COX18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.13506832
2proteasome assembly (GO:0043248)5.45116417
3behavioral response to nicotine (GO:0035095)5.37059326
4formation of translation preinitiation complex (GO:0001731)4.65217615
5folic acid metabolic process (GO:0046655)4.53013471
6purine nucleobase biosynthetic process (GO:0009113)4.42212049
7nucleobase biosynthetic process (GO:0046112)4.40128019
8DNA strand elongation involved in DNA replication (GO:0006271)4.31159545
9fucose catabolic process (GO:0019317)4.23002590
10L-fucose metabolic process (GO:0042354)4.23002590
11L-fucose catabolic process (GO:0042355)4.23002590
12telomere maintenance via semi-conservative replication (GO:0032201)4.22365110
13response to pheromone (GO:0019236)4.21892657
14DNA replication initiation (GO:0006270)4.20840049
15water-soluble vitamin biosynthetic process (GO:0042364)4.14382833
16DNA strand elongation (GO:0022616)4.12250480
17ribosome assembly (GO:0042255)4.03925990
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.01153955
19ribosome biogenesis (GO:0042254)3.99772301
20DNA replication checkpoint (GO:0000076)3.91255986
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88395368
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.88234979
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.87928870
24pseudouridine synthesis (GO:0001522)3.86994556
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.85788348
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.84294191
27indole-containing compound catabolic process (GO:0042436)3.82134900
28indolalkylamine catabolic process (GO:0046218)3.82134900
29tryptophan catabolic process (GO:0006569)3.82134900
30telomere maintenance via recombination (GO:0000722)3.77281165
31indolalkylamine metabolic process (GO:0006586)3.73684569
32folic acid-containing compound biosynthetic process (GO:0009396)3.72203508
33detection of light stimulus involved in sensory perception (GO:0050962)3.69675705
34detection of light stimulus involved in visual perception (GO:0050908)3.69675705
35rRNA modification (GO:0000154)3.69427963
36kynurenine metabolic process (GO:0070189)3.69045681
37negative regulation of ligase activity (GO:0051352)3.63998556
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.63998556
39maturation of SSU-rRNA (GO:0030490)3.61870880
40regulation of cellular amino acid metabolic process (GO:0006521)3.61573478
41ribonucleoprotein complex biogenesis (GO:0022613)3.58291764
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.54956975
43mitotic metaphase plate congression (GO:0007080)3.53830812
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53492257
45cellular ketone body metabolic process (GO:0046950)3.53046044
46neural tube formation (GO:0001841)3.50074316
47nucleobase-containing small molecule interconversion (GO:0015949)3.49444210
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46589390
49piRNA metabolic process (GO:0034587)3.46024314
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44169362
51protein deneddylation (GO:0000338)3.43251313
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.41395086
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.41395086
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.41395086
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.39760353
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.39760353
57termination of RNA polymerase III transcription (GO:0006386)3.36984900
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.36984900
59CENP-A containing nucleosome assembly (GO:0034080)3.36700714
60ribosomal large subunit biogenesis (GO:0042273)3.35828389
61signal transduction involved in DNA damage checkpoint (GO:0072422)3.35142848
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35142848
63telomere maintenance via telomere lengthening (GO:0010833)3.34758568
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34476268
65amino acid salvage (GO:0043102)3.32181362
66L-methionine salvage (GO:0071267)3.32181362
67L-methionine biosynthetic process (GO:0071265)3.32181362
68chromatin remodeling at centromere (GO:0031055)3.31868066
69positive regulation of ligase activity (GO:0051351)3.29740282
70mitotic recombination (GO:0006312)3.29501297
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.29217244
72spliceosomal snRNP assembly (GO:0000387)3.29201692
737-methylguanosine mRNA capping (GO:0006370)3.27242691
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26846376
75rRNA processing (GO:0006364)3.26552053
76cell cycle G1/S phase transition (GO:0044843)3.25174695
77G1/S transition of mitotic cell cycle (GO:0000082)3.25174695
78ribosomal small subunit assembly (GO:0000028)3.24664344
79transcription-coupled nucleotide-excision repair (GO:0006283)3.23305284
80tRNA methylation (GO:0030488)3.22376380
81regulation of mitochondrial translation (GO:0070129)3.22341431
82tryptophan metabolic process (GO:0006568)3.21166285
83ketone body metabolic process (GO:1902224)3.20772447
84preassembly of GPI anchor in ER membrane (GO:0016254)3.20329042
85translation (GO:0006412)3.18992290
86reciprocal meiotic recombination (GO:0007131)3.18254663
87reciprocal DNA recombination (GO:0035825)3.18254663
88translational initiation (GO:0006413)3.17913885
897-methylguanosine RNA capping (GO:0009452)3.17347439
90RNA capping (GO:0036260)3.17347439
91oxidative phosphorylation (GO:0006119)3.15831251
92rRNA metabolic process (GO:0016072)3.14737219
93DNA double-strand break processing (GO:0000729)3.14278567
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13750685
95cullin deneddylation (GO:0010388)3.12969341
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.11252137
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.11162960
98nucleotide-excision repair, DNA gap filling (GO:0006297)3.11160157
99deoxyribonucleotide biosynthetic process (GO:0009263)3.10423837
100translational termination (GO:0006415)3.09453911
101DNA replication-independent nucleosome organization (GO:0034724)3.07627279
102DNA replication-independent nucleosome assembly (GO:0006336)3.07627279
103maturation of 5.8S rRNA (GO:0000460)3.06667720
104mitotic nuclear envelope disassembly (GO:0007077)3.06305645
105viral transcription (GO:0019083)3.06103089
106regulation of ubiquitin-protein transferase activity (GO:0051438)3.05595849
107antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05153585
