COMMD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.25146443
2central nervous system myelination (GO:0022010)7.25146443
3neuron cell-cell adhesion (GO:0007158)5.10551220
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.00315888
5fatty acid elongation (GO:0030497)4.97013804
6autophagic vacuole fusion (GO:0000046)4.93720741
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.91948846
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.90770654
9long-chain fatty acid biosynthetic process (GO:0042759)4.81058869
10ATP synthesis coupled proton transport (GO:0015986)4.80168557
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.80168557
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.74561456
13purine deoxyribonucleotide catabolic process (GO:0009155)4.65274937
14deoxyribonucleotide catabolic process (GO:0009264)4.63041615
15negative regulation of calcium ion transport into cytosol (GO:0010523)4.54904794
16myelination (GO:0042552)4.48381444
17ensheathment of neurons (GO:0007272)4.42444810
18axon ensheathment (GO:0008366)4.42444810
19deoxyribose phosphate catabolic process (GO:0046386)4.34345056
20neutrophil activation involved in immune response (GO:0002283)4.29015454
21presynaptic membrane assembly (GO:0097105)4.25915269
22presynaptic membrane organization (GO:0097090)4.17300722
23negative regulation of neurotransmitter transport (GO:0051589)4.09572261
24Arp2/3 complex-mediated actin nucleation (GO:0034314)4.01946476
25respiratory electron transport chain (GO:0022904)3.97425306
26positive regulation of B cell differentiation (GO:0045579)3.96715271
27pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.93988470
28pyrimidine nucleotide catabolic process (GO:0006244)3.93729986
29purine nucleotide salvage (GO:0032261)3.92032636
30nucleotide salvage (GO:0043173)3.90627679
31electron transport chain (GO:0022900)3.87181972
32glycerophospholipid catabolic process (GO:0046475)3.85741719
33cholesterol biosynthetic process (GO:0006695)3.85388220
34substantia nigra development (GO:0021762)3.80951836
35dopamine biosynthetic process (GO:0042416)3.78085033
36transmission of nerve impulse (GO:0019226)3.72668016
37protein neddylation (GO:0045116)3.71302831
38negative regulation of protein localization to cell surface (GO:2000009)3.69091732
39neuronal action potential propagation (GO:0019227)3.68780390
40organelle membrane fusion (GO:0090174)3.63359510
41protein maturation by protein folding (GO:0022417)3.56245170
42regulation of dopamine metabolic process (GO:0042053)3.53931854
43regulation of catecholamine metabolic process (GO:0042069)3.53931854
44regulation of collateral sprouting (GO:0048670)3.53624608
452-deoxyribonucleotide metabolic process (GO:0009394)3.51935986
46neuron remodeling (GO:0016322)3.48425611
47response to redox state (GO:0051775)3.47515125
48neuron recognition (GO:0008038)3.47169160
49cellular response to epinephrine stimulus (GO:0071872)3.44668977
50immunoglobulin mediated immune response (GO:0016064)3.42831489
51base-excision repair, AP site formation (GO:0006285)3.42473217
52chaperone-mediated protein transport (GO:0072321)3.40252688
53sterol biosynthetic process (GO:0016126)3.38577091
54deoxyribose phosphate metabolic process (GO:0019692)3.37894631
55iron-sulfur cluster assembly (GO:0016226)3.36857237
56metallo-sulfur cluster assembly (GO:0031163)3.36857237
57L-amino acid import (GO:0043092)3.33959914
58regulation of response to osmotic stress (GO:0047484)3.29142289
59negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.27979662
60oligodendrocyte differentiation (GO:0048709)3.23826691
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.21780148
62isoprenoid biosynthetic process (GO:0008299)3.19290199
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.17878722
64purine deoxyribonucleotide metabolic process (GO:0009151)3.17768342
65negative regulation of neurotransmitter secretion (GO:0046929)3.17443102
66response to epinephrine (GO:0071871)3.17397590
67actin nucleation (GO:0045010)3.14929829
68DNA deamination (GO:0045006)3.09878129
69response to methylmercury (GO:0051597)3.08043861
70pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.06588299
71regulation of neuron projection regeneration (GO:0070570)3.05793884
72regulation of axon regeneration (GO:0048679)3.05793884
73regulation of glutamate secretion (GO:0014048)3.04412282
742-deoxyribonucleotide biosynthetic process (GO:0009265)3.04282820
75deoxyribose phosphate biosynthetic process (GO:0046385)3.04282820
76mitochondrial calcium ion transport (GO:0006851)3.03541890
77mature B cell differentiation involved in immune response (GO:0002313)3.02230835
78dopamine transport (GO:0015872)3.02156919
79negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.02065673
80positive regulation of synapse assembly (GO:0051965)3.02043188
81negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.01073162
82lipoxygenase pathway (GO:0019372)3.01031879
83thrombin receptor signaling pathway (GO:0070493)3.00520021
84glutamate receptor signaling pathway (GO:0007215)3.00475599
85activated T cell proliferation (GO:0050798)2.99710394
86negative regulation of axon extension (GO:0030517)2.99691625
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.98799550
88synaptic transmission, dopaminergic (GO:0001963)2.98525503
89deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95544915
90chaperone mediated protein folding requiring cofactor (GO:0051085)2.94660289
91pinocytosis (GO:0006907)2.93977489
92response to interferon-beta (GO:0035456)2.91329253
93protein localization to synapse (GO:0035418)2.89473815
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88743588
95neurotransmitter uptake (GO:0001504)2.88596918
96purine-containing compound salvage (GO:0043101)2.88137394
97deoxyribonucleotide metabolic process (GO:0009262)2.87445950
98cyclooxygenase pathway (GO:0019371)2.86730244
99negative regulation of B cell apoptotic process (GO:0002903)2.84456299
100pyrimidine-containing compound salvage (GO:0008655)2.84119782
101pyrimidine nucleoside salvage (GO:0043097)2.84119782
102B cell mediated immunity (GO:0019724)2.82060458
103axonal fasciculation (GO:0007413)2.80693840
104nucleoside salvage (GO:0043174)2.78996443
105amino acid import (GO:0043090)2.77314636
106behavioral response to cocaine (GO:0048148)2.76248619
107hydrogen ion transmembrane transport (GO:1902600)2.76185186
108regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76088728
109positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.75611768
110regulation of mast cell degranulation (GO:0043304)2.74928654
111mating behavior (GO:0007617)2.73781672
112negative regulation of cation channel activity (GO:2001258)2.69990151
113purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.68194402
114calcium-mediated signaling using intracellular calcium source (GO:0035584)2.68142272
