COL4A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)8.84779316
2artery development (GO:0060840)7.10505863
3regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.52737166
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.47759738
5prostate gland epithelium morphogenesis (GO:0060740)5.94969596
6lateral sprouting from an epithelium (GO:0060601)5.94815179
7hemidesmosome assembly (GO:0031581)5.71211362
8epithelial cell differentiation involved in prostate gland development (GO:0060742)5.42788530
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.80459114
10mitotic cell cycle arrest (GO:0071850)4.75519547
11COPI coating of Golgi vesicle (GO:0048205)4.73196419
12Golgi transport vesicle coating (GO:0048200)4.73196419
13limb bud formation (GO:0060174)4.54525968
14positive regulation of steroid hormone secretion (GO:2000833)4.53753932
15regulation of receptor binding (GO:1900120)4.45611691
16notochord development (GO:0030903)4.45333052
17fucose catabolic process (GO:0019317)4.40825294
18L-fucose metabolic process (GO:0042354)4.40825294
19L-fucose catabolic process (GO:0042355)4.40825294
20mannose metabolic process (GO:0006013)4.27406527
21regulation of cardioblast differentiation (GO:0051890)4.18601654
22axon extension involved in axon guidance (GO:0048846)4.10081607
23neuron projection extension involved in neuron projection guidance (GO:1902284)4.10081607
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.08875123
25otic vesicle formation (GO:0030916)4.08660240
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.03804865
27tongue development (GO:0043586)3.95518862
28lung secretory cell differentiation (GO:0061140)3.95119894
29convergent extension (GO:0060026)3.93516648
30ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.91563147
31positive regulation of catenin import into nucleus (GO:0035413)3.90424700
32positive regulation of nuclease activity (GO:0032075)3.89529166
33G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.88213209
34radial glial cell differentiation (GO:0060019)3.86457294
35desmosome organization (GO:0002934)3.85343301
36apoptotic cell clearance (GO:0043277)3.84004307
37response to testosterone (GO:0033574)3.82733221
38regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.76271131
39regulation of non-canonical Wnt signaling pathway (GO:2000050)3.74933215
40protein retention in ER lumen (GO:0006621)3.68242264
41lens fiber cell development (GO:0070307)3.64694573
42epithelial cell maturation (GO:0002070)3.64303132
43activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.63552991
44galactose catabolic process (GO:0019388)3.62740624
45lung-associated mesenchyme development (GO:0060484)3.61276299
46pharyngeal system development (GO:0060037)3.60586708
47embryonic camera-type eye development (GO:0031076)3.60363229
48insulin-like growth factor receptor signaling pathway (GO:0048009)3.53500060
49cell proliferation in forebrain (GO:0021846)3.50722744
50endoplasmic reticulum unfolded protein response (GO:0030968)3.50665612
51mesenchymal cell proliferation (GO:0010463)3.50224918
52regulation of nuclease activity (GO:0032069)3.48474190
53neuronal stem cell maintenance (GO:0097150)3.46651791
54regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.44852508
55somite development (GO:0061053)3.44712708
56midbrain development (GO:0030901)3.41753716
57cellular response to unfolded protein (GO:0034620)3.37432361
58establishment of tissue polarity (GO:0007164)3.35231162
59establishment of planar polarity (GO:0001736)3.35231162
60dorsal/ventral axis specification (GO:0009950)3.34822582
61positive regulation of gastrulation (GO:2000543)3.33869234
62Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31643871
63positive regulation of natural killer cell differentiation (GO:0032825)3.30720048
64non-canonical Wnt signaling pathway (GO:0035567)3.30138012
65fucose metabolic process (GO:0006004)3.29032279
66regulation of establishment of planar polarity (GO:0090175)3.28216714
67valine metabolic process (GO:0006573)3.26523184
68epithelial cell-cell adhesion (GO:0090136)3.25027811
69ER-nucleus signaling pathway (GO:0006984)3.23038853
70intestinal epithelial cell development (GO:0060576)3.22864172
71N-glycan processing (GO:0006491)3.21788105
72axis elongation (GO:0003401)3.20701428
73embryonic foregut morphogenesis (GO:0048617)3.18320355
74negative regulation of axon guidance (GO:1902668)3.15009847
75hippo signaling (GO:0035329)3.12287471
76cell surface receptor signaling pathway involved in heart development (GO:0061311)3.11229874
77positive regulation of neuroblast proliferation (GO:0002052)3.09460028
78camera-type eye morphogenesis (GO:0048593)3.08856373
79kidney morphogenesis (GO:0060993)3.06288931
80cellular response to topologically incorrect protein (GO:0035967)3.05407479
81negative regulation of cell fate specification (GO:0009996)3.02417902
82cell-substrate junction assembly (GO:0007044)3.00867657
83response to endoplasmic reticulum stress (GO:0034976)3.00267560
84potassium ion homeostasis (GO:0055075)2.99313247
85regulation of catenin import into nucleus (GO:0035412)2.98903495
86retinal ganglion cell axon guidance (GO:0031290)2.98636483
87neuron fate determination (GO:0048664)2.98016438
88mesenchyme morphogenesis (GO:0072132)2.97926811
89hormone catabolic process (GO:0042447)2.97375530
90post-anal tail morphogenesis (GO:0036342)2.96883435
91glomerular basement membrane development (GO:0032836)2.96736557
92cranial suture morphogenesis (GO:0060363)2.96379268
93branching involved in salivary gland morphogenesis (GO:0060445)2.95321387
94regulation of cell fate specification (GO:0042659)2.94650196
95regulation of steroid hormone secretion (GO:2000831)2.93062131
96heterochromatin organization (GO:0070828)2.93043504
97mesenchymal-epithelial cell signaling (GO:0060638)2.90044761
98craniofacial suture morphogenesis (GO:0097094)2.88729911
99lens development in camera-type eye (GO:0002088)2.87344253
100atrial septum morphogenesis (GO:0060413)2.86231500
101negative regulation of chondrocyte differentiation (GO:0032331)2.85760566
102presynaptic membrane assembly (GO:0097105)2.84834740
103digestive tract morphogenesis (GO:0048546)2.84761734
104hypotonic response (GO:0006971)2.84383816
105negative regulation of epidermis development (GO:0045683)2.82973156