108double-strand break repair via homologous recombination (GO:0000724)3.02587400
109recombinational repair (GO:0000725)3.01726381
110ribosomal small subunit biogenesis (GO:0042274)3.01443150
111cellular component biogenesis (GO:0044085)3.01344047
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00564800
113translational elongation (GO:0006414)3.00216664
114replication fork processing (GO:0031297)2.99100755
115protein complex biogenesis (GO:0070271)2.96802997
1162-deoxyribonucleotide biosynthetic process (GO:0009265)2.95822447
117deoxyribose phosphate biosynthetic process (GO:0046385)2.95822447
118DNA replication-dependent nucleosome organization (GO:0034723)2.95460507
119DNA replication-dependent nucleosome assembly (GO:0006335)2.95460507
120ubiquinone biosynthetic process (GO:0006744)2.93867094
121regulation of ligase activity (GO:0051340)2.93223661
122mitochondrial RNA metabolic process (GO:0000959)2.92630005
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92451064
124rRNA methylation (GO:0031167)2.92357115
125cornea development in camera-type eye (GO:0061303)2.91612325
126regulation of translation in response to stress (GO:0043555)2.91547401
127protein targeting to mitochondrion (GO:0006626)2.91347590
128pteridine-containing compound biosynthetic process (GO:0042559)2.91085305
129protein-cofactor linkage (GO:0018065)2.90289403
130viral mRNA export from host cell nucleus (GO:0046784)2.90199821
131mitochondrial respiratory chain complex assembly (GO:0033108)2.89767941
132pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88135324
133* establishment of protein localization to mitochondrion (GO:0072655)2.87778362
134exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87637173
135photoreceptor cell maintenance (GO:0045494)2.83785798
136RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83596463
137protein K11-linked deubiquitination (GO:0035871)2.82513338
138sulfation (GO:0051923)2.81951780
139regulation of cilium movement (GO:0003352)2.78761231
140ubiquinone metabolic process (GO:0006743)2.78396946
141epithelial cilium movement (GO:0003351)2.78249774
142cilium morphogenesis (GO:0060271)2.77945737
143regulation of hippo signaling (GO:0035330)2.75175341
144platelet dense granule organization (GO:0060155)2.73516819
145axoneme assembly (GO:0035082)2.73281585
146photoreceptor cell development (GO:0042461)2.72957921
147reflex (GO:0060004)2.72644216
148nonmotile primary cilium assembly (GO:0035058)2.72330664
149S-adenosylmethionine metabolic process (GO:0046500)2.72171614
150protein prenylation (GO:0018342)2.68688801
151prenylation (GO:0097354)2.68688801
152* cytochrome complex assembly (GO:0017004)2.68181827
153mitochondrial respiratory chain complex I assembly (GO:0032981)2.67721241
154NADH dehydrogenase complex assembly (GO:0010257)2.67721241
155mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67721241
156* respiratory chain complex IV assembly (GO:0008535)2.65841149
157negative regulation of telomere maintenance (GO:0032205)2.65529824
158kidney morphogenesis (GO:0060993)2.65370413
159behavioral response to ethanol (GO:0048149)2.61735519
160negative regulation of mast cell activation (GO:0033004)2.58677652
161pyrimidine nucleobase catabolic process (GO:0006208)2.57385135
162methionine biosynthetic process (GO:0009086)2.57015152
163indole-containing compound metabolic process (GO:0042430)2.53531349
164amine catabolic process (GO:0009310)2.53261359
165cellular biogenic amine catabolic process (GO:0042402)2.53261359
166synaptic transmission, cholinergic (GO:0007271)2.52753718
167nucleotide transmembrane transport (GO:1901679)2.51771128
168negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51712672
169cellular response to ATP (GO:0071318)2.51542481
170drug catabolic process (GO:0042737)2.51527284
171exogenous drug catabolic process (GO:0042738)2.51208567
172negative regulation of cell aging (GO:0090344)2.50895253
173mannosylation (GO:0097502)2.50285361
174DNA methylation involved in gamete generation (GO:0043046)2.49925106
175GPI anchor metabolic process (GO:0006505)2.47893822
176retinal cone cell development (GO:0046549)2.47178551
177protein localization to cilium (GO:0061512)2.46978053
178meiotic chromosome segregation (GO:0045132)2.46455324
179protein K6-linked ubiquitination (GO:0085020)2.46167768
180neuronal action potential (GO:0019228)2.46063890
181nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45856183
182gamma-aminobutyric acid transport (GO:0015812)2.45339226
183regulation of action potential (GO:0098900)2.44655073
184G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44476630
185regulation of posttranscriptional gene silencing (GO:0060147)2.43969406
186regulation of gene silencing by miRNA (GO:0060964)2.43969406
187regulation of gene silencing by RNA (GO:0060966)2.43969406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.68192175
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.46961348
3ZNF274_21170338_ChIP-Seq_K562_Hela4.16450182
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.02659279
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.63471097
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61537537
7VDR_22108803_ChIP-Seq_LS180_Human3.51081946
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.42274655
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.27778373
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.21857986
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.11828377
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92670306
13IGF1R_20145208_ChIP-Seq_DFB_Human2.90508818
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89889517
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85808928
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79120430
17GBX2_23144817_ChIP-Seq_PC3_Human2.74974025
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69755239
19EWS_26573619_Chip-Seq_HEK293_Human2.65787744
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64704730
21FUS_26573619_Chip-Seq_HEK293_Human2.52133846
22TAF15_26573619_Chip-Seq_HEK293_Human2.49843366
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47886350
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.45941875
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44017036
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40900928
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39045808
