COL4A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1otic vesicle formation (GO:0030916)7.99152696
2mesenchymal-epithelial cell signaling (GO:0060638)7.85640682
3regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.95925499
4negative regulation of stress fiber assembly (GO:0051497)6.67836335
5lateral sprouting from an epithelium (GO:0060601)6.62962400
6epithelial cell differentiation involved in kidney development (GO:0035850)6.61961581
7peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.60660790
8positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr6.45213905
9negative regulation of Rho protein signal transduction (GO:0035024)6.42897936
10radial glial cell differentiation (GO:0060019)6.22683300
11muscle cell fate commitment (GO:0042693)6.07061754
12regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 5.63390486
13lung epithelium development (GO:0060428)5.57404584
14endothelium development (GO:0003158)5.52659252
15surfactant homeostasis (GO:0043129)5.45077092
16negative regulation of actin filament bundle assembly (GO:0032232)5.36162267
17striated muscle hypertrophy (GO:0014897)5.26251485
18camera-type eye morphogenesis (GO:0048593)5.25567592
19embryonic camera-type eye development (GO:0031076)5.12851299
20regulation of axon guidance (GO:1902667)5.10671198
21organ growth (GO:0035265)5.07412650
22bicarbonate transport (GO:0015701)4.88732355
23actin-myosin filament sliding (GO:0033275)4.85837376
24muscle filament sliding (GO:0030049)4.85837376
25metanephric epithelium development (GO:0072207)4.84201168
26limb bud formation (GO:0060174)4.79958589
27induction of positive chemotaxis (GO:0050930)4.78688096
28muscle hypertrophy (GO:0014896)4.78466260
29protein localization to cell surface (GO:0034394)4.78182660
30peripheral nervous system axon ensheathment (GO:0032292)4.77899825
31myelination in peripheral nervous system (GO:0022011)4.77899825
32negative regulation of axon guidance (GO:1902668)4.70516770
33striated muscle adaptation (GO:0014888)4.70364593
34neuronal ion channel clustering (GO:0045161)4.54980218
35chemical homeostasis within a tissue (GO:0048875)4.41982027
36genitalia morphogenesis (GO:0035112)4.39312792
37negative regulation of metanephros development (GO:0072217)4.33693636
38facial nerve structural organization (GO:0021612)4.30292151
39regulation of mitochondrial depolarization (GO:0051900)4.27915126
40positive regulation of cell junction assembly (GO:1901890)4.23944307
41positive regulation of focal adhesion assembly (GO:0051894)4.23944307
42cell differentiation involved in kidney development (GO:0061005)4.20044860
43kidney mesenchyme development (GO:0072074)4.19944722
44mesonephros development (GO:0001823)4.18890943
45actin-mediated cell contraction (GO:0070252)4.15356829
46excretion (GO:0007588)4.12686619
47myofibril assembly (GO:0030239)4.12579462
48vascular endothelial growth factor signaling pathway (GO:0038084)4.05135177
49regulation of axon extension involved in axon guidance (GO:0048841)4.04827765
50regulation of skeletal muscle contraction (GO:0014819)4.03018318
51positive regulation of adherens junction organization (GO:1903393)4.02824193
52sarcoplasmic reticulum calcium ion transport (GO:0070296)3.94970025
53regulation of relaxation of muscle (GO:1901077)3.94750310
54negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.94588027
55positive regulation of protein kinase C signaling (GO:0090037)3.89379417
56short-term memory (GO:0007614)3.87497764
57lung secretory cell differentiation (GO:0061140)3.86307634
58postsynaptic membrane organization (GO:0001941)3.82722543
59cellular response to reactive nitrogen species (GO:1902170)3.82303780
60metanephric mesenchyme development (GO:0072075)3.76971830
61regulation of apoptotic process involved in morphogenesis (GO:1902337)3.75588108
62response to mercury ion (GO:0046689)3.74861643
63muscle adaptation (GO:0043500)3.74079806
64endothelial cell chemotaxis (GO:0035767)3.71508950
65kidney morphogenesis (GO:0060993)3.71438724
66nephron epithelium development (GO:0072009)3.69708291
67regulation of glomerular filtration (GO:0003093)3.66891871
68positive regulation of cell adhesion mediated by integrin (GO:0033630)3.65633910
69metanephric tubule development (GO:0072170)3.65154304
70metanephric nephron tubule development (GO:0072234)3.65154304
71positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.64843233
72regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.64264785
73regulation of ruffle assembly (GO:1900027)3.60818613
74branch elongation of an epithelium (GO:0060602)3.59384519
75keratinocyte proliferation (GO:0043616)3.58371684
76metanephric nephron epithelium development (GO:0072243)3.54662799
77lymphangiogenesis (GO:0001946)3.54301361
78actin filament-based movement (GO:0030048)3.53199411
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.52743432
80embryonic digestive tract morphogenesis (GO:0048557)3.52061860
81angiotensin maturation (GO:0002003)3.51344057
82regulation of cell proliferation involved in kidney development (GO:1901722)3.50792421
83response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.49495424
84auditory receptor cell stereocilium organization (GO:0060088)3.48378701
85skeletal muscle contraction (GO:0003009)3.47131979
86white fat cell differentiation (GO:0050872)3.46660743
87cranial nerve structural organization (GO:0021604)3.43984124
88negative regulation of homotypic cell-cell adhesion (GO:0034111)3.43706448
89presynaptic membrane assembly (GO:0097105)3.42116684
90lymph vessel development (GO:0001945)3.40905681
91myoblast fusion (GO:0007520)3.36062079
92cellular response to nitric oxide (GO:0071732)3.35179966
93renal system process involved in regulation of blood volume (GO:0001977)3.34476157
94renal filtration (GO:0097205)3.30258598
95thyroid gland development (GO:0030878)3.28161630
96positive regulation of metanephros development (GO:0072216)3.27995967
97coronary vasculature morphogenesis (GO:0060977)3.26576068
98positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.25894491
99phosphate ion transmembrane transport (GO:0035435)3.25655138
100organ induction (GO:0001759)3.24905596
101negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.21428567
102organ formation (GO:0048645)3.17602890
