COX17P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1female gonad development (GO:0008585)8.44842988
2regulation of telomere maintenance via telomerase (GO:0032210)8.03060149
3stress granule assembly (GO:0034063)7.18110262
4inner mitochondrial membrane organization (GO:0007007)6.79231333
5central nervous system neuron axonogenesis (GO:0021955)6.75834005
6male meiosis (GO:0007140)6.56734852
7cranial suture morphogenesis (GO:0060363)6.49441857
8negative regulation of telomere maintenance (GO:0032205)6.44702629
9peptidyl-lysine dimethylation (GO:0018027)6.23996726
10regulation of G0 to G1 transition (GO:0070316)6.21701792
11thyroid hormone generation (GO:0006590)6.14071358
12response to hepatocyte growth factor (GO:0035728)5.87816573
13cellular response to hepatocyte growth factor stimulus (GO:0035729)5.87816573
14negative regulation of glycoprotein biosynthetic process (GO:0010561)5.80759150
15centrosome duplication (GO:0051298)5.80282281
16negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.69773613
17lipid translocation (GO:0034204)5.62629355
18phospholipid translocation (GO:0045332)5.62629355
19ventricular trabecula myocardium morphogenesis (GO:0003222)5.49658732
20regulation of protein glycosylation (GO:0060049)5.42719066
21apoptotic DNA fragmentation (GO:0006309)5.31035124
22positive regulation of keratinocyte differentiation (GO:0045618)5.26290659
23viral protein processing (GO:0019082)5.09710791
24DNA strand renaturation (GO:0000733)5.02938568
25thyroid hormone metabolic process (GO:0042403)5.01360550
26intermediate filament cytoskeleton organization (GO:0045104)4.87999954
27regulation of translation, ncRNA-mediated (GO:0045974)4.79319917
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.79319917
29negative regulation of translation, ncRNA-mediated (GO:0040033)4.79319917
30somatic hypermutation of immunoglobulin genes (GO:0016446)4.75355269
31somatic diversification of immune receptors via somatic mutation (GO:0002566)4.75355269
32intermediate filament-based process (GO:0045103)4.73916020
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.66108144
34regulation of natural killer cell mediated immunity (GO:0002715)4.66108144
35heart trabecula morphogenesis (GO:0061384)4.42885479
36negative regulation of glycoprotein metabolic process (GO:1903019)4.41290852
37negative regulation of keratinocyte proliferation (GO:0010839)4.34777790
38maintenance of protein location in nucleus (GO:0051457)4.17712843
39positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.13646131
40negative regulation of fatty acid biosynthetic process (GO:0045717)4.12929847
41regulation of sister chromatid cohesion (GO:0007063)4.11200191
42craniofacial suture morphogenesis (GO:0097094)4.04222767
43mitotic G2 DNA damage checkpoint (GO:0007095)3.98390149
44trabecula morphogenesis (GO:0061383)3.87446366
45regulation of telomere maintenance (GO:0032204)3.85008471
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.81204564
47cellular response to thyroid hormone stimulus (GO:0097067)3.79891023
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79610722
49hydrogen peroxide biosynthetic process (GO:0050665)3.77880588
50galactose metabolic process (GO:0006012)3.77151501
51negative regulation of protein tyrosine kinase activity (GO:0061099)3.66401512
52intracellular protein transmembrane import (GO:0044743)3.60000861
53negative regulation of receptor activity (GO:2000272)3.57466372
54regulation of histone phosphorylation (GO:0033127)3.55461731
55positive regulation of epidermal cell differentiation (GO:0045606)3.54044655
56embryonic heart tube development (GO:0035050)3.53115550
57vitamin transmembrane transport (GO:0035461)3.48375124
58middle ear morphogenesis (GO:0042474)3.46034417
59reactive oxygen species biosynthetic process (GO:1903409)3.43147377
60positive regulation of protein import into nucleus, translocation (GO:0033160)3.42162986
61parturition (GO:0007567)3.39689398
62protein-cofactor linkage (GO:0018065)3.36697839
63regulation of voltage-gated calcium channel activity (GO:1901385)3.36164184
64SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.34977950
65mast cell activation (GO:0045576)3.29234813
66positive regulation of transcription regulatory region DNA binding (GO:2000679)3.28207148
