COPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* COPI coating of Golgi vesicle (GO:0048205)7.92056799
2* Golgi transport vesicle coating (GO:0048200)7.92056799
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.45072129
4activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.11623754
5positive regulation of nuclease activity (GO:0032075)4.89814490
6COPII vesicle coating (GO:0048208)4.83622612
7protein retention in ER lumen (GO:0006621)4.76203361
8* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.73408340
9nuclear pore complex assembly (GO:0051292)4.69114208
10regulation of nuclease activity (GO:0032069)4.41564306
11endoplasmic reticulum unfolded protein response (GO:0030968)4.39152211
12* vesicle coating (GO:0006901)4.24627505
13cellular response to unfolded protein (GO:0034620)4.21238602
14ER-nucleus signaling pathway (GO:0006984)4.13317459
15basement membrane organization (GO:0071711)3.93914925
16cellular response to topologically incorrect protein (GO:0035967)3.92529317
17proline biosynthetic process (GO:0006561)3.91042910
18nuclear pore organization (GO:0006999)3.88706927
19insulin-like growth factor receptor signaling pathway (GO:0048009)3.59077816
20exocrine pancreas development (GO:0031017)3.57613110
21macroautophagy (GO:0016236)3.51358229
22regulation of early endosome to late endosome transport (GO:2000641)3.48093543
23response to endoplasmic reticulum stress (GO:0034976)3.46021630
24cell-substrate junction assembly (GO:0007044)3.45434766
25pore complex assembly (GO:0046931)3.45378759
26apoptotic cell clearance (GO:0043277)3.42139300
27negative regulation of fatty acid transport (GO:2000192)3.39823390
28adherens junction assembly (GO:0034333)3.32473349
29regulation of RNA export from nucleus (GO:0046831)3.30914888
30cell-substrate adherens junction assembly (GO:0007045)3.28801891
31focal adhesion assembly (GO:0048041)3.28801891
32regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.22938747
33positive regulation of histone deacetylation (GO:0031065)3.22455736
344-hydroxyproline metabolic process (GO:0019471)3.19591589
35regulation of nucleobase-containing compound transport (GO:0032239)3.18646485
36positive regulation of glycogen biosynthetic process (GO:0045725)3.14684557
37response to unfolded protein (GO:0006986)3.12378354
38hemidesmosome assembly (GO:0031581)3.11395465
39regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.04286786
40epithelial cell-cell adhesion (GO:0090136)3.03909264
41growth hormone receptor signaling pathway (GO:0060396)2.99801853
42cellular response to vitamin D (GO:0071305)2.99638403
43sequestering of metal ion (GO:0051238)2.98398255
44response to topologically incorrect protein (GO:0035966)2.95125656
45Golgi organization (GO:0007030)2.92572588
46ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.92090398
47collagen fibril organization (GO:0030199)2.91865653
48glucocorticoid receptor signaling pathway (GO:0042921)2.91073229
49regulation of fatty acid beta-oxidation (GO:0031998)2.88326184
50membrane protein ectodomain proteolysis (GO:0006509)2.87699769
51L-alpha-amino acid transmembrane transport (GO:1902475)2.87478999
52negative regulation of cell size (GO:0045792)2.87350904
53regulation of glucose import in response to insulin stimulus (GO:2001273)2.83142019
54type B pancreatic cell development (GO:0003323)2.81211205
55cellular response to vitamin (GO:0071295)2.77865242
56desmosome organization (GO:0002934)2.76295604
57embryonic process involved in female pregnancy (GO:0060136)2.75453576
58regulation of polysaccharide biosynthetic process (GO:0032885)2.74322816
59positive regulation of hormone biosynthetic process (GO:0046886)2.74081016
60barbed-end actin filament capping (GO:0051016)2.72802491
61glucose 6-phosphate metabolic process (GO:0051156)2.72443420
62peptidyl-asparagine modification (GO:0018196)2.72420630
63paraxial mesoderm development (GO:0048339)2.72362730
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.71684940
65cell adhesion mediated by integrin (GO:0033627)2.71680721
66peptidyl-lysine dimethylation (GO:0018027)2.69753337
67negative regulation of protein localization to plasma membrane (GO:1903077)2.68921816
68regulation of cholesterol homeostasis (GO:2000188)2.68917235
69protein N-linked glycosylation via asparagine (GO:0018279)2.68900391
70semaphorin-plexin signaling pathway (GO:0071526)2.68413002
71tricarboxylic acid metabolic process (GO:0072350)2.68154087
72planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67418651
73regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.66610123
74activation of Rac GTPase activity (GO:0032863)2.63894050
75protein hydroxylation (GO:0018126)2.63855715
76cellular response to growth hormone stimulus (GO:0071378)2.63677149
77protein export from nucleus (GO:0006611)2.63237759
78proline metabolic process (GO:0006560)2.62867212
79positive regulation of fatty acid beta-oxidation (GO:0032000)2.61588023
80dorsal/ventral axis specification (GO:0009950)2.60531622
81low-density lipoprotein particle clearance (GO:0034383)2.58822738
82collagen metabolic process (GO:0032963)2.58330276
83skin morphogenesis (GO:0043589)2.57901107
84midgut development (GO:0007494)2.57417000
85intra-Golgi vesicle-mediated transport (GO:0006891)2.57324222
86protein localization to endosome (GO:0036010)2.55094222
87glutamine family amino acid biosynthetic process (GO:0009084)2.54978058
