COMMD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.18968841
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00008369
3fatty acid elongation (GO:0030497)5.86249463
4ATP synthesis coupled proton transport (GO:0015986)5.83121515
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.83121515
6axon ensheathment in central nervous system (GO:0032291)5.72146591
7central nervous system myelination (GO:0022010)5.72146591
8respiratory electron transport chain (GO:0022904)5.28697638
9electron transport chain (GO:0022900)5.15063476
10protein neddylation (GO:0045116)5.06988062
11DNA deamination (GO:0045006)4.84222891
12chaperone-mediated protein transport (GO:0072321)4.68462769
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.27775779
14NADH dehydrogenase complex assembly (GO:0010257)4.27775779
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27775779
16aldehyde catabolic process (GO:0046185)4.17749811
17cholesterol biosynthetic process (GO:0006695)4.11454852
18signal peptide processing (GO:0006465)4.01923396
19long-chain fatty acid biosynthetic process (GO:0042759)3.97821695
20protein complex biogenesis (GO:0070271)3.96486723
21cytidine metabolic process (GO:0046087)3.70424521
22cytidine catabolic process (GO:0006216)3.70424521
23cytidine deamination (GO:0009972)3.70424521
24mannosylation (GO:0097502)3.63972232
25cytochrome complex assembly (GO:0017004)3.61977003
26response to redox state (GO:0051775)3.61044189
27sterol biosynthetic process (GO:0016126)3.55829939
28GPI anchor biosynthetic process (GO:0006506)3.45480991
29positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.44686714
30mitochondrial respiratory chain complex assembly (GO:0033108)3.43764005
31substantia nigra development (GO:0021762)3.43498641
32nucleotide transmembrane transport (GO:1901679)3.34233964
33myelination (GO:0042552)3.31332166
34amyloid precursor protein metabolic process (GO:0042982)3.29076590
35isoprenoid biosynthetic process (GO:0008299)3.28988185
36mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.28764612
37amyloid precursor protein catabolic process (GO:0042987)3.28584302
38ensheathment of neurons (GO:0007272)3.27831675
39axon ensheathment (GO:0008366)3.27831675
40positive regulation of cellular amine metabolic process (GO:0033240)3.23259609
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22798378
42pyrimidine ribonucleoside catabolic process (GO:0046133)3.21908683
43cofactor catabolic process (GO:0051187)3.19062063
44L-phenylalanine catabolic process (GO:0006559)3.15001530
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15001530
46GPI anchor metabolic process (GO:0006505)3.10795127
47hydrogen ion transmembrane transport (GO:1902600)3.10430335
48ribonucleoprotein complex disassembly (GO:0032988)3.09600081
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03901580
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03901580
51neutrophil activation involved in immune response (GO:0002283)3.01394100
52regulation of interleukin-8 secretion (GO:2000482)3.00717546
53preassembly of GPI anchor in ER membrane (GO:0016254)2.97228748
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96244537
55succinate metabolic process (GO:0006105)2.96223787
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95877505
57respiratory chain complex IV assembly (GO:0008535)2.95147255
58regulation of cellular amino acid metabolic process (GO:0006521)2.94348598
59proton transport (GO:0015992)2.94291200
60negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.93817330
61anterograde synaptic vesicle transport (GO:0048490)2.92172847
62fatty-acyl-CoA metabolic process (GO:0035337)2.90132187
63response to methylmercury (GO:0051597)2.89865782
64hydrogen transport (GO:0006818)2.88383939
65actin nucleation (GO:0045010)2.88202099
66long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.86397624
67axoneme assembly (GO:0035082)2.85313631
68negative regulation of protein localization to cell surface (GO:2000009)2.84479500
69positive regulation of interleukin-8 secretion (GO:2000484)2.84170931
70positive regulation of B cell differentiation (GO:0045579)2.83705284
71negative regulation of neurotransmitter transport (GO:0051589)2.83209663
72platelet dense granule organization (GO:0060155)2.81720384
73organelle disassembly (GO:1903008)2.80080592
74long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.78562363
75positive regulation of mitochondrial fission (GO:0090141)2.77562074
76regulation of collateral sprouting (GO:0048670)2.76748765
77regulation of metalloenzyme activity (GO:0048552)2.76311779
78base-excision repair, AP site formation (GO:0006285)2.73807856
79purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.73757752
80glycerophospholipid catabolic process (GO:0046475)2.72970599
81virion attachment to host cell (GO:0019062)2.72341479
82adhesion of symbiont to host cell (GO:0044650)2.72341479
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71719963
84aerobic respiration (GO:0009060)2.71420059
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71213448
86L-phenylalanine metabolic process (GO:0006558)2.70727807
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.70727807
88ATP biosynthetic process (GO:0006754)2.69724736
89proteasome assembly (GO:0043248)2.69237934
90piRNA metabolic process (GO:0034587)2.68554788
91peroxisome fission (GO:0016559)2.68257709