67regulation of membrane lipid distribution (GO:0097035)3.27445859
68natural killer cell activation (GO:0030101)3.23555015
69head development (GO:0060322)3.21861584
70androgen biosynthetic process (GO:0006702)3.21577184
71cell migration involved in heart development (GO:0060973)3.21470871
72outer ear morphogenesis (GO:0042473)3.21138026
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.10927382
74mitotic G2/M transition checkpoint (GO:0044818)3.10891485
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07537997
76ATP synthesis coupled proton transport (GO:0015986)3.07537997
77peptidyl-lysine methylation (GO:0018022)3.04753271
78mRNA transcription from RNA polymerase II promoter (GO:0042789)2.97175868
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96694950
80regulation of interferon-beta biosynthetic process (GO:0045357)2.95136836
81ovulation cycle (GO:0042698)2.88030812
82RNA destabilization (GO:0050779)2.87391506
83regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.85157531
84endocardial cushion morphogenesis (GO:0003203)2.83636444
85virion assembly (GO:0019068)2.79418600
86regulation of keratinocyte proliferation (GO:0010837)2.77602807
87superoxide anion generation (GO:0042554)2.76090707
88negative regulation of cation channel activity (GO:2001258)2.75588086
89histone H3-K4 trimethylation (GO:0080182)2.75386813
90negative regulation of catenin import into nucleus (GO:0035414)2.74961379
91intracellular protein transmembrane transport (GO:0065002)2.73061279
92embryonic hindlimb morphogenesis (GO:0035116)2.72024373
93pyrimidine-containing compound transmembrane transport (GO:0072531)2.70006628
94vitamin transport (GO:0051180)2.67664174
95neurofilament cytoskeleton organization (GO:0060052)18.2071320
96regulation of DNA methylation (GO:0044030)14.0017510
97glyoxylate metabolic process (GO:0046487)11.1593810
98ectoderm development (GO:0007398)10.9664226
99chaperone-mediated protein transport (GO:0072321)10.9176387
100establishment of protein localization to mitochondrial membrane (GO:0090151)10.5391544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.71929022
2IGF1R_20145208_ChIP-Seq_DFB_Human4.37667460
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.21221314
4IRF1_19129219_ChIP-ChIP_H3396_Human4.08383617
5VDR_22108803_ChIP-Seq_LS180_Human3.74917645
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.24520598
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16815749
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.72112392
9EZH2_22144423_ChIP-Seq_EOC_Human2.67962449
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.55900463
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.45732474
12GBX2_23144817_ChIP-Seq_PC3_Human2.31914800
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22247548
14AUTS2_25519132_ChIP-Seq_293T-REX_Human1.99456838
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93968604
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.92247870
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83282398
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83040980
19ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.80559453
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75036772
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70579244
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.66722745
23CBP_20019798_ChIP-Seq_JUKART_Human1.60929218
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60929218
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59410592
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57733639
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55217432
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53188063
29ZNF274_21170338_ChIP-Seq_K562_Hela1.52541694
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50625686
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.50175202
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.49594541
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.49500246
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46808517
35TP53_16413492_ChIP-PET_HCT116_Human1.45732980
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.41814092