88positive regulation of endothelial cell apoptotic process (GO:2000353)2.54247465
89glandular epithelial cell development (GO:0002068)2.54146965
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53730495
91positive regulation of glycogen metabolic process (GO:0070875)2.52904720
92multicellular organismal macromolecule metabolic process (GO:0044259)2.51896851
93positive regulation of p38MAPK cascade (GO:1900745)2.51204790
94peptide hormone processing (GO:0016486)2.50401566
95endocrine pancreas development (GO:0031018)2.48472469
96cytoplasmic mRNA processing body assembly (GO:0033962)2.48459164
97regulation of glucan biosynthetic process (GO:0010962)2.47776611
98regulation of glycogen biosynthetic process (GO:0005979)2.47776611
99iron ion import (GO:0097286)2.47450253
100peptidyl-proline hydroxylation (GO:0019511)2.47434379
101positive regulation of blood vessel endothelial cell migration (GO:0043536)2.47021342
102positive regulation of glycolytic process (GO:0045821)2.46140160
103retina vasculature morphogenesis in camera-type eye (GO:0061299)2.46099339
104epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45959112
105regulation of translational fidelity (GO:0006450)2.45857455
106corticosteroid receptor signaling pathway (GO:0031958)2.45583309
107cellular copper ion homeostasis (GO:0006878)2.45227228
108protein heterotrimerization (GO:0070208)2.44580342
109protein maturation by protein folding (GO:0022417)2.44386199
110negative regulation of glycogen biosynthetic process (GO:0045719)2.43824880
111collagen catabolic process (GO:0030574)2.43257977
112regulation of mitotic spindle organization (GO:0060236)2.42956819
113vascular endothelial growth factor signaling pathway (GO:0038084)2.42586975
114protein N-linked glycosylation (GO:0006487)2.42127862
115keratan sulfate catabolic process (GO:0042340)2.40964180
116endodermal cell differentiation (GO:0035987)2.40695084
117extracellular matrix disassembly (GO:0022617)2.39687930
118multicellular organismal metabolic process (GO:0044236)2.39161299
119dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.39066595
120negative regulation of anoikis (GO:2000811)2.39022974
121negative regulation of lipid transport (GO:0032369)2.38975707
122response to laminar fluid shear stress (GO:0034616)2.37438196
123hippo signaling (GO:0035329)2.36921868
124endoplasmic reticulum organization (GO:0007029)2.36669693
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.36200584
126antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.36200584
127regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36120191
128regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.35548042
129alpha-linolenic acid metabolic process (GO:0036109)2.35162994
130UDP-N-acetylglucosamine metabolic process (GO:0006047)2.35069177
131regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.34271220
132cerebellar Purkinje cell layer development (GO:0021680)2.34078299
133cortical actin cytoskeleton organization (GO:0030866)2.33920613
134cell migration involved in sprouting angiogenesis (GO:0002042)2.33568428
135positive regulation of osteoblast proliferation (GO:0033690)2.32205480
136intestinal cholesterol absorption (GO:0030299)2.31763974
137hypotonic response (GO:0006971)2.31168323
138positive regulation of nitric-oxide synthase activity (GO:0051000)2.31072637
139chondrocyte development (GO:0002063)2.30680829
140regulation of transforming growth factor beta2 production (GO:0032909)2.30676431
141positive regulation of receptor recycling (GO:0001921)2.30297103
142positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.29171638
143multicellular organismal catabolic process (GO:0044243)2.28197854
144polarized epithelial cell differentiation (GO:0030859)2.27609433
145cellular response to nutrient (GO:0031670)2.27511385
146mesodermal cell differentiation (GO:0048333)2.27422743
147plasma membrane repair (GO:0001778)2.26127722
148regulation of extracellular matrix disassembly (GO:0010715)2.26036883
149positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25990918
150ER to Golgi vesicle-mediated transport (GO:0006888)2.25860489
151ER overload response (GO:0006983)2.23413470
152positive regulation of glycoprotein metabolic process (GO:1903020)2.22744259
153stress fiber assembly (GO:0043149)2.21680402
154intestinal absorption (GO:0050892)2.21385219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.25726256
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75534458
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.68348371
4CLOCK_20551151_ChIP-Seq_293T_Human3.55458471
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.23832271
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.65942648
7E2F7_22180533_ChIP-Seq_HELA_Human2.62287169
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.53241351
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.45376014
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.34461351
11GATA1_22025678_ChIP-Seq_K562_Human2.26949060
12MYC_22102868_ChIP-Seq_BL_Human2.22498407
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14886262
14RXR_22158963_ChIP-Seq_LIVER_Mouse1.97607208
15LXR_22158963_ChIP-Seq_LIVER_Mouse1.96192940
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92527271
17PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91056007
18DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.89976406