115endothelium development (GO:0003158)2.68023672
116protein complex biogenesis (GO:0070271)2.68003142
117limb bud formation (GO:0060174)2.67486843
118positive regulation of protein homodimerization activity (GO:0090073)2.66951291
119negative regulation of nitric oxide biosynthetic process (GO:0045019)2.65852755
120negative regulation of thymocyte apoptotic process (GO:0070244)2.65547367
121energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.65040257
122ATP hydrolysis coupled proton transport (GO:0015991)2.65040257
123negative regulation of axonogenesis (GO:0050771)2.64718498
124positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.63777569
125positive regulation of action potential (GO:0045760)2.63485543
126neuron-neuron synaptic transmission (GO:0007270)2.63409766
127dendritic spine morphogenesis (GO:0060997)2.62718096
128negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61540346
129oxidative phosphorylation (GO:0006119)2.60236131
130angiogenesis involved in wound healing (GO:0060055)2.60030858
131neural nucleus development (GO:0048857)2.59917944
132negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59851969
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59325618
134purinergic nucleotide receptor signaling pathway (GO:0035590)2.58180385
135adult walking behavior (GO:0007628)2.58177609
136proton transport (GO:0015992)2.58059105
137regulation of vesicle fusion (GO:0031338)2.57800164
138aggressive behavior (GO:0002118)2.56661404
139Peyers patch development (GO:0048541)2.56414416
140mucosal-associated lymphoid tissue development (GO:0048537)2.56414416
141establishment of mitochondrion localization (GO:0051654)2.56026465
142synaptic vesicle exocytosis (GO:0016079)2.54941676
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.54075398
144platelet aggregation (GO:0070527)2.53941566
145prostaglandin biosynthetic process (GO:0001516)2.53116527
146prostanoid biosynthetic process (GO:0046457)2.53116527
147neuronal ion channel clustering (GO:0045161)2.52284321
148vocalization behavior (GO:0071625)2.52198664
149hydrogen transport (GO:0006818)2.51855373
150photoreceptor cell differentiation (GO:0046530)2.51676301
151eye photoreceptor cell differentiation (GO:0001754)2.51676301
152regulation of mitochondrial translation (GO:0070129)2.51344477
153regulation of feeding behavior (GO:0060259)2.50615806
154astrocyte development (GO:0014002)2.50612755
155pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.50349878
156pentose metabolic process (GO:0019321)2.49174255
157positive regulation of antigen processing and presentation (GO:0002579)2.48699524
158tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48410402
159RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48410402
160neutrophil activation (GO:0042119)2.48318193
161sequestering of actin monomers (GO:0042989)2.46572114
162response to cocaine (GO:0042220)2.46162530
163regulation of mast cell activation involved in immune response (GO:0033006)2.45839395
164mitochondrial calcium ion homeostasis (GO:0051560)2.45556873
165synaptic transmission, glutamatergic (GO:0035249)2.44276312
166cellular response to interferon-beta (GO:0035458)2.44019536
167neurotransmitter catabolic process (GO:0042135)2.43474356
168regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43275491
169positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42984604
170mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.42982015
171GMP metabolic process (GO:0046037)2.42879368
172negative regulation of T cell apoptotic process (GO:0070233)2.42710947
173postsynaptic membrane organization (GO:0001941)2.42366861
174membrane assembly (GO:0071709)2.42052526
175cellular metabolic compound salvage (GO:0043094)2.40954694
176mitochondrial respiratory chain complex assembly (GO:0033108)2.40786514
177catecholamine biosynthetic process (GO:0042423)2.40306045
178catechol-containing compound biosynthetic process (GO:0009713)2.40306045
179cellular response to monoamine stimulus (GO:0071868)2.40128912
180cellular response to catecholamine stimulus (GO:0071870)2.40128912
181negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.39794288
182regulation of T-helper 1 cell differentiation (GO:0045625)2.39294284
183regulation of B cell apoptotic process (GO:0002902)2.38022319
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.37802460
185purinergic receptor signaling pathway (GO:0035587)2.36961738
186regulation of cellular amino acid metabolic process (GO:0006521)2.36488031
187antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.35634601
188regulation of antigen processing and presentation (GO:0002577)2.35506390
189regulation of B cell differentiation (GO:0045577)2.34835764
190response to peptidoglycan (GO:0032494)2.33923642
191positive regulation of mast cell activation involved in immune response (GO:0033008)2.32712469
192positive regulation of mast cell degranulation (GO:0043306)2.32712469
193negative regulation of lymphocyte apoptotic process (GO:0070229)2.32588554
194positive regulation of lamellipodium assembly (GO:0010592)2.32357990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12431207
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77928476
3GBX2_23144817_ChIP-Seq_PC3_Human3.59723820
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.56133851
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.38624419
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.27986053
7TAF15_26573619_Chip-Seq_HEK293_Human3.12567137
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03087509
9* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.96252109
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90059564
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79146033
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73787336
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71482826
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64672206
15* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.51348684
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51345584
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.35560507
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34065808
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31480354
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28310153
21SCL_19346495_ChIP-Seq_HPC-7_Human2.26739999
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26076138
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.24105861
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24079279
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22921637
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21400735
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20560831
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19766246
