CORO1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.69923721
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.69081103
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.69081103
4antigen processing and presentation of endogenous antigen (GO:0019883)6.38396879
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.78503917
6leukocyte aggregation (GO:0070486)5.36107522
7regulation of B cell receptor signaling pathway (GO:0050855)5.31789512
8regulation of gamma-delta T cell differentiation (GO:0045586)5.26263221
9negative T cell selection (GO:0043383)5.25578920
10negative thymic T cell selection (GO:0045060)5.21628121
11positive thymic T cell selection (GO:0045059)5.05486973
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.02748327
13positive regulation by organism of defense response of other organism involved in symbiotic interact5.02748327
14modulation by symbiont of host immune response (GO:0052553)5.02748327
15positive regulation by symbiont of host defense response (GO:0052509)5.02748327
16modulation by symbiont of host defense response (GO:0052031)5.02748327
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.02748327
18detection of bacterium (GO:0016045)4.94489579
19detection of other organism (GO:0098543)4.90970484
20regulation of gamma-delta T cell activation (GO:0046643)4.83335800
21response to interleukin-15 (GO:0070672)4.72734084
22negative regulation of cell killing (GO:0031342)4.70700683
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.70700683
24B cell receptor signaling pathway (GO:0050853)4.65312580
25neutrophil activation involved in immune response (GO:0002283)4.53904276
26T cell migration (GO:0072678)4.43479693
27cellular response to interleukin-15 (GO:0071350)4.41132976
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40524875
29thymic T cell selection (GO:0045061)4.38717276
30regulation of B cell differentiation (GO:0045577)4.38055489
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.37240413
32positive T cell selection (GO:0043368)4.31086449
33Arp2/3 complex-mediated actin nucleation (GO:0034314)4.17224499
34macrophage activation involved in immune response (GO:0002281)4.15621319
35T cell selection (GO:0045058)4.12967087
36positive regulation of B cell differentiation (GO:0045579)4.08056059
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.95965777
38negative regulation of leukocyte mediated immunity (GO:0002704)3.94060026
39mast cell activation (GO:0045576)3.93454251
40response to peptidoglycan (GO:0032494)3.90992497
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.88441422
42negative regulation of T cell mediated immunity (GO:0002710)3.87992051
43interferon-gamma production (GO:0032609)3.87778948
44antigen receptor-mediated signaling pathway (GO:0050851)3.85135341
45detection of external biotic stimulus (GO:0098581)3.84744448
46antigen processing and presentation via MHC class Ib (GO:0002475)3.84406277
47negative regulation of interleukin-12 production (GO:0032695)3.81463286
48regulation of interferon-beta biosynthetic process (GO:0045357)3.75865715
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.75236371
50negative regulation of phagocytosis (GO:0050765)3.73392936
51neutrophil activation (GO:0042119)3.67465308
52T cell receptor signaling pathway (GO:0050852)3.67254962
53T cell costimulation (GO:0031295)3.65263055
54lymphocyte costimulation (GO:0031294)3.60178700
55regulation of T cell receptor signaling pathway (GO:0050856)3.59129223
56response to host immune response (GO:0052572)3.50844668
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.50844668
58regulation of isotype switching to IgG isotypes (GO:0048302)3.50298510
59regulation of interleukin-12 biosynthetic process (GO:0045075)3.46751699
60leukocyte migration involved in inflammatory response (GO:0002523)3.46286185
61myeloid cell activation involved in immune response (GO:0002275)3.46065485
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.46034598
63ribosomal small subunit assembly (GO:0000028)3.44129687
64regulation of T cell mediated cytotoxicity (GO:0001914)3.43554481
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.43452161
66cellular response to zinc ion (GO:0071294)3.43062183
67immunoglobulin mediated immune response (GO:0016064)3.42119567
68regulation of alpha-beta T cell proliferation (GO:0046640)3.38978901
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.38595585
70detection of biotic stimulus (GO:0009595)3.34389776
71mast cell degranulation (GO:0043303)3.33548565
72mast cell activation involved in immune response (GO:0002279)3.33548565
73positive regulation of lamellipodium assembly (GO:0010592)3.33237626
74regulation of T cell tolerance induction (GO:0002664)3.33213425
