CORO7-PAM16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring CORO7 (coronin 7) and PAM16 (presequence translocase-associated motor 16) genes on chromosome 16. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)5.99136659
2T-helper 1 type immune response (GO:0042088)5.35482353
3antigen processing and presentation of endogenous antigen (GO:0019883)5.03018716
4B cell mediated immunity (GO:0019724)4.70085417
5positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.68623513
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62291627
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53417247
8innate immune response in mucosa (GO:0002227)4.47163929
9regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.25085982
10negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.16314554
11positive regulation of B cell differentiation (GO:0045579)4.12554078
12regulation of B cell receptor signaling pathway (GO:0050855)4.12061551
13B cell receptor signaling pathway (GO:0050853)4.03543083
14positive regulation of gamma-delta T cell activation (GO:0046645)4.02660385
15negative regulation of B cell apoptotic process (GO:0002903)4.02270114
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00044523
17negative thymic T cell selection (GO:0045060)3.95673076
18interferon-gamma-mediated signaling pathway (GO:0060333)3.95553746
19B cell proliferation (GO:0042100)3.92402328
20positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.91520363
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.90988774
22regulation of B cell apoptotic process (GO:0002902)3.89980602
23positive regulation by symbiont of host defense response (GO:0052509)3.89869763
24modulation by symbiont of host defense response (GO:0052031)3.89869763
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89869763
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89869763
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.89869763
28modulation by symbiont of host immune response (GO:0052553)3.89869763
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.85596215
30negative T cell selection (GO:0043383)3.84933435
31B cell homeostasis (GO:0001782)3.81464178
32mucosal immune response (GO:0002385)3.80879750
33positive regulation of alpha-beta T cell proliferation (GO:0046641)3.67513870
34regulation of interferon-gamma biosynthetic process (GO:0045072)3.66708019
35cellular response to type I interferon (GO:0071357)3.66049059
36type I interferon signaling pathway (GO:0060337)3.66049059
37detection of bacterium (GO:0016045)3.58664593
38organ or tissue specific immune response (GO:0002251)3.56655032
39regulation of alpha-beta T cell proliferation (GO:0046640)3.56049382
40response to type I interferon (GO:0034340)3.54986317
41NIK/NF-kappaB signaling (GO:0038061)3.54805206
42negative regulation of cell killing (GO:0031342)3.49651819
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49651819
44positive regulation of humoral immune response (GO:0002922)3.49249671
45response to peptidoglycan (GO:0032494)3.46239081
46regulation of interferon-beta biosynthetic process (GO:0045357)3.43690937
47detection of other organism (GO:0098543)3.40597297
48T cell migration (GO:0072678)3.36615026
49positive regulation of T cell mediated cytotoxicity (GO:0001916)3.35393452
50chaperone mediated protein folding requiring cofactor (GO:0051085)3.34295141
51regulation of antigen processing and presentation (GO:0002577)3.28617988
52positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.28086165
53positive regulation of macrophage cytokine production (GO:0060907)3.26079379
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24815102
55antibacterial humoral response (GO:0019731)3.20823493
56negative regulation of myeloid cell apoptotic process (GO:0033033)3.20246327
57regulation of gamma-delta T cell activation (GO:0046643)3.16239153
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14422985
59response to host immune response (GO:0052572)3.14422985
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13702036
61cellular response to interleukin-15 (GO:0071350)3.12674350
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11430369
63antimicrobial humoral response (GO:0019730)3.08987491
