COL4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Notch signaling involved in heart development (GO:0061314)7.00442235
2vascular endothelial growth factor signaling pathway (GO:0038084)5.48185545
3ventricular trabecula myocardium morphogenesis (GO:0003222)5.31659989
4* retina vasculature morphogenesis in camera-type eye (GO:0061299)4.80323804
5polarized epithelial cell differentiation (GO:0030859)4.74628679
6* basement membrane organization (GO:0071711)4.74109977
7protein heterotrimerization (GO:0070208)4.67190903
8endodermal cell differentiation (GO:0035987)4.65665539
9renal filtration (GO:0097205)4.58663861
10endothelial cell morphogenesis (GO:0001886)4.39434133
11negative regulation of blood vessel endothelial cell migration (GO:0043537)4.37589775
12cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.34771416
13glomerular filtration (GO:0003094)4.34249791
14heart valve formation (GO:0003188)4.31928569
15heart trabecula morphogenesis (GO:0061384)4.30702163
16lymph vessel development (GO:0001945)4.23158115
17regulation of vasculogenesis (GO:2001212)4.17533587
18blood vessel maturation (GO:0001955)4.10353270
19regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.08007797
20plasma membrane repair (GO:0001778)4.05230673
21endocardial cushion morphogenesis (GO:0003203)4.03748108
22collagen fibril organization (GO:0030199)4.03158419
23establishment of apical/basal cell polarity (GO:0035089)4.01566160
24trabecula morphogenesis (GO:0061383)4.01342387
25cell migration involved in sprouting angiogenesis (GO:0002042)3.96768209
26hemidesmosome assembly (GO:0031581)3.90723158
27lymphangiogenesis (GO:0001946)3.87087793
28glomerular basement membrane development (GO:0032836)3.86406094
29aorta morphogenesis (GO:0035909)3.80681302
30cell surface receptor signaling pathway involved in heart development (GO:0061311)3.77456758
31epithelial cell-cell adhesion (GO:0090136)3.77036787
32positive regulation of vasculogenesis (GO:2001214)3.74937099
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.74604203
34blood vessel endothelial cell migration (GO:0043534)3.72641750
35neuron projection extension involved in neuron projection guidance (GO:1902284)3.69727419
36axon extension involved in axon guidance (GO:0048846)3.69727419
37angiogenesis involved in wound healing (GO:0060055)3.66128043
38epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.64991853
39cell adhesion mediated by integrin (GO:0033627)3.62388796
40* collagen metabolic process (GO:0032963)3.60663347
41chondrocyte proliferation (GO:0035988)3.60225396
42wound healing, spreading of epidermal cells (GO:0035313)3.58527471
43hippo signaling (GO:0035329)3.56245158
44cell-substrate junction assembly (GO:0007044)3.55021753
45* multicellular organismal macromolecule metabolic process (GO:0044259)3.44393105
46* collagen catabolic process (GO:0030574)3.43767673
47cardiac myofibril assembly (GO:0055003)3.40315865
48positive regulation of endothelial cell apoptotic process (GO:2000353)3.39164938
49ovulation from ovarian follicle (GO:0001542)3.36931168
50embryonic foregut morphogenesis (GO:0048617)3.36758552
51negative regulation of endothelial cell migration (GO:0010596)3.36671103
52establishment of monopolar cell polarity (GO:0061162)3.35688016
53establishment or maintenance of monopolar cell polarity (GO:0061339)3.35688016
54substrate adhesion-dependent cell spreading (GO:0034446)3.34054106
55* extracellular matrix disassembly (GO:0022617)3.32857360
56branching involved in salivary gland morphogenesis (GO:0060445)3.32142253
57vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.26780936
58atrioventricular valve morphogenesis (GO:0003181)3.26707232
59adherens junction assembly (GO:0034333)3.26660838
60* multicellular organismal metabolic process (GO:0044236)3.25814263
61mesenchyme morphogenesis (GO:0072132)3.25278966
62negative regulation of chondrocyte differentiation (GO:0032331)3.24829677
63endothelium development (GO:0003158)3.24068770
64paraxial mesoderm development (GO:0048339)3.22442976
65apoptotic cell clearance (GO:0043277)3.20065278
66* multicellular organismal catabolic process (GO:0044243)3.19766720
67regulation of cardioblast differentiation (GO:0051890)3.18812906
68regulation of hippo signaling (GO:0035330)3.17346036
69regulation of blood vessel endothelial cell migration (GO:0043535)3.13749059
70stress fiber assembly (GO:0043149)3.12218172
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11220419
72* patterning of blood vessels (GO:0001569)3.10939334
73morphogenesis of an endothelium (GO:0003159)3.09849851
74endothelial tube morphogenesis (GO:0061154)3.09849851
75regulation of SMAD protein import into nucleus (GO:0060390)3.09692852
76heart trabecula formation (GO:0060347)3.09654684