75granulocyte activation (GO:0036230)3.33018511
76regulation of mast cell degranulation (GO:0043304)3.30871659
77sequestering of actin monomers (GO:0042989)3.30314986
78negative regulation of erythrocyte differentiation (GO:0045647)3.27611439
79response to muramyl dipeptide (GO:0032495)3.26096146
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23845174
81response to host (GO:0075136)3.23845174
82response to host defenses (GO:0052200)3.23845174
83tolerance induction (GO:0002507)3.21874388
84leukocyte degranulation (GO:0043299)3.21810419
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19742921
86NIK/NF-kappaB signaling (GO:0038061)3.18702103
87germinal center formation (GO:0002467)3.16683678
88positive regulation of interleukin-2 production (GO:0032743)3.15914571
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14295716
90regulation of type I interferon-mediated signaling pathway (GO:0060338)3.11041829
91* T cell homeostasis (GO:0043029)3.10032022
92regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09289026
93response to type I interferon (GO:0034340)3.09272256
94leukocyte cell-cell adhesion (GO:0007159)3.08955462
95cellular extravasation (GO:0045123)3.08869984
96negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.08356194
97positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07817807
98negative regulation of innate immune response (GO:0045824)3.07644651
99type I interferon signaling pathway (GO:0060337)3.06135075
100cellular response to type I interferon (GO:0071357)3.06135075
101immune response-activating cell surface receptor signaling pathway (GO:0002429)3.06039991
102regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04930292
103regulation of response to interferon-gamma (GO:0060330)3.04315032
104microglial cell activation (GO:0001774)3.03840159
105positive regulation of isotype switching (GO:0045830)3.03405142
106actin nucleation (GO:0045010)3.02073255
107regulation of mast cell activation involved in immune response (GO:0033006)3.01049053
108interferon-gamma-mediated signaling pathway (GO:0060333)3.00892787
109respiratory burst (GO:0045730)3.00387198
110detection of molecule of bacterial origin (GO:0032490)2.99616949
111regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.98244764
112B cell mediated immunity (GO:0019724)2.96867781
113* lymphocyte homeostasis (GO:0002260)2.96811597
114myeloid dendritic cell activation (GO:0001773)2.96627997
115defense response to protozoan (GO:0042832)2.95959134
116regulation of antigen processing and presentation (GO:0002577)2.94670973
117response to protozoan (GO:0001562)2.94205036
118regulation of leukocyte mediated cytotoxicity (GO:0001910)2.93749611
119regulation of leukocyte degranulation (GO:0043300)2.93714688
120mature B cell differentiation (GO:0002335)2.93550157
121neutrophil mediated immunity (GO:0002446)2.92899917
122natural killer cell activation (GO:0030101)2.91053512
123production of molecular mediator involved in inflammatory response (GO:0002532)2.90797308
124JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90250201
125negative regulation of alpha-beta T cell activation (GO:0046636)2.89967537
126regulation of interleukin-2 biosynthetic process (GO:0045076)2.89760634
127regulation of regulatory T cell differentiation (GO:0045589)2.89536221
128positive regulation of mast cell activation (GO:0033005)2.89246248
129viral transcription (GO:0019083)2.86026766
130positive regulation of lamellipodium organization (GO:1902745)2.85847905
131positive regulation of tolerance induction (GO:0002645)2.81173080
132positive regulation of granulocyte differentiation (GO:0030854)2.76589729
133lymph node development (GO:0048535)2.76458992
134cellular response to interferon-beta (GO:0035458)2.76173045
135natural killer cell differentiation (GO:0001779)2.75047977
136negative regulation of T cell receptor signaling pathway (GO:0050860)2.74856401
137positive regulation of immunoglobulin production (GO:0002639)2.74026580
138regulation of natural killer cell mediated immunity (GO:0002715)2.73368957
139regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73368957
140T cell proliferation (GO:0042098)2.71984646
141* leukocyte homeostasis (GO:0001776)2.70044778
142translational termination (GO:0006415)2.69984087
143regulation of B cell mediated immunity (GO:0002712)2.69599604
144activated T cell proliferation (GO:0050798)2.69097881
145regulation of tolerance induction (GO:0002643)2.67907772
146mature B cell differentiation involved in immune response (GO:0002313)2.67755575
147regulation of isotype switching (GO:0045191)2.65911392
148megakaryocyte development (GO:0035855)2.65810086
149positive regulation of antigen processing and presentation (GO:0002579)2.64110625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.28867003