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39042930
29VDR_23849224_ChIP-Seq_CD4+_Human2.37429069
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37177954
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.37075795
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.32586271
33DCP1A_22483619_ChIP-Seq_HELA_Human2.29779834
34* SALL1_21062744_ChIP-ChIP_HESCs_Human2.29637991
35EZH2_22144423_ChIP-Seq_EOC_Human2.27303338
36* XRN2_22483619_ChIP-Seq_HELA_Human2.26453334
37* GABP_19822575_ChIP-Seq_HepG2_Human2.14685675
38ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12343492
39CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11410428
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07885119
41YY1_21170310_ChIP-Seq_MESCs_Mouse2.06595243
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05607920
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04344449
44P300_19829295_ChIP-Seq_ESCs_Human2.02704270
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.99290456
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97695426
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97175506
48FOXP3_21729870_ChIP-Seq_TREG_Human1.96959851
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95698236
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92497965
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92146126
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91805529
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90099891
54ER_23166858_ChIP-Seq_MCF-7_Human1.89701544
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88750849
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87936299
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85358387
58* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84704701
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.84150842
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76646829
61TTF2_22483619_ChIP-Seq_HELA_Human1.73818669
62AR_21909140_ChIP-Seq_LNCAP_Human1.73647007
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72652009
64* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72050560
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66477219
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62816561
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58275533
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58093869
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55820375
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.55546561
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54903857
72* TP53_22573176_ChIP-Seq_HFKS_Human1.53217732
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51722977
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51189879
75* STAT3_23295773_ChIP-Seq_U87_Human1.50362092
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50268024
77BCAT_22108803_ChIP-Seq_LS180_Human1.47626897
78IRF1_19129219_ChIP-ChIP_H3396_Human1.47498858
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46873392
80KDM5A_27292631_Chip-Seq_BREAST_Human1.46158296
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45676652
82* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42711719
83* CBP_20019798_ChIP-Seq_JUKART_Human1.42711719
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41912616
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.41011678
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40686530
87SOX2_19829295_ChIP-Seq_ESCs_Human1.38656189
88NANOG_19829295_ChIP-Seq_ESCs_Human1.38656189
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37273373
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35062547
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34967761
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34790901
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34029499
94* ELK1_19687146_ChIP-ChIP_HELA_Human1.33741156
95TCF4_23295773_ChIP-Seq_U87_Human1.33632634
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.32906844
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32727036
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31488818
99AR_25329375_ChIP-Seq_VCAP_Human1.31144226
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.30742351
101CIITA_25753668_ChIP-Seq_RAJI_Human1.30687407
102TFEB_21752829_ChIP-Seq_HELA_Human1.29622886
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28755521
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.28622224
105TCF4_22108803_ChIP-Seq_LS180_Human1.27993145
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26618607
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25293324
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.25190155
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24388105
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24388105
111* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23689219
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22714370
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21735412
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21354312
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.21065085
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21065085
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21044784
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21031626
119NOTCH1_21737748_ChIP-Seq_TLL_Human1.20827156
120EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19261204
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19077722
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18636820
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18427009
124RUNX2_22187159_ChIP-Seq_PCA_Human1.17524558
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17142190
126RNF2_27304074_Chip-Seq_NSC_Mouse1.16566462
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16474979
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16190860
129MYC_22102868_ChIP-Seq_BL_Human1.14414592
130POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13832480
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12879073
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12612456
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12223012
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12114738
135CBX2_27304074_Chip-Seq_ESCs_Mouse1.11880778
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11510528
137ZNF263_19887448_ChIP-Seq_K562_Human1.11376364
138FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10917719
139AR_20517297_ChIP-Seq_VCAP_Human1.09813408
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09369762
141CRX_20693478_ChIP-Seq_RETINA_Mouse1.09077510
142CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08125041
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07981516
144AR_21572438_ChIP-Seq_LNCaP_Human1.07474356
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07207976
146FLI1_21867929_ChIP-Seq_TH2_Mouse1.06750188
147SMAD4_21741376_ChIP-Seq_EPCs_Human1.06617395
148GATA3_21878914_ChIP-Seq_MCF-7_Human1.05421793
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05018868
150* NCOR_22424771_ChIP-Seq_293T_Human1.04473834
151CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04377900
152PRDM14_20953172_ChIP-Seq_ESCs_Human1.04032835
153SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03747016
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03376090
155HOXB7_26014856_ChIP-Seq_BT474_Human1.02107690
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01913629
157REST_21632747_ChIP-Seq_MESCs_Mouse1.01318926
158ELK1_22589737_ChIP-Seq_MCF10A_Human1.00878164
159AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00570932
160SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00021958
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.99433354
162ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98336471
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97753229
164CDX2_22108803_ChIP-Seq_LS180_Human0.97661721
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97461049
166P53_22387025_ChIP-Seq_ESCs_Mouse0.97114161
167TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96912518
168* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95213618
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94639881
170OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94450473
171HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94143615
172SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93750678
173MYC_18940864_ChIP-ChIP_HL60_Human0.93459127
174PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91253032
175KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90807015
176CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88778253
177* SPI1_23547873_ChIP-Seq_NB4_Human0.88471211
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87986624
179* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87021795
180* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87014397
181SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86114324
182TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85984871
183NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85950241
184ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85580496
185* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85429939
186TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83430173
187CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83099900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.76988695
2MP0004957_abnormal_blastocyst_morpholog4.92732018
3MP0003111_abnormal_nucleus_morphology4.45634263
4MP0010094_abnormal_chromosome_stability3.82768227
5MP0003077_abnormal_cell_cycle3.51301219
6MP0003806_abnormal_nucleotide_metabolis3.51287650
7MP0008058_abnormal_DNA_repair3.08466056
8MP0005645_abnormal_hypothalamus_physiol2.90144373
9MP0002102_abnormal_ear_morphology2.81544854
10MP0008057_abnormal_DNA_replication2.70613483
11MP0008932_abnormal_embryonic_tissue2.68772188
12MP0000569_abnormal_digit_pigmentation2.67315288
13MP0009840_abnormal_foam_cell2.62604479
14MP0003718_maternal_effect2.53761162
15MP0002837_dystrophic_cardiac_calcinosis2.41825033
16MP0005551_abnormal_eye_electrophysiolog2.35592108
17MP0003136_yellow_coat_color2.33009927
18MP0010352_gastrointestinal_tract_polyps2.28341547
19MP0008007_abnormal_cellular_replicative2.25889640
20MP0001730_embryonic_growth_arrest2.18060421
21MP0005174_abnormal_tail_pigmentation2.17036963
22MP0004043_abnormal_pH_regulation2.13403677
23MP0003646_muscle_fatigue2.08584041
24MP0003186_abnormal_redox_activity2.06311443
25MP0001968_abnormal_touch/_nociception2.05095852
26MP0002638_abnormal_pupillary_reflex2.03106831
27MP0006035_abnormal_mitochondrial_morpho1.98418775
28MP0006072_abnormal_retinal_apoptosis1.96625161
29MP0002396_abnormal_hematopoietic_system1.95673027
30MP0006036_abnormal_mitochondrial_physio1.94133528
31MP0005253_abnormal_eye_physiology1.84601313
32MP0003011_delayed_dark_adaptation1.84408330
33MP0003786_premature_aging1.83879253
34MP0002736_abnormal_nociception_after1.79952072
35MP0000358_abnormal_cell_content/1.70555068
36MP0003123_paternal_imprinting1.70359730
37MP0008877_abnormal_DNA_methylation1.69905715
38MP0000350_abnormal_cell_proliferation1.68131185
39MP0006292_abnormal_olfactory_placode1.68027044
40MP0008875_abnormal_xenobiotic_pharmacok1.67104412
41MP0000490_abnormal_crypts_of1.64594575
42MP0001697_abnormal_embryo_size1.62695312
43MP0002876_abnormal_thyroid_physiology1.62614874
44MP0008872_abnormal_physiological_respon1.60847872
45MP0009046_muscle_twitch1.58815264
46MP0002234_abnormal_pharynx_morphology1.58780480
47MP0001501_abnormal_sleep_pattern1.56868522
48MP0002080_prenatal_lethality1.55254924
49MP0004145_abnormal_muscle_electrophysio1.51306494
50MP0000372_irregular_coat_pigmentation1.46857912
51MP0005380_embryogenesis_phenotype1.45520385
52MP0001672_abnormal_embryogenesis/_devel1.45520385
53MP0006276_abnormal_autonomic_nervous1.45376814
54MP0002019_abnormal_tumor_incidence1.42829703
55MP0000631_abnormal_neuroendocrine_gland1.42212903
56MP0004142_abnormal_muscle_tone1.39941419
57MP0009745_abnormal_behavioral_response1.39837928
58MP0003787_abnormal_imprinting1.38480792
59MP0009379_abnormal_foot_pigmentation1.37913762
60MP0009333_abnormal_splenocyte_physiolog1.36979297
61MP0001764_abnormal_homeostasis1.35105485
62MP0005171_absent_coat_pigmentation1.34829529
63MP0002272_abnormal_nervous_system1.34240949
64MP0000427_abnormal_hair_cycle1.33288862
65MP0005397_hematopoietic_system_phenotyp1.32154226
66MP0001545_abnormal_hematopoietic_system1.32154226
67MP0002938_white_spotting1.32092576
68MP0003984_embryonic_growth_retardation1.31420342
69MP0000313_abnormal_cell_death1.29757382
70MP0003221_abnormal_cardiomyocyte_apopto1.27892625
71MP0002088_abnormal_embryonic_growth/wei1.26050116
72MP0008995_early_reproductive_senescence1.26031703