92membrane budding (GO:0006900)2.67118476
93C-terminal protein lipidation (GO:0006501)2.65491418
94glutathione biosynthetic process (GO:0006750)2.64763013
95deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63385658
96very long-chain fatty acid metabolic process (GO:0000038)2.63135282
97inositol phosphate catabolic process (GO:0071545)2.61909545
98negative regulation of neurotransmitter secretion (GO:0046929)2.60907516
99adenosine metabolic process (GO:0046085)2.60722664
100purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60602729
101purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.57741797
102dopamine transport (GO:0015872)2.57669701
103deoxyribose phosphate catabolic process (GO:0046386)2.56728271
104regulation of cellular amine metabolic process (GO:0033238)2.56276138
105cellular response to interferon-beta (GO:0035458)2.55952583
106phosphorylated carbohydrate dephosphorylation (GO:0046838)2.55814206
107inositol phosphate dephosphorylation (GO:0046855)2.55814206
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54537803
109glutathione derivative metabolic process (GO:1901685)2.54283118
110glutathione derivative biosynthetic process (GO:1901687)2.54283118
111creatine metabolic process (GO:0006600)2.54125838
112opsonization (GO:0008228)2.53713154
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.53679191
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.53315766
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52769236
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52769236
117RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52566509
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52535028
119cullin deneddylation (GO:0010388)2.52205648
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.50734528
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.50734528
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.50734528
123pyrimidine nucleotide catabolic process (GO:0006244)2.50254020
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50207941
125deoxyribose phosphate metabolic process (GO:0019692)2.49455503
126iron-sulfur cluster assembly (GO:0016226)2.49455073
127metallo-sulfur cluster assembly (GO:0031163)2.49455073
128positive regulation of protein homodimerization activity (GO:0090073)2.49122273
129immunoglobulin mediated immune response (GO:0016064)2.48621887
130coenzyme catabolic process (GO:0009109)2.48473010
131oxidative phosphorylation (GO:0006119)2.48444881
132regulation of catecholamine metabolic process (GO:0042069)2.48425271
133regulation of dopamine metabolic process (GO:0042053)2.48425271
134protein deneddylation (GO:0000338)2.48069362
135fatty-acyl-CoA biosynthetic process (GO:0046949)2.47866030
136glycolipid biosynthetic process (GO:0009247)2.47380708
137energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.47335858
138ATP hydrolysis coupled proton transport (GO:0015991)2.47335858
139amino acid salvage (GO:0043102)2.46535890
140L-methionine salvage (GO:0071267)2.46535890
141L-methionine biosynthetic process (GO:0071265)2.46535890
142mitochondrial calcium ion homeostasis (GO:0051560)2.46441212
143protein targeting to mitochondrion (GO:0006626)2.45948196
144DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45706851
145nonribosomal peptide biosynthetic process (GO:0019184)2.45338539
146negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.45188630
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45166003
148regulation of B cell apoptotic process (GO:0002902)2.44133802
149acyl-CoA biosynthetic process (GO:0071616)2.44059475
150thioester biosynthetic process (GO:0035384)2.44059475
151response to interferon-beta (GO:0035456)2.42276758
152positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.42092473
153regulation of cilium movement (GO:0003352)2.40110997
154regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.38007545
155deoxyribonucleotide catabolic process (GO:0009264)2.37932068
156regulation of mitochondrial fission (GO:0090140)2.36899457
157purine deoxyribonucleotide metabolic process (GO:0009151)2.36497276
1582-deoxyribonucleotide metabolic process (GO:0009394)2.36422791
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.36331118
160regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.35479982
161negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.35281398
162regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.35046973
163mature B cell differentiation involved in immune response (GO:0002313)2.34717583
164response to pheromone (GO:0019236)2.34362445
165C-terminal protein amino acid modification (GO:0018410)2.33185358
166regulation of hexokinase activity (GO:1903299)2.33170235
167regulation of glucokinase activity (GO:0033131)2.33170235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.66182671
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.27018910
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12534114
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.99579485
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91379629
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78436916
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.55754830
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.54738823
9ZNF274_21170338_ChIP-Seq_K562_Hela2.48227667
10TAF15_26573619_Chip-Seq_HEK293_Human2.42229860