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19766246
30VDR_22108803_ChIP-Seq_LS180_Human2.19010942
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.16954194
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16932351
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09681250
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.08759107
35MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07857304
36BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06142077
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05252627
38* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.04091694
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03329065
40CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02834226
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00308079
42* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94977932
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94594923
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.93080371
45* SRF_21415370_ChIP-Seq_HL-1_Mouse1.91166214
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90585914
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.89941297
48FUS_26573619_Chip-Seq_HEK293_Human1.89637622
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86086575
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.85607848
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.85506043
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85047841
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.83850775
54ER_23166858_ChIP-Seq_MCF-7_Human1.81784285
55VDR_21846776_ChIP-Seq_THP-1_Human1.81558128
56SPI1_23547873_ChIP-Seq_NB4_Human1.80937174
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80031658
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79301200
59P300_19829295_ChIP-Seq_ESCs_Human1.78175974
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78137398
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76670654
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75406495
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.73717256
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.73234995
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72592195
66BCL6_27268052_Chip-Seq_Bcells_Human1.71585513
67REST_21632747_ChIP-Seq_MESCs_Mouse1.71501858
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.70863704
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67773876
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67435868
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65294356
72AR_21572438_ChIP-Seq_LNCaP_Human1.64482978
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61618540
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60531426
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.59751911
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56578149
77UTX_26944678_Chip-Seq_JUKART_Human1.55728366
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53913528
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52572579
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50943741
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50673383
82VDR_24763502_ChIP-Seq_THP-1_Human1.50083905
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.49384199
84ZNF263_19887448_ChIP-Seq_K562_Human1.47868831
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46135382
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45958442
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44864059
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44424343
89* RUNX1_22412390_ChIP-Seq_EML_Mouse1.44031713
90MYB_26560356_Chip-Seq_TH2_Human1.42208262
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42136728
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40647754
93SMAD4_21799915_ChIP-Seq_A2780_Human1.40224208
94BCOR_27268052_Chip-Seq_Bcells_Human1.38888951
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38740569
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.38200330
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37591178
98RNF2_27304074_Chip-Seq_NSC_Mouse1.35865336
99EST1_17652178_ChIP-ChIP_JURKAT_Human1.35806065
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.33698447
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33374082
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.33060520
103FOXP3_21729870_ChIP-Seq_TREG_Human1.32697348
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.32469206
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.31901860
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31647524
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30984909
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29439794
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29280231
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27857174
111GABP_19822575_ChIP-Seq_HepG2_Human1.27847971
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27635060
113* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27241729
114CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25803650
115* NANOG_18555785_Chip-Seq_ESCs_Mouse1.25429912
116CIITA_25753668_ChIP-Seq_RAJI_Human1.25035853
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.24152848
118* VDR_23849224_ChIP-Seq_CD4+_Human1.24133851
119DROSHA_22980978_ChIP-Seq_HELA_Human1.24014630
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23722529
121PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23712060
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23630677
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23571189
124P68_20966046_ChIP-Seq_HELA_Human1.23538907
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23388237
126MAF_26560356_Chip-Seq_TH1_Human1.23196972
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.22399372
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20910671
129CTCF_26484167_Chip-Seq_Bcells_Mouse1.20898112
130* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20694428
131STAT1_20625510_ChIP-Seq_HELA_Human1.20383289
132SPI1_20517297_ChIP-Seq_HL60_Human1.20289303
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18613902
134* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18272947
135SPI1_23127762_ChIP-Seq_K562_Human1.17311021
136* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17181071
137MYC_22102868_ChIP-Seq_BL_Human1.16032414
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15970740
139LXR_22292898_ChIP-Seq_THP-1_Human1.15286675
140FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15099393
141* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14566982
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14384482
143* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14233025
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13919967
145BP1_19119308_ChIP-ChIP_Hs578T_Human1.13781489
146BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13591307
147EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12716354
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12590245
149P300_27268052_Chip-Seq_Bcells_Human1.12490683
150CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11185138
151MAF_26560356_Chip-Seq_TH2_Human1.11087954
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10776194
153YY1_22570637_ChIP-Seq_MALME-3M_Human1.10675348
154* CMYC_18555785_Chip-Seq_ESCs_Mouse1.09716678
155CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09645461
156JUN_21703547_ChIP-Seq_K562_Human1.09610443
157RUNX2_22187159_ChIP-Seq_PCA_Human1.09533323
158ELK3_25401928_ChIP-Seq_HUVEC_Human1.09393031
159EWS_26573619_Chip-Seq_HEK293_Human1.07871554
160YY1_21170310_ChIP-Seq_MESCs_Mouse1.07166235
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06621549
162ZNF274_21170338_ChIP-Seq_K562_Hela1.06496787
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06057665
164PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05491907
165CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05485642
166TAL1_26923725_Chip-Seq_HPCs_Mouse1.05222250
167RARB_27405468_Chip-Seq_BRAIN_Mouse1.04585616
168E2F1_20622854_ChIP-Seq_HELA_Human1.03691023
169MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03566372
170CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03107053
171* P300_18555785_Chip-Seq_ESCs_Mouse1.02528004
172SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02295309
173* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01990989
174RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01291194
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01159678
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01159678
177* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01102509
178MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99576090
179* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99418602
180FLI1_27457419_Chip-Seq_LIVER_Mouse0.98770855
181AR_25329375_ChIP-Seq_VCAP_Human0.97968969
182* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97405035
183* P53_22387025_ChIP-Seq_ESCs_Mouse0.96769856
184KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96642815
185KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96642815
186KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96642815
187IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96451464
188AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95566052
189KDM2B_26808549_Chip-Seq_REH_Human0.95242876
190KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92394459
191P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92233225
192* TCF4_23295773_ChIP-Seq_U87_Human0.91965650
193ERG_21242973_ChIP-ChIP_JURKAT_Human0.91389701
194STAT3_23295773_ChIP-Seq_U87_Human0.91277704
195* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91210556
196TP53_18474530_ChIP-ChIP_U2OS_Human0.91033926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.82948831
2MP0005464_abnormal_platelet_physiology4.82274084
3MP0004270_analgesia3.73983955
4MP0000465_gastrointestinal_hemorrhage3.71248454
5MP0001529_abnormal_vocalization3.30707224
6MP0003806_abnormal_nucleotide_metabolis3.24968590
7MP0005058_abnormal_lysosome_morphology3.24676592
8MP0003724_increased_susceptibility_to3.16368126
9MP0001905_abnormal_dopamine_level3.04956205
10MP0000920_abnormal_myelination3.03909381
11MP0001835_abnormal_antigen_presentation2.92766004
12MP0002148_abnormal_hypersensitivity_rea2.92479487
13MP0009278_abnormal_bone_marrow2.85397752
14MP0004859_abnormal_synaptic_plasticity2.84299529
15MP0003436_decreased_susceptibility_to2.81676089
16MP0002064_seizures2.69663744
17MP0005397_hematopoietic_system_phenotyp2.68088420
18MP0001545_abnormal_hematopoietic_system2.68088420
19MP0005409_darkened_coat_color2.60075599
20MP0009745_abnormal_behavioral_response2.58520001
21MP0003635_abnormal_synaptic_transmissio2.57893250
22MP0002272_abnormal_nervous_system2.56600234
23MP0003303_peritoneal_inflammation2.51676349
24MP0001440_abnormal_grooming_behavior2.45542665
25MP0005423_abnormal_somatic_nervous2.40751203
26MP0006276_abnormal_autonomic_nervous2.40696657
27MP0003136_yellow_coat_color2.40042090
28MP0005671_abnormal_response_to2.39308532
29MP0005000_abnormal_immune_tolerance2.36550843
30MP0001486_abnormal_startle_reflex2.35699736
31MP0002734_abnormal_mechanical_nocicepti2.30912404
32MP0005171_absent_coat_pigmentation2.24698796
33MP0004742_abnormal_vestibular_system2.21716310
34MP0001968_abnormal_touch/_nociception2.21630388
35MP0009379_abnormal_foot_pigmentation2.21508165
36MP0003329_amyloid_beta_deposits2.18316492
37MP0009046_muscle_twitch2.17470760
38MP0003186_abnormal_redox_activity2.17008643
39MP0000778_abnormal_nervous_system2.15839148
40MP0006036_abnormal_mitochondrial_physio2.14924420
41MP0002572_abnormal_emotion/affect_behav2.14868695
42MP0009764_decreased_sensitivity_to2.14791581
43MP0005025_abnormal_response_to2.09405814
44MP0004142_abnormal_muscle_tone2.08250725
45MP0005084_abnormal_gallbladder_morpholo2.07431090
46MP0009785_altered_susceptibility_to2.05592845
47MP0002063_abnormal_learning/memory/cond2.01427017
48MP0002736_abnormal_nociception_after2.01214815
49MP0002419_abnormal_innate_immunity1.99752253
50MP0002735_abnormal_chemical_nociception1.99134814
51MP0000343_altered_response_to1.94340210
52MP0002452_abnormal_antigen_presenting1.91915447
53MP0002723_abnormal_immune_serum1.88230671
54MP0002420_abnormal_adaptive_immunity1.87546877
55MP0001819_abnormal_immune_cell1.86244066
56MP0003075_altered_response_to1.84727056
57MP0008004_abnormal_stomach_pH1.83882846
58MP0001970_abnormal_pain_threshold1.82063012
59MP0001800_abnormal_humoral_immune1.81738108
60MP0003191_abnormal_cellular_cholesterol1.76940588
61MP0002733_abnormal_thermal_nociception1.76557969
62MP0001533_abnormal_skeleton_physiology1.73727608
63MP0004145_abnormal_muscle_electrophysio1.73658098
64MP0001501_abnormal_sleep_pattern1.73215954
65MP0003690_abnormal_glial_cell1.73027156
66MP0004885_abnormal_endolymph1.70062146
67MP0001485_abnormal_pinna_reflex1.68875620
68MP0002398_abnormal_bone_marrow1.68464394
69MP0002067_abnormal_sensory_capabilities1.67695118
70MP0002184_abnormal_innervation1.56792740
71MP0000689_abnormal_spleen_morphology1.56502470
72MP0000716_abnormal_immune_system1.50347099
73MP0008875_abnormal_xenobiotic_pharmacok1.49127333
74MP0003634_abnormal_glial_cell1.49053429
75MP0005165_increased_susceptibility_to1.47146856
76MP0001853_heart_inflammation1.45988083
77MP0005551_abnormal_eye_electrophysiolog1.45504404
78MP0002429_abnormal_blood_cell1.44294045
79MP0010155_abnormal_intestine_physiology1.44193997
80MP0001790_abnormal_immune_system1.43730417
81MP0005387_immune_system_phenotype1.43730417
82MP0006082_CNS_inflammation1.40909776
83MP0002722_abnormal_immune_system1.40342465
