COPG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* COPI coating of Golgi vesicle (GO:0048205)6.24420627
2* Golgi transport vesicle coating (GO:0048200)6.24420627
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19369218
4synaptic vesicle maturation (GO:0016188)5.17029538
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04621905
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.96344303
7regulation of synaptic vesicle exocytosis (GO:2000300)4.47752686
8synaptic vesicle exocytosis (GO:0016079)4.46545933
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.44894640
10locomotory exploration behavior (GO:0035641)4.36748731
11protein localization to endosome (GO:0036010)4.34145491
12glutamate secretion (GO:0014047)4.27659044
13protein retention in ER lumen (GO:0006621)4.17533162
14activation of protein kinase A activity (GO:0034199)4.16029971
15cerebellar Purkinje cell layer development (GO:0021680)4.10912604
16* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.06555479
17skin morphogenesis (GO:0043589)4.04095824
18neurotransmitter secretion (GO:0007269)4.02688643
19cell adhesion mediated by integrin (GO:0033627)3.99545647
20basement membrane organization (GO:0071711)3.92547610
21proline transport (GO:0015824)3.88440908
22regulation of synaptic vesicle transport (GO:1902803)3.84065744
23vocalization behavior (GO:0071625)3.79860107
24proline biosynthetic process (GO:0006561)3.66759984
25barbed-end actin filament capping (GO:0051016)3.62536914
26activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.60378178
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.56927798
28* vesicle coating (GO:0006901)3.53237821
29desmosome organization (GO:0002934)3.43416489
30protein maturation by protein folding (GO:0022417)3.39093195
31positive regulation of nuclease activity (GO:0032075)3.38998039
32regulation of synapse structural plasticity (GO:0051823)3.37828522
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37683524
34layer formation in cerebral cortex (GO:0021819)3.36857648
35regulation of neuronal synaptic plasticity (GO:0048168)3.35637872
36regulation of glutamate receptor signaling pathway (GO:1900449)3.33810696
37peptidyl-proline hydroxylation (GO:0019511)3.33470339
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28179431
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26730106
40hemidesmosome assembly (GO:0031581)3.25685211
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.25025360
42exploration behavior (GO:0035640)3.24344188
43cell-substrate junction assembly (GO:0007044)3.23452699
44positive regulation of vesicle fusion (GO:0031340)3.23445545
45vesicle transport along microtubule (GO:0047496)3.22623885
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.22043505
47cell communication by electrical coupling (GO:0010644)3.18814534
48epithelial cell-cell adhesion (GO:0090136)3.18543018
49insulin secretion (GO:0030073)3.17561417
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14436170
51protein hydroxylation (GO:0018126)3.10573565
52glucose 6-phosphate metabolic process (GO:0051156)3.08875230
53negative regulation of cell size (GO:0045792)3.07468021
54pentose-phosphate shunt (GO:0006098)3.05365305
55adherens junction assembly (GO:0034333)3.04371133
56sodium ion export (GO:0071436)3.03112922
57COPII vesicle coating (GO:0048208)3.01769036
58neuronal action potential propagation (GO:0019227)2.99567867
59apoptotic cell clearance (GO:0043277)2.98480225
60regulation of nuclease activity (GO:0032069)2.97635475
61neurotransmitter transport (GO:0006836)2.97378957
62glycine transport (GO:0015816)2.96456043
63membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95073399
64membrane protein ectodomain proteolysis (GO:0006509)2.94603653
65cell-substrate adherens junction assembly (GO:0007045)2.94576924
66focal adhesion assembly (GO:0048041)2.94576924
67regulation of extracellular matrix disassembly (GO:0010715)2.94538888
68neuromuscular process controlling posture (GO:0050884)2.93170740
69regulation of cholesterol homeostasis (GO:2000188)2.93113175
70innervation (GO:0060384)2.92688367
71detection of calcium ion (GO:0005513)2.90918281
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90402911
73stress fiber assembly (GO:0043149)2.89395839
74negative regulation of fatty acid transport (GO:2000192)2.89194739
75endodermal cell differentiation (GO:0035987)2.88240266
76regulation of glucose import in response to insulin stimulus (GO:2001273)2.87715996
77regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87690478
78regulation of early endosome to late endosome transport (GO:2000641)2.87484936
79positive regulation of synapse maturation (GO:0090129)2.86913704
80cellular potassium ion homeostasis (GO:0030007)2.85741468
81cytoskeletal anchoring at plasma membrane (GO:0007016)2.85506056
82endoplasmic reticulum unfolded protein response (GO:0030968)2.84226126
83collagen fibril organization (GO:0030199)2.80775977
84positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.80633163
85regulation of vesicle fusion (GO:0031338)2.80308715
86neuromuscular process controlling balance (GO:0050885)2.80065859
87semaphorin-plexin signaling pathway (GO:0071526)2.78790559
88positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77790961
89signal release (GO:0023061)2.77469789
90maternal placenta development (GO:0001893)2.74856285
91protein localization to synapse (GO:0035418)2.74698783
92NADPH regeneration (GO:0006740)2.74238843
93cellular response to unfolded protein (GO:0034620)2.73991457
94glucose catabolic process (GO:0006007)2.73843970
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73829452
96regulation of neurotransmitter levels (GO:0001505)2.73496216
97cellular response to glucagon stimulus (GO:0071377)2.73459132
98response to endoplasmic reticulum stress (GO:0034976)2.73196087
99regulation of cholesterol biosynthetic process (GO:0045540)2.72904106
100vascular endothelial growth factor signaling pathway (GO:0038084)2.70795774
101activation of Rac GTPase activity (GO:0032863)2.69746116
102synaptic transmission, glutamatergic (GO:0035249)2.69089157
103regulation of synaptic plasticity (GO:0048167)2.68540833
104regulation of ARF protein signal transduction (GO:0032012)2.68271464
105alpha-linolenic acid metabolic process (GO:0036109)2.67657042