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30233015
12VDR_22108803_ChIP-Seq_LS180_Human2.21966855
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20737242
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.17652569
15GBX2_23144817_ChIP-Seq_PC3_Human2.10492462
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08920286
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08184331
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.06179847
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00684213
20FOXP3_21729870_ChIP-Seq_TREG_Human1.99356953
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91762221
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89122755
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86192422
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74896714
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74855295
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71085496
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71085496
28ER_23166858_ChIP-Seq_MCF-7_Human1.67755196
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67350375
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66863197
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59555643
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56395907
33GATA3_26560356_Chip-Seq_TH2_Human1.55554606
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46828072
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46718385
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46682977
37HTT_18923047_ChIP-ChIP_STHdh_Human1.44744876
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.43294075
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43122735
40* SPI1_23547873_ChIP-Seq_NB4_Human1.40376743
41TP53_22573176_ChIP-Seq_HFKS_Human1.38888152
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38847996
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.38484752
44FUS_26573619_Chip-Seq_HEK293_Human1.37827363
45AR_20517297_ChIP-Seq_VCAP_Human1.36718482
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35219595
47MYB_26560356_Chip-Seq_TH2_Human1.34850404
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.34288075
49ELK1_19687146_ChIP-ChIP_HELA_Human1.32421373
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32076914
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.32076914
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30868013
53IRF1_19129219_ChIP-ChIP_H3396_Human1.29128223
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28603169
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28507682
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28369939
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24328142
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24061882
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21300168
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.19972954
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18614703
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18458429
63CIITA_25753668_ChIP-Seq_RAJI_Human1.17498033
64MYC_18940864_ChIP-ChIP_HL60_Human1.16925189
65* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16685545
66GABP_19822575_ChIP-Seq_HepG2_Human1.16032945
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15322506
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15283471
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15114259
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.14339888
71P300_19829295_ChIP-Seq_ESCs_Human1.13672631
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12454886
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.12094998
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11990075
75GATA3_27048872_Chip-Seq_THYMUS_Human1.11614667
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08535917
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07839022
78CBP_20019798_ChIP-Seq_JUKART_Human1.07839022
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07526441
80SOX2_19829295_ChIP-Seq_ESCs_Human1.05718344
81NANOG_19829295_ChIP-Seq_ESCs_Human1.05718344
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.05694978
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04939715
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.04793116
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04509652
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04281958
87VDR_23849224_ChIP-Seq_CD4+_Human1.04021412
88NCOR_22424771_ChIP-Seq_293T_Human1.03567178
89* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03214300
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.02340209
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02006533
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01085094
93EOMES_21245162_ChIP-Seq_HESCs_Human1.00524056
94* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99982098
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99811849
96JUN_21703547_ChIP-Seq_K562_Human0.98510711
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97964219
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97239241
99ERG_20517297_ChIP-Seq_VCAP_Human0.96841884
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.96478069
101FOXH1_21741376_ChIP-Seq_EPCs_Human0.96454725
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96065727
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96059939
