COQ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid metabolic process (GO:0072350)4.86591359
2lysine metabolic process (GO:0006553)4.80384509
3lysine catabolic process (GO:0006554)4.80384509
4valine metabolic process (GO:0006573)4.68766753
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.63669812
62-oxoglutarate metabolic process (GO:0006103)4.61981189
7establishment of integrated proviral latency (GO:0075713)4.46783778
8platelet dense granule organization (GO:0060155)4.40356661
9NADH metabolic process (GO:0006734)4.39863702
10DNA strand elongation involved in DNA replication (GO:0006271)4.38563104
11phospholipid scrambling (GO:0017121)4.38537237
12tricarboxylic acid cycle (GO:0006099)4.33720964
13oxaloacetate metabolic process (GO:0006107)4.31265285
14DNA strand elongation (GO:0022616)4.28151494
15short-chain fatty acid metabolic process (GO:0046459)4.26370887
16telomere maintenance via semi-conservative replication (GO:0032201)4.21269759
17DNA unwinding involved in DNA replication (GO:0006268)4.19725254
18carnitine shuttle (GO:0006853)4.03130230
19response to mercury ion (GO:0046689)4.02638059
20fatty acid beta-oxidation (GO:0006635)4.01766312
21aspartate family amino acid catabolic process (GO:0009068)3.99426081
22establishment of viral latency (GO:0019043)3.99051183
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95345087
24L-phenylalanine metabolic process (GO:0006558)3.95345087
25succinate metabolic process (GO:0006105)3.93891831
26ethanol oxidation (GO:0006069)3.90091405
27pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.86313942
28ribosomal small subunit assembly (GO:0000028)3.84027567
29fatty acid catabolic process (GO:0009062)3.82449139
30nucleobase-containing small molecule interconversion (GO:0015949)3.80609404
31deoxyribonucleotide biosynthetic process (GO:0009263)3.79110299
32fatty acid oxidation (GO:0019395)3.77725780
33branched-chain amino acid metabolic process (GO:0009081)3.75356359
34oxidative phosphorylation (GO:0006119)3.74293300
35branched-chain amino acid catabolic process (GO:0009083)3.73685483
362-deoxyribonucleotide biosynthetic process (GO:0009265)3.73425226
37deoxyribose phosphate biosynthetic process (GO:0046385)3.73425226
38fatty acid transmembrane transport (GO:1902001)3.71556351
39lipid oxidation (GO:0034440)3.67762033
40L-phenylalanine catabolic process (GO:0006559)3.65048920
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65048920
42protein localization to chromosome, centromeric region (GO:0071459)3.63944661
43mitotic chromosome condensation (GO:0007076)3.58083244
44CENP-A containing nucleosome assembly (GO:0034080)3.56397965
45telomere maintenance via recombination (GO:0000722)3.52641770
46DNA deamination (GO:0045006)3.51954666
47mitotic metaphase plate congression (GO:0007080)3.51943403
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51262521
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.50729386
50cysteine metabolic process (GO:0006534)3.45522467
51regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.45209581
52chromatin remodeling at centromere (GO:0031055)3.44589152
53mitotic recombination (GO:0006312)3.43039398
54carnitine metabolic process (GO:0009437)3.42265390
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41823224
56monocarboxylic acid catabolic process (GO:0072329)3.38503246
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37836565
58negative regulation of ligase activity (GO:0051352)3.37836565
59ribosome assembly (GO:0042255)3.32724996
60regulation of fatty acid oxidation (GO:0046320)3.32213785
61amino-acid betaine metabolic process (GO:0006577)3.31754779
62carnitine transmembrane transport (GO:1902603)3.31651974
63carnitine transport (GO:0015879)3.31183925
64amino-acid betaine transport (GO:0015838)3.31183925
65viral transcription (GO:0019083)3.31160968
66respiratory electron transport chain (GO:0022904)3.28685940
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28301634
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28037559
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27604093
70regulation of mitochondrial translation (GO:0070129)3.27438799
71glyoxylate metabolic process (GO:0046487)3.26652286
72proteasome assembly (GO:0043248)3.26257349
73protein localization to kinetochore (GO:0034501)3.25998627
74electron transport chain (GO:0022900)3.23945864
75deoxyribose phosphate catabolic process (GO:0046386)3.21511869
76DNA ligation (GO:0006266)3.21492710
77purine nucleobase biosynthetic process (GO:0009113)3.19123387
78deoxyribonucleotide catabolic process (GO:0009264)3.16711591
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16482445
80mitotic sister chromatid segregation (GO:0000070)3.15013304
81acetyl-CoA metabolic process (GO:0006084)3.14266271
82translational termination (GO:0006415)3.14051148
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.10623062
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.08878531
85regulation of acyl-CoA biosynthetic process (GO:0050812)3.07592655
86quaternary ammonium group transport (GO:0015697)3.06683513
87purine-containing compound salvage (GO:0043101)3.04927869
88pentose-phosphate shunt (GO:0006098)3.04836596
89sulfur amino acid catabolic process (GO:0000098)3.02920647
90drug transmembrane transport (GO:0006855)3.02079671
91pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.00946201
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00273117
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00273117
94IMP biosynthetic process (GO:0006188)2.98847488
95aerobic respiration (GO:0009060)2.98752208
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98550863
97aromatic amino acid family catabolic process (GO:0009074)2.97794419
98regulation of oxidative phosphorylation (GO:0002082)2.97141075
99pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.96800993
100DNA replication initiation (GO:0006270)2.96694103
101IMP metabolic process (GO:0046040)2.95426328
102metaphase plate congression (GO:0051310)2.95035709
103regulation of cofactor metabolic process (GO:0051193)2.94725414
104regulation of coenzyme metabolic process (GO:0051196)2.94725414
105pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.94426192
106translational elongation (GO:0006414)2.93497570
107kynurenine metabolic process (GO:0070189)2.90261201