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40293718
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40078771
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39836317
40KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38087893
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32310370
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32256347
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.31228661
44LXR_22292898_ChIP-Seq_THP-1_Human1.27895482
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.26803639
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.26264980
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24951644
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.24862856
49VDR_21846776_ChIP-Seq_THP-1_Human1.24312206
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23681165
51REST_21632747_ChIP-Seq_MESCs_Mouse1.19654361
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19292530
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17754825
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.17567917
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17512689
56MYC_22102868_ChIP-Seq_BL_Human1.16757199
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15860330
58CTCF_27219007_Chip-Seq_Bcells_Human1.14654196
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14380313
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13202677
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10160120
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09406727
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04907564
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04395300
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03912509
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.03806079
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03477165
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02165527
69TP53_22573176_ChIP-Seq_HFKS_Human0.99142590
70KLF4_19829295_ChIP-Seq_ESCs_Human0.98512515
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97607364
72NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96810491
73RNF2_27304074_Chip-Seq_NSC_Mouse0.96414321
74AR_21572438_ChIP-Seq_LNCaP_Human0.96334638
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95737247
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95096493
77POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94473478
78MYC_27129775_Chip-Seq_CORNEA_Mouse0.93468886
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.93362227
80EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93198133
81RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93198133
82GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.92496460
83NANOG_20526341_ChIP-Seq_ESCs_Human0.92170133
84RARB_27405468_Chip-Seq_BRAIN_Mouse0.88646341
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88223217
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.87675261
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87670713
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87340173
89KDM2B_26808549_Chip-Seq_K562_Human0.86488926
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.85712660
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84599832
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83349746
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.82577338
94KDM2B_26808549_Chip-Seq_REH_Human0.79431025
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79397273
96CBP_21632823_ChIP-Seq_H3396_Human0.77884908
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77545168
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75679817
99NCOR_22424771_ChIP-Seq_293T_Human0.74381453
100AR_25329375_ChIP-Seq_VCAP_Human0.74316530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003786_premature_aging4.72525975
2MP0002653_abnormal_ependyma_morphology4.37838051
3MP0002876_abnormal_thyroid_physiology4.36982110
4MP0004264_abnormal_extraembryonic_tissu3.32206593
5MP0003763_abnormal_thymus_physiology2.74722242
6MP0004885_abnormal_endolymph2.72964705
7MP0001986_abnormal_taste_sensitivity2.71026603
8MP0006082_CNS_inflammation2.45655657
9MP0005671_abnormal_response_to2.28658015
10MP0006276_abnormal_autonomic_nervous2.25967435
11MP0008995_early_reproductive_senescence11.9751677