103pattern specification involved in kidney development (GO:0061004)3.16945640
104regulation of mesenchymal cell apoptotic process (GO:2001053)3.16203902
105regulation of male gonad development (GO:2000018)3.16083879
106smooth muscle cell differentiation (GO:0051145)3.15217114
107phosphate ion transport (GO:0006817)3.14414247
108cell differentiation involved in metanephros development (GO:0072202)3.13070455
109positive regulation of p38MAPK cascade (GO:1900745)3.12037054
110sarcomere organization (GO:0045214)3.09569288
111cardiac myofibril assembly (GO:0055003)3.05958821
112neuron remodeling (GO:0016322)3.03613461
113morphogenesis of an epithelial fold (GO:0060571)3.02941699
114mesodermal cell differentiation (GO:0048333)3.02573624
115positive regulation of steroid hormone secretion (GO:2000833)3.00590147
116response to inactivity (GO:0014854)2.99702017
117venous blood vessel morphogenesis (GO:0048845)2.99488226
118positive regulation of digestive system process (GO:0060456)2.97913191
119negative regulation of cell-matrix adhesion (GO:0001953)2.97893007
120mesenchymal to epithelial transition (GO:0060231)2.97806142
121regulation of actin filament-based movement (GO:1903115)2.97356417
122ERK1 and ERK2 cascade (GO:0070371)2.96939936
123smooth muscle tissue development (GO:0048745)2.96531292
124mesenchymal cell differentiation involved in kidney development (GO:0072161)2.95532804
125mesenchymal cell differentiation involved in renal system development (GO:2001012)2.95532804
126mesenchymal cell differentiation (GO:0048762)2.95413928
127syncytium formation by plasma membrane fusion (GO:0000768)2.94631516
128glomerular filtration (GO:0003094)2.93454929
129positive regulation of male gonad development (GO:2000020)2.93413555
130regulation of digestive system process (GO:0044058)2.89630947
131regulation of Rho protein signal transduction (GO:0035023)2.89583491
132regulation of keratinocyte proliferation (GO:0010837)2.88804539
133actomyosin structure organization (GO:0031032)2.87471085
134regulation of glomerulus development (GO:0090192)2.87366329
135diaphragm development (GO:0060539)2.85631317
136negative regulation of axon extension involved in axon guidance (GO:0048843)2.85187843
137regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85174237
138epithelial tube formation (GO:0072175)2.85053057
139response to nitric oxide (GO:0071731)2.83356824
140striated muscle contraction (GO:0006941)2.83328566
141response to epinephrine (GO:0071871)2.81835178
142presynaptic membrane organization (GO:0097090)2.81523662
143axis elongation (GO:0003401)2.81237543
144positive regulation of mesonephros development (GO:0061213)2.79962813
145cell adhesion mediated by integrin (GO:0033627)2.79898208
146cellular hyperosmotic response (GO:0071474)2.78248730
147kidney epithelium development (GO:0072073)2.78091443
148regulation of mesonephros development (GO:0061217)2.77722882
149negative regulation of kidney development (GO:0090185)2.77377842
150wound healing, spreading of epidermal cells (GO:0035313)2.75575603
151cell migration involved in sprouting angiogenesis (GO:0002042)2.74724108
152lung vasculature development (GO:0060426)2.72761044
153regulation of platelet aggregation (GO:0090330)2.71253442
154positive regulation of vascular permeability (GO:0043117)2.70323225
155polyol transport (GO:0015791)2.68272203
156nucleus localization (GO:0051647)2.68248644
157cell migration involved in heart development (GO:0060973)2.65949800
158regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.65055905
159activation of Rac GTPase activity (GO:0032863)2.64494676
160establishment of nucleus localization (GO:0040023)2.63581927
161positive regulation of systemic arterial blood pressure (GO:0003084)2.63503407
162dopaminergic neuron differentiation (GO:0071542)2.62799277
163omega-hydroxylase P450 pathway (GO:0097267)2.62409778
164sprouting angiogenesis (GO:0002040)2.62292882
165regulation of endothelial cell chemotaxis (GO:2001026)2.61188947
166regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.60894565
167regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.60661610
168nephron tubule development (GO:0072080)2.59508214
169aminoglycoside antibiotic metabolic process (GO:0030647)2.58626282
170vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55414466
171negative regulation of chemotaxis (GO:0050922)2.53138920
172negative regulation of platelet activation (GO:0010544)2.52505579
173regulation of pigment cell differentiation (GO:0050932)2.49680325
174retina vasculature morphogenesis in camera-type eye (GO:0061299)2.48846407
175ureteric bud development (GO:0001657)2.48592965
176T-helper 1 type immune response (GO:0042088)2.47034686
177regulation of alkaline phosphatase activity (GO:0010692)2.45838707
178renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.45463276
179positive regulation of smooth muscle cell migration (GO:0014911)2.44409473
180drug transmembrane transport (GO:0006855)2.44076022
181phospholipid scrambling (GO:0017121)2.43090913
182mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.41183728
183regulation of inositol phosphate biosynthetic process (GO:0010919)2.40957114
184reflex (GO:0060004)2.40893330
185glomerular visceral epithelial cell development (GO:0072015)18.4101135
186glomerular epithelial cell development (GO:0072310)16.3930117
187* glomerular basement membrane development (GO:0032836)11.9819377
188glomerulus development (GO:0032835)10.8336179
189skeletal muscle adaptation (GO:0043501)10.0897247

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89554570
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.25940777
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71388151
4WT1_19549856_ChIP-ChIP_CCG9911_Human2.70882927
5GBX2_23144817_ChIP-Seq_PC3_Human2.67477585
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.58095911
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.56813155
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42067956
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38730793
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38730793
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35195032
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29254450