108negative regulation of chromosome segregation (GO:0051985)2.88636908
109purine deoxyribonucleotide catabolic process (GO:0009155)2.88161610
110SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88155307
111ethanol metabolic process (GO:0006067)2.87982519
112kinetochore organization (GO:0051383)2.86279662
113muscle organ morphogenesis (GO:0048644)2.85878184
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84845424
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84845424
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84845424
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.84845424
118negative regulation of sister chromatid segregation (GO:0033046)2.84845424
119pseudouridine synthesis (GO:0001522)2.84432804
120base-excision repair, AP site formation (GO:0006285)2.83920521
121purine nucleotide salvage (GO:0032261)2.82541383
122pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82420995
123cellular modified amino acid catabolic process (GO:0042219)2.82333141
124organic acid catabolic process (GO:0016054)2.82217703
125carboxylic acid catabolic process (GO:0046395)2.82217703
126creatine metabolic process (GO:0006600)2.81825482
127formation of translation preinitiation complex (GO:0001731)2.81452597
128protein targeting to ER (GO:0045047)2.81278338
129sister chromatid segregation (GO:0000819)2.80762236
130mitotic spindle assembly checkpoint (GO:0007094)2.80181000
131nucleobase biosynthetic process (GO:0046112)2.80025124
132cellular ketone body metabolic process (GO:0046950)2.79624734
133DNA replication-independent nucleosome organization (GO:0034724)2.79388474
134DNA replication-independent nucleosome assembly (GO:0006336)2.79388474
135cotranslational protein targeting to membrane (GO:0006613)2.79128201
136DNA replication checkpoint (GO:0000076)2.79056868
137regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78242488
138spindle assembly checkpoint (GO:0071173)2.77904598
139alpha-linolenic acid metabolic process (GO:0036109)2.77108188
140positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.76238249
141protein deneddylation (GO:0000338)2.76141082
142phosphate ion transport (GO:0006817)2.74994933
143NADPH regeneration (GO:0006740)2.74992046
144homocysteine metabolic process (GO:0050667)2.74912442
145ribosomal small subunit biogenesis (GO:0042274)2.74833692
146bile acid biosynthetic process (GO:0006699)2.74737248
147glutamate metabolic process (GO:0006536)2.74596201
148positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74168840
149folic acid metabolic process (GO:0046655)2.74121237
150transcription-coupled nucleotide-excision repair (GO:0006283)2.73878774
151nucleotide-excision repair, DNA gap filling (GO:0006297)2.73757396
152pyrimidine nucleotide catabolic process (GO:0006244)2.73421723
153establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73247304
154cullin deneddylation (GO:0010388)2.72508227
155cellular amino acid catabolic process (GO:0009063)2.72196948
156negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72148269
157telomere maintenance via telomere lengthening (GO:0010833)2.71458100
158negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.71213983
159protein localization to endoplasmic reticulum (GO:0070972)2.71210528
160deoxyribose phosphate metabolic process (GO:0019692)2.70883395
161base-excision repair (GO:0006284)2.70827817
162regulation of ubiquitin-protein transferase activity (GO:0051438)2.70570193
163alpha-amino acid catabolic process (GO:1901606)2.70049956
164deoxyribonucleotide metabolic process (GO:0009262)2.69586659
165regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69257609
166regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69257609
167positive regulation of ligase activity (GO:0051351)2.68868155
168establishment of chromosome localization (GO:0051303)2.68513568
169pinocytosis (GO:0006907)2.68250609
170iron-sulfur cluster assembly (GO:0016226)2.68173953
171metallo-sulfur cluster assembly (GO:0031163)2.68173953
172spindle checkpoint (GO:0031577)2.67577206
173mitochondrial calcium ion transport (GO:0006851)2.66970569
174cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66582764
175regulation of ligase activity (GO:0051340)2.66230295
176drug transport (GO:0015893)2.66017370
1774-hydroxyproline metabolic process (GO:0019471)2.65994600
178protein maturation by protein folding (GO:0022417)2.65346235
1792-deoxyribonucleotide metabolic process (GO:0009394)2.65101700
180guanosine-containing compound biosynthetic process (GO:1901070)2.64492069
181folic acid-containing compound biosynthetic process (GO:0009396)2.63652434
182regulation of sulfur metabolic process (GO:0042762)2.62671413
183nucleoside salvage (GO:0043174)2.62271274
184dicarboxylic acid metabolic process (GO:0043648)2.61113204
185regulation of chromosome segregation (GO:0051983)2.60627105
186gluconeogenesis (GO:0006094)2.60450289
187mitotic spindle checkpoint (GO:0071174)2.59697473
188flavonoid metabolic process (GO:0009812)2.59176446
189nucleotide salvage (GO:0043173)2.57724420
190energy coupled proton transport, down electrochemical gradient (GO:0015985)2.57683875
191ATP synthesis coupled proton transport (GO:0015986)2.57683875
192biotin metabolic process (GO:0006768)2.54699669
193primary alcohol catabolic process (GO:0034310)2.54255754
194positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.53112113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.75966308
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.51852592
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.09143368
4GATA1_22025678_ChIP-Seq_K562_Human4.30778341
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.76826468
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51851638
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.40954091
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.40259484
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21636105
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.20411858
11ZNF263_19887448_ChIP-Seq_K562_Human2.98433931
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.95575760
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94898364
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89785036
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83805790
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66738626