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.41012052
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.40550314
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.08711243
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.67667891
6* MYC_22102868_ChIP-Seq_BL_Human3.45319175
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35929581
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.15252111
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14970720
10VDR_21846776_ChIP-Seq_THP-1_Human2.85931569
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.68524955
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.67667697
13* MYB_26560356_Chip-Seq_TH2_Human2.64257291
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60968353
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.55521746
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55237513
17* MAF_26560356_Chip-Seq_TH1_Human2.53418867
18SCL_19346495_ChIP-Seq_HPC-7_Human2.52947731
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.50640205
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50426012
21RUNX_20019798_ChIP-Seq_JUKART_Human2.44079004
22* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32357355
23* UTX_26944678_Chip-Seq_JUKART_Human2.32274212
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30999787
25* MYB_26560356_Chip-Seq_TH1_Human2.30829432
26* SPI1_23547873_ChIP-Seq_NB4_Human2.29076446
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20706256
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20027884
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.13518407
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09432584
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08007957
32BP1_19119308_ChIP-ChIP_Hs578T_Human2.07061986
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03912550
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.02914880
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00803472
36FOXM1_23109430_ChIP-Seq_U2OS_Human2.00496122
37* VDR_24763502_ChIP-Seq_THP-1_Human1.99918253
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93631482
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82172070
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.81669652
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.80382382
42* TCF7_22412390_ChIP-Seq_EML_Mouse1.78758860
43CIITA_25753668_ChIP-Seq_RAJI_Human1.76984647
44MAF_26560356_Chip-Seq_TH2_Human1.75314542
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72279594
46* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71120978
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70389846
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63274773
49GATA3_27048872_Chip-Seq_THYMUS_Human1.56574296
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50888064
51* SPI1_23127762_ChIP-Seq_K562_Human1.50208808
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49821428
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49111863
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48873986
55LXR_22292898_ChIP-Seq_THP-1_Human1.47826759
56VDR_23849224_ChIP-Seq_CD4+_Human1.45811571
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43099183
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43045038
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43000148
60FOXP3_21729870_ChIP-Seq_TREG_Human1.41582286
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41280924
62* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32385933
63VDR_24787735_ChIP-Seq_THP-1_Human1.29702726
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29186334
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.28779547
66BCL6_27268052_Chip-Seq_Bcells_Human1.27552409
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27172527
68* KDM2B_26808549_Chip-Seq_DND41_Human1.26907869
69* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25477352
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24945172
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23942365
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23185039
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22530635
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.22300666
75BCOR_27268052_Chip-Seq_Bcells_Human1.19015893
76PU_27001747_Chip-Seq_BMDM_Mouse1.17337697
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15836253
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14960404
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.13611957
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13559814
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12698586
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12271836
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.12169040