106ER-nucleus signaling pathway (GO:0006984)2.67307487
107membrane repolarization during action potential (GO:0086011)2.66710432
108chemosensory behavior (GO:0007635)2.66403293
109alanine transport (GO:0032328)2.66011072
110dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65721616
111establishment of nucleus localization (GO:0040023)2.65672480
112regulation of calcium ion-dependent exocytosis (GO:0017158)2.65608266
113gamma-aminobutyric acid transport (GO:0015812)2.65346096
114regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.65314030
115negative regulation of protein localization to plasma membrane (GO:1903077)2.65238825
116negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64741287
117peptide hormone processing (GO:0016486)2.64272361
1184-hydroxyproline metabolic process (GO:0019471)2.63810493
119endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.63643516
120neuron-neuron synaptic transmission (GO:0007270)2.63623627
121inner ear receptor cell development (GO:0060119)2.63549558
122cellular copper ion homeostasis (GO:0006878)2.63357950
123pinocytosis (GO:0006907)2.63141532
124protein N-linked glycosylation via asparagine (GO:0018279)2.62612934
125synaptic vesicle endocytosis (GO:0048488)2.61789484
126cellular response to topologically incorrect protein (GO:0035967)2.61552784
127branching involved in mammary gland duct morphogenesis (GO:0060444)2.60873486
128peptidyl-asparagine modification (GO:0018196)2.60666319
129cerebellar Purkinje cell differentiation (GO:0021702)2.60408932
130long-term synaptic potentiation (GO:0060291)2.60178853
131NADH metabolic process (GO:0006734)2.59077756
132regulation of type B pancreatic cell apoptotic process (GO:2000674)2.58000208
133intra-Golgi vesicle-mediated transport (GO:0006891)2.57895986
134positive regulation of membrane potential (GO:0045838)2.57444069
135ionotropic glutamate receptor signaling pathway (GO:0035235)2.56930484
136regulation of neurotransmitter secretion (GO:0046928)2.56929185
137dendritic spine morphogenesis (GO:0060997)2.55939045
138response to unfolded protein (GO:0006986)2.55276001
139hyaluronan catabolic process (GO:0030214)2.54711210
140response to laminar fluid shear stress (GO:0034616)2.52739876
141striatum development (GO:0021756)2.52470687
142protein heterotrimerization (GO:0070208)2.52448665
143amyloid precursor protein catabolic process (GO:0042987)2.51994952
144actin filament depolymerization (GO:0030042)2.51534787
145long-term memory (GO:0007616)2.49906325
146protein N-linked glycosylation (GO:0006487)2.49264093
147negative regulation of microtubule polymerization (GO:0031115)2.48923464
148extracellular matrix disassembly (GO:0022617)2.47256758
149embryo implantation (GO:0007566)2.47229689
150tricarboxylic acid metabolic process (GO:0072350)2.47209804
151membrane repolarization (GO:0086009)2.46848745
152planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46351863
153positive regulation of exocytosis (GO:0045921)2.46337730
154regulation of insulin secretion (GO:0050796)2.45893611
155proline metabolic process (GO:0006560)2.45511532
156vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.45184558
157glutamine family amino acid biosynthetic process (GO:0009084)2.45121937
158G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.44805422
159regulation of neurotransmitter transport (GO:0051588)2.43594017
160nucleotide-sugar biosynthetic process (GO:0009226)2.43366998
161L-serine transport (GO:0015825)2.43253552
162iron ion import (GO:0097286)2.43031642
163peptide hormone secretion (GO:0030072)2.42500007
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.41671341
165positive regulation of neurotransmitter transport (GO:0051590)2.41168228
166positive regulation of endothelial cell apoptotic process (GO:2000353)2.40209733
167dendritic spine organization (GO:0097061)2.40006064
168adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.39822251
169collagen metabolic process (GO:0032963)2.39664748
170regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.39519816
171response to topologically incorrect protein (GO:0035966)2.38924163
172regulation of excitatory postsynaptic membrane potential (GO:0060079)2.38417102
173regulation of exocytosis (GO:0017157)2.38168498
174suckling behavior (GO:0001967)2.37256354
175epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35730131
176embryonic process involved in female pregnancy (GO:0060136)2.34865507
177membrane raft organization (GO:0031579)2.34376217
178protein targeting to plasma membrane (GO:0072661)2.34128264
179positive regulation of extracellular matrix organization (GO:1903055)2.33870964
180multicellular organismal macromolecule metabolic process (GO:0044259)2.33290671
181positive regulation of receptor recycling (GO:0001921)2.32873058
182negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31685643
183positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.31432169
184GDP-mannose metabolic process (GO:0019673)2.31336482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.64222412
2EZH2_22144423_ChIP-Seq_EOC_Human4.31969223
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.90731311
4ZNF263_19887448_ChIP-Seq_K562_Human2.78274111
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72152720
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62285069
7DROSHA_22980978_ChIP-Seq_HELA_Human2.59909048
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58931684
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57349386
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55549389
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.42938158
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.42161764
13REST_21632747_ChIP-Seq_MESCs_Mouse2.40696873
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.35383339
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34809115
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34809115
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33333097
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31232685
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.29989953
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28317761
21GBX2_23144817_ChIP-Seq_PC3_Human2.26597126
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25307537