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29035940
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28709872
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28437488
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24585445
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.23385759
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.18604086
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16433506
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02156631
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.98720529
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97198794
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96713012
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.95256152
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90139764
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87872069
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87802325
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.87280746
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87258712
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.85699318
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85052736
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.75690992
33AR_21572438_ChIP-Seq_LNCaP_Human1.73346673
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.73071356
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.72003883
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.72003883
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71195304
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70455910
39TAF15_26573619_Chip-Seq_HEK293_Human1.69894357
40* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.67731541
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62661124
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61858363
43EGR1_19032775_ChIP-ChIP_M12_Human1.60875421
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.60043214
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58208180
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56667173
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.54427042
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53904499
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52213901
50* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51909033
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48534696
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45937396
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43542970
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43072228
55* FLI1_27457419_Chip-Seq_LIVER_Mouse1.42755164
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41740492
57SMAD3_21741376_ChIP-Seq_HESCs_Human1.40982332
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.40107416
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.39023305
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37612548
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36102644
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35786920
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34486252
64TP53_16413492_ChIP-PET_HCT116_Human1.33923211
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33080882
66TP53_18474530_ChIP-ChIP_U2OS_Human1.32733533
67CLOCK_20551151_ChIP-Seq_293T_Human1.32579676
68RNF2_27304074_Chip-Seq_NSC_Mouse1.29210989
69* NANOG_18555785_Chip-Seq_ESCs_Mouse1.28890523
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27479722
71* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26577202
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.26035498
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25999697
74P300_19829295_ChIP-Seq_ESCs_Human1.25063640
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24829028
76* EP300_21415370_ChIP-Seq_HL-1_Mouse1.24085282
77AHR_22903824_ChIP-Seq_MCF-7_Human1.23307675
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23170459
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22479707
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.22077520
81CJUN_26792858_Chip-Seq_BT549_Human1.21732211
82* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21721900
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20748016
84* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19790693
85* TCF4_18268006_ChIP-ChIP_LS174T_Human1.19544564
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.19334744
87* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19042888
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19010331
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18688793
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18688793
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17160839
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16978454
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.16075200
94RUNX_20019798_ChIP-Seq_JUKART_Human1.15209811
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14316175
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.13746190
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13693375
98* NFE2_27457419_Chip-Seq_LIVER_Mouse1.12694768
99SMAD4_21799915_ChIP-Seq_A2780_Human1.12337604
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.12018135
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.11548224
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10078001
103KDM2B_26808549_Chip-Seq_REH_Human1.09267575
104* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07811347
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.06851098
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06841690
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05809316
108* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05336181
109* P53_22387025_ChIP-Seq_ESCs_Mouse1.05001328
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04770279
111* E2F1_18555785_Chip-Seq_ESCs_Mouse1.04658681
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03912455
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.03717241
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02929008
115SMAD_19615063_ChIP-ChIP_OVARY_Human1.02843824
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02707515
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02597869