84MP0005386_behavior/neurological_phenoty1.39874713
85MP0004924_abnormal_behavior1.39874713
86MP0002837_dystrophic_cardiac_calcinosis1.39021879
87MP0005410_abnormal_fertilization1.38366327
88MP0000955_abnormal_spinal_cord1.37491219
89MP0008260_abnormal_autophagy1.37092973
90MP0001845_abnormal_inflammatory_respons1.36756773
91MP0002882_abnormal_neuron_morphology1.35341003
92MP0000685_abnormal_immune_system1.32829251
93MP0003763_abnormal_thymus_physiology1.31901811
94MP0002229_neurodegeneration1.30747314
95MP0009333_abnormal_splenocyte_physiolog1.30072661
96MP0003632_abnormal_nervous_system1.28793534
97MP0002066_abnormal_motor_capabilities/c1.27492330
98MP0000462_abnormal_digestive_system1.24626150
99MP0003950_abnormal_plasma_membrane1.24095944
100MP0002557_abnormal_social/conspecific_i1.23751068
101MP0008469_abnormal_protein_level1.23467459
102MP0002405_respiratory_system_inflammati1.22344074
103MP0009840_abnormal_foam_cell1.22001421
104MP0004381_abnormal_hair_follicle1.20719966
105MP0004147_increased_porphyrin_level1.20484458
106MP0002752_abnormal_somatic_nervous1.20394189
107MP0003656_abnormal_erythrocyte_physiolo1.20273617
108MP0001963_abnormal_hearing_physiology1.19657770
109MP0001188_hyperpigmentation1.18956893
110MP0002822_catalepsy1.16874792
111MP0005379_endocrine/exocrine_gland_phen1.15831872
112MP0009763_increased_sensitivity_to1.15716891
113MP0001663_abnormal_digestive_system1.14362528
114MP0003638_abnormal_response/metabolism_1.13028425
115MP0001984_abnormal_olfaction1.10483592
116MP0009697_abnormal_copulation1.10345384
117MP0000604_amyloidosis1.06095183
118MP0005083_abnormal_biliary_tract1.04964820
119MP0006035_abnormal_mitochondrial_morpho1.04861928
120MP0003866_abnormal_defecation1.04505205
121MP0003631_nervous_system_phenotype1.02832936
122MP0000858_altered_metastatic_potential1.02401200
123MP0006072_abnormal_retinal_apoptosis1.01619050
124MP0005075_abnormal_melanosome_morpholog1.01255562
125MP0003938_abnormal_ear_development1.01111653
126MP0001542_abnormal_bone_strength0.99194661
127MP0002019_abnormal_tumor_incidence0.98656548
128MP0005645_abnormal_hypothalamus_physiol0.95062079
129MP0008569_lethality_at_weaning0.93661185
130MP0000230_abnormal_systemic_arterial0.93472696
131MP0003172_abnormal_lysosome_physiology0.93323692
132MP0001661_extended_life_span0.92770322
133MP0000026_abnormal_inner_ear0.92709556
134MP0005166_decreased_susceptibility_to0.92478062
135MP0005584_abnormal_enzyme/coenzyme_acti0.92281680
136MP0009765_abnormal_xenobiotic_induced0.90779460
137MP0004510_myositis0.89867801
138MP0005167_abnormal_blood-brain_barrier0.89098393
139MP0002938_white_spotting0.88538409
140MP0004947_skin_inflammation0.88040937
141MP0001727_abnormal_embryo_implantation0.87080881
142MP0002139_abnormal_hepatobiliary_system0.86896678
143MP0005319_abnormal_enzyme/_coenzyme0.86821760
144MP0002102_abnormal_ear_morphology0.86543719
145MP0002152_abnormal_brain_morphology0.86291329
146MP0000490_abnormal_crypts_of0.86031680
147MP0002295_abnormal_pulmonary_circulatio0.84823269
148MP0001873_stomach_inflammation0.84809038
149MP0000631_abnormal_neuroendocrine_gland0.84431691
150MP0000681_abnormal_thyroid_gland0.83916400
151MP0008058_abnormal_DNA_repair0.83445795
152MP0005253_abnormal_eye_physiology0.83290851
153MP0000358_abnormal_cell_content/0.82845313
154MP0005195_abnormal_posterior_eye0.82743980
155MP0003633_abnormal_nervous_system0.82146174
156MP0002132_abnormal_respiratory_system0.81714699
157MP0005390_skeleton_phenotype0.81135415
158MP0006054_spinal_hemorrhage0.81044054
159MP0004134_abnormal_chest_morphology0.80716549
160MP0008873_increased_physiological_sensi0.80606540
161MP0001502_abnormal_circadian_rhythm0.79603817
162MP0005623_abnormal_meninges_morphology0.79296526
163MP0003718_maternal_effect0.77492858
164MP0000703_abnormal_thymus_morphology0.74906238
165MP0003122_maternal_imprinting0.74362063
166MP0002751_abnormal_autonomic_nervous0.72827869
167MP0001664_abnormal_digestion0.71716575
168MP0002653_abnormal_ependyma_morphology0.70548125
169MP0005381_digestive/alimentary_phenotyp0.69240012
170MP0002876_abnormal_thyroid_physiology0.67420605
171MP0002090_abnormal_vision0.66705141
172MP0002163_abnormal_gland_morphology0.66321218
173MP0003828_pulmonary_edema0.66271236
174MP0002332_abnormal_exercise_endurance0.65158471
175MP0005451_abnormal_body_composition0.64653100
176MP0001851_eye_inflammation0.64181803
177MP0004811_abnormal_neuron_physiology0.63511562
178MP0002069_abnormal_eating/drinking_beha0.63460868
179MP0001764_abnormal_homeostasis0.62649250
180MP0001943_abnormal_respiration0.62388085
181MP0005636_abnormal_mineral_homeostasis0.62352539
182MP0002998_abnormal_bone_remodeling0.61919343
183MP0005408_hypopigmentation0.61788958
184MP0000762_abnormal_tongue_morphology0.58794592
185MP0004858_abnormal_nervous_system0.58059366
186MP0008874_decreased_physiological_sensi0.57711228
187MP0006292_abnormal_olfactory_placode0.57698285
188MP0010386_abnormal_urinary_bladder0.57138605
189MP0008872_abnormal_physiological_respon0.56653722
190MP0005646_abnormal_pituitary_gland0.56361463
191MP0003137_abnormal_impulse_conducting0.54782662
192MP0002638_abnormal_pupillary_reflex0.54632536
193MP0004085_abnormal_heartbeat0.54323067

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.49313755
2Prolonged bleeding time (HP:0003010)4.76784111
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.70067185
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.70067185
5Neurofibrillary tangles (HP:0002185)4.65787502
6Purpura (HP:0000979)4.50071065
7Sensory axonal neuropathy (HP:0003390)4.43109607
8Cerebral inclusion bodies (HP:0100314)4.11164686
9Acute necrotizing encephalopathy (HP:0006965)4.00684784
10Focal motor seizures (HP:0011153)3.97041701
11Parakeratosis (HP:0001036)3.90160554
12Elevated erythrocyte sedimentation rate (HP:0003565)3.81603236
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.74497867
14Epistaxis (HP:0000421)3.72300160
15Atonic seizures (HP:0010819)3.64472546
16Renal Fanconi syndrome (HP:0001994)3.63031819
17Abnormality of the corticospinal tract (HP:0002492)3.57915179
18Increased hepatocellular lipid droplets (HP:0006565)3.57025507
19Mitochondrial inheritance (HP:0001427)3.46236270
20Myokymia (HP:0002411)3.43862293
21Abnormality of liposaccharide metabolism (HP:0010968)3.43425302
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.43425302
23Abnormality of glycolipid metabolism (HP:0010969)3.43425302
24Progressive macrocephaly (HP:0004481)3.41422837
25Increased IgM level (HP:0003496)3.36916849
26Peripheral hypomyelination (HP:0007182)3.33388982
27Abnormal mitochondria in muscle tissue (HP:0008316)3.30050046
28Agammaglobulinemia (HP:0004432)3.26279103
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14624644
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14624644