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25222338
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22267402
25RACK7_27058665_Chip-Seq_MCF-7_Human2.21790731
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16923127
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15471009
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13294529
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13116605
30JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12271024
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10212895
32ZFP281_18757296_ChIP-ChIP_E14_Mouse2.06148198
33HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05861614
34IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03363447
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.01061659
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00763763
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98718106
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96580194
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92465132
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92278446
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90193129
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88613336
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.84912558
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84441714
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.84392006
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.83436792
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.74479998
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74158279
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.73652511
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73581879
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73480521
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.72514476
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.71647105
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.70265791
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69941895
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69937075
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68650674
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.67380014
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65479740
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65036372
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62411498
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61706213
63KDM2B_26808549_Chip-Seq_K562_Human1.59193781
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57028568
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56350830
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55627512
67ATF3_27146783_Chip-Seq_COLON_Human1.55186302
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53423865
69ZNF274_21170338_ChIP-Seq_K562_Hela1.52741477
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49476910
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47971470
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47606038
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47388169
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43745782
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41370153
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39168685
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39168685
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38484927
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.38287446
80AR_19668381_ChIP-Seq_PC3_Human1.37608542
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36915180
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36614945
83MYC_22102868_ChIP-Seq_BL_Human1.35948594
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35882144
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35517537
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.34747711
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34476888
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34153753
89TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.33941726
90TP53_22127205_ChIP-Seq_IMR90_Human1.33203086
91SMAD4_21799915_ChIP-Seq_A2780_Human1.32656891
92VDR_21846776_ChIP-Seq_THP-1_Human1.32438519
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31049037
94TCF7_22412390_ChIP-Seq_EML_Mouse1.30280089
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28314826
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25429126
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24861884
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24834825
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23420032
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23244929
101CLOCK_20551151_ChIP-Seq_293T_Human1.23201461
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.22631484
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22117135
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21478777
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21462730
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20227447
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19420192
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18812000
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18390480
110AR_21909140_ChIP-Seq_LNCAP_Human1.18389774
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16873130
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15450249
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.14346008
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.14346008
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.13839150
116TET1_21490601_ChIP-Seq_MESCs_Mouse1.13280989
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13126097
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13027946
119SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12800598
120AR_21572438_ChIP-Seq_LNCaP_Human1.12570221
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11785380
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11158144
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10126401
124KDM2B_26808549_Chip-Seq_DND41_Human1.09401858
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.08222322
126TET1_21451524_ChIP-Seq_MESCs_Mouse1.08073794
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.07881973
