774
91Neoplasm of head and neck (HP:0012288)2.19115861
92Esophageal neoplasm (HP:0100751)2.19115861
93Bundle branch block (HP:0011710)2.19005479
94Hyperglycinuria (HP:0003108)2.16958421
95Proximal tubulopathy (HP:0000114)2.16753990
96Abnormality of the left ventricular outflow tract (HP:0011103)2.12372161
97Subaortic stenosis (HP:0001682)2.12372161
98Metabolic acidosis (HP:0001942)2.12182169
99EMG: myopathic abnormalities (HP:0003458)2.10479785
100Methylmalonic aciduria (HP:0012120)2.08710748
101Abnormal EKG (HP:0003115)2.07215914
102Progressive muscle weakness (HP:0003323)2.06412181
103Abnormal urine phosphate concentration (HP:0012599)2.03110338
104Congenital, generalized hypertrichosis (HP:0004540)2.02077140
105Gliosis (HP:0002171)2.01358010
106Asymmetric septal hypertrophy (HP:0001670)1.99148313
107Heart block (HP:0012722)1.91906612
108Hyperglycinemia (HP:0002154)1.91147125
109X-linked dominant inheritance (HP:0001423)1.90893414
110Testicular atrophy (HP:0000029)1.90769415
111Oral leukoplakia (HP:0002745)1.89435401
112Blindness (HP:0000618)1.85079737
113Degeneration of anterior horn cells (HP:0002398)1.81362660
114Abnormality of the anterior horn cell (HP:0006802)1.81362660
115Microvesicular hepatic steatosis (HP:0001414)1.74403537
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74166297
117Abnormal protein N-linked glycosylation (HP:0012347)1.74166297
118Abnormal protein glycosylation (HP:0012346)1.74166297
119Abnormal glycosylation (HP:0012345)1.74166297
120Renal tubular dysfunction (HP:0000124)1.71323443
121Pancytopenia (HP:0001876)1.68552963
122Muscle fiber atrophy (HP:0100295)1.67919334
123Cerebral hypomyelination (HP:0006808)1.67362010
124Abnormality of serum amino acid levels (HP:0003112)1.65563690
125Reduced antithrombin III activity (HP:0001976)1.64109395
126Abnormality of magnesium homeostasis (HP:0004921)1.63676752
127Type 2 muscle fiber atrophy (HP:0003554)1.63471297
128Methylmalonic acidemia (HP:0002912)1.62995994
129Myopathic facies (HP:0002058)1.60375279
130Absent thumb (HP:0009777)1.57466731
131Progressive microcephaly (HP:0000253)1.54450364
132Poor suck (HP:0002033)1.53660091
133Abnormality of aromatic amino acid family metabolism (HP:0004338)1.51552758
134Abnormality of midbrain morphology (HP:0002418)1.50269857
135Molar tooth sign on MRI (HP:0002419)1.50269857
136Paralysis (HP:0003470)1.50119780
137Sparse eyelashes (HP:0000653)1.49100046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.01404627
2NME23.99261089
3BCKDK3.94347011
4MYLK3.61568874
5LMTK23.46702881
6TLK13.28217296
7NME13.26206440
8OBSCN3.00207145
9NEK12.78842079
10TTN2.62978521
11PDK32.48615751
12PDK42.48615751
13STK162.37710901
14PHKG12.23439053
15PHKG22.23439053
16WNK42.21350303
17MUSK2.15537992
18MAP3K111.97479337
19PIK3CA1.82754918
20EIF2AK11.76741304
21CDC71.74423665
22ILK1.74151566
23DAPK31.73826394
24BUB11.67485558
25TESK21.66801046
26DYRK21.66763444
27PINK11.55275523
28MAP3K121.53459529
29ARAF1.52346918
30NUAK11.52244744
31KDR1.51630940
32PKN21.47769319
33WEE11.45580338
34MST41.42354672
35MST1R1.36985376
36VRK11.35307897
37PDK21.30399446
38GRK71.24549279
39CAMK2D1.21196521
40PIM21.21005964
41LIMK11.20999943
42MAP2K71.19114459
43MAPKAPK31.18777466
44ABL21.18049410
45CDK191.10466108
46STK391.09279260
47SRPK11.08356888
48MAP4K21.07747818
49GRK11.07591576
50ADRBK21.05991381
51TESK10.98903316
52TAOK30.98339087
53RPS6KA50.97682758
54INSRR0.90992575
55ZAK0.88627410
56DMPK0.87578196
57CSNK1G30.86836316
58BRAF0.85696274
59CAMK2G0.83517573
60BMPR1B0.80390294
61TRIB30.79665446
62STK240.76705599
63CSNK1G20.75979225
64CCNB10.75789025
65EPHB20.74554193
66LRRK20.74435967
67FLT30.73814213
68PRKG20.73691729
69PLK40.71231012
70MAP2K20.69897588
71AURKA0.69573145
72WNK30.68218946
73CSNK1G10.65903981
74PRKCG0.65171079
75SCYL20.63857983
76TIE10.62610832
77STK40.61191033
78PKN10.59825164
79PLK30.59529225
80AURKB0.58940067
81CDK80.54826994
82MAP2K60.54783742
83PBK0.53980432
84ROCK10.52773416
85OXSR10.52760278
86AKT20.50763227
87PRKD10.49529353
88EPHA40.49418214