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02596980
119* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02352935
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01773139
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01479783
122RXR_22108803_ChIP-Seq_LS180_Human1.00641111
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00430656
124* CMYC_18555785_Chip-Seq_ESCs_Mouse0.99933451
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99084551
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98206772
127IGF1R_20145208_ChIP-Seq_DFB_Human0.97960189
128* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97816319
129NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97292244
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96182695
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95009482
132* P300_18555785_Chip-Seq_ESCs_Mouse0.94963761
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94685330
134DROSHA_22980978_ChIP-Seq_HELA_Human0.94452636
135* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93969330
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92969117
137* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92957255
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.92648589
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.92610530
140ER_23166858_ChIP-Seq_MCF-7_Human0.92474192
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92367412
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91558602
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91346323
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90600482
145* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90297485
146* STAT3_18555785_Chip-Seq_ESCs_Mouse0.90209031
147ZNF274_21170338_ChIP-Seq_K562_Hela0.89759742
148STAT3_23295773_ChIP-Seq_U87_Human0.89026729
149SOX2_20726797_ChIP-Seq_SW620_Human0.88916243
150RUNX2_22187159_ChIP-Seq_PCA_Human0.88861937
151KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88492267
152RXR_22158963_ChIP-Seq_LIVER_Mouse0.87933208
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86937276
154* SOX2_21211035_ChIP-Seq_LN229_Gbm0.85441183
155FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84224421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure5.76915166
2MP0005623_abnormal_meninges_morphology3.92889261
3MP0005409_darkened_coat_color3.83828930
4MP0003136_yellow_coat_color3.59881473
5MP0009379_abnormal_foot_pigmentation3.57083243
6MP0001879_abnormal_lymphatic_vessel3.47071060
7MP0010368_abnormal_lymphatic_system3.37049963
8MP0003646_muscle_fatigue3.23983002
9MP0005248_abnormal_Harderian_gland3.08922994
10MP0003724_increased_susceptibility_to2.91011417
11MP0002132_abnormal_respiratory_system2.71587902
12MP0001188_hyperpigmentation2.57949102
13MP0003880_abnormal_central_pattern2.52305639
14* MP0002136_abnormal_kidney_physiology2.43279502
15MP0004043_abnormal_pH_regulation2.40817383
16MP0004145_abnormal_muscle_electrophysio2.37433931
17MP0004381_abnormal_hair_follicle2.32428065
18MP0000749_muscle_degeneration2.24226665
19MP0000751_myopathy2.12694184
20MP0002332_abnormal_exercise_endurance2.09735670
21* MP0009643_abnormal_urine_homeostasis2.09193849
22MP0003941_abnormal_skin_development2.03588287
23MP0003942_abnormal_urinary_system2.02910174
24* MP0004272_abnormal_basement_membrane2.00210438
25* MP0000230_abnormal_systemic_arterial1.98673386
26* MP0005332_abnormal_amino_acid1.93260689
27MP0009384_cardiac_valve_regurgitation1.87483960
28MP0001958_emphysema1.80671192
29MP0003879_abnormal_hair_cell1.79258594
30MP0001765_abnormal_ion_homeostasis1.77790271
31MP0000013_abnormal_adipose_tissue1.75606956
32MP0003938_abnormal_ear_development1.72055321
33MP0002277_abnormal_respiratory_mucosa1.71582676
34MP0002837_dystrophic_cardiac_calcinosis1.70636462
35* MP0002135_abnormal_kidney_morphology1.69420635
36MP0002009_preneoplasia1.67836521
37MP0002909_abnormal_adrenal_gland1.67690922
38MP0004087_abnormal_muscle_fiber1.67623227
39MP0000747_muscle_weakness1.62266854
40MP0000534_abnormal_ureter_morphology1.59857207
41MP0002138_abnormal_hepatobiliary_system1.58646144
42MP0000566_synostosis1.57330371
43MP0002106_abnormal_muscle_physiology1.51066909
44MP0000537_abnormal_urethra_morphology1.50732930
45MP0003045_fibrosis1.50663928
46MP0005330_cardiomyopathy1.48749584
47MP0005377_hearing/vestibular/ear_phenot1.48130567
48MP0003878_abnormal_ear_physiology1.48130567
49MP0004084_abnormal_cardiac_muscle1.46390302
50MP0005369_muscle_phenotype1.45348938
51MP0004885_abnormal_endolymph1.45251469
52MP0005595_abnormal_vascular_smooth1.45069724
53MP0005165_increased_susceptibility_to1.41485838
54MP0008995_early_reproductive_senescence1.39924865
55MP0002108_abnormal_muscle_morphology1.38114733
56MP0002269_muscular_atrophy1.37174558
57MP0002177_abnormal_outer_ear1.35239326
58MP0000049_abnormal_middle_ear1.34851069
59MP0000759_abnormal_skeletal_muscle1.33219558
60MP0006292_abnormal_olfactory_placode1.31960970
61MP0000678_abnormal_parathyroid_gland1.30689122
62MP0006072_abnormal_retinal_apoptosis1.29353799
63MP0005167_abnormal_blood-brain_barrier1.26959181
64MP0002295_abnormal_pulmonary_circulatio1.26092908
65MP0001486_abnormal_startle_reflex1.25913431
66MP0003315_abnormal_perineum_morphology1.24693203
67MP0010386_abnormal_urinary_bladder1.23827303
68MP0005174_abnormal_tail_pigmentation1.23596444
69* MP0001963_abnormal_hearing_physiology1.22372445
70MP0005620_abnormal_muscle_contractility1.20817785
71MP0003828_pulmonary_edema1.20108602
72MP0004742_abnormal_vestibular_system1.17205600
73MP0005197_abnormal_uvea_morphology1.15565458
74MP0003937_abnormal_limbs/digits/tail_de1.13788318
75MP0009250_abnormal_appendicular_skeleto1.13703113
76* MP0000026_abnormal_inner_ear1.12158438
77MP0003303_peritoneal_inflammation1.10109908
78MP0002249_abnormal_larynx_morphology1.10035676
79MP0000920_abnormal_myelination1.10023868
80MP0004036_abnormal_muscle_relaxation1.09758100
81* MP0001756_abnormal_urination1.09157880
82MP0005503_abnormal_tendon_morphology1.08655606
83MP0004019_abnormal_vitamin_homeostasis1.07750380
84MP0000733_abnormal_muscle_development1.07300304
85MP0001502_abnormal_circadian_rhythm1.07266487
86MP0002933_joint_inflammation1.06477863