64response to muramyl dipeptide (GO:0032495)3.08116892
65positive regulation of antigen processing and presentation (GO:0002579)3.06971339
66cellular response to interferon-beta (GO:0035458)3.06860646
67adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.06727108
68respiratory burst (GO:0045730)3.05902809
69positive regulation of interferon-gamma production (GO:0032729)3.05828813
70positive regulation of B cell proliferation (GO:0030890)3.03103728
71regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.02928501
72myeloid dendritic cell differentiation (GO:0043011)3.02361513
73negative regulation of interleukin-12 production (GO:0032695)3.00784060
74regulation of B cell proliferation (GO:0030888)3.00740083
75cellular response to interferon-gamma (GO:0071346)2.99868315
76myeloid dendritic cell activation (GO:0001773)2.97486984
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97053565
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96787488
79regulation of inflammatory response to antigenic stimulus (GO:0002861)2.95140237
80regulation of T cell mediated cytotoxicity (GO:0001914)2.94445698
81lymphocyte homeostasis (GO:0002260)2.93754632
82regulation of B cell differentiation (GO:0045577)2.92995924
83response to protozoan (GO:0001562)2.91257357
84negative regulation of B cell proliferation (GO:0030889)2.89836795
85production of molecular mediator of immune response (GO:0002440)2.89592763
86positive thymic T cell selection (GO:0045059)2.88922366
87neutrophil activation involved in immune response (GO:0002283)2.87562551
88positive regulation of B cell activation (GO:0050871)2.87313309
89regulation of interferon-alpha production (GO:0032647)2.87301203
90regulation of hypersensitivity (GO:0002883)2.85285087
91positive regulation of interferon-alpha production (GO:0032727)2.85273512
92positive regulation of immunoglobulin mediated immune response (GO:0002891)2.84668343
93positive regulation of B cell mediated immunity (GO:0002714)2.84668343
94response to interleukin-15 (GO:0070672)2.83411762
95positive regulation of cytokine biosynthetic process (GO:0042108)2.83113903
96response to interferon-beta (GO:0035456)2.82065887
97regulation of interleukin-12 production (GO:0032655)2.78411610
98positive regulation of interleukin-12 production (GO:0032735)2.76674828
99negative regulation of phagocytosis (GO:0050765)2.75031082
100response to host defenses (GO:0052200)2.73933202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.51850038
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.30199085
3SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.53095860
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.28040158
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90594501
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65750795
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64518662
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62273645
9MYC_22102868_ChIP-Seq_BL_Human2.53008771
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48677352
11VDR_21846776_ChIP-Seq_THP-1_Human2.47299191
12MAF_26560356_Chip-Seq_TH1_Human2.31887638
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29247778
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.18340071
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.06899727
16MYB_26560356_Chip-Seq_TH2_Human2.06214514
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04101646
18VDR_24763502_ChIP-Seq_THP-1_Human1.90939054
19SPI1_23547873_ChIP-Seq_NB4_Human1.89522546
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88511548
21GATA1_22025678_ChIP-Seq_K562_Human1.86598416
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82479913
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81147697
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.79570224
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78523110
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75315292
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.72743365
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72358029
29UTX_26944678_Chip-Seq_JUKART_Human1.72065340
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69000625
31VDR_23849224_ChIP-Seq_CD4+_Human1.67524670
32MYB_26560356_Chip-Seq_TH1_Human1.66873141