89CAMK2B0.49272852
90MINK10.48757861
91CAMK2A0.48512165
92GRK60.46678542
93CSNK1A10.46469184
94MAPK150.45935219
95MAPKAPK50.45762804
96PRKACA0.44751188
97CAMK10.44084748
98PAK10.43607523
99RPS6KB20.43535077
100CHEK20.42277525
101BRSK10.42237002
102PAK30.41597752
103ROCK20.41301390
104CSNK2A20.39667885
105ADRBK10.39237786
106PRKCA0.37942557
107TTK0.37475868
108CSNK1A1L0.37101783
109CSNK2A10.36583524
110PLK10.35843300
111MAP3K50.35496505
112KSR20.34843978
113MAP3K80.33665810
114TAOK20.33442991
115UHMK10.33063438
116CSNK1E0.32953188
117PRKAA20.32229367
118PRKG10.31874490
119RAF10.30985434
120TBK10.30831593
121MAPK110.30627720
122MAP3K70.30407145
123CAMKK20.30192777
124PRKACG0.29709900
125PRKCD0.29438295
126PRKCI0.29422094
127TNIK0.28085472
128MAPK120.27508966
129DYRK30.26527198
130PTK2B0.25973230
131STK38L0.25712463
132GRK50.24705431
133RPS6KC10.24521241
134RPS6KL10.24521241
135DAPK10.24406499

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.76265606
2Parkinsons disease_Homo sapiens_hsa050125.32171697
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.37498503
4Alzheimers disease_Homo sapiens_hsa050103.84313136
5Ribosome_Homo sapiens_hsa030103.74266083
6Huntingtons disease_Homo sapiens_hsa050163.65926755
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.46709019
8* Cardiac muscle contraction_Homo sapiens_hsa042603.46662457
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.93549566
10Propanoate metabolism_Homo sapiens_hsa006402.53385237
11Carbon metabolism_Homo sapiens_hsa012002.21585328
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02794809
13Proteasome_Homo sapiens_hsa030502.02772846
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00792978
15Fatty acid degradation_Homo sapiens_hsa000711.95025868
16Pyruvate metabolism_Homo sapiens_hsa006201.88938977
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80797750
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64087211
19Sulfur relay system_Homo sapiens_hsa041221.60293770
20Butanoate metabolism_Homo sapiens_hsa006501.51994464
21Sulfur metabolism_Homo sapiens_hsa009201.50859663
22RNA polymerase_Homo sapiens_hsa030201.48980800
23Fatty acid metabolism_Homo sapiens_hsa012121.33234581
24DNA replication_Homo sapiens_hsa030301.28918683
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25686731
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25258887
27Fatty acid elongation_Homo sapiens_hsa000621.18698706
28Pyrimidine metabolism_Homo sapiens_hsa002401.17414312
29Biosynthesis of amino acids_Homo sapiens_hsa012301.15064344
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12951265
31Peroxisome_Homo sapiens_hsa041460.95384071
32Folate biosynthesis_Homo sapiens_hsa007900.93152339
33Pentose phosphate pathway_Homo sapiens_hsa000300.91065762
34Protein export_Homo sapiens_hsa030600.89573927
35* Metabolic pathways_Homo sapiens_hsa011000.87801385
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87682035
37Glutathione metabolism_Homo sapiens_hsa004800.86723781
38beta-Alanine metabolism_Homo sapiens_hsa004100.85834989
39Nitrogen metabolism_Homo sapiens_hsa009100.84333508
40Mismatch repair_Homo sapiens_hsa034300.83023496
41Dilated cardiomyopathy_Homo sapiens_hsa054140.82254114
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81026296
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.80797627
44Fructose and mannose metabolism_Homo sapiens_hsa000510.79126813
45Galactose metabolism_Homo sapiens_hsa000520.70953149
46Tryptophan metabolism_Homo sapiens_hsa003800.67867952
47Basal transcription factors_Homo sapiens_hsa030220.66434044
48Arginine and proline metabolism_Homo sapiens_hsa003300.66413723
49Phenylalanine metabolism_Homo sapiens_hsa003600.66265005
50PPAR signaling pathway_Homo sapiens_hsa033200.66022697
51Fanconi anemia pathway_Homo sapiens_hsa034600.61867863
52Homologous recombination_Homo sapiens_hsa034400.61186918
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60692640
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59544646