73MP0005423_abnormal_somatic_nervous1.26025333
74MP0002160_abnormal_reproductive_system1.24940706
75MP0001529_abnormal_vocalization1.23238285
76MP0003880_abnormal_central_pattern1.22890970
77MP0004215_abnormal_myocardial_fiber1.21371231
78MP0004133_heterotaxia1.18660075
79MP0001485_abnormal_pinna_reflex1.18144015
80MP0002086_abnormal_extraembryonic_tissu1.14767973
81MP0005386_behavior/neurological_phenoty1.14302395
82MP0004924_abnormal_behavior1.14302395
83MP0002928_abnormal_bile_duct1.12958695
84MP0005646_abnormal_pituitary_gland1.12671082
85MP0005266_abnormal_metabolism1.12517402
86MP0002735_abnormal_chemical_nociception1.12100923
87MP0001661_extended_life_span1.09570783
88MP0003195_calcinosis1.09533096
89MP0000858_altered_metastatic_potential1.09125462
90MP0002139_abnormal_hepatobiliary_system1.08033649
91MP0010386_abnormal_urinary_bladder1.06923941
92MP0005075_abnormal_melanosome_morpholog1.06246801
93MP0000538_abnormal_urinary_bladder1.06143137
94MP0002085_abnormal_embryonic_tissue1.05675686
95MP0005389_reproductive_system_phenotype1.05004816
96MP0001984_abnormal_olfaction1.04555703
97MP0003763_abnormal_thymus_physiology1.04095599
98MP0001145_abnormal_male_reproductive1.03683497
99MP0001970_abnormal_pain_threshold1.02786439
100MP0003137_abnormal_impulse_conducting1.02145279
101MP0002722_abnormal_immune_system1.01691430
102MP0000015_abnormal_ear_pigmentation1.01219978
103MP0001486_abnormal_startle_reflex1.01141641
104MP0002210_abnormal_sex_determination1.01025186
105MP0008775_abnormal_heart_ventricle1.00826180
106MP0000689_abnormal_spleen_morphology0.99770553
107MP0001853_heart_inflammation0.98625661
108MP0002751_abnormal_autonomic_nervous0.97786505
109MP0008789_abnormal_olfactory_epithelium0.97252386
110MP0002163_abnormal_gland_morphology0.95904821
111MP0005395_other_phenotype0.95029798
112MP0001929_abnormal_gametogenesis0.94475926
113MP0002572_abnormal_emotion/affect_behav0.93779357
114MP0005410_abnormal_fertilization0.93172935
115MP0005083_abnormal_biliary_tract0.93085881
116MP0003121_genomic_imprinting0.91724200
117MP0005195_abnormal_posterior_eye0.91502521
118MP0000750_abnormal_muscle_regeneration0.90216679
119MP0000653_abnormal_sex_gland0.90064679
120MP0002398_abnormal_bone_marrow0.90015508
121MP0004885_abnormal_endolymph0.89628128
122MP0001324_abnormal_eye_pigmentation0.88978343
123MP0002269_muscular_atrophy0.88736848
124MP0003937_abnormal_limbs/digits/tail_de0.88687092
125MP0000703_abnormal_thymus_morphology0.88581688
126MP0002138_abnormal_hepatobiliary_system0.87876711
127MP0002084_abnormal_developmental_patter0.87325963
128MP0004130_abnormal_muscle_cell0.86939155
129MP0001119_abnormal_female_reproductive0.86862356
130MP0003698_abnormal_male_reproductive0.86210400
131MP0004197_abnormal_fetal_growth/weight/0.85977531
132MP0005319_abnormal_enzyme/_coenzyme0.85387928
133MP0002557_abnormal_social/conspecific_i0.85353679
134MP0001188_hyperpigmentation0.84941233
135MP0002254_reproductive_system_inflammat0.84242493
136MP0005332_abnormal_amino_acid0.83925424
137MP0005379_endocrine/exocrine_gland_phen0.83091621
138MP0005451_abnormal_body_composition0.82709436
139MP0003315_abnormal_perineum_morphology0.82319337
140MP0003252_abnormal_bile_duct0.81504499
141MP0002067_abnormal_sensory_capabilities0.80865104
142MP0005220_abnormal_exocrine_pancreas0.80156216
143MP0001293_anophthalmia0.79519366
144MP0005367_renal/urinary_system_phenotyp0.79099570
145MP0000516_abnormal_urinary_system0.79099570
146MP0000383_abnormal_hair_follicle0.78922207
147MP0005384_cellular_phenotype0.78769743
148MP0008260_abnormal_autophagy0.78414930
149MP0001986_abnormal_taste_sensitivity0.78288956
150MP0004808_abnormal_hematopoietic_stem0.77627476
151MP0002752_abnormal_somatic_nervous0.77151736
152MP0003567_abnormal_fetal_cardiomyocyte0.76497234
153MP0000598_abnormal_liver_morphology0.75193954
154MP0005330_cardiomyopathy0.74214984
155MP0001919_abnormal_reproductive_system0.73541898
156MP0002429_abnormal_blood_cell0.73311316
157MP0004147_increased_porphyrin_level0.70006807
158MP0001727_abnormal_embryo_implantation0.68364045
159MP0010030_abnormal_orbit_morphology0.67813729
160MP0003699_abnormal_female_reproductive0.67086305
161MP0005671_abnormal_response_to0.66869631
162MP0005376_homeostasis/metabolism_phenot0.66845058
163MP0000685_abnormal_immune_system0.66115772
164MP0010307_abnormal_tumor_latency0.65575207
165MP0005085_abnormal_gallbladder_physiolo0.64989257
166MP0005360_urolithiasis0.64678514
167MP0005023_abnormal_wound_healing0.64572659
168MP0005621_abnormal_cell_physiology0.63526575
169MP0003656_abnormal_erythrocyte_physiolo0.63250848
170MP0002970_abnormal_white_adipose0.61027367
171MP0003879_abnormal_hair_cell0.60982756
172MP0000609_abnormal_liver_physiology0.60324145
173MP0004084_abnormal_cardiac_muscle0.59660389
174MP0000716_abnormal_immune_system0.59008333
175MP0005365_abnormal_bile_salt0.57863740
176MP0005084_abnormal_gallbladder_morpholo0.57720947

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.67670436
2Pancreatic cysts (HP:0001737)4.18394791
3Congenital stationary night blindness (HP:0007642)4.05724882
4Breast hypoplasia (HP:0003187)3.97577963
5Abnormality of cells of the erythroid lineage (HP:0012130)3.89208285
6Abnormal number of erythroid precursors (HP:0012131)3.80184866
7Hepatic necrosis (HP:0002605)3.80140501
8Pancreatic fibrosis (HP:0100732)3.73362778
9Hepatocellular necrosis (HP:0001404)3.72534923
10Abnormality of midbrain morphology (HP:0002418)3.68833018
11Molar tooth sign on MRI (HP:0002419)3.68833018
12Microretrognathia (HP:0000308)3.64636027
13True hermaphroditism (HP:0010459)3.61321983
14Aplastic anemia (HP:0001915)3.58080020
15Nephronophthisis (HP:0000090)3.46507143
16Attenuation of retinal blood vessels (HP:0007843)3.41871179
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35487076
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.33322420
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.33322420
20Increased serum lactate (HP:0002151)3.26757048
21Cerebral hypomyelination (HP:0006808)3.22766608
22Chronic hepatic failure (HP:0100626)3.19346108
23Oral leukoplakia (HP:0002745)3.11377801
24Rough bone trabeculation (HP:0100670)3.10234375
25Carpal bone hypoplasia (HP:0001498)3.06208573
26Increased CSF lactate (HP:0002490)3.01360682
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99959074
28Abnormality of the renal medulla (HP:0100957)2.96484306