33CIITA_25753668_ChIP-Seq_RAJI_Human1.66670331
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65253214
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64437903
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63018375
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59077335
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58757206
39HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.57811856
40SCL_19346495_ChIP-Seq_HPC-7_Human1.53650304
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52842363
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49492412
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.48876187
44MAF_26560356_Chip-Seq_TH2_Human1.48661658
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48650185
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45180657
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44889134
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43905879
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.43759323
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41408638
51GATA3_27048872_Chip-Seq_THYMUS_Human1.40460409
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39132759
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37354312
54BCOR_27268052_Chip-Seq_Bcells_Human1.35779579
55IRF1_19129219_ChIP-ChIP_H3396_Human1.33123591
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32995764
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.31688916
58BCL6_27268052_Chip-Seq_Bcells_Human1.31361118
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.31093665
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31074046
61LXR_22292898_ChIP-Seq_THP-1_Human1.30027849
62RUNX_20019798_ChIP-Seq_JUKART_Human1.28313133
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27467251
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26215121
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24755494
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20877382
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19691466
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17670082
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14637478
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14466752
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.12537987
72SPI1_20517297_ChIP-Seq_HL60_Human1.10611153
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10598103
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09152647
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08480806
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07770284
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07700703
78ZNF263_19887448_ChIP-Seq_K562_Human1.06625549
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05594360
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04384937
81TCF7_22412390_ChIP-Seq_EML_Mouse1.03507331
82TFEB_21752829_ChIP-Seq_HELA_Human1.02322107
83FOXP3_21729870_ChIP-Seq_TREG_Human1.01895847
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01131218
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00530693
86P300_27268052_Chip-Seq_Bcells_Human1.00355272
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.99879897
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.99492652
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98849786
90SPI1_23127762_ChIP-Seq_K562_Human0.98495417
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97199963
92GATA3_26560356_Chip-Seq_TH2_Human0.95818529
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94297559
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94077072
95ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93367759
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92974716
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92727436
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92390716
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92296971
100MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91108497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system4.59727505
2MP0005671_abnormal_response_to4.29621566
3MP0005645_abnormal_hypothalamus_physiol4.10764521
4MP0001835_abnormal_antigen_presentation3.96617966