77positive regulation of endothelial cell migration (GO:0010595)3.07352340
78artery morphogenesis (GO:0048844)3.07029940
79neuron remodeling (GO:0016322)3.07002078
80endothelial cell migration (GO:0043542)3.06754854
81cardiac epithelial to mesenchymal transition (GO:0060317)3.06651474
82regulation of endothelial cell differentiation (GO:0045601)3.05875970
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.05301237
84extracellular fibril organization (GO:0043206)3.04951328
85endocardial cushion development (GO:0003197)3.03545920
86low-density lipoprotein particle clearance (GO:0034383)3.01411035
87insulin-like growth factor receptor signaling pathway (GO:0048009)3.01351934
88skin morphogenesis (GO:0043589)2.98746660
89* blood vessel morphogenesis (GO:0048514)2.97831152
90coronary vasculature morphogenesis (GO:0060977)2.97452823
91negative regulation of cell fate specification (GO:0009996)2.93926031
92sequestering of extracellular ligand from receptor (GO:0035581)2.91711371
93gap junction assembly (GO:0016264)2.91168492
94regulation of endothelial cell migration (GO:0010594)2.89936781
95kidney mesenchyme development (GO:0072074)2.89238520
96cell migration involved in heart development (GO:0060973)2.87153028
97regulation of tight junction assembly (GO:2000810)2.87104129
98mesodermal cell differentiation (GO:0048333)2.85851234
99renal system development (GO:0072001)2.85657055
100trabecula formation (GO:0060343)2.85502854
101angiogenesis (GO:0001525)2.85222868
102mRNA transcription (GO:0009299)2.85119653
103regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.84954622
104chondrocyte development (GO:0002063)2.84943442
105morphogenesis of an epithelial sheet (GO:0002011)2.84703782
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.83763889
107vasculogenesis (GO:0001570)2.82611995
108negative regulation of angiogenesis (GO:0016525)2.82227253
109focal adhesion assembly (GO:0048041)2.79049525
110cell-substrate adherens junction assembly (GO:0007045)2.79049525
111Notch receptor processing (GO:0007220)2.78855220
112blood vessel remodeling (GO:0001974)2.78708598
113cardiac ventricle morphogenesis (GO:0003208)2.76351288
114bone trabecula formation (GO:0060346)2.76295644
115peptidyl-proline hydroxylation (GO:0019511)2.75100087
116heart valve morphogenesis (GO:0003179)2.74959981
117regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.72390923
118positive regulation of odontogenesis (GO:0042482)2.72199012
119endothelial cell proliferation (GO:0001935)2.71928113
120wound healing, spreading of cells (GO:0044319)2.71728954
121cardiac chamber morphogenesis (GO:0003206)2.70839371
122regulation of p38MAPK cascade (GO:1900744)2.70753685
123embryonic heart tube development (GO:0035050)2.70551817
124negative regulation of blood vessel morphogenesis (GO:2000181)2.70476896
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69886071
126positive regulation of SMAD protein import into nucleus (GO:0060391)2.69670994
127protein localization to cell surface (GO:0034394)2.68713351
128chemical homeostasis within a tissue (GO:0048875)2.68336752
129establishment of epithelial cell polarity (GO:0090162)2.66811970
130bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66265065
131regulation of cell fate specification (GO:0042659)2.65480463
132mRNA transcription from RNA polymerase II promoter (GO:0042789)2.64479787
133protein hydroxylation (GO:0018126)2.64158209
134substrate-dependent cell migration (GO:0006929)2.64146550
135positive regulation of p38MAPK cascade (GO:1900745)2.63627845
136endothelial cell chemotaxis (GO:0035767)2.62515102
137protein localization to endosome (GO:0036010)2.62447832
138surfactant homeostasis (GO:0043129)2.62146939
139venous blood vessel morphogenesis (GO:0048845)2.60982314
140endothelial cell differentiation (GO:0045446)2.60858385
141cell-substrate adhesion (GO:0031589)2.60385624
142sprouting angiogenesis (GO:0002040)2.59398623
143semaphorin-plexin signaling pathway (GO:0071526)2.57752717
144myofibril assembly (GO:0030239)2.56518587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.40860778
2* TRIM28_21343339_ChIP-Seq_HEK293_Human4.58565107
3* CLOCK_20551151_ChIP-Seq_293T_Human3.77225680
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.72213381
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.52429424
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15952802
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.49698766
8* EP300_21415370_ChIP-Seq_HL-1_Mouse2.46509639
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.43733531
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.42618514
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.33386837
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.30402032
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.23391397
14RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.18083905
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.15495449
16GATA2_21666600_ChIP-Seq_HMVEC_Human2.08804964
17ZNF263_19887448_ChIP-Seq_K562_Human2.08176643
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.00930993
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00329744
20* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.99989072
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98817790
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96437133
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92527812
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91087370
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85613483
26TBX20_22328084_ChIP-Seq_HEART_Mouse1.83125084
27TBX20_22080862_ChIP-Seq_HEART_Mouse1.83125084
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82039381
29CJUN_26792858_Chip-Seq_BT549_Human1.78525512
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.78063943
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77193814
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77082626
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.75888688
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71060596
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67938223
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65977143
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62669140
38* BRD4_25478319_ChIP-Seq_HGPS_Human1.61824122
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59580814
40* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57807236
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.56084911
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53880992
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52134462
44* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51189082
45RACK7_27058665_Chip-Seq_MCF-7_Human1.49851648
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49715431
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49213085
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.44567852
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44183337
50* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44183337
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44070589
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44070589
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44070589
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42938979
55* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42283131
56KDM2B_26808549_Chip-Seq_K562_Human1.42141886
57* UBF1/2_26484160_Chip-Seq_HMECs_Human1.41586784
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40741784
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40706455
60* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37357073
61* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35945927
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.35933679
63KDM2B_26808549_Chip-Seq_DND41_Human1.35910334
64TP53_18474530_ChIP-ChIP_U2OS_Human1.35462225
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34879026
66ATF3_27146783_Chip-Seq_COLON_Human1.34449492
67* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33762057
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.33672474
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33570550
70* TP53_20018659_ChIP-ChIP_R1E_Mouse1.32512422
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31606137
72* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31534468
73* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.31391912
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.31007515
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28621116
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28383441
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28030674
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26137832
79* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25395166
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23117681
81TP53_22127205_ChIP-Seq_IMR90_Human1.23018981
82* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22719972
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21640847
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20952795
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20718914
86LXR_22292898_ChIP-Seq_THP-1_Human1.20524381
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.20163037
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18180505
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.17109223
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16992274
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14391624
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.13485080