104EWS_26573619_Chip-Seq_HEK293_Human0.95978882
105ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95534476
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95256203
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95098408
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94270107
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93942361
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93913155
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93412126
112IRF8_27001747_Chip-Seq_BMDM_Mouse0.93063490
113TP53_18474530_ChIP-ChIP_U2OS_Human0.92896535
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92749311
115TFEB_21752829_ChIP-Seq_HELA_Human0.92723532
116* CBX2_27304074_Chip-Seq_ESCs_Mouse0.92161878
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92053802
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.90683538
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90614820
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88954961
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.88273551
122* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87230417
123* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87022849
124IGF1R_20145208_ChIP-Seq_DFB_Human0.86815153
125* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85910497
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85862305
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.85781860
128DCP1A_22483619_ChIP-Seq_HELA_Human0.85747274
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.83160629
130* CMYC_18555785_Chip-Seq_ESCs_Mouse0.83070084
131* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82798252
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82794359
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82002584
134* STAT3_18555785_Chip-Seq_ESCs_Mouse0.80793769
135PRDM14_20953172_ChIP-Seq_ESCs_Human0.80455904
136SMAD1_18555785_Chip-Seq_ESCs_Mouse0.79553680
137SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79146945
138* SOX2_18555785_Chip-Seq_ESCs_Mouse0.78087606
139SALL4_22934838_ChIP-ChIP_CD34+_Human0.77174152
140* P300_18555785_Chip-Seq_ESCs_Mouse0.76973624
141* P53_22387025_ChIP-Seq_ESCs_Mouse0.76855238
142* NANOG_18555785_Chip-Seq_ESCs_Mouse0.76727369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.77053717
2MP0003806_abnormal_nucleotide_metabolis3.61299693
3MP0001905_abnormal_dopamine_level3.30653612
4MP0009379_abnormal_foot_pigmentation3.11586555
5MP0001529_abnormal_vocalization2.80214570
6MP0003880_abnormal_central_pattern2.79491052
7MP0003195_calcinosis2.61796900
8MP0003329_amyloid_beta_deposits2.27064652
9MP0003186_abnormal_redox_activity2.20901520
10MP0005645_abnormal_hypothalamus_physiol2.12179584
11MP0005409_darkened_coat_color2.05160475
12MP0008438_abnormal_cutaneous_collagen2.01269093
13MP0004147_increased_porphyrin_level1.98884084
14MP0002876_abnormal_thyroid_physiology1.97873793
15MP0005408_hypopigmentation1.95521487
16MP0004142_abnormal_muscle_tone1.92930060
17MP0000566_synostosis1.88979733
18MP0003950_abnormal_plasma_membrane1.88281047
19MP0000372_irregular_coat_pigmentation1.85136482
20MP0000516_abnormal_urinary_system1.80089913
21MP0005367_renal/urinary_system_phenotyp1.80089913
22MP0005171_absent_coat_pigmentation1.78813586
23MP0006036_abnormal_mitochondrial_physio1.74360876
24MP0001800_abnormal_humoral_immune1.73577771
25MP0002166_altered_tumor_susceptibility1.72912897
26MP0006082_CNS_inflammation1.69864851
27MP0009697_abnormal_copulation1.69607352
28MP0003690_abnormal_glial_cell1.64387818
29MP0005084_abnormal_gallbladder_morpholo1.64343180
30MP0008875_abnormal_xenobiotic_pharmacok1.62653569
31MP0003656_abnormal_erythrocyte_physiolo1.62370046
32MP0002139_abnormal_hepatobiliary_system1.62123374
33MP0003787_abnormal_imprinting1.57548591
34MP0009764_decreased_sensitivity_to1.56752096
35MP0003724_increased_susceptibility_to1.55393636
36MP0003786_premature_aging1.54112742
37MP0002148_abnormal_hypersensitivity_rea1.54030592
38MP0000604_amyloidosis1.53638742
39MP0002102_abnormal_ear_morphology1.52436817
40MP0002295_abnormal_pulmonary_circulatio1.52313026
41MP0005058_abnormal_lysosome_morphology1.51511849
42MP0009785_altered_susceptibility_to1.50173591
43MP0006072_abnormal_retinal_apoptosis1.48844557
44MP0004145_abnormal_muscle_electrophysio1.46881184
45MP0002723_abnormal_immune_serum1.44758996
46MP0001986_abnormal_taste_sensitivity1.42625255
47MP0002452_abnormal_antigen_presenting1.42241540
48MP0005083_abnormal_biliary_tract1.38675132
49MP0004043_abnormal_pH_regulation1.38621870
50MP0001853_heart_inflammation1.37732248
51MP0002272_abnormal_nervous_system1.36045436
52MP0002163_abnormal_gland_morphology1.33056119
53MP0005646_abnormal_pituitary_gland1.32328512
54MP0004381_abnormal_hair_follicle1.30370093
55MP0002420_abnormal_adaptive_immunity1.28567034
56MP0008058_abnormal_DNA_repair1.27751995
57MP0001819_abnormal_immune_cell1.27281399
58MP0003634_abnormal_glial_cell1.25389073
59MP0005451_abnormal_body_composition1.25169569
60MP0009046_muscle_twitch1.23695247
61MP0003136_yellow_coat_color1.21874869
62MP0005464_abnormal_platelet_physiology1.20877543
63MP0005332_abnormal_amino_acid1.20476356
64MP0001542_abnormal_bone_strength1.20001551
65MP0001661_extended_life_span1.18548498
66MP0001346_abnormal_lacrimal_gland1.18021095
67MP0005503_abnormal_tendon_morphology1.17888698
68MP0008877_abnormal_DNA_methylation1.16956569
