COPB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* Golgi transport vesicle coating (GO:0048200)9.68132456
2* COPI coating of Golgi vesicle (GO:0048205)9.68132456
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.67578014
4COPII vesicle coating (GO:0048208)6.05974221
5protein retention in ER lumen (GO:0006621)5.79691160
6activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.47118280
7* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.42454212
8positive regulation of nuclease activity (GO:0032075)5.28777236
9regulation of nuclease activity (GO:0032069)4.82792592
10endoplasmic reticulum unfolded protein response (GO:0030968)4.76387284
11cellular response to unfolded protein (GO:0034620)4.60504698
12* vesicle coating (GO:0006901)4.58641713
13ER-nucleus signaling pathway (GO:0006984)4.42580050
14cellular response to topologically incorrect protein (GO:0035967)4.33765207
154-hydroxyproline metabolic process (GO:0019471)4.05311717
16ribosome assembly (GO:0042255)3.97233644
17exocrine pancreas development (GO:0031017)3.92012413
18response to endoplasmic reticulum stress (GO:0034976)3.79384827
19sequestering of metal ion (GO:0051238)3.74290177
20UDP-N-acetylglucosamine metabolic process (GO:0006047)3.70369870
21response to unfolded protein (GO:0006986)3.58411179
22protein maturation by protein folding (GO:0022417)3.52032854
23peptidyl-proline hydroxylation (GO:0019511)3.46166649
24response to topologically incorrect protein (GO:0035966)3.42238403
25endocrine pancreas development (GO:0031018)3.40472201
26folic acid-containing compound biosynthetic process (GO:0009396)3.37500930
27cellular response to vitamin D (GO:0071305)3.28126415
28ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.24796158
29peptidyl-asparagine modification (GO:0018196)3.24780957
30protein N-linked glycosylation via asparagine (GO:0018279)3.24151243
31protein hydroxylation (GO:0018126)3.23560396
32positive regulation of hormone biosynthetic process (GO:0046886)3.22013377
33tRNA aminoacylation for protein translation (GO:0006418)3.19193969
34desmosome organization (GO:0002934)3.18502685
35sequestering of extracellular ligand from receptor (GO:0035581)3.13249727
36protein N-linked glycosylation (GO:0006487)3.11035396
37negative regulation of fatty acid transport (GO:2000192)3.10549211
38collagen fibril organization (GO:0030199)3.10474822
39tRNA aminoacylation (GO:0043039)3.07789855
40amino acid activation (GO:0043038)3.07789855
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02353542
42oocyte development (GO:0048599)3.01799004
43establishment of integrated proviral latency (GO:0075713)3.00744781
44ER overload response (GO:0006983)3.00229767
45iron ion import (GO:0097286)2.98659266
46regulation of mitotic spindle organization (GO:0060236)2.98623656
47bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97285918
48cellular response to vitamin (GO:0071295)2.92770673
49type B pancreatic cell development (GO:0003323)2.91951743
50ER to Golgi vesicle-mediated transport (GO:0006888)2.91020244
51apoptotic cell clearance (GO:0043277)2.90762203
52pore complex assembly (GO:0046931)2.90460697
53intestinal cholesterol absorption (GO:0030299)2.90181181
54glucocorticoid receptor signaling pathway (GO:0042921)2.89804857
55peptide hormone processing (GO:0016486)2.89134354
56nuclear pore complex assembly (GO:0051292)2.87095559
57proteasome assembly (GO:0043248)2.86467393
58intestinal absorption (GO:0050892)2.85784968
59L-alpha-amino acid transmembrane transport (GO:1902475)2.85554514
60Golgi organization (GO:0007030)2.83857482
61nuclear pore organization (GO:0006999)2.83691959
62mitotic sister chromatid cohesion (GO:0007064)2.82727535
63ventricular cardiac muscle cell development (GO:0055015)2.81916954
64cellular response to glucose starvation (GO:0042149)2.80864601
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80790379
66mitotic metaphase plate congression (GO:0007080)2.78537296
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.76305180
68glandular epithelial cell differentiation (GO:0002067)2.73906862
69skin morphogenesis (GO:0043589)2.73533240
70establishment of chromosome localization (GO:0051303)2.72380521
71signal peptide processing (GO:0006465)2.72224001
72establishment of viral latency (GO:0019043)2.70968651
73regulation of centriole replication (GO:0046599)2.70463776
74tricarboxylic acid cycle (GO:0006099)2.69943911
75peptide catabolic process (GO:0043171)2.69371979
76mitotic sister chromatid segregation (GO:0000070)2.69120004
77sister chromatid segregation (GO:0000819)2.68355314
78glandular epithelial cell development (GO:0002068)2.67693935
79hormone catabolic process (GO:0042447)2.67228908
80metaphase plate congression (GO:0051310)2.67044322
81tricarboxylic acid metabolic process (GO:0072350)2.66559827
82dorsal/ventral axis specification (GO:0009950)2.65483939
83regulation of glucose import in response to insulin stimulus (GO:2001273)2.63376066
84protein autoprocessing (GO:0016540)2.61927253
85double-strand break repair via nonhomologous end joining (GO:0006303)2.61746383
86non-recombinational repair (GO:0000726)2.61746383
87regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.61102052
88nucleotide-sugar metabolic process (GO:0009225)2.60406836
89nucleotide-sugar biosynthetic process (GO:0009226)2.59599037
90regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.59312747
91negative regulation of keratinocyte proliferation (GO:0010839)2.58191035
92negative regulation of DNA repair (GO:0045738)2.56699625
93proline biosynthetic process (GO:0006561)2.55391154
94regulation of translational fidelity (GO:0006450)2.54782561