87MP0000579_abnormal_nail_morphology1.05350425
88MP0004233_abnormal_muscle_weight1.04268762
89MP0004782_abnormal_surfactant_physiolog1.03317265
90MP0002102_abnormal_ear_morphology1.02053156
91MP0003195_calcinosis1.01994537
92MP0005084_abnormal_gallbladder_morpholo1.01535451
93MP0002876_abnormal_thyroid_physiology0.99783475
94MP0004130_abnormal_muscle_cell0.99199912
95MP0008004_abnormal_stomach_pH0.98431365
96MP0005451_abnormal_body_composition0.96858655
97MP0005636_abnormal_mineral_homeostasis0.96674225
98MP0002972_abnormal_cardiac_muscle0.95702555
99MP0005551_abnormal_eye_electrophysiolog0.94233590
100MP0000015_abnormal_ear_pigmentation0.94019257
101MP0003091_abnormal_cell_migration0.93352962
102MP0001501_abnormal_sleep_pattern0.91235411
103MP0004215_abnormal_myocardial_fiber0.90084956
104MP0000163_abnormal_cartilage_morphology0.87348439
105MP0001346_abnormal_lacrimal_gland0.86651764
106MP0002752_abnormal_somatic_nervous0.86492509
107MP0000778_abnormal_nervous_system0.86402864
108MP0004085_abnormal_heartbeat0.85178414
109MP0002098_abnormal_vibrissa_morphology0.85028747
110MP0002168_other_aberrant_phenotype0.84951462
111MP0000003_abnormal_adipose_tissue0.83926109
112MP0000767_abnormal_smooth_muscle0.83075754
113MP0008260_abnormal_autophagy0.82625623
114MP0010030_abnormal_orbit_morphology0.82287240
115MP0005388_respiratory_system_phenotype0.82103722
116MP0002133_abnormal_respiratory_system0.82103722
117MP0010630_abnormal_cardiac_muscle0.81158547
118MP0001324_abnormal_eye_pigmentation0.80891571
119MP0000470_abnormal_stomach_morphology0.80072629
120MP0006138_congestive_heart_failure0.79629460
121MP0003137_abnormal_impulse_conducting0.78898923
122MP0002998_abnormal_bone_remodeling0.76757789
123MP0005195_abnormal_posterior_eye0.76688070
124* MP0005193_abnormal_anterior_eye0.73493761
125MP0001286_abnormal_eye_development0.73390853
126MP0004484_altered_response_of0.73152231
127MP0000762_abnormal_tongue_morphology0.72686038
128MP0000372_irregular_coat_pigmentation0.72420030
129MP0001664_abnormal_digestion0.72016328
130MP0003385_abnormal_body_wall0.71453884
131MP0001784_abnormal_fluid_regulation0.70742104
132MP0000613_abnormal_salivary_gland0.70555784
133MP0005266_abnormal_metabolism0.69888075
134MP0005381_digestive/alimentary_phenotyp0.69572880
135MP0002233_abnormal_nose_morphology0.69449871
136MP0001340_abnormal_eyelid_morphology0.67360895
137MP0000569_abnormal_digit_pigmentation0.65578286
138MP0001270_distended_abdomen0.65169660
139MP0002067_abnormal_sensory_capabilities0.63684598
140MP0002127_abnormal_cardiovascular_syste0.63595423
141MP0001919_abnormal_reproductive_system0.63512242
142MP0000462_abnormal_digestive_system0.63030520
143MP0000383_abnormal_hair_follicle0.62094807
144MP0009780_abnormal_chondrocyte_physiolo0.61474353
145MP0001299_abnormal_eye_distance/0.60892787
146MP0003300_gastrointestinal_ulcer0.58170335
147MP0001544_abnormal_cardiovascular_syste0.57867384
148MP0005385_cardiovascular_system_phenoty0.57867384
149MP0002971_abnormal_brown_adipose0.57753301
150MP0008961_abnormal_basal_metabolism0.57315163
151MP0005253_abnormal_eye_physiology0.57004028
152MP0001485_abnormal_pinna_reflex0.55056353
153MP0008775_abnormal_heart_ventricle0.53498967
154MP0000750_abnormal_muscle_regeneration0.53278114
155MP0005670_abnormal_white_adipose0.50074283
156MP0005375_adipose_tissue_phenotype0.49963985
157MP0003115_abnormal_respiratory_system0.49178099
158MP0005584_abnormal_enzyme/coenzyme_acti0.47680684
159MP0006036_abnormal_mitochondrial_physio0.47139164
160MP0005387_immune_system_phenotype0.47075667
161MP0001790_abnormal_immune_system0.47075667
162MP0003950_abnormal_plasma_membrane0.46581790
163MP0005275_abnormal_skin_tensile0.46343659

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)8.54121301
2Focal segmental glomerulosclerosis (HP:0000097)8.28448230
3Glomerulosclerosis (HP:0000096)6.72122309
4Muscle fiber inclusion bodies (HP:0100299)6.49118226
5Nemaline bodies (HP:0003798)6.47588292
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.24841046
7Hypoalbuminemia (HP:0003073)6.21806923
8Abnormal albumin level (HP:0012116)6.21806923
9Exercise-induced myalgia (HP:0003738)6.12631946
10Aplasia involving bones of the extremities (HP:0009825)6.07636367
11Aplasia involving bones of the upper limbs (HP:0009823)6.07636367
12Aplasia of the phalanges of the hand (HP:0009802)6.07636367
13Hypomagnesemia (HP:0002917)5.49167888
14* Stage 5 chronic kidney disease (HP:0003774)5.24485662
15Metabolic alkalosis (HP:0200114)5.21114224
16Hyperactive renin-angiotensin system (HP:0000841)5.12910121
17Hypokalemic alkalosis (HP:0001949)5.08985700
18Increased circulating renin level (HP:0000848)5.02236820
19Abnormality of magnesium homeostasis (HP:0004921)4.95968664
20Abnormality of chloride homeostasis (HP:0011422)4.85147246
21Partial duplication of thumb phalanx (HP:0009944)4.80597812
22Type 1 muscle fiber predominance (HP:0003803)4.78501623
23Partial duplication of the phalanx of hand (HP:0009999)4.60326755
24Alacrima (HP:0000522)4.43108805
25Abnormality of incisor morphology (HP:0011063)4.38747945
26Tubular atrophy (HP:0000092)4.26902680
27Conical tooth (HP:0000698)4.18469177
28Muscle hypertrophy of the lower extremities (HP:0008968)4.12437383
29Exercise-induced muscle cramps (HP:0003710)4.11929353
30Absent phalangeal crease (HP:0006109)4.10144351
31Abnormality of renin-angiotensin system (HP:0000847)4.02908630
32Recurrent corneal erosions (HP:0000495)4.00012001
33Metaphyseal dysplasia (HP:0100255)3.92979380
34Calf muscle hypertrophy (HP:0008981)3.83743592
35Decreased lacrimation (HP:0000633)3.73637415
36Polyuria (HP:0000103)3.71234195
37Hyperaldosteronism (HP:0000859)3.61902747
38Hypoproteinemia (HP:0003075)3.61262474
39* Nephrotic syndrome (HP:0000100)3.57425106
40Abnormal finger flexion creases (HP:0006143)3.50964659
41Abnormal urine output (HP:0012590)3.43654332
42Myoglobinuria (HP:0002913)3.35779419
43Distal arthrogryposis (HP:0005684)3.35656007
44Hyporeflexia of lower limbs (HP:0002600)3.32852006
45Polydipsia (HP:0001959)3.31234170
46Abnormal drinking behavior (HP:0030082)3.31234170
47Alkalosis (HP:0001948)3.31032560
48Tubulointerstitial fibrosis (HP:0005576)3.27478882
49Abnormality of renal excretion (HP:0011036)3.27372978