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.11998983
32Acute encephalopathy (HP:0006846)3.08703264
33Chronic obstructive pulmonary disease (HP:0006510)3.05573800
34Obstructive lung disease (HP:0006536)3.05573800
35Menorrhagia (HP:0000132)3.05531070
36Stomatitis (HP:0010280)3.05412002
37Abnormality of the heme biosynthetic pathway (HP:0010472)3.05052571
38Leukodystrophy (HP:0002415)2.97696765
39Focal seizures (HP:0007359)2.96118729
40Lipid accumulation in hepatocytes (HP:0006561)2.94426887
41Increased serum pyruvate (HP:0003542)2.88038889
42Abnormality of glycolysis (HP:0004366)2.88038889
43Increased mean platelet volume (HP:0011877)2.85595922
44Abnormal platelet volume (HP:0011876)2.85121334
45Retinal dysplasia (HP:0007973)2.84862194
46Hepatic necrosis (HP:0002605)2.84430394
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82457286
48Cerebral palsy (HP:0100021)2.81757863
49Thrombocytosis (HP:0001894)2.79352498
50Increased serum ferritin (HP:0003281)2.79089405
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78052433
52Dicarboxylic aciduria (HP:0003215)2.78052433
53Vacuolated lymphocytes (HP:0001922)2.75820847
54Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72869398
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.71939401
56Optic disc pallor (HP:0000543)2.71718519
57Increased cerebral lipofuscin (HP:0011813)2.70503125
58Myositis (HP:0100614)2.68552541
59Dysostosis multiplex (HP:0000943)2.68443365
60Termporal pattern (HP:0011008)2.66926577
61Insidious onset (HP:0003587)2.66926577
62Autoimmune thrombocytopenia (HP:0001973)2.63619148
63Increased CSF lactate (HP:0002490)2.62180367
64Cerebral hemorrhage (HP:0001342)2.61594818
65Gingival bleeding (HP:0000225)2.59103990
66Congenital ichthyosiform erythroderma (HP:0007431)2.58574774
67Dysmetria (HP:0001310)2.56116406
68Abnormal platelet function (HP:0011869)2.55173786
69Impaired platelet aggregation (HP:0003540)2.55173786
70Supranuclear gaze palsy (HP:0000605)2.54449913
71Increased intramyocellular lipid droplets (HP:0012240)2.54034445
72Hypertensive crisis (HP:0100735)2.52845019
73Abnormality of macrophages (HP:0004311)2.52317816
74Panhypogammaglobulinemia (HP:0003139)2.52255135
75Abnormality of lateral ventricle (HP:0030047)2.49164711
76Ragged-red muscle fibers (HP:0003200)2.49108666
77Abnormality of iron homeostasis (HP:0011031)2.46905313
78Dialeptic seizures (HP:0011146)2.45179432
79Epileptic encephalopathy (HP:0200134)2.41240806
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41158831
81Limb dystonia (HP:0002451)2.40642794
82Visual hallucinations (HP:0002367)2.39845499
83Abnormality of the prostate (HP:0008775)2.37076460
84Abnormal ciliary motility (HP:0012262)2.36320419
85Spastic gait (HP:0002064)2.35541017
86Absence seizures (HP:0002121)2.34125627
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.33049420
88Absent/shortened dynein arms (HP:0200106)2.33049420
89Abnormality of renal resorption (HP:0011038)2.31374389
90Hepatocellular necrosis (HP:0001404)2.31263041
91Autoimmune hemolytic anemia (HP:0001890)2.27615973
92Hypothermia (HP:0002045)2.26968946
93Granulocytopenia (HP:0001913)2.25920021
94Type I transferrin isoform profile (HP:0003642)2.24623668
95Pheochromocytoma (HP:0002666)2.24288301
96Hyperventilation (HP:0002883)2.23379020
97Febrile seizures (HP:0002373)2.22141834
98Mediastinal lymphadenopathy (HP:0100721)2.21467142
99Lactic acidosis (HP:0003128)2.21382803
100Hypergammaglobulinemia (HP:0010702)2.20844706
101Progressive cerebellar ataxia (HP:0002073)2.20673345
102Alacrima (HP:0000522)2.20631916
103Broad-based gait (HP:0002136)2.19950205
104Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18627584
105Prolonged neonatal jaundice (HP:0006579)2.18213567
106Neuroendocrine neoplasm (HP:0100634)2.17970769
107Severe combined immunodeficiency (HP:0004430)2.17958322
1083-Methylglutaconic aciduria (HP:0003535)2.16495936
109Methylmalonic aciduria (HP:0012120)2.14898740
110Cupped ear (HP:0000378)2.12494635
111Abnormality of transition element cation homeostasis (HP:0011030)2.11190303
112Vaginal atresia (HP:0000148)2.10494549
113Abnormal respiratory motile cilium physiology (HP:0012261)2.08931384
114Aplastic anemia (HP:0001915)2.06526283
115Opisthotonus (HP:0002179)2.06386390
116Abnormality of the parathyroid morphology (HP:0011766)2.06065428
117Genital tract atresia (HP:0001827)2.04623456
118Delusions (HP:0000746)2.04552865
119Progressive microcephaly (HP:0000253)2.02176237
120Medial flaring of the eyebrow (HP:0010747)2.01632100
121Abnormal protein glycosylation (HP:0012346)2.01523311
122Abnormal glycosylation (HP:0012345)2.01523311
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01523311
124Abnormal protein N-linked glycosylation (HP:0012347)2.01523311
125Abnormality of B cell number (HP:0010975)2.01303254
126Respiratory failure (HP:0002878)1.99312255
127Encephalitis (HP:0002383)1.98959720
128Abnormal respiratory epithelium morphology (HP:0012253)1.98834532
129Abnormal respiratory motile cilium morphology (HP:0005938)1.98834532
130Meningitis (HP:0001287)1.98668943
131Cerebral hypomyelination (HP:0006808)1.97812288
132Recurrent abscess formation (HP:0002722)1.96902294
133Akinesia (HP:0002304)1.94794487
134Abnormality of the axillary hair (HP:0100134)1.93959387
135Abnormality of secondary sexual hair (HP:0009888)1.93959387
136Generalized aminoaciduria (HP:0002909)1.93509981
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.93374939
138Overfolded helix (HP:0000396)1.93187390
139Exertional dyspnea (HP:0002875)1.92857105
140Microvesicular hepatic steatosis (HP:0001414)1.92760619
141Onion bulb formation (HP:0003383)1.92241122
142IgG deficiency (HP:0004315)1.92118951
143Cerebral edema (HP:0002181)1.91665530
144Growth hormone excess (HP:0000845)1.91264008
145Anomalous pulmonary venous return (HP:0010772)1.90314361
146Centrally nucleated skeletal muscle fibers (HP:0003687)1.89741100
147Patchy hypopigmentation of hair (HP:0011365)1.88746233
148Nasolacrimal duct obstruction (HP:0000579)1.88421950
149White forelock (HP:0002211)1.87386016
150Generalized tonic-clonic seizures (HP:0002069)1.87323226
151Rhabdomyolysis (HP:0003201)1.86614803
152Increased muscle lipid content (HP:0009058)1.86611458
153Pulmonary fibrosis (HP:0002206)1.86093343
154Respiratory difficulties (HP:0002880)1.85372852
155Intention tremor (HP:0002080)1.84938373
156Increased circulating renin level (HP:0000848)1.84875592
157Hepatosplenomegaly (HP:0001433)1.84636830
158Combined immunodeficiency (HP:0005387)1.84590569
159Exercise intolerance (HP:0003546)1.84254490
160Reduced antithrombin III activity (HP:0001976)1.83932470
161Progressive neurologic deterioration (HP:0002344)1.83895279
162Emotional lability (HP:0000712)1.83736110
163Abnormal hair whorl (HP:0010721)1.83450531
164Increased serum lactate (HP:0002151)1.82826516
165B lymphocytopenia (HP:0010976)1.82818317
166Gait imbalance (HP:0002141)1.82724296
167X-linked dominant inheritance (HP:0001423)1.82719053
168Chin dimple (HP:0010751)1.82551126
169Autoamputation (HP:0001218)1.80979979
170Paralysis (HP:0003470)1.80866135
171Hypomagnesemia (HP:0002917)1.80744726
172Vertebral compression fractures (HP:0002953)1.80342634
173Generalized myoclonic seizures (HP:0002123)1.80169025
174Abnormal pupillary function (HP:0007686)1.77665233
175Muscle hypertrophy of the lower extremities (HP:0008968)1.77501953
176Esotropia (HP:0000565)1.76120708
177Anxiety (HP:0000739)1.75794350
178Abnormality of incisor morphology (HP:0011063)1.73571735
179Polyphagia (HP:0002591)1.72898768
180Spastic paraparesis (HP:0002313)1.71094337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.39537841
2PNCK3.78967081
3NME23.78450452
4TESK23.65019551
5BCKDK3.59801211
6VRK23.39302462
7KDR3.32639607
8TESK13.16768122
9TNIK3.13649145
10OXSR12.98755435
11CASK2.97635567
12EPHA42.86386682
13MAP3K112.83143224
14SCYL22.71981226
15PIM22.62350182
16TAOK32.23698130
17FES2.17807443
18MAP4K12.16262045
19GRK52.05532146
20MAPKAPK52.04492800
21NTRK32.01985031
22FGR2.00674325
23MST41.98031678
24RIPK41.96150940
25TBK11.91760638
26EPHB11.91478908
27WNK41.89303089
28MARK11.80345278
29PKN11.78833665
30NME11.78498542
31KIT1.75618748
32BCR1.75301327
33GRK71.69093806
34PBK1.65395327
35CDK191.65013499
36CSNK1G31.63449818
37NTRK11.57985013
38DAPK11.49043799
39CAMK2B1.44412804
40UHMK11.44033780
41ARAF1.42332517
42CSF1R1.41921212
43TYRO31.40931775
44MAP3K41.39441192
45TEC1.39376961
46MAP3K121.38328199
47SYK1.37705724
48MAPK131.34623496
49BTK1.33999865
50ERN11.28310993
51TXK1.27511171
52IRAK21.26135542
53MATK1.25812339
54CSNK1G21.23255865
55MAP2K71.22975819
56IKBKB1.22757886
57BMPR21.20430610
58ROCK21.20266436
59CAMK2A1.19205861
60ADRBK21.18658185
61PTK2B1.17427891
62JAK31.17363455
63CSNK1A1L1.16303462
64CSNK1G11.15963205
65CAMK2D1.15280330
66ZAP701.14610914
67TAOK21.14563577
68PLK21.14306994
69LIMK11.10853365
70MAP4K21.07606662
71MAPKAPK31.07144006
72STK161.06146701
73NEK61.04806686
74MUSK1.03882973
75MAP2K31.03737845
76IRAK31.03500885
77MAP3K141.01261270
78MAP3K90.99958575
79FLT30.99434220
80NUAK10.99288334
81WNK10.93571963
82CDK50.93490091
83MAP3K50.91893190
84TIE10.90687000
85LYN0.87357224
86MINK10.86213748
87BMX0.86025933
88IKBKE0.84567016
89MAPK150.84021837
90MAP2K40.80492560
91DYRK20.80280138
92PRKCQ0.79717721
93MET0.76887376
94DAPK30.76824222
95BMPR1B0.76012011
96CDK140.75367303
97PRKCE0.74673510
98TNK20.74619577
99CAMK2G0.74434046
100PIK3CG0.74317980
101ZAK0.74078571
102LCK0.73470905
103ADRBK10.73100810
104NTRK20.71039665
105PAK10.71037170
106EIF2AK10.70273135
107MAP2K20.70056420
108ILK0.69661053
109GRK60.68999414
110CCNB10.67491442
111FGFR20.67303129
112IRAK10.66139485
113PAK60.64962463
114ITK0.64113104
115HCK0.62200977
116ABL20.61520731
117DYRK1B0.60921911
118CDK150.59090294
119LRRK20.58730550
120ICK0.58557859
121CDK180.56710026
122DYRK1A0.56626461
123FYN0.55792230
124PAK30.54968702
125CDK11A0.54502262
126PRKACA0.53624722
127PRKCG0.52689330
128MAP3K20.51294818
129PIM10.50966357
130CLK10.50858661
131BLK0.50822970
132TYK20.50790855
133MOS0.47954842
134CDK80.47634983
135AURKA0.46207765
136MAP3K130.44588616
137KSR20.44010916
138TGFBR20.43565210
139PRKG10.40869039
140CAMK1G0.39979354
141STK100.39537551
142PHKG20.39156906
143PHKG10.39156906
144PRKD20.38520801
145MARK20.37254597
146TLK10.37038734
147CSNK1E0.36525859
148RPS6KA50.36518948
149DAPK20.35374578
150MAPK120.35362546
151PRKCD0.35359958
152ERBB40.34084690
153WNK30.33824438
154MYLK0.32833580
155IGF1R0.32795565
156SGK4940.32624530
157SGK2230.32624530
158RPS6KA40.31217005
159PINK10.30736938
160VRK10.30637013
161CSNK1A10.30581711
162PRKD10.29869672
163DYRK30.29392331
164SGK10.29384183
165MAP3K60.28490355
166CSNK2A10.28334358
167PRKCA0.27476196

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.62648376
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.12731746
3Parkinsons disease_Homo sapiens_hsa050123.52622797
4Alzheimers disease_Homo sapiens_hsa050103.17157180
5Asthma_Homo sapiens_hsa053102.93017065
6Steroid biosynthesis_Homo sapiens_hsa001002.73348974
7Allograft rejection_Homo sapiens_hsa053302.68524678
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60164189
9Nicotine addiction_Homo sapiens_hsa050332.56434721
10Primary immunodeficiency_Homo sapiens_hsa053402.51019038
11Fatty acid elongation_Homo sapiens_hsa000622.46024614
12Huntingtons disease_Homo sapiens_hsa050162.45952476
13Collecting duct acid secretion_Homo sapiens_hsa049662.42107526
14Graft-versus-host disease_Homo sapiens_hsa053322.27264799
15Base excision repair_Homo sapiens_hsa034102.27126051
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.24299673
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11051744
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08797457
19Ether lipid metabolism_Homo sapiens_hsa005652.04834107
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03957785
21Serotonergic synapse_Homo sapiens_hsa047262.01212944
22Glutamatergic synapse_Homo sapiens_hsa047241.99589250
23Cardiac muscle contraction_Homo sapiens_hsa042601.89568480
24DNA replication_Homo sapiens_hsa030301.74781022
25Type I diabetes mellitus_Homo sapiens_hsa049401.74634005
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73870286
27GABAergic synapse_Homo sapiens_hsa047271.71164168
28Protein export_Homo sapiens_hsa030601.70997936
29Pentose phosphate pathway_Homo sapiens_hsa000301.65140937
30Other glycan degradation_Homo sapiens_hsa005111.63492450
31Antigen processing and presentation_Homo sapiens_hsa046121.63408280
32Pyrimidine metabolism_Homo sapiens_hsa002401.60408857
33Long-term depression_Homo sapiens_hsa047301.56505290
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55991093
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.55166216
36Axon guidance_Homo sapiens_hsa043601.54119061
37Morphine addiction_Homo sapiens_hsa050321.54046722
38Shigellosis_Homo sapiens_hsa051311.53884933
39Caffeine metabolism_Homo sapiens_hsa002321.53536825
40Ribosome_Homo sapiens_hsa030101.50968657
41Taste transduction_Homo sapiens_hsa047421.49908385
42Synaptic vesicle cycle_Homo sapiens_hsa047211.48643210
43Leishmaniasis_Homo sapiens_hsa051401.48448765
44Vibrio cholerae infection_Homo sapiens_hsa051101.48054230
45Viral myocarditis_Homo sapiens_hsa054161.47504953
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42501039
47Lysosome_Homo sapiens_hsa041421.39515332
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39129525
49Amphetamine addiction_Homo sapiens_hsa050311.38837876
50Phototransduction_Homo sapiens_hsa047441.38088210
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.37525554
52Rheumatoid arthritis_Homo sapiens_hsa053231.37180000
53Long-term potentiation_Homo sapiens_hsa047201.36631782