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09386444
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09340871
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07336160
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.07232686
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06852245
89XRN2_22483619_ChIP-Seq_HELA_Human1.06621590
90GATA3_26560356_Chip-Seq_TH2_Human1.06157614
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06110639
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04056837
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03622401
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.03095155
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.01720324
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01634516
97GATA1_19941826_ChIP-Seq_K562_Human1.01253342
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99904284
99GATA1_22025678_ChIP-Seq_K562_Human0.98082205
100MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96753864
101NCOR1_26117541_ChIP-Seq_K562_Human0.96290235
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95540055
103* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94996103
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.94775920
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.94689637
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94648400
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94073288
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.91688328
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91199449
110SPI1_20517297_ChIP-Seq_HL60_Human0.91183622
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91162586
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90568968
113ETS1_20019798_ChIP-Seq_JURKAT_Human0.90563914
114MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90276142
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89876998
116P68_20966046_ChIP-Seq_HELA_Human0.89687111
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87246511
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87119839
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86943041
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86110692
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86083380
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85945206
123GABP_19822575_ChIP-Seq_HepG2_Human0.85114912
124MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84907446
125P300_27268052_Chip-Seq_Bcells_Human0.82512821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.40120815
2MP0005671_abnormal_response_to3.87117030
3MP0000685_abnormal_immune_system3.74327650
4* MP0003763_abnormal_thymus_physiology3.67888823
5MP0001800_abnormal_humoral_immune3.49404480
6MP0001790_abnormal_immune_system3.20830356
7MP0005387_immune_system_phenotype3.20830356
8MP0009785_altered_susceptibility_to3.12382510
9MP0002396_abnormal_hematopoietic_system3.03541816
10* MP0002420_abnormal_adaptive_immunity2.96242069
11* MP0002452_abnormal_antigen_presenting2.93462059
12* MP0001819_abnormal_immune_cell2.91679884
13* MP0005000_abnormal_immune_tolerance2.90307712
14* MP0002398_abnormal_bone_marrow2.88134328
15* MP0002723_abnormal_immune_serum2.87472823
16MP0003436_decreased_susceptibility_to2.79385787
17* MP0005025_abnormal_response_to2.66329542
18MP0002166_altered_tumor_susceptibility2.56863188
19* MP0000716_abnormal_immune_system2.53984458
20MP0003303_peritoneal_inflammation2.46100491
21* MP0000689_abnormal_spleen_morphology2.35452505
22MP0002148_abnormal_hypersensitivity_rea2.31801669
23* MP0002419_abnormal_innate_immunity2.31763188
24MP0002405_respiratory_system_inflammati2.30848256
25* MP0002722_abnormal_immune_system2.30714821
26MP0009333_abnormal_splenocyte_physiolog2.27546743
27MP0005464_abnormal_platelet_physiology2.17837253
28* MP0002429_abnormal_blood_cell2.15219365
29MP0001873_stomach_inflammation2.13733703
30* MP0000703_abnormal_thymus_morphology2.13292551
31MP0002006_tumorigenesis2.03827061
32MP0004808_abnormal_hematopoietic_stem2.03058978
33MP0010155_abnormal_intestine_physiology2.02033436
34MP0006082_CNS_inflammation1.93225470
35MP0003300_gastrointestinal_ulcer1.87756147
36MP0003866_abnormal_defecation1.84544272
37MP0003724_increased_susceptibility_to1.83243931
38MP0001853_heart_inflammation1.79344736
39MP0004947_skin_inflammation1.75589873
40* MP0001845_abnormal_inflammatory_respons1.75409519
41MP0002933_joint_inflammation1.64967833
42MP0000465_gastrointestinal_hemorrhage1.60233061
43MP0001545_abnormal_hematopoietic_system1.58298317
44MP0005397_hematopoietic_system_phenotyp1.58298317
45MP0008260_abnormal_autophagy1.53941077
46MP0004510_myositis1.51079267
47MP0000490_abnormal_crypts_of1.44605343
48MP0003693_abnormal_embryo_hatching1.36141562