106glandular epithelial cell differentiation (GO:0002067)2.82661710
107negative regulation of keratinocyte proliferation (GO:0010839)2.82649332
108mammary gland alveolus development (GO:0060749)2.82414236
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.80994651
110DNA unwinding involved in DNA replication (GO:0006268)2.79131504
111embryonic digestive tract morphogenesis (GO:0048557)2.78096632
112regulation of posttranscriptional gene silencing (GO:0060147)2.77312573
113regulation of gene silencing by miRNA (GO:0060964)2.77312573
114regulation of gene silencing by RNA (GO:0060966)2.77312573
115regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.76138097
116negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.76082331
117mesenchymal cell differentiation (GO:0048762)2.75800012
118UDP-N-acetylglucosamine metabolic process (GO:0006047)2.75459628
119cornea development in camera-type eye (GO:0061303)2.75280349
120lung cell differentiation (GO:0060479)2.72744651
121positive regulation of growth hormone secretion (GO:0060124)2.71852455
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71735912
123regulation of mesoderm development (GO:2000380)2.70907161
124lung lobe morphogenesis (GO:0060463)2.70883423
125positive regulation of canonical Wnt signaling pathway (GO:0090263)2.69434161
126metanephros development (GO:0001656)2.68704583
127negative chemotaxis (GO:0050919)2.68404878
128negative regulation of axon extension involved in axon guidance (GO:0048843)2.68360246
129negative regulation of striated muscle cell apoptotic process (GO:0010664)2.66859539
130establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.66481179
131response to unfolded protein (GO:0006986)2.64530996
132thalamus development (GO:0021794)2.64404166
133protein kinase B signaling (GO:0043491)2.64014159
134intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.63519626
135paraxial mesoderm development (GO:0048339)2.62837883
136regulation of growth hormone secretion (GO:0060123)2.61949083
137regulation of polysaccharide biosynthetic process (GO:0032885)2.61943182
138organ growth (GO:0035265)2.61269622
139cellular response to interferon-alpha (GO:0035457)2.60551124
140COPII vesicle coating (GO:0048208)2.60036315
141lung epithelial cell differentiation (GO:0060487)2.59106532
142regulation of hair follicle development (GO:0051797)2.58762530
143cell adhesion mediated by integrin (GO:0033627)2.56502018
144renal system development (GO:0072001)2.55947585
145genitalia morphogenesis (GO:0035112)2.55066608
146anterior/posterior axis specification, embryo (GO:0008595)2.54426565
147canonical Wnt signaling pathway (GO:0060070)2.54043787
148establishment of apical/basal cell polarity (GO:0035089)2.53876095
149positive regulation of glycogen biosynthetic process (GO:0045725)2.53755296
150* multicellular organismal macromolecule metabolic process (GO:0044259)2.53645852
151extracellular matrix assembly (GO:0085029)2.53502383
152peptide cross-linking (GO:0018149)2.53055741
153nonmotile primary cilium assembly (GO:0035058)2.52984078
154gap junction assembly (GO:0016264)2.52548536
155regulation of smoothened signaling pathway (GO:0008589)2.52472236
156negative regulation of smoothened signaling pathway (GO:0045879)2.52432663
157positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.52083044
158somatic stem cell division (GO:0048103)2.51553982
159establishment of nucleus localization (GO:0040023)2.49762333
160apical protein localization (GO:0045176)2.49608337
161bundle of His cell to Purkinje myocyte communication (GO:0086069)2.48783687
162maturation of SSU-rRNA (GO:0030490)2.48467323
163positive regulation of embryonic development (GO:0040019)2.48456168
164positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.47510375
165* multicellular organismal catabolic process (GO:0044243)2.47507788
166midgut development (GO:0007494)2.47074918
167planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46748678
168adult heart development (GO:0007512)2.46481072
169* collagen metabolic process (GO:0032963)2.46470006
170positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.46297062
171regulation of hippo signaling (GO:0035330)2.46124007
172regulation of neuroblast proliferation (GO:1902692)2.45887182
173regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.44567513
174peptide catabolic process (GO:0043171)2.44375350
175* collagen catabolic process (GO:0030574)2.44364586
176pituitary gland development (GO:0021983)2.44307600
177embryonic heart tube morphogenesis (GO:0003143)2.43885801
178polarized epithelial cell differentiation (GO:0030859)2.42890805
179response to topologically incorrect protein (GO:0035966)2.42674496
180body morphogenesis (GO:0010171)2.42537098
181postsynaptic membrane organization (GO:0001941)2.41728688
182cell migration involved in sprouting angiogenesis (GO:0002042)2.41014043
183pre-miRNA processing (GO:0031054)2.40849014
184branch elongation of an epithelium (GO:0060602)2.40805782
185endocardial cushion development (GO:0003197)2.39048029
186regulation of transforming growth factor beta2 production (GO:0032909)2.38664489
187* multicellular organismal metabolic process (GO:0044236)2.37549860
188peptidyl-asparagine modification (GO:0018196)2.37354275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.47431520
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.40565669
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.34207441
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.47199235
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42656573
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.34442836
7E2F7_22180533_ChIP-Seq_HELA_Human3.17827269
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.93116476
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.89652069
10CLOCK_20551151_ChIP-Seq_293T_Human2.83530423
11EZH2_22144423_ChIP-Seq_EOC_Human2.71028498
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.68440743
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.60509725
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55873776
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55694250
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55181705
17ZNF263_19887448_ChIP-Seq_K562_Human2.54559498
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49203513