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07193839
129LXR_22292898_ChIP-Seq_THP-1_Human1.06797230
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05860469
131STAT3_23295773_ChIP-Seq_U87_Human1.05360789
132CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05078269
133TFEB_21752829_ChIP-Seq_HELA_Human1.04301253
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03987119
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03686529
136ESR1_20079471_ChIP-ChIP_T-47D_Human1.03020220
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01889145
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01841120
139SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00513814
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98816595
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98697866
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96390321
143CREB1_26743006_Chip-Seq_LNCaP_Human0.95667696
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95480641
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.95244408
146SOX2_20726797_ChIP-Seq_SW620_Human0.95241450
147WT1_19549856_ChIP-ChIP_CCG9911_Human0.94766207
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94484908
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.94307080
150SMC4_20622854_ChIP-Seq_HELA_Human0.94199494
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94026106
152GATA6_25053715_ChIP-Seq_YYC3_Human0.94022037
153KLF4_19829295_ChIP-Seq_ESCs_Human0.93803799
154NCOR1_26117541_ChIP-Seq_K562_Human0.92732946
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92472269
156RING1B_27294783_Chip-Seq_NPCs_Mouse0.92130030
157CHD1_26751641_Chip-Seq_LNCaP_Human0.91911904
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91365176
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89489525
160PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89114385
161EGR1_19374776_ChIP-ChIP_THP-1_Human0.87869980
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87452964
163P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87080470
164RXR_22108803_ChIP-Seq_LS180_Human0.86029453
165CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85874615
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84749944
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.84591296
168SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84263383
169OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84212012
170AR_25329375_ChIP-Seq_VCAP_Human0.83813604
171CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83459739
172TP53_23651856_ChIP-Seq_MEFs_Mouse0.83228851
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83041885
174ISL1_27105846_Chip-Seq_CPCs_Mouse0.82860934
175ESR2_21235772_ChIP-Seq_MCF-7_Human0.80980452
176STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80961420
177TCF4_23295773_ChIP-Seq_U87_Human0.80827690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.88283167
2MP0009780_abnormal_chondrocyte_physiolo3.81693953
3MP0000013_abnormal_adipose_tissue3.54325871
4MP0003283_abnormal_digestive_organ3.44408005
5MP0002909_abnormal_adrenal_gland3.32290731
6MP0003566_abnormal_cell_adhesion3.26618714
7MP0005257_abnormal_intraocular_pressure3.06335408
8MP0003635_abnormal_synaptic_transmissio3.06162277
9MP0003122_maternal_imprinting2.96687112
10MP0005058_abnormal_lysosome_morphology2.71606716
11MP0004270_analgesia2.71229417
12MP0005451_abnormal_body_composition2.58991622
13MP0002877_abnormal_melanocyte_morpholog2.55957870
14MP0009840_abnormal_foam_cell2.44470718
15MP0002063_abnormal_learning/memory/cond2.35364508
16MP0009745_abnormal_behavioral_response2.27016999
17MP0003191_abnormal_cellular_cholesterol2.26992350
18MP0003880_abnormal_central_pattern2.14935241
19MP0002064_seizures2.12477245
20MP0003091_abnormal_cell_migration2.09813331
21MP0010352_gastrointestinal_tract_polyps2.07861821
22MP0001958_emphysema2.07624364
23MP0002822_catalepsy2.02678302
24MP0009046_muscle_twitch1.95540850
25MP0003123_paternal_imprinting1.91823125
26MP0003183_abnormal_peptide_metabolism1.89735231
27MP0001968_abnormal_touch/_nociception1.89355805
28MP0002060_abnormal_skin_morphology1.88813102
29MP0001849_ear_inflammation1.86527576
30MP0002572_abnormal_emotion/affect_behav1.86230941
31MP0008260_abnormal_autophagy1.85137489
32MP0005023_abnormal_wound_healing1.78265011
33MP0004858_abnormal_nervous_system1.76934638
34MP0002734_abnormal_mechanical_nocicepti1.76733646
35MP0008438_abnormal_cutaneous_collagen1.75182591
36MP0000003_abnormal_adipose_tissue1.74185378
37MP0003705_abnormal_hypodermis_morpholog1.69166605
38MP0003787_abnormal_imprinting1.68675146
39MP0002837_dystrophic_cardiac_calcinosis1.68040195
40MP0010386_abnormal_urinary_bladder1.64999469
41MP0008961_abnormal_basal_metabolism1.62225518
42MP0002272_abnormal_nervous_system1.58456378
43MP0002733_abnormal_thermal_nociception1.58401027
44MP0001501_abnormal_sleep_pattern1.58064439
45MP0005623_abnormal_meninges_morphology1.57481496
46MP0001944_abnormal_pancreas_morphology1.56794006
47MP0003941_abnormal_skin_development1.56165421
48MP0003300_gastrointestinal_ulcer1.54491829
49MP0003329_amyloid_beta_deposits1.51740655
50MP0010234_abnormal_vibrissa_follicle1.51300369
51MP0004811_abnormal_neuron_physiology1.50228955
52MP0005646_abnormal_pituitary_gland1.48990112
53MP0003453_abnormal_keratinocyte_physiol1.46283835
54MP0005645_abnormal_hypothalamus_physiol1.45740033
55MP0002736_abnormal_nociception_after1.44664005
56MP0009384_cardiac_valve_regurgitation1.41469645
57MP0004043_abnormal_pH_regulation1.38720726
58MP0004233_abnormal_muscle_weight1.38222782
59MP0001299_abnormal_eye_distance/1.33386606
60MP0005409_darkened_coat_color1.33048606
61MP0002896_abnormal_bone_mineralization1.32576578
62MP0001970_abnormal_pain_threshold1.31992869
63MP0008569_lethality_at_weaning1.31601754
64MP0002693_abnormal_pancreas_physiology1.30867849
65MP0002796_impaired_skin_barrier1.29253584
66MP0005503_abnormal_tendon_morphology1.27368446
67MP0000955_abnormal_spinal_cord1.26995001
68MP0000858_altered_metastatic_potential1.26027793
69MP0000767_abnormal_smooth_muscle1.25581961
70MP0002184_abnormal_innervation1.24750449
71MP0003172_abnormal_lysosome_physiology1.20298569
72MP0000678_abnormal_parathyroid_gland1.20005562
73MP0000537_abnormal_urethra_morphology1.19395574