95gland morphogenesis (GO:0022612)2.54344857
96negative regulation of chondrocyte differentiation (GO:0032331)2.52755327
97regulation of transforming growth factor beta2 production (GO:0032909)2.52412250
98regulation of type B pancreatic cell apoptotic process (GO:2000674)2.51653019
99regulation of protein heterodimerization activity (GO:0043497)2.51248981
100negative regulation of cartilage development (GO:0061037)2.51221564
101protein localization to kinetochore (GO:0034501)2.50828340
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50319672
103regulation of spindle organization (GO:0090224)2.49531818
104keratan sulfate catabolic process (GO:0042340)2.49372075
105cullin deneddylation (GO:0010388)2.48502154
106lysine catabolic process (GO:0006554)2.45056170
107lysine metabolic process (GO:0006553)2.45056170
108columnar/cuboidal epithelial cell development (GO:0002066)2.42302070
109maternal placenta development (GO:0001893)2.42266027
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.40906922
111protein carboxylation (GO:0018214)2.40141229
112peptidyl-glutamic acid carboxylation (GO:0017187)2.40141229
113toxin metabolic process (GO:0009404)2.37909530
114anterior/posterior axis specification, embryo (GO:0008595)2.37286447
115chondrocyte development (GO:0002063)2.36367586
116chaperone-mediated protein folding (GO:0061077)2.36103815
117protein deneddylation (GO:0000338)2.33809719
118positive regulation of glycolytic process (GO:0045821)2.33736399
119intestinal epithelial cell development (GO:0060576)2.33486807
120cell adhesion mediated by integrin (GO:0033627)2.33434941
121retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32620609
122low-density lipoprotein particle clearance (GO:0034383)2.32567091
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.32377850
124regulation of cholesterol homeostasis (GO:2000188)2.32193781
125protein localization to chromosome, centromeric region (GO:0071459)2.30831350
126corticosteroid receptor signaling pathway (GO:0031958)2.30447290
127cytoskeleton-dependent cytokinesis (GO:0061640)2.28995681
128endodermal cell differentiation (GO:0035987)2.28873682
129positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.28413199
130tetrahydrofolate metabolic process (GO:0046653)2.28241769
131zinc ion transport (GO:0006829)2.27559328
132positive regulation of SMAD protein import into nucleus (GO:0060391)2.27100798
133cellular response to nutrient (GO:0031670)2.26968382
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.26752354
135regulation of fatty acid beta-oxidation (GO:0031998)2.26675149
136response to X-ray (GO:0010165)2.25640269
137macroautophagy (GO:0016236)2.25225827
138positive regulation of protein autophosphorylation (GO:0031954)2.24645410
139midgut development (GO:0007494)2.24022057
140polarized epithelial cell differentiation (GO:0030859)2.23880976
141gap junction assembly (GO:0016264)2.23793037
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.23601007
143hemidesmosome assembly (GO:0031581)2.23217423
144formation of translation preinitiation complex (GO:0001731)2.23191443
145cellular zinc ion homeostasis (GO:0006882)2.22984413
146spindle assembly involved in mitosis (GO:0090307)2.22393639
147chondrocyte proliferation (GO:0035988)2.22281281
148negative regulation of glycogen biosynthetic process (GO:0045719)2.22246147
149negative regulation of fibrinolysis (GO:0051918)2.22104762
150mitotic cytokinesis (GO:0000281)2.20730046
151mitotic nuclear envelope disassembly (GO:0007077)2.20657809
152regulation of cardioblast differentiation (GO:0051890)2.19807677
153regulation of cellular amino acid metabolic process (GO:0006521)2.19740678
154negative regulation of protein activation cascade (GO:2000258)2.19178688
155hippo signaling (GO:0035329)2.18753325
156maintenance of protein localization in organelle (GO:0072595)2.17712811
157NLS-bearing protein import into nucleus (GO:0006607)2.16320310
158lung vasculature development (GO:0060426)2.15734509
159dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.11227151
160lipid particle organization (GO:0034389)2.11017224
161nucleobase-containing small molecule interconversion (GO:0015949)2.10935341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.10025618
2CLOCK_20551151_ChIP-Seq_293T_Human3.90258180
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.61533239
4E2F7_22180533_ChIP-Seq_HELA_Human3.53767984
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.53685682
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08327635
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.08113929
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06974242
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.92765672
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68830646
11GATA1_22025678_ChIP-Seq_K562_Human2.68727218
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.60817408
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.56292417
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.54771494
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.39021365
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28497165
17AR_21909140_ChIP-Seq_LNCAP_Human2.25766599
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.24949330
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23538408
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22260412
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09228836
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08287919
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.05749441
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97632318