12MP0008875_abnormal_xenobiotic_pharmacok1.98028850
13MP0004742_abnormal_vestibular_system1.93990328
14MP0000566_synostosis1.78126188
15MP0002132_abnormal_respiratory_system1.74905423
16MP0001849_ear_inflammation1.67673606
17MP0004270_analgesia1.67356448
18MP0010094_abnormal_chromosome_stability1.66190314
19MP0002697_abnormal_eye_size1.58458878
20MP0009333_abnormal_splenocyte_physiolog1.37481621
21MP0002127_abnormal_cardiovascular_syste1.37301529
22MP0001542_abnormal_bone_strength1.33240968
23MP0001119_abnormal_female_reproductive1.31543351
24MP0009046_muscle_twitch1.28995972
25MP0003879_abnormal_hair_cell1.24011051
26MP0005423_abnormal_somatic_nervous1.20510578
27MP0001440_abnormal_grooming_behavior1.15196864
28MP0003880_abnormal_central_pattern1.14052945
29MP0001485_abnormal_pinna_reflex1.11766031
30MP0009379_abnormal_foot_pigmentation1.08261652
31MP0003699_abnormal_female_reproductive1.07861312
32MP0003111_abnormal_nucleus_morphology1.06198879
33MP0000778_abnormal_nervous_system1.03416476
34MP0003936_abnormal_reproductive_system0.99837189
35MP0002735_abnormal_chemical_nociception0.99174882
36MP0004019_abnormal_vitamin_homeostasis0.98897944
37MP0001666_abnormal_nutrient_absorption0.98127557
38MP0005084_abnormal_gallbladder_morpholo0.93239252
39MP0006072_abnormal_retinal_apoptosis0.93105056
40MP0001881_abnormal_mammary_gland0.89280981
41MP0000955_abnormal_spinal_cord0.85791444
42MP0001790_abnormal_immune_system0.84806253
43MP0005387_immune_system_phenotype0.84806253
44MP0002734_abnormal_mechanical_nocicepti0.83985168
45MP0001905_abnormal_dopamine_level0.82680702
46MP0009745_abnormal_behavioral_response0.82478630
47MP0004859_abnormal_synaptic_plasticity0.82279812
48MP0002398_abnormal_bone_marrow0.81942283
49MP0005085_abnormal_gallbladder_physiolo0.79612735
50MP0002210_abnormal_sex_determination0.78833768
51MP0005025_abnormal_response_to0.78672208
52MP0002723_abnormal_immune_serum0.77835056
53MP0002837_dystrophic_cardiac_calcinosis0.76108105
54MP0002420_abnormal_adaptive_immunity0.74234000
55MP0003787_abnormal_imprinting0.73352831
56MP0008877_abnormal_DNA_methylation0.72433382
57MP0002067_abnormal_sensory_capabilities0.72411381
58MP0005508_abnormal_skeleton_morphology0.72247697
59MP0002184_abnormal_innervation0.71422877
60MP0001944_abnormal_pancreas_morphology0.71081661
61MP0000716_abnormal_immune_system0.71038258
62MP0004142_abnormal_muscle_tone0.70426301
63MP0000049_abnormal_middle_ear0.68703697
64MP0001819_abnormal_immune_cell0.68612346
65MP0004130_abnormal_muscle_cell0.66708154
66MP0000569_abnormal_digit_pigmentation0.65199364
67MP0000026_abnormal_inner_ear0.63718227
68MP0002234_abnormal_pharynx_morphology0.63010922
69MP0002429_abnormal_blood_cell0.62720788
70MP0002116_abnormal_craniofacial_bone0.61101596
71MP0001286_abnormal_eye_development0.61030600
72MP0002557_abnormal_social/conspecific_i0.60193372
73MP0003123_paternal_imprinting0.59491244
74MP0000920_abnormal_myelination0.59443868
75MP0003635_abnormal_synaptic_transmissio0.58547546
76MP0000343_altered_response_to0.57791459
77MP0008775_abnormal_heart_ventricle0.57636971
78MP0003866_abnormal_defecation0.55955428
79MP0009785_altered_susceptibility_to0.55667229
80MP0002752_abnormal_somatic_nervous0.55290343
81MP0002064_seizures0.54973660
82MP0003011_delayed_dark_adaptation0.53520268
83MP0002736_abnormal_nociception_after0.52476359
84MP0004145_abnormal_muscle_electrophysio0.52391813
85MP0002161_abnormal_fertility/fecundity0.52165368
86MP0001800_abnormal_humoral_immune0.51791971
87MP0001963_abnormal_hearing_physiology0.51245326
88MP0005000_abnormal_immune_tolerance0.51144070
89MP0002163_abnormal_gland_morphology0.50473815
90MP0001661_extended_life_span0.50003334
91MP0002272_abnormal_nervous_system0.49345203
92MP0003632_abnormal_nervous_system0.48703947
93MP0002882_abnormal_neuron_morphology0.48103082
94MP0000627_abnormal_mammary_gland0.46898708
95MP0003698_abnormal_male_reproductive0.45817506
96MP0001145_abnormal_male_reproductive0.45143050
97MP0003195_calcinosis0.44306823
98MP0003646_muscle_fatigue0.44151614
99MP0006292_abnormal_olfactory_placode0.42471931
100MP0005464_abnormal_platelet_physiology0.40541420

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)9.80150041