49MP0005174_abnormal_tail_pigmentation1.35775867
50MP0009278_abnormal_bone_marrow1.34023260
51MP0010094_abnormal_chromosome_stability1.31741942
52MP0000858_altered_metastatic_potential1.29230801
53MP0005310_abnormal_salivary_gland1.29208765
54MP0005451_abnormal_body_composition1.27769151
55MP0002019_abnormal_tumor_incidence1.25487131
56MP0008469_abnormal_protein_level1.25161456
57MP0005075_abnormal_melanosome_morpholog1.24328143
58MP0008057_abnormal_DNA_replication1.21471531
59MP0003077_abnormal_cell_cycle1.21318028
60MP0001533_abnormal_skeleton_physiology1.19668304
61MP0002277_abnormal_respiratory_mucosa1.11587585
62MP0002138_abnormal_hepatobiliary_system1.05400616
63MP0003183_abnormal_peptide_metabolism1.02199001
64MP0003448_altered_tumor_morphology1.01528973
65MP0004883_abnormal_blood_vessel1.00615024
66MP0003172_abnormal_lysosome_physiology0.98556226
67MP0002132_abnormal_respiratory_system0.95635118
68MP0002095_abnormal_skin_pigmentation0.92940191
69MP0004957_abnormal_blastocyst_morpholog0.91638451
70MP0003111_abnormal_nucleus_morphology0.91184122
71MP0000015_abnormal_ear_pigmentation0.87898578
72MP0003075_altered_response_to0.86386021
73MP0010352_gastrointestinal_tract_polyps0.85937881
74MP0008007_abnormal_cellular_replicative0.84517489
75MP0001851_eye_inflammation0.81291993
76MP0008058_abnormal_DNA_repair0.80624664
77MP0003690_abnormal_glial_cell0.80115064
78MP0003191_abnormal_cellular_cholesterol0.80112122
79MP0005058_abnormal_lysosome_morphology0.75402848
80MP0009764_decreased_sensitivity_to0.74071229
81MP0000313_abnormal_cell_death0.72760760
82MP0005390_skeleton_phenotype0.72055596
83MP0009763_increased_sensitivity_to0.69472841
84MP0000343_altered_response_to0.68539401
85MP0010307_abnormal_tumor_latency0.68303866
86MP0001663_abnormal_digestive_system0.66763613
87MP0005164_abnormal_response_to0.64188960
88MP0005023_abnormal_wound_healing0.63045088
89MP0000604_amyloidosis0.61525147
90MP0008874_decreased_physiological_sensi0.60453048
91MP0002998_abnormal_bone_remodeling0.59397499
92MP0000477_abnormal_intestine_morphology0.58819665
93MP0003806_abnormal_nucleotide_metabolis0.58394401
94MP0009765_abnormal_xenobiotic_induced0.56531645
95MP0002693_abnormal_pancreas_physiology0.55997547
96MP0005166_decreased_susceptibility_to0.55122154
97MP0000350_abnormal_cell_proliferation0.53618826
98MP0004381_abnormal_hair_follicle0.52923526
99MP0006054_spinal_hemorrhage0.52837268
100MP0008873_increased_physiological_sensi0.52139256
101MP0001986_abnormal_taste_sensitivity0.49369782
102MP0002928_abnormal_bile_duct0.48904340
103MP0003828_pulmonary_edema0.48034015
104MP0004130_abnormal_muscle_cell0.47853920
105MP0008004_abnormal_stomach_pH0.47707967
106MP0003221_abnormal_cardiomyocyte_apopto0.46394428
107MP0000249_abnormal_blood_vessel0.45934075
108MP0003795_abnormal_bone_structure0.45731316
109MP0005381_digestive/alimentary_phenotyp0.45516600
110MP0003091_abnormal_cell_migration0.45462494
111MP0005076_abnormal_cell_differentiation0.45070435
112MP0000609_abnormal_liver_physiology0.44352362
113MP0001191_abnormal_skin_condition0.43974720
114MP0002083_premature_death0.42729165
115MP0003045_fibrosis0.42372647
116MP0003943_abnormal_hepatobiliary_system0.41063567
117MP0000371_diluted_coat_color0.40871904
118* MP0002136_abnormal_kidney_physiology0.40116571
119MP0005319_abnormal_enzyme/_coenzyme0.39820563
120MP0008961_abnormal_basal_metabolism0.39648830
121MP0002009_preneoplasia0.39386096
122MP0001348_abnormal_lacrimal_gland0.38854728
123MP0003656_abnormal_erythrocyte_physiolo0.37247446
124MP0009840_abnormal_foam_cell0.36421785

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bronchitis (HP:0002837)5.21209895
2IgM deficiency (HP:0002850)5.07256724
3Chronic otitis media (HP:0000389)5.02324249
4Elevated erythrocyte sedimentation rate (HP:0003565)4.88766516
5T lymphocytopenia (HP:0005403)4.74489610
6Eczematoid dermatitis (HP:0000976)4.65737001
7Panhypogammaglobulinemia (HP:0003139)4.65625052
8Recurrent abscess formation (HP:0002722)4.65410006
9Abnormality of T cell number (HP:0011839)4.62072214
10Recurrent viral infections (HP:0004429)4.59261906
11Agammaglobulinemia (HP:0004432)4.56513954
12Recurrent fungal infections (HP:0002841)4.54032443
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.38963703
14Abnormality of T cells (HP:0002843)4.26292878
15Myositis (HP:0100614)4.10069145
16Gastrointestinal infarctions (HP:0005244)4.07839829
17Recurrent cutaneous fungal infections (HP:0011370)4.01723706
18Chronic mucocutaneous candidiasis (HP:0002728)4.01723706
19Meningitis (HP:0001287)3.97588061
20Recurrent bacterial skin infections (HP:0005406)3.94845237
21Nasal polyposis (HP:0100582)3.82703194
22Cellulitis (HP:0100658)3.81873100
23IgG deficiency (HP:0004315)3.67531186