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94878057
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87473075
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.87463798
28TFEB_21752829_ChIP-Seq_HELA_Human1.81459044
29DCP1A_22483619_ChIP-Seq_HELA_Human1.79696504
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78777082
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.77341909
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.69605482
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.67807716
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67665392
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66215349
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65302053
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64675869
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63812329
39CHD1_26751641_Chip-Seq_LNCaP_Human1.62408991
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.60786592
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59918585
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58639997
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57372490
44MYC_22102868_ChIP-Seq_BL_Human1.56149734
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55263189
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55221033
47BRD4_25478319_ChIP-Seq_HGPS_Human1.55069538
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54385275
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.50224095
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50126366
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49780666
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49593405
53ATF3_27146783_Chip-Seq_COLON_Human1.48384706
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47210526
55FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.46751202
56* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46644329
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46342040
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45568405
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44882180
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.41161552
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40343210
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39687625
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38241515
64NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.37548399
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35661884
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34841026
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34227097
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.33502897
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.31066508
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29689669
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29689669
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29637378
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29333863
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28890803
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.28132303
76* GATA4_25053715_ChIP-Seq_YYC3_Human1.26882383
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26659664
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26126590
79GATA6_25053715_ChIP-Seq_YYC3_Human1.25636231
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25197745
81CJUN_26792858_Chip-Seq_BT549_Human1.24876140
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24645544
83ELK1_19687146_ChIP-ChIP_HELA_Human1.23614695
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.23171138
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21872660
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20809967
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19125252
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.17078539
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15978911
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15891734
91SOX2_20726797_ChIP-Seq_SW620_Human1.15077424
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.14579273
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12517500
94GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12345218
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.11857851
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11605785
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10824950
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10170058
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.10038791
100EOMES_21245162_ChIP-Seq_HESCs_Human1.09605093
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.09570610
102* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09173517
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08893984
104* GABP_19822575_ChIP-Seq_HepG2_Human1.08172295
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06911071
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06453395
107FOXA2_19822575_ChIP-Seq_HepG2_Human1.04974470
108* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04915759
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04891584
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04891584
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04237685
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.04219421
113* ELK1_22589737_ChIP-Seq_MCF10A_Human1.04037672
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01064872
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00664271
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00601827
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00401947