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.47359763
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.30720827
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21947508
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.21414036
23SOX9_24532713_ChIP-Seq_HFSC_Mouse2.20870266
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.19895588
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.19895588
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.13830659
27SOX2_27498859_Chip-Seq_STOMACH_Mouse2.05448921
28AHR_22903824_ChIP-Seq_MCF-7_Human2.00343108
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.99623008
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98056208
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95137439
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94605675
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.92689420
34SOX2_20726797_ChIP-Seq_SW620_Human1.92660746
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92494749
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92248730
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.90632822
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88399166
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.87660040
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81705211
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.77155187
42FUS_26573619_Chip-Seq_HEK293_Human1.73990707
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71696327
44* CJUN_26792858_Chip-Seq_BT549_Human1.70908318
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.70734645
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68623365
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67590149
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67258393
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66659124
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.66466203
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66107196
52* NANOG_16153702_ChIP-ChIP_HESCs_Human1.65709104
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65476141
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64638676
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.62802121
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61128203
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60329880
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60329880
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58285210
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.55146989
61TAF15_26573619_Chip-Seq_HEK293_Human1.53498638
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.51762948
63RNF2_27304074_Chip-Seq_NSC_Mouse1.51603412
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50778336
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.50703342
66AR_21909140_ChIP-Seq_LNCAP_Human1.50606917
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.50244590
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46997706
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45026580
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44436189
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44436189
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44436189
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44056089
74* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43983524
75* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.42867433
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41180792
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.40481174
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40090098
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38710719
80TP53_16413492_ChIP-PET_HCT116_Human1.38649039
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.38184755
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36260568
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36062869
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.35561243
85GATA6_25053715_ChIP-Seq_YYC3_Human1.33627500
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33100072
87RACK7_27058665_Chip-Seq_MCF-7_Human1.31762282
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30784520
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30610287
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.30447712
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.30447712
92* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.29810586
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.29413113
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28550976
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28415199
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28392876
97TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27907519
98EWS_26573619_Chip-Seq_HEK293_Human1.27355232
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.27239796
100CHD1_26751641_Chip-Seq_LNCaP_Human1.26585363
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.25413273
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25342792
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.24737307
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24607111
105GATA4_25053715_ChIP-Seq_YYC3_Human1.24478416
106ATF3_27146783_Chip-Seq_COLON_Human1.23850705
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23147785
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23147785
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22953191
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21605883
111KLF5_25053715_ChIP-Seq_YYC3_Human1.21453637
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.21179495
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20921072
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.20757140
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.19316710
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19268910
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19084468
118TP53_22127205_ChIP-Seq_IMR90_Human1.18977619
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18660580
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17981312
121P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17960202
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17943393
123BRD4_25478319_ChIP-Seq_HGPS_Human1.16673028
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16171583