29Abnormality of the renal cortex (HP:0011035)2.95621630
30Megaloblastic anemia (HP:0001889)2.95504610
31Reticulocytopenia (HP:0001896)2.94172376
32Hyperventilation (HP:0002883)2.93393523
33Mitochondrial inheritance (HP:0001427)2.93340539
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.85613963
35Progressive muscle weakness (HP:0003323)2.82464848
36Acute necrotizing encephalopathy (HP:0006965)2.79816742
37Type II lissencephaly (HP:0007260)2.79163753
38Abnormality of alanine metabolism (HP:0010916)2.79157394
39Hyperalaninemia (HP:0003348)2.79157394
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79157394
41Degeneration of anterior horn cells (HP:0002398)2.78821750
42Abnormality of the anterior horn cell (HP:0006802)2.78821750
43Medial flaring of the eyebrow (HP:0010747)2.77091653
44Tubular atrophy (HP:0000092)2.75522883
45Lactic acidosis (HP:0003128)2.73326058
46Poor head control (HP:0002421)2.72109376
47Macrocytic anemia (HP:0001972)2.71450595
48Progressive inability to walk (HP:0002505)2.70645516
49Abnormal mitochondria in muscle tissue (HP:0008316)2.69921127
50Prolonged neonatal jaundice (HP:0006579)2.69347563
51Type I transferrin isoform profile (HP:0003642)2.67844028
52Increased hepatocellular lipid droplets (HP:0006565)2.66389181
53Abnormal biliary tract physiology (HP:0012439)2.65430498
54Bile duct proliferation (HP:0001408)2.65430498
55Exertional dyspnea (HP:0002875)2.63238404
56Patellar aplasia (HP:0006443)2.61540924
57Abolished electroretinogram (ERG) (HP:0000550)2.59372247
58Absent thumb (HP:0009777)2.57252342
59Lipid accumulation in hepatocytes (HP:0006561)2.56677519
60Pendular nystagmus (HP:0012043)2.56621877
61Multiple enchondromatosis (HP:0005701)2.56182558
62Inability to walk (HP:0002540)2.53512088
63Methylmalonic acidemia (HP:0002912)2.52576925
64Secondary amenorrhea (HP:0000869)2.50079958
65Hypobetalipoproteinemia (HP:0003563)2.49027902
66CNS demyelination (HP:0007305)2.48401756
67Decreased central vision (HP:0007663)2.48201791
68Acute encephalopathy (HP:0006846)2.48200253
69Unsteady gait (HP:0002317)2.46298646
70Emotional lability (HP:0000712)2.45983696
71Aplasia/Hypoplasia of the patella (HP:0006498)2.44637601
72Polydipsia (HP:0001959)2.44604743
73Abnormal drinking behavior (HP:0030082)2.44604743
74Cystic liver disease (HP:0006706)2.42148160
75Renal cortical cysts (HP:0000803)2.41209991
76Microvesicular hepatic steatosis (HP:0001414)2.41178386
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.40994569
78Dicarboxylic aciduria (HP:0003215)2.40328670
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40328670
80Selective tooth agenesis (HP:0001592)2.40126086
81Gaze-evoked nystagmus (HP:0000640)2.38666537
82Bony spicule pigmentary retinopathy (HP:0007737)2.35246008
83Abnormal rod and cone electroretinograms (HP:0008323)2.33898328
84Abnormality of the pons (HP:0007361)2.31589339
85Cerebellar dysplasia (HP:0007033)2.29832321
86Lethargy (HP:0001254)2.29689011
87Trismus (HP:0000211)2.29054973
88Chorioretinal atrophy (HP:0000533)2.28056654
89Premature ovarian failure (HP:0008209)2.27980690
90Hypoplasia of the pons (HP:0012110)2.27807440
91Abnormal trabecular bone morphology (HP:0100671)2.27713933
92Increased intramyocellular lipid droplets (HP:0012240)2.27015895
93Pallor (HP:0000980)2.26614607
94Nausea (HP:0002018)2.26202851
95Abnormality of the preputium (HP:0100587)2.25690227
96Genetic anticipation (HP:0003743)2.25027092
97Lissencephaly (HP:0001339)2.23920859
98Sclerocornea (HP:0000647)2.23209235
99Respiratory failure (HP:0002878)2.23049943
100Exercise intolerance (HP:0003546)2.22761042
101Respiratory difficulties (HP:0002880)2.20324378
102Absent radius (HP:0003974)2.19948502
103Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19799164
1043-Methylglutaconic aciduria (HP:0003535)2.18126789
105Male pseudohermaphroditism (HP:0000037)2.17428148
106Abnormality of serum amino acid levels (HP:0003112)2.17316902
107Gait imbalance (HP:0002141)2.15580168
108Abnormality of the umbilical cord (HP:0010881)2.14597569
109Ketoacidosis (HP:0001993)2.13368619
110Pancytopenia (HP:0001876)2.12869875
111Bone marrow hypocellularity (HP:0005528)2.12767557
112Cerebral edema (HP:0002181)2.11717915
113Meckel diverticulum (HP:0002245)2.11188112
114Increased muscle lipid content (HP:0009058)2.11006003
115Congenital primary aphakia (HP:0007707)2.10913767
116Supernumerary spleens (HP:0009799)2.10662244
117Protruding tongue (HP:0010808)2.09394635
118Abnormality of pyrimidine metabolism (HP:0004353)2.09332385
119Hyperglycinemia (HP:0002154)2.07651420
120Abnormality of the ileum (HP:0001549)2.07137476
121Broad-based gait (HP:0002136)2.06895097
122Congenital hepatic fibrosis (HP:0002612)2.06562941
123CNS hypomyelination (HP:0003429)2.05117618
124Sparse eyelashes (HP:0000653)2.03439966
125Concave nail (HP:0001598)2.02840410
126Premature graying of hair (HP:0002216)2.02807824
127Methylmalonic aciduria (HP:0012120)2.02080911
128Large for gestational age (HP:0001520)2.01275538
129Nephrogenic diabetes insipidus (HP:0009806)2.00520764
130Reduced antithrombin III activity (HP:0001976)1.99752921
131Aplasia involving forearm bones (HP:0009822)1.99297896
132Absent forearm bone (HP:0003953)1.99297896
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.99276453
134Generalized aminoaciduria (HP:0002909)1.99202257
135Hypothermia (HP:0002045)1.98983423
136Abnormality of the labia minora (HP:0012880)1.98894393
137Ketosis (HP:0001946)1.98122741
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.97876118
139Hypoalbuminemia (HP:0003073)1.96259309
140Abnormal albumin level (HP:0012116)1.96259309
141Abnormal protein glycosylation (HP:0012346)1.95847008
142Abnormal glycosylation (HP:0012345)1.95847008
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95847008
144Abnormal protein N-linked glycosylation (HP:0012347)1.95847008
145Atrophy/Degeneration involving motor neurons (HP:0007373)1.93523944
146Anencephaly (HP:0002323)1.92916616
147Progressive macrocephaly (HP:0004481)1.92117571
148Abnormality of the heme biosynthetic pathway (HP:0010472)1.91929011
149Death in infancy (HP:0001522)1.91347577
150Absent speech (HP:0001344)1.90557287
151Tachypnea (HP:0002789)1.90484273
152Polyuria (HP:0000103)1.89921597
153Rib fusion (HP:0000902)1.88713578
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.88572330
155Small hand (HP:0200055)1.87596099
156Genital tract atresia (HP:0001827)1.85854634