118ZNF263_19887448_ChIP-Seq_K562_Human0.99809239
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99204302
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99068524
121* ELF5_23300383_ChIP-Seq_T47D_Human0.99003463
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98885434
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98781288
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98210986
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98168842
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98012018
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97834822
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97595446
129* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97239193
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96401729
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96246406
132VDR_23849224_ChIP-Seq_CD4+_Human0.96102500
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94494090
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94245954
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.93840831
136KDM5A_27292631_Chip-Seq_BREAST_Human0.93308225
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92647246
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.92591285
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92506708
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92125217
141NCOR1_26117541_ChIP-Seq_K562_Human0.91314178
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91233802
143ESR2_21235772_ChIP-Seq_MCF-7_Human0.90785584
144FUS_26573619_Chip-Seq_HEK293_Human0.89764721
145* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89475807
146CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88444032
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88215744
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.87556100
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87439276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.83836953
2MP0003705_abnormal_hypodermis_morpholog3.57073064
3MP0002877_abnormal_melanocyte_morpholog3.47656397
4MP0003941_abnormal_skin_development3.35782925
5MP0003950_abnormal_plasma_membrane3.10426590
6MP0006054_spinal_hemorrhage2.86617584
7MP0003283_abnormal_digestive_organ2.54595075
8MP0010352_gastrointestinal_tract_polyps2.48136461
9MP0005275_abnormal_skin_tensile2.40038341
10MP0002139_abnormal_hepatobiliary_system2.35238048
11MP0009780_abnormal_chondrocyte_physiolo2.07836084
12MP0005220_abnormal_exocrine_pancreas2.01692138
13MP0005503_abnormal_tendon_morphology2.00025020
14MP0003300_gastrointestinal_ulcer1.99045381
15MP0004264_abnormal_extraembryonic_tissu1.96069667
16MP0005076_abnormal_cell_differentiation1.95156587
17MP0002896_abnormal_bone_mineralization1.94562468
18MP0005365_abnormal_bile_salt1.91188341
19MP0003566_abnormal_cell_adhesion1.86771514
20MP0010234_abnormal_vibrissa_follicle1.86100028
21MP0003195_calcinosis1.86023982
22MP0000013_abnormal_adipose_tissue1.83142769
23MP0008932_abnormal_embryonic_tissue1.81337461
24MP0004272_abnormal_basement_membrane1.78940950
25MP0003252_abnormal_bile_duct1.77217750
26MP0003806_abnormal_nucleotide_metabolis1.75893283
27MP0001944_abnormal_pancreas_morphology1.67780048
28MP0008007_abnormal_cellular_replicative1.64330021
29MP0002909_abnormal_adrenal_gland1.63078899
30MP0010094_abnormal_chromosome_stability1.62598240
31MP0005360_urolithiasis1.54299800
32MP0001666_abnormal_nutrient_absorption1.46311747
33MP0005408_hypopigmentation1.45320326
34MP0005023_abnormal_wound_healing1.42779940
35MP0003111_abnormal_nucleus_morphology1.42496492
36MP0009384_cardiac_valve_regurgitation1.42232045
37MP0003937_abnormal_limbs/digits/tail_de1.42102819
38MP0003077_abnormal_cell_cycle1.41234875
39MP0001348_abnormal_lacrimal_gland1.41040619
40MP0008058_abnormal_DNA_repair1.39601516
41MP0005085_abnormal_gallbladder_physiolo1.38817285
42MP0002254_reproductive_system_inflammat1.36361967
43MP0002693_abnormal_pancreas_physiology1.34099498
44MP0009697_abnormal_copulation1.33875026
45MP0000537_abnormal_urethra_morphology1.33079084
46MP0001661_extended_life_span1.30161985
47MP0009053_abnormal_anal_canal1.27480510
48MP0002168_other_aberrant_phenotype1.27123505
49MP0004147_increased_porphyrin_level1.24465524
50MP0010030_abnormal_orbit_morphology1.23802958
51MP0000003_abnormal_adipose_tissue1.22143191
52MP0001849_ear_inflammation1.21575367
53MP0002060_abnormal_skin_morphology1.19900962
54MP0003123_paternal_imprinting1.19496711
55MP0003868_abnormal_feces_composition1.18294491
56MP0010678_abnormal_skin_adnexa1.12447019
57MP0000428_abnormal_craniofacial_morphol1.12001731
58MP0004197_abnormal_fetal_growth/weight/1.10803539
59MP0001697_abnormal_embryo_size1.08740551
60MP0003385_abnormal_body_wall1.08554332
61MP0003718_maternal_effect1.08428090
62MP0000427_abnormal_hair_cycle1.07167963
63MP0010307_abnormal_tumor_latency1.05751076
64MP0000163_abnormal_cartilage_morphology1.03973567
65MP0003942_abnormal_urinary_system1.03961470
66MP0003279_aneurysm1.03799282
67MP0003183_abnormal_peptide_metabolism1.02938118
68MP0008057_abnormal_DNA_replication1.02780850
69MP0005257_abnormal_intraocular_pressure1.02696512
70MP0000678_abnormal_parathyroid_gland1.02218420
71MP0003890_abnormal_embryonic-extraembry1.01637500
72MP0005083_abnormal_biliary_tract1.01194827
73MP0000762_abnormal_tongue_morphology0.99719137
74MP0002085_abnormal_embryonic_tissue0.99531685
75MP0000647_abnormal_sebaceous_gland0.97276233
76MP0009643_abnormal_urine_homeostasis0.95874566
77MP0002080_prenatal_lethality0.95752928
78MP0003091_abnormal_cell_migration0.95727662