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15743324
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15740482
127SOX9_26525672_Chip-Seq_HEART_Mouse1.14899297
128* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14722421
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13084888
130WT1_19549856_ChIP-ChIP_CCG9911_Human1.12570230
131FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12418078
132JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12404466
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11933705
134SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11840257
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11303232
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10464522
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10356614
138CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10048357
139P300_19829295_ChIP-Seq_ESCs_Human1.09834359
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09762150
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09618943
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09585482
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08924084
144FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08881947
145FOXA2_19822575_ChIP-Seq_HepG2_Human1.06207104
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04251710
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03769082
148TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03363813
149PIAS1_25552417_ChIP-Seq_VCAP_Human1.02493166
150NANOG_21062744_ChIP-ChIP_HESCs_Human1.02403012
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01693455
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01683282
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01683282
154WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01630270
155ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01509509
156TP53_18474530_ChIP-ChIP_U2OS_Human1.00492979
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00197646
158NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99145769
159TP63_23658742_ChIP-Seq_EP156T_Human0.98992508
160CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98591041
161* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97278419
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97043006
163CREB1_26743006_Chip-Seq_LNCaP_Human0.95508141
164PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95084181
165TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94907484
166ZNF274_21170338_ChIP-Seq_K562_Hela0.94861987
167LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94171731
168SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94120439
169P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93304322
170CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93122602
171OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92615248
172PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92556652
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.91706209
174ELK3_25401928_ChIP-Seq_HUVEC_Human0.91054444
175FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91041802
176JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90697514
177KDM2B_26808549_Chip-Seq_K562_Human0.89136601
178TCF4_18268006_ChIP-ChIP_LS174T_Human0.88288073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.23801403
2MP0003300_gastrointestinal_ulcer3.48807081
3MP0006292_abnormal_olfactory_placode3.45778718
4MP0000537_abnormal_urethra_morphology3.37887354
5MP0008438_abnormal_cutaneous_collagen3.15087344
6MP0002166_altered_tumor_susceptibility2.98687170
7MP0003705_abnormal_hypodermis_morpholog2.75981658
8MP0005275_abnormal_skin_tensile2.74048939
9MP0002938_white_spotting2.64778440
10MP0004272_abnormal_basement_membrane2.62297280
11MP0005248_abnormal_Harderian_gland2.56957789
12MP0010678_abnormal_skin_adnexa2.50247699
13MP0003941_abnormal_skin_development2.47748094
14MP0005310_abnormal_salivary_gland2.46829170
15MP0005647_abnormal_sex_gland2.42326625
16MP0001293_anophthalmia2.33453874
17MP0008789_abnormal_olfactory_epithelium2.33204892
18MP0005394_taste/olfaction_phenotype2.20984510
19MP0005499_abnormal_olfactory_system2.20984510
20MP0000383_abnormal_hair_follicle2.20265736
21MP0004043_abnormal_pH_regulation2.19850715
22MP0003122_maternal_imprinting2.16081810
23MP0002006_tumorigenesis2.08976201
24MP0010352_gastrointestinal_tract_polyps2.07374780
25MP0009384_cardiac_valve_regurgitation2.06987682
26MP0000613_abnormal_salivary_gland2.06310092
27MP0002233_abnormal_nose_morphology2.05316349
28MP0003566_abnormal_cell_adhesion1.99069269
29MP0000534_abnormal_ureter_morphology1.88583164
30MP0005377_hearing/vestibular/ear_phenot1.86810447
31MP0003878_abnormal_ear_physiology1.86810447
32MP0003136_yellow_coat_color1.83841683
33MP0000566_synostosis1.79200508
34MP0010386_abnormal_urinary_bladder1.77210383
35MP0009053_abnormal_anal_canal1.76057807
36MP0000049_abnormal_middle_ear1.72459942
37MP0000778_abnormal_nervous_system1.70747380
38MP0003938_abnormal_ear_development1.70152361
39MP0001958_emphysema1.69926659
40MP0002060_abnormal_skin_morphology1.69623336
41MP0005367_renal/urinary_system_phenotyp1.65310929
42MP0000516_abnormal_urinary_system1.65310929
43MP0001286_abnormal_eye_development1.63366384
44MP0003755_abnormal_palate_morphology1.61136663
45MP0002697_abnormal_eye_size1.59658966
46MP0003283_abnormal_digestive_organ1.59341979
47MP0003890_abnormal_embryonic-extraembry1.53548548
48MP0002295_abnormal_pulmonary_circulatio1.53215495
49MP0003119_abnormal_digestive_system1.52921356
50MP0005076_abnormal_cell_differentiation1.52876230
51MP0006054_spinal_hemorrhage1.51715225
52MP0005623_abnormal_meninges_morphology1.51417217
53MP0002796_impaired_skin_barrier1.48149853
54MP0003942_abnormal_urinary_system1.46727251
55MP0001756_abnormal_urination1.42171293
56MP0005023_abnormal_wound_healing1.40185159
57MP0001299_abnormal_eye_distance/1.36399689
58MP0001346_abnormal_lacrimal_gland1.35599488
59MP0009780_abnormal_chondrocyte_physiolo1.33935358
60MP0004084_abnormal_cardiac_muscle1.33001839
61MP0005503_abnormal_tendon_morphology1.31620225
62MP0009379_abnormal_foot_pigmentation1.31408994
63MP0000767_abnormal_smooth_muscle1.30744922
64MP0002102_abnormal_ear_morphology1.29095842
65MP0000762_abnormal_tongue_morphology1.28243327