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12847444
94* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12218927
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09657547
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09395959
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09157611
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08838039
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.08733281
100* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08525173
101* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08286931
102SA1_22415368_ChIP-Seq_MEFs_Mouse1.07953406
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07813769
104SOX2_20726797_ChIP-Seq_SW620_Human1.07128929
105SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06706271
106* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03326666
107* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03190714
108* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02472314
109* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02138965
110* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02138965
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.00105207
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.99562847
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99471794
114TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98114091
115TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97906220
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97798130
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97725327
118GATA1_19941826_ChIP-Seq_K562_Human0.97461612
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.97449350
120* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96870438
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96573683
122* EED_16625203_ChIP-ChIP_MESCs_Mouse0.96485225
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96422024
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.95835804
125* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95306490
126* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95306490
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94030683
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93518303
129AHR_22903824_ChIP-Seq_MCF-7_Human0.93250330
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91947715
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.91762055
132* TP53_16413492_ChIP-PET_HCT116_Human0.91469802
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88375472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004272_abnormal_basement_membrane6.01975994
2MP0008438_abnormal_cutaneous_collagen5.42532615
3MP0010368_abnormal_lymphatic_system4.31463178
4MP0005623_abnormal_meninges_morphology3.66507736
5MP0003705_abnormal_hypodermis_morpholog3.61012908
6MP0005275_abnormal_skin_tensile3.32127505
7MP0001879_abnormal_lymphatic_vessel2.89729568
8MP0003279_aneurysm2.89329918
9MP0001958_emphysema2.56322270
10MP0004084_abnormal_cardiac_muscle2.50308527
11MP0005503_abnormal_tendon_morphology2.46811637
12MP0003566_abnormal_cell_adhesion2.38984484
13MP0006054_spinal_hemorrhage2.37347439
14MP0000751_myopathy2.23517879
15MP0003941_abnormal_skin_development2.02190060
16MP0005167_abnormal_blood-brain_barrier1.87516168
17MP0003828_pulmonary_edema1.84447828
18MP0006138_congestive_heart_failure1.76419893
19MP0000767_abnormal_smooth_muscle1.70488167
20MP0000013_abnormal_adipose_tissue1.68942563
21MP0003091_abnormal_cell_migration1.64047756
22MP0000465_gastrointestinal_hemorrhage1.55587366
23MP0003385_abnormal_body_wall1.51591597
24MP0000750_abnormal_muscle_regeneration1.46811296
25MP0000733_abnormal_muscle_development1.42473978
26MP0009384_cardiac_valve_regurgitation1.42277677
27MP0000537_abnormal_urethra_morphology1.41407719
28MP0010352_gastrointestinal_tract_polyps1.37293811
29MP0002295_abnormal_pulmonary_circulatio1.36440371
30MP0005330_cardiomyopathy1.34390069
31MP0004036_abnormal_muscle_relaxation1.33007083
32MP0008775_abnormal_heart_ventricle1.31870379
33MP0005508_abnormal_skeleton_morphology1.27606821
34MP0002837_dystrophic_cardiac_calcinosis1.27552068
35MP0004087_abnormal_muscle_fiber1.26994107
36MP0010630_abnormal_cardiac_muscle1.26343779
37MP0005023_abnormal_wound_healing1.24425582
38MP0002060_abnormal_skin_morphology1.21876434
39* MP0002128_abnormal_blood_circulation1.20374651
40MP0003115_abnormal_respiratory_system1.20259657
41MP0000003_abnormal_adipose_tissue1.19943966
42MP0005385_cardiovascular_system_phenoty1.19892072
43MP0001544_abnormal_cardiovascular_syste1.19892072
44MP0000534_abnormal_ureter_morphology1.19157268
45MP0003045_fibrosis1.18661082
46* MP0002925_abnormal_cardiovascular_devel1.17709720
47MP0004215_abnormal_myocardial_fiber1.16795390