69MP0010386_abnormal_urinary_bladder1.16616156
70MP0008995_early_reproductive_senescence1.16474670
71MP0001984_abnormal_olfaction1.16253319
72MP0002006_tumorigenesis1.14469501
73MP0005636_abnormal_mineral_homeostasis1.13067803
74MP0005584_abnormal_enzyme/coenzyme_acti1.12401667
75MP0001845_abnormal_inflammatory_respons1.12136344
76MP0002736_abnormal_nociception_after1.11293686
77MP0006035_abnormal_mitochondrial_morpho1.09038204
78MP0002837_dystrophic_cardiac_calcinosis1.08627319
79MP0002933_joint_inflammation1.08482463
80MP0002064_seizures1.08451840
81MP0004134_abnormal_chest_morphology1.08101998
82MP0002277_abnormal_respiratory_mucosa1.07807608
83MP0005253_abnormal_eye_physiology1.06556930
84MP0005397_hematopoietic_system_phenotyp1.05904392
85MP0001545_abnormal_hematopoietic_system1.05904392
86MP0008872_abnormal_physiological_respon1.05775830
87MP0008260_abnormal_autophagy1.05058148
88MP0002138_abnormal_hepatobiliary_system1.04807385
89MP0000689_abnormal_spleen_morphology1.04533232
90MP0004742_abnormal_vestibular_system1.04358356
91MP0003252_abnormal_bile_duct1.04199647
92MP0001188_hyperpigmentation1.03771528
93MP0002229_neurodegeneration1.02641897
94MP0005174_abnormal_tail_pigmentation1.02418330
95MP0005410_abnormal_fertilization1.01649616
96MP0002693_abnormal_pancreas_physiology1.01246147
97MP0005551_abnormal_eye_electrophysiolog1.01094119
98MP0005671_abnormal_response_to1.00677982
99MP0005379_endocrine/exocrine_gland_phen0.99822067
100MP0000013_abnormal_adipose_tissue0.96812652
101MP0002822_catalepsy0.96718127
102MP0005000_abnormal_immune_tolerance0.96115455
103MP0000465_gastrointestinal_hemorrhage0.95729804
104MP0000716_abnormal_immune_system0.94401821
105MP0002938_white_spotting0.93879789
106MP0005365_abnormal_bile_salt0.93620685
107MP0003436_decreased_susceptibility_to0.93456984
108MP0010155_abnormal_intestine_physiology0.93308549
109MP0005389_reproductive_system_phenotype0.91371028
110MP0001835_abnormal_antigen_presentation0.90275546
111MP0003866_abnormal_defecation0.89988654
112MP0001873_stomach_inflammation0.89344068
113MP0000569_abnormal_digit_pigmentation0.88603285
114MP0002419_abnormal_innate_immunity0.88479210
115MP0002405_respiratory_system_inflammati0.88474364
116MP0001764_abnormal_homeostasis0.88412898
117MP0009333_abnormal_splenocyte_physiolog0.87967404
118MP0002398_abnormal_bone_marrow0.87708985
119MP0006276_abnormal_autonomic_nervous0.87413216
120MP0003011_delayed_dark_adaptation0.87368678
121MP0009384_cardiac_valve_regurgitation0.87268340
122MP0005535_abnormal_body_temperature0.87235772
123MP0005025_abnormal_response_to0.87207621
124MP0005085_abnormal_gallbladder_physiolo0.87084742
125MP0004270_analgesia0.86974294
126MP0003763_abnormal_thymus_physiology0.86368860
127MP0004036_abnormal_muscle_relaxation0.86298790
128MP0009745_abnormal_behavioral_response0.84999346
129MP0000685_abnormal_immune_system0.84251131
130MP0001919_abnormal_reproductive_system0.83516290
131MP0005360_urolithiasis0.83497495
132MP0001756_abnormal_urination0.82418938
133MP0000681_abnormal_thyroid_gland0.81814468
134MP0000343_altered_response_to0.80528180
135MP0002734_abnormal_mechanical_nocicepti0.79956256
136MP0002095_abnormal_skin_pigmentation0.79840343
137MP0001348_abnormal_lacrimal_gland0.79812354
138MP0005075_abnormal_melanosome_morpholog0.78990944
139MP0005164_abnormal_response_to0.78469794
140MP0001666_abnormal_nutrient_absorption0.78200199
141MP0003632_abnormal_nervous_system0.77551892
142MP0002638_abnormal_pupillary_reflex0.76025333
143MP0000749_muscle_degeneration0.74989597
144MP0001790_abnormal_immune_system0.72801061
145MP0005387_immune_system_phenotype0.72801061
146MP0001664_abnormal_digestion0.71922367
147MP0000015_abnormal_ear_pigmentation0.71203435
148MP0001851_eye_inflammation0.70454322
149MP0000230_abnormal_systemic_arterial0.70253189
150MP0001485_abnormal_pinna_reflex0.70050570
151MP0001970_abnormal_pain_threshold0.69935659
152MP0008469_abnormal_protein_level0.67241643
153MP0001486_abnormal_startle_reflex0.67156552

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.77134753
2Abnormal mitochondria in muscle tissue (HP:0008316)5.22555617
3Mitochondrial inheritance (HP:0001427)5.02535108
4Acute encephalopathy (HP:0006846)4.86308376
5Increased serum pyruvate (HP:0003542)4.72146907
6Abnormality of glycolysis (HP:0004366)4.72146907
7Progressive macrocephaly (HP:0004481)4.70982376
8Hepatocellular necrosis (HP:0001404)4.65761260
9Hepatic necrosis (HP:0002605)4.30510250
10Increased CSF lactate (HP:0002490)4.27724618
11Renal Fanconi syndrome (HP:0001994)4.14147122
12Parakeratosis (HP:0001036)4.11440258
133-Methylglutaconic aciduria (HP:0003535)4.11156641
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.70454770
15Cerebral edema (HP:0002181)3.60577551
16Increased hepatocellular lipid droplets (HP:0006565)3.58634040
17Neurofibrillary tangles (HP:0002185)3.55765308
18Leukodystrophy (HP:0002415)3.55467632
19Lipid accumulation in hepatocytes (HP:0006561)3.41080989
20Respiratory failure (HP:0002878)3.20115310
21Elevated erythrocyte sedimentation rate (HP:0003565)3.11495317
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95590545
23Lactic acidosis (HP:0003128)2.92560833
24Optic disc pallor (HP:0000543)2.88237459
25Increased intramyocellular lipid droplets (HP:0012240)2.87891083
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80999896