55Fat digestion and absorption_Homo sapiens_hsa049750.59274365
56Starch and sucrose metabolism_Homo sapiens_hsa005000.58470539
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.58453103
58Purine metabolism_Homo sapiens_hsa002300.58265615
59Spliceosome_Homo sapiens_hsa030400.56539446
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55677446
61Vitamin B6 metabolism_Homo sapiens_hsa007500.53206278
62Mineral absorption_Homo sapiens_hsa049780.50139914
63Phototransduction_Homo sapiens_hsa047440.50033128
64Arginine biosynthesis_Homo sapiens_hsa002200.49620541
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49511306
66Tyrosine metabolism_Homo sapiens_hsa003500.49386293
67Synaptic vesicle cycle_Homo sapiens_hsa047210.48234696
68Nucleotide excision repair_Homo sapiens_hsa034200.45284173
69Vitamin digestion and absorption_Homo sapiens_hsa049770.45016310
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.44138646
71Systemic lupus erythematosus_Homo sapiens_hsa053220.40500789
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40437495
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.39298954
74Nicotine addiction_Homo sapiens_hsa050330.38585023
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38391187
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38163129
77Retinol metabolism_Homo sapiens_hsa008300.36908600
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35342206
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33844480
80Collecting duct acid secretion_Homo sapiens_hsa049660.33463378
81Base excision repair_Homo sapiens_hsa034100.32906889
82Caffeine metabolism_Homo sapiens_hsa002320.32814999
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32091508
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31670937
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31167120
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31102761
87Asthma_Homo sapiens_hsa053100.29690027
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29441323
89Rheumatoid arthritis_Homo sapiens_hsa053230.29356341
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28764111
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.27658716
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27084019
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25021699
94Chemical carcinogenesis_Homo sapiens_hsa052040.24636275
95Regulation of autophagy_Homo sapiens_hsa041400.24042550
96One carbon pool by folate_Homo sapiens_hsa006700.23130383
97Arachidonic acid metabolism_Homo sapiens_hsa005900.21745807
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20897968
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20852351
100Vibrio cholerae infection_Homo sapiens_hsa051100.19575084
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.18387693
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18294921
103Linoleic acid metabolism_Homo sapiens_hsa005910.16600715
104Glucagon signaling pathway_Homo sapiens_hsa049220.15422692
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14664029
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14465788
107Bile secretion_Homo sapiens_hsa049760.11992986
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11679144
109Insulin signaling pathway_Homo sapiens_hsa049100.11248025
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.09696892
111Glycerolipid metabolism_Homo sapiens_hsa005610.09008309
112RNA degradation_Homo sapiens_hsa030180.08423622
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08140905
114HIF-1 signaling pathway_Homo sapiens_hsa040660.07496940
115RNA transport_Homo sapiens_hsa030130.06096010
116Selenocompound metabolism_Homo sapiens_hsa004500.05811684
117Histidine metabolism_Homo sapiens_hsa003400.02026004
118Viral myocarditis_Homo sapiens_hsa054160.00800948
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770-0.0357941
120Calcium signaling pathway_Homo sapiens_hsa04020-0.0233018
121Alcoholism_Homo sapiens_hsa05034-0.0164729

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