50Mixed hearing impairment (HP:0000410)3.26096135
51Corneal dystrophy (HP:0001131)3.23617000
52Neonatal respiratory distress (HP:0002643)3.23118062
53Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.19927024
54Myopathic facies (HP:0002058)3.19061133
55Renal salt wasting (HP:0000127)3.12328327
56Round ear (HP:0100830)3.12106050
57* Glomerulonephritis (HP:0000099)3.08163653
58Tetany (HP:0001281)3.05534569
59EMG: myopathic abnormalities (HP:0003458)3.04290893
60* Nephritis (HP:0000123)3.03567135
61Potter facies (HP:0002009)3.02356442
62Facial shape deformation (HP:0011334)3.02356442
63Abnormality of the salivary glands (HP:0010286)3.00386402
64* Proteinuria (HP:0000093)2.95151494
65Concave nail (HP:0001598)2.93268497
66Rhabdomyolysis (HP:0003201)2.92983454
67Difficulty running (HP:0009046)2.90464734
68Xerostomia (HP:0000217)2.86001210
69Muscle fiber splitting (HP:0003555)2.84194634
70Abnormality of the calf musculature (HP:0001430)2.82384899
71Anomalous pulmonary venous return (HP:0010772)2.78662432
72Aplasia of the musculature (HP:0100854)2.70952678
73Abnormality of the pulmonary veins (HP:0011718)2.70449934
74Abnormality of permanent molar morphology (HP:0011071)2.69766646
75Abnormality of the dental root (HP:0006486)2.69766646
76Taurodontia (HP:0000679)2.69766646
77Neck muscle weakness (HP:0000467)2.65564523
78Centrally nucleated skeletal muscle fibers (HP:0003687)2.55180029
79Abnormality of the dental pulp (HP:0006479)2.54784375
80Abnormality of molar morphology (HP:0011070)2.54513060
81Abnormality of molar (HP:0011077)2.54513060
82Hypokalemia (HP:0002900)2.49347629
83Hypercalciuria (HP:0002150)2.44988265
84Muscle stiffness (HP:0003552)2.44407103
85Broad hallux (HP:0010055)2.43862800
86Abnormality of the lacrimal duct (HP:0011481)2.41456626
87Abnormality of potassium homeostasis (HP:0011042)2.39853959
88Tubulointerstitial abnormality (HP:0001969)2.39207254
89Hypoparathyroidism (HP:0000829)2.38820692
90Frequent falls (HP:0002359)2.37247880
91Duplication of thumb phalanx (HP:0009942)2.33806951
92Abnormality of the nasolacrimal system (HP:0000614)2.32741214
93Abnormality of calcium-phosphate metabolism (HP:0100530)2.30995094
94Rapidly progressive (HP:0003678)2.30483461
95Asymmetric septal hypertrophy (HP:0001670)2.30255894
96Abnormal urine phosphate concentration (HP:0012599)2.29167689
97Increased connective tissue (HP:0009025)2.28935813
98* Hematuria (HP:0000790)2.28830115
99Delayed epiphyseal ossification (HP:0002663)2.28770277
100* Corneal erosion (HP:0200020)2.27035255
101Bundle branch block (HP:0011710)2.25301121
102Generalized muscle weakness (HP:0003324)2.23159564
103Hyperphosphaturia (HP:0003109)2.22011022
104Abnormality of skeletal muscle fiber size (HP:0012084)2.18009894
105Hypoplastic left heart (HP:0004383)2.17337237
106Increased corneal curvature (HP:0100692)2.12897236
107Keratoconus (HP:0000563)2.12897236
108Abnormality of the left ventricular outflow tract (HP:0011103)2.12490645
109Subaortic stenosis (HP:0001682)2.12490645
110Hypoplasia of the iris (HP:0007676)2.10200784
111Abnormality of the musculature of the hand (HP:0001421)2.09371140
112Thyroid-stimulating hormone excess (HP:0002925)2.08458127
113Ulnar deviation of the wrist (HP:0003049)2.08123063
114Ridged nail (HP:0001807)2.07571793
115Down-sloping shoulders (HP:0200021)2.04945054
116Hypoplasia of the ulna (HP:0003022)2.04044182
117Gastrointestinal stroma tumor (HP:0100723)2.03894907
118Abnormal hemoglobin (HP:0011902)2.03610928
119Ulnar claw (HP:0001178)2.01447858
120True hermaphroditism (HP:0010459)2.01238279
121Abnormality of the radial head (HP:0003995)2.00652293
122Seborrheic dermatitis (HP:0001051)2.00582675
123Hyponatremia (HP:0002902)2.00401490
124Synostosis involving the elbow (HP:0003938)1.99957874
125Humeroradial synostosis (HP:0003041)1.99957874
126Decreased circulating renin level (HP:0003351)1.98504349
127Increased variability in muscle fiber diameter (HP:0003557)1.97609649
128EMG: neuropathic changes (HP:0003445)1.94979181
129Knee flexion contracture (HP:0006380)1.94963682
130Myotonia (HP:0002486)1.94293688
131Gonadal dysgenesis (HP:0000133)1.94292095
132Abnormality of secondary sexual hair (HP:0009888)1.92864015
133Abnormality of the axillary hair (HP:0100134)1.92864015
134Areflexia of lower limbs (HP:0002522)1.92336638
135Broad toe (HP:0001837)1.91783515
136Hyperkalemia (HP:0002153)1.91057071
137Abnormality of sodium homeostasis (HP:0010931)1.90360118
138Sudden death (HP:0001699)1.89073598
139Bilateral sensorineural hearing impairment (HP:0008619)1.86592985
140Distal lower limb muscle weakness (HP:0009053)1.85500859
141Preaxial foot polydactyly (HP:0001841)1.85082204
142Abnormality of renal resorption (HP:0011038)1.84687485
143Hip contracture (HP:0003273)1.83403110
144Abnormal tarsal ossification (HP:0008369)1.82456729
145Mildly elevated creatine phosphokinase (HP:0008180)1.81172695
146Malignant hyperthermia (HP:0002047)1.79321900
147* Nonprogressive disorder (HP:0003680)1.78755612
148Vascular calcification (HP:0004934)1.78539870
149Type I transferrin isoform profile (HP:0003642)1.76683758
150Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76356313
151Parakeratosis (HP:0001036)1.72845350
152Limited hip movement (HP:0008800)1.72481769
153Hypothermia (HP:0002045)1.69990248
154Interstitial pulmonary disease (HP:0006530)1.69626322
155Adrenal overactivity (HP:0002717)1.69165657
156Pterygium (HP:0001059)1.68932465
157Optic disc pallor (HP:0000543)1.66222988
158Hypoplastic heart (HP:0001961)1.65661975
159Abnormality of Sharpey fibers (HP:0100685)1.63932051
160Attenuation of retinal blood vessels (HP:0007843)1.63092309
161Lymphangioma (HP:0100764)1.62259466
162Visceral angiomatosis (HP:0100761)1.60315150
163Reduced antithrombin III activity (HP:0001976)1.60015177
164Coronal craniosynostosis (HP:0004440)1.57116385
165Gout (HP:0001997)1.54812258
166Spontaneous hematomas (HP:0007420)1.54720150
167Abnormality of glutamine family amino acid metabolism (HP:0010902)1.53317654
168Peripheral hypomyelination (HP:0007182)1.52213898
169Dynein arm defect of respiratory motile cilia (HP:0012255)1.52171946
170Absent/shortened dynein arms (HP:0200106)1.52171946
171Hypertensive crisis (HP:0100735)1.51407838
172Nasolacrimal duct obstruction (HP:0000579)1.50696837