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.79297774
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.79297774
29Hyperventilation (HP:0002883)2.78212020
30Methylmalonic acidemia (HP:0002912)2.76564863
31Thyroiditis (HP:0100646)2.75544598
32Abnormality of renal resorption (HP:0011038)2.73781530
33Congenital ichthyosiform erythroderma (HP:0007431)2.70917908
34Abnormality of the prostate (HP:0008775)2.66624328
35Sensory axonal neuropathy (HP:0003390)2.66308119
36Molar tooth sign on MRI (HP:0002419)2.66216683
37Abnormality of midbrain morphology (HP:0002418)2.66216683
38Increased serum lactate (HP:0002151)2.63940443
39Exercise intolerance (HP:0003546)2.61870580
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61212821
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61212821
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60557710
43Cerebral hemorrhage (HP:0001342)2.60133527
44Severe combined immunodeficiency (HP:0004430)2.59346246
45Retinal dysplasia (HP:0007973)2.58302417
46Increased muscle lipid content (HP:0009058)2.58293405
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56964645
48Neuroendocrine neoplasm (HP:0100634)2.55170017
49Stomatitis (HP:0010280)2.54394399
50Vacuolated lymphocytes (HP:0001922)2.51545204
51Abnormality of B cell number (HP:0010975)2.51526073
52Exertional dyspnea (HP:0002875)2.49078309
53Hypoproteinemia (HP:0003075)2.43328127
54Renal cortical cysts (HP:0000803)2.42215997
55Methylmalonic aciduria (HP:0012120)2.33386706
56Abnormal rod and cone electroretinograms (HP:0008323)2.32228962
57Ketoacidosis (HP:0001993)2.32151515
58Panhypogammaglobulinemia (HP:0003139)2.32098707
59Abnormal gallbladder physiology (HP:0012438)2.29820826
60Cholecystitis (HP:0001082)2.29820826
61B lymphocytopenia (HP:0010976)2.28984957
62Cerebral inclusion bodies (HP:0100314)2.27357013
63X-linked dominant inheritance (HP:0001423)2.25539528
64Glycosuria (HP:0003076)2.23353602
65Abnormality of urine glucose concentration (HP:0011016)2.23353602
66Hypothermia (HP:0002045)2.22402560
67Pancreatic cysts (HP:0001737)2.19388867
68CNS demyelination (HP:0007305)2.18142061
69Spastic paraparesis (HP:0002313)2.16697088
70Hepatosplenomegaly (HP:0001433)2.15943873
71Pheochromocytoma (HP:0002666)2.14503516
72Aplastic anemia (HP:0001915)2.14266201
73Steatorrhea (HP:0002570)2.12739620
74Generalized aminoaciduria (HP:0002909)2.09550867
75Progressive microcephaly (HP:0000253)2.08444259
76Lethargy (HP:0001254)2.08188477
77Patchy hypopigmentation of hair (HP:0011365)2.08103439
78IgG deficiency (HP:0004315)2.07943274
79Congenital primary aphakia (HP:0007707)2.06046434
80Constricted visual fields (HP:0001133)2.03967010
81Gait imbalance (HP:0002141)2.03467584
82Abolished electroretinogram (ERG) (HP:0000550)2.01170536
83Nephronophthisis (HP:0000090)1.98575716
84Respiratory difficulties (HP:0002880)1.97778467
85Cerebral hypomyelination (HP:0006808)1.97313198
86Abnormality of the renal cortex (HP:0011035)1.96675701
87Nephrogenic diabetes insipidus (HP:0009806)1.96294228
88Ketosis (HP:0001946)1.93131304
89Abnormality of fatty-acid metabolism (HP:0004359)1.93053272
90Agammaglobulinemia (HP:0004432)1.92792658
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92120436
92Abnormality of magnesium homeostasis (HP:0004921)1.91184172
93Chronic mucocutaneous candidiasis (HP:0002728)1.89931997
94Recurrent cutaneous fungal infections (HP:0011370)1.89931997
95Dicarboxylic aciduria (HP:0003215)1.89800259
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89800259
97Autoamputation (HP:0001218)1.89574295
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.89231710
99Hyperphosphaturia (HP:0003109)1.87101390
100Hypobetalipoproteinemia (HP:0003563)1.86994162
101Chronic diarrhea (HP:0002028)1.84991704
102Congenital stationary night blindness (HP:0007642)1.84901162
103Pulmonary fibrosis (HP:0002206)1.83450812
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83203370
105Vomiting (HP:0002013)1.81580318
106Combined immunodeficiency (HP:0005387)1.80476907
107Attenuation of retinal blood vessels (HP:0007843)1.77603837
108Purpura (HP:0000979)1.76846880
109Abnormality of T cell physiology (HP:0011840)1.76328665
110Abnormality of vitamin B metabolism (HP:0004340)1.76298528
111Stridor (HP:0010307)1.76295549
112Neutropenia (HP:0001875)1.76123320
113Hypoplasia of the uterus (HP:0000013)1.75570829
114True hermaphroditism (HP:0010459)1.75380514
115Medial flaring of the eyebrow (HP:0010747)1.74837379
116Pancreatic fibrosis (HP:0100732)1.73878793
117Recurrent fungal infections (HP:0002841)1.73553990
118Abnormality of placental membranes (HP:0011409)1.72748003
119Amniotic constriction ring (HP:0009775)1.72748003
120Type I transferrin isoform profile (HP:0003642)1.69911414
121Akinesia (HP:0002304)1.68143150
122Fat malabsorption (HP:0002630)1.66992282
123Obstructive lung disease (HP:0006536)1.66442210
124Chronic obstructive pulmonary disease (HP:0006510)1.66442210
125Infantile muscular hypotonia (HP:0008947)1.66073956
126Type 2 muscle fiber atrophy (HP:0003554)1.65961340
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65526982
128Abnormality of alanine metabolism (HP:0010916)1.65526982
129Hyperalaninemia (HP:0003348)1.65526982
130Large for gestational age (HP:0001520)1.65142443
131Decreased central vision (HP:0007663)1.64318884
132Renal tubular dysfunction (HP:0000124)1.64044762
133Aplasia/hypoplasia of the uterus (HP:0008684)1.63787736