48* MP0001614_abnormal_blood_vessel1.16110258
49MP0001849_ear_inflammation1.15295908
50MP0003567_abnormal_fetal_cardiomyocyte1.14876697
51MP0005670_abnormal_white_adipose1.13430081
52MP0002896_abnormal_bone_mineralization1.12904127
53MP0004185_abnormal_adipocyte_glucose1.12324332
54MP0010234_abnormal_vibrissa_follicle1.11925995
55MP0000749_muscle_degeneration1.11771631
56MP0003283_abnormal_digestive_organ1.11687353
57MP0002108_abnormal_muscle_morphology1.11420717
58MP0005375_adipose_tissue_phenotype1.06237357
59MP0003950_abnormal_plasma_membrane1.05882266
60MP0005409_darkened_coat_color1.05021709
61MP0002877_abnormal_melanocyte_morpholog1.04545604
62MP0003122_maternal_imprinting1.04392036
63MP0004130_abnormal_muscle_cell1.03633155
64MP0005666_abnormal_adipose_tissue1.03104264
65MP0001542_abnormal_bone_strength1.02597361
66MP0002972_abnormal_cardiac_muscle1.01063176
67MP0004858_abnormal_nervous_system0.99761134
68MP0010030_abnormal_orbit_morphology0.99307414
69MP0005595_abnormal_vascular_smooth0.96881281
70MP0005187_abnormal_penis_morphology0.93914557
71MP0009278_abnormal_bone_marrow0.93569487
72* MP0000266_abnormal_heart_morphology0.93504345
73MP0000762_abnormal_tongue_morphology0.93348647
74* MP0001915_intracranial_hemorrhage0.93252528
75MP0009053_abnormal_anal_canal0.93024586
76MP0005620_abnormal_muscle_contractility0.92924898
77MP0005076_abnormal_cell_differentiation0.92008107
78MP0001299_abnormal_eye_distance/0.91960953
79* MP0002697_abnormal_eye_size0.91772655
80MP0005165_increased_susceptibility_to0.91750661
81MP0002127_abnormal_cardiovascular_syste0.90911634
82MP0000462_abnormal_digestive_system0.86598396
83MP0003300_gastrointestinal_ulcer0.86181967
84MP0003935_abnormal_craniofacial_develop0.85358448
85MP0003942_abnormal_urinary_system0.85088808
86* MP0002086_abnormal_extraembryonic_tissu0.84393647
87MP0005257_abnormal_intraocular_pressure0.84046049
88MP0000428_abnormal_craniofacial_morphol0.80832488
89MP0000759_abnormal_skeletal_muscle0.80577213
90MP0003119_abnormal_digestive_system0.80338995
91MP0002168_other_aberrant_phenotype0.80078710
92MP0009250_abnormal_appendicular_skeleto0.79838271
93MP0005164_abnormal_response_to0.78805018
94* MP0005193_abnormal_anterior_eye0.78377077
95MP0000343_altered_response_to0.78342575
96MP0002106_abnormal_muscle_physiology0.77594066
97MP0002933_joint_inflammation0.77357031
98MP0004197_abnormal_fetal_growth/weight/0.76699243
99MP0002932_abnormal_joint_morphology0.75089453
100MP0001243_abnormal_dermal_layer0.75064161
101MP0005369_muscle_phenotype0.75038811
102* MP0003984_embryonic_growth_retardation0.74338130
103MP0005388_respiratory_system_phenotype0.74181451
104* MP0002088_abnormal_embryonic_growth/wei0.73588487
105MP0000516_abnormal_urinary_system0.72221936
106MP0005367_renal/urinary_system_phenotyp0.72221936
107MP0000249_abnormal_blood_vessel0.71704876
108MP0009780_abnormal_chondrocyte_physiolo0.71335103
109MP0001175_abnormal_lung_morphology0.70406280
110MP0002269_muscular_atrophy0.69075057
111MP0000049_abnormal_middle_ear0.68813562
112MP0004484_altered_response_of0.68447353
113* MP0001784_abnormal_fluid_regulation0.68055902
114MP0004145_abnormal_muscle_electrophysio0.67959674
115MP0002133_abnormal_respiratory_system0.67853711
116MP0003448_altered_tumor_morphology0.65553910
117MP0003755_abnormal_palate_morphology0.61036813
118* MP0005197_abnormal_uvea_morphology0.59389913
119MP0000747_muscle_weakness0.56820207
120MP0005390_skeleton_phenotype0.56247838
121MP0000163_abnormal_cartilage_morphology0.52640900
122MP0000432_abnormal_head_morphology0.52535346

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.61295792
2Premature rupture of membranes (HP:0001788)6.20193001
3Shallow orbits (HP:0000586)4.61261141
4Ankle contracture (HP:0006466)4.60901612
5* Cerebral aneurysm (HP:0004944)4.51254531
6Broad metatarsal (HP:0001783)4.25722228
7Increased connective tissue (HP:0009025)4.13768963
8Aortic dissection (HP:0002647)4.12615914
9Atrophic scars (HP:0001075)3.90822860
10Bladder diverticulum (HP:0000015)3.66911371
11Aortic aneurysm (HP:0004942)3.40107012
12Type 1 muscle fiber predominance (HP:0003803)3.39605780
13Spinal rigidity (HP:0003306)3.37543375
14Fragile skin (HP:0001030)3.28066708
15Soft skin (HP:0000977)3.27663720
16Muscle fiber splitting (HP:0003555)3.20601489
17Mitral valve prolapse (HP:0001634)3.18200414
18Lymphangioma (HP:0100764)3.10597199
19Increased variability in muscle fiber diameter (HP:0003557)3.09731395
20Wrist flexion contracture (HP:0001239)2.97478811
21Follicular hyperkeratosis (HP:0007502)2.94491506
22Dilatation of the ascending aorta (HP:0005111)2.87423986
23Peritonitis (HP:0002586)2.83079851
24Abnormality of skeletal muscle fiber size (HP:0012084)2.79532957
25Cervical subluxation (HP:0003308)2.78123407