74MP0002557_abnormal_social/conspecific_i1.19379431
75MP0000733_abnormal_muscle_development1.18543500
76MP0001348_abnormal_lacrimal_gland1.18221222
77MP0005501_abnormal_skin_physiology1.15957488
78MP0001243_abnormal_dermal_layer1.13716373
79MP0003121_genomic_imprinting1.12592281
80MP0006054_spinal_hemorrhage1.12533956
81MP0003879_abnormal_hair_cell1.12272017
82MP0002067_abnormal_sensory_capabilities1.12081103
83MP0003950_abnormal_plasma_membrane1.10851215
84MP0004782_abnormal_surfactant_physiolog1.10685894
85MP0010368_abnormal_lymphatic_system1.09877039
86MP0001486_abnormal_startle_reflex1.09826397
87MP0001440_abnormal_grooming_behavior1.08054958
88MP0001915_intracranial_hemorrhage1.07872927
89MP0002735_abnormal_chemical_nociception1.07666080
90MP0001542_abnormal_bone_strength1.07155784
91MP0002234_abnormal_pharynx_morphology1.05961526
92MP0004924_abnormal_behavior1.05528004
93MP0005386_behavior/neurological_phenoty1.05528004
94MP0005423_abnormal_somatic_nervous1.02124883
95MP0000751_myopathy0.98951746
96MP0002078_abnormal_glucose_homeostasis0.98884004
97MP0005165_increased_susceptibility_to0.98590839
98MP0000604_amyloidosis0.98315027
99MP0005621_abnormal_cell_physiology0.98168463
100MP0005408_hypopigmentation0.97652089
101MP0005508_abnormal_skeleton_morphology0.97401139
102MP0003045_fibrosis0.96575804
103MP0002066_abnormal_motor_capabilities/c0.95942124
104MP0006276_abnormal_autonomic_nervous0.94938155
105MP0000534_abnormal_ureter_morphology0.94127602
106MP0004947_skin_inflammation0.92892313
107MP0005275_abnormal_skin_tensile0.92886465
108MP0001216_abnormal_epidermal_layer0.92538036
109MP0004264_abnormal_extraembryonic_tissu0.88035562
110MP0004272_abnormal_basement_membrane0.87566252
111MP0002882_abnormal_neuron_morphology0.86800431
112MP0000467_abnormal_esophagus_morphology0.86738222
113MP0003633_abnormal_nervous_system0.86369476
114MP0004185_abnormal_adipocyte_glucose0.86245174
115MP0005375_adipose_tissue_phenotype0.84849720
116MP0000747_muscle_weakness0.83954680
117MP0001177_atelectasis0.83757975
118MP0002069_abnormal_eating/drinking_beha0.83600041
119MP0005187_abnormal_penis_morphology0.82373112
120MP0003279_aneurysm0.81879926
121MP0005171_absent_coat_pigmentation0.81547552
122MP0000569_abnormal_digit_pigmentation0.79598942
123MP0001661_extended_life_span0.78684237
124MP0003942_abnormal_urinary_system0.78053910
125MP0002089_abnormal_postnatal_growth/wei0.77749265
126MP0000759_abnormal_skeletal_muscle0.77691168
127MP0002295_abnormal_pulmonary_circulatio0.76888117
128MP0005220_abnormal_exocrine_pancreas0.76793954
129MP0003959_abnormal_lean_body0.76253372
130MP0003448_altered_tumor_morphology0.76099043
131MP0001984_abnormal_olfaction0.75637466
132MP0001270_distended_abdomen0.75260952
133MP0005164_abnormal_response_to0.75226804
134MP0003385_abnormal_body_wall0.75175735
135MP0000462_abnormal_digestive_system0.75025406
136MP0001881_abnormal_mammary_gland0.74922522
137MP0003075_altered_response_to0.74105429
138MP0005197_abnormal_uvea_morphology0.73050067
139MP0000627_abnormal_mammary_gland0.72583348
140MP0002098_abnormal_vibrissa_morphology0.72403586
141MP0004085_abnormal_heartbeat0.72295880
142MP0005535_abnormal_body_temperature0.71789244
143MP0003119_abnormal_digestive_system0.71548735
144MP0002152_abnormal_brain_morphology0.71507485
145MP0003868_abnormal_feces_composition0.71439586
146MP0001502_abnormal_circadian_rhythm0.70712507
147MP0003953_abnormal_hormone_level0.70582893
148MP0004885_abnormal_endolymph0.70334849
149MP0003634_abnormal_glial_cell0.69684911
150MP0005360_urolithiasis0.69610766
151MP0010030_abnormal_orbit_morphology0.69141057
152MP0002998_abnormal_bone_remodeling0.68876590
153MP0003795_abnormal_bone_structure0.68293630
154MP0005379_endocrine/exocrine_gland_phen0.68248879
155MP0000631_abnormal_neuroendocrine_gland0.68110915
156MP0010771_integument_phenotype0.68047135
157MP0005076_abnormal_cell_differentiation0.67282283
158MP0000377_abnormal_hair_follicle0.67064329
159MP0005384_cellular_phenotype0.66826781
160MP0001765_abnormal_ion_homeostasis0.66379359
161MP0000750_abnormal_muscle_regeneration0.65443831
162MP0001730_embryonic_growth_arrest0.65361581
163MP0002653_abnormal_ependyma_morphology0.65324243
164MP0001664_abnormal_digestion0.65001283
165MP0001614_abnormal_blood_vessel0.64990033
166MP0002086_abnormal_extraembryonic_tissu0.64394431
167MP0000762_abnormal_tongue_morphology0.64346606
168MP0003631_nervous_system_phenotype0.64182430
169MP0002269_muscular_atrophy0.63921109
170MP0002108_abnormal_muscle_morphology0.63528598
171MP0009931_abnormal_skin_appearance0.62872122
172MP0002139_abnormal_hepatobiliary_system0.61683676
173MP0005390_skeleton_phenotype0.59274336
174MP0002166_altered_tumor_susceptibility0.58152866

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.41116184
2Visual hallucinations (HP:0002367)3.84397794
3Focal motor seizures (HP:0011153)3.72363142
4Vertebral compression fractures (HP:0002953)3.67120887
5Myokymia (HP:0002411)3.42895935
6Atonic seizures (HP:0010819)3.34072266
7Focal seizures (HP:0007359)3.23916978
8Protrusio acetabuli (HP:0003179)3.20376469
9Aortic dissection (HP:0002647)3.20077635
10Vascular tortuosity (HP:0004948)3.05535879
11Arterial tortuosity (HP:0005116)3.05151268
12Atrophic scars (HP:0001075)2.98491670
13Resting tremor (HP:0002322)2.97874329
14Ankle contracture (HP:0006466)2.90263946
15Fragile skin (HP:0001030)2.90254693
16Papilledema (HP:0001085)2.88855190
17Osteolytic defects of the hand bones (HP:0009699)2.83270519
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.83270519
19Wormian bones (HP:0002645)2.81349408
20Cerebral aneurysm (HP:0004944)2.77991497
21Depression (HP:0000716)2.75984892
22Short nail (HP:0001799)2.75630183
23Hypercortisolism (HP:0001578)2.73216751
24Pheochromocytoma (HP:0002666)2.65562333
25Agitation (HP:0000713)2.64864471
26Abnormality of the lower motor neuron (HP:0002366)2.62984490
27Hyperinsulinemic hypoglycemia (HP:0000825)2.61703704
28Absence seizures (HP:0002121)2.61529083
29Spinal rigidity (HP:0003306)2.61085439
30Blue sclerae (HP:0000592)2.60147175
31Hypoventilation (HP:0002791)2.56592909
32Flat acetabular roof (HP:0003180)2.52723672
33Achilles tendon contracture (HP:0001771)2.48746418
34Increased connective tissue (HP:0009025)2.48403642
35Epileptic encephalopathy (HP:0200134)2.46556631