134Cerebral palsy (HP:0100021)1.63625007
135Abnormality of methionine metabolism (HP:0010901)1.61458502
136Microvesicular hepatic steatosis (HP:0001414)1.61190592
137Abnormal pupillary function (HP:0007686)1.60519141
138White forelock (HP:0002211)1.60387818
139Hypoplastic pelvis (HP:0008839)1.59882044
140Metaphyseal dysplasia (HP:0100255)1.59779808
141Emotional lability (HP:0000712)1.59486055
142Split foot (HP:0001839)1.57588716
143Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.57168151
144Abnormal urine phosphate concentration (HP:0012599)1.55762454
145Erythroderma (HP:0001019)1.55538731
146Abnormal glycosylation (HP:0012345)1.55485351
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.55485351
148Abnormal protein N-linked glycosylation (HP:0012347)1.55485351
149Abnormal protein glycosylation (HP:0012346)1.55485351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.94987566
2FRK3.57457121
3PBK3.52603564
4OXSR13.31241194
5TAOK33.16821376
6MST43.09706083
7MAP4K22.85405278
8BCR2.84641452
9STK162.61800558
10TNIK2.61477767
11CDK192.50980606
12TESK22.50254184
13LIMK12.28498565
14NME12.20478400
15ERBB32.15789206
16MAP3K122.06823936
17CASK2.02839506
18TRIM281.97266234
19ARAF1.91675489
20WNK41.89904881
21NME21.82808475
22MAPKAPK51.78960945
23BMPR1B1.77603311
24NUAK11.76895091
25CSNK1G31.74435416
26BCKDK1.69240142
27MUSK1.58059423
28PINK11.55829844
29EPHB11.55510379
30PIM21.52404462
31MET1.43037665
32MAP2K71.38503414
33ITK1.37071790
34EIF2AK31.36207926
35MYLK1.35152478
36GRK11.32937272
37CSNK1A1L1.31806254
38CCNB11.31802302
39CDK81.28602583
40VRK21.27220435
41BMPR21.23677389
42CSNK1G11.21994084
43PKN11.21740154
44MAP3K41.20448243
45ABL21.19459980
46FGR1.19270603
47FLT31.18788752
48BUB11.17966973
49CSNK1G21.14909500
50TLK11.12759361
51GRK71.08054665
52CAMK2B1.07136484
53DYRK21.06249816
54INSRR1.05826489
55DAPK11.04775910
56ADRBK20.94334873
57IRAK40.91130067
58CAMK2D0.91019394
59RPS6KA40.89900505
60ROCK20.87315741
61MAP4K10.85505267
62TRPM70.84897914
63SIK30.83340228
64KIT0.82429904
65EIF2AK10.82019541
66PRKCQ0.80401149
67SCYL20.79245958
68MAP2K60.77707348
69WNK30.77401026
70VRK10.76058409
71PLK20.76025887
72CAMK2G0.74830595
73MAPK130.74806202
74MINK10.73808087
75PRKCE0.72969876
76TESK10.72621537
77NEK60.69756113
78EPHA40.69073862
79PDK20.68896767
80PIK3CA0.68778535
81CAMK2A0.68745274
82BTK0.68226098
83PIK3CG0.67020080
84ERBB40.63181511
85MOS0.62251630
86DAPK20.61709095
87MAP3K140.61130080
88WNK10.59972639
89GRK60.58850276
90GRK50.58825336
91TXK0.58685971
92KDR0.58082843
93ABL10.57748184
94RPS6KA50.57195758
95UHMK10.56566465
96IRAK20.56490413
97TBK10.56127824
98CDK140.56009896
99ADRBK10.54096801
100SRPK10.53828818
101MST1R0.52486576
102DAPK30.52410674
103BRAF0.51650372
104FGFR20.51206135
105MAPKAPK30.49233127
106PRPF4B0.48976194
107IGF1R0.48223423
108LYN0.46803020
109PAK30.46678128
110IRAK10.46142114
111OBSCN0.45272671
112TYK20.45254444
113PTK2B0.44864366
114FES0.44462113
115BLK0.44196198
116MAP3K50.44131462
117TEC0.43451110
118CSF1R0.41799072
119IKBKE0.41268756
120CDK180.40194630
121SYK0.40050150
122ZAK0.39504433
123MATK0.39467288
124PHKG20.38821522
125PHKG10.38821522
126CDK150.38474397
127ACVR1B0.38179766
128NTRK10.37840560
129CDK11A0.36871945
130PRKCD0.36248534
131LCK0.36075849
132IKBKB0.35897568
133ILK0.35288232
134MAPK150.34505952
135CAMKK20.34369479
136EIF2AK20.33958495

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.01220217
2Parkinsons disease_Homo sapiens_hsa050124.00611005
3Protein export_Homo sapiens_hsa030603.99617796
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.30099596
5Proteasome_Homo sapiens_hsa030503.23072290
6Alzheimers disease_Homo sapiens_hsa050103.15512292
7Fatty acid elongation_Homo sapiens_hsa000623.09301518
8Steroid biosynthesis_Homo sapiens_hsa001002.95940632
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95188636
10Type I diabetes mellitus_Homo sapiens_hsa049402.91361457
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.68546433
12Huntingtons disease_Homo sapiens_hsa050162.50034823
13Sulfur metabolism_Homo sapiens_hsa009202.25741941
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17654944
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98352973
16Collecting duct acid secretion_Homo sapiens_hsa049661.93132656
17Ribosome_Homo sapiens_hsa030101.80675229
18Antigen processing and presentation_Homo sapiens_hsa046121.58096703
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56865026
20Peroxisome_Homo sapiens_hsa041461.53114951
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47550325
22Rheumatoid arthritis_Homo sapiens_hsa053231.46734250
23Ether lipid metabolism_Homo sapiens_hsa005651.45061805
24Vibrio cholerae infection_Homo sapiens_hsa051101.43804156
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.43663135
26Folate biosynthesis_Homo sapiens_hsa007901.38965965
27Propanoate metabolism_Homo sapiens_hsa006401.38655904
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35565798
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35009273
30Glutathione metabolism_Homo sapiens_hsa004801.34908233
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31457491
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27730748
33Cardiac muscle contraction_Homo sapiens_hsa042601.22900192
34Staphylococcus aureus infection_Homo sapiens_hsa051501.22321053