5MP0001800_abnormal_humoral_immune3.25185114
6MP0001790_abnormal_immune_system3.24546464
7MP0005387_immune_system_phenotype3.24546464
8MP0005000_abnormal_immune_tolerance3.09067201
9MP0003303_peritoneal_inflammation2.98333055
10MP0003436_decreased_susceptibility_to2.92673260
11MP0002723_abnormal_immune_serum2.68890938
12MP0009785_altered_susceptibility_to2.67873833
13MP0002452_abnormal_antigen_presenting2.63587021
14MP0005025_abnormal_response_to2.61064427
15MP0003724_increased_susceptibility_to2.58426017
16MP0002148_abnormal_hypersensitivity_rea2.47725289
17MP0002420_abnormal_adaptive_immunity2.46088268
18MP0003763_abnormal_thymus_physiology2.43261501
19MP0001819_abnormal_immune_cell2.41094558
20MP0002419_abnormal_innate_immunity2.35753670
21MP0002398_abnormal_bone_marrow2.19461522
22MP0000716_abnormal_immune_system2.01682489
23MP0002138_abnormal_hepatobiliary_system2.01299050
24MP0003183_abnormal_peptide_metabolism1.94155464
25MP0000689_abnormal_spleen_morphology1.88746020
26MP0005464_abnormal_platelet_physiology1.76352729
27MP0001845_abnormal_inflammatory_respons1.74850593
28MP0002722_abnormal_immune_system1.71157423
29MP0010155_abnormal_intestine_physiology1.70574822
30MP0002429_abnormal_blood_cell1.70190804
31MP0002166_altered_tumor_susceptibility1.66580216
32MP0000465_gastrointestinal_hemorrhage1.65513649
33MP0005310_abnormal_salivary_gland1.58730441
34MP0005084_abnormal_gallbladder_morpholo1.56003803
35MP0001853_heart_inflammation1.51868152
36MP0009333_abnormal_splenocyte_physiolog1.44717797
37MP0006082_CNS_inflammation1.44407614
38MP0008469_abnormal_protein_level1.43380318
39MP0003172_abnormal_lysosome_physiology1.42060894
40MP0005058_abnormal_lysosome_morphology1.41122402
41MP0008260_abnormal_autophagy1.40464186
42MP0003300_gastrointestinal_ulcer1.39569443
43MP0009764_decreased_sensitivity_to1.39216245
44MP0000703_abnormal_thymus_morphology1.36554227
45MP0002405_respiratory_system_inflammati1.35717881
46MP0003806_abnormal_nucleotide_metabolis1.33977922
47MP0001545_abnormal_hematopoietic_system1.28578470
48MP0005397_hematopoietic_system_phenotyp1.28578470
49MP0009046_muscle_twitch1.25985688
50MP0009278_abnormal_bone_marrow1.24820088
51MP0001348_abnormal_lacrimal_gland1.21805414
52MP0001533_abnormal_skeleton_physiology1.18831752
53MP0002006_tumorigenesis1.16969481
54MP0002396_abnormal_hematopoietic_system1.15518070
55MP0004510_myositis1.10007596
56MP0005451_abnormal_body_composition1.07816714
57MP0004947_skin_inflammation1.06525838
58MP0001727_abnormal_embryo_implantation1.05051072
59MP0006036_abnormal_mitochondrial_physio1.01731016
60MP0001873_stomach_inflammation0.99359732
61MP0005075_abnormal_melanosome_morpholog0.98811680
62MP0005166_decreased_susceptibility_to0.97499523
63MP0003075_altered_response_to0.93765534
64MP0005410_abnormal_fertilization0.93038315
65MP0002132_abnormal_respiratory_system0.91890051
66MP0003656_abnormal_erythrocyte_physiolo0.90767337
67MP0000372_irregular_coat_pigmentation0.89543428
68MP0002019_abnormal_tumor_incidence0.87221032
69MP0003646_muscle_fatigue0.84518303
70MP0000858_altered_metastatic_potential0.82692287
71MP0002933_joint_inflammation0.82423360
72MP0000490_abnormal_crypts_of0.80436048
73MP0002332_abnormal_exercise_endurance0.78034170
74MP0002837_dystrophic_cardiac_calcinosis0.76050227
75MP0009763_increased_sensitivity_to0.74696827
76MP0001764_abnormal_homeostasis0.74563748
77MP0002277_abnormal_respiratory_mucosa0.74381282
78MP0004808_abnormal_hematopoietic_stem0.71101530
79MP0002693_abnormal_pancreas_physiology0.70937612
80MP0000343_altered_response_to0.69840084
81MP0003191_abnormal_cellular_cholesterol0.68575326
82MP0000249_abnormal_blood_vessel0.68009206
83MP0005379_endocrine/exocrine_gland_phen0.67752429
84MP0002136_abnormal_kidney_physiology0.66320866
85MP0001542_abnormal_bone_strength0.63601930
86MP0000015_abnormal_ear_pigmentation0.63549582
87MP0009643_abnormal_urine_homeostasis0.63184552
88MP0005165_increased_susceptibility_to0.62815258
89MP0009840_abnormal_foam_cell0.62384134
90MP0005584_abnormal_enzyme/coenzyme_acti0.59776398
91MP0000313_abnormal_cell_death0.58215501
92MP0010094_abnormal_chromosome_stability0.57043406
93MP0002254_reproductive_system_inflammat0.54828386