36Bowel diverticulosis (HP:0005222)2.45669380
37Thin bony cortex (HP:0002753)2.44083353
38Distal lower limb amyotrophy (HP:0008944)2.41855349
39Abnormality of calcium-phosphate metabolism (HP:0100530)2.40910307
40EEG with generalized epileptiform discharges (HP:0011198)2.40529816
41Epileptiform EEG discharges (HP:0011182)2.39762567
42Hypsarrhythmia (HP:0002521)2.38843819
43Abnormality of the Achilles tendon (HP:0005109)2.37286605
44Asymmetry of the thorax (HP:0001555)2.35787017
45Mitral stenosis (HP:0001718)2.32453876
46Generalized tonic-clonic seizures (HP:0002069)2.32159382
47Elbow flexion contracture (HP:0002987)2.31774166
48Hand muscle atrophy (HP:0009130)2.30316761
49Broad face (HP:0000283)2.30309072
50Distal lower limb muscle weakness (HP:0009053)2.29047078
51Ulnar bowing (HP:0003031)2.24856426
52Ankle clonus (HP:0011448)2.23756223
53Soft skin (HP:0000977)2.23678975
54Abnormality of the acetabulum (HP:0003170)2.22682522
55Abnormality of the distal phalanges of the toes (HP:0010182)2.22391533
56Hypoglycemic seizures (HP:0002173)2.21776358
57Distal upper limb amyotrophy (HP:0007149)2.21267466
58Upper limb amyotrophy (HP:0009129)2.21267466
59Long toe (HP:0010511)2.21073797
60Biconcave vertebral bodies (HP:0004586)2.20323182
61Hyperglycemia (HP:0003074)2.19985673
62Abnormal gallbladder physiology (HP:0012438)2.19596032
63Cholecystitis (HP:0001082)2.19596032
64Anxiety (HP:0000739)2.19456575
65Macroorchidism (HP:0000053)2.19339021
66Insomnia (HP:0100785)2.19016737
67Neuroendocrine neoplasm (HP:0100634)2.17902452
68Cervical subluxation (HP:0003308)2.15233134
69Spinal canal stenosis (HP:0003416)2.12946801
70Genu recurvatum (HP:0002816)2.12469329
71Supranuclear gaze palsy (HP:0000605)2.11404103
72Impaired vibration sensation in the lower limbs (HP:0002166)2.10606918
73Impaired smooth pursuit (HP:0007772)2.10543400
74Follicular hyperkeratosis (HP:0007502)2.09525924
75Dialeptic seizures (HP:0011146)2.09469521
76Action tremor (HP:0002345)2.09342023
77Spondylolisthesis (HP:0003302)2.08389993
78J-shaped sella turcica (HP:0002680)2.08327081
79Premature rupture of membranes (HP:0001788)2.07602647
80Torticollis (HP:0000473)2.07505550
81Bladder diverticulum (HP:0000015)2.07411639
82Abnormality of carpal bone ossification (HP:0006257)2.07346728
83Truncal ataxia (HP:0002078)2.06909558
84Abnormal delivery (HP:0001787)2.06442530
85Abnormality of endocrine pancreas physiology (HP:0012093)2.06175888
86Abnormality of the pancreatic islet cells (HP:0006476)2.06175888
87Impaired pain sensation (HP:0007328)2.06168658
88Abnormality of pain sensation (HP:0010832)2.06168658
89Striae distensae (HP:0001065)2.06021562
90Menstrual irregularities (HP:0000858)2.05620833
91Pointed chin (HP:0000307)2.04759081
92Back pain (HP:0003418)2.04043792
93Enlarged penis (HP:0000040)2.03602982
94Increased variability in muscle fiber diameter (HP:0003557)2.03469232
95Failure to thrive in infancy (HP:0001531)2.01544578
96Joint laxity (HP:0001388)2.01387604
97Impaired social interactions (HP:0000735)1.99915806
98Abnormal social behavior (HP:0012433)1.99915806
99Neoplasm of the heart (HP:0100544)1.99670390
100Progressive cerebellar ataxia (HP:0002073)1.98856131
101Hyperextensible skin (HP:0000974)1.97963986
102Congenital glaucoma (HP:0001087)1.93939709
103Abnormality of liposaccharide metabolism (HP:0010968)1.93748657
104Abnormality of glycosphingolipid metabolism (HP:0004343)1.93748657
105Abnormality of glycolipid metabolism (HP:0010969)1.93748657
106Dilatation of the ascending aorta (HP:0005111)1.93252546
107Hemiplegia (HP:0002301)1.93246099
108Mitral valve prolapse (HP:0001634)1.92852123
109Abnormal ossification of hand bones (HP:0005921)1.92584183
110Dysostosis multiplex (HP:0000943)1.92469184
111Ankyloglossia (HP:0010296)1.92186743
112Symptomatic seizures (HP:0011145)1.91613139
113Poor eye contact (HP:0000817)1.90191566
114Shallow orbits (HP:0000586)1.89972531
115Spinal cord compression (HP:0002176)1.89662519
116Disproportionate tall stature (HP:0001519)1.89211245
117Mitral regurgitation (HP:0001653)1.88917452
118Mildly elevated creatine phosphokinase (HP:0008180)1.88559248
119Deep venous thrombosis (HP:0002625)1.88219921
120Ketoacidosis (HP:0001993)1.86233883
121Natal tooth (HP:0000695)1.85983313
122Focal dystonia (HP:0004373)1.85441912
123Advanced eruption of teeth (HP:0006288)1.83454831
124Trismus (HP:0000211)1.83118162
125Insulin-resistant diabetes mellitus (HP:0000831)1.82656971
126Mucopolysacchariduria (HP:0008155)1.82366473
127Urinary glycosaminoglycan excretion (HP:0003541)1.82366473
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.82057693
129Insidious onset (HP:0003587)1.81518350
130Termporal pattern (HP:0011008)1.81518350
131Vertebral arch anomaly (HP:0008438)1.81402406
132Cardiovascular calcification (HP:0011915)1.81367956
133Neoplasm of the peripheral nervous system (HP:0100007)1.81179195
134Abnormality of dentin (HP:0010299)1.80667590
135Breech presentation (HP:0001623)1.79475748
136Hepatoblastoma (HP:0002884)1.79298850
137Abnormality of skeletal muscle fiber size (HP:0012084)1.78707003
138Overgrowth (HP:0001548)1.78341269
139Febrile seizures (HP:0002373)1.77807537
140Interstitial pulmonary disease (HP:0006530)1.77666923
141Long palpebral fissure (HP:0000637)1.77343362
142Cerebral inclusion bodies (HP:0100314)1.76733261
143Renal duplication (HP:0000075)1.75651399
144Abnormality of oral frenula (HP:0000190)1.75502597
145Hyperacusis (HP:0010780)1.75432288
146Hemorrhage of the eye (HP:0011885)1.74612750
147Hyperparathyroidism (HP:0000843)1.74073399
148Pancreatic islet-cell hyperplasia (HP:0004510)1.74054060
149Craniofacial dystonia (HP:0012179)1.73000311
150Abnormal pancreas size (HP:0012094)1.72027659
151Testicular neoplasm (HP:0010788)1.71215528
152Dysmetric saccades (HP:0000641)1.71078524
153Bradykinesia (HP:0002067)1.70976481
154Lower limb amyotrophy (HP:0007210)1.70651412
155Buphthalmos (HP:0000557)1.69536856
156Thoracolumbar scoliosis (HP:0002944)1.68883069
157Postural instability (HP:0002172)1.68832147
158Myocardial infarction (HP:0001658)1.68582221
159Abnormal eating behavior (HP:0100738)1.68561904
160Aneurysm (HP:0002617)1.68384840
161Coxa vara (HP:0002812)1.68266813
162Neonatal short-limb short stature (HP:0008921)1.67524490
163Nuclear cataract (HP:0100018)1.67348796