54Platelet activation_Homo sapiens_hsa046111.36150167
55Circadian entrainment_Homo sapiens_hsa047131.33540054
56Staphylococcus aureus infection_Homo sapiens_hsa051501.33446813
57Salivary secretion_Homo sapiens_hsa049701.29854265
58Dopaminergic synapse_Homo sapiens_hsa047281.29486548
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24564355
60Sulfur metabolism_Homo sapiens_hsa009201.24163623
61Peroxisome_Homo sapiens_hsa041461.22615836
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22292014
63Sulfur relay system_Homo sapiens_hsa041221.22186649
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20407902
65Cocaine addiction_Homo sapiens_hsa050301.10658375
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09729276
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09177797
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08301689
69Sphingolipid metabolism_Homo sapiens_hsa006001.07150546
70Renin secretion_Homo sapiens_hsa049241.06819898
71Cholinergic synapse_Homo sapiens_hsa047251.06286791
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02802879
73Mismatch repair_Homo sapiens_hsa034300.99494492
74Linoleic acid metabolism_Homo sapiens_hsa005910.95103236
75Purine metabolism_Homo sapiens_hsa002300.94466810
76Gastric acid secretion_Homo sapiens_hsa049710.93471106
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92869244
78Herpes simplex infection_Homo sapiens_hsa051680.91598450
79Carbon metabolism_Homo sapiens_hsa012000.91350028
80Tuberculosis_Homo sapiens_hsa051520.90073169
81Salmonella infection_Homo sapiens_hsa051320.89623906
82Legionellosis_Homo sapiens_hsa051340.89323017
83RNA polymerase_Homo sapiens_hsa030200.89308496
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.88854436
85Calcium signaling pathway_Homo sapiens_hsa040200.88759913
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88504656
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88083445
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87332906
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85964699
90Proteasome_Homo sapiens_hsa030500.85670746
91Homologous recombination_Homo sapiens_hsa034400.82261441
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80160565
93Pertussis_Homo sapiens_hsa051330.79305250
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78919904
95Oxytocin signaling pathway_Homo sapiens_hsa049210.78548306
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.76054188
97Butanoate metabolism_Homo sapiens_hsa006500.75540859
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75167054
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72890704
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.72335105
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71796207
102Osteoclast differentiation_Homo sapiens_hsa043800.71065051
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70162734
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69542460
105Malaria_Homo sapiens_hsa051440.67680005
106Olfactory transduction_Homo sapiens_hsa047400.66147908
107Regulation of autophagy_Homo sapiens_hsa041400.65485148
108Gap junction_Homo sapiens_hsa045400.62499532
109GnRH signaling pathway_Homo sapiens_hsa049120.62420368
110Vitamin B6 metabolism_Homo sapiens_hsa007500.62151397
111African trypanosomiasis_Homo sapiens_hsa051430.61916527
112Pancreatic secretion_Homo sapiens_hsa049720.61786406
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60494717
114Histidine metabolism_Homo sapiens_hsa003400.60337236
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.55875198
116Insulin secretion_Homo sapiens_hsa049110.55730784
117Apoptosis_Homo sapiens_hsa042100.54719231
118Arachidonic acid metabolism_Homo sapiens_hsa005900.53860159
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.53750801
120Galactose metabolism_Homo sapiens_hsa000520.53372760
121Influenza A_Homo sapiens_hsa051640.53269927
122Renal cell carcinoma_Homo sapiens_hsa052110.52766733
123B cell receptor signaling pathway_Homo sapiens_hsa046620.52142675
124Tyrosine metabolism_Homo sapiens_hsa003500.51963317
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51884020
126Endocytosis_Homo sapiens_hsa041440.49395245
127Epstein-Barr virus infection_Homo sapiens_hsa051690.49264535
128Phagosome_Homo sapiens_hsa041450.48530941
129Ras signaling pathway_Homo sapiens_hsa040140.47787358
130Melanogenesis_Homo sapiens_hsa049160.47771498
131Choline metabolism in cancer_Homo sapiens_hsa052310.47685197
132Ovarian steroidogenesis_Homo sapiens_hsa049130.47072671
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46410478
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46329811
135Toxoplasmosis_Homo sapiens_hsa051450.46205785
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44920631
137Metabolic pathways_Homo sapiens_hsa011000.44745198
138Nucleotide excision repair_Homo sapiens_hsa034200.42921992
139Biosynthesis of amino acids_Homo sapiens_hsa012300.42688560
140cAMP signaling pathway_Homo sapiens_hsa040240.42512230
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41716325
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41488738
143Acute myeloid leukemia_Homo sapiens_hsa052210.40438291
144Prion diseases_Homo sapiens_hsa050200.40342117
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40165746
146Autoimmune thyroid disease_Homo sapiens_hsa053200.39719441
147Glutathione metabolism_Homo sapiens_hsa004800.36790482
148Spliceosome_Homo sapiens_hsa030400.36714158
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35821236
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35743890
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34872515
152Mineral absorption_Homo sapiens_hsa049780.34765638
153Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34399776
154Alcoholism_Homo sapiens_hsa050340.34035408
155Tryptophan metabolism_Homo sapiens_hsa003800.33951550
156Fructose and mannose metabolism_Homo sapiens_hsa000510.33478941
157Arginine and proline metabolism_Homo sapiens_hsa003300.31629367
158Dorso-ventral axis formation_Homo sapiens_hsa043200.30795193
159Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30392284
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.29641571
161Thyroid hormone synthesis_Homo sapiens_hsa049180.27157827
162Estrogen signaling pathway_Homo sapiens_hsa049150.26407156
163Hematopoietic cell lineage_Homo sapiens_hsa046400.25233169
164Tight junction_Homo sapiens_hsa045300.23658504
165cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21067503
166Pyruvate metabolism_Homo sapiens_hsa006200.20670064
167Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19508806
168ErbB signaling pathway_Homo sapiens_hsa040120.19099047
169Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18115864
170Phenylalanine metabolism_Homo sapiens_hsa003600.17922156

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