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.56210247
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51975852
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49447241
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.48340982
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.34482504
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33959948
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30869265
24AR_21909140_ChIP-Seq_LNCAP_Human2.29440155
25DCP1A_22483619_ChIP-Seq_HELA_Human2.28770601
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23718450
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22082572
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.15368788
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.12188110
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11741935
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09401667
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09350942
33SCL_19346495_ChIP-Seq_HPC-7_Human2.06378485
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04925991
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97654740
36XRN2_22483619_ChIP-Seq_HELA_Human1.95088224
37* MYC_18555785_ChIP-Seq_MESCs_Mouse1.90785244
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90018801
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87719074
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87125187
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84061569
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82055603
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81165433
44VDR_21846776_ChIP-Seq_THP-1_Human1.80498283
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.75687664
46GABP_19822575_ChIP-Seq_HepG2_Human1.75632949
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75462985
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75402783
49FOXP3_21729870_ChIP-Seq_TREG_Human1.71690231
50LXR_22292898_ChIP-Seq_THP-1_Human1.71270168
51* VDR_23849224_ChIP-Seq_CD4+_Human1.70995539
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68190687
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60557120
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59032871
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.56251279
56TTF2_22483619_ChIP-Seq_HELA_Human1.56096231
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54634604
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53559489
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53476772
60ELK1_19687146_ChIP-ChIP_HELA_Human1.53023961
61TFEB_21752829_ChIP-Seq_HELA_Human1.52080556
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50707809
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50485552
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48708356
65MYC_22102868_ChIP-Seq_BL_Human1.48513128
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.47084338
67BCL6_27268052_Chip-Seq_Bcells_Human1.45807488
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.45007271
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44404410
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41456976
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38215533
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36383597
73P68_20966046_ChIP-Seq_HELA_Human1.36351325
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35245300
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34246234
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33349168
77* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33128939
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32820333
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32745520
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32554889
81* ELF1_20517297_ChIP-Seq_JURKAT_Human1.32400679
82* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.32220117
83BCOR_27268052_Chip-Seq_Bcells_Human1.31894804
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29452665
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29447689
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.29414807
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28160303
88MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27764024
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26914049
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26570044
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26449750
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26335370
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23944600
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23439355
95KDM5A_27292631_Chip-Seq_BREAST_Human1.23270035
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21507091
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20988543
98SPI1_23547873_ChIP-Seq_NB4_Human1.19676177
99* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19579047
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19155555
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18639222
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17955249
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16907883
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16889901
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16323806
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.14230166
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12070173
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12058457
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.11135301
110* TCF7_22412390_ChIP-Seq_EML_Mouse1.09876109
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09485430
112P300_27268052_Chip-Seq_Bcells_Human1.09339562
113* CTCF_26484167_Chip-Seq_Bcells_Mouse1.09179835
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08990678
115RACK7_27058665_Chip-Seq_MCF-7_Human1.08825914
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08216744
117SA1_27219007_Chip-Seq_Bcells_Human1.07336874
118* CTCF_21964334_Chip-Seq_Bcells_Human1.07224575
119GATA1_19941826_ChIP-Seq_K562_Human1.05826090
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05331936
121* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03812844
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03641333
123* VDR_24763502_ChIP-Seq_THP-1_Human1.03012214
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03005744
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02806031
126SA1_27219007_Chip-Seq_ERYTHROID_Human1.01758027
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01732854
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98800663
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.97976596
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97767659
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97739993
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.97295637
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.96824048
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96192051
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95973686
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95273008
137NOTCH1_21737748_ChIP-Seq_TLL_Human0.95122098
138MAF_26560356_Chip-Seq_TH1_Human0.94693015
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93997088
140CLOCK_20551151_ChIP-Seq_293T_Human0.92590367
141ETS1_21867929_ChIP-Seq_TH2_Mouse0.92018212
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.92012244
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.92012244
144CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91648671
145* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91304299
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91210635
147SMC4_20622854_ChIP-Seq_HELA_Human0.90888774
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89237622
149* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89011119
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88954170
151TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87954095
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87700399
153STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87610758
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87571657
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87124761
156CIITA_25753668_ChIP-Seq_RAJI_Human0.86908665
157NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86900993
158* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86336062
159* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86106768
160* ATF3_27146783_Chip-Seq_COLON_Human0.85803211
161IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84842712
162KDM2B_26808549_Chip-Seq_DND41_Human0.84726404
163* RUNX1_22412390_ChIP-Seq_EML_Mouse0.84666101
164NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84629470
165POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84519291
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83738884
167* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83423390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.95445365
2MP0002139_abnormal_hepatobiliary_system3.68964330
3MP0005360_urolithiasis3.67015177
4MP0003111_abnormal_nucleus_morphology3.65926182
5MP0003693_abnormal_embryo_hatching3.51758480
6MP0005365_abnormal_bile_salt3.50144444
7MP0002837_dystrophic_cardiac_calcinosis3.40060580
8MP0005085_abnormal_gallbladder_physiolo3.23910040
9MP0004957_abnormal_blastocyst_morpholog3.20781151
10MP0002877_abnormal_melanocyte_morpholog3.00175305
11MP0008058_abnormal_DNA_repair2.97100259
12MP0003646_muscle_fatigue2.96674544
13MP0008057_abnormal_DNA_replication2.92656750
14MP0003077_abnormal_cell_cycle2.86255056
15MP0006036_abnormal_mitochondrial_physio2.85582244
16MP0003806_abnormal_nucleotide_metabolis2.68419994
17MP0000751_myopathy2.64810876
18MP0008875_abnormal_xenobiotic_pharmacok2.47430463
19MP0004130_abnormal_muscle_cell2.44636109
20MP0008932_abnormal_embryonic_tissue2.34614299
21MP0000749_muscle_degeneration2.34573108
22MP0008007_abnormal_cellular_replicative2.28922422
23MP0003252_abnormal_bile_duct2.23241991
24MP0005330_cardiomyopathy2.22516939
25MP0004147_increased_porphyrin_level2.18765143
26MP0010329_abnormal_lipoprotein_level2.15895365
27MP0004215_abnormal_myocardial_fiber2.15421548
28MP0005083_abnormal_biliary_tract2.09767523
29MP0001666_abnormal_nutrient_absorption2.00677423
30MP0005332_abnormal_amino_acid2.00024652
31MP0005058_abnormal_lysosome_morphology1.95306967
32MP0005584_abnormal_enzyme/coenzyme_acti1.94130158
33MP0000747_muscle_weakness1.87970289
34MP0004145_abnormal_muscle_electrophysio1.84506844
35MP0005451_abnormal_body_composition1.78171019
36MP0004043_abnormal_pH_regulation1.76033200
37MP0008961_abnormal_basal_metabolism1.73385583
38MP0003786_premature_aging1.70144813
39MP0004036_abnormal_muscle_relaxation1.69026800
40MP0001873_stomach_inflammation1.68553660
41MP0004084_abnormal_cardiac_muscle1.62713173
42MP0002118_abnormal_lipid_homeostasis1.61152793
43MP0002269_muscular_atrophy1.54592434
44MP0005535_abnormal_body_temperature1.53070627
45MP0000350_abnormal_cell_proliferation1.52772820
46MP0005319_abnormal_enzyme/_coenzyme1.51171358
47MP0006035_abnormal_mitochondrial_morpho1.50771399
48MP0002332_abnormal_exercise_endurance1.48934255
49MP0009643_abnormal_urine_homeostasis1.48906752
50MP0005266_abnormal_metabolism1.45679008
51MP0004859_abnormal_synaptic_plasticity1.44685531
52MP0008260_abnormal_autophagy1.43764689
53MP0004087_abnormal_muscle_fiber1.42251275
54MP0003868_abnormal_feces_composition1.42210961
55MP0000750_abnormal_muscle_regeneration1.41229517
56MP0000313_abnormal_cell_death1.40707060
57MP0010307_abnormal_tumor_latency1.39357803
58MP0005220_abnormal_exocrine_pancreas1.38542140
59MP0001730_embryonic_growth_arrest1.37493251
60MP0002909_abnormal_adrenal_gland1.35568749
61MP0005666_abnormal_adipose_tissue1.35429268
62MP0003221_abnormal_cardiomyocyte_apopto1.35237389
63MP0001853_heart_inflammation1.34824887
64MP0002078_abnormal_glucose_homeostasis1.34343313
65MP0005636_abnormal_mineral_homeostasis1.34160531
66MP0005501_abnormal_skin_physiology1.32420740
67MP0001765_abnormal_ion_homeostasis1.31186991
68MP0000609_abnormal_liver_physiology1.30439097
69MP0005620_abnormal_muscle_contractility1.29152984
70MP0001764_abnormal_homeostasis1.27081717
71MP0002138_abnormal_hepatobiliary_system1.26067087
72MP0001835_abnormal_antigen_presentation1.24908471
73MP0000490_abnormal_crypts_of1.24754086
74MP0000465_gastrointestinal_hemorrhage1.24292393
75MP0009333_abnormal_splenocyte_physiolog1.23028118
76MP0002019_abnormal_tumor_incidence1.22317699
77MP0000358_abnormal_cell_content/1.22168398
78MP0004808_abnormal_hematopoietic_stem1.21644585
79MP0009840_abnormal_foam_cell1.21124180
80MP0003191_abnormal_cellular_cholesterol1.20330551
81MP0003186_abnormal_redox_activity1.19480263
82MP0001727_abnormal_embryo_implantation1.19213431
83MP0009278_abnormal_bone_marrow1.17793356
84MP0009379_abnormal_foot_pigmentation1.16639965
85MP0010352_gastrointestinal_tract_polyps1.14053933
86MP0002822_catalepsy1.13955468
87MP0001348_abnormal_lacrimal_gland1.13040372
88MP0003718_maternal_effect1.11662663
89MP0003195_calcinosis1.10908933
90MP0003656_abnormal_erythrocyte_physiolo1.10862935
91MP0004484_altered_response_of1.10693907
92MP0009697_abnormal_copulation1.10599867
93MP0008872_abnormal_physiological_respon1.10020113
94MP0002971_abnormal_brown_adipose1.10015130
95MP0005375_adipose_tissue_phenotype1.09885561
96MP0000343_altered_response_to1.09162570
97MP0002396_abnormal_hematopoietic_system1.09156851
98MP0005165_increased_susceptibility_to1.08784764
99MP0003315_abnormal_perineum_morphology1.08642233
100MP0001545_abnormal_hematopoietic_system1.08348588
101MP0005397_hematopoietic_system_phenotyp1.08348588
102MP0005084_abnormal_gallbladder_morpholo1.08108094
103MP0001661_extended_life_span1.07987028
104MP0002106_abnormal_muscle_physiology1.05100187
105MP0004510_myositis1.04855144
106MP0000013_abnormal_adipose_tissue1.04551356
107MP0001697_abnormal_embryo_size1.04421407
108MP0010234_abnormal_vibrissa_follicle1.04203957
109MP0002796_impaired_skin_barrier1.03987112
110MP0002148_abnormal_hypersensitivity_rea1.03819475
111MP0000858_altered_metastatic_potential1.03144214
112MP0010630_abnormal_cardiac_muscle1.03084501
113MP0002080_prenatal_lethality1.02588732
114MP0002972_abnormal_cardiac_muscle1.00026998
115MP0003828_pulmonary_edema0.99672054
116MP0008775_abnormal_heart_ventricle0.97662439
117MP0008874_decreased_physiological_sensi0.97569638
118MP0005076_abnormal_cell_differentiation0.96557050
119MP0005670_abnormal_white_adipose0.96494604
120MP0001881_abnormal_mammary_gland0.96359819
121MP0001672_abnormal_embryogenesis/_devel0.96323093
122MP0005380_embryogenesis_phenotype0.96323093
123MP0003436_decreased_susceptibility_to0.96318309
124MP0001944_abnormal_pancreas_morphology0.95089841
125MP0003941_abnormal_skin_development0.93684434
126MP0005334_abnormal_fat_pad0.93012830
127MP0000759_abnormal_skeletal_muscle0.92932599
128MP0003075_altered_response_to0.92661418
129MP0003137_abnormal_impulse_conducting0.92318585
130MP0000003_abnormal_adipose_tissue0.90943111
131MP0002693_abnormal_pancreas_physiology0.89833292
132MP0003984_embryonic_growth_retardation0.89634538
133MP0009765_abnormal_xenobiotic_induced0.89177539
134MP0000230_abnormal_systemic_arterial0.88001760
135MP0002419_abnormal_innate_immunity0.85381966
136MP0002722_abnormal_immune_system0.84967094
137MP0005464_abnormal_platelet_physiology0.84133475
138MP0005385_cardiovascular_system_phenoty0.84030127
139MP0001544_abnormal_cardiovascular_syste0.84030127
140MP0002088_abnormal_embryonic_growth/wei0.83811519
141MP0000689_abnormal_spleen_morphology0.82749842
142MP0009642_abnormal_blood_homeostasis0.82609246
143MP0004233_abnormal_muscle_weight0.81885941
144MP0005376_homeostasis/metabolism_phenot0.81548989
145MP0005448_abnormal_energy_balance0.80144486
146MP0003566_abnormal_cell_adhesion0.80096989
147MP0002970_abnormal_white_adipose0.79880770
148MP0001663_abnormal_digestive_system0.79720792
149MP0005384_cellular_phenotype0.78766779
150MP0003959_abnormal_lean_body0.77810018
151MP0005621_abnormal_cell_physiology0.77362252
152MP0009764_decreased_sensitivity_to0.76135841
153MP0003879_abnormal_hair_cell0.75963464
154MP0002166_altered_tumor_susceptibility0.75693350
155MP0002398_abnormal_bone_marrow0.73179107
156MP0001542_abnormal_bone_strength0.73124928
157MP0004185_abnormal_adipocyte_glucose0.72455677
158MP0002429_abnormal_blood_cell0.72358289
159MP0009763_increased_sensitivity_to0.72026593
160MP0005369_muscle_phenotype0.71367927
161MP0008469_abnormal_protein_level0.69102608
162MP0001243_abnormal_dermal_layer0.67642485
163MP0002452_abnormal_antigen_presenting0.66777716
164MP0000015_abnormal_ear_pigmentation0.66711774
165MP0003705_abnormal_hypodermis_morpholog0.66200706
166MP0005025_abnormal_response_to0.65980322
167MP0003303_peritoneal_inflammation0.65240535
168MP0002009_preneoplasia0.65082122
169MP0001191_abnormal_skin_condition0.64752419
170MP0000569_abnormal_digit_pigmentation0.64723627
171MP0004197_abnormal_fetal_growth/weight/0.64608412

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.54017221
2Muscle fiber inclusion bodies (HP:0100299)4.18550964
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.09595963
4Ketoacidosis (HP:0001993)3.80753717
5* Myoglobinuria (HP:0002913)3.77699435
6Ketosis (HP:0001946)3.73783666
7Hypoglycemic coma (HP:0001325)3.68486247
8Hepatic necrosis (HP:0002605)3.57932900
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55761472
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.52779302
11Abnormality of alanine metabolism (HP:0010916)3.52779302
12Hyperalaninemia (HP:0003348)3.52779302
13Reduced antithrombin III activity (HP:0001976)3.33642437
14Exercise-induced myalgia (HP:0003738)3.26322314
15Abnormality of fatty-acid metabolism (HP:0004359)3.25027847
16Hyperammonemia (HP:0001987)3.22962244
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20708510
18Dicarboxylic aciduria (HP:0003215)3.20708510
19Hepatocellular necrosis (HP:0001404)3.16636556
20Type I transferrin isoform profile (HP:0003642)3.10237076
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.07099504
22Acute encephalopathy (HP:0006846)3.01799157
23Increased muscle lipid content (HP:0009058)2.99594611
24Abnormality of cells of the erythroid lineage (HP:0012130)2.99528221
25Abnormal number of erythroid precursors (HP:0012131)2.98313643
26Microvesicular hepatic steatosis (HP:0001414)2.97507131
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93393212
28Abnormal mitochondria in muscle tissue (HP:0008316)2.93293827
29Calf muscle hypertrophy (HP:0008981)2.91711325
30Abnormal protein glycosylation (HP:0012346)2.91154347
31Abnormal glycosylation (HP:0012345)2.91154347
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.91154347
33Abnormal protein N-linked glycosylation (HP:0012347)2.91154347
34Dry hair (HP:0011359)2.87751628
35Cerebral edema (HP:0002181)2.86422129
36Prostate neoplasm (HP:0100787)2.86229054
37Palpitations (HP:0001962)2.81327030
38Rhabdomyolysis (HP:0003201)2.77549814
39Acute necrotizing encephalopathy (HP:0006965)2.76494629
40* Lactic acidosis (HP:0003128)2.74849614
41Hyperglycinuria (HP:0003108)2.74435122
42Generalized aminoaciduria (HP:0002909)2.74028022
43Muscle hypertrophy of the lower extremities (HP:0008968)2.73342957
44Rough bone trabeculation (HP:0100670)2.73094235
45* Ragged-red muscle fibers (HP:0003200)2.71967205
46Abnormality of serine family amino acid metabolism (HP:0010894)2.70195301
47Abnormality of glycine metabolism (HP:0010895)2.70195301
48Selective tooth agenesis (HP:0001592)2.69935174
49Sudden death (HP:0001699)2.69722883
50Hepatosplenomegaly (HP:0001433)2.69255195
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.67619079
52Exercise-induced muscle cramps (HP:0003710)2.67291975
53Asymmetric septal hypertrophy (HP:0001670)2.65155831
54Metabolic acidosis (HP:0001942)2.64021163
55Atrioventricular block (HP:0001678)2.62858243
56Increased intramyocellular lipid droplets (HP:0012240)2.60187715
57Increased CSF lactate (HP:0002490)2.59590834
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59297841
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59297841
60Multiple enchondromatosis (HP:0005701)2.58882494
61Late onset (HP:0003584)2.57385588
62Increased serum pyruvate (HP:0003542)2.56260787
63Petechiae (HP:0000967)2.55679434
64Mitochondrial inheritance (HP:0001427)2.52794290
65Delayed CNS myelination (HP:0002188)2.51529348
66Rimmed vacuoles (HP:0003805)2.51059288
67Bundle branch block (HP:0011710)2.50911559
68Nasal polyposis (HP:0100582)2.50888119
69Gout (HP:0001997)2.50510327
70Myopathic facies (HP:0002058)2.49877011
71Xanthomatosis (HP:0000991)2.44746074
72Ventricular tachycardia (HP:0004756)2.43466159
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42685463
74Degeneration of anterior horn cells (HP:0002398)2.41711520
75Abnormality of the anterior horn cell (HP:0006802)2.41711520
76Hyperglycinemia (HP:0002154)2.41133890
77Neck muscle weakness (HP:0000467)2.40691794
78Intrahepatic cholestasis (HP:0001406)2.40574144
79Hyperlipoproteinemia (HP:0010980)2.38772248
80Heart block (HP:0012722)2.37102828
81Abnormality of the nasal mucosa (HP:0000433)2.34787186
82Thrombocytosis (HP:0001894)2.32699793
83Increased serum lactate (HP:0002151)2.30708693
84Aplastic anemia (HP:0001915)2.29448487
85Abnormality of glycolysis (HP:0004366)2.24915969
86Lethargy (HP:0001254)2.23511418
87Distal lower limb muscle weakness (HP:0009053)2.23205862
88Reduced subcutaneous adipose tissue (HP:0003758)2.22535518
89Right ventricular cardiomyopathy (HP:0011663)2.20645572
90Abnormality of the prostate (HP:0008775)2.19294547
91Progressive macrocephaly (HP:0004481)2.15973771
92Myotonia (HP:0002486)2.14374335
93Hypokinesia (HP:0002375)2.13797967
94Abnormality of serum amino acid levels (HP:0003112)2.13479779
95Hyperbilirubinemia (HP:0002904)2.13195429
96Abnormality of the umbilical cord (HP:0010881)2.13090754
97* Progressive muscle weakness (HP:0003323)2.12047817
98Abnormal atrioventricular conduction (HP:0005150)2.11452020
99Supraventricular tachycardia (HP:0004755)2.10200231
100Vomiting (HP:0002013)2.10090589
101Abnormal trabecular bone morphology (HP:0100671)2.08656776
102Atrial fibrillation (HP:0005110)2.07318473
103Type II lissencephaly (HP:0007260)2.07022775
104* Pancytopenia (HP:0001876)2.05128042
105Chromsome breakage (HP:0040012)2.04726792
106Supraventricular arrhythmia (HP:0005115)2.04067231
107Methylmalonic aciduria (HP:0012120)2.03903658
108Pelvic girdle muscle weakness (HP:0003749)2.03617832
109Ridged nail (HP:0001807)2.03239030
110Recurrent bacterial skin infections (HP:0005406)2.03113195
111Recurrent abscess formation (HP:0002722)2.01075610
112Abnormality of glycolipid metabolism (HP:0010969)2.00491645
113Abnormality of liposaccharide metabolism (HP:0010968)2.00491645
114Abnormality of glycosphingolipid metabolism (HP:0004343)2.00491645
115Shoulder girdle muscle weakness (HP:0003547)1.99331615
116Primary atrial arrhythmia (HP:0001692)1.98899297
117EMG: myopathic abnormalities (HP:0003458)1.98537340
118Lipoatrophy (HP:0100578)1.97472328
119Limb-girdle muscle atrophy (HP:0003797)1.96959498
120Fatigue (HP:0012378)1.96546343
121Deep venous thrombosis (HP:0002625)1.96167526
122Hyperinsulinemic hypoglycemia (HP:0000825)1.95781168
123Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95369323
124Abnormality of the intrinsic pathway (HP:0010989)1.95206727
125Nausea (HP:0002018)1.94963761
126Neoplasm of the adrenal gland (HP:0100631)1.94582455
127Abnormality of the heme biosynthetic pathway (HP:0010472)1.94060039
128Cortical dysplasia (HP:0002539)1.92837487
129Proximal tubulopathy (HP:0000114)1.92702365
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92429365
131Sparse eyelashes (HP:0000653)1.91635159
132Exercise intolerance (HP:0003546)1.91040930
133Hypobetalipoproteinemia (HP:0003563)1.90048917
134Dilated cardiomyopathy (HP:0001644)1.88408587
135Prolonged partial thromboplastin time (HP:0003645)1.88027992
136Subaortic stenosis (HP:0001682)1.88005640
137Abnormality of the left ventricular outflow tract (HP:0011103)1.88005640
138Abnormal platelet function (HP:0011869)1.87842541
139Impaired platelet aggregation (HP:0003540)1.87842541
140Increased hepatocellular lipid droplets (HP:0006565)1.87600601
141Neoplasm of head and neck (HP:0012288)1.86008021
142Esophageal neoplasm (HP:0100751)1.86008021
143Lipid accumulation in hepatocytes (HP:0006561)1.85798225
144Abnormality of purine metabolism (HP:0004352)1.85401977
145Muscle stiffness (HP:0003552)1.84233694
146Syncope (HP:0001279)1.84064567
147Paralysis (HP:0003470)1.83753152
148Fasciculations (HP:0002380)1.83138452
149Abnormalities of placenta or umbilical cord (HP:0001194)1.81796017
150Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80720747
151Respiratory failure (HP:0002878)1.79770618
152Ventricular arrhythmia (HP:0004308)1.78511900
153Pancreatitis (HP:0001733)1.76799061
154Orthostatic hypotension (HP:0001278)1.76109673
155Increased serum ferritin (HP:0003281)1.75980799
156Abnormality of the calf musculature (HP:0001430)1.75844321
157Hyperuricemia (HP:0002149)1.75712992
158Increased purine levels (HP:0004368)1.75712992
159Sensorimotor neuropathy (HP:0007141)1.75054620
160Calcaneovalgus deformity (HP:0001848)1.74079676
161Microretrognathia (HP:0000308)1.72817522
162Gliosis (HP:0002171)1.72522963
163Abnormality of the preputium (HP:0100587)1.72361990
164Entropion (HP:0000621)1.70181297
165Vertebral compression fractures (HP:0002953)1.69631302
166Upper motor neuron abnormality (HP:0002127)1.69331982
167Myelodysplasia (HP:0002863)1.66778316
168Type 1 muscle fiber predominance (HP:0003803)1.63502146
169Abnormality of lateral ventricle (HP:0030047)1.63491899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.54659774
2BUB14.20911182
3CDC73.39907872
4PKN23.17345235
5TESK23.17021415
6PINK13.04122908
7SRPK12.96104575
8VRK22.94337555
9TRIB32.84363455
10PBK2.81251457
11TTK2.40929411
12PDK22.40142109
13IRAK32.38637050
14ERN12.27313164
15EIF2AK12.04296270
16NME22.04027512
17MAP2K32.00184625
18TTN1.89463724
19MUSK1.88382782
20PLK41.87182197
21FLT31.78344469
22MAP3K71.77144643
23CCNB11.74917567
24MAP3K121.72174210
25TNIK1.70522878
26EEF2K1.67194456
27LMTK21.66121981
28MYLK1.65772971
29ARAF1.63555391
30KSR21.61809181
31CDK191.58827999
32PDK41.58552523
33PDK31.58552523
34MAP3K131.57438013
35MAPKAPK31.54100836
36NEK11.53775592
37CAMKK21.44690754
38TIE11.43691496
39RPS6KA41.43374712
40STK161.43004282
41PHKG11.39522461
42PHKG21.39522461
43RAF11.38303045
44PLK11.37610119
45RIPK11.34426907
46TESK11.30066386
47OBSCN1.28049122
48PAK41.21687070
49VRK11.19927897
50LIMK11.19845454
51PIM21.19183296
52ABL21.18271868
53STK101.17579871
54DAPK11.16796869
55AURKA1.13805625
56AURKB1.13244989
57MAP2K61.10822544
58MATK1.10536665
59CAMKK11.09971631
60CAMK11.08637184
61STK41.08124241
62PRKCH1.07931416
63MAP3K11.06264165
64CDK71.06013750
65INSRR1.05907144
66NTRK31.05730881
67MAP3K81.04078686
68CHEK21.03746906
69WEE10.97844485
70CDK80.97065060
71SCYL20.96751267
72FGFR40.95988902
73MAP3K140.94766194
74ATR0.94300298
75TAOK10.94248932
76LRRK20.93148358
77PLK30.92775184
78BTK0.92581181
79MAP4K10.89335868
80MST1R0.86758769
81DAPK20.86755713
82MST40.85770836
83MAP3K90.85575683
84TSSK60.84601608
85EPHA40.84476633
86MAP2K40.84405099
87SIK10.80590284
88EIF2AK30.79412035
89TGFBR20.79142041
90MAP3K50.78965864
91BMPR20.78765060
92WNK40.78680686
93KIT0.78312008
94RPS6KB20.78207826
95PDK10.78195996
96MAPK110.78076062
97MAP3K110.77718958
98MOS0.76385184
99BRAF0.76383736
100TEC0.75367563
101CDK60.74107465
102TNK20.74000109
103PRKD30.72560385
104KSR10.71202580
105CDK40.70530578
106EIF2AK20.70406144
107PIK3CG0.69963130
108DYRK30.68342328
109ACVR1B0.68010037
110RET0.67730584
111NEK90.66898621
112CSNK1G30.66736410
113DAPK30.65395245
114JAK20.65231291
115SMG10.64202123
116HIPK20.64106988
117ZAK0.62124699
118BRSK20.60619130
119MAPKAPK50.60509008
120IRAK20.60421174
121CLK10.58616788
122MAP2K20.58142112
123ERBB30.57974290
124BRSK10.57919559
125MAP3K30.57433113
126BLK0.56865515
127TGFBR10.56801927
128NEK20.55777655
129TYK20.54269946
130MAP3K20.54230275
131IRAK40.53854291
132ILK0.53741321
133CHEK10.53519727
134PRKAA20.52029206
135FES0.51492477
136JAK30.51081552
137MAPK40.50748837
138TBK10.50460014
139SYK0.50094668
140PAK10.49547934
141CDK140.47430216
142CAMK2G0.46258582
143CSNK2A10.45521905
144PDPK10.44871842
145PASK0.44313638
146CSNK1G10.43993866
147AKT20.43099295
148TAOK20.42703840
149CDK90.41978242
150CSNK1A1L0.41800614
151MAP2K10.40825605
152CSNK2A20.39496623
153PRKD10.39131896
154CAMK40.38823344
155NME10.37240729
156CSF1R0.36369276
157IKBKB0.35979428
158PRKACG0.35970805
159CDK50.35645547
160CDK150.35640554
161IKBKE0.34809162
162STK380.34731396
163RPS6KA50.34725266
164KDR0.34271376
165ATM0.33948017
166GRK60.33493624
167CDK11A0.33002590
168CDK180.32372062
169PRPF4B0.32316860

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.18168729
2Proteasome_Homo sapiens_hsa030503.60873984
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.45635759
4Base excision repair_Homo sapiens_hsa034103.39249001
5Fatty acid degradation_Homo sapiens_hsa000713.30029832
6Propanoate metabolism_Homo sapiens_hsa006403.24729755
7Mismatch repair_Homo sapiens_hsa034303.23713064
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.13901326
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81011984
10Nitrogen metabolism_Homo sapiens_hsa009102.76287071
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64990305
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.34167264
13Pyrimidine metabolism_Homo sapiens_hsa002402.33961704
14Carbon metabolism_Homo sapiens_hsa012002.25134617
15Nucleotide excision repair_Homo sapiens_hsa034202.16276425
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15309138
17Pyruvate metabolism_Homo sapiens_hsa006202.12840183
18Spliceosome_Homo sapiens_hsa030402.10961670
19Tryptophan metabolism_Homo sapiens_hsa003802.04034462
20Homologous recombination_Homo sapiens_hsa034401.99952486
21Fatty acid metabolism_Homo sapiens_hsa012121.96729278
22Non-homologous end-joining_Homo sapiens_hsa034501.94898864
23Parkinsons disease_Homo sapiens_hsa050121.89664538
24RNA polymerase_Homo sapiens_hsa030201.88625356
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88497187
26Ribosome_Homo sapiens_hsa030101.86865824
27Cell cycle_Homo sapiens_hsa041101.86167500
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77053688
29Arginine biosynthesis_Homo sapiens_hsa002201.76046487
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75062826
31Peroxisome_Homo sapiens_hsa041461.72642735
32Fanconi anemia pathway_Homo sapiens_hsa034601.69698031
33Butanoate metabolism_Homo sapiens_hsa006501.68587434
34Oxidative phosphorylation_Homo sapiens_hsa001901.62574609
35beta-Alanine metabolism_Homo sapiens_hsa004101.57517270
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56231830
37Biosynthesis of amino acids_Homo sapiens_hsa012301.54996403
38RNA transport_Homo sapiens_hsa030131.52374149
39Sulfur metabolism_Homo sapiens_hsa009201.51455082
40One carbon pool by folate_Homo sapiens_hsa006701.49355345
41PPAR signaling pathway_Homo sapiens_hsa033201.46314113
42Cardiac muscle contraction_Homo sapiens_hsa042601.42056587
43Sulfur relay system_Homo sapiens_hsa041221.40862914
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38730528
45Folate biosynthesis_Homo sapiens_hsa007901.33312371
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25960056
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24290027
48Alzheimers disease_Homo sapiens_hsa050101.22934084
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19606075
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19183180
51Starch and sucrose metabolism_Homo sapiens_hsa005001.18600496
52Purine metabolism_Homo sapiens_hsa002301.16946347
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16566366
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.14070502
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13521342
56Selenocompound metabolism_Homo sapiens_hsa004501.11137526
57ABC transporters_Homo sapiens_hsa020101.11104799
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08517920
59Bile secretion_Homo sapiens_hsa049761.06724956
60Caffeine metabolism_Homo sapiens_hsa002321.03946356
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.02900005
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00884872
63Fatty acid elongation_Homo sapiens_hsa000620.98909522
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97081592
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.94117048
66Fat digestion and absorption_Homo sapiens_hsa049750.93515450
67Phenylalanine metabolism_Homo sapiens_hsa003600.93260153
68Pentose phosphate pathway_Homo sapiens_hsa000300.93260012
69Systemic lupus erythematosus_Homo sapiens_hsa053220.92621200
70* Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92318754
71Shigellosis_Homo sapiens_hsa051310.91350306
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90959113
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.90326699
74Huntingtons disease_Homo sapiens_hsa050160.86929224
75Glycerolipid metabolism_Homo sapiens_hsa005610.86133959
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84128958
77Galactose metabolism_Homo sapiens_hsa000520.83994054
78Chemical carcinogenesis_Homo sapiens_hsa052040.82796526
79p53 signaling pathway_Homo sapiens_hsa041150.80782389
80DNA replication_Homo sapiens_hsa030300.80449775
81Legionellosis_Homo sapiens_hsa051340.80167035
82Tyrosine metabolism_Homo sapiens_hsa003500.79830432
83RNA degradation_Homo sapiens_hsa030180.77928233
84Insulin signaling pathway_Homo sapiens_hsa049100.74789744
85Glucagon signaling pathway_Homo sapiens_hsa049220.72973279
86N-Glycan biosynthesis_Homo sapiens_hsa005100.72321692
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.72280683
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72251666
89Antigen processing and presentation_Homo sapiens_hsa046120.71357557
90Epstein-Barr virus infection_Homo sapiens_hsa051690.70847961
91Pancreatic secretion_Homo sapiens_hsa049720.69638170
92Steroid biosynthesis_Homo sapiens_hsa001000.69477643
93Viral myocarditis_Homo sapiens_hsa054160.69289379
94Insulin secretion_Homo sapiens_hsa049110.68563243
95Protein export_Homo sapiens_hsa030600.67453432
96Fructose and mannose metabolism_Homo sapiens_hsa000510.66925643
97Lysosome_Homo sapiens_hsa041420.63202456
98Herpes simplex infection_Homo sapiens_hsa051680.63171494
99* Metabolic pathways_Homo sapiens_hsa011000.62885296
100Histidine metabolism_Homo sapiens_hsa003400.62698203
101Leishmaniasis_Homo sapiens_hsa051400.61046191
102Complement and coagulation cascades_Homo sapiens_hsa046100.59811492
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57309727
104Bladder cancer_Homo sapiens_hsa052190.56733352
105Arginine and proline metabolism_Homo sapiens_hsa003300.56379558
106Viral carcinogenesis_Homo sapiens_hsa052030.55930134
107Vitamin B6 metabolism_Homo sapiens_hsa007500.55322758
108Asthma_Homo sapiens_hsa053100.55102635
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54185544
110Insulin resistance_Homo sapiens_hsa049310.52624705
111Circadian entrainment_Homo sapiens_hsa047130.52432708
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50931629
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49233754
114Basal transcription factors_Homo sapiens_hsa030220.49122011
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48922635
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47603233
117Lysine degradation_Homo sapiens_hsa003100.46508006
118Salmonella infection_Homo sapiens_hsa051320.46231987
119Oocyte meiosis_Homo sapiens_hsa041140.45924560
120Other glycan degradation_Homo sapiens_hsa005110.45180217
121Apoptosis_Homo sapiens_hsa042100.44799356
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44017805
123HTLV-I infection_Homo sapiens_hsa051660.43503596
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42228691
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41838531
126Staphylococcus aureus infection_Homo sapiens_hsa051500.40796610
127Gastric acid secretion_Homo sapiens_hsa049710.39438978
128mRNA surveillance pathway_Homo sapiens_hsa030150.39135322
129Phagosome_Homo sapiens_hsa041450.39096566
130Fatty acid biosynthesis_Homo sapiens_hsa000610.37597162
131Tuberculosis_Homo sapiens_hsa051520.36894082
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36715133
133Glutathione metabolism_Homo sapiens_hsa004800.36310213
134Thyroid hormone synthesis_Homo sapiens_hsa049180.36269480
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.35932897
136Calcium signaling pathway_Homo sapiens_hsa040200.35446601
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33908898
138Retinol metabolism_Homo sapiens_hsa008300.33772315
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33682636
140Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32396636
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32345648
142Rheumatoid arthritis_Homo sapiens_hsa053230.32252533
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.30194263
144Long-term potentiation_Homo sapiens_hsa047200.29925497
145Vibrio cholerae infection_Homo sapiens_hsa051100.28792543
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28746277
147Thyroid cancer_Homo sapiens_hsa052160.28272343
148Salivary secretion_Homo sapiens_hsa049700.28243148
149Olfactory transduction_Homo sapiens_hsa047400.25848457
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24506188
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24009339
152Dilated cardiomyopathy_Homo sapiens_hsa054140.22515140
153Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21297050
154AMPK signaling pathway_Homo sapiens_hsa041520.20482962
155Renin secretion_Homo sapiens_hsa049240.20266769
156Oxytocin signaling pathway_Homo sapiens_hsa049210.18652491

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