157Abnormality of chromosome stability (HP:0003220)1.85514585
158Squamous cell carcinoma (HP:0002860)1.84088529
159Horseshoe kidney (HP:0000085)1.83558501
160Hyperammonemia (HP:0001987)1.82030142
161Facial diplegia (HP:0001349)1.81572625
162Vaginal atresia (HP:0000148)1.80663613
163Abnormality of the fetal cardiovascular system (HP:0010948)1.80447843
164Single umbilical artery (HP:0001195)1.80447843
165Hyperglycinuria (HP:0003108)1.78591741
166Pachygyria (HP:0001302)1.77169726
167Decreased circulating renin level (HP:0003351)1.77095532
168Fair hair (HP:0002286)1.76815696
169Optic disc pallor (HP:0000543)1.75722075
170Furrowed tongue (HP:0000221)1.74914982
171Postaxial foot polydactyly (HP:0001830)1.73577209
172Increased corneal curvature (HP:0100692)1.73573031
173Keratoconus (HP:0000563)1.73573031
174Abnormality of vitamin B metabolism (HP:0004340)1.71409575
175Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70929364
176Stomach cancer (HP:0012126)1.70464111
177Intestinal atresia (HP:0011100)1.70095821
178Febrile seizures (HP:0002373)1.69848623
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.69501132
180Clumsiness (HP:0002312)1.67753388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.62102241
2BUB14.90108261
3WEE14.19170260
4EPHA23.41007826
5NME23.30425071
6EIF2AK32.98248255
7WNK42.86780326
8EIF2AK12.79996743
9STK162.76490991
10PLK42.66007893
11BMPR1B2.64584402
12WNK32.42547806
13NUAK12.41958378
14NEK22.37710772
15CDC72.36679039
16PIM22.28567122
17MAP4K22.25111093
18TESK22.24369404
19BRSK22.21222373
20CASK2.18405046
21GRK12.10003235
22STK392.02735578
23KDR1.97737056
24BRAF1.92271094
25BCKDK1.91690348
26TTK1.88352212
27ARAF1.87089640
28PLK11.80776090
29MAP3K111.80541596
30TAOK31.77838469
31NEK11.76290860
32MAPK131.73866915
33SRPK11.72617681
34DYRK31.68306162
35INSRR1.67843134
36RPS6KA41.64034576
37TRIM281.59636758
38TNIK1.55497078
39RPS6KB21.53874600
40ACVR1B1.51653984
41AURKA1.51463449
42MAP3K41.50154489
43CDK71.35657491
44OXSR11.34486915
45TXK1.33783945
46VRK11.32696976
47AURKB1.28058578
48TAOK11.24904889
49CAMKK21.23633281
50MAP2K31.21090181
51MAP3K81.18147266
52BRSK11.16526965
53SCYL21.15219964
54ZAK1.12864080
55STK241.12359576
56MST41.08868879
57TSSK61.08061984
58NME11.04182575
59LATS21.03672755
60RAF11.02898637
61ADRBK10.99950789
62ICK0.99343673
63MUSK0.99032138
64CHEK20.98426583
65TLK10.97302211
66TESK10.97003598
67MAP3K30.96023098
68CCNB10.93442412
69PRKCE0.91968246
70PAK30.91967311
71PHKG20.89853720
72PHKG10.89853720
73DAPK20.89656855
74IRAK30.87743599
75PRKCG0.87656525
76CSNK1G20.87459584
77MAP4K10.86780464
78ATR0.86246765
79ERBB30.84915529
80TGFBR10.84668562
81CSNK1G10.83859717
82PLK30.83704549
83MAPKAPK30.83147490
84BCR0.81932533
85TAOK20.81350610
86CDK40.80864522
87FLT30.79825674
88MARK10.79423708
89PRKCI0.78887571
90STK38L0.78399389
91MAP3K50.77818559
92ABL20.76069731
93CSNK1G30.73964228
94PLK20.72884954
95PASK0.72408870
96PRKCQ0.72372315
97BLK0.71499012
98PAK10.70885861
99MAP3K60.70563558
100PINK10.67014523
101AKT30.66520833
102MAP2K70.66143614
103MAPK150.65809442
104PIM10.65598927
105STK30.64889818
106CSNK1A1L0.63418541
107OBSCN0.62671742
108CSNK2A10.61224171
109PAK40.61095269
110FGFR20.60258039
111GRK60.60197405
112STK100.59600834
113PDK30.57029430
114PDK40.57029430
115CSNK2A20.54568272
116CHEK10.54068950
117LIMK10.53869848
118EIF2AK20.52388081
119CDK80.51166982
120ZAP700.50874684
121ERN10.48751298
122RPS6KA50.48742692
123MOS0.47710135
124MAPKAPK50.47434352
125DYRK20.46058904
126CDK20.46048625
127DAPK10.45950346
128CAMK10.45596811
129MAP2K60.42269901
130CAMK1D0.41174753
131PIK3CA0.41112505
132TEC0.40321913
133IKBKB0.40192024
134MAPK110.37571731
135FER0.37206854
136PRKACA0.37179534
137CSNK1A10.37064088
138PBK0.36392875
139CAMK1G0.36090242
140CSNK1D0.35640068
141STK40.35487503
142CAMK2A0.35458010
143PRKAA10.34895839
144IRAK40.34721563
145MATK0.33647033
146TAF10.33258362
147NLK0.31775387
148PKN10.30629742
149STK110.30112192
150MKNK10.29828601
151MARK30.29760273
152NTRK30.29688102
153PRKAA20.29434789
154TNK20.29059436
155ILK0.28888204
156ATM0.28033145
157TRPM70.27343514
158IRAK10.27027749
159CAMK2G0.26701415
160PDK20.26446846
161PNCK0.25178548
162LRRK20.24331099
163MKNK20.23020003
164AKT20.22328912
165ADRBK20.20832859

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.56705349
2DNA replication_Homo sapiens_hsa030304.47860956
3RNA polymerase_Homo sapiens_hsa030203.65709791
4Mismatch repair_Homo sapiens_hsa034303.58993878
5Ribosome_Homo sapiens_hsa030103.55236114
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40983492
7Pyrimidine metabolism_Homo sapiens_hsa002402.92932194
8Base excision repair_Homo sapiens_hsa034102.78608763
9Nucleotide excision repair_Homo sapiens_hsa034202.72461923
10RNA transport_Homo sapiens_hsa030132.68063242
11Phototransduction_Homo sapiens_hsa047442.52995963
12Homologous recombination_Homo sapiens_hsa034402.47308040
13Spliceosome_Homo sapiens_hsa030402.41713165
14Butanoate metabolism_Homo sapiens_hsa006502.31603203
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29865488
16Nitrogen metabolism_Homo sapiens_hsa009102.25755377
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.25220737
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21585765
19One carbon pool by folate_Homo sapiens_hsa006702.10124147
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04442843
21Folate biosynthesis_Homo sapiens_hsa007902.03743055
22Cell cycle_Homo sapiens_hsa041102.02746272
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90080963
24Tryptophan metabolism_Homo sapiens_hsa003801.87743725
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81535629
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76726739
27Protein export_Homo sapiens_hsa030601.76380411
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76030633
29Basal transcription factors_Homo sapiens_hsa030221.69842333
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66948923
31Nicotine addiction_Homo sapiens_hsa050331.66412232
32RNA degradation_Homo sapiens_hsa030181.64617364
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54706055
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50221528
35Parkinsons disease_Homo sapiens_hsa050121.50087020
36Oxidative phosphorylation_Homo sapiens_hsa001901.48330891
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46097053
38Ether lipid metabolism_Homo sapiens_hsa005651.44741128
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44693278