79MP0005508_abnormal_skeleton_morphology0.95186150
80MP0002928_abnormal_bile_duct0.95150901
81MP0001881_abnormal_mammary_gland0.94496718
82MP0003191_abnormal_cellular_cholesterol0.94389914
83MP0002115_abnormal_skeleton_extremities0.93072529
84MP0004043_abnormal_pH_regulation0.92944008
85MP0002078_abnormal_glucose_homeostasis0.92272438
86MP0009672_abnormal_birth_weight0.92195719
87MP0000350_abnormal_cell_proliferation0.92033721
88MP0000627_abnormal_mammary_gland0.91527153
89MP0001299_abnormal_eye_distance/0.91526167
90MP0010329_abnormal_lipoprotein_level0.89424684
91MP0000767_abnormal_smooth_muscle0.89141165
92MP0001958_emphysema0.89058502
93MP0005623_abnormal_meninges_morphology0.88630964
94MP0003755_abnormal_palate_morphology0.87639833
95MP0009840_abnormal_foam_cell0.87525032
96MP0002138_abnormal_hepatobiliary_system0.87507601
97MP0003795_abnormal_bone_structure0.87051545
98MP0005395_other_phenotype0.86856844
99MP0003786_premature_aging0.86156869
100MP0001243_abnormal_dermal_layer0.86153347
101MP0003119_abnormal_digestive_system0.85884005
102MP0002933_joint_inflammation0.85356791
103MP0010386_abnormal_urinary_bladder0.85328947
104MP0005187_abnormal_penis_morphology0.85094796
105MP0004957_abnormal_blastocyst_morpholog0.84640350
106MP0010368_abnormal_lymphatic_system0.84639593
107MP0001730_embryonic_growth_arrest0.83826886
108MP0000462_abnormal_digestive_system0.83617278
109MP0002697_abnormal_eye_size0.82797028
110MP0005197_abnormal_uvea_morphology0.82586656
111MP0002295_abnormal_pulmonary_circulatio0.80978622
112MP0005248_abnormal_Harderian_gland0.80533019
113MP0001216_abnormal_epidermal_layer0.80309662
114MP0002938_white_spotting0.80299142
115MP0003935_abnormal_craniofacial_develop0.80260860
116MP0003115_abnormal_respiratory_system0.80148742
117MP0000609_abnormal_liver_physiology0.80148516
118MP0002086_abnormal_extraembryonic_tissu0.80067962
119MP0000358_abnormal_cell_content/0.79420179
120MP0000432_abnormal_head_morphology0.78651107
121MP0002837_dystrophic_cardiac_calcinosis0.77641940
122MP0000377_abnormal_hair_follicle0.77505920
123MP0003693_abnormal_embryo_hatching0.76996735
124MP0002234_abnormal_pharynx_morphology0.76916406
125MP0002088_abnormal_embryonic_growth/wei0.76266521
126MP0000467_abnormal_esophagus_morphology0.76183881
127MP0001756_abnormal_urination0.75932553
128MP0005375_adipose_tissue_phenotype0.75849901
129MP0003984_embryonic_growth_retardation0.75693114
130MP0002084_abnormal_developmental_patter0.75688542
131MP0005501_abnormal_skin_physiology0.75340542
132MP0002233_abnormal_nose_morphology0.75092766
133MP0004782_abnormal_surfactant_physiolog0.75080022
134MP0005171_absent_coat_pigmentation0.74907747
135MP0000534_abnormal_ureter_morphology0.74856886
136MP0001915_intracranial_hemorrhage0.74795219
137MP0005621_abnormal_cell_physiology0.73871086
138MP0002089_abnormal_postnatal_growth/wei0.72956749
139MP0000569_abnormal_digit_pigmentation0.72804978
140MP0004233_abnormal_muscle_weight0.72424908
141MP0000598_abnormal_liver_morphology0.72342537
142MP0009703_decreased_birth_body0.72084762
143MP0002113_abnormal_skeleton_development0.71945281
144MP0001542_abnormal_bone_strength0.71577357
145MP0003045_fibrosis0.71179409
146MP0005380_embryogenesis_phenotype0.70682246
147MP0001672_abnormal_embryogenesis/_devel0.70682246
148MP0002282_abnormal_trachea_morphology0.70427462
149MP0000383_abnormal_hair_follicle0.69969377
150MP0000613_abnormal_salivary_gland0.69816503
151MP0004185_abnormal_adipocyte_glucose0.69404206

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.46405002
2Hypoglycemic coma (HP:0001325)3.95693123
3Hyperinsulinemic hypoglycemia (HP:0000825)3.66077156
4Premature rupture of membranes (HP:0001788)3.61316981
5Cervical subluxation (HP:0003308)3.55399224
6Hypoglycemic seizures (HP:0002173)3.44488054
7Follicular hyperkeratosis (HP:0007502)3.30101705
8Hyperglycemia (HP:0003074)3.05710126
9Vascular tortuosity (HP:0004948)3.05557329
10Ankle contracture (HP:0006466)2.96330586
11Arterial tortuosity (HP:0005116)2.93707783
12Abnormality of the intrinsic pathway (HP:0010989)2.87531821
13Metaphyseal cupping (HP:0003021)2.85290237
14Selective tooth agenesis (HP:0001592)2.82721800
15Abnormality of endocrine pancreas physiology (HP:0012093)2.80356389
16Abnormality of the pancreatic islet cells (HP:0006476)2.80356389
17Symptomatic seizures (HP:0011145)2.71350694
18Cerebral aneurysm (HP:0004944)2.67060137
19Abnormal delivery (HP:0001787)2.64578540
20Abnormality of glycolysis (HP:0004366)2.58797169
21Osteolytic defects of the hand bones (HP:0009699)2.58245515
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.58245515
23Late onset (HP:0003584)2.56217289
24Aortic aneurysm (HP:0004942)2.54098446
25Pancreatic islet-cell hyperplasia (HP:0004510)2.50541449
26Abnormal foot bone ossification (HP:0010675)2.48923693
27Increased serum pyruvate (HP:0003542)2.48341514
28Ketoacidosis (HP:0001993)2.47740521
29Insulin-resistant diabetes mellitus (HP:0000831)2.47148824
30Thoracolumbar scoliosis (HP:0002944)2.47124310
31Atrophic scars (HP:0001075)2.45005656
32Aortic dissection (HP:0002647)2.38296211
33Abnormality of the common coagulation pathway (HP:0010990)2.36434593
34Subacute progressive viral hepatitis (HP:0006572)2.35917474
35Cardiovascular calcification (HP:0011915)2.30987027
36Hypoplastic ischia (HP:0003175)2.30203338
37Wormian bones (HP:0002645)2.30200063
38Hypobetalipoproteinemia (HP:0003563)2.29676665
39Shallow orbits (HP:0000586)2.29435111
40Mucopolysacchariduria (HP:0008155)2.28173291
41Urinary glycosaminoglycan excretion (HP:0003541)2.28173291
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28125738