26* Aneurysm (HP:0002617)2.76268740
27Abnormality of dentin (HP:0010299)2.76244227
28Asymmetry of the thorax (HP:0001555)2.70667660
29Mildly elevated creatine phosphokinase (HP:0008180)2.69332764
30Hyporeflexia of lower limbs (HP:0002600)2.64287481
31Blue sclerae (HP:0000592)2.63114958
32Wormian bones (HP:0002645)2.62377701
33Right ventricular cardiomyopathy (HP:0011663)2.55264413
34Short 4th metacarpal (HP:0010044)2.54017023
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54017023
36Difficulty climbing stairs (HP:0003551)2.50304601
37Genu recurvatum (HP:0002816)2.48975245
38Hematochezia (HP:0002573)2.47743274
39Vertebral arch anomaly (HP:0008438)2.46334264
40Spondylolisthesis (HP:0003302)2.45846253
41Overgrowth (HP:0001548)2.40604279
42Disproportionate tall stature (HP:0001519)2.31199376
43Difficulty running (HP:0009046)2.29939900
44Bowel diverticulosis (HP:0005222)2.27423655
45Buphthalmos (HP:0000557)2.26470469
46Venous abnormality (HP:0002624)2.26329389
47Nonimmune hydrops fetalis (HP:0001790)2.24120964
48Venous insufficiency (HP:0005293)2.23663853
49Aortic regurgitation (HP:0001659)2.18952893
50Hyperextensible skin (HP:0000974)2.18867812
51Vitreoretinal degeneration (HP:0000655)2.18561313
52Joint laxity (HP:0001388)2.17645884
53Sudden death (HP:0001699)2.16990284
54Ventricular tachycardia (HP:0004756)2.15836735
55Abnormality of the 4th metacarpal (HP:0010012)2.13790901
56Capillary hemangiomas (HP:0005306)2.13423522
57Vascular tortuosity (HP:0004948)2.12576821
58Thin bony cortex (HP:0002753)2.12551127
59Limited hip movement (HP:0008800)2.11604458
60Neonatal short-limb short stature (HP:0008921)2.10402715
61Lipoatrophy (HP:0100578)2.09246025
62Infantile muscular hypotonia (HP:0008947)2.08800153
63Round ear (HP:0100830)2.08231007
64Rectal prolapse (HP:0002035)2.06549471
65Wide anterior fontanel (HP:0000260)2.06462815
66Polycythemia (HP:0001901)2.05935215
67Ectopia lentis (HP:0001083)2.05448060
68Bronchomalacia (HP:0002780)2.04632622
69Slender build (HP:0001533)2.03711523
70Abnormality of the ischium (HP:0003174)2.02857524
71Radial bowing (HP:0002986)2.02428380
72Scapular winging (HP:0003691)2.02195081
73Osteoarthritis (HP:0002758)1.99697753
74Mitral stenosis (HP:0001718)1.99092430
75Camptodactyly of toe (HP:0001836)1.98402247
76Short hallux (HP:0010109)1.98241688
77Vertebral compression fractures (HP:0002953)1.92930742
78Ulnar bowing (HP:0003031)1.92816457
79Hip contracture (HP:0003273)1.92525851
80Elbow flexion contracture (HP:0002987)1.91773118
81Thin ribs (HP:0000883)1.89889155
82Skull defect (HP:0001362)1.89682775
83Abnormality of the peritoneum (HP:0002585)1.89645983
84Biconcave vertebral bodies (HP:0004586)1.89373096
85Aortic valve stenosis (HP:0001650)1.89305372
86Arterial tortuosity (HP:0005116)1.88954454
87Anterior segment dysgenesis (HP:0007700)1.88599817
88Broad ribs (HP:0000885)1.88585917
89Inguinal hernia (HP:0000023)1.88047669
90Upper limb amyotrophy (HP:0009129)1.87792995
91Distal upper limb amyotrophy (HP:0007149)1.87792995
92* Hemiplegia (HP:0002301)1.84787779
93Aplasia/Hypoplasia of the hallux (HP:0008362)1.82997674
94Mitral regurgitation (HP:0001653)1.82989227
95Back pain (HP:0003418)1.81699401
96Knee flexion contracture (HP:0006380)1.81668160
97Breech presentation (HP:0001623)1.80673668
98Abnormal delivery (HP:0001787)1.80488583
99Deviation of the hallux (HP:0010051)1.80296447
100Abnormality of the anterior chamber (HP:0000593)1.79943456
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.79590921
102Osteolytic defects of the hand bones (HP:0009699)1.79590921
103Striae distensae (HP:0001065)1.79439877
104Abnormality of the acetabulum (HP:0003170)1.79191704
105Short nail (HP:0001799)1.78018646
106Enlarged penis (HP:0000040)1.77493330
107Thin skin (HP:0000963)1.77472112
108Esophageal varix (HP:0002040)1.77021813
109Mesangial abnormality (HP:0001966)1.76187421
110Congenital hip dislocation (HP:0001374)1.74514974
111Bowed forearm bones (HP:0003956)1.74504208
112Bowing of the arm (HP:0006488)1.74504208
113Subacute progressive viral hepatitis (HP:0006572)1.73297599
114Protruding ear (HP:0000411)1.73198203
115Thoracolumbar scoliosis (HP:0002944)1.72515854
116Lumbar hyperlordosis (HP:0002938)1.72345634
117Pulmonary artery stenosis (HP:0004415)1.72324186
118Hallux valgus (HP:0001822)1.72230650
119Atrial fibrillation (HP:0005110)1.71304963
120Coxa vara (HP:0002812)1.71147965
121Myocardial infarction (HP:0001658)1.70668147
122Joint contractures involving the joints of the feet (HP:0100492)1.68778318
123Flexion contracture of toe (HP:0005830)1.68778318
124Distal arthrogryposis (HP:0005684)1.68515857
125Visceral angiomatosis (HP:0100761)1.67964700
126Tibial bowing (HP:0002982)1.67896587
127* Hypoplasia of the iris (HP:0007676)1.66721040