66MP0001765_abnormal_ion_homeostasis1.28118801
67MP0004133_heterotaxia1.27291142
68MP0003935_abnormal_craniofacial_develop1.21688267
69MP0010030_abnormal_orbit_morphology1.21404990
70MP0002084_abnormal_developmental_patter1.20348237
71MP0002009_preneoplasia1.20063767
72MP0009250_abnormal_appendicular_skeleto1.18326874
73MP0002098_abnormal_vibrissa_morphology1.18148019
74MP0003121_genomic_imprinting1.17919666
75MP0003045_fibrosis1.17233964
76MP0000631_abnormal_neuroendocrine_gland1.15969101
77MP0002116_abnormal_craniofacial_bone1.15957260
78MP0000432_abnormal_head_morphology1.15427617
79MP0002896_abnormal_bone_mineralization1.14372078
80MP0003861_abnormal_nervous_system1.13575483
81MP0004264_abnormal_extraembryonic_tissu1.13397198
82MP0000538_abnormal_urinary_bladder1.13161700
83MP0005257_abnormal_intraocular_pressure1.13086459
84MP0003385_abnormal_body_wall1.12150712
85MP0002132_abnormal_respiratory_system1.11654297
86MP0005197_abnormal_uvea_morphology1.10406677
87MP0005330_cardiomyopathy1.07599024
88MP0002111_abnormal_tail_morphology1.06410482
89MP0002085_abnormal_embryonic_tissue1.06317961
90MP0005391_vision/eye_phenotype1.05058543
91MP0001849_ear_inflammation1.04946513
92MP0005193_abnormal_anterior_eye1.04851713
93MP0002254_reproductive_system_inflammat1.04091454
94MP0000026_abnormal_inner_ear1.03544464
95MP0003315_abnormal_perineum_morphology1.01609200
96MP0003937_abnormal_limbs/digits/tail_de1.00662833
97MP0005508_abnormal_skeleton_morphology0.99584570
98MP0000462_abnormal_digestive_system0.99250157
99MP0000750_abnormal_muscle_regeneration0.98237694
100MP0004134_abnormal_chest_morphology0.97399990
101MP0001873_stomach_inflammation0.97274649
102MP0003115_abnormal_respiratory_system0.96348859
103MP0000467_abnormal_esophagus_morphology0.95128578
104MP0002109_abnormal_limb_morphology0.94344573
105MP0003567_abnormal_fetal_cardiomyocyte0.94052031
106MP0002282_abnormal_trachea_morphology0.93672565
107MP0000627_abnormal_mammary_gland0.93480458
108MP0000377_abnormal_hair_follicle0.92640893
109MP0002653_abnormal_ependyma_morphology0.89410518
110MP0005187_abnormal_penis_morphology0.88644773
111MP0000428_abnormal_craniofacial_morphol0.88264202
112MP0003091_abnormal_cell_migration0.87881615
113MP0001984_abnormal_olfaction0.87289618
114MP0008932_abnormal_embryonic_tissue0.86843347
115MP0001216_abnormal_epidermal_layer0.86320231
116MP0000163_abnormal_cartilage_morphology0.85636365
117MP0003453_abnormal_keratinocyte_physiol0.85600357
118MP0002089_abnormal_postnatal_growth/wei0.85432033
119MP0004036_abnormal_muscle_relaxation0.83754341
120MP0010771_integument_phenotype0.83569053
121MP0002234_abnormal_pharynx_morphology0.83036531
122MP0009672_abnormal_birth_weight0.82811690
123MP0000681_abnormal_thyroid_gland0.81576751
124MP0002135_abnormal_kidney_morphology0.81392892
125MP0002092_abnormal_eye_morphology0.81256183
126MP0000579_abnormal_nail_morphology0.81046042
127MP0000647_abnormal_sebaceous_gland0.80109285
128MP0003279_aneurysm0.78431295
129MP0009703_decreased_birth_body0.77781493
130MP0009764_decreased_sensitivity_to0.77232098
131MP0005220_abnormal_exocrine_pancreas0.76728772
132MP0002249_abnormal_larynx_morphology0.75820539
133MP0005501_abnormal_skin_physiology0.75634774
134MP0004087_abnormal_muscle_fiber0.75512450
135MP0002932_abnormal_joint_morphology0.75150556
136MP0003984_embryonic_growth_retardation0.73179378
137MP0002925_abnormal_cardiovascular_devel0.73129055
138MP0004215_abnormal_myocardial_fiber0.73108522
139MP0001529_abnormal_vocalization0.72960268
140MP0002136_abnormal_kidney_physiology0.72483973
141MP0002088_abnormal_embryonic_growth/wei0.72483888
142MP0003936_abnormal_reproductive_system0.71913328
143MP0000749_muscle_degeneration0.71872005
144MP0010630_abnormal_cardiac_muscle0.71818419
145MP0002108_abnormal_muscle_morphology0.71745253
146MP0000427_abnormal_hair_cycle0.71593688
147MP0002837_dystrophic_cardiac_calcinosis0.71076613
148MP0001672_abnormal_embryogenesis/_devel0.70445999
149MP0005380_embryogenesis_phenotype0.70445999
150MP0002163_abnormal_gland_morphology0.69695956
151MP0001340_abnormal_eyelid_morphology0.69249914
152MP0004197_abnormal_fetal_growth/weight/0.67704567
153MP0002081_perinatal_lethality0.67541497
154MP0001697_abnormal_embryo_size0.65285848
155MP0002152_abnormal_brain_morphology0.63965852
156MP0004858_abnormal_nervous_system0.63613804
157MP0005171_absent_coat_pigmentation0.62630878
158MP0002114_abnormal_axial_skeleton0.60239906
159MP0003123_paternal_imprinting0.60163550
160MP0002177_abnormal_outer_ear0.57584559
161MP0005195_abnormal_posterior_eye0.57395186
162MP0003880_abnormal_central_pattern0.56865672

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)4.95824901
2Nuclear cataract (HP:0100018)4.69131138
3Aortic dissection (HP:0002647)4.14661284
4Atrophic scars (HP:0001075)3.98804789
5Milia (HP:0001056)3.74288017
6Zonular cataract (HP:0010920)3.67792293
7Partial duplication of thumb phalanx (HP:0009944)3.66960787
8Partial duplication of the phalanx of hand (HP:0009999)3.35279898
9Right ventricular cardiomyopathy (HP:0011663)3.33517275
10Onycholysis (HP:0001806)3.26591699
11Coronal craniosynostosis (HP:0004440)3.18537751
12Aplasia involving bones of the extremities (HP:0009825)3.17109592
13Aplasia involving bones of the upper limbs (HP:0009823)3.17109592
14Aplasia of the phalanges of the hand (HP:0009802)3.17109592
15Septo-optic dysplasia (HP:0100842)3.16465434
16Ankle contracture (HP:0006466)3.15004315
17Rectal prolapse (HP:0002035)3.14981776
18Vitreoretinal degeneration (HP:0000655)3.11005145
19Broad thumb (HP:0011304)3.03622825
20Pili torti (HP:0003777)3.00215046
21Shallow orbits (HP:0000586)2.94111119
22Preaxial foot polydactyly (HP:0001841)2.92283095
23High anterior hairline (HP:0009890)2.81992519
24Protrusio acetabuli (HP:0003179)2.81568025
25Esophageal atresia (HP:0002032)2.81509828
26Premature rupture of membranes (HP:0001788)2.79766781
27Anophthalmia (HP:0000528)2.72699669
28Abnormality of the 2nd finger (HP:0004100)2.70472616
29Short hallux (HP:0010109)2.67125540
30Broad phalanges of the hand (HP:0009768)2.61175409
31Aneurysm (HP:0002617)2.60786189
32Trigonocephaly (HP:0000243)2.60371589
33Potter facies (HP:0002009)2.59817968
34Facial shape deformation (HP:0011334)2.59817968
35Broad finger (HP:0001500)2.57644937
36Subcapsular cataract (HP:0000523)2.57597946