43Cupped ribs (HP:0000887)2.27665563
44Aneurysm (HP:0002617)2.27578321
45Papillary thyroid carcinoma (HP:0002895)2.25868988
46Abnormal pancreas size (HP:0012094)2.22705177
47Dilatation of the ascending aorta (HP:0005111)2.22208697
48Abnormality of methionine metabolism (HP:0010901)2.20434538
49Hand muscle atrophy (HP:0009130)2.19514588
50Back pain (HP:0003418)2.19117027
51Hypolipoproteinemia (HP:0010981)2.18611726
52Blue sclerae (HP:0000592)2.16465979
53Platyspondyly (HP:0000926)2.15646444
54Protuberant abdomen (HP:0001538)2.13869824
55Rhabdomyosarcoma (HP:0002859)2.12838648
56Abnormality of the ischium (HP:0003174)2.12764791
57Soft skin (HP:0000977)2.11488883
58Vertebral compression fractures (HP:0002953)2.10949170
59Proximal tubulopathy (HP:0000114)2.10723963
60Exostoses (HP:0100777)2.09516852
61Epiphyseal dysplasia (HP:0002656)2.09029845
62Abnormal cartilage morphology (HP:0002763)2.07034084
63Mitral valve prolapse (HP:0001634)2.06790199
64Severe short stature (HP:0003510)2.05999370
65Microglossia (HP:0000171)2.02093844
66Abnormality of the acetabulum (HP:0003170)2.00775651
67Abnormal tarsal ossification (HP:0008369)2.00399444
68Overlapping toe (HP:0001845)1.99773879
69Abdominal distention (HP:0003270)1.99405019
70Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98937033
71Intrahepatic cholestasis (HP:0001406)1.97898224
72Missing ribs (HP:0000921)1.97594702
73Mildly elevated creatine phosphokinase (HP:0008180)1.97560565
74Abnormality of polysaccharide metabolism (HP:0011012)1.97498592
75Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97498592
76Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97498592
77Abnormality of the distal phalanges of the toes (HP:0010182)1.97374351
78Mitral stenosis (HP:0001718)1.97161301
79Abnormal biliary tract morphology (HP:0012440)1.95487011
80Natal tooth (HP:0000695)1.95341721
81Redundant skin (HP:0001582)1.95101121
82Insulin resistance (HP:0000855)1.93424148
83Long toe (HP:0010511)1.93269348
84Thin bony cortex (HP:0002753)1.93142747
85Entropion (HP:0000621)1.92570371
86Abnormality of the umbilical cord (HP:0010881)1.91552989
87Deep philtrum (HP:0002002)1.90158802
88Bladder diverticulum (HP:0000015)1.90144861
89Spastic diplegia (HP:0001264)1.88398353
90Skin nodule (HP:0200036)1.87621926
91Asymmetry of the thorax (HP:0001555)1.87316133
92Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86491916
93Vertebral hypoplasia (HP:0008417)1.86491916
94Flat acetabular roof (HP:0003180)1.86359853
95Vascular calcification (HP:0004934)1.85626276
96Breech presentation (HP:0001623)1.84954794
97Peritonitis (HP:0002586)1.84651517
98Lymphangioma (HP:0100764)1.83914869
99Genu recurvatum (HP:0002816)1.83803273
100Generalized aminoaciduria (HP:0002909)1.83494129
101Secondary amenorrhea (HP:0000869)1.82783097
102Biliary tract neoplasm (HP:0100574)1.82717518
103Orthostatic hypotension (HP:0001278)1.82256730
104Hypoalphalipoproteinemia (HP:0003233)1.79850417
105Beaking of vertebral bodies (HP:0004568)1.79244211
106Abnormal protein glycosylation (HP:0012346)1.78916037
107Abnormal glycosylation (HP:0012345)1.78916037
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78916037
109Abnormal protein N-linked glycosylation (HP:0012347)1.78916037
110Right ventricular cardiomyopathy (HP:0011663)1.75537158
111Fragile skin (HP:0001030)1.75338202
112Deep venous thrombosis (HP:0002625)1.75316522
113Radial bowing (HP:0002986)1.74693660
114Abnormality of carpal bone ossification (HP:0006257)1.74482907
115Rectal prolapse (HP:0002035)1.73906648
116Short nail (HP:0001799)1.72830561
117Abnormalities of placenta or umbilical cord (HP:0001194)1.72765171
118Tetraparesis (HP:0002273)1.72653829
119Abnormality of the fetal cardiovascular system (HP:0010948)1.71133615
120Abnormal umbilical cord blood vessels (HP:0011403)1.71133615
121Single umbilical artery (HP:0001195)1.71133615
122Increased nuchal translucency (HP:0010880)1.71110956
123Abnormality of the calcaneus (HP:0008364)1.70992514
124Hepatoblastoma (HP:0002884)1.70465643
125Abnormality of dentin (HP:0010299)1.70255986
126Thyroid carcinoma (HP:0002890)1.70131215
127Pterygium (HP:0001059)1.70071993
128Elbow flexion contracture (HP:0002987)1.69883968
129Upper limb amyotrophy (HP:0009129)1.69620166
130Distal upper limb amyotrophy (HP:0007149)1.69620166
131Osteoarthritis (HP:0002758)1.69047456
132Delayed closure of the anterior fontanelle (HP:0001476)1.68687808
133Ketosis (HP:0001946)1.68444913
134Nonimmune hydrops fetalis (HP:0001790)1.68230412
135Increased connective tissue (HP:0009025)1.68063302
136Mesomelia (HP:0003027)1.67851541
137Xanthomatosis (HP:0000991)1.67687391
138Abnormal vertebral ossification (HP:0100569)1.66963072
139Ankyloglossia (HP:0010296)1.66873314
140Cortical dysplasia (HP:0002539)1.66096828
141Type I transferrin isoform profile (HP:0003642)1.65411562
142Abnormality of oral frenula (HP:0000190)1.64592311
143Bowel diverticulosis (HP:0005222)1.64039209
144Exocrine pancreatic insufficiency (HP:0001738)1.62932149
145Spinal rigidity (HP:0003306)1.62630425
146Hepatocellular carcinoma (HP:0001402)1.62083030
147Decreased skull ossification (HP:0004331)1.61182356
148Ovoid vertebral bodies (HP:0003300)1.60834077
149Sparse eyelashes (HP:0000653)1.60755513
150Abnormality of the peritoneum (HP:0002585)1.59783991
151Unilateral renal agenesis (HP:0000122)1.58745554
152Neoplasm of the peripheral nervous system (HP:0100007)1.58604167
153Curly hair (HP:0002212)1.58309302
154Glucose intolerance (HP:0000833)1.57150958
155Fat malabsorption (HP:0002630)1.57089781
156Sparse lateral eyebrow (HP:0005338)1.56642408
157Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.55898967
158Autoamputation (HP:0001218)1.55567518
159Advanced eruption of teeth (HP:0006288)1.55456612
160Ependymoma (HP:0002888)1.54931347
161Hypokinesia (HP:0002375)1.54871023
162Neonatal short-limb short stature (HP:0008921)1.53886044
163Insidious onset (HP:0003587)1.53746780
164Termporal pattern (HP:0011008)1.53746780
165Conjugated hyperbilirubinemia (HP:0002908)1.51407811
166Abnormal gallbladder physiology (HP:0012438)1.51399061
167Cholecystitis (HP:0001082)1.51399061
168Deviation of the thumb (HP:0009603)1.50526731
169Thin skin (HP:0000963)1.50497133
170Hyperextensible skin (HP:0000974)1.50379368
171Spondylolisthesis (HP:0003302)1.49245741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.67916826
2PASK3.57143832
3FRK3.46267865
4TRIB33.23420524
5SCYL23.04751981
6MST42.89147963
7ERN12.86040634
8PKN22.85918613
9LATS12.78423596
10INSRR2.71715246
11PDGFRA2.45057312
12FLT32.31574366
13SIK12.16306396
14BUB12.12538720
15PTK62.05907925
16DDR21.87796425
17ERBB41.84604496
18TTN1.79626325
19RIPK11.77450010
20MYLK1.76657126
21SRPK11.74734013
22CDK121.71756494
23MET1.65424804
24TAOK31.63754682
25MAP3K121.61345852
26MAP3K21.59680041
27MAPK151.59138206
28EPHA31.56854139
29BRSK21.56445103
30TRIM281.54140189
31BCR1.49908427
32PNCK1.45692421
33BCKDK1.42167820
34EEF2K1.41487905
35MAP3K101.38920016
36TESK11.37921252
37PTK21.34129024
38NEK11.31660158
39NUAK11.28212028
40EIF2AK31.20826582
41FER1.19510633
42EPHA21.17525532
43MAP3K31.15873887
44NEK91.15473170
45LIMK11.13632411
46PAK41.11229084
47TGFBR11.11205462
48STK31.10247434
49MTOR1.08066656
50FGFR41.07096234
51PLK21.05265138
52DYRK1B1.03355858
53ERBB31.02011897
54CDK61.01843470
55LRRK20.98739688
56RPS6KA40.97668762
57NLK0.97150275
58PLK40.97148541
59HIPK20.95880375
60PAK30.95109741
61FGFR10.94695213
62PDGFRB0.91937221
63PRKD30.91336080
64NEK60.91176701
65PAK20.88634079
66PLK10.87861796
67MST1R0.86843854
68CDC70.81466836
69AKT30.78064280
70MKNK10.77642844
71ACVR1B0.74135903
72STK38L0.74024084
73RET0.70697257
74MKNK20.70246274
75PIK3CG0.70204778
76EIF2AK20.70202049
77MAP3K80.66640501
78CSNK1G10.65833024
79STK390.64252735
80MELK0.63693334
81STK380.63551757
82YES10.63311725
83BMX0.62916671
84RPS6KB20.62117041
85STK100.61956652
86LMTK20.61087183
87CLK10.60409066
88CHEK10.59392594
89CDC42BPA0.59233174
90PDK30.57534370
91PDK40.57534370
92FGFR30.57463208
93JAK30.56835579
94BRD40.56722949
95MAPKAPK50.55135779
96CDK70.53833638
97ATM0.53208821
98STK40.52689565
99CAMK1D0.52236763
100PRKG20.48456118
101BMPR1B0.47890570
102MAP2K10.45110337
103GSK3A0.44564886
104EIF2AK10.44519965
105NEK20.43432913
106WEE10.42974198
107TGFBR20.42757166
108PLK30.41841372
109AURKB0.41501973
110CHEK20.41292746
111NTRK10.41147098
112BRSK10.40654677
113PRKCI0.40095569
114ATR0.39109327
115ALK0.39041632
116RPS6KA20.38737355
117PRKAA10.38505135
118MAPKAPK30.38302147
119AKT20.38124487
120JAK10.37800837
121TSSK60.37510564
122TRPM70.37353500
123ROCK20.37215954
124PRKCE0.36521156
125PDK20.36504254
126RPS6KB10.35896589
127ZAP700.35594948
128PRKCH0.34931277
129IGF1R0.34661706
130CDK80.34558306
131CDK40.34038192
132TTK0.33812338
133JAK20.33659315
134LATS20.33458233
135CHUK0.33394429
136MAP2K30.33207348
137CDK30.32814143
138ILK0.32202615
139MAP4K20.32136237
140PIK3CA0.31775712
141DMPK0.31572506
142CSNK1E0.31411119
143STK160.31273518

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.39155735
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.77032181
3Protein export_Homo sapiens_hsa030603.16603272
4Selenocompound metabolism_Homo sapiens_hsa004503.01536171
5Proteasome_Homo sapiens_hsa030502.91292070
6Sulfur metabolism_Homo sapiens_hsa009202.70491957
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29015893
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25262686
9Steroid biosynthesis_Homo sapiens_hsa001001.99922062
10Non-homologous end-joining_Homo sapiens_hsa034501.95724785
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80039254
12N-Glycan biosynthesis_Homo sapiens_hsa005101.77155156
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74165339
14Fat digestion and absorption_Homo sapiens_hsa049751.63966582
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61856647
16Tryptophan metabolism_Homo sapiens_hsa003801.60311573
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56896360
18ECM-receptor interaction_Homo sapiens_hsa045121.56722775
19One carbon pool by folate_Homo sapiens_hsa006701.56385489
20Fatty acid elongation_Homo sapiens_hsa000621.50719315
21Protein digestion and absorption_Homo sapiens_hsa049741.49908493
22Starch and sucrose metabolism_Homo sapiens_hsa005001.38816939
23Fatty acid degradation_Homo sapiens_hsa000711.38101685
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36369005
25Focal adhesion_Homo sapiens_hsa045101.32940351
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29757342
27Mismatch repair_Homo sapiens_hsa034301.29218118
28Glutathione metabolism_Homo sapiens_hsa004801.28589614
29Adherens junction_Homo sapiens_hsa045201.27539905
30Lysine degradation_Homo sapiens_hsa003101.26746200
31Nucleotide excision repair_Homo sapiens_hsa034201.26137938
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24073730
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.21276106
34Insulin resistance_Homo sapiens_hsa049311.19086245
35Galactose metabolism_Homo sapiens_hsa000521.16054568
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13548404
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13070083
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12551503
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12253168