164Growth hormone excess (HP:0000845)1.66210061
165Turricephaly (HP:0000262)1.65926825
166Aortic aneurysm (HP:0004942)1.65488130
167Generalized amyotrophy (HP:0003700)1.65477796
168Abnormality of polysaccharide metabolism (HP:0011012)1.64617342
169Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64617342
170Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64617342
171Thin skin (HP:0000963)1.64590127
172Premature skin wrinkling (HP:0100678)1.61059294
173Loss of speech (HP:0002371)1.59120982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.90201794
2MAP3K93.07320816
3EPHA22.94876112
4TRIB32.94670397
5PRKD32.87284881
6MST1R2.61157543
7IRAK32.56101266
8ICK2.56097242
9SMG12.51435011
10MAP3K42.50533821
11MINK12.39823454
12NTRK12.35323035
13EPHA42.31517311
14KSR22.19937098
15PAK42.16703592
16SCYL22.12793398
17FGFR42.11529296
18CAMKK12.09603208
19MAP3K21.96281056
20PDGFRA1.93858371
21PASK1.91975063
22PRPF4B1.90407927
23TTN1.86830884
24PAK61.85089643
25TESK21.67907818
26FER1.65406937
27PKN21.64671570
28CAMKK21.62230731
29FRK1.61763475
30DAPK21.60624951
31INSRR1.57346475
32CDK121.55860341
33MAP2K41.53528501
34NEK11.53527330
35PIM21.52248116
36UHMK11.50559318
37DDR21.50192658
38EPHB11.49935374
39CDC42BPA1.47425456
40RIPK11.46219864
41MAP2K71.46199303
42PAK31.43835746
43PRKCH1.43637214
44KSR11.42594591
45MARK11.37572196
46ARAF1.36986014
47RET1.36093942
48PLK21.35315740
49DAPK11.33759260
50LATS21.30794365
51NEK91.30779025
52NME21.28774976
53MAP3K121.25056803
54CDK51.23323141
55ALK1.16650750
56STK381.16435241
57MYLK1.15617731
58PTK21.11501168
59MTOR1.07755469
60ERN11.06807042
61MAP3K31.06595285
62PAK21.06219306
63TAOK11.04394321
64PRKD21.04349789
65MAP3K11.02060437
66MAPKAPK30.99558832
67PRKCG0.95072169
68HIPK20.91713861
69MAP2K10.89915900
70GRK50.89718523
71NTRK20.89599552
72BRSK10.89105330
73TESK10.88439824
74TAOK20.86778227
75PDK20.82706680
76LMTK20.81817997
77SGK30.79586469
78EIF2AK10.77176159
79TBK10.75400944
80CDK180.75270229
81CDK140.74914246
82PRKG20.74913724
83AKT30.74496707
84CDK150.74241787
85MAP3K60.74050817
86WNK30.73870321
87SIK20.72207004
88SIK10.71921796
89EPHA30.71459466
90LRRK20.69940374
91WNK10.69525630
92PTK60.68959002
93ERBB40.67434850
94TAOK30.67021194
95NEK60.65275315
96TSSK60.63600590
97ILK0.63237477
98CDK60.62571311
99RPS6KA20.62501433
100SIK30.62402447
101TGFBR20.62340812
102MOS0.61911737
103MAP3K80.61546761
104TRPM70.60923642
105EPHB20.60065093
106BMX0.60039670
107CDK11A0.59449017
108MAPK150.58921115
109MAPK110.58802611
110PTK2B0.58751070
111SGK20.56501153
112FLT30.55334754
113CDK70.53268372
114SGK4940.53132903
115SGK2230.53132903
116MAP3K130.53112162
117PDGFRB0.52955219
118FGFR30.52351355
119RPS6KB20.51395578
120MAP3K140.50177994
121LATS10.49637082
122TYRO30.49527381
123CAMK1D0.49383993
124LIMK10.49037352
125PDPK10.48542738
126DAPK30.48220563
127RAF10.47959408
128STK110.47287572
129FGFR10.47199899
130CAMK2A0.46820886
131AKT20.45772741
132BRAF0.45715674
133JAK10.45185740
134PDK10.45022240
135EEF2K0.45016586
136ERBB30.43466775
137RPS6KA30.41951398
138ROCK20.41167449
139PRKCE0.41140534
140CAMK1G0.40845653
141MARK20.40446229
142CDK90.39836209
143CAMK10.39782065
144DYRK1B0.39230614
145CLK10.38737030
146CCNB10.38434433
147PDK40.38219560
148PDK30.38219560
149MET0.38184826
150MAPKAPK20.37302759
151CAMK2B0.37059115
152FES0.36298038
153ZAP700.35899153
154MAPK100.35165458
155ROCK10.34772990
156CDK80.34303627
157CAMK2G0.34189939
158PAK10.33233780
159TYK20.32335983
160MAP2K30.30568573
161PRKD10.30284579

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.10016760
2Other glycan degradation_Homo sapiens_hsa005112.76223467
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.75537302
4Insulin secretion_Homo sapiens_hsa049112.70010666
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42828472
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.36002016
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.30432645
8Amphetamine addiction_Homo sapiens_hsa050312.25697135
9Long-term potentiation_Homo sapiens_hsa047202.16182661
10Circadian entrainment_Homo sapiens_hsa047132.13137200
11GABAergic synapse_Homo sapiens_hsa047272.12883388
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.12611206
13Nicotine addiction_Homo sapiens_hsa050332.12047371
14Vibrio cholerae infection_Homo sapiens_hsa051102.08732848
15Dopaminergic synapse_Homo sapiens_hsa047281.96436571
16Olfactory transduction_Homo sapiens_hsa047401.96266394
17Cocaine addiction_Homo sapiens_hsa050301.92464754
18Pentose phosphate pathway_Homo sapiens_hsa000301.90195119
19Fructose and mannose metabolism_Homo sapiens_hsa000511.90018507
20Type II diabetes mellitus_Homo sapiens_hsa049301.79284100
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78852883
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74730999
23Galactose metabolism_Homo sapiens_hsa000521.73212824
24Morphine addiction_Homo sapiens_hsa050321.71959587
25Biosynthesis of amino acids_Homo sapiens_hsa012301.71593489
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66744468
27Cholinergic synapse_Homo sapiens_hsa047251.60431235
28Gastric acid secretion_Homo sapiens_hsa049711.57046514
29Glutamatergic synapse_Homo sapiens_hsa047241.53472403
30Chronic myeloid leukemia_Homo sapiens_hsa052201.53262456
31Salivary secretion_Homo sapiens_hsa049701.49478233
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48760608
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44361419
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42842213
35Collecting duct acid secretion_Homo sapiens_hsa049661.39750017
36Estrogen signaling pathway_Homo sapiens_hsa049151.37916185
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34087303
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.30973865
39Renin secretion_Homo sapiens_hsa049241.29582446
40Carbon metabolism_Homo sapiens_hsa012001.29484593
41Amoebiasis_Homo sapiens_hsa051461.29479606
42Thyroid hormone synthesis_Homo sapiens_hsa049181.28784275
43Small cell lung cancer_Homo sapiens_hsa052221.28488444
44Gap junction_Homo sapiens_hsa045401.26792507
45Taste transduction_Homo sapiens_hsa047421.26158709
46Long-term depression_Homo sapiens_hsa047301.20300064
47GnRH signaling pathway_Homo sapiens_hsa049121.20120817
48Glioma_Homo sapiens_hsa052141.19119748
49Oxytocin signaling pathway_Homo sapiens_hsa049211.19105311