37Cutaneous syndactyly (HP:0012725)2.53575422
38Broad metatarsal (HP:0001783)2.52412985
39Fragile nails (HP:0001808)2.50253722
40Cerebral aneurysm (HP:0004944)2.48946872
41Duplication of thumb phalanx (HP:0009942)2.47527051
42Absent septum pellucidum (HP:0001331)2.46930960
43Scapular winging (HP:0003691)2.46899411
44Maternal diabetes (HP:0009800)2.43675986
4511 pairs of ribs (HP:0000878)2.43579428
46Increased density of long bones (HP:0006392)2.42725041
47Hyporeflexia of lower limbs (HP:0002600)2.41546108
48Oligodactyly (HP:0012165)2.39439905
49Broad phalanx (HP:0006009)2.39304261
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.39061116
51Broad toe (HP:0001837)2.37615010
52Mixed hearing impairment (HP:0000410)2.37017227
53Subacute progressive viral hepatitis (HP:0006572)2.33795289
54Hepatoblastoma (HP:0002884)2.32171592
55Bifid tongue (HP:0010297)2.30896411
56Neonatal short-limb short stature (HP:0008921)2.29096009
57Fragile skin (HP:0001030)2.28596921
58Broad distal phalanx of finger (HP:0009836)2.27946457
59Broad long bones (HP:0005622)2.27869826
60Hypoplastic nipples (HP:0002557)2.26516174
61Stenosis of the external auditory canal (HP:0000402)2.25744825
62Broad hallux (HP:0010055)2.24966400
63Mildly elevated creatine phosphokinase (HP:0008180)2.23769762
64Synostosis of carpal bones (HP:0005048)2.20440948
65Missing ribs (HP:0000921)2.19397625
66Abnormality of the septum pellucidum (HP:0007375)2.18289888
67Polar cataract (HP:0010696)2.18272098
68Osteolytic defects of the hand bones (HP:0009699)2.13976042
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.13976042
70Hematochezia (HP:0002573)2.13903445
71Abnormality of the aortic arch (HP:0012303)2.13198310
72Abnormality of the lacrimal duct (HP:0011481)2.12775764
73Asymmetry of the thorax (HP:0001555)2.12096825
74Increased connective tissue (HP:0009025)2.11253158
75Type 1 muscle fiber predominance (HP:0003803)2.10862118
76Abnormality of the calcaneus (HP:0008364)2.10599407
77Ulnar bowing (HP:0003031)2.08268436
78Limited elbow extension (HP:0001377)2.08196358
79Fibular hypoplasia (HP:0003038)2.07805092
80Tracheomalacia (HP:0002779)2.07787588
81Rib fusion (HP:0000902)2.05957507
82Buphthalmos (HP:0000557)2.05939664
83Abnormality of incisor morphology (HP:0011063)2.05544688
84Cervical subluxation (HP:0003308)2.05525788
85Dilatation of the ascending aorta (HP:0005111)2.05517055
86Optic nerve hypoplasia (HP:0000609)2.05254713
87Myelomeningocele (HP:0002475)2.05195212
88Bronchomalacia (HP:0002780)2.05051084
89Aortic regurgitation (HP:0001659)2.04948433
90Overgrowth (HP:0001548)2.03985921
91Hypoplastic labia majora (HP:0000059)2.01349902
92Split foot (HP:0001839)2.01159281
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01093666
94Absent epiphyses (HP:0010577)2.01093666
95Deviation of the hallux (HP:0010051)2.00181981
96Reticulocytopenia (HP:0001896)1.99151594
97Mitral valve prolapse (HP:0001634)1.98994885
98Vertebral clefting (HP:0008428)1.98906451
99Abnormality of the labia majora (HP:0012881)1.98707222
100Abnormality of the proximal phalanges of the hand (HP:0009834)1.98541391
101Abnormality of the middle phalanges of the toes (HP:0010183)1.96787561
102Abnormality of the labia minora (HP:0012880)1.96599953
103Abnormality of the distal phalanx of the thumb (HP:0009617)1.95959113
104Mesangial abnormality (HP:0001966)1.95455468
105Hypoplastic pelvis (HP:0008839)1.93687444
106Midline defect of the nose (HP:0004122)1.93502468
107Back pain (HP:0003418)1.93410845
108Bicuspid aortic valve (HP:0001647)1.92292974
109Plantar hyperkeratosis (HP:0007556)1.91251198
110Tarsal synostosis (HP:0008368)1.90565835
111Pterygium (HP:0001059)1.90442581
112Oligodactyly (hands) (HP:0001180)1.89848966
113Abnormality of the nasolacrimal system (HP:0000614)1.89600500
114Shawl scrotum (HP:0000049)1.89447348
115Abnormality of dentin (HP:0010299)1.88611886
116Germ cell neoplasia (HP:0100728)1.88037437
117Diastasis recti (HP:0001540)1.87349691
118Irregular epiphyses (HP:0010582)1.86444776
119Sparse lateral eyebrow (HP:0005338)1.86187388
120Renal hypoplasia (HP:0000089)1.85980463
121Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85454940
122Short 4th metacarpal (HP:0010044)1.85454940
123Renal dysplasia (HP:0000110)1.84754064
124Omphalocele (HP:0001539)1.84116964
125Camptodactyly of toe (HP:0001836)1.83008981
126Labial hypoplasia (HP:0000066)1.82913810
127Facial diplegia (HP:0001349)1.82234634
128Taurodontia (HP:0000679)1.82188590
129Abnormality of permanent molar morphology (HP:0011071)1.82188590
130Abnormality of the dental root (HP:0006486)1.82188590
131Abnormality of oral frenula (HP:0000190)1.81967878
132Aplasia/Hypoplasia of the ulna (HP:0006495)1.81310118
133Wormian bones (HP:0002645)1.80695421
134Gastrointestinal atresia (HP:0002589)1.80597374
135Congenital cataract (HP:0000519)1.79793067
136Spinal rigidity (HP:0003306)1.79250709
137Aplasia of the musculature (HP:0100854)1.78750140
138Abnormality of the antihelix (HP:0009738)1.78554852
139Bilateral microphthalmos (HP:0007633)1.78353361
140Alacrima (HP:0000522)1.78212000
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78122092
142Ectopic kidney (HP:0000086)1.78042761
143Hallux valgus (HP:0001822)1.77674591
144Vertebral hypoplasia (HP:0008417)1.76429876
145Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76429876
146Cutaneous finger syndactyly (HP:0010554)1.74710676
147Hypoplastic female external genitalia (HP:0012815)1.73478794
148Abnormal hair laboratory examination (HP:0003328)1.73271768
149Vaginal atresia (HP:0000148)1.71878323
150Abnormality of the axillary hair (HP:0100134)1.71781124
151Abnormality of secondary sexual hair (HP:0009888)1.71781124
152Turricephaly (HP:0000262)1.70445977
153Abnormality of the ischium (HP:0003174)1.70430842
154Triphalangeal thumb (HP:0001199)1.70008983
155Overriding aorta (HP:0002623)1.69512114
156Achilles tendon contracture (HP:0001771)1.69278536
157Radial bowing (HP:0002986)1.69048014
158Absent radius (HP:0003974)1.68903551
159Abnormality of the diencephalon (HP:0010662)1.68570648
160Ureteral stenosis (HP:0000071)1.68382196
161Synostosis involving bones of the lower limbs (HP:0009138)1.68124827
162Synostosis involving bones of the feet (HP:0009140)1.68124827
163Enlarged penis (HP:0000040)1.65585168
164Broad ribs (HP:0000885)1.65247113