35Phototransduction_Homo sapiens_hsa047441.21719381
36Viral myocarditis_Homo sapiens_hsa054161.21292584
37Pyruvate metabolism_Homo sapiens_hsa006201.19915404
38Histidine metabolism_Homo sapiens_hsa003401.19577637
39Butanoate metabolism_Homo sapiens_hsa006501.16907457
40RNA polymerase_Homo sapiens_hsa030201.13834978
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13603078
42Sphingolipid metabolism_Homo sapiens_hsa006001.11870779
43Chemical carcinogenesis_Homo sapiens_hsa052041.08994766
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03737083
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01007350
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94103660
47Phagosome_Homo sapiens_hsa041450.93613136
48RNA degradation_Homo sapiens_hsa030180.91042868
49Metabolic pathways_Homo sapiens_hsa011000.90200020
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87714018
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.87416153
52Leishmaniasis_Homo sapiens_hsa051400.86698304
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.84683250
54Autoimmune thyroid disease_Homo sapiens_hsa053200.82015119
55Arginine and proline metabolism_Homo sapiens_hsa003300.81960416
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81495870
57Allograft rejection_Homo sapiens_hsa053300.79210050
58Homologous recombination_Homo sapiens_hsa034400.78452475
59Tyrosine metabolism_Homo sapiens_hsa003500.77724062
60Arachidonic acid metabolism_Homo sapiens_hsa005900.76731438
61Linoleic acid metabolism_Homo sapiens_hsa005910.75370713
62Fatty acid metabolism_Homo sapiens_hsa012120.74159769
63Graft-versus-host disease_Homo sapiens_hsa053320.71588436
64Fatty acid degradation_Homo sapiens_hsa000710.71396872
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70912013
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70623926
67Other glycan degradation_Homo sapiens_hsa005110.67146411
68Retinol metabolism_Homo sapiens_hsa008300.66582861
69Malaria_Homo sapiens_hsa051440.64459407
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63976370
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62730537
72Fanconi anemia pathway_Homo sapiens_hsa034600.62403980
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59998623
74Legionellosis_Homo sapiens_hsa051340.59544745
75Base excision repair_Homo sapiens_hsa034100.56947904
76Systemic lupus erythematosus_Homo sapiens_hsa053220.55539648
77Sulfur relay system_Homo sapiens_hsa041220.54970262
78Lysosome_Homo sapiens_hsa041420.54609458
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54492893
80Regulation of autophagy_Homo sapiens_hsa041400.52704639
81Nitrogen metabolism_Homo sapiens_hsa009100.52327181
82Tuberculosis_Homo sapiens_hsa051520.50785257
83Serotonergic synapse_Homo sapiens_hsa047260.49391328
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47525918
85Herpes simplex infection_Homo sapiens_hsa051680.46741169
86Pyrimidine metabolism_Homo sapiens_hsa002400.43845388
87Carbon metabolism_Homo sapiens_hsa012000.43021835
88Phenylalanine metabolism_Homo sapiens_hsa003600.43015769
89beta-Alanine metabolism_Homo sapiens_hsa004100.42535911
90Vitamin digestion and absorption_Homo sapiens_hsa049770.42027388
91Basal transcription factors_Homo sapiens_hsa030220.41687167
92Shigellosis_Homo sapiens_hsa051310.40871630
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38615097
94Tryptophan metabolism_Homo sapiens_hsa003800.38613142
95Asthma_Homo sapiens_hsa053100.38426396
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35604344
97Salmonella infection_Homo sapiens_hsa051320.35580651
98Caffeine metabolism_Homo sapiens_hsa002320.35091581
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.31858075
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31414722
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31149665
102Pentose phosphate pathway_Homo sapiens_hsa000300.30012723
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.29764533
104Purine metabolism_Homo sapiens_hsa002300.28779439
105Salivary secretion_Homo sapiens_hsa049700.28101593
106Epstein-Barr virus infection_Homo sapiens_hsa051690.28081036
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.27799491
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27439300
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25932782
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25766225
111Pertussis_Homo sapiens_hsa051330.25475656
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25315437
113Complement and coagulation cascades_Homo sapiens_hsa046100.24323124
114N-Glycan biosynthesis_Homo sapiens_hsa005100.23590161
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23416977
116Synaptic vesicle cycle_Homo sapiens_hsa047210.19122195
117African trypanosomiasis_Homo sapiens_hsa051430.13908805
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.13517228
119Primary immunodeficiency_Homo sapiens_hsa053400.13416880
120Hematopoietic cell lineage_Homo sapiens_hsa046400.13027935
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12710457
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12377897
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11252775
124Non-homologous end-joining_Homo sapiens_hsa034500.11145072
125Nucleotide excision repair_Homo sapiens_hsa034200.10535849
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.07018890

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