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07422753
41Bladder cancer_Homo sapiens_hsa052191.06946601
42Basal transcription factors_Homo sapiens_hsa030221.03845640
43Nitrogen metabolism_Homo sapiens_hsa009101.02816447
44Small cell lung cancer_Homo sapiens_hsa052221.00282130
45Sphingolipid metabolism_Homo sapiens_hsa006000.98862074
46Thyroid cancer_Homo sapiens_hsa052160.97176865
47Renin-angiotensin system_Homo sapiens_hsa046140.96504562
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95707604
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94913803
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.93781661
51DNA replication_Homo sapiens_hsa030300.93610071
52Prostate cancer_Homo sapiens_hsa052150.92886724
53Caffeine metabolism_Homo sapiens_hsa002320.91961580
54Vitamin B6 metabolism_Homo sapiens_hsa007500.91522903
55Antigen processing and presentation_Homo sapiens_hsa046120.91293256
56Proteoglycans in cancer_Homo sapiens_hsa052050.90928795
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.88727594
58Carbon metabolism_Homo sapiens_hsa012000.84381997
59Type II diabetes mellitus_Homo sapiens_hsa049300.84246304
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82900827
61Complement and coagulation cascades_Homo sapiens_hsa046100.82520887
62Vibrio cholerae infection_Homo sapiens_hsa051100.82464027
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82406915
64Pyruvate metabolism_Homo sapiens_hsa006200.80161675
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79770053
66mTOR signaling pathway_Homo sapiens_hsa041500.79554870
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79452938
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78954723
69Folate biosynthesis_Homo sapiens_hsa007900.78816443
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77777374
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77263998
72Biosynthesis of amino acids_Homo sapiens_hsa012300.77089528
73Glucagon signaling pathway_Homo sapiens_hsa049220.76587462
74MicroRNAs in cancer_Homo sapiens_hsa052060.76492205
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.75301481
76Spliceosome_Homo sapiens_hsa030400.75230117
77Fatty acid metabolism_Homo sapiens_hsa012120.74891818
78Lysosome_Homo sapiens_hsa041420.74638220
79TGF-beta signaling pathway_Homo sapiens_hsa043500.73992742
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.73762716
81Arginine biosynthesis_Homo sapiens_hsa002200.73304912
82Pentose phosphate pathway_Homo sapiens_hsa000300.72920478
83Propanoate metabolism_Homo sapiens_hsa006400.70354911
84Chronic myeloid leukemia_Homo sapiens_hsa052200.70096930
85Thyroid hormone synthesis_Homo sapiens_hsa049180.70056126
86Viral carcinogenesis_Homo sapiens_hsa052030.69769393
87Amoebiasis_Homo sapiens_hsa051460.69635268
88Butanoate metabolism_Homo sapiens_hsa006500.69243144
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67678302
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67336884
91Fructose and mannose metabolism_Homo sapiens_hsa000510.67134701
92Peroxisome_Homo sapiens_hsa041460.66093647
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64692880
94beta-Alanine metabolism_Homo sapiens_hsa004100.64263595
95RNA degradation_Homo sapiens_hsa030180.63789181
96RNA transport_Homo sapiens_hsa030130.63676684
97Legionellosis_Homo sapiens_hsa051340.63632768
98PPAR signaling pathway_Homo sapiens_hsa033200.62722682
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61816725
100Hippo signaling pathway_Homo sapiens_hsa043900.59339123
101AMPK signaling pathway_Homo sapiens_hsa041520.58337030
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58171541
103mRNA surveillance pathway_Homo sapiens_hsa030150.55923683
104Homologous recombination_Homo sapiens_hsa034400.55800599
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55577876
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54772941
107Pyrimidine metabolism_Homo sapiens_hsa002400.54056967
108Insulin signaling pathway_Homo sapiens_hsa049100.53943106
109Cell cycle_Homo sapiens_hsa041100.53910415
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53503427
111Fanconi anemia pathway_Homo sapiens_hsa034600.51706923
112p53 signaling pathway_Homo sapiens_hsa041150.51290238
113Endometrial cancer_Homo sapiens_hsa052130.50299850
114Bile secretion_Homo sapiens_hsa049760.50076163
115RNA polymerase_Homo sapiens_hsa030200.48547457
116Metabolic pathways_Homo sapiens_hsa011000.47756114
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46241636
118Phenylalanine metabolism_Homo sapiens_hsa003600.45170270
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44974086
120Vitamin digestion and absorption_Homo sapiens_hsa049770.44917120
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43307169
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43303304
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42924878
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42703226
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42371650
126Base excision repair_Homo sapiens_hsa034100.42293507
127Arginine and proline metabolism_Homo sapiens_hsa003300.41033772
128Pancreatic cancer_Homo sapiens_hsa052120.40533881
129Other glycan degradation_Homo sapiens_hsa005110.40504799
130Insulin secretion_Homo sapiens_hsa049110.39944039
131ABC transporters_Homo sapiens_hsa020100.39648253
132Tight junction_Homo sapiens_hsa045300.36720129
133Colorectal cancer_Homo sapiens_hsa052100.36570559
134Prolactin signaling pathway_Homo sapiens_hsa049170.36410003
135Prion diseases_Homo sapiens_hsa050200.35956605

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