COX14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.57813950
2ATP synthesis coupled proton transport (GO:0015986)8.14597086
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.14597086
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.10773307
5respiratory electron transport chain (GO:0022904)7.32078449
6electron transport chain (GO:0022900)7.16878119
7ribosomal small subunit assembly (GO:0000028)5.82577923
8protein neddylation (GO:0045116)5.77941654
9chaperone-mediated protein transport (GO:0072321)5.42350818
10* protein complex biogenesis (GO:0070271)5.27862397
11ribosomal small subunit biogenesis (GO:0042274)5.21455422
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.21209038
13NADH dehydrogenase complex assembly (GO:0010257)5.21209038
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.21209038
15viral transcription (GO:0019083)5.04003487
16translational termination (GO:0006415)4.82567921
17oxidative phosphorylation (GO:0006119)4.81631578
18* mitochondrial respiratory chain complex assembly (GO:0033108)4.75938785
19protein targeting to ER (GO:0045047)4.75130246
20cotranslational protein targeting to membrane (GO:0006613)4.70407859
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.68582225
22protein localization to endoplasmic reticulum (GO:0070972)4.58232974
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.51697732
24hydrogen ion transmembrane transport (GO:1902600)4.47845353
25ATP biosynthetic process (GO:0006754)4.40546464
26inner mitochondrial membrane organization (GO:0007007)4.38866154
27purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.32749722
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.29541830
29purine nucleoside triphosphate biosynthetic process (GO:0009145)4.22845938
30regulation of mitochondrial translation (GO:0070129)4.15024612
31proteasome assembly (GO:0043248)4.08344305
32GTP biosynthetic process (GO:0006183)4.05461126
33translational elongation (GO:0006414)4.04848076
34proton transport (GO:0015992)3.98431317
35viral life cycle (GO:0019058)3.97842399
36DNA deamination (GO:0045006)3.90922609
37hydrogen transport (GO:0006818)3.88480791
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.85297583
39termination of RNA polymerase III transcription (GO:0006386)3.85297583
40cellular protein complex disassembly (GO:0043624)3.83193507
41ribonucleoside triphosphate biosynthetic process (GO:0009201)3.80525392
42* respiratory chain complex IV assembly (GO:0008535)3.76472176
43water-soluble vitamin biosynthetic process (GO:0042364)3.74870711
44iron-sulfur cluster assembly (GO:0016226)3.74845058
45metallo-sulfur cluster assembly (GO:0031163)3.74845058
46maturation of SSU-rRNA (GO:0030490)3.73917144
47* cytochrome complex assembly (GO:0017004)3.64851021
48protein targeting to mitochondrion (GO:0006626)3.61210728
49translation (GO:0006412)3.60155359
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57711101
51establishment of protein localization to mitochondrion (GO:0072655)3.48878410
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46814678
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46814678
54guanosine-containing compound biosynthetic process (GO:1901070)3.42853878
55aerobic respiration (GO:0009060)3.42758605
56regulation of oxidative phosphorylation (GO:0002082)3.40241712
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.34356995
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33316242
59nucleoside triphosphate biosynthetic process (GO:0009142)3.32306939
60peptidyl-histidine modification (GO:0018202)3.29535530
61translational initiation (GO:0006413)3.28888645
62protein localization to mitochondrion (GO:0070585)3.26661625
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25953770
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.25953770
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25484769
66purine nucleotide salvage (GO:0032261)3.25116035
67UTP biosynthetic process (GO:0006228)3.22368048
68positive regulation of mitochondrial fission (GO:0090141)3.22076626
69intracellular protein transmembrane import (GO:0044743)3.21868933
70regulation of cellular amino acid metabolic process (GO:0006521)3.21484225
71protein targeting to membrane (GO:0006612)3.19513473
72signal transduction involved in cell cycle checkpoint (GO:0072395)3.19278859
73dopamine transport (GO:0015872)3.17122601
74cullin deneddylation (GO:0010388)3.14862610
75pseudouridine synthesis (GO:0001522)3.14540695
76mitochondrial transport (GO:0006839)3.10550861
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.09471796
78purine nucleoside monophosphate biosynthetic process (GO:0009127)3.08573337
79purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.08573337
80rRNA modification (GO:0000154)3.08554554
81protein complex disassembly (GO:0043241)3.08417088
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07921930
83negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.06672564