2Reticulocytopenia (HP:0001896)9.22705687
3Abnormality of the renal collecting system (HP:0004742)9.16064324
4Chromsome breakage (HP:0040012)8.61796234
5Abnormality of pyrimidine metabolism (HP:0004353)8.13481715
6Abnormality of DNA repair (HP:0003254)6.93447638
7Oral leukoplakia (HP:0002745)6.54796060
8Ureteral duplication (HP:0000073)6.33995044
9Aplastic anemia (HP:0001915)6.11843496
10Duplication of thumb phalanx (HP:0009942)5.80279336
11Ectopic kidney (HP:0000086)5.25771416
12Increased serum pyruvate (HP:0003542)4.88263652
13Absent thumb (HP:0009777)4.61383423
14Autoimmune thrombocytopenia (HP:0001973)4.19515357
15Aplasia/Hypoplasia of the uvula (HP:0010293)4.09483640
16Abnormality of glycolysis (HP:0004366)4.08425463
17Enlarged epiphyses (HP:0010580)4.01998163
18Thyroid-stimulating hormone excess (HP:0002925)3.88032621
19Meckel diverticulum (HP:0002245)3.60371981
20Absent radius (HP:0003974)3.56510629
21Eosinophilia (HP:0001880)3.54183729
22Abnormality of the preputium (HP:0100587)3.49803092
23Abnormality of the ileum (HP:0001549)3.45128931
24Aplasia involving forearm bones (HP:0009822)3.40109351
25Absent forearm bone (HP:0003953)3.40109351
26Horseshoe kidney (HP:0000085)3.39849222
27Pancytopenia (HP:0001876)3.36310350
28Abnormality of B cell number (HP:0010975)3.32616402
29Abnormality of T cell number (HP:0011839)3.23982224
30Autoimmune hemolytic anemia (HP:0001890)3.18892606
31Stomach cancer (HP:0012126)3.08446373
32Hypergonadotropic hypogonadism (HP:0000815)3.01733983
33Renal cortical cysts (HP:0000803)3.01231686
34Flattened epiphyses (HP:0003071)3.00106294
35Clubbing of toes (HP:0100760)2.91510649
36Rough bone trabeculation (HP:0100670)2.90794865
37Increased IgM level (HP:0003496)2.82681658
38Abnormality of chromosome stability (HP:0003220)2.77486351
39Granulocytopenia (HP:0001913)2.75402294
40Hypoplasia of the capital femoral epiphysis (HP:0003090)2.70180444
41Abnormality of eosinophils (HP:0001879)2.68482477
42Abnormality of the carotid arteries (HP:0005344)2.66522627
43Abnormality of reticulocytes (HP:0004312)2.59861163
44Abnormality of the vertebral endplates (HP:0005106)2.57827832
45Abnormality of nucleobase metabolism (HP:0010932)2.51967492
46Joint swelling (HP:0001386)2.50569806
47Increased hepatocellular lipid droplets (HP:0006565)2.41928189
48Short thumb (HP:0009778)2.40629817
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40443193
50Leukopenia (HP:0001882)2.31939335
51Abnormality of T cells (HP:0002843)2.27868973
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.27751972
53Partial duplication of the phalanx of hand (HP:0009999)2.27437182
54Cellular immunodeficiency (HP:0005374)2.27288590
55Bone marrow hypocellularity (HP:0005528)2.27033103
56Abnormality of the epiphysis of the femoral head (HP:0010574)2.26176133
57Absent epiphyses (HP:0010577)2.24486857
58Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24486857
59Neutropenia (HP:0001875)2.23444108
60Small intestinal stenosis (HP:0012848)2.18283021
61Duodenal stenosis (HP:0100867)2.18283021
62Renal Fanconi syndrome (HP:0001994)2.16428224
63Abnormal trabecular bone morphology (HP:0100671)2.15702653
64Coronal craniosynostosis (HP:0004440)2.13433829
65Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.07903578
66Abnormality of femoral epiphyses (HP:0006499)2.07903578
67Megalocornea (HP:0000485)2.06955481
68Syringomyelia (HP:0003396)2.05875114
69Spinal cord lesions (HP:0100561)2.05875114
70Abnormality of the femoral head (HP:0003368)2.04533201
71Renal agenesis (HP:0000104)2.03821540
72Lipid accumulation in hepatocytes (HP:0006561)2.01425955
73Duplicated collecting system (HP:0000081)10.2203033
74Hypochromic anemia (HP:0001931)1.98185452
75Turricephaly (HP:0000262)1.95767470
76Pallor (HP:0000980)1.87403176
77Tracheoesophageal fistula (HP:0002575)1.87109438
78Abnormality of the duodenum (HP:0002246)1.81736607
79Triphalangeal thumb (HP:0001199)1.80363194
80Disproportionate short-trunk short stature (HP:0003521)1.76578059
81Trigonocephaly (HP:0000243)1.74295381
82T lymphocytopenia (HP:0005403)1.74133340
83Leukocytosis (HP:0001974)1.65643757
84Waddling gait (HP:0002515)1.65213744
85Mutism (HP:0002300)1.64691970
86Premature graying of hair (HP:0002216)1.63395739