128Platyspondyly (HP:0000926)1.66701363
129Increased mean platelet volume (HP:0011877)1.66547075
130* Porencephaly (HP:0002132)1.66489076
131High pitched voice (HP:0001620)1.66391684
132Mild short stature (HP:0003502)1.65412830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.43900465
2TRIB33.97395724
3KDR3.59733772
4TTN3.47120437
5PDGFRA3.17759914
6RIPK12.98836047
7PKN22.91320777
8EPHB22.51766001
9TGFBR22.41756773
10DDR22.09837310
11LATS12.08015230
12PTK61.92850897
13TGFBR11.92155297
14FER1.87563700
15DMPK1.80496118
16PTK2B1.78808183
17MYLK1.74396690
18ERN11.70461185
19EPHA21.67049324
20LATS21.62391206
21PTK21.62151002
22PAK41.59718161
23PAK21.56523771
24SIK11.53831815
25LRRK21.26878143
26MAP3K101.24078348
27PAK31.20222309
28PDGFRB1.17691340
29FES1.14699540
30EPHB11.14341290
31MET1.14197779
32BMX1.11014462
33FGFR41.07944635
34CAMK1D1.07667637
35PRKG21.04227240
36MTOR1.03747012
37PIK3CG1.03600059
38CAMK1G1.02682642
39PRKD31.02258223
40ARAF1.01660587
41LMTK21.00655926
42FGFR10.95536099
43FGFR20.94479027
44ILK0.94416399
45ERBB40.93146744
46MAP2K10.90794723
47ROCK10.89475882
48PRKD10.89189523
49MAP2K20.85654590
50MAP3K30.81223368
51MAP3K130.80457643
52TRPM70.80131472
53STK30.78595870
54EEF2K0.78540032
55MAPK70.78340254
56TYRO30.77854233
57MAPKAPK30.77017009
58DAPK30.71495416
59SCYL20.66329290
60RET0.65586153
61STK100.64465639
62YES10.62911900
63MAP2K30.62407162
64PNCK0.61624544
65STK38L0.59398923
66ICK0.58748598
67RPS6KB20.57715510
68MAPK120.57376329
69FGFR30.57017269
70PDK20.56973708
71PRKCH0.56569379
72KSR20.56405372
73CDC42BPA0.55494287
74PIK3CA0.55301336
75GSK3A0.52988915
76ROCK20.52401175
77FLT30.51415586
78INSR0.49413117
79PRKAA20.48155025
80PDK30.45752899
81PDK40.45752899
82EPHA30.45329915
83CDK60.44722807
84NEK20.44690660
85SRC0.44223304
86TESK10.44094966
87ABL20.43924023
88STK240.43145013
89STK380.42966718
90ZAP700.42098044
91MAP3K80.41582741
92NEK90.41499496
93MAP3K60.40690178
94KSR10.39647593
95MOS0.39576807
96KIT0.38945135
97CDK120.38734555
98CLK10.38719286
99RPS6KA40.35326881
100NTRK10.35304683
101PRKD20.35193073
102MAPK40.33223633
103IGF1R0.33189378
104CSK0.33158499
105NEK10.33145389
106MAP3K90.32258942
107CDK40.32177906
108TAF10.30578700
109LIMK10.28728824
110STK390.28076204
111EGFR0.28041026
112PAK10.27836327
113DYRK1B0.27491755
114ALK0.27326480
115AKT20.26624658
116MARK20.25834212
117MAP3K70.25705447
118RPS6KA20.24926277
119PRKCE0.24309461
120AKT30.23820409
121FRK0.23513113
122MAP3K120.23115628
123ADRBK10.22925409
124MAPK10.22336108
125PLK20.22242656
126OBSCN0.21949683
127SMG10.21568076
128CDK90.18378484

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045124.70873412
2* Focal adhesion_Homo sapiens_hsa045103.36658017
3* Small cell lung cancer_Homo sapiens_hsa052222.80551618
4* Amoebiasis_Homo sapiens_hsa051462.59438089
5Dilated cardiomyopathy_Homo sapiens_hsa054142.45871369
6* Protein digestion and absorption_Homo sapiens_hsa049742.45563997
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.38039746
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.34772926
9Adherens junction_Homo sapiens_hsa045202.31971855
10* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.15970902
11Proteoglycans in cancer_Homo sapiens_hsa052052.13733897
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.84306490
13Hippo signaling pathway_Homo sapiens_hsa043901.77591128
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.70679210
15Tight junction_Homo sapiens_hsa045301.67448706
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.66690180
17* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.65171444
18Basal cell carcinoma_Homo sapiens_hsa052171.54414317
19Viral myocarditis_Homo sapiens_hsa054161.54286826
20Bladder cancer_Homo sapiens_hsa052191.53320470
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50675075
22TGF-beta signaling pathway_Homo sapiens_hsa043501.49606052
23MicroRNAs in cancer_Homo sapiens_hsa052061.45022926
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39314618
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.35481285
26Notch signaling pathway_Homo sapiens_hsa043301.33744784
27Toxoplasmosis_Homo sapiens_hsa051451.31393433
28Hedgehog signaling pathway_Homo sapiens_hsa043401.30654511
29Rap1 signaling pathway_Homo sapiens_hsa040151.29723377
30* Pathways in cancer_Homo sapiens_hsa052001.27876198
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26716798
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19284539
33Dorso-ventral axis formation_Homo sapiens_hsa043201.17098149
34Chronic myeloid leukemia_Homo sapiens_hsa052201.16384689
35Platelet activation_Homo sapiens_hsa046111.15117056
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.05363725
37Insulin resistance_Homo sapiens_hsa049311.04968658
38Axon guidance_Homo sapiens_hsa043601.04750857