84ribosomal large subunit biogenesis (GO:0042273)3.05631031
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04814505
86platelet dense granule organization (GO:0060155)3.03847981
87protein-cofactor linkage (GO:0018065)3.03476111
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02531818
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99870431
90protein maturation by protein folding (GO:0022417)2.99747788
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99274305
92macromolecular complex disassembly (GO:0032984)2.99130991
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98567651
94regulation of cellular amine metabolic process (GO:0033238)2.97955580
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95806384
96regulation of autophagic vacuole assembly (GO:2000785)2.95518451
97protein deneddylation (GO:0000338)2.94236908
98CTP metabolic process (GO:0046036)2.93979007
99CTP biosynthetic process (GO:0006241)2.93979007
100positive regulation of ligase activity (GO:0051351)2.91897698
101deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.90920418
102quinone biosynthetic process (GO:1901663)2.88255101
103ubiquinone biosynthetic process (GO:0006744)2.88255101
104purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88156598
105GDP-mannose metabolic process (GO:0019673)2.87357522
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86023434
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83003387
108* cellular component biogenesis (GO:0044085)2.82300008
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79578198
110negative regulation of ligase activity (GO:0051352)2.79578198
111GPI anchor biosynthetic process (GO:0006506)2.79458489
112ATP hydrolysis coupled proton transport (GO:0015991)2.77411235
113energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.77411235
1147-methylguanosine mRNA capping (GO:0006370)2.76479033
115mannosylation (GO:0097502)2.75323504
116UTP metabolic process (GO:0046051)2.74678580
117regulation of cellular respiration (GO:0043457)2.74578456
1187-methylguanosine RNA capping (GO:0009452)2.74318876
119RNA capping (GO:0036260)2.74318876
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74049596
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74049596
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73733256
123signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73733256
124signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73733256
125nucleoside diphosphate phosphorylation (GO:0006165)2.73545116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.08494758
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.23754613
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15524653
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.88006359
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82811670
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.80003750
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.71011791
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.67230027
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.52582689
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.43058061
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.28552002
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.27720071
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.73413452
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70777176
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54117340
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53244795
17CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.52840403
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.46597442
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30794047
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23005949
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.20231508
22VDR_23849224_ChIP-Seq_CD4+_Human2.17727713
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16077815
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13773192
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.09222602
26EZH2_22144423_ChIP-Seq_EOC_Human1.98660204
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.90315253
28DCP1A_22483619_ChIP-Seq_HELA_Human1.85432613
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73719803
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72823546
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70514042
32VDR_22108803_ChIP-Seq_LS180_Human1.67685764
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67418093
34FOXP3_21729870_ChIP-Seq_TREG_Human1.65037536
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63211310
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.61188005
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.58323745
38XRN2_22483619_ChIP-Seq_HELA_Human1.57767649
39ELK1_19687146_ChIP-ChIP_HELA_Human1.56602927
40CTCF_18555785_ChIP-Seq_MESCs_Mouse1.55666261
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51977335
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47224935
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45781421
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45029526
45TTF2_22483619_ChIP-Seq_HELA_Human1.44967933
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43087852
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43062177
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40992665
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36710689
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35302267
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34108053
52GABP_19822575_ChIP-Seq_HepG2_Human1.32592395
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24410701
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23645879
55TP53_22573176_ChIP-Seq_HFKS_Human1.23133912
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22306675
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21989868
58IGF1R_20145208_ChIP-Seq_DFB_Human1.19984449
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16366711
60IRF1_19129219_ChIP-ChIP_H3396_Human1.15572787
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10647465
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10512713
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.09327812
64TAF15_26573619_Chip-Seq_HEK293_Human1.08520401
65ZNF274_21170338_ChIP-Seq_K562_Hela1.07145324
66MYC_18940864_ChIP-ChIP_HL60_Human1.05648733
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.05286541
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03433084
69AR_20517297_ChIP-Seq_VCAP_Human1.03248367
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03020366
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.03020366
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98948756
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98429497
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98137837
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96895877
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95411257
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94722327
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93539079
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92994767
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92349938
81KDM5A_27292631_Chip-Seq_BREAST_Human0.91879528
82JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91322789
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91145113
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90015409
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89974026
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89793238
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89077399
88EZH2_27304074_Chip-Seq_ESCs_Mouse0.88434263
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88304708
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86565018
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86160752
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86131088
93GBX2_23144817_ChIP-Seq_PC3_Human0.86114974
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86048922
95NANOG_20526341_ChIP-Seq_ESCs_Human0.85459697
96STAT1_20625510_ChIP-Seq_HELA_Human0.85454108
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.83502109
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83259470
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82732098
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82227080
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81393134
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80938899
103NANOG_19829295_ChIP-Seq_ESCs_Human0.80545817
104SOX2_19829295_ChIP-Seq_ESCs_Human0.80545817
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.79510986
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79005587
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.78943105
108GATA3_21878914_ChIP-Seq_MCF-7_Human0.78591928
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78473350
110NCOR_22424771_ChIP-Seq_293T_Human0.78444702
111ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77210136
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77177845
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.76907626
114JARID2_20075857_ChIP-Seq_MESCs_Mouse0.75861389
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.75488627
116ELF5_23300383_ChIP-Seq_T47D_Human0.75446039
117TFEB_21752829_ChIP-Seq_HELA_Human0.74901979
118TAF2_19829295_ChIP-Seq_ESCs_Human0.74816954
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74256996
120FOXP1_21924763_ChIP-Seq_HESCs_Human0.73932484
121MYC_19829295_ChIP-Seq_ESCs_Human0.73870536
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73649703
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73502742
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72826555
125ERG_20517297_ChIP-Seq_VCAP_Human0.72377435
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.72048081
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70831452
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70669347
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.70627465
130NOTCH1_21737748_ChIP-Seq_TLL_Human0.69869192
131HTT_18923047_ChIP-ChIP_STHdh_Human0.69855898
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.69689365
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69655267
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69447087
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69024276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.56400008
2MP0003806_abnormal_nucleotide_metabolis4.09407815
3MP0003880_abnormal_central_pattern3.70959128
4MP0001529_abnormal_vocalization3.26186524
5MP0002837_dystrophic_cardiac_calcinosis3.12073110
6MP0001905_abnormal_dopamine_level2.75279549
7MP0003011_delayed_dark_adaptation2.71936041
8MP0006036_abnormal_mitochondrial_physio2.69833112
9MP0001986_abnormal_taste_sensitivity2.61027656
10MP0006276_abnormal_autonomic_nervous2.50743344
11MP0008875_abnormal_xenobiotic_pharmacok2.32313214
12MP0002736_abnormal_nociception_after2.12832445
13MP0000372_irregular_coat_pigmentation1.97267783
14MP0001188_hyperpigmentation1.95700559
15MP0002638_abnormal_pupillary_reflex1.94003810
16MP0004142_abnormal_muscle_tone1.92840393
17MP0003195_calcinosis1.88272962
18MP0006035_abnormal_mitochondrial_morpho1.87993767
19MP0002735_abnormal_chemical_nociception1.85156940
20MP0001968_abnormal_touch/_nociception1.85045123
21MP0002272_abnormal_nervous_system1.82782486
22MP0002163_abnormal_gland_morphology1.81269786
23MP0002277_abnormal_respiratory_mucosa1.80025905
24MP0010386_abnormal_urinary_bladder1.74710939
25MP0003646_muscle_fatigue1.74703420
26MP0003186_abnormal_redox_activity1.74309822
27MP0002139_abnormal_hepatobiliary_system1.66026683
28MP0005379_endocrine/exocrine_gland_phen1.65648334
29MP0005332_abnormal_amino_acid1.65344154
30MP0000749_muscle_degeneration1.63764805
31MP0002876_abnormal_thyroid_physiology1.62948501
32MP0004147_increased_porphyrin_level1.61694288
33MP0009745_abnormal_behavioral_response1.61432540
34MP0003786_premature_aging1.59766200
35MP0001984_abnormal_olfaction1.54076256
36MP0003136_yellow_coat_color1.53018310
37MP0001501_abnormal_sleep_pattern1.52697369
38MP0002734_abnormal_mechanical_nocicepti1.52687387
39MP0005408_hypopigmentation1.50601593
40MP0005670_abnormal_white_adipose1.50205355
41MP0002148_abnormal_hypersensitivity_rea1.47997308
42MP0002064_seizures1.45999750
43MP0005365_abnormal_bile_salt1.43859287
44MP0001970_abnormal_pain_threshold1.42618524
45MP0005084_abnormal_gallbladder_morpholo1.41928029
46MP0008058_abnormal_DNA_repair1.41763824
47MP0000751_myopathy1.39191573
48MP0002693_abnormal_pancreas_physiology1.38853354
49MP0004215_abnormal_myocardial_fiber1.38497391
50MP0003315_abnormal_perineum_morphology1.37758507
51MP0002822_catalepsy1.37603892
52MP0005551_abnormal_eye_electrophysiolog1.37032326
53MP0004145_abnormal_muscle_electrophysio1.32857463
54MP0004043_abnormal_pH_regulation1.31209613
55MP0005409_darkened_coat_color1.28400825
56MP0004019_abnormal_vitamin_homeostasis1.28338106
57MP0005423_abnormal_somatic_nervous1.27303858
58MP0004036_abnormal_muscle_relaxation1.26857436
59MP0005645_abnormal_hypothalamus_physiol1.26686195
60MP0009046_muscle_twitch1.26067114
61MP0004270_analgesia1.26016003
62MP0001756_abnormal_urination1.23173275
63MP0001440_abnormal_grooming_behavior1.22899005
64MP0002733_abnormal_thermal_nociception1.22523154
65MP0001664_abnormal_digestion1.22057790
66MP0002132_abnormal_respiratory_system1.20134782
67MP0002572_abnormal_emotion/affect_behav1.18933488
68MP0002909_abnormal_adrenal_gland1.18062619
69MP0003635_abnormal_synaptic_transmissio1.18052375
70MP0005171_absent_coat_pigmentation1.18008288
71MP0003718_maternal_effect1.16072732
72MP0005636_abnormal_mineral_homeostasis1.14423945
73MP0005646_abnormal_pituitary_gland1.13857989
74MP0005253_abnormal_eye_physiology1.11831374
75MP0001485_abnormal_pinna_reflex1.11079771
76MP0010329_abnormal_lipoprotein_level1.10900082
77MP0001486_abnormal_startle_reflex1.08940295
78MP0005389_reproductive_system_phenotype1.08198034
79MP0002160_abnormal_reproductive_system1.07526525
80MP0003724_increased_susceptibility_to1.07061458
81MP0001944_abnormal_pancreas_morphology1.05498674
82MP0008995_early_reproductive_senescence1.05103972
83MP0009785_altered_susceptibility_to1.04993841
84MP0005386_behavior/neurological_phenoty1.04136492
85MP0004924_abnormal_behavior1.04136492
86MP0005410_abnormal_fertilization1.03624683
87MP0005075_abnormal_melanosome_morpholog1.03222000
88MP0002067_abnormal_sensory_capabilities1.02729368
89MP0001835_abnormal_antigen_presentation1.02224660
90MP0003137_abnormal_impulse_conducting1.01164740
91MP0009643_abnormal_urine_homeostasis0.99396740
92MP0006292_abnormal_olfactory_placode0.99274818
93MP0002751_abnormal_autonomic_nervous0.97683418
94MP0003879_abnormal_hair_cell0.96949880
95MP0005266_abnormal_metabolism0.95204081
96MP0001853_heart_inflammation0.94318121
97MP0006072_abnormal_retinal_apoptosis0.92553162
98MP0001661_extended_life_span0.91282313
99MP0000013_abnormal_adipose_tissue0.91213265
100MP0008004_abnormal_stomach_pH0.91078575
101MP0005085_abnormal_gallbladder_physiolo0.90783310
102MP0002234_abnormal_pharynx_morphology0.90727708
103MP0004484_altered_response_of0.90659264
104MP0002090_abnormal_vision0.89533907
105MP0003123_paternal_imprinting0.89167819
106MP0005319_abnormal_enzyme/_coenzyme0.88695234
107MP0000343_altered_response_to0.88604252
108MP0003866_abnormal_defecation0.87643380
109MP0000358_abnormal_cell_content/0.87343773
110MP0001727_abnormal_embryo_implantation0.87282946
111MP0000920_abnormal_myelination0.86768697
112MP0002078_abnormal_glucose_homeostasis0.86034473
113MP0002063_abnormal_learning/memory/cond0.85993252
114MP0008569_lethality_at_weaning0.85298294
115MP0001919_abnormal_reproductive_system0.85195128
116MP0005330_cardiomyopathy0.85007111
117MP0005584_abnormal_enzyme/coenzyme_acti0.84204836
118MP0001764_abnormal_homeostasis0.83611389
119MP0004381_abnormal_hair_follicle0.83609386
120MP0000681_abnormal_thyroid_gland0.83318870
121MP0003787_abnormal_imprinting0.82675008
122MP0008877_abnormal_DNA_methylation0.82638677
123MP0002102_abnormal_ear_morphology0.82118489
124MP0005535_abnormal_body_temperature0.81383925
125MP0008872_abnormal_physiological_respon0.81018703
126MP0000538_abnormal_urinary_bladder0.79618558
127MP0005448_abnormal_energy_balance0.79563576
128MP0004084_abnormal_cardiac_muscle0.79467205
129MP0005174_abnormal_tail_pigmentation0.79131545
130MP0001963_abnormal_hearing_physiology0.78253802
131MP0000230_abnormal_systemic_arterial0.77983139
132MP0009333_abnormal_splenocyte_physiolog0.77500550
133MP0001765_abnormal_ion_homeostasis0.77492481
134MP0002184_abnormal_innervation0.76794075
135MP0002938_white_spotting0.76738053
136MP0001502_abnormal_circadian_rhythm0.76424502
137MP0005671_abnormal_response_to0.74242872
138MP0001542_abnormal_bone_strength0.73931606
139MP0005451_abnormal_body_composition0.73765667
140MP0000631_abnormal_neuroendocrine_gland0.72010867
141MP0002095_abnormal_skin_pigmentation0.71939926
142MP0009697_abnormal_copulation0.71728396
143MP0008469_abnormal_protein_level0.71631560
144MP0009764_decreased_sensitivity_to0.71185531
145MP0000613_abnormal_salivary_gland0.70440106
146MP0002118_abnormal_lipid_homeostasis0.70032368
147MP0003953_abnormal_hormone_level0.69873408
148MP0008260_abnormal_autophagy0.68351397
149MP0005165_increased_susceptibility_to0.67315851

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.35313224
2Abnormal mitochondria in muscle tissue (HP:0008316)6.82858495
3* Mitochondrial inheritance (HP:0001427)6.62661529
4Hepatocellular necrosis (HP:0001404)6.33311255
5Acute encephalopathy (HP:0006846)6.19631459
6Progressive macrocephaly (HP:0004481)6.05135859
7Hepatic necrosis (HP:0002605)5.62942463
8* Increased CSF lactate (HP:0002490)5.62880955
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.79228709
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.79228709
113-Methylglutaconic aciduria (HP:0003535)4.23102885
12* Increased hepatocellular lipid droplets (HP:0006565)4.05929073
13* Lactic acidosis (HP:0003128)4.04316861
14* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.01707499
15Abnormality of cells of the erythroid lineage (HP:0012130)4.01409572
16* Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.94630682
17Respiratory failure (HP:0002878)3.93773203
18* Increased intramyocellular lipid droplets (HP:0012240)3.92160894
19* Exercise intolerance (HP:0003546)3.91875582
20Cerebral edema (HP:0002181)3.91328490
21Abnormal number of erythroid precursors (HP:0012131)3.69968700
22Optic disc pallor (HP:0000543)3.69566457
23* Lipid accumulation in hepatocytes (HP:0006561)3.66167668
24* Renal Fanconi syndrome (HP:0001994)3.65469185
25* Increased serum lactate (HP:0002151)3.61021702
26* Increased muscle lipid content (HP:0009058)3.41530764
27Leukodystrophy (HP:0002415)3.38962994
28Hypothermia (HP:0002045)3.11529158
29Neuroendocrine neoplasm (HP:0100634)2.82373587
30Increased serum pyruvate (HP:0003542)2.80565401
31Abnormality of glycolysis (HP:0004366)2.80565401
32* Exertional dyspnea (HP:0002875)2.69408671
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68843745
34Reticulocytopenia (HP:0001896)2.58403390
35Macrocytic anemia (HP:0001972)2.55538058
36Pheochromocytoma (HP:0002666)2.49355846
37CNS demyelination (HP:0007305)2.48914281
38Emotional lability (HP:0000712)2.48743151
39Microvesicular hepatic steatosis (HP:0001414)2.44498225
40Type I transferrin isoform profile (HP:0003642)2.43470937
41Congenital, generalized hypertrichosis (HP:0004540)2.43186186
42X-linked dominant inheritance (HP:0001423)2.39265763
43* Abnormality of renal resorption (HP:0011038)2.37052185
44* Respiratory difficulties (HP:0002880)2.36530150
45Pallor (HP:0000980)2.30792458
46Hypoglycemic coma (HP:0001325)2.26932663
47Palpitations (HP:0001962)2.21372156
48Aplastic anemia (HP:0001915)2.21148810
49Testicular atrophy (HP:0000029)2.17273543
50Ketoacidosis (HP:0001993)2.13644751
51Myokymia (HP:0002411)2.11048104
52Lethargy (HP:0001254)2.10869664
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04854169
54Medial flaring of the eyebrow (HP:0010747)2.04393732
55Ketosis (HP:0001946)2.01123602
56Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98720981
57Progressive microcephaly (HP:0000253)1.92121779
58Abnormality of vitamin B metabolism (HP:0004340)1.91362932
59Pancreatic cysts (HP:0001737)1.91026954
60Large for gestational age (HP:0001520)1.88870973
61Molar tooth sign on MRI (HP:0002419)1.86908514
62Abnormality of midbrain morphology (HP:0002418)1.86908514
63Methylmalonic aciduria (HP:0012120)1.86412551
64Nausea (HP:0002018)1.85469474
65Cerebral hypomyelination (HP:0006808)1.84420329
66Limb dystonia (HP:0002451)1.83888024
67Muscle hypertrophy of the lower extremities (HP:0008968)1.81402353
68* Glycosuria (HP:0003076)1.80706356
69* Abnormality of urine glucose concentration (HP:0011016)1.80706356
70Opisthotonus (HP:0002179)1.80577452
71Blindness (HP:0000618)1.80093521
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79590583
73Abnormality of alanine metabolism (HP:0010916)1.79590583
74Hyperalaninemia (HP:0003348)1.79590583
75Hyperglycinemia (HP:0002154)1.79475776
76Poor suck (HP:0002033)1.79146824
77Patchy hypopigmentation of hair (HP:0011365)1.78673205
78Pancreatic fibrosis (HP:0100732)1.78463602
79Irregular epiphyses (HP:0010582)1.78030365
80Myotonia (HP:0002486)1.76931165
81Metabolic acidosis (HP:0001942)1.76880976
82Pancytopenia (HP:0001876)1.75421993
83Abnormality of the anterior horn cell (HP:0006802)1.74996592
84Degeneration of anterior horn cells (HP:0002398)1.74996592
85Generalized aminoaciduria (HP:0002909)1.74456512
86Nephrogenic diabetes insipidus (HP:0009806)1.74095610
87Congenital primary aphakia (HP:0007707)1.73819106
88Abnormal hair whorl (HP:0010721)1.73580456
89Retinal dysplasia (HP:0007973)1.73406632
90Abnormal pupillary function (HP:0007686)1.72815476
91Gliosis (HP:0002171)1.72807523
92Hyperinsulinemic hypoglycemia (HP:0000825)1.72409491
93Parakeratosis (HP:0001036)1.71519574
94* Hyperphosphaturia (HP:0003109)1.71431051
95Dicarboxylic aciduria (HP:0003215)1.71014363
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71014363
97Reduced antithrombin III activity (HP:0001976)1.70495542
98Gait imbalance (HP:0002141)1.69606956
99True hermaphroditism (HP:0010459)1.69581704
100Short tibia (HP:0005736)1.69263590
101Hypokinesia (HP:0002375)1.67829529
102Focal motor seizures (HP:0011153)1.67034983
103Abnormal protein glycosylation (HP:0012346)1.65829156
104Abnormal glycosylation (HP:0012345)1.65829156
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65829156
106Abnormal protein N-linked glycosylation (HP:0012347)1.65829156
107Methylmalonic acidemia (HP:0002912)1.65665931
108Calf muscle hypertrophy (HP:0008981)1.65443660
109Aplasia/Hypoplasia of the tibia (HP:0005772)1.63742196
110Nonprogressive disorder (HP:0003680)1.62802415
111Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61865669
112Oral leukoplakia (HP:0002745)1.61857561
113Abnormality of serum amino acid levels (HP:0003112)1.61486451
114Abnormality of magnesium homeostasis (HP:0004921)1.61080621
115Muscle fiber atrophy (HP:0100295)1.61043226
116Type 2 muscle fiber atrophy (HP:0003554)1.60760075
117Abnormality of the heme biosynthetic pathway (HP:0010472)1.56761083
118Aplasia/hypoplasia of the uterus (HP:0008684)1.56483241
119Metaphyseal dysplasia (HP:0100255)1.56251009
120Abnormality of fatty-acid metabolism (HP:0004359)1.56124396
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.55694244
122Amniotic constriction ring (HP:0009775)1.55412316
123Abnormality of placental membranes (HP:0011409)1.55412316
124Ragged-red muscle fibers (HP:0003200)1.55101349
125Petechiae (HP:0000967)1.54235686
126Esophageal neoplasm (HP:0100751)1.53622965
127Neoplasm of head and neck (HP:0012288)1.53622965
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.53573039
129* Renal tubular dysfunction (HP:0000124)1.52392983
130Congenital sensorineural hearing impairment (HP:0008527)1.52132089
131Vomiting (HP:0002013)1.50666845
132Congenital ichthyosiform erythroderma (HP:0007431)1.49899147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.68340266
2NME24.21859353
3TAOK33.86657116
4STK163.58529943
5MAP3K123.46224241
6MUSK3.38730479
7ARAF3.31298692
8NME12.68687701
9MYLK2.51842576
10PIM22.23638443
11CASK2.22264999
12CDK192.06000756
13FRK1.93562045
14VRK11.80559759
15TESK11.76875066
16GRK71.75904048
17MAP2K71.74774213
18TNIK1.73653019
19BUB11.69702400
20ADRBK21.67320148
21PDK21.61506178
22NUAK11.60698868
23MAP4K21.57445363
24GRK51.48768891
25BMPR1B1.43306992
26BMPR21.41683526
27BRAF1.37570142
28MAPKAPK51.36747676
29STK391.29644132
30OXSR11.28173460
31BCKDK1.25480033
32OBSCN1.20902201
33MST41.14824964
34IRAK41.14122401
35CDK81.13408187
36TLK11.11436762
37ILK1.11283033
38PBK1.06227200
39WNK41.03083496
40LIMK11.02785852
41ACVR1B0.99225416
42CSNK1G20.98608943
43CCNB10.97527693
44IRAK30.96228555
45MAPK150.96083470
46TRIM280.95372006
47TIE10.93826724
48CAMKK20.92481861
49INSRR0.91060140
50CAMK2D0.89541276
51CSNK1G30.87326045
52ABL20.84992787
53IKBKB0.84820815
54CAMK2B0.84488432
55EIF2AK30.84201142
56MAPK130.83892587
57EPHB20.82907001
58DYRK20.82686799
59TEC0.82556570
60CAMK2G0.81905075
61MAPKAPK30.81890024
62ZAK0.81760650
63PLK40.81183998
64RIPK40.80410610
65TXK0.79262540
66NEK10.78085152
67PINK10.77233863
68SRPK10.76817418
69BCR0.76029622
70DAPK30.75486085
71PIK3CA0.72622003
72CAMK2A0.69068346
73PLK30.67753641
74PRKCI0.66077289
75PAK30.65726388
76CSNK1A1L0.63450128
77PRKCG0.63113611
78MAP3K110.63111150
79TESK20.61272320
80PHKG10.61066077
81PHKG20.61066077
82WEE10.60813229
83SYK0.60479305
84DAPK10.59064407
85ADRBK10.57771445
86IRAK10.57054399
87ERBB30.56768297
88PLK20.56727038
89PTK2B0.56523990
90CSNK2A20.55639714
91SCYL20.55571715
92DAPK20.54626765
93TAF10.54095052
94PRKCE0.53583493
95STK40.52196409
96SIK30.52137017
97KIT0.51903078
98RAF10.51749810
99NTRK30.51427846
100LRRK20.50650537
101EIF2AK10.50292286
102PIK3CG0.49941446
103CAMK10.49641977
104AURKA0.48999012
105KDR0.47532249
106BTK0.47095121
107PAK10.45044797
108CSNK1G10.44832087
109STK240.44588311
110PRKACA0.44155583
111LMTK20.43847376
112CSNK1A10.42034065
113IKBKE0.41217961
114PLK10.40924564
115PRKCQ0.40877617
116PRKCA0.40601431
117TNK20.40547233
118MAP2K20.40323112
119EIF2AK20.39736227
120TBK10.39624880
121UHMK10.39441371
122GRK10.39076045
123AURKB0.38784852
124RPS6KA50.37872941
125PRPF4B0.37387553
126MOS0.36695446
127GRK60.36473053
128PRKG20.36044425
129MAP2K60.35574993
130CSNK2A10.33740742
131YES10.33506636
132WNK30.32692715
133PNCK0.32087582
134NEK60.31939050
135PKN10.31177728
136ITK0.28519453
137PRKCD0.28253723

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.48823436
2Parkinsons disease_Homo sapiens_hsa050125.58812941
3Ribosome_Homo sapiens_hsa030104.68945974
4Alzheimers disease_Homo sapiens_hsa050104.27031043
5Huntingtons disease_Homo sapiens_hsa050163.91773555
6Proteasome_Homo sapiens_hsa030503.55683688
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.53072992
8Protein export_Homo sapiens_hsa030603.11498527
9Cardiac muscle contraction_Homo sapiens_hsa042602.79290718
10RNA polymerase_Homo sapiens_hsa030202.72040178
11Collecting duct acid secretion_Homo sapiens_hsa049661.88649721
12Pyrimidine metabolism_Homo sapiens_hsa002401.60142225
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57684639
14Sulfur metabolism_Homo sapiens_hsa009201.44435834
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41273565
16Vibrio cholerae infection_Homo sapiens_hsa051101.39353296
17Fatty acid elongation_Homo sapiens_hsa000621.39130080
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35528031
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32643217
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28610227
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20335886
22Purine metabolism_Homo sapiens_hsa002301.09355620
23Rheumatoid arthritis_Homo sapiens_hsa053230.96599050
24Primary bile acid biosynthesis_Homo sapiens_hsa001200.95992097
25Tryptophan metabolism_Homo sapiens_hsa003800.93142605
26Homologous recombination_Homo sapiens_hsa034400.92926403
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91031480
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90737016
29Chemical carcinogenesis_Homo sapiens_hsa052040.89307010
30Synaptic vesicle cycle_Homo sapiens_hsa047210.89242501
31Metabolic pathways_Homo sapiens_hsa011000.88084284
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83643819
33Arachidonic acid metabolism_Homo sapiens_hsa005900.77353342
34One carbon pool by folate_Homo sapiens_hsa006700.77043227
35Vitamin B6 metabolism_Homo sapiens_hsa007500.76953507
36Nicotine addiction_Homo sapiens_hsa050330.76828651
37Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75080091
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73639075
39Caffeine metabolism_Homo sapiens_hsa002320.73285903
40Nitrogen metabolism_Homo sapiens_hsa009100.72153066
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71463365
42Folate biosynthesis_Homo sapiens_hsa007900.70910768
43Taste transduction_Homo sapiens_hsa047420.70352642
44Pyruvate metabolism_Homo sapiens_hsa006200.70188811
45Serotonergic synapse_Homo sapiens_hsa047260.69685712
46Fatty acid degradation_Homo sapiens_hsa000710.69080845
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68582593
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67862447