24Severe combined immunodeficiency (HP:0004430)3.66633557
25Thrombocytosis (HP:0001894)3.62379773
26Abnormality of T cell physiology (HP:0011840)3.62326801
27Abnormality of B cell number (HP:0010975)3.60149668
28B lymphocytopenia (HP:0010976)3.60149668
29Inflammation of the large intestine (HP:0002037)3.53878508
30Combined immunodeficiency (HP:0005387)3.52941543
31Gastrointestinal inflammation (HP:0004386)3.50295553
32Thyroiditis (HP:0100646)3.44407925
33Abnormality of the nasal mucosa (HP:0000433)3.43521330
34Recurrent sinusitis (HP:0011108)3.41578314
35Recurrent skin infections (HP:0001581)3.39866460
36Urticaria (HP:0001025)3.37597875
37Mediastinal lymphadenopathy (HP:0100721)3.27905297
38Stomatitis (HP:0010280)3.22011985
39* Lymphopenia (HP:0001888)3.21369703
40Obstructive lung disease (HP:0006536)3.21129430
41Chronic obstructive pulmonary disease (HP:0006510)3.21129430
42Chronic sinusitis (HP:0011109)3.19449130
43Vasculitis (HP:0002633)3.18787543
44Keratoconjunctivitis (HP:0001096)3.17026844
45Colitis (HP:0002583)3.15984298
46* Abnormality of cells of the lymphoid lineage (HP:0012140)3.15646978
47Gastrointestinal stroma tumor (HP:0100723)3.14988946
48Pustule (HP:0200039)3.09815646
49Verrucae (HP:0200043)3.09750788
50Papilloma (HP:0012740)3.09750788
51Spontaneous hematomas (HP:0007420)3.05119096
52Hypochromic anemia (HP:0001931)2.97994212
53Bronchitis (HP:0012387)2.96461657
54Eosinophilia (HP:0001880)2.94359675
55Autoimmune thrombocytopenia (HP:0001973)2.87226859
56Abnormality of eosinophils (HP:0001879)2.87141346
57Chronic diarrhea (HP:0002028)2.86985244
58Abnormality of the fingertips (HP:0001211)2.77690490
59Leukocytosis (HP:0001974)2.77666735
60Granulocytopenia (HP:0001913)2.77371875
61Hypochromic microcytic anemia (HP:0004840)2.74341290
62Lymphoma (HP:0002665)2.72837403
63Encephalitis (HP:0002383)2.71856308
64Petechiae (HP:0000967)2.68311520
65IgA deficiency (HP:0002720)2.67860829
66Recurrent gram-negative bacterial infections (HP:0005420)2.67458972
67Increased IgE level (HP:0003212)2.60597248
68Pulmonary embolism (HP:0002204)2.56482251
69Autoimmune hemolytic anemia (HP:0001890)2.54786193
70Episodic fever (HP:0001954)2.54306888
71Prolonged bleeding time (HP:0003010)2.54069829
72Abnormality of macrophages (HP:0004311)2.53776396
73Osteomyelitis (HP:0002754)2.44728998
74Anorexia (HP:0002039)2.44724867
75Emphysema (HP:0002097)2.43555556
76Gingival bleeding (HP:0000225)2.42870207
77Orchitis (HP:0100796)2.41838865
78Hypoplasia of the thymus (HP:0000778)2.41782068
79Hemoptysis (HP:0002105)2.39982919
80Hypergammaglobulinemia (HP:0010702)2.39721496
81Retrobulbar optic neuritis (HP:0100654)2.38456807
82Optic neuritis (HP:0100653)2.38456807
83Interstitial pulmonary disease (HP:0006530)2.37026660
84Epistaxis (HP:0000421)2.34014666
85Abnormality of the pleura (HP:0002103)2.33738526
86Basal cell carcinoma (HP:0002671)2.29125726
87Chest pain (HP:0100749)2.28694852
88Sepsis (HP:0100806)2.27672374
89Recurrent lower respiratory tract infections (HP:0002783)2.25931635
90Recurrent pneumonia (HP:0006532)2.24120432
91Microcytic anemia (HP:0001935)2.23906665
92Pulmonary infiltrates (HP:0002113)2.23610339
93Skin ulcer (HP:0200042)2.20991332
94Recurrent otitis media (HP:0000403)2.17263894
95Gangrene (HP:0100758)2.16606260
96Acute hepatic failure (HP:0006554)2.16149897
97Gingivitis (HP:0000230)2.14210309
98Increased IgM level (HP:0003496)2.13960876
99Viral hepatitis (HP:0006562)2.13625340
100Skin rash (HP:0000988)2.09048210
101Poikiloderma (HP:0001029)2.07655918
102Glomerulopathy (HP:0100820)2.05032527
103Purpura (HP:0000979)2.04921661
104Abnormality of the prostate (HP:0008775)2.04836855
105Joint swelling (HP:0001386)2.04094094
106Premature loss of primary teeth (HP:0006323)2.03576913
107Restrictive lung disease (HP:0002091)2.02932483
108Reticulocytopenia (HP:0001896)2.02785867
109Periodontitis (HP:0000704)2.01427716
110Arterial thrombosis (HP:0004420)2.00875316
111Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00567672
112Hepatosplenomegaly (HP:0001433)1.98039930
113Abnormality of the peritoneum (HP:0002585)1.97878208
114Slow saccadic eye movements (HP:0000514)1.97026772
115Keratoconjunctivitis sicca (HP:0001097)1.96292953
116Papilledema (HP:0001085)1.95809480
117Abnormal platelet volume (HP:0011876)1.93465223
118Aplasia/Hypoplasia of the thymus (HP:0010515)1.92902457
119Neutropenia (HP:0001875)1.92420050
120Abnormality of cells of the erythroid lineage (HP:0012130)1.92336616
121Impaired platelet aggregation (HP:0003540)1.91150672
122Abnormal platelet function (HP:0011869)1.91150672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.80727533
2TXK3.34623346
3PRPF4B2.91866994
4ZAP702.82051959
5BLK2.77405033
6JAK32.61409491
7KIT2.45955415
8TYK22.45141509