94MP0003878_abnormal_ear_physiology0.54500082
95MP0005377_hearing/vestibular/ear_phenot0.54500082
96MP0009765_abnormal_xenobiotic_induced0.53810936
97MP0003866_abnormal_defecation0.52975998
98MP0005319_abnormal_enzyme/_coenzyme0.52458650
99MP0005647_abnormal_sex_gland0.51798606
100MP0001663_abnormal_digestive_system0.51514055

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)6.34373089
2Recurrent sinusitis (HP:0011108)5.36042332
3Agammaglobulinemia (HP:0004432)4.83318010
4Elevated erythrocyte sedimentation rate (HP:0003565)4.24606290
5Lymphopenia (HP:0001888)4.22115738
6Meningitis (HP:0001287)4.10593038
7IgM deficiency (HP:0002850)4.04065306
8IgA deficiency (HP:0002720)4.02878770
9Recurrent bronchitis (HP:0002837)3.91828671
10Eczematoid dermatitis (HP:0000976)3.88697724
11Vasculitis (HP:0002633)3.87150104
12Abnormality of macrophages (HP:0004311)3.80422766
13Urticaria (HP:0001025)3.80315588
14Abnormality of cells of the lymphoid lineage (HP:0012140)3.79115116
15Petechiae (HP:0000967)3.64170385
16Recurrent bacterial skin infections (HP:0005406)3.57986066
17IgG deficiency (HP:0004315)3.55215648
18Mediastinal lymphadenopathy (HP:0100721)3.55188916
19Recurrent pneumonia (HP:0006532)3.50251250
20Cellulitis (HP:0100658)3.42216607
21Recurrent abscess formation (HP:0002722)3.32712035
22Dry hair (HP:0011359)3.28960409
23Chronic diarrhea (HP:0002028)3.20417346
24Recurrent lower respiratory tract infections (HP:0002783)3.16868015
25Obstructive lung disease (HP:0006536)3.13982765
26Chronic obstructive pulmonary disease (HP:0006510)3.13982765
27Emphysema (HP:0002097)3.13373421
28Abnormality of T cell physiology (HP:0011840)3.10707867
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.02778337
30Panhypogammaglobulinemia (HP:0003139)3.02063130
31Restrictive lung disease (HP:0002091)2.95943269
32Muscle fiber atrophy (HP:0100295)2.85726723
33Onycholysis (HP:0001806)2.77559378
34Abnormal gallbladder physiology (HP:0012438)2.76926273
35Cholecystitis (HP:0001082)2.76926273
36Type 2 muscle fiber atrophy (HP:0003554)2.71804342
37Hypertensive crisis (HP:0100735)2.69377985
38Recurrent fungal infections (HP:0002841)2.68368699
39Increased IgM level (HP:0003496)2.66858090
40Myositis (HP:0100614)2.65545093
41Recurrent gram-negative bacterial infections (HP:0005420)2.62357036
42Skin rash (HP:0000988)2.60544308
43Increased IgE level (HP:0003212)2.55601592
44Recurrent viral infections (HP:0004429)2.55235447
45Leukopenia (HP:0001882)2.53718933
46Recurrent skin infections (HP:0001581)2.51277425
47Chronic mucocutaneous candidiasis (HP:0002728)2.50506614
48Recurrent cutaneous fungal infections (HP:0011370)2.50506614
49Optic neuritis (HP:0100653)2.50326930
50Retrobulbar optic neuritis (HP:0100654)2.50326930
51Gastrointestinal inflammation (HP:0004386)2.49830912
52Premature loss of primary teeth (HP:0006323)2.46086025
53Sepsis (HP:0100806)2.43287708
54Abnormality of T cells (HP:0002843)2.43017597
55Osteomyelitis (HP:0002754)2.38249907
56Inflammation of the large intestine (HP:0002037)2.37974589
57Vacuolated lymphocytes (HP:0001922)2.37232031
58Abnormality of placental membranes (HP:0011409)2.36145520
59Amniotic constriction ring (HP:0009775)2.36145520
60Purpura (HP:0000979)2.32087753
61Encephalitis (HP:0002383)2.30663419
62Erythema (HP:0010783)2.29171775
63Colitis (HP:0002583)2.28004374
64Recurrent otitis media (HP:0000403)2.27621264
65Orchitis (HP:0100796)2.26219057
66Stomatitis (HP:0010280)2.25296469
67Popliteal pterygium (HP:0009756)2.24525278
68Arthralgia (HP:0002829)2.23797957
69Prolonged neonatal jaundice (HP:0006579)2.22515532
70Hypergammaglobulinemia (HP:0010702)2.20933957
71Neutropenia (HP:0001875)2.20255851
72Asymmetric septal hypertrophy (HP:0001670)2.16040456
73Xerostomia (HP:0000217)2.15038763
74Pulmonary infiltrates (HP:0002113)2.13469982
75Lymphoma (HP:0002665)2.10543643
76Bronchitis (HP:0012387)2.09808836
77Acute hepatic failure (HP:0006554)2.06567681
78Verrucae (HP:0200043)2.04844273
79Papilloma (HP:0012740)2.04844273
80Abnormality of the prostate (HP:0008775)2.03222281
81Conical tooth (HP:0000698)2.02610377
82Abnormality of the pleura (HP:0002103)2.01246466
83Pulmonary fibrosis (HP:0002206)2.01171125
84Easy fatigability (HP:0003388)2.00565312