40Purine metabolism_Homo sapiens_hsa002301.44514365
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.41450162
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.39763538
43Fanconi anemia pathway_Homo sapiens_hsa034601.37743951
44Vitamin B6 metabolism_Homo sapiens_hsa007501.36671422
45Taste transduction_Homo sapiens_hsa047421.35823434
46Pentose phosphate pathway_Homo sapiens_hsa000301.35454149
47p53 signaling pathway_Homo sapiens_hsa041151.31915802
48Caffeine metabolism_Homo sapiens_hsa002321.30963605
49Huntingtons disease_Homo sapiens_hsa050161.30467417
50Sulfur relay system_Homo sapiens_hsa041221.26735773
51Non-homologous end-joining_Homo sapiens_hsa034501.22307950
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21160405
53Biosynthesis of amino acids_Homo sapiens_hsa012301.20774915
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18629588
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18512261
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13902308
57Carbon metabolism_Homo sapiens_hsa012001.11552063
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05249959
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04803971
60Chemical carcinogenesis_Homo sapiens_hsa052041.04528354
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.03767808
62Epstein-Barr virus infection_Homo sapiens_hsa051690.96425794
63Retinol metabolism_Homo sapiens_hsa008300.95410630
64mRNA surveillance pathway_Homo sapiens_hsa030150.95091424
65Olfactory transduction_Homo sapiens_hsa047400.91040233
66Fatty acid metabolism_Homo sapiens_hsa012120.90933954
67ABC transporters_Homo sapiens_hsa020100.89464181
68Selenocompound metabolism_Homo sapiens_hsa004500.87495407
69Sulfur metabolism_Homo sapiens_hsa009200.86922567
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.86171695
71Glutathione metabolism_Homo sapiens_hsa004800.85604998
72Morphine addiction_Homo sapiens_hsa050320.85054703
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82030137
74Fructose and mannose metabolism_Homo sapiens_hsa000510.81893808
75Regulation of autophagy_Homo sapiens_hsa041400.79496028
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79345236
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79026085
78Glycerolipid metabolism_Homo sapiens_hsa005610.74282411
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71720995
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.71297791
81Serotonergic synapse_Homo sapiens_hsa047260.67405417
82Circadian entrainment_Homo sapiens_hsa047130.67266487
83Metabolic pathways_Homo sapiens_hsa011000.67218529
84Alzheimers disease_Homo sapiens_hsa050100.65738319
85Galactose metabolism_Homo sapiens_hsa000520.61956150
86Insulin secretion_Homo sapiens_hsa049110.61442091
87Lysine degradation_Homo sapiens_hsa003100.61217069
88Ovarian steroidogenesis_Homo sapiens_hsa049130.58660547
89Steroid biosynthesis_Homo sapiens_hsa001000.57914364
90Oocyte meiosis_Homo sapiens_hsa041140.56996223
91Thyroid cancer_Homo sapiens_hsa052160.55490013
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55048358
93Antigen processing and presentation_Homo sapiens_hsa046120.54582687
94Calcium signaling pathway_Homo sapiens_hsa040200.53452339
95Arginine and proline metabolism_Homo sapiens_hsa003300.51878937
96GABAergic synapse_Homo sapiens_hsa047270.51210709
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51176752
98Glutamatergic synapse_Homo sapiens_hsa047240.51139556
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51107612
100Peroxisome_Homo sapiens_hsa041460.50202924
101Asthma_Homo sapiens_hsa053100.49999696
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49946019
103Salivary secretion_Homo sapiens_hsa049700.49082518
104Pyruvate metabolism_Homo sapiens_hsa006200.48328631
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48304798
106N-Glycan biosynthesis_Homo sapiens_hsa005100.47864478
107Hedgehog signaling pathway_Homo sapiens_hsa043400.47650279
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46619256
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45027750
110Herpes simplex infection_Homo sapiens_hsa051680.44621913
111Dorso-ventral axis formation_Homo sapiens_hsa043200.44006709
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43003756
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42115440
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40847846
115Histidine metabolism_Homo sapiens_hsa003400.40540873
116Type I diabetes mellitus_Homo sapiens_hsa049400.40073004
117Systemic lupus erythematosus_Homo sapiens_hsa053220.38239562
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36783275
119Viral carcinogenesis_Homo sapiens_hsa052030.36309981
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33894161
121Legionellosis_Homo sapiens_hsa051340.32929769
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30949572
123Primary immunodeficiency_Homo sapiens_hsa053400.28503555
124HTLV-I infection_Homo sapiens_hsa051660.27315138
125Cardiac muscle contraction_Homo sapiens_hsa042600.26619716
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.25819782
127Shigellosis_Homo sapiens_hsa051310.23799740
128Fatty acid degradation_Homo sapiens_hsa000710.20849141
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.20590364
130Propanoate metabolism_Homo sapiens_hsa006400.19919689
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17945790
132Linoleic acid metabolism_Homo sapiens_hsa005910.17104700
133Sphingolipid metabolism_Homo sapiens_hsa006000.16307103
134Bladder cancer_Homo sapiens_hsa052190.16186010
135Vitamin digestion and absorption_Homo sapiens_hsa049770.14855319
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11930461
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11814554
138beta-Alanine metabolism_Homo sapiens_hsa004100.11257824
139Arachidonic acid metabolism_Homo sapiens_hsa005900.11099167
140Apoptosis_Homo sapiens_hsa042100.09573724
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.09353566
142Circadian rhythm_Homo sapiens_hsa047100.08070966
143Renin-angiotensin system_Homo sapiens_hsa046140.06894452
144Fat digestion and absorption_Homo sapiens_hsa049750.06599344
145Other glycan degradation_Homo sapiens_hsa005110.06000560
146Acute myeloid leukemia_Homo sapiens_hsa052210.03284098
147Arginine biosynthesis_Homo sapiens_hsa002200.03163445

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »