COPS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.03011415
2ATP synthesis coupled proton transport (GO:0015986)5.59140081
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.59140081
4proteasome assembly (GO:0043248)5.22473353
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.92623405
6* cullin deneddylation (GO:0010388)4.77077973
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.70317017
8regulation of cellular amino acid metabolic process (GO:0006521)4.69229163
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.68533665
10chaperone-mediated protein transport (GO:0072321)4.57808578
11negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.55340153
12negative regulation of ligase activity (GO:0051352)4.55340153
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.53458691
14anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.47080865
15* protein deneddylation (GO:0000338)4.41198958
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.33322350
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.28884437
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.26295506
19intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.25615116
20signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.25615116
21protein neddylation (GO:0045116)4.24302364
22formation of translation preinitiation complex (GO:0001731)4.21817426
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.21030979
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.21030979
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.21030979
26signal transduction involved in DNA damage checkpoint (GO:0072422)4.11590145
27signal transduction involved in DNA integrity checkpoint (GO:0072401)4.11590145
28positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.08403983
29signal transduction involved in cell cycle checkpoint (GO:0072395)4.05523926
30respiratory electron transport chain (GO:0022904)4.01534767
31electron transport chain (GO:0022900)3.94156586
32termination of RNA polymerase III transcription (GO:0006386)3.94140518
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.94140518
34maturation of SSU-rRNA (GO:0030490)3.93515647
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91611597
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.91611597
37NADH dehydrogenase complex assembly (GO:0010257)3.91611597
38positive regulation of ligase activity (GO:0051351)3.91537540
39respiratory chain complex IV assembly (GO:0008535)3.91509898
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.84953055
41ribosomal small subunit biogenesis (GO:0042274)3.83417653
42regulation of mitochondrial translation (GO:0070129)3.82044036
437-methylguanosine mRNA capping (GO:0006370)3.79814943
44RNA capping (GO:0036260)3.76242417
457-methylguanosine RNA capping (GO:0009452)3.76242417
46protein complex biogenesis (GO:0070271)3.74410169
47establishment of integrated proviral latency (GO:0075713)3.72591281
48viral transcription (GO:0019083)3.68566524
49translational termination (GO:0006415)3.67686626
50amino acid salvage (GO:0043102)3.65882849
51L-methionine salvage (GO:0071267)3.65882849
52L-methionine biosynthetic process (GO:0071265)3.65882849
53mitochondrial respiratory chain complex assembly (GO:0033108)3.64684497
54establishment of protein localization to mitochondrion (GO:0072655)3.63660066
55ribosomal large subunit biogenesis (GO:0042273)3.63638563
56regulation of ubiquitin-protein transferase activity (GO:0051438)3.63551731
57protein targeting to mitochondrion (GO:0006626)3.59689766
58regulation of cellular amine metabolic process (GO:0033238)3.54985086
59spliceosomal snRNP assembly (GO:0000387)3.51853071
60regulation of ligase activity (GO:0051340)3.51346838
61* translation (GO:0006412)3.50661819
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.50175290
63cytochrome complex assembly (GO:0017004)3.48072039
64cotranslational protein targeting to membrane (GO:0006613)3.45052422
65GTP biosynthetic process (GO:0006183)3.42798228
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42152217
67protein localization to mitochondrion (GO:0070585)3.40526377
68* translational initiation (GO:0006413)3.40511224
69DNA strand elongation involved in DNA replication (GO:0006271)3.40177229
70protein targeting to ER (GO:0045047)3.37845763
71translational elongation (GO:0006414)3.34830674
72positive regulation of cell cycle arrest (GO:0071158)3.34260490
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32187767
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30979406
75protein localization to endoplasmic reticulum (GO:0070972)3.29360477
76branched-chain amino acid catabolic process (GO:0009083)3.29186626
77guanosine-containing compound biosynthetic process (GO:1901070)3.28757343
78purine nucleobase biosynthetic process (GO:0009113)3.28636473
79DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.27259774
80de novo protein folding (GO:0006458)3.27028263
81protein-cofactor linkage (GO:0018065)3.26343231
82DNA replication checkpoint (GO:0000076)3.24298977
83cellular component biogenesis (GO:0044085)3.23579707
84ribonucleoprotein complex biogenesis (GO:0022613)3.22881024
85peptidyl-histidine modification (GO:0018202)3.22496553
86nucleobase biosynthetic process (GO:0046112)3.20909826
87establishment of protein localization to endoplasmic reticulum (GO:0072599)3.20838221
88G1/S transition of mitotic cell cycle (GO:0000082)3.19242510
89cell cycle G1/S phase transition (GO:0044843)3.19242510
90DNA strand elongation (GO:0022616)3.19186759
91DNA double-strand break processing (GO:0000729)3.18609950
92de novo posttranslational protein folding (GO:0051084)3.18461620
93DNA replication initiation (GO:0006270)3.16862983
94CENP-A containing nucleosome assembly (GO:0034080)3.15668989
95DNA deamination (GO:0045006)3.15394407
96establishment of viral latency (GO:0019043)3.14652266
97cellular protein complex disassembly (GO:0043624)3.14008777
98ribosomal small subunit assembly (GO:0000028)3.13335182
99oxidative phosphorylation (GO:0006119)3.13313541
100rRNA modification (GO:0000154)3.12779702
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12418277
102tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12418277
103UTP biosynthetic process (GO:0006228)3.12064861
104spliceosomal complex assembly (GO:0000245)3.11683567
105chromatin remodeling at centromere (GO:0031055)3.11384407
106transcription elongation from RNA polymerase I promoter (GO:0006362)3.09690617
107deoxyribonucleotide biosynthetic process (GO:0009263)3.08325080
108ribosome assembly (GO:0042255)3.07010687
109water-soluble vitamin biosynthetic process (GO:0042364)3.06855970
110rRNA processing (GO:0006364)3.05645639
111transcription-coupled nucleotide-excision repair (GO:0006283)3.04715871
112deoxyribose phosphate biosynthetic process (GO:0046385)3.04512372
113inner mitochondrial membrane organization (GO:0007007)2.96620123
114ubiquinone biosynthetic process (GO:0006744)2.91302732
115maturation of 5.8S rRNA (GO:0000460)2.90967073
116pseudouridine synthesis (GO:0001522)2.88626255
117intracellular protein transmembrane import (GO:0044743)2.84474677
118purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83595786
119replication fork processing (GO:0031297)2.82203381
120ATP biosynthetic process (GO:0006754)2.81917614
121aerobic respiration (GO:0009060)2.81179694
122purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.80702573
123hydrogen ion transmembrane transport (GO:1902600)2.79617254
124pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76860695
125cellular respiration (GO:0045333)2.76128286
126regulation of mitotic spindle checkpoint (GO:1903504)2.75971014
127regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75971014
128ubiquinone metabolic process (GO:0006743)2.75397569
129tRNA processing (GO:0008033)2.74525670
130base-excision repair, AP site formation (GO:0006285)2.72595101
131tRNA metabolic process (GO:0006399)2.71635595
132preassembly of GPI anchor in ER membrane (GO:0016254)2.71379422
133rRNA methylation (GO:0031167)2.70151634
134organelle disassembly (GO:1903008)2.66259772
135DNA catabolic process, exonucleolytic (GO:0000738)2.62518655
136mitochondrial RNA metabolic process (GO:0000959)2.62508734
137IMP biosynthetic process (GO:0006188)2.61354763
138amino acid activation (GO:0043038)2.59972988
139tRNA aminoacylation (GO:0043039)2.59972988
140proton transport (GO:0015992)2.59536552
141cellular ketone body metabolic process (GO:0046950)2.58745874
142histone exchange (GO:0043486)2.58536934
143histone mRNA metabolic process (GO:0008334)2.57355289
144ribonucleoprotein complex disassembly (GO:0032988)2.57325419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.93664346
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.46743219
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.37326878
4E2F7_22180533_ChIP-Seq_HELA_Human4.33363851
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.07730386
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.02267543
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.75805513
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72915149
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.67619644
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.65214462
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28290943
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26590375
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.22759249
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19280066
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.17070757
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.03182650
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92186173
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89154881
19VDR_22108803_ChIP-Seq_LS180_Human2.79834688
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72395171
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65913462
22* VDR_23849224_ChIP-Seq_CD4+_Human2.50649918
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.49261217
24XRN2_22483619_ChIP-Seq_HELA_Human2.49160069
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45681476
26DCP1A_22483619_ChIP-Seq_HELA_Human2.43166413
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42695357
28ZNF274_21170338_ChIP-Seq_K562_Hela2.42255339
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.37805129
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35000403
31IGF1R_20145208_ChIP-Seq_DFB_Human2.33598432
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20091597
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.16539896
34ELK1_19687146_ChIP-ChIP_HELA_Human2.12223152
35GABP_19822575_ChIP-Seq_HepG2_Human2.11880632
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07900916
37* FOXP3_21729870_ChIP-Seq_TREG_Human2.07553165
38TTF2_22483619_ChIP-Seq_HELA_Human2.05747971
39* FLI1_27457419_Chip-Seq_LIVER_Mouse2.02457664
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.99611195
41* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99572570
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92788053
43EWS_26573619_Chip-Seq_HEK293_Human1.91808223
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83783754
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81270975
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79104891
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77014657
48AR_21909140_ChIP-Seq_LNCAP_Human1.75002549
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70915237
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70908507
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63325583
52* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61952722
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61821359
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55382657
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52497618
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51963481
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.50198660
58* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47681110
59* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45547695
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44617958
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42074172
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.40281314
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35320712
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.34747504
65TAF15_26573619_Chip-Seq_HEK293_Human1.30988396
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28080145
67MYC_18940864_ChIP-ChIP_HL60_Human1.27806631
68TP53_22573176_ChIP-Seq_HFKS_Human1.27217147
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27135594
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.26951596
71P300_19829295_ChIP-Seq_ESCs_Human1.24885320
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24022657
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21666026
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21521178
75* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19650834
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19107698
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17340392
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12876730
79* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12667335
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12025687
81* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10933197
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10072239
83KDM5A_27292631_Chip-Seq_BREAST_Human1.09296071
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08524236
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07105329
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06176512
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05641778
88GBX2_23144817_ChIP-Seq_PC3_Human1.03859799
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.03517035
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03021267
91HTT_18923047_ChIP-ChIP_STHdh_Human1.00639003
92IRF1_19129219_ChIP-ChIP_H3396_Human1.00611812
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99379130
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98800632
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98738525
96ER_23166858_ChIP-Seq_MCF-7_Human0.98144587
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97849888
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97028659
99SOX2_19829295_ChIP-Seq_ESCs_Human0.97000451
100NANOG_19829295_ChIP-Seq_ESCs_Human0.97000451
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96928425
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94110270
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.93885067
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.92792799
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91707151
106CBP_20019798_ChIP-Seq_JUKART_Human0.91707151
107* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91344678
108CIITA_25753668_ChIP-Seq_RAJI_Human0.90860320
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88874437
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87904735
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87495022
112* EZH2_27294783_Chip-Seq_NPCs_Mouse0.87371603
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87321488
114AR_20517297_ChIP-Seq_VCAP_Human0.87100940
115* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86941877
116* NFE2_27457419_Chip-Seq_LIVER_Mouse0.86416521
117FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86278697
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.86278697
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85168851
120FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84518567
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83773322
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83568176
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83321840
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82500064
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81864681
126TFEB_21752829_ChIP-Seq_HELA_Human0.80737550
127* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79059948
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78606572
129* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77377059
130* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76718297
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76575400
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75941266
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.75814888
134FUS_26573619_Chip-Seq_HEK293_Human0.73614272
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71671301
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70821004
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.69846457
138* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.69491333
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69489868
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69267806
141* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68688555
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68313240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.31704976
2MP0003806_abnormal_nucleotide_metabolis4.12795051
3MP0001529_abnormal_vocalization3.93463099
4* MP0004957_abnormal_blastocyst_morpholog3.58055617
5* MP0008932_abnormal_embryonic_tissue2.96256912
6* MP0010094_abnormal_chromosome_stability2.63804383
7MP0008057_abnormal_DNA_replication2.62409417
8* MP0003077_abnormal_cell_cycle2.54546155
9MP0001905_abnormal_dopamine_level2.51829850
10MP0003111_abnormal_nucleus_morphology2.46286508
11MP0009379_abnormal_foot_pigmentation2.40397083
12MP0006036_abnormal_mitochondrial_physio2.30800894
13MP0009697_abnormal_copulation2.18202289
14* MP0008058_abnormal_DNA_repair2.09858477
15MP0006276_abnormal_autonomic_nervous2.08621923
16MP0006035_abnormal_mitochondrial_morpho2.06903947
17MP0003123_paternal_imprinting2.04286587
18MP0003718_maternal_effect1.99994607
19MP0003186_abnormal_redox_activity1.98738297
20MP0006072_abnormal_retinal_apoptosis1.95079710
21MP0002837_dystrophic_cardiac_calcinosis1.93073961
22MP0005410_abnormal_fertilization1.91299666
23MP0003315_abnormal_perineum_morphology1.90992534
24MP0004215_abnormal_myocardial_fiber1.90602781
25MP0000372_irregular_coat_pigmentation1.77178073
26* MP0001730_embryonic_growth_arrest1.76208745
27MP0000537_abnormal_urethra_morphology1.76159374
28MP0003122_maternal_imprinting1.68561120
29MP0001984_abnormal_olfaction1.63020029
30MP0002751_abnormal_autonomic_nervous1.62584043
31MP0008877_abnormal_DNA_methylation1.61979677
32MP0005551_abnormal_eye_electrophysiolog1.59296141
33MP0005075_abnormal_melanosome_morpholog1.57553830
34MP0003880_abnormal_central_pattern1.56310295
35MP0002160_abnormal_reproductive_system1.52042860
36MP0004142_abnormal_muscle_tone1.51848936
37MP0002822_catalepsy1.49612159
38MP0004147_increased_porphyrin_level1.48141573
39MP0005084_abnormal_gallbladder_morpholo1.47358382
40MP0005253_abnormal_eye_physiology1.46524376
41MP0009046_muscle_twitch1.46056758
42MP0000358_abnormal_cell_content/1.45926075
43MP0002102_abnormal_ear_morphology1.43943896
44MP0002638_abnormal_pupillary_reflex1.42759655
45MP0002234_abnormal_pharynx_morphology1.40169150
46MP0010030_abnormal_orbit_morphology1.39932030
47MP0006292_abnormal_olfactory_placode1.37527267
48MP0003195_calcinosis1.30675344
49MP0003656_abnormal_erythrocyte_physiolo1.30523997
50MP0001727_abnormal_embryo_implantation1.29020574
51MP0008260_abnormal_autophagy1.27337328
52MP0008007_abnormal_cellular_replicative1.26894623
53MP0003787_abnormal_imprinting1.25365942
54MP0003786_premature_aging1.25110138
55MP0002210_abnormal_sex_determination1.24222895
56MP0001986_abnormal_taste_sensitivity1.21573575
57MP0005394_taste/olfaction_phenotype1.21105975
58MP0005499_abnormal_olfactory_system1.21105975
59MP0002938_white_spotting1.19507505
60MP0001929_abnormal_gametogenesis1.18365989
61MP0008875_abnormal_xenobiotic_pharmacok1.17473879
62MP0004145_abnormal_muscle_electrophysio1.17447137
63MP0002272_abnormal_nervous_system1.17196308
64MP0008775_abnormal_heart_ventricle1.16828720
65MP0002163_abnormal_gland_morphology1.16290456
66* MP0000350_abnormal_cell_proliferation1.15762953
67MP0008872_abnormal_physiological_respon1.15489774
68MP0003221_abnormal_cardiomyocyte_apopto1.15254757
69MP0008789_abnormal_olfactory_epithelium1.14488553
70MP0003136_yellow_coat_color1.14312128
71MP0000749_muscle_degeneration1.13159147
72MP0000747_muscle_weakness1.11677490
73MP0002095_abnormal_skin_pigmentation1.10016314
74* MP0001697_abnormal_embryo_size1.09625698
75MP0001145_abnormal_male_reproductive1.09312498
76MP0000427_abnormal_hair_cycle1.08544038
77MP0003567_abnormal_fetal_cardiomyocyte1.07051370
78MP0001188_hyperpigmentation1.05332015
79MP0008961_abnormal_basal_metabolism1.04699412
80MP0008995_early_reproductive_senescence1.04689637
81MP0001542_abnormal_bone_strength1.03950723
82MP0003698_abnormal_male_reproductive1.02470729
83* MP0002080_prenatal_lethality1.01598780
84MP0002282_abnormal_trachea_morphology1.00955885
85MP0009745_abnormal_behavioral_response1.00916867
86MP0003119_abnormal_digestive_system1.00763601
87MP0001485_abnormal_pinna_reflex0.99256398
88MP0003950_abnormal_plasma_membrane0.98855168
89MP0003937_abnormal_limbs/digits/tail_de0.98825447
90MP0003121_genomic_imprinting0.97937087
91MP0004133_heterotaxia0.96088519
92MP0000631_abnormal_neuroendocrine_gland0.95574606
93MP0002736_abnormal_nociception_after0.95401041
94MP0005174_abnormal_tail_pigmentation0.94430470
95MP0005266_abnormal_metabolism0.93265221
96MP0005332_abnormal_amino_acid0.92867428
97MP0002653_abnormal_ependyma_morphology0.92863580
98MP0002734_abnormal_mechanical_nocicepti0.91260805
99MP0005379_endocrine/exocrine_gland_phen0.89936008
100MP0003890_abnormal_embryonic-extraembry0.88271850
101MP0000653_abnormal_sex_gland0.87883894
102MP0005408_hypopigmentation0.87689360
103MP0005389_reproductive_system_phenotype0.87055667
104* MP0002085_abnormal_embryonic_tissue0.87041431
105MP0003137_abnormal_impulse_conducting0.86801296
106MP0000647_abnormal_sebaceous_gland0.83645156
107MP0001919_abnormal_reproductive_system0.82252149
108MP0000750_abnormal_muscle_regeneration0.81378185
109MP0002735_abnormal_chemical_nociception0.80978375
110MP0001968_abnormal_touch/_nociception0.80654219
111MP0004270_analgesia0.80612174
112MP0001764_abnormal_homeostasis0.80098345
113MP0001293_anophthalmia0.79854286
114* MP0000313_abnormal_cell_death0.78865203
115MP0005451_abnormal_body_composition0.78658986
116MP0002090_abnormal_vision0.77718584
117MP0000049_abnormal_middle_ear0.77679493
118MP0005187_abnormal_penis_morphology0.77522994
119MP0010386_abnormal_urinary_bladder0.77366186
120MP0004885_abnormal_endolymph0.75701881
121* MP0001672_abnormal_embryogenesis/_devel0.74763120
122* MP0005380_embryogenesis_phenotype0.74763120
123MP0003011_delayed_dark_adaptation0.74657663
124MP0009250_abnormal_appendicular_skeleto0.74652450
125MP0003942_abnormal_urinary_system0.74317549
126MP0003938_abnormal_ear_development0.72641331
127MP0002277_abnormal_respiratory_mucosa0.71905936
128MP0002269_muscular_atrophy0.71415431
129MP0002733_abnormal_thermal_nociception0.71216727
130MP0002876_abnormal_thyroid_physiology0.69507246
131MP0005646_abnormal_pituitary_gland0.68225876
132MP0002161_abnormal_fertility/fecundity0.68161844
133MP0005195_abnormal_posterior_eye0.67353359
134MP0000762_abnormal_tongue_morphology0.67130850
135MP0003252_abnormal_bile_duct0.66841774
136MP0001440_abnormal_grooming_behavior0.65781960
137* MP0002084_abnormal_developmental_patter0.65252837
138* MP0003984_embryonic_growth_retardation0.64630745
139MP0000751_myopathy0.63747404
140MP0005376_homeostasis/metabolism_phenot0.63564756
141MP0004134_abnormal_chest_morphology0.62842197
142MP0003646_muscle_fatigue0.62091056
143MP0005636_abnormal_mineral_homeostasis0.60165241
144* MP0002088_abnormal_embryonic_growth/wei0.60161393

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.92540296
2Abnormality of glycolysis (HP:0004366)5.38519619
3Increased serum pyruvate (HP:0003542)5.38519619
4Abnormal mitochondria in muscle tissue (HP:0008316)5.33413508
5Mitochondrial inheritance (HP:0001427)5.03726681
6Progressive macrocephaly (HP:0004481)4.77088184
7Acute encephalopathy (HP:0006846)4.70400687
8Increased CSF lactate (HP:0002490)4.56397464
9Hepatocellular necrosis (HP:0001404)4.43973539
10Cerebral hypomyelination (HP:0006808)4.37002078
11Increased hepatocellular lipid droplets (HP:0006565)3.95294220
12Hepatic necrosis (HP:0002605)3.89902199
13Lipid accumulation in hepatocytes (HP:0006561)3.63134240
14Birth length less than 3rd percentile (HP:0003561)3.48836431
15Cerebral edema (HP:0002181)3.48609907
16Increased serum lactate (HP:0002151)3.36266397
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35897088
18Abnormality of cells of the erythroid lineage (HP:0012130)3.34269747
19Leukodystrophy (HP:0002415)3.24699656
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23862260
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23862260
22Exercise intolerance (HP:0003546)3.22177916
23Respiratory failure (HP:0002878)3.10204985
24Lactic acidosis (HP:0003128)3.08251888
253-Methylglutaconic aciduria (HP:0003535)3.05134858
26Breast hypoplasia (HP:0003187)3.01956095
27Abnormal number of erythroid precursors (HP:0012131)3.00189489
28Renal Fanconi syndrome (HP:0001994)2.92314341
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88811615
30Optic disc pallor (HP:0000543)2.86027438
31Irregular epiphyses (HP:0010582)2.83058656
32Increased intramyocellular lipid droplets (HP:0012240)2.82037871
33Pancreatic cysts (HP:0001737)2.79265832
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.75527954
35CNS demyelination (HP:0007305)2.71752223
36Emotional lability (HP:0000712)2.69539820
37Exertional dyspnea (HP:0002875)2.67385469
38Macrocytic anemia (HP:0001972)2.62326607
39Abnormality of midbrain morphology (HP:0002418)2.57622336
40Molar tooth sign on MRI (HP:0002419)2.57622336
41Methylmalonic acidemia (HP:0002912)2.54259460
42Neuroendocrine neoplasm (HP:0100634)2.51444345
43Carpal bone hypoplasia (HP:0001498)2.51258652
44Oral leukoplakia (HP:0002745)2.50738629
45Reticulocytopenia (HP:0001896)2.50668213
46Pancreatic fibrosis (HP:0100732)2.45608130
47CNS hypomyelination (HP:0003429)2.44523725
48True hermaphroditism (HP:0010459)2.43716745
49Delusions (HP:0000746)2.43513108
50Microvesicular hepatic steatosis (HP:0001414)2.39373202
51Abnormality of the labia minora (HP:0012880)2.37900804
52Methylmalonic aciduria (HP:0012120)2.37647317
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35298614
54Abnormality of alanine metabolism (HP:0010916)2.35298614
55Hyperalaninemia (HP:0003348)2.35298614
56Abnormality of serum amino acid levels (HP:0003112)2.34816291
57Increased muscle lipid content (HP:0009058)2.32017566
58Colon cancer (HP:0003003)2.31872793
59Postnatal microcephaly (HP:0005484)2.29548232
60Rough bone trabeculation (HP:0100670)2.27911094
61Congenital primary aphakia (HP:0007707)2.26921687
62Gait imbalance (HP:0002141)2.25989841
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.21895797
64Pheochromocytoma (HP:0002666)2.21345069
65Autoamputation (HP:0001218)2.20761726
66Secondary amenorrhea (HP:0000869)2.19596325
67Degeneration of anterior horn cells (HP:0002398)2.18466128
68Abnormality of the anterior horn cell (HP:0006802)2.18466128
69Respiratory difficulties (HP:0002880)2.17400762
70Aplastic anemia (HP:0001915)2.16557510
71Hypothermia (HP:0002045)2.13699913
72Amniotic constriction ring (HP:0009775)2.13549232
73Abnormality of placental membranes (HP:0011409)2.13549232
74Abnormal glycosylation (HP:0012345)2.09944194
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09944194
76Abnormal protein N-linked glycosylation (HP:0012347)2.09944194
77Abnormal protein glycosylation (HP:0012346)2.09944194
78Nephronophthisis (HP:0000090)2.09129407
79Type I transferrin isoform profile (HP:0003642)2.08685669
80Hyperglycinuria (HP:0003108)2.08652209
81Renal cortical cysts (HP:0000803)2.07563425
82Hyperglycinemia (HP:0002154)2.06784196
83Unsteady gait (HP:0002317)2.06306912
84Nemaline bodies (HP:0003798)2.05680480
85Meckel diverticulum (HP:0002245)2.04772208
86Nephrogenic diabetes insipidus (HP:0009806)2.01920411
87Spastic paraparesis (HP:0002313)2.01111171
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00082022
89Congenital ichthyosiform erythroderma (HP:0007431)1.99615686
90Type 2 muscle fiber atrophy (HP:0003554)1.99010865
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96845381
92Abnormality of urine glucose concentration (HP:0011016)1.95959708
93Glycosuria (HP:0003076)1.95959708
94Premature ovarian failure (HP:0008209)1.95321030
95Lethargy (HP:0001254)1.95319151
96Stenosis of the external auditory canal (HP:0000402)1.95203715
97Abnormality of the renal cortex (HP:0011035)1.94655886
98Pallor (HP:0000980)1.94093629
99Abnormality of the ileum (HP:0001549)1.92893606
100Congenital, generalized hypertrichosis (HP:0004540)1.92180693
101Hypoplastic pelvis (HP:0008839)1.91764861
102Abnormality of glycine metabolism (HP:0010895)1.89600587
103Abnormality of serine family amino acid metabolism (HP:0010894)1.89600587
104Poor suck (HP:0002033)1.87765004
105Microretrognathia (HP:0000308)1.87181473
106Absent epiphyses (HP:0010577)1.86343923
107Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86343923
108Abnormal pupillary function (HP:0007686)1.84506705
109Medial flaring of the eyebrow (HP:0010747)1.84052187
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82969839
111Abnormality of methionine metabolism (HP:0010901)1.81087048
112Abnormality of renal resorption (HP:0011038)1.80722483
113Palpitations (HP:0001962)1.80628571
114Abnormality of the umbilical cord (HP:0010881)1.80490837
115Generalized aminoaciduria (HP:0002909)1.79659799
116Ketosis (HP:0001946)1.78081558
117Abnormality of chromosome stability (HP:0003220)1.77697953
118Glossoptosis (HP:0000162)1.76831629
119Parakeratosis (HP:0001036)1.76460195
120Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.76115720
121Large for gestational age (HP:0001520)1.75892794
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75693050
123Abnormality of the preputium (HP:0100587)1.75648387
124Abnormality of the renal collecting system (HP:0004742)1.75545375
125Abnormal umbilical cord blood vessels (HP:0011403)1.75312983
126Single umbilical artery (HP:0001195)1.75312983
127Abnormality of the fetal cardiovascular system (HP:0010948)1.75312983
128Multiple enchondromatosis (HP:0005701)1.74659873
129Muscle fiber inclusion bodies (HP:0100299)1.74546419
130Adrenal hypoplasia (HP:0000835)1.74132444
131Sclerocornea (HP:0000647)1.73871854
132Patellar aplasia (HP:0006443)1.73866839
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.73153341
134Abnormal autonomic nervous system physiology (HP:0012332)1.72499790
135Aplasia/hypoplasia of the uterus (HP:0008684)1.72307595
136Calcaneovalgus deformity (HP:0001848)1.72007034
137Neoplasm of the adrenal gland (HP:0100631)1.71233565
138Abolished electroretinogram (ERG) (HP:0000550)1.71088812
139X-linked dominant inheritance (HP:0001423)1.70614527
140Chromsome breakage (HP:0040012)1.70314512
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.70282819
142Ketoacidosis (HP:0001993)1.70158288
143Genital tract atresia (HP:0001827)1.69489588
144Abnormal respiratory motile cilium morphology (HP:0005938)1.69251341
145Abnormal respiratory epithelium morphology (HP:0012253)1.69251341
146Abnormality of the renal medulla (HP:0100957)1.68909080
147Abnormal lung lobation (HP:0002101)1.68251388
148Vaginal atresia (HP:0000148)1.66711667
149Aplasia/Hypoplasia of the patella (HP:0006498)1.66497713
150Oligodactyly (hands) (HP:0001180)1.66003372
151Blindness (HP:0000618)1.65461627
152Abnormalities of placenta or umbilical cord (HP:0001194)1.65362036
153Type II lissencephaly (HP:0007260)1.65297621
154Trismus (HP:0000211)1.64278720
155Abnormality of the pons (HP:0007361)1.64014741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.56607704
2EIF2AK13.75744771
3WEE13.60631162
4STK163.12008878
5LIMK12.60283492
6NME22.50179822
7TESK22.45588261
8PBK2.43902966
9FRK2.33885307
10NME12.28735624
11EIF2AK32.25348618
12TESK12.14112224
13VRK22.09616101
14CDC72.04644848
15MAP4K22.03958691
16PNCK2.03141720
17NUAK11.91908970
18BRSK21.90965754
19BCR1.89989832
20SRPK11.89415077
21CDK191.88753036
22VRK11.85946191
23TSSK61.82803270
24ACVR1B1.78633434
25PLK41.76789174
26TRIM281.72725617
27NEK11.71303928
28ARAF1.59678942
29MAP3K121.56917156
30TLK11.55047020
31STK391.46935186
32MAP3K41.43941074
33PLK31.42241310
34AURKA1.41955629
35BRSK11.38956512
36PDK41.37662618
37PDK31.37662618
38DYRK21.37492135
39CCNB11.36806582
40PLK11.29459255
41MKNK21.27991752
42PIM21.26425840
43OBSCN1.23686984
44ERBB31.23451254
45CSNK1G31.22432387
46MKNK11.21284354
47GRK11.19100619
48MST41.18480255
49MAP3K111.12760708
50TAF11.09285926
51TNIK1.00147613
52BRAF0.95510832
53CDK80.95292092
54DYRK30.94648764
55MUSK0.90143920
56PLK20.89145012
57PDK20.87828231
58TTK0.85153198
59PHKG10.84522849
60PHKG20.84522849
61BCKDK0.83418610
62CSNK1G10.80170013
63AURKB0.79900697
64PAK10.78615114
65OXSR10.76363751
66CDK140.75660199
67PINK10.75565355
68NEK20.71271067
69INSRR0.70866497
70ZAK0.70718326
71CSNK2A20.69775260
72CSNK2A10.69097559
73CHEK20.68146775
74BMPR1B0.68096947
75MYLK0.67975781
76CASK0.66804318
77ABL20.65553416
78MINK10.64022431
79PRKCG0.63697165
80CSNK1G20.63006140
81TXK0.62609591
82MAPKAPK50.62395296
83CDK70.62222398
84WNK30.62206571
85CDK180.61698110
86DAPK10.61167660
87WNK40.60856538
88CDK11A0.58105507
89PASK0.57513202
90STK38L0.57109066
91ILK0.57088060
92EPHA20.56697528
93TAOK30.56610838
94PRKCE0.56127570
95MAP2K70.53817960
96CDK150.53665743
97GRK70.53627042
98MARK10.53281731
99RPS6KB20.53108674
100CSNK1A1L0.51114860
101EIF2AK20.51001137
102ATM0.49785551
103ATR0.48988102
104UHMK10.48207429
105PAK30.46450900
106KDR0.45734476
107TIE10.44889798
108RPS6KA50.44536811
109CHEK10.43388147
110ADRBK10.41616580
111TGFBR10.41500706
112TEC0.40524184
113PRKCI0.39641821
114KSR10.39625491
115PAK40.38738188
116RPS6KA40.38392929
117SIK30.37957353
118LATS20.37779031
119CSNK1A10.37383981
120GRK50.37208988
121PIK3CG0.36860409
122CAMK2A0.36813855
123ADRBK20.35785308
124MAPK130.35220385
125DAPK20.34390731
126MAP2K60.31916741
127CSNK1E0.30836397
128MAP3K80.29710014
129YES10.29078307
130STK240.28961587
131PIK3CA0.27974358
132PRKACA0.27785425
133PRKACB0.27518018

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.58497682
2Oxidative phosphorylation_Homo sapiens_hsa001903.90550850
3Ribosome_Homo sapiens_hsa030103.86627234
4Parkinsons disease_Homo sapiens_hsa050123.53684655
5RNA polymerase_Homo sapiens_hsa030203.52522545
6DNA replication_Homo sapiens_hsa030302.97505828
7Huntingtons disease_Homo sapiens_hsa050162.70651738
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57226465
9Mismatch repair_Homo sapiens_hsa034302.44422782
10Protein export_Homo sapiens_hsa030602.40528647
11Spliceosome_Homo sapiens_hsa030402.40463927
12Pyrimidine metabolism_Homo sapiens_hsa002402.33892560
13Alzheimers disease_Homo sapiens_hsa050102.33770010
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21569851
15RNA transport_Homo sapiens_hsa030132.21020695
16Nucleotide excision repair_Homo sapiens_hsa034202.11364923
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95159168
18Basal transcription factors_Homo sapiens_hsa030221.91457104
19Base excision repair_Homo sapiens_hsa034101.75377862
20Homologous recombination_Homo sapiens_hsa034401.75303646
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70333936
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57842052
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48500926
24Cell cycle_Homo sapiens_hsa041101.48415459
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45780465
26Cardiac muscle contraction_Homo sapiens_hsa042601.35733398
27Purine metabolism_Homo sapiens_hsa002301.33941689
28Steroid biosynthesis_Homo sapiens_hsa001001.27220850
29Caffeine metabolism_Homo sapiens_hsa002321.22606164
30Fatty acid elongation_Homo sapiens_hsa000621.22143395
31Glutathione metabolism_Homo sapiens_hsa004801.21696342
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.17568695
33Pyruvate metabolism_Homo sapiens_hsa006201.17541164
34RNA degradation_Homo sapiens_hsa030181.13778798
35Non-homologous end-joining_Homo sapiens_hsa034501.13713570
36Folate biosynthesis_Homo sapiens_hsa007901.09449921
37One carbon pool by folate_Homo sapiens_hsa006701.08471866
38Vitamin B6 metabolism_Homo sapiens_hsa007501.05729047
39Fatty acid metabolism_Homo sapiens_hsa012121.00294075
40Sulfur relay system_Homo sapiens_hsa041221.00073029
41Phototransduction_Homo sapiens_hsa047440.96889536
42Carbon metabolism_Homo sapiens_hsa012000.94852335
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91763384
44Nitrogen metabolism_Homo sapiens_hsa009100.91077854
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89984200
46Pentose phosphate pathway_Homo sapiens_hsa000300.88863398
47Tryptophan metabolism_Homo sapiens_hsa003800.88798176
48Fanconi anemia pathway_Homo sapiens_hsa034600.88296670
49Epstein-Barr virus infection_Homo sapiens_hsa051690.88247552
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84790932
51Fatty acid degradation_Homo sapiens_hsa000710.84410689
52Metabolic pathways_Homo sapiens_hsa011000.82206734
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81877111
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81757358
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80293906
56Collecting duct acid secretion_Homo sapiens_hsa049660.79781820
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78944296
58Biosynthesis of amino acids_Homo sapiens_hsa012300.78401922
59mRNA surveillance pathway_Homo sapiens_hsa030150.77012037
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.76723730
61Oocyte meiosis_Homo sapiens_hsa041140.74949930
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73450878
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72561932
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72333094
65Tyrosine metabolism_Homo sapiens_hsa003500.71714307
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68692308
67Arginine and proline metabolism_Homo sapiens_hsa003300.68332612
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.68019199
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66201416
70Retinol metabolism_Homo sapiens_hsa008300.65096560
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63107710
72Nicotine addiction_Homo sapiens_hsa050330.62434084
73Phenylalanine metabolism_Homo sapiens_hsa003600.61637322
74Vibrio cholerae infection_Homo sapiens_hsa051100.61261837
75Sulfur metabolism_Homo sapiens_hsa009200.59773750
76Regulation of autophagy_Homo sapiens_hsa041400.59660202
77Propanoate metabolism_Homo sapiens_hsa006400.58555087
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58013720
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.53693091
80Arachidonic acid metabolism_Homo sapiens_hsa005900.53512919
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52724060
82Olfactory transduction_Homo sapiens_hsa047400.49647389
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48511174
84p53 signaling pathway_Homo sapiens_hsa041150.48331838
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48223039
86Linoleic acid metabolism_Homo sapiens_hsa005910.44941450
87Ether lipid metabolism_Homo sapiens_hsa005650.43199337
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42562232
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42414350
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42314540
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40854794
92Systemic lupus erythematosus_Homo sapiens_hsa053220.40263409
93Butanoate metabolism_Homo sapiens_hsa006500.39781334
94Histidine metabolism_Homo sapiens_hsa003400.36881336
95Fatty acid biosynthesis_Homo sapiens_hsa000610.34058077
96Fructose and mannose metabolism_Homo sapiens_hsa000510.33501701
97Selenocompound metabolism_Homo sapiens_hsa004500.32596635
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31794301
99Peroxisome_Homo sapiens_hsa041460.31026021
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30513622
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30379239
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28864249
103Chemical carcinogenesis_Homo sapiens_hsa052040.28389289
104Taste transduction_Homo sapiens_hsa047420.27849299
105Starch and sucrose metabolism_Homo sapiens_hsa005000.27711535
106Fat digestion and absorption_Homo sapiens_hsa049750.26646739
107GABAergic synapse_Homo sapiens_hsa047270.26534548
108Alcoholism_Homo sapiens_hsa050340.26304360
109Phagosome_Homo sapiens_hsa041450.25326993
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22167471
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20894985
112beta-Alanine metabolism_Homo sapiens_hsa004100.17536225
113N-Glycan biosynthesis_Homo sapiens_hsa005100.17391576
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15807887
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12879058
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.11202844
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.09619090
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08891422
119Legionellosis_Homo sapiens_hsa051340.07402908
120Hedgehog signaling pathway_Homo sapiens_hsa043400.07253927
121Viral carcinogenesis_Homo sapiens_hsa052030.07222340
122Synaptic vesicle cycle_Homo sapiens_hsa047210.07097093
123Galactose metabolism_Homo sapiens_hsa000520.06743067
124Renin-angiotensin system_Homo sapiens_hsa046140.05687973

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