9GRK62.40212799
10STK102.38046956
11BTK2.37029765
12EEF2K2.21561229
13ITK2.20725447
14MAP3K102.11732722
15IKBKE2.11590553
16SYK2.10349473
17TEC2.10078705
18CSF1R2.04560683
19IRAK41.99572665
20TBK11.91102734
21TESK21.76441847
22FGFR41.74517877
23LCK1.68064286
24CLK11.57380293
25MAP3K141.56048250
26LRRK21.54775562
27JAK11.51040161
28KDR1.50369892
29NME21.49570545
30FLT31.49191183
31FES1.47235660
32HCK1.44782288
33CSK1.41271393
34PKN21.35743084
35ERN11.34372043
36SMG11.31247578
37FGR1.29981697
38NLK1.26286046
39MAP3K31.25704048
40MAP3K131.25486633
41LYN1.24003671
42RIPK41.20252215
43FGFR31.20119088
44MAP2K31.12453728
45IKBKB1.06186308
46SIK21.03127459
47RPS6KA41.00501996
48MAP3K10.99739322
49TGFBR20.99643680
50TRIB30.97804280
51PIM10.94724771
52MST40.93244918
53KSR20.91324315
54MARK30.89633669
55MAP3K120.87727459
56TNK20.86240464
57NEK20.85454458
58MARK20.85207683
59YES10.84727181
60PRKCH0.83219717
61PRKD20.81246362
62TAOK20.79496722
63CDC70.78455534
64TGFBR10.77947846
65PRKCQ0.77250992
66ACVR1B0.77211976
67PTK60.71200127
68CDK40.70493896
69SIK30.69069193
70BMPR20.68938426
71JAK20.66928526
72CAMKK10.65515810
73PDPK10.61512211
74EPHB10.59850082
75MAPK70.59710970
76STK40.59227563
77CDC42BPA0.57458145
78SCYL20.56613798
79BUB10.55791328
80MAPK110.55611271
81SIK10.55153363
82IRAK10.50414779
83RPS6KB20.49947980
84MAPK40.49898420
85PDK10.49852907
86PASK0.46191553
87CAMKK20.45788125
88EIF2AK30.45547448
89MAP3K80.45470185
90CHUK0.44794750
91MAP3K60.42757992
92STK110.42530449
93IRAK30.41940539
94HIPK20.41227353
95TAOK30.41020974
96ATR0.40150661
97MAP3K70.39364436
98DYRK1B0.39098486
99TLK10.38755488
100PIK3CG0.38469935
101MAP3K50.38389866
102TAOK10.38183690
103ALK0.38068305
104IRAK20.37974086
105CCNB10.37968171
106PIM20.37811200
107MAP3K110.37507161
108RET0.35722523
109RPS6KA60.35405499
110EPHA30.32688207
111MAPKAPK20.32606450
112FYN0.32366976
113RAF10.32366036
114MAP2K20.32139419
115MAP2K60.32008424
116TESK10.30482002
117ADRBK20.30409017
118MATK0.29925929
119PTK2B0.29440484
120DAPK10.29413756
121MAPK120.28872665
122TRPM70.28017514
123WEE10.27783419
124PRKCD0.27754995
125SGK30.25767217
126RPS6KC10.23836539
127RPS6KL10.23836539
128ABL10.23523717
129CDK190.23372688
130TTN0.22750242
131CDK120.22038573

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.20749801
2B cell receptor signaling pathway_Homo sapiens_hsa046622.80674395
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.62304901
4DNA replication_Homo sapiens_hsa030302.51856767
5T cell receptor signaling pathway_Homo sapiens_hsa046602.51721650
6Antigen processing and presentation_Homo sapiens_hsa046122.45491889
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.42377747
8Leishmaniasis_Homo sapiens_hsa051402.36641829
9Measles_Homo sapiens_hsa051622.36517877
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.35565382
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30606898
12Hematopoietic cell lineage_Homo sapiens_hsa046402.19568440
13Osteoclast differentiation_Homo sapiens_hsa043802.01261550
14Mismatch repair_Homo sapiens_hsa034301.88665608
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84593268
16Ribosome_Homo sapiens_hsa030101.84221387
17Base excision repair_Homo sapiens_hsa034101.75668103
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74926816
19Allograft rejection_Homo sapiens_hsa053301.71326197
20Herpes simplex infection_Homo sapiens_hsa051681.68523670
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67075459
22Graft-versus-host disease_Homo sapiens_hsa053321.62964154
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56392534
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.54723668
25Shigellosis_Homo sapiens_hsa051311.52066207
26Viral myocarditis_Homo sapiens_hsa054161.41414204
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38291305
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.35221975
29Chemokine signaling pathway_Homo sapiens_hsa040621.32085753
30Acute myeloid leukemia_Homo sapiens_hsa052211.28343109
31Hepatitis B_Homo sapiens_hsa051611.27259907
32Non-homologous end-joining_Homo sapiens_hsa034501.24608326
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23750118
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23280381
35Influenza A_Homo sapiens_hsa051641.22041674
36Toxoplasmosis_Homo sapiens_hsa051451.21231717
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21209253
38Spliceosome_Homo sapiens_hsa030401.15112146
39Legionellosis_Homo sapiens_hsa051341.13147428
40Homologous recombination_Homo sapiens_hsa034401.12753079
41Apoptosis_Homo sapiens_hsa042101.11518496
42Epstein-Barr virus infection_Homo sapiens_hsa051691.07449793
43Platelet activation_Homo sapiens_hsa046111.07003171
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06505168