85Squamous cell carcinoma (HP:0002860)1.99499553
86Chronic otitis media (HP:0000389)1.97070807
87Chest pain (HP:0100749)1.93623220
88Lipid accumulation in hepatocytes (HP:0006561)1.92635413
89Renal Fanconi syndrome (HP:0001994)1.92404272
90Basal cell carcinoma (HP:0002671)1.90914562
91Fetal akinesia sequence (HP:0001989)1.88620161
92Hepatosplenomegaly (HP:0001433)1.86604662
93Abnormality of liposaccharide metabolism (HP:0010968)1.86321526
94Abnormality of glycosphingolipid metabolism (HP:0004343)1.86321526
95Abnormality of glycolipid metabolism (HP:0010969)1.86321526
96Autoimmune thrombocytopenia (HP:0001973)1.85752706
97B lymphocytopenia (HP:0010976)1.84812268
98Gastrointestinal infarctions (HP:0005244)1.83710403
99Cutaneous photosensitivity (HP:0000992)1.81687681
100Hepatocellular necrosis (HP:0001404)1.80285372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK14.59709151
2MAP4K13.96867364
3ZAK3.64356158
4TLK13.60990810
5IRAK43.33791340
6BCKDK2.94721201
7MAP3K132.80078799
8TESK22.74100932
9RIPK42.72229862
10DAPK32.58515705
11TBK12.56961049
12MAP3K142.39176226
13ARAF2.26366409
14INSRR2.22798788
15MAP3K112.02975002
16IKBKE1.94019457
17IKBKB1.93005747
18RPS6KA51.81677148
19PIM21.68982087
20SYK1.63087441
21BLK1.55420889
22JAK31.50419742
23CSF1R1.48964598
24TXK1.47277964
25BTK1.42919659
26VRK21.42895560
27TNK21.41781685
28IRAK31.39641255
29AURKA1.38467950
30SMG11.38408723
31CDK191.32688306
32KDR1.26553567
33PIM11.20787285
34ERN11.19645516
35LYN1.16596896
36BRD41.16091781
37TAOK21.07157777
38KIT1.06967140
39PRPF4B1.01134989
40MOS0.97018509
41STK100.96968663
42TAOK30.96814297
43MAP3K10.96164801
44NEK90.91663169
45PIK3CG0.86683800
46MAP2K30.84478082
47BMPR20.84387401
48TYK20.83689811
49TAOK10.80918365
50CSK0.80075018
51MATK0.78708701
52RAF10.75646403
53KSR20.73512925
54MAPK70.71537167
55FES0.70649972
56ITK0.68088857
57LCK0.67339244
58MARK30.67291858
59PRKCQ0.66973510
60PASK0.66875209
61PLK40.66712925
62CCNB10.65891409
63MAP3K120.64367952
64CHUK0.63499936
65GRK60.61407861
66DAPK10.61001866
67MAP3K90.60860919
68HCK0.58348256
69JAK20.55916252
70STK40.55286942
71NME20.50955839
72CAMKK10.50930499
73JAK10.50118733
74MAP3K80.49738954
75MAP2K20.49504875
76TESK10.45884615
77PDK10.44644441
78MAPKAPK30.41589273
79MAPK120.41567180
80MAP3K50.41360866
81SIK30.40847484
82TEC0.40674502
83DYRK1B0.38897661
84BRAF0.37180030
85EIF2AK20.35338320
86PKN10.34950269
87IRAK10.34038928
88GRK70.32160365
89MAPK110.32075204
90TAF10.31137388
91AKT20.30552152
92EIF2AK30.29872647
93ZAP700.29430432
94IRAK20.29145865
95CSNK1G30.28212589
96TRPM70.27160646
97CAMKK20.26857774
98ABL10.26630864
99PRKCD0.26510094
100LIMK10.24269103

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.83104711
2Alcoholism_Homo sapiens_hsa050344.13929105
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.97047932
4Allograft rejection_Homo sapiens_hsa053303.88840822
5Primary immunodeficiency_Homo sapiens_hsa053403.74185499
6Asthma_Homo sapiens_hsa053103.73443031
7Autoimmune thyroid disease_Homo sapiens_hsa053203.55438899
8Graft-versus-host disease_Homo sapiens_hsa053323.07032562
9Type I diabetes mellitus_Homo sapiens_hsa049402.74781678
10Leishmaniasis_Homo sapiens_hsa051402.50238810
11Viral myocarditis_Homo sapiens_hsa054162.41972769
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.25888686
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19210103
14Antigen processing and presentation_Homo sapiens_hsa046122.05829632
15Viral carcinogenesis_Homo sapiens_hsa052031.95446233
16Staphylococcus aureus infection_Homo sapiens_hsa051501.86919016
17B cell receptor signaling pathway_Homo sapiens_hsa046621.84538617
18Rheumatoid arthritis_Homo sapiens_hsa053231.63562450
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.59190240
20Hematopoietic cell lineage_Homo sapiens_hsa046401.52483747
21Herpes simplex infection_Homo sapiens_hsa051681.45382075
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.28122819
23Tuberculosis_Homo sapiens_hsa051521.28007343
24Influenza A_Homo sapiens_hsa051641.27324766
25Osteoclast differentiation_Homo sapiens_hsa043801.19919875
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18121625
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12557184