173Cardiovascular calcification (HP:0011915)1.49456801
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.48886944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.16048855
2OXSR14.89100887
3WNK44.77803828
4CASK4.35823383
5STK394.24326717
6TIE13.71444746
7LATS13.39983030
8TNIK3.39153824
9TTN3.31929894
10EPHB23.29711876
11PHKG23.20239910
12PHKG13.20239910
13TRPM72.88670968
14WNK32.57044304
15MUSK2.51814172
16TGFBR22.50456934
17MOS2.37184919
18MKNK22.29080149
19MYLK2.23879695
20MST42.22303189
21PRKD22.11251775
22STK38L1.99722015
23PINK11.99688905
24MAPK151.87439718
25FES1.84647138
26MAP3K131.82001293
27KDR1.80367053
28TLK11.59667377
29RIPK11.57399917
30EPHA31.54598309
31CDK191.53766675
32CLK11.49405235
33GRK11.47732569
34PIK3CG1.46225605
35WNK11.44001808
36LATS21.43806811
37PDK21.33720809
38NLK1.33065666
39MAPK71.32960146
40FER1.31037602
41SGK21.28380559
42FRK1.22559638
43NME21.18624232
44IRAK21.13854648
45MELK1.13370292
46RIPK41.10632730
47EPHB11.09061287
48TRIB31.07497505
49IRAK31.04341494
50MKNK11.02017281
51STK161.01153341
52PDPK11.01062010
53IRAK10.99572091
54KIT0.98578495
55PAK40.97956172
56FGFR20.95068895
57STK380.94057736
58DAPK20.93577512
59SGK30.89141749
60PDK10.86424394
61TEC0.85344885
62BLK0.81850513
63AKT20.81383460
64IRAK40.81227860
65NEK90.80986930
66YES10.80715854
67TGFBR10.79281148
68STK100.79091583
69CSK0.77777431
70TBK10.77031933
71NEK60.77013012
72RET0.76849108
73ADRBK20.76770638
74FGFR40.74835962
75FGR0.74565992
76HIPK20.74372367
77MAP3K60.74312043
78GRK70.73880714
79PKN10.72789150
80JAK10.70083915
81MST1R0.69887040
82GSK3A0.68627501
83CSNK1G10.67810179
84MAP2K30.67291345
85NME10.67289272
86ROCK10.66316159
87MAP3K30.66291431
88FGFR30.66048326
89INSRR0.63088326
90RPS6KL10.60106640
91RPS6KC10.60106640
92SYK0.59428315
93ICK0.58898113
94CDC42BPA0.58350811
95PRKCE0.58002113
96MAPK130.56995103
97SRPK10.56956903
98CDK30.55869426
99RPS6KA60.54800440
100EEF2K0.53419404
101STK110.53351149
102SIK10.52673445
103CAMK10.52280852
104PRKAA10.52187294
105MAPK110.52009800
106EIF2AK20.51865384
107PAK20.51344897
108TAOK30.50381456
109EIF2AK30.49029404
110MAPKAPK30.48448952
111SGK2230.47708505
112SGK4940.47708505
113MAPK120.47384701
114UHMK10.46805766
115ADRBK10.46664322
116STK30.46329003
117MAP2K10.46111945
118PRKD10.44158823
119MAP3K140.42568642
120MTOR0.42293702
121ABL20.41127906
122MAP2K60.41077280
123MAP3K70.40660703
124NTRK10.39915444
125MAPKAPK50.39797691
126ARAF0.39513383
127CSNK1A1L0.39435836
128GRK50.39105868
129TYK20.38911625
130MAP3K10.38896057
131MAPK30.37367585
132MAPK40.36770383
133MAP2K70.35913228
134PRPF4B0.35528081
135MARK20.34460761
136CAMKK20.33911252
137ROCK20.33789111
138ABL10.32957906
139JAK20.32452414
140CDK120.32082417
141CAMK2A0.32037051
142MAP3K120.31814686
143BMPR1B0.31508739
144SGK10.30933067
145MET0.30519237
146PRKG20.29642737
147* PRKACA0.28718876
148PBK0.28251987
149FYN0.26475764
150VRK10.26448797
151PRKAA20.24318055
152CSNK1G30.24226889
153IKBKE0.22765819
154RPS6KA50.22691149
155BMPR20.22371933
156TXK0.21112226
157MAP2K20.20710329
158PRKCQ0.20340961
159CAMK2G0.18673734
160AKT30.18367322
161IGF1R0.16747124
162PRKG10.16448729

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.60428434
2Circadian rhythm_Homo sapiens_hsa047103.96487219
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.19318492
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.00227925
5Renin-angiotensin system_Homo sapiens_hsa046142.94955667
6* ECM-receptor interaction_Homo sapiens_hsa045122.79257844
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.74326413
8Axon guidance_Homo sapiens_hsa043602.51387878
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39252307
10Sphingolipid metabolism_Homo sapiens_hsa006002.25067988
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20386727
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.15360794
13Phototransduction_Homo sapiens_hsa047441.95650239
14Other glycan degradation_Homo sapiens_hsa005111.94924176
15Tryptophan metabolism_Homo sapiens_hsa003801.94808950
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.86991810
17* Protein digestion and absorption_Homo sapiens_hsa049741.83910564
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67199796
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61746847
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57972751
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.50197824
22Lysine degradation_Homo sapiens_hsa003101.48952817
23Protein export_Homo sapiens_hsa030601.44162948
24Vitamin digestion and absorption_Homo sapiens_hsa049771.43636366
25Ether lipid metabolism_Homo sapiens_hsa005651.41728062
26Pentose phosphate pathway_Homo sapiens_hsa000301.39241416
27Fatty acid elongation_Homo sapiens_hsa000621.37991922
28Oxidative phosphorylation_Homo sapiens_hsa001901.32496082
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32200038
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31972275
31Arachidonic acid metabolism_Homo sapiens_hsa005901.31939360
32* Focal adhesion_Homo sapiens_hsa045101.28961735
33Glucagon signaling pathway_Homo sapiens_hsa049221.28694189
34Insulin resistance_Homo sapiens_hsa049311.27948722
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27646684
36Fatty acid degradation_Homo sapiens_hsa000711.24985036
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24572925
38Ribosome_Homo sapiens_hsa030101.23994549
39Melanoma_Homo sapiens_hsa052181.23750572
40Cardiac muscle contraction_Homo sapiens_hsa042601.19791922
41Bile secretion_Homo sapiens_hsa049761.15098223
42Fructose and mannose metabolism_Homo sapiens_hsa000511.11846689
43* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09974101
44Viral myocarditis_Homo sapiens_hsa054161.08613833
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.07717199
46Mineral absorption_Homo sapiens_hsa049781.07641096
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04633712
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02065626
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.01450481
50Nicotine addiction_Homo sapiens_hsa050331.01140961
51Arginine and proline metabolism_Homo sapiens_hsa003300.99541647
52Rheumatoid arthritis_Homo sapiens_hsa053230.98801697
53Autoimmune thyroid disease_Homo sapiens_hsa053200.97402550