165Lymphangioma (HP:0100764)1.64613938
166Wide anterior fontanel (HP:0000260)1.64413860
167Aplasia/Hypoplasia of the scapulae (HP:0006713)1.63176730
168Hypoplastic scapulae (HP:0000882)1.63176730
169Abnormality of the phalanges of the 2nd finger (HP:0009541)1.62284926
170Abnormality of the intrinsic pathway (HP:0010989)1.60715251
171Abnormality of the 4th metacarpal (HP:0010012)1.60475503
172Biliary tract neoplasm (HP:0100574)1.59544509
173Selective tooth agenesis (HP:0001592)1.58946168
174Hypoplasia of the pons (HP:0012110)1.57933533
175Choanal stenosis (HP:0000452)1.57706308
176Hypoplasia of the ulna (HP:0003022)1.57662516
177Advanced eruption of teeth (HP:0006288)1.57539830
178Abnormality of the shoulder girdle musculature (HP:0001435)1.57335761
179Ureteral obstruction (HP:0006000)1.56705922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.24108177
2AKT34.76533571
3LATS14.08705551
4FRK3.95505731
5MST43.66417775
6SIK13.33169664
7TTN3.00642581
8EPHA42.97023421
9PNCK2.80207688
10MYLK2.71107718
11EEF2K2.68440497
12CASK2.50303031
13MKNK12.15494169
14TRIB32.13239138
15CDC72.10925423
16LMTK21.97965538
17MAP3K101.93980236
18EPHA21.83550259
19DMPK1.80323197
20LRRK21.78876210
21WEE11.69833017
22EPHB21.65493727
23NUAK11.64620596
24TAOK31.62959311
25MAPKAPK31.60668925
26FER1.60198220
27TYRO31.59020786
28PDGFRA1.54900989
29PKN21.53640574
30PTK61.51297360
31MAP3K21.49618945
32TNIK1.48597357
33PAK21.44846603
34PIK3CA1.40711940
35STK101.40523640
36WNK31.37129731
37SCYL21.34014912
38RPS6KB21.32193934
39FGFR21.32014815
40SRPK11.23863283
41PLK41.23727872
42BCKDK1.22467351
43STK31.22427321
44TRPM71.22131078
45STK391.21703204
46CAMK1G1.21436639
47MKNK21.21152066
48FLT31.20561577
49PLK21.20187103
50PASK1.19285671
51TTK1.18160885
52MAPK151.16962055
53MET1.15010636
54LATS21.14935851
55ROCK11.14687755
56DDR21.13304106
57MST1R1.12778522
58STK38L1.11460906
59CDK191.09344641
60MAP3K41.07010709
61MAP3K91.06555188
62RIPK11.06370537
63TESK11.03526666
64BRD41.03423319
65ROCK21.03316470
66PDK21.02526642
67PLK30.96253503
68MAP3K30.91322770
69DYRK20.88247869
70PTK20.86610366
71VRK20.85588116
72NTRK20.80920935
73BMX0.75193276
74RPS6KA20.73972027
75PIK3CG0.73324025
76FGFR10.72241262
77BRSK10.71851179
78NEK20.70179692
79ILK0.68206723
80TESK20.67359802
81NLK0.66403625
82MTOR0.66015637
83TGFBR10.64615341
84PLK10.63441313
85ERBB20.61078802
86KSR10.57498951
87ATR0.57324333
88PAK30.56116438
89CHEK20.56111301
90PDGFRB0.56030198
91CSNK1G10.54950408
92NEK60.54261500
93JAK30.53405123
94VRK10.53073248
95PRKCI0.52800187
96EPHB10.52068098
97TAF10.51687056
98STK110.51449591
99ZAK0.50284858
100MAP3K80.49963879
101BMPR1B0.49026319
102WNK40.48491422
103TGFBR20.48074791
104MAP2K20.47808610
105DYRK30.47336166
106CDC42BPA0.47008672
107NEK10.46899752
108STK240.46817860
109CDK30.46242223
110WNK10.46051676
111ATM0.45410156
112MARK10.45355135
113LIMK10.44215335
114RET0.43764111
115PHKG20.43465484
116PHKG10.43465484
117MAP2K70.43345586
118PDK30.41560604
119PDK40.41560604
120MELK0.41493517
121ARAF0.40814105
122PRKDC0.40784019
123CHEK10.40363025
124PRKCE0.39970603
125BRAF0.38146675
126MAP3K70.38145955
127ICK0.37715235
128CDK10.36609352
129BUB10.35519716
130MAP2K10.33773354
131BRSK20.33628726
132NTRK10.33515266
133RPS6KC10.33275308
134RPS6KL10.33275308
135CDK20.32884805
136CSNK1E0.31489770
137ERBB40.30996072
138FGFR30.30763100
139CAMK1D0.30689667
140PRKD10.30675781
141INSR0.29008391
142TRIM280.28982574
143JAK20.28776334
144EPHA30.27726985
145AURKB0.27147871
146AKT20.26902213
147JAK10.26697755
148BCR0.26154319
149PAK40.25344948
150ADRBK10.23913334
151OBSCN0.23754692
152NEK90.23753119
153PAK10.23608030
154CSF1R0.23397954
155STK380.23274154
156IGF1R0.23197541
157RPS6KA10.23046326
158MATK0.22687456

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.91351112
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.53961854
3* ECM-receptor interaction_Homo sapiens_hsa045122.54997506
4Bladder cancer_Homo sapiens_hsa052192.34413671
5* Focal adhesion_Homo sapiens_hsa045102.28746540
6Ribosome_Homo sapiens_hsa030102.27624686
7Adherens junction_Homo sapiens_hsa045202.23709561
8Sulfur metabolism_Homo sapiens_hsa009202.17685735
9Hippo signaling pathway_Homo sapiens_hsa043902.10221612
10Tight junction_Homo sapiens_hsa045302.07101301
11Prostate cancer_Homo sapiens_hsa052152.02435215
12Endometrial cancer_Homo sapiens_hsa052131.96734366
13* Small cell lung cancer_Homo sapiens_hsa052221.89650809
14N-Glycan biosynthesis_Homo sapiens_hsa005101.88692795
15Proteoglycans in cancer_Homo sapiens_hsa052051.85885775
16Basal cell carcinoma_Homo sapiens_hsa052171.82424557
17DNA replication_Homo sapiens_hsa030301.81563125
18Steroid biosynthesis_Homo sapiens_hsa001001.77303517
19TGF-beta signaling pathway_Homo sapiens_hsa043501.69467851
20* Amoebiasis_Homo sapiens_hsa051461.63194990
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58152277
22Protein export_Homo sapiens_hsa030601.56257180
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54891623
24Vibrio cholerae infection_Homo sapiens_hsa051101.54566881
25Thyroid hormone synthesis_Homo sapiens_hsa049181.53024706
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49911949
27Fanconi anemia pathway_Homo sapiens_hsa034601.46606361
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.43386088
29Mismatch repair_Homo sapiens_hsa034301.38849011
30Non-homologous end-joining_Homo sapiens_hsa034501.35403146
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33891129
32Cardiac muscle contraction_Homo sapiens_hsa042601.30040025
33Nitrogen metabolism_Homo sapiens_hsa009101.29289025
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26614907
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26259850
36* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24795802
37Dilated cardiomyopathy_Homo sapiens_hsa054141.23350215
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19816959
39Pancreatic cancer_Homo sapiens_hsa052121.18999028
40Wnt signaling pathway_Homo sapiens_hsa043101.17737800
41* Protein digestion and absorption_Homo sapiens_hsa049741.17563593
42MicroRNAs in cancer_Homo sapiens_hsa052061.17297542
43Cell cycle_Homo sapiens_hsa041101.16243403
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15767716
45Glioma_Homo sapiens_hsa052141.15237910
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15121068