49Basal transcription factors_Homo sapiens_hsa030220.67138245
50Nucleotide excision repair_Homo sapiens_hsa034200.66676090
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.65749523
52DNA replication_Homo sapiens_hsa030300.65502961
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65472607
54Phenylalanine metabolism_Homo sapiens_hsa003600.64549916
55Glutathione metabolism_Homo sapiens_hsa004800.64544431
56Fanconi anemia pathway_Homo sapiens_hsa034600.64297046
57Phototransduction_Homo sapiens_hsa047440.63793039
58Spliceosome_Homo sapiens_hsa030400.63067767
59Regulation of autophagy_Homo sapiens_hsa041400.62341463
60Sulfur relay system_Homo sapiens_hsa041220.61172639
61Propanoate metabolism_Homo sapiens_hsa006400.60793423
62beta-Alanine metabolism_Homo sapiens_hsa004100.56576440
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56491325
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56466124
65Fatty acid metabolism_Homo sapiens_hsa012120.56382193
66RNA degradation_Homo sapiens_hsa030180.56215427
67Mismatch repair_Homo sapiens_hsa034300.53691015
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53604167
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53081595
70Retinol metabolism_Homo sapiens_hsa008300.52132871
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52129237
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51986263
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51749303
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.49783009
75Other glycan degradation_Homo sapiens_hsa005110.48961507
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.48788613
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44884876
78Phagosome_Homo sapiens_hsa041450.43603504
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42735783
80Sphingolipid metabolism_Homo sapiens_hsa006000.42163843
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41432502
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40840430
83Selenocompound metabolism_Homo sapiens_hsa004500.40423318
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39472829
85Allograft rejection_Homo sapiens_hsa053300.38701756
86RNA transport_Homo sapiens_hsa030130.38429018
87Systemic lupus erythematosus_Homo sapiens_hsa053220.37648495
88Calcium signaling pathway_Homo sapiens_hsa040200.36933003
89Olfactory transduction_Homo sapiens_hsa047400.35302259
90Base excision repair_Homo sapiens_hsa034100.34316716
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33992093
92Circadian entrainment_Homo sapiens_hsa047130.33801735
93Autoimmune thyroid disease_Homo sapiens_hsa053200.33388690
94Type I diabetes mellitus_Homo sapiens_hsa049400.33159869
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32751331
96GABAergic synapse_Homo sapiens_hsa047270.31040887
97Ether lipid metabolism_Homo sapiens_hsa005650.31005159
98Fructose and mannose metabolism_Homo sapiens_hsa000510.30613151
99Fat digestion and absorption_Homo sapiens_hsa049750.30202334
100Antigen processing and presentation_Homo sapiens_hsa046120.30126926
101Morphine addiction_Homo sapiens_hsa050320.29420545
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29034521
103Graft-versus-host disease_Homo sapiens_hsa053320.28467825
104N-Glycan biosynthesis_Homo sapiens_hsa005100.27984925
105Carbon metabolism_Homo sapiens_hsa012000.26904028
106Vitamin digestion and absorption_Homo sapiens_hsa049770.26745971
107Amphetamine addiction_Homo sapiens_hsa050310.26614222
108Linoleic acid metabolism_Homo sapiens_hsa005910.24813938
109Arginine and proline metabolism_Homo sapiens_hsa003300.24142896
110Asthma_Homo sapiens_hsa053100.23989771
111Peroxisome_Homo sapiens_hsa041460.22101238
112Galactose metabolism_Homo sapiens_hsa000520.20574538
113Glutamatergic synapse_Homo sapiens_hsa047240.20164283
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18757719
115Salivary secretion_Homo sapiens_hsa049700.18366845
116Cholinergic synapse_Homo sapiens_hsa047250.16345728
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.16219550
118Alcoholism_Homo sapiens_hsa050340.15518529
119Epstein-Barr virus infection_Homo sapiens_hsa051690.15200667
120Dopaminergic synapse_Homo sapiens_hsa047280.14744620
121Insulin secretion_Homo sapiens_hsa049110.13542565
122Pentose phosphate pathway_Homo sapiens_hsa000300.13440335
123African trypanosomiasis_Homo sapiens_hsa051430.11944070
124Cocaine addiction_Homo sapiens_hsa050300.11475186
125Tyrosine metabolism_Homo sapiens_hsa003500.10513032
126Primary immunodeficiency_Homo sapiens_hsa053400.10148586
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09421629
128Butanoate metabolism_Homo sapiens_hsa006500.08906511
129Pertussis_Homo sapiens_hsa051330.07952221
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06298329
131Mineral absorption_Homo sapiens_hsa049780.06289370
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.06129492

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