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87252739
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86152755
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.83606093
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.80488020
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80154602
24AR_21909140_ChIP-Seq_LNCAP_Human1.79569359
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79542429
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79192617
27FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.77341618
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77074771
29KDM2B_26808549_Chip-Seq_DND41_Human1.70960005
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70887239
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70220498
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69601164
33TCF7_22412390_ChIP-Seq_EML_Mouse1.67804122
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64221619
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64209867
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62497057
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62325051
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62020691
39TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61555595
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61036817
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59000745
42* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56292773
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56184148
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.55028895
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54374822
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53936005
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.53404884
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52094489
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51507242
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50788900
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49945788
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.46726865
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45327995
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45190035
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44973529
56* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.44896709
57ATF3_27146783_Chip-Seq_COLON_Human1.44546321
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.43914141
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42512244
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40959596
61LXR_22292898_ChIP-Seq_THP-1_Human1.40357608
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40235805
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39990886
64BRD4_25478319_ChIP-Seq_HGPS_Human1.38768175
65* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.38570927
66KDM2B_26808549_Chip-Seq_K562_Human1.37544434
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36584889
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36389849
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36178880
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35983416
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35795089
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.35794256
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35745288
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34253255
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32843859
76TP53_22127205_ChIP-Seq_IMR90_Human1.31475831
77ZNF263_19887448_ChIP-Seq_K562_Human1.31370882
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.31216313
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.31216313
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29890163
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29051601
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28206512
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27985799
84RACK7_27058665_Chip-Seq_MCF-7_Human1.27582283
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27455367
86GATA6_25053715_ChIP-Seq_YYC3_Human1.26253240
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24519669
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.23378577
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23177583
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.21724356
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20497075
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20476062
93CHD1_26751641_Chip-Seq_LNCaP_Human1.20468156
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17440789
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16394094
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.16053080
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16027704
98TFEB_21752829_ChIP-Seq_HELA_Human1.15925503
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14691935
100CREB1_26743006_Chip-Seq_LNCaP_Human1.14314345
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.14050218
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13687996
103VDR_21846776_ChIP-Seq_THP-1_Human1.10668679
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.10433140
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10177213
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10124931
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09796408
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09675381