87Truncal obesity (HP:0001956)1.59487916
88Abnormality of cells of the lymphoid lineage (HP:0012140)1.57829469
89Abnormality of the 2nd finger (HP:0004100)1.57614678
90Thoracic kyphosis (HP:0002942)1.55690982
91Exertional dyspnea (HP:0002875)1.55324672
92Abnormality of the phalanges of the hallux (HP:0010057)1.54956530
93Abnormality of the parietal bone (HP:0002696)1.53530680
94Anomalous pulmonary venous return (HP:0010772)1.53026893
95Fetal akinesia sequence (HP:0001989)1.52469319
96Progressive neurologic deterioration (HP:0002344)1.51826783
97Abnormality of the renal cortex (HP:0011035)1.47201552
98Abnormality of cochlea (HP:0000375)1.45909558
99Fine hair (HP:0002213)1.44377131
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.44003338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.28801909
2TXK7.26847544
3BCKDK3.58591331
4TAOK312.4762092
5ZAP701.76723637
6TESK21.61406708
7PRPF4B1.49737078
8CAMK1D1.37705901
9IKBKE0.89497513
10CAMK1G0.89074177
11SGK10.82594008
12MUSK0.80921893
13EPHB20.80570641
14TESK10.79085413
15BMPR1B0.68208253
16TYRO30.67689315
17PIK3CA0.67568550
18LIMK10.64700374
19TBK10.59941146
20NLK0.57957747
21MAPK130.55115566
22DYRK1B0.54580915
23SYK0.54164877
24ITK0.49632768
25WNK30.48413546
26SGK20.47443831
27LCK0.46294958
28ATR0.44123059
29JAK10.43099370
30SGK4940.37999236
31SGK2230.37999236
32LYN0.35999569
33HCK0.34739711
34NTRK20.32300705
35MAPK120.29453408
36DYRK1A0.29126988
37PRKAA10.29029775
38NTRK10.27809679
39MAP4K20.26618849
40ADRBK20.26516280
41MINK10.24577047
42INSRR0.24033629
43OBSCN0.23783759
44PRKAA20.23573035
45IGF1R0.23432355
46CAMK10.23041025
47CSNK1G10.22798481
48GRK10.22719302
49FYN0.22442114
50PINK10.22330465
51CSNK1A10.22258946
52PRKCQ0.21714822
53GSK3A0.20941944
54OXSR10.19980227
55PRKCG0.19850310
56AKT10.19572830
57IKBKB0.17718998
58ERBB20.16954322
59MARK10.16822184
60MAP3K40.16207847
61MAP2K70.16132309
62SGK30.16109390
63DAPK30.15639837
64WNK40.14575740
65INSR0.14244808
66MAPK30.13578919
67RPS6KA10.13112388
68AKT20.12524221
69TIE10.12270865
70DYRK20.11963725
71MTOR0.10796530
72GRK70.10310466
73CASK0.10261071
74CDK140.09656426
75PIM10.09128786
76MAPK150.08858637
77PRKACA0.08514615
78BTK0.08110303
79FRK0.08053771
80MAPK80.07899512
81PRKCA0.07689068
82CSNK1E0.07496321
83MAPK140.07195317
84ADRBK10.06371630
85MAPKAPK20.06144694
86ATM0.05808941
87PRKCE0.05742872
88RPS6KA30.04442785
89PAK30.04321854
90TNK20.03853141
91PRKCB0.03784186
92CDK150.03782520
93PTK60.03513200
94ERBB30.03305513
95PIM20.03127326
96MAP3K50.03055083
97CAMK2A0.02851995
98CDK50.02761524
99ICK0.02337476
100AKT30.02291572

Predicted pathways (KEGG)

RankGene SetZ-score
1Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006306.13229520
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.16608884
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.00275636
4Fanconi anemia pathway_Homo sapiens_hsa034602.54460076
5Pyruvate metabolism_Homo sapiens_hsa006202.50650380
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.42021575
7Oxidative phosphorylation_Homo sapiens_hsa001902.31407141
8Graft-versus-host disease_Homo sapiens_hsa053322.27394347
9Allograft rejection_Homo sapiens_hsa053302.27169727
10Autoimmune thyroid disease_Homo sapiens_hsa053202.25746105
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.16314250
12Galactose metabolism_Homo sapiens_hsa000522.01117457
13Type I diabetes mellitus_Homo sapiens_hsa049401.88259998
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.79337971
15Cardiac muscle contraction_Homo sapiens_hsa042601.74453761
16Ribosome_Homo sapiens_hsa030101.71229999
17Parkinsons disease_Homo sapiens_hsa050121.71096440
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69823795
19Linoleic acid metabolism_Homo sapiens_hsa005911.64510374
20Asthma_Homo sapiens_hsa053101.58108423
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50289819
22Ether lipid metabolism_Homo sapiens_hsa005651.50033532
23Basal transcription factors_Homo sapiens_hsa030221.37328866
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34051749
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30005143
26Mismatch repair_Homo sapiens_hsa034301.29832077
27Vitamin digestion and absorption_Homo sapiens_hsa049771.26317993
28Hematopoietic cell lineage_Homo sapiens_hsa046401.24621475