54N-Glycan biosynthesis_Homo sapiens_hsa005100.97007135
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96704913
56Insulin signaling pathway_Homo sapiens_hsa049100.95700638
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94494656
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.94381487
59Asthma_Homo sapiens_hsa053100.94322899
60* Small cell lung cancer_Homo sapiens_hsa052220.94122869
61Renin secretion_Homo sapiens_hsa049240.93631012
62Taste transduction_Homo sapiens_hsa047420.93432062
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92578463
64Histidine metabolism_Homo sapiens_hsa003400.92335354
65Oxytocin signaling pathway_Homo sapiens_hsa049210.92038329
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91662494
67Serotonergic synapse_Homo sapiens_hsa047260.90159752
68Collecting duct acid secretion_Homo sapiens_hsa049660.89996734
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89209775
70Morphine addiction_Homo sapiens_hsa050320.88577989
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88370309
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88089902
73Pyruvate metabolism_Homo sapiens_hsa006200.87176095
74* Amoebiasis_Homo sapiens_hsa051460.86258871
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85802517
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85761142
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.82996424
78Allograft rejection_Homo sapiens_hsa053300.82987739
79* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82615917
80Gastric acid secretion_Homo sapiens_hsa049710.82167180
81Wnt signaling pathway_Homo sapiens_hsa043100.79385676
82Hematopoietic cell lineage_Homo sapiens_hsa046400.79127100
83Carbon metabolism_Homo sapiens_hsa012000.78797369
84Propanoate metabolism_Homo sapiens_hsa006400.78759562
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78315274
86Dilated cardiomyopathy_Homo sapiens_hsa054140.76442823
87Alzheimers disease_Homo sapiens_hsa050100.76259137
88Phenylalanine metabolism_Homo sapiens_hsa003600.76003258
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.75832056
90B cell receptor signaling pathway_Homo sapiens_hsa046620.75794144
91Rap1 signaling pathway_Homo sapiens_hsa040150.74385198
92Tight junction_Homo sapiens_hsa045300.72232028
93Long-term depression_Homo sapiens_hsa047300.71665289
94Dorso-ventral axis formation_Homo sapiens_hsa043200.71620991
95Ras signaling pathway_Homo sapiens_hsa040140.71339487
96Glutathione metabolism_Homo sapiens_hsa004800.70629699
97Renal cell carcinoma_Homo sapiens_hsa052110.70575916
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70130746
99Salivary secretion_Homo sapiens_hsa049700.69633697
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69434254
101MAPK signaling pathway_Homo sapiens_hsa040100.69290240
102Arginine biosynthesis_Homo sapiens_hsa002200.66322590
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66214195
104Sulfur metabolism_Homo sapiens_hsa009200.65743218
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65508363
106FoxO signaling pathway_Homo sapiens_hsa040680.61789023
107cAMP signaling pathway_Homo sapiens_hsa040240.61625782
108Adherens junction_Homo sapiens_hsa045200.61076121
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.60116861
110GnRH signaling pathway_Homo sapiens_hsa049120.59814113
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59306299
112Malaria_Homo sapiens_hsa051440.59206060
113Parkinsons disease_Homo sapiens_hsa050120.58466861
114Basal cell carcinoma_Homo sapiens_hsa052170.58309699
115ABC transporters_Homo sapiens_hsa020100.57771015
116Thyroid hormone synthesis_Homo sapiens_hsa049180.57484343
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56166961
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55477276
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55187993
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55096041
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54605231
122* Pathways in cancer_Homo sapiens_hsa052000.54488497
123TGF-beta signaling pathway_Homo sapiens_hsa043500.53158792
124Retinol metabolism_Homo sapiens_hsa008300.53123285
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52714910
126Butanoate metabolism_Homo sapiens_hsa006500.52676053
127Prostate cancer_Homo sapiens_hsa052150.52401008
128Graft-versus-host disease_Homo sapiens_hsa053320.52147402
129Choline metabolism in cancer_Homo sapiens_hsa052310.50600970
130Platelet activation_Homo sapiens_hsa046110.50346907
131Calcium signaling pathway_Homo sapiens_hsa040200.48316793
132Hedgehog signaling pathway_Homo sapiens_hsa043400.48258903
133Vitamin B6 metabolism_Homo sapiens_hsa007500.48206058
134HIF-1 signaling pathway_Homo sapiens_hsa040660.47652046
135Sulfur relay system_Homo sapiens_hsa041220.47584869
136Glutamatergic synapse_Homo sapiens_hsa047240.46594707
137AMPK signaling pathway_Homo sapiens_hsa041520.46131412
138Galactose metabolism_Homo sapiens_hsa000520.44481230
139Ovarian steroidogenesis_Homo sapiens_hsa049130.44044033
140Pancreatic secretion_Homo sapiens_hsa049720.43373837
141Insulin secretion_Homo sapiens_hsa049110.43093173
142beta-Alanine metabolism_Homo sapiens_hsa004100.42700030
143Staphylococcus aureus infection_Homo sapiens_hsa051500.42327286
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42171244
145GABAergic synapse_Homo sapiens_hsa047270.41911092
146Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41747317
147Melanogenesis_Homo sapiens_hsa049160.41571625
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41208327
149Starch and sucrose metabolism_Homo sapiens_hsa005000.39638330
150Type I diabetes mellitus_Homo sapiens_hsa049400.39108981
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38540452
152Phagosome_Homo sapiens_hsa041450.37231875
153Inositol phosphate metabolism_Homo sapiens_hsa005620.37020154
154Lysosome_Homo sapiens_hsa041420.36982805
155Gap junction_Homo sapiens_hsa045400.36188234
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.35578101
157Circadian entrainment_Homo sapiens_hsa047130.34261590
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32975091
159Fatty acid metabolism_Homo sapiens_hsa012120.32236265

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