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09248618
110PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08767472
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08685570
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08464666
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08038787
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06310767
115UTX_26944678_Chip-Seq_JUKART_Human1.05803897
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05179430
117* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04083972
118NCOR1_26117541_ChIP-Seq_K562_Human1.03198066
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02450563
120SPI1_23127762_ChIP-Seq_K562_Human1.02409032
121GATA1_19941826_ChIP-Seq_K562_Human0.98938087
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98847761
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98351208
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98032147
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98032147
126CJUN_26792858_Chip-Seq_BT549_Human0.97862300
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97852348
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97318229
129MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97242919
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96444068
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95443414
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.94725549
133SOX2_20726797_ChIP-Seq_SW620_Human0.94192261
134* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94069615
135GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93550155
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.93056697
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92999368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.99233826
2MP0003705_abnormal_hypodermis_morpholog3.91604209
3MP0002877_abnormal_melanocyte_morpholog3.54072907
4MP0003300_gastrointestinal_ulcer3.05275868
5MP0006054_spinal_hemorrhage3.04245071
6MP0009780_abnormal_chondrocyte_physiolo2.89905474
7MP0010234_abnormal_vibrissa_follicle2.86890980
8MP0003283_abnormal_digestive_organ2.80861210
9MP0010352_gastrointestinal_tract_polyps2.53791323
10MP0005275_abnormal_skin_tensile2.44717454
11MP0005076_abnormal_cell_differentiation2.43821639
12MP0000013_abnormal_adipose_tissue2.42313841
13MP0002909_abnormal_adrenal_gland2.13119124
14MP0003566_abnormal_cell_adhesion2.10978675
15MP0005409_darkened_coat_color2.05635099
16MP0005171_absent_coat_pigmentation2.02780742
17MP0003183_abnormal_peptide_metabolism2.01357365
18MP0002896_abnormal_bone_mineralization1.99483515
19MP0003950_abnormal_plasma_membrane1.97794468
20MP0005503_abnormal_tendon_morphology1.95948150
21MP0000569_abnormal_digit_pigmentation1.95589177
22MP0005220_abnormal_exocrine_pancreas1.85140653
23MP0004272_abnormal_basement_membrane1.82528161
24MP0000003_abnormal_adipose_tissue1.81415651
25MP0005451_abnormal_body_composition1.81104109
26MP0003252_abnormal_bile_duct1.74259346
27MP0008961_abnormal_basal_metabolism1.73891988
28MP0001944_abnormal_pancreas_morphology1.68282532
29MP0004264_abnormal_extraembryonic_tissu1.68259118
30MP0003045_fibrosis1.56192747
31MP0005187_abnormal_penis_morphology1.49162949
32MP0005408_hypopigmentation1.48495491
33MP0003172_abnormal_lysosome_physiology1.46376133
34MP0005257_abnormal_intraocular_pressure1.40271787
35MP0001299_abnormal_eye_distance/1.40231297
36MP0002139_abnormal_hepatobiliary_system1.39412253
37MP0003941_abnormal_skin_development1.38497741
38MP0009384_cardiac_valve_regurgitation1.37617117
39MP0003091_abnormal_cell_migration1.37020795
40MP0001958_emphysema1.35981245
41MP0000537_abnormal_urethra_morphology1.33665157
42MP0003279_aneurysm1.33018050
43MP0003191_abnormal_cellular_cholesterol1.32876911
44MP0005365_abnormal_bile_salt1.31610994
45MP0002693_abnormal_pancreas_physiology1.29231345
46MP0001849_ear_inflammation1.27094416
47MP0005375_adipose_tissue_phenotype1.24987829
48MP0008260_abnormal_autophagy1.24166270
49MP0005023_abnormal_wound_healing1.23948610
50MP0003122_maternal_imprinting1.23221850
51MP0000767_abnormal_smooth_muscle1.21799574
52MP0005623_abnormal_meninges_morphology1.21665569
53MP0000733_abnormal_muscle_development1.21040120
54MP0003385_abnormal_body_wall1.17617095
55MP0001730_embryonic_growth_arrest1.15615172
56MP0003453_abnormal_keratinocyte_physiol1.13116186
57MP0005058_abnormal_lysosome_morphology1.12995565
58MP0001348_abnormal_lacrimal_gland1.11023140
59MP0005621_abnormal_cell_physiology1.10927424
60MP0004185_abnormal_adipocyte_glucose1.10783752
61MP0002234_abnormal_pharynx_morphology1.10527522
62MP0002928_abnormal_bile_duct1.09141613
63MP0003195_calcinosis1.09111816
64MP0001666_abnormal_nutrient_absorption1.08853875
65MP0010307_abnormal_tumor_latency1.05780896
66MP0001661_extended_life_span1.05295257
67MP0004233_abnormal_muscle_weight1.02676440
68MP0002086_abnormal_extraembryonic_tissu1.01335760
69MP0002295_abnormal_pulmonary_circulatio1.00509113
70MP0002078_abnormal_glucose_homeostasis1.00093064
71MP0004130_abnormal_muscle_cell1.00030314
72MP0002060_abnormal_skin_morphology0.98753017
73MP0000428_abnormal_craniofacial_morphol0.97993723
74MP0002168_other_aberrant_phenotype0.97958239
75MP0002089_abnormal_postnatal_growth/wei0.97713196
76MP0003303_peritoneal_inflammation0.95421880
77MP0003329_amyloid_beta_deposits0.95368881
78MP0010368_abnormal_lymphatic_system0.93580958