45* Phagosome_Homo sapiens_hsa041451.05083438
46Nucleotide excision repair_Homo sapiens_hsa034201.02510062
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02345474
48* Tuberculosis_Homo sapiens_hsa051521.00850991
49Asthma_Homo sapiens_hsa053100.99880250
50Pertussis_Homo sapiens_hsa051330.99648144
51Pancreatic cancer_Homo sapiens_hsa052120.97762142
52HTLV-I infection_Homo sapiens_hsa051660.95487519
53Autoimmune thyroid disease_Homo sapiens_hsa053200.94943401
54Chronic myeloid leukemia_Homo sapiens_hsa052200.90160557
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90059951
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89953684
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89086135
58Salmonella infection_Homo sapiens_hsa051320.88732721
59TNF signaling pathway_Homo sapiens_hsa046680.87760762
60Viral carcinogenesis_Homo sapiens_hsa052030.86394491
61Staphylococcus aureus infection_Homo sapiens_hsa051500.82149131
62Other glycan degradation_Homo sapiens_hsa005110.81502791
63Malaria_Homo sapiens_hsa051440.78357459
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.77378461
65Cell cycle_Homo sapiens_hsa041100.76902038
66Non-small cell lung cancer_Homo sapiens_hsa052230.76444204
67VEGF signaling pathway_Homo sapiens_hsa043700.74968742
68p53 signaling pathway_Homo sapiens_hsa041150.74122353
69Colorectal cancer_Homo sapiens_hsa052100.74008774
70Proteasome_Homo sapiens_hsa030500.73203369
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72297882
72Hepatitis C_Homo sapiens_hsa051600.68286565
73Type I diabetes mellitus_Homo sapiens_hsa049400.67385158
74Renal cell carcinoma_Homo sapiens_hsa052110.63623570
75Pyrimidine metabolism_Homo sapiens_hsa002400.63371531
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63032657
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62690756
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62664348
79RNA degradation_Homo sapiens_hsa030180.60124525
80Pentose phosphate pathway_Homo sapiens_hsa000300.59626537
81Fanconi anemia pathway_Homo sapiens_hsa034600.56482013
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.55016721
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52580005
84Choline metabolism in cancer_Homo sapiens_hsa052310.51670893
85Endometrial cancer_Homo sapiens_hsa052130.51135868
86Prolactin signaling pathway_Homo sapiens_hsa049170.50976982
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49639204
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.47935353
89RNA transport_Homo sapiens_hsa030130.47578293
90GnRH signaling pathway_Homo sapiens_hsa049120.43019617
91MAPK signaling pathway_Homo sapiens_hsa040100.41988920
92Endocytosis_Homo sapiens_hsa041440.41843762
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40569926
94mTOR signaling pathway_Homo sapiens_hsa041500.40396835
95Small cell lung cancer_Homo sapiens_hsa052220.37873454
96Systemic lupus erythematosus_Homo sapiens_hsa053220.37613416
97Caffeine metabolism_Homo sapiens_hsa002320.37607447
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.36334154
99Insulin resistance_Homo sapiens_hsa049310.35452543
100Notch signaling pathway_Homo sapiens_hsa043300.35387859
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.34487438
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.33594376
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32579638
104Thyroid cancer_Homo sapiens_hsa052160.32178208
105African trypanosomiasis_Homo sapiens_hsa051430.31677402
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31621279
107N-Glycan biosynthesis_Homo sapiens_hsa005100.31322822
108Rap1 signaling pathway_Homo sapiens_hsa040150.31255077
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31018614
110HIF-1 signaling pathway_Homo sapiens_hsa040660.30730715
111Regulation of autophagy_Homo sapiens_hsa041400.30713012
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30525201
113Type II diabetes mellitus_Homo sapiens_hsa049300.29822674
114Rheumatoid arthritis_Homo sapiens_hsa053230.29564727
115Prostate cancer_Homo sapiens_hsa052150.29548585
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28763622
117RNA polymerase_Homo sapiens_hsa030200.28577419
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28573940
119mRNA surveillance pathway_Homo sapiens_hsa030150.28535052
120Lysosome_Homo sapiens_hsa041420.27531723
121Dorso-ventral axis formation_Homo sapiens_hsa043200.26284827
122ErbB signaling pathway_Homo sapiens_hsa040120.25624295
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25419433
124Long-term potentiation_Homo sapiens_hsa047200.24719244
125Inositol phosphate metabolism_Homo sapiens_hsa005620.23806699
126FoxO signaling pathway_Homo sapiens_hsa040680.23686763

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