47Chronic myeloid leukemia_Homo sapiens_hsa052201.14900653
48Melanoma_Homo sapiens_hsa052181.13330513
49mTOR signaling pathway_Homo sapiens_hsa041501.11933848
50Nucleotide excision repair_Homo sapiens_hsa034201.11678741
51Hedgehog signaling pathway_Homo sapiens_hsa043401.11620968
52* Pathways in cancer_Homo sapiens_hsa052001.11157471
53Renin-angiotensin system_Homo sapiens_hsa046141.10112564
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09290616
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04528926
56Non-small cell lung cancer_Homo sapiens_hsa052231.04324912
57Biosynthesis of amino acids_Homo sapiens_hsa012301.03071610
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99863721
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.97805276
60ErbB signaling pathway_Homo sapiens_hsa040120.97313549
61RNA transport_Homo sapiens_hsa030130.94320906
62Insulin resistance_Homo sapiens_hsa049310.93848958
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92165012
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91571448
65Spliceosome_Homo sapiens_hsa030400.90771233
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.90612190
67* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88144545
68Thyroid cancer_Homo sapiens_hsa052160.87618649
69Toxoplasmosis_Homo sapiens_hsa051450.86515002
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.85692994
71mRNA surveillance pathway_Homo sapiens_hsa030150.85464040
72Melanogenesis_Homo sapiens_hsa049160.80142567
73p53 signaling pathway_Homo sapiens_hsa041150.79159341
74Fatty acid biosynthesis_Homo sapiens_hsa000610.78353884
75Pyruvate metabolism_Homo sapiens_hsa006200.77991714
76Estrogen signaling pathway_Homo sapiens_hsa049150.77421759
77Notch signaling pathway_Homo sapiens_hsa043300.76624571
78Homologous recombination_Homo sapiens_hsa034400.75761293
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75440274
80HIF-1 signaling pathway_Homo sapiens_hsa040660.75088291
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74723484
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74182836
83Basal transcription factors_Homo sapiens_hsa030220.73058448
84Hepatitis C_Homo sapiens_hsa051600.72527766
85Huntingtons disease_Homo sapiens_hsa050160.72019844
86AMPK signaling pathway_Homo sapiens_hsa041520.71178522
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70688738
88RNA degradation_Homo sapiens_hsa030180.70677187
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68986281
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68585944
91Gap junction_Homo sapiens_hsa045400.68212231
92Acute myeloid leukemia_Homo sapiens_hsa052210.66014610
93Viral myocarditis_Homo sapiens_hsa054160.65788543
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65748614
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64847648
96Platelet activation_Homo sapiens_hsa046110.61773344
97Propanoate metabolism_Homo sapiens_hsa006400.60486639
98Collecting duct acid secretion_Homo sapiens_hsa049660.60389147
99FoxO signaling pathway_Homo sapiens_hsa040680.59771340
100Inositol phosphate metabolism_Homo sapiens_hsa005620.59590225
101Renal cell carcinoma_Homo sapiens_hsa052110.59384296
102Gastric acid secretion_Homo sapiens_hsa049710.58820584
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58737651
104Rap1 signaling pathway_Homo sapiens_hsa040150.58734607
105Fatty acid degradation_Homo sapiens_hsa000710.58566558
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.58510814
107Prolactin signaling pathway_Homo sapiens_hsa049170.57928224
108Base excision repair_Homo sapiens_hsa034100.57785089
109Colorectal cancer_Homo sapiens_hsa052100.57612043
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56145554
111Carbon metabolism_Homo sapiens_hsa012000.55696947
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55671082
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55510198
114Axon guidance_Homo sapiens_hsa043600.54771969
115Fructose and mannose metabolism_Homo sapiens_hsa000510.53988191
116One carbon pool by folate_Homo sapiens_hsa006700.52748169
117Insulin signaling pathway_Homo sapiens_hsa049100.52297488
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51993686
119Lysine degradation_Homo sapiens_hsa003100.51606617
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51522746
121Sulfur relay system_Homo sapiens_hsa041220.51225266
122Phototransduction_Homo sapiens_hsa047440.49493455
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49251229
124Other glycan degradation_Homo sapiens_hsa005110.48963130
125Parkinsons disease_Homo sapiens_hsa050120.48468835
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47311835
127Arginine and proline metabolism_Homo sapiens_hsa003300.47311624
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45373126
129Circadian rhythm_Homo sapiens_hsa047100.45086729
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44576448
131Choline metabolism in cancer_Homo sapiens_hsa052310.42992376
132Endocytosis_Homo sapiens_hsa041440.41961298
133VEGF signaling pathway_Homo sapiens_hsa043700.40460339
134Fatty acid metabolism_Homo sapiens_hsa012120.39169659
135HTLV-I infection_Homo sapiens_hsa051660.39068506
136RNA polymerase_Homo sapiens_hsa030200.38246560
137Oocyte meiosis_Homo sapiens_hsa041140.36806421
138Arginine biosynthesis_Homo sapiens_hsa002200.36321612
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36069678
140Renin secretion_Homo sapiens_hsa049240.35945905
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.35033569
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34590288
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34571505
144Galactose metabolism_Homo sapiens_hsa000520.32563940
145Alcoholism_Homo sapiens_hsa050340.32364990
146Vitamin digestion and absorption_Homo sapiens_hsa049770.31603140
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29979260
148Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29097027
149cAMP signaling pathway_Homo sapiens_hsa040240.28744369
150Glycerolipid metabolism_Homo sapiens_hsa005610.28096917
151Alzheimers disease_Homo sapiens_hsa050100.27801722
152Retinol metabolism_Homo sapiens_hsa008300.25982277
153Oxidative phosphorylation_Homo sapiens_hsa001900.25662944
154Purine metabolism_Homo sapiens_hsa002300.24478310

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