79MP0000751_myopathy0.93216602
80MP0004197_abnormal_fetal_growth/weight/0.92812203
81MP0000747_muscle_weakness0.92470075
82MP0005666_abnormal_adipose_tissue0.91438304
83MP0005360_urolithiasis0.90575489
84MP0005508_abnormal_skeleton_morphology0.90056819
85MP0006138_congestive_heart_failure0.90028738
86MP0003984_embryonic_growth_retardation0.89501965
87MP0010386_abnormal_urinary_bladder0.88818981
88MP0003795_abnormal_bone_structure0.88190987
89MP0004043_abnormal_pH_regulation0.87852242
90MP0000163_abnormal_cartilage_morphology0.86649182
91MP0009053_abnormal_anal_canal0.86239854
92MP0002166_altered_tumor_susceptibility0.85994068
93MP0003115_abnormal_respiratory_system0.85882813
94MP0000534_abnormal_ureter_morphology0.85782439
95MP0002084_abnormal_developmental_patter0.84897189
96MP0010030_abnormal_orbit_morphology0.83697976
97MP0005380_embryogenesis_phenotype0.83676073
98MP0001672_abnormal_embryogenesis/_devel0.83676073
99MP0005501_abnormal_skin_physiology0.83362801
100MP0005197_abnormal_uvea_morphology0.83251136
101MP0003634_abnormal_glial_cell0.83235816
102MP0002088_abnormal_embryonic_growth/wei0.82966998
103MP0003868_abnormal_feces_composition0.82845058
104MP0002080_prenatal_lethality0.81479384
105MP0005384_cellular_phenotype0.81021653
106MP0010329_abnormal_lipoprotein_level0.80824734
107MP0002115_abnormal_skeleton_extremities0.80708442
108MP0004858_abnormal_nervous_system0.79871872
109MP0000462_abnormal_digestive_system0.79829036
110MP0001270_distended_abdomen0.79459835
111MP0009672_abnormal_birth_weight0.78777096
112MP0001756_abnormal_urination0.78764300
113MP0000858_altered_metastatic_potential0.78605809
114MP0002998_abnormal_bone_remodeling0.78464399
115MP0009703_decreased_birth_body0.78440678
116MP0000759_abnormal_skeletal_muscle0.78319041
117MP0009643_abnormal_urine_homeostasis0.77735633
118MP0004947_skin_inflammation0.76705546
119MP0005248_abnormal_Harderian_gland0.76133624
120MP0004782_abnormal_surfactant_physiolog0.76123750
121MP0001186_pigmentation_phenotype0.75912942
122MP0000377_abnormal_hair_follicle0.75598304
123MP0003959_abnormal_lean_body0.75373076
124MP0002269_muscular_atrophy0.75125373
125MP0000350_abnormal_cell_proliferation0.75108953
126MP0000371_diluted_coat_color0.74658089
127MP0001614_abnormal_blood_vessel0.74540683
128MP0008932_abnormal_embryonic_tissue0.73971749
129MP0001915_intracranial_hemorrhage0.73920049
130MP0003942_abnormal_urinary_system0.73337902
131MP0010630_abnormal_cardiac_muscle0.72984133
132MP0002075_abnormal_coat/hair_pigmentati0.72953078
133MP0002113_abnormal_skeleton_development0.71586274
134MP0000609_abnormal_liver_physiology0.70773459
135MP0002796_impaired_skin_barrier0.70628782
136MP0000762_abnormal_tongue_morphology0.70122089
137MP0003935_abnormal_craniofacial_develop0.70090168
138MP0001533_abnormal_skeleton_physiology0.69841799
139MP0000467_abnormal_esophagus_morphology0.69528129
140MP0004084_abnormal_cardiac_muscle0.69456549
141MP0001243_abnormal_dermal_layer0.69449829
142MP0002108_abnormal_muscle_morphology0.67581805
143MP0002837_dystrophic_cardiac_calcinosis0.66852446
144MP0009840_abnormal_foam_cell0.66372881
145MP0003123_paternal_imprinting0.66283857
146MP0005083_abnormal_biliary_tract0.66259845
147MP0002925_abnormal_cardiovascular_devel0.65753444
148MP0004087_abnormal_muscle_fiber0.65709569
149MP0000432_abnormal_head_morphology0.64971997

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.82343308
2Cerebral aneurysm (HP:0004944)3.77717018
3Cervical subluxation (HP:0003308)3.13581934
4Premature rupture of membranes (HP:0001788)3.09426572
5Vertebral compression fractures (HP:0002953)3.06714661
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.99077724
7Aortic aneurysm (HP:0004942)2.96741737
8Shallow orbits (HP:0000586)2.90726506
9Hand muscle atrophy (HP:0009130)2.80706276
10Abnormality of dentin (HP:0010299)2.80657578
11Ankle contracture (HP:0006466)2.77251427
12Aneurysm (HP:0002617)2.67741352
13Macroorchidism (HP:0000053)2.65391803
14Hypoglycemic seizures (HP:0002173)2.62576215
15Hyperinsulinemic hypoglycemia (HP:0000825)2.61561354
16Subacute progressive viral hepatitis (HP:0006572)2.60438582
17Fragile skin (HP:0001030)2.58790111
18Long toe (HP:0010511)2.57466642
19Dilatation of the ascending aorta (HP:0005111)2.56952013
20Aortic dissection (HP:0002647)2.56642071
21Osteolytic defects of the hand bones (HP:0009699)2.55249956
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.55249956
23Bladder diverticulum (HP:0000015)2.51981705
24Mitral valve prolapse (HP:0001634)2.51494103
25Upper limb amyotrophy (HP:0009129)2.47814692
26Distal upper limb amyotrophy (HP:0007149)2.47814692
27Short nail (HP:0001799)2.47344445
28Hypoglycemic coma (HP:0001325)2.43914067
29Spinal rigidity (HP:0003306)2.42180621
30Bowel diverticulosis (HP:0005222)2.40237525
31Urinary glycosaminoglycan excretion (HP:0003541)2.39830987
32Mucopolysacchariduria (HP:0008155)2.39830987
33Asymmetry of the thorax (HP:0001555)2.38078271
34Insomnia (HP:0100785)2.34121855
35Hyperglycemia (HP:0003074)2.31031115
36Lymphangioma (HP:0100764)2.28303210
37Hyperacusis (HP:0010780)2.27562908
38Thin bony cortex (HP:0002753)2.27337295
39Increased connective tissue (HP:0009025)2.26552709
40Disproportionate tall stature (HP:0001519)2.24639414
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24043802
42Abnormality of polysaccharide metabolism (HP:0011012)2.24043802