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19034326
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18169351
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16420511
53Adherens junction_Homo sapiens_hsa045201.15833836
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15618905
55Pancreatic cancer_Homo sapiens_hsa052121.14685490
56Type I diabetes mellitus_Homo sapiens_hsa049401.13159162
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11948352
58Glucagon signaling pathway_Homo sapiens_hsa049221.09053231
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08470586
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08088473
61Fatty acid biosynthesis_Homo sapiens_hsa000611.06101012
62Arginine biosynthesis_Homo sapiens_hsa002201.03706144
63Pancreatic secretion_Homo sapiens_hsa049721.03610897
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03336629
65Serotonergic synapse_Homo sapiens_hsa047261.01821299
66Acute myeloid leukemia_Homo sapiens_hsa052211.01327186
67cAMP signaling pathway_Homo sapiens_hsa040241.01137307
68Shigellosis_Homo sapiens_hsa051311.00343013
69Melanogenesis_Homo sapiens_hsa049161.00075618
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98603389
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96673363
72Calcium signaling pathway_Homo sapiens_hsa040200.95743478
73N-Glycan biosynthesis_Homo sapiens_hsa005100.92123699
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.91658940
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.91541591
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91179944
77mTOR signaling pathway_Homo sapiens_hsa041500.90931987
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90208152
79Renin-angiotensin system_Homo sapiens_hsa046140.89792567
80Sphingolipid metabolism_Homo sapiens_hsa006000.86024987
81Notch signaling pathway_Homo sapiens_hsa043300.85938224
82Phenylalanine metabolism_Homo sapiens_hsa003600.85289620
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84422784
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.83535049
85Prostate cancer_Homo sapiens_hsa052150.83105345
86Salmonella infection_Homo sapiens_hsa051320.82671318
87Dilated cardiomyopathy_Homo sapiens_hsa054140.82521420
88AMPK signaling pathway_Homo sapiens_hsa041520.81719622
89Hepatitis C_Homo sapiens_hsa051600.80864260
90Oocyte meiosis_Homo sapiens_hsa041140.78660276
91ErbB signaling pathway_Homo sapiens_hsa040120.78449106
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78084752
93Complement and coagulation cascades_Homo sapiens_hsa046100.75521721
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74813251
95Nitrogen metabolism_Homo sapiens_hsa009100.74087913
96Insulin signaling pathway_Homo sapiens_hsa049100.72803760
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.72332883
98Steroid biosynthesis_Homo sapiens_hsa001000.71044674
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70077317
100Protein digestion and absorption_Homo sapiens_hsa049740.69063809
101Endometrial cancer_Homo sapiens_hsa052130.68293032
102MicroRNAs in cancer_Homo sapiens_hsa052060.67776312
103Apoptosis_Homo sapiens_hsa042100.67014743
104Hepatitis B_Homo sapiens_hsa051610.65868333
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65244721
106Focal adhesion_Homo sapiens_hsa045100.63641290
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63230045
108HIF-1 signaling pathway_Homo sapiens_hsa040660.62897659
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62708935
110Prion diseases_Homo sapiens_hsa050200.62269170
111Tight junction_Homo sapiens_hsa045300.62207400
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62116344
113Inositol phosphate metabolism_Homo sapiens_hsa005620.62098840
114Protein export_Homo sapiens_hsa030600.61471985
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61149971
116Fatty acid metabolism_Homo sapiens_hsa012120.60866465
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60267211
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59429594
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58568697
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56952121
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56837476
122PPAR signaling pathway_Homo sapiens_hsa033200.56711109
123Bladder cancer_Homo sapiens_hsa052190.55034666
124Non-small cell lung cancer_Homo sapiens_hsa052230.54867860
125Insulin resistance_Homo sapiens_hsa049310.54624262
126Fatty acid elongation_Homo sapiens_hsa000620.54571373
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.54419090
128Phagosome_Homo sapiens_hsa041450.54364789
129Rap1 signaling pathway_Homo sapiens_hsa040150.53415403
130Alcoholism_Homo sapiens_hsa050340.52478625
131Viral carcinogenesis_Homo sapiens_hsa052030.51973447
132MAPK signaling pathway_Homo sapiens_hsa040100.51382265
133Endocytosis_Homo sapiens_hsa041440.50852166
134Vitamin B6 metabolism_Homo sapiens_hsa007500.50752216
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50614267
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.49870662
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49850500
138Toxoplasmosis_Homo sapiens_hsa051450.49640382
139Prolactin signaling pathway_Homo sapiens_hsa049170.49480705
140TNF signaling pathway_Homo sapiens_hsa046680.49440729
141Sulfur metabolism_Homo sapiens_hsa009200.49194600
142Proteoglycans in cancer_Homo sapiens_hsa052050.48835243
1432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48480037
144VEGF signaling pathway_Homo sapiens_hsa043700.48318516
145Lysosome_Homo sapiens_hsa041420.47922795
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.47826711
147Arginine and proline metabolism_Homo sapiens_hsa003300.46380531
148Colorectal cancer_Homo sapiens_hsa052100.43655910
149Axon guidance_Homo sapiens_hsa043600.43351915
150Bile secretion_Homo sapiens_hsa049760.43078085
151Circadian rhythm_Homo sapiens_hsa047100.42722210
152Tyrosine metabolism_Homo sapiens_hsa003500.42693952
153Thyroid cancer_Homo sapiens_hsa052160.41270542
154Renal cell carcinoma_Homo sapiens_hsa052110.40637108
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40513089
156Dorso-ventral axis formation_Homo sapiens_hsa043200.38134921
157ECM-receptor interaction_Homo sapiens_hsa045120.37622247

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