29Staphylococcus aureus infection_Homo sapiens_hsa051501.22412415
30Malaria_Homo sapiens_hsa051441.18144226
31T cell receptor signaling pathway_Homo sapiens_hsa046601.17178505
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16890401
33Pancreatic secretion_Homo sapiens_hsa049721.16555074
34Propanoate metabolism_Homo sapiens_hsa006401.12653814
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.11127500
36Viral myocarditis_Homo sapiens_hsa054161.08266129
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08019623
38Alzheimers disease_Homo sapiens_hsa050101.06955988
39Glutamatergic synapse_Homo sapiens_hsa047241.05694214
40Salivary secretion_Homo sapiens_hsa049701.05328412
41Butanoate metabolism_Homo sapiens_hsa006500.98581312
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97808461
43Morphine addiction_Homo sapiens_hsa050320.97116158
44Bile secretion_Homo sapiens_hsa049760.92179100
45Ovarian steroidogenesis_Homo sapiens_hsa049130.90970148
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.86596962
47Nicotine addiction_Homo sapiens_hsa050330.86482352
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85170431
49Protein digestion and absorption_Homo sapiens_hsa049740.83644266
50Protein export_Homo sapiens_hsa030600.82915900
51Synaptic vesicle cycle_Homo sapiens_hsa047210.72660842
52Rheumatoid arthritis_Homo sapiens_hsa053230.70752711
53Huntingtons disease_Homo sapiens_hsa050160.70556615
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68414043
55Phototransduction_Homo sapiens_hsa047440.66116641
56Olfactory transduction_Homo sapiens_hsa047400.63798105
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63473624
58Circadian entrainment_Homo sapiens_hsa047130.62192106
59Serotonergic synapse_Homo sapiens_hsa047260.61989471
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61495354
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61068931
62Vitamin B6 metabolism_Homo sapiens_hsa007500.60823039
63Platelet activation_Homo sapiens_hsa046110.60804465
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59024299
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58413406
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57405872
67Insulin secretion_Homo sapiens_hsa049110.57043511
68Fatty acid biosynthesis_Homo sapiens_hsa000610.56375717
69Gastric acid secretion_Homo sapiens_hsa049710.56321808
70Arachidonic acid metabolism_Homo sapiens_hsa005900.55402321
71Endocytosis_Homo sapiens_hsa041440.55157418
72GABAergic synapse_Homo sapiens_hsa047270.53030054
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50398227
74Primary immunodeficiency_Homo sapiens_hsa053400.50333577
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49921078
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49644635
77Caffeine metabolism_Homo sapiens_hsa002320.48084143
78Thyroid hormone synthesis_Homo sapiens_hsa049180.47793821
79cAMP signaling pathway_Homo sapiens_hsa040240.47153967
80Pertussis_Homo sapiens_hsa051330.45095958
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43604880
82Systemic lupus erythematosus_Homo sapiens_hsa053220.42182135
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.42064563
84Phagosome_Homo sapiens_hsa041450.41544136
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39750279
86Mineral absorption_Homo sapiens_hsa049780.37475954
87Retinol metabolism_Homo sapiens_hsa008300.36541408
88MAPK signaling pathway_Homo sapiens_hsa040100.35409079
89Dopaminergic synapse_Homo sapiens_hsa047280.32701568
90Taste transduction_Homo sapiens_hsa047420.31022030
91Antigen processing and presentation_Homo sapiens_hsa046120.30497889
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29629511
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27873628
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.26926210
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24847310
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24174858
97Dilated cardiomyopathy_Homo sapiens_hsa054140.23024251
98Cholinergic synapse_Homo sapiens_hsa047250.22810431
99Chemical carcinogenesis_Homo sapiens_hsa052040.22762042
100Rap1 signaling pathway_Homo sapiens_hsa040150.22167390

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