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24043802
44Abnormal gallbladder physiology (HP:0012438)2.20194970
45Cholecystitis (HP:0001082)2.20194970
46Distal lower limb amyotrophy (HP:0008944)2.20090444
47Abnormality of endocrine pancreas physiology (HP:0012093)2.18969421
48Abnormality of the pancreatic islet cells (HP:0006476)2.18969421
49Hammertoe (HP:0001765)2.18552115
50Atrophic scars (HP:0001075)2.18375879
51Thoracolumbar scoliosis (HP:0002944)2.17081607
52Follicular hyperkeratosis (HP:0007502)2.14383184
53Striae distensae (HP:0001065)2.14174330
54Severe short stature (HP:0003510)2.13867255
55Exostoses (HP:0100777)2.12866506
56Termporal pattern (HP:0011008)2.11202524
57Insidious onset (HP:0003587)2.11202524
58Neonatal short-limb short stature (HP:0008921)2.10723911
59Mitral regurgitation (HP:0001653)2.08997052
60Broad metatarsal (HP:0001783)2.07477007
61Achilles tendon contracture (HP:0001771)2.06666993
62Dysostosis multiplex (HP:0000943)2.06553386
63Joint laxity (HP:0001388)2.06428301
64Enlarged penis (HP:0000040)2.06081791
65Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05674669
66Elbow flexion contracture (HP:0002987)2.05082968
67Natal tooth (HP:0000695)2.01648717
68Abnormal delivery (HP:0001787)2.00136489
69Peritonitis (HP:0002586)1.99760371
70Genu recurvatum (HP:0002816)1.99230069
71Symptomatic seizures (HP:0011145)1.98188044
72Abnormality of the Achilles tendon (HP:0005109)1.97577784
73Sparse lateral eyebrow (HP:0005338)1.94998070
74Back pain (HP:0003418)1.94364158
75Cortical dysplasia (HP:0002539)1.93073461
76Long palpebral fissure (HP:0000637)1.92091798
77Biconcave vertebral bodies (HP:0004586)1.91184214
78Mildly elevated creatine phosphokinase (HP:0008180)1.90516602
79Insulin-resistant diabetes mellitus (HP:0000831)1.90333901
80Ketoacidosis (HP:0001993)1.90150915
81Spondylolisthesis (HP:0003302)1.88161200
82Premature skin wrinkling (HP:0100678)1.88024117
83Upper limb muscle weakness (HP:0003484)1.87573576
84Abnormality of the intrinsic pathway (HP:0010989)1.86531515
85Metaphyseal cupping (HP:0003021)1.85926148
86Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84496281
87Short 4th metacarpal (HP:0010044)1.84496281
88Ulnar bowing (HP:0003031)1.83167362
89Wormian bones (HP:0002645)1.82746293
90Radial bowing (HP:0002986)1.82434948
91Hypoplastic ischia (HP:0003175)1.80970083
92Turricephaly (HP:0000262)1.80710595
93Mitral stenosis (HP:0001718)1.80523983
94Renovascular hypertension (HP:0100817)1.80025610
95Relative macrocephaly (HP:0004482)1.79223091
96Flat cornea (HP:0007720)1.78030121
97Deviation of the hallux (HP:0010051)1.77569420
98Blue sclerae (HP:0000592)1.77431385
99Renal duplication (HP:0000075)1.76815965
100Hallux valgus (HP:0001822)1.76721978
101Increased variability in muscle fiber diameter (HP:0003557)1.76593675
102Flat acetabular roof (HP:0003180)1.75093213
103Elfin facies (HP:0004428)1.75090736
104Pancreatic islet-cell hyperplasia (HP:0004510)1.75085966
105Overlapping toe (HP:0001845)1.74927899
106Advanced eruption of teeth (HP:0006288)1.74736955
107Abnormality of the common coagulation pathway (HP:0010990)1.74528942
108Congenital glaucoma (HP:0001087)1.73746680
109Abnormality of the distal phalanges of the toes (HP:0010182)1.73527966
110Breech presentation (HP:0001623)1.72845640
111Vertebral arch anomaly (HP:0008438)1.72843158
112Lower limb amyotrophy (HP:0007210)1.72186074
113Overgrowth (HP:0001548)1.71493127
114Neoplasm of the heart (HP:0100544)1.70798222
115Abnormality of carpal bone ossification (HP:0006257)1.70358787
116Abnormal ossification of hand bones (HP:0005921)1.69959889
117Increased density of long bones (HP:0006392)1.68127885
118Tibial bowing (HP:0002982)1.67896864
119Hypercortisolism (HP:0001578)1.67780718
120Skin nodule (HP:0200036)1.67737873
121Late onset (HP:0003584)1.67572943
122Protruding ear (HP:0000411)1.67157956
123Wide anterior fontanel (HP:0000260)1.67103690
124Abnormality of oral frenula (HP:0000190)1.66321402
125Impaired pain sensation (HP:0007328)1.65718258
126Abnormality of pain sensation (HP:0010832)1.65718258
127Deep philtrum (HP:0002002)1.65233242
128Right ventricular cardiomyopathy (HP:0011663)1.65025522
129Abnormality of the ischium (HP:0003174)1.64521198
130Hepatoblastoma (HP:0002884)1.64201855
131Deep venous thrombosis (HP:0002625)1.63848177
132Protuberant abdomen (HP:0001538)1.63216025
133Syringomyelia (HP:0003396)1.61839412
134Spinal cord lesions (HP:0100561)1.61839412
135Buphthalmos (HP:0000557)1.61815519
136Ectopia lentis (HP:0001083)1.60948017
137Rectal prolapse (HP:0002035)1.60888077
138Abdominal distention (HP:0003270)1.60530176
139Nonimmune hydrops fetalis (HP:0001790)1.60452590
140Platyspondyly (HP:0000926)1.60041857
141Cardiovascular calcification (HP:0011915)1.59656144
142Abnormality of skeletal muscle fiber size (HP:0012084)1.59378205
143Vascular tortuosity (HP:0004948)1.59359341
144Abnormal foot bone ossification (HP:0010675)1.59328305
145Abnormality of the 4th metacarpal (HP:0010012)1.59324004
146Abnormality of the calcaneus (HP:0008364)1.58128633
147Patellar dislocation (HP:0002999)1.57989435
148Hematochezia (HP:0002573)1.57696690
149Abnormal pancreas size (HP:0012094)1.57644151
150Abnormality of the acetabulum (HP:0003170)1.57591184
151Inguinal hernia (HP:0000023)1.57491142
152Micronodular cirrhosis (HP:0001413)1.57341708
153Scapular winging (HP:0003691)1.57002611