28Epstein-Barr virus infection_Homo sapiens_hsa051691.07950514
29Pentose phosphate pathway_Homo sapiens_hsa000301.04947917
30Toxoplasmosis_Homo sapiens_hsa051451.03593748
31Measles_Homo sapiens_hsa051620.99976173
32Phagosome_Homo sapiens_hsa041450.97776328
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87973728
34Base excision repair_Homo sapiens_hsa034100.81463598
35Fructose and mannose metabolism_Homo sapiens_hsa000510.73524848
36Other glycan degradation_Homo sapiens_hsa005110.72642804
37Proteasome_Homo sapiens_hsa030500.71899538
38T cell receptor signaling pathway_Homo sapiens_hsa046600.68572202
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65038407
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64228419
41Shigellosis_Homo sapiens_hsa051310.63160126
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62993264
43Acute myeloid leukemia_Homo sapiens_hsa052210.62783623
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62611653
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61177704
46Malaria_Homo sapiens_hsa051440.60446705
47Lysosome_Homo sapiens_hsa041420.59606693
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.58325064
49TNF signaling pathway_Homo sapiens_hsa046680.58004356
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55754331
51Legionellosis_Homo sapiens_hsa051340.54293308
52HTLV-I infection_Homo sapiens_hsa051660.54029804
53Hepatitis B_Homo sapiens_hsa051610.52736272
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51014253
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.49236306
56Apoptosis_Homo sapiens_hsa042100.48776142
57Carbon metabolism_Homo sapiens_hsa012000.48401818
58DNA replication_Homo sapiens_hsa030300.47276340
59Biosynthesis of amino acids_Homo sapiens_hsa012300.46180421
60Phenylalanine metabolism_Homo sapiens_hsa003600.42342322
61Chemokine signaling pathway_Homo sapiens_hsa040620.41297218
62Collecting duct acid secretion_Homo sapiens_hsa049660.40807196
63Oxidative phosphorylation_Homo sapiens_hsa001900.36745179
64Pyrimidine metabolism_Homo sapiens_hsa002400.30802191
65Sulfur relay system_Homo sapiens_hsa041220.29945394
66Hepatitis C_Homo sapiens_hsa051600.29547006
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28967794
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28694602
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28509292
70Spliceosome_Homo sapiens_hsa030400.27056242
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.26833537
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26676164
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26673500
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26119440
75Mismatch repair_Homo sapiens_hsa034300.25941019
76Salmonella infection_Homo sapiens_hsa051320.25086199
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24232816
78Pertussis_Homo sapiens_hsa051330.23923995
79Galactose metabolism_Homo sapiens_hsa000520.22514129
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20654054
81Parkinsons disease_Homo sapiens_hsa050120.19537590
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19447799
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18905280
84Vibrio cholerae infection_Homo sapiens_hsa051100.17293691
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.13283992
86African trypanosomiasis_Homo sapiens_hsa051430.12824087
87p53 signaling pathway_Homo sapiens_hsa041150.12807325
88One carbon pool by folate_Homo sapiens_hsa006700.12789136
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12532054
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.11640913
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10859072
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10558129
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.10427777
94HIF-1 signaling pathway_Homo sapiens_hsa040660.10404100
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.10112295
96Nucleotide excision repair_Homo sapiens_hsa034200.09699048
97Fatty acid elongation_Homo sapiens_hsa000620.06712736
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05981109
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05710384
100Platelet activation_Homo sapiens_hsa046110.03990446

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