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99367680
40PPAR signaling pathway_Homo sapiens_hsa033200.98542819
41Lysine degradation_Homo sapiens_hsa003100.97427519
42Melanoma_Homo sapiens_hsa052180.96159729
43Malaria_Homo sapiens_hsa051440.94693780
44Adipocytokine signaling pathway_Homo sapiens_hsa049200.90072603
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89514763
46VEGF signaling pathway_Homo sapiens_hsa043700.88955213
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.88643757
48Renal cell carcinoma_Homo sapiens_hsa052110.87818399
49Estrogen signaling pathway_Homo sapiens_hsa049150.86836036
50HIF-1 signaling pathway_Homo sapiens_hsa040660.85845312
51Nitrogen metabolism_Homo sapiens_hsa009100.85787094
52Prostate cancer_Homo sapiens_hsa052150.84935450
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84412824
54Glioma_Homo sapiens_hsa052140.84360049
55AMPK signaling pathway_Homo sapiens_hsa041520.83264898
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81973074
57Melanogenesis_Homo sapiens_hsa049160.77776986
58Gap junction_Homo sapiens_hsa045400.76181103
59HTLV-I infection_Homo sapiens_hsa051660.75919502
60Thyroid cancer_Homo sapiens_hsa052160.75141948
61Pancreatic cancer_Homo sapiens_hsa052120.74945908
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73408656
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72912322
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72487947
65Endometrial cancer_Homo sapiens_hsa052130.70632555
66Prion diseases_Homo sapiens_hsa050200.70591071
67Wnt signaling pathway_Homo sapiens_hsa043100.70227048
68Fatty acid degradation_Homo sapiens_hsa000710.64870291
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64616129
70Ovarian steroidogenesis_Homo sapiens_hsa049130.61919638
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.61075689
72Endocytosis_Homo sapiens_hsa041440.60826333
73Ras signaling pathway_Homo sapiens_hsa040140.60742263
74Insulin signaling pathway_Homo sapiens_hsa049100.60658107
75Fatty acid metabolism_Homo sapiens_hsa012120.60614761
76Colorectal cancer_Homo sapiens_hsa052100.60561691
77Renin secretion_Homo sapiens_hsa049240.60091568
78GnRH signaling pathway_Homo sapiens_hsa049120.59945544
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59250660
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59168899
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58654255
82p53 signaling pathway_Homo sapiens_hsa041150.55646614
83mTOR signaling pathway_Homo sapiens_hsa041500.54571941
84ErbB signaling pathway_Homo sapiens_hsa040120.54441970
85Thyroid hormone synthesis_Homo sapiens_hsa049180.53765956
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53400405
87Fatty acid biosynthesis_Homo sapiens_hsa000610.53066852
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52913310
89Glucagon signaling pathway_Homo sapiens_hsa049220.52079747
90TNF signaling pathway_Homo sapiens_hsa046680.50365241
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49990336
92Salmonella infection_Homo sapiens_hsa051320.48476972
93Shigellosis_Homo sapiens_hsa051310.47946394
94Vibrio cholerae infection_Homo sapiens_hsa051100.46371980
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46112028
96Choline metabolism in cancer_Homo sapiens_hsa052310.45914871
97MAPK signaling pathway_Homo sapiens_hsa040100.44746582
98Prolactin signaling pathway_Homo sapiens_hsa049170.44102859
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.42866892
100FoxO signaling pathway_Homo sapiens_hsa040680.41625151
101Oxytocin signaling pathway_Homo sapiens_hsa049210.41418582
102Apoptosis_Homo sapiens_hsa042100.41086824
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.40886554
104Viral carcinogenesis_Homo sapiens_hsa052030.40132569
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40068531
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39716260
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39467727
108Renin-angiotensin system_Homo sapiens_hsa046140.39044402
109Complement and coagulation cascades_Homo sapiens_hsa046100.38558799
110Bile secretion_Homo sapiens_hsa049760.38437984
111cAMP signaling pathway_Homo sapiens_hsa040240.38166579
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37275805
113Long-term depression_Homo sapiens_hsa047300.36966159
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33572421
115Galactose metabolism_Homo sapiens_hsa000520.31671713
116Pertussis_Homo sapiens_hsa051330.31073350
117Inositol phosphate metabolism_Homo sapiens_hsa005620.31042812
118Cocaine addiction_Homo sapiens_hsa050300.30136294
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30077957
120N-Glycan biosynthesis_Homo sapiens_hsa005100.29734164

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