154Arterial tortuosity (HP:0005116)1.56717930
155Soft skin (HP:0000977)1.55656919
156Insulin resistance (HP:0000855)1.54295280
157Ankyloglossia (HP:0010296)1.52361325
158Broad face (HP:0000283)1.52212770
159Hyperextensible skin (HP:0000974)1.52160713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.44634719
2ERN13.42435710
3PKN23.31554490
4EEF2K3.05175134
5PDGFRA3.02599168
6SIK12.67266778
7RIPK12.47820110
8PASK2.47431264
9SCYL22.39407148
10PTK62.36339395
11MAP3K102.30938697
12TTN2.18385951
13LATS12.14562596
14FRK2.11604516
15FLT31.90353551
16DDR21.89820508
17EPHA21.89519975
18PRPF4B1.86322659
19FGFR41.78159155
20IRAK31.77348043
21INSRR1.76253143
22TAOK31.68040270
23CDK121.59178782
24EPHA31.56074321
25CAMK1D1.50105395
26PTK21.48509889
27SMG11.46368874
28MAP3K21.38468341
29PRKD31.35272378
30CAMK1G1.29396632
31FGFR31.28721400
32PDGFRB1.28091208
33EIF2AK11.26230178
34RET1.25867111
35MTOR1.19494943
36LRRK21.18131193
37PDK21.15577521
38MET1.14868510
39FGFR21.14388284
40FER1.11901993
41MAP3K61.05064727
42JAK11.04699503
43PRKCH1.01346933
44CAMKK10.99655620
45HIPK20.98436004
46PAK20.98373913
47BMX0.95347376
48FGFR10.94013879
49NTRK10.93773512
50TESK10.93526327
51PBK0.91207918
52STK380.89632340
53TTK0.89288775
54PAK30.88460112
55ERBB40.87684244
56MAPKAPK30.84990540
57PAK40.84557366
58CLK10.84517677
59MST1R0.81972478
60DYRK1B0.80461398
61JAK30.73710998
62MAP3K80.73330341
63CDC42BPA0.72942014
64CDK60.71751768
65EPHB10.71545965
66SIK30.70983811
67ALK0.70922075
68MAP3K130.68736331
69MYLK0.68634360
70STK30.68617519
71RPS6KA20.68241978
72ICK0.67627542
73PDPK10.67089707
74STK38L0.65677820
75TYRO30.64588212
76NEK60.63244342
77JAK20.62549625
78ITK0.61760753
79STK100.61453692
80KSR20.60763329
81NEK90.58683675
82DMPK0.58242873
83TGFBR10.58112930
84AKT30.57532164
85MAP3K30.56361435
86TGFBR20.55660439
87LIMK10.55568440
88MARK20.55268579
89BRD40.54782097
90RAF10.54039205
91LMTK20.53727084
92SGK30.53607098
93ZAP700.53566173
94ERBB20.53493797
95ERBB30.52955164
96TSSK60.52471045
97PRKD20.52270715
98MAPK150.50644091
99AKT20.50318357
100MAP3K10.48864040
101MOS0.48520549
102PIK3CG0.47996972
103TAOK10.45869298
104CAMKK20.45253583
105MAP3K70.44949124
106YES10.44888521
107WNK10.43561886
108PRKG20.43376511
109KSR10.42904050
110PRKD10.41348984
111MAP2K10.40937119
112ROCK20.40817676
113RPS6KA40.40346375
114CDK70.40290787
115RPS6KB20.39800203
116ARAF0.39785470
117PRKAA10.39359915
118CDK150.39210669
119CDK180.38985112
120MAP3K90.38314766
121NEK10.38212844
122TRPM70.37914025
123BCR0.37845146
124GSK3A0.37684246
125ILK0.37218662
126EGFR0.36974332
127ROCK10.36191905
128CHEK10.35570336
129CDK11A0.35188154
130PAK60.33770604
131CHUK0.33713694
132MAP3K140.32130805
133EIF2AK30.31443915
134CSK0.31411597
135CDK140.31106715
136IGF1R0.30925778
137CDK90.30213720
138EPHB20.30076530
139LATS20.29858522
140SRC0.29475998
141MAPK110.28567908
142INSR0.28365067

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.37679835
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.67518205
3Other glycan degradation_Homo sapiens_hsa005112.06634211
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00590636
5Type II diabetes mellitus_Homo sapiens_hsa049301.80266964
6Biosynthesis of amino acids_Homo sapiens_hsa012301.69936269
7Nitrogen metabolism_Homo sapiens_hsa009101.57287237
8Insulin resistance_Homo sapiens_hsa049311.53614744
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52438485
10Focal adhesion_Homo sapiens_hsa045101.51416113
11N-Glycan biosynthesis_Homo sapiens_hsa005101.48171677
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46644831
13Chronic myeloid leukemia_Homo sapiens_hsa052201.46589047
14Pentose phosphate pathway_Homo sapiens_hsa000301.45952050
15mTOR signaling pathway_Homo sapiens_hsa041501.45472330
16Protein digestion and absorption_Homo sapiens_hsa049741.40912004
17ECM-receptor interaction_Homo sapiens_hsa045121.39811238
18Lysine degradation_Homo sapiens_hsa003101.34046078
19Selenocompound metabolism_Homo sapiens_hsa004501.33958475
20Adherens junction_Homo sapiens_hsa045201.32214945
21Fructose and mannose metabolism_Homo sapiens_hsa000511.29469454
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28141915
23Proteoglycans in cancer_Homo sapiens_hsa052051.25926657
24Insulin secretion_Homo sapiens_hsa049111.20810864
25Lysosome_Homo sapiens_hsa041421.18722898
26Endometrial cancer_Homo sapiens_hsa052131.18475143
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.16996121
28Carbon metabolism_Homo sapiens_hsa012001.16356770
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.15494967
30Sulfur metabolism_Homo sapiens_hsa009201.09746809
31Amoebiasis_Homo sapiens_hsa051461.08156988
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07113445
33Pancreatic cancer_Homo sapiens_hsa052121.07019981
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05681135
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.05613087
36Bladder cancer_Homo sapiens_hsa052191.05273073
37Glioma_Homo sapiens_hsa052141.02804684
38Thyroid hormone synthesis_Homo sapiens_hsa049181.01435950
39Small cell lung cancer_Homo sapiens_hsa052221.00037012
40ErbB signaling pathway_Homo sapiens_hsa040120.99860206
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98460154
42Insulin signaling pathway_Homo sapiens_hsa049100.98453592
43Sphingolipid metabolism_Homo sapiens_hsa006000.98190627
44Glucagon signaling pathway_Homo sapiens_hsa049220.97880844
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96641838
46Estrogen signaling pathway_Homo sapiens_hsa049150.96132263
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.95848263
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95227521
49Prolactin signaling pathway_Homo sapiens_hsa049170.95185512
50AMPK signaling pathway_Homo sapiens_hsa041520.93448210
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92689526
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89314185
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87527974
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87057781
55Fat digestion and absorption_Homo sapiens_hsa049750.87056437
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85800099
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85035410
58MicroRNAs in cancer_Homo sapiens_hsa052060.84148350
59Inositol phosphate metabolism_Homo sapiens_hsa005620.83521478
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83382475
61Non-small cell lung cancer_Homo sapiens_hsa052230.83366992
62Renin-angiotensin system_Homo sapiens_hsa046140.82236324
63Bile secretion_Homo sapiens_hsa049760.82068874
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81784674
65Shigellosis_Homo sapiens_hsa051310.81704127
66Colorectal cancer_Homo sapiens_hsa052100.81464283
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81324998
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.80793021
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79858405
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.79355650
71Toxoplasmosis_Homo sapiens_hsa051450.78886809
72Starch and sucrose metabolism_Homo sapiens_hsa005000.76947268
73Prostate cancer_Homo sapiens_hsa052150.76150064
74Vibrio cholerae infection_Homo sapiens_hsa051100.75333205
75Complement and coagulation cascades_Homo sapiens_hsa046100.75100265
76Tryptophan metabolism_Homo sapiens_hsa003800.74658035
77HIF-1 signaling pathway_Homo sapiens_hsa040660.74455326
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74039454
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73128442
80Antigen processing and presentation_Homo sapiens_hsa046120.72747623
81Fatty acid degradation_Homo sapiens_hsa000710.72436326
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72298168
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71996804
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.69562963
85Prion diseases_Homo sapiens_hsa050200.69207186
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68792462
87Renal cell carcinoma_Homo sapiens_hsa052110.68554501
88Caffeine metabolism_Homo sapiens_hsa002320.68332067
89Tight junction_Homo sapiens_hsa045300.68050816
90Choline metabolism in cancer_Homo sapiens_hsa052310.67929795
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66930942
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66534960
93Dorso-ventral axis formation_Homo sapiens_hsa043200.65826971
94Platelet activation_Homo sapiens_hsa046110.65094391
95VEGF signaling pathway_Homo sapiens_hsa043700.64429497
96Viral myocarditis_Homo sapiens_hsa054160.64209182
97Hippo signaling pathway_Homo sapiens_hsa043900.63965975
98Pancreatic secretion_Homo sapiens_hsa049720.63421689
99Arginine biosynthesis_Homo sapiens_hsa002200.62994140
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62256718
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62201686
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61280793
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61055523
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60812116
105Gap junction_Homo sapiens_hsa045400.60800981
106Notch signaling pathway_Homo sapiens_hsa043300.60162727
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.60084763
108Pathways in cancer_Homo sapiens_hsa052000.59704900
109Galactose metabolism_Homo sapiens_hsa000520.59069672
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57863071
111Dilated cardiomyopathy_Homo sapiens_hsa054140.57689681
112Fatty acid metabolism_Homo sapiens_hsa012120.55639215
113Vitamin B6 metabolism_Homo sapiens_hsa007500.55443511
114FoxO signaling pathway_Homo sapiens_hsa040680.55172844
115Endocytosis_Homo sapiens_hsa041440.55083573
116GnRH signaling pathway_Homo sapiens_hsa049120.54563767
117Viral carcinogenesis_Homo sapiens_hsa052030.54524287
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54217929
119Axon guidance_Homo sapiens_hsa043600.53944007
120Thyroid cancer_Homo sapiens_hsa052160.53943349
121Melanoma_Homo sapiens_hsa052180.53715375
122Legionellosis_Homo sapiens_hsa051340.53516957
123PPAR signaling pathway_Homo sapiens_hsa033200.51542583
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51030072
125Osteoclast differentiation_Homo sapiens_hsa043800.49838239
126Acute myeloid leukemia_Homo sapiens_hsa052210.49402845
127Steroid biosynthesis_Homo sapiens_hsa001000.48667123
128Protein export_Homo sapiens_hsa030600.48553282
129Hepatitis B_Homo sapiens_hsa051610.48217013
130ABC transporters_Homo sapiens_hsa020100.47757441
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47584816
132Hepatitis C_Homo sapiens_hsa051600.47468469
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46487442
134TNF signaling pathway_Homo sapiens_hsa046680.46471089
135Melanogenesis_Homo sapiens_hsa049160.45966786
136Apoptosis_Homo sapiens_hsa042100.45329725

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