COL26A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing an emilin domain and two collagen stretches. This gene may be associated with aspirin-intolerant asthma. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)4.98735106
2regulation of gene silencing by miRNA (GO:0060964)4.98735106
3regulation of gene silencing by RNA (GO:0060966)4.98735106
4mesenchymal cell differentiation involved in kidney development (GO:0072161)4.75110769
5mesenchymal cell differentiation involved in renal system development (GO:2001012)4.75110769
6regulation of non-canonical Wnt signaling pathway (GO:2000050)4.73295454
7head development (GO:0060322)4.71617382
8mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.52960867
9regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.43245189
10planar cell polarity pathway involved in neural tube closure (GO:0090179)4.31098572
11metanephric mesenchyme development (GO:0072075)4.25974034
12outer ear morphogenesis (GO:0042473)4.24751548
13kidney mesenchyme development (GO:0072074)4.19957982
14proximal/distal pattern formation (GO:0009954)4.09077112
15embryonic forelimb morphogenesis (GO:0035115)4.08849809
16paraxial mesoderm development (GO:0048339)4.03176955
17bone trabecula formation (GO:0060346)4.02491591
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.01946979
19lung-associated mesenchyme development (GO:0060484)3.98905548
20heterochromatin organization (GO:0070828)3.95062892
21mesenchyme morphogenesis (GO:0072132)3.92909433
22regulation of cell fate specification (GO:0042659)3.90648025
23presynaptic membrane assembly (GO:0097105)3.90518684
24forelimb morphogenesis (GO:0035136)3.86431742
25lateral sprouting from an epithelium (GO:0060601)3.84676381
26cell proliferation involved in metanephros development (GO:0072203)3.84257196
27embryonic skeletal joint morphogenesis (GO:0060272)3.82344911
28L-serine metabolic process (GO:0006563)3.80867198
29G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.72736706
30middle ear morphogenesis (GO:0042474)3.70553772
31cochlea morphogenesis (GO:0090103)3.56262387
32postsynaptic membrane organization (GO:0001941)3.54210539
33embryonic cranial skeleton morphogenesis (GO:0048701)3.53628821
34pre-miRNA processing (GO:0031054)3.52652465
35face development (GO:0060324)3.51295055
36mesenchymal cell differentiation (GO:0048762)3.51250554
37endocardial cushion morphogenesis (GO:0003203)3.49575389
38embryonic appendage morphogenesis (GO:0035113)3.48762495
39embryonic limb morphogenesis (GO:0030326)3.48762495
40presynaptic membrane organization (GO:0097090)3.46224281
41mesenchymal to epithelial transition (GO:0060231)3.46159654
42mesonephros development (GO:0001823)3.42895518
43hindlimb morphogenesis (GO:0035137)3.41971729
44cell proliferation involved in kidney development (GO:0072111)3.38407769
45embryonic skeletal system morphogenesis (GO:0048704)3.31859056
46embryonic hindlimb morphogenesis (GO:0035116)3.31681286
47mesenchymal cell proliferation (GO:0010463)3.31276814
48negative regulation of axon extension involved in axon guidance (GO:0048843)3.30423170
49pyrimidine nucleobase catabolic process (GO:0006208)3.28521715
50cranial nerve morphogenesis (GO:0021602)3.26674820
51positive regulation of gastrulation (GO:2000543)3.23544077
52positive regulation of smoothened signaling pathway (GO:0045880)3.22865211
53vocalization behavior (GO:0071625)3.21448877
54appendage morphogenesis (GO:0035107)3.20403569
55limb morphogenesis (GO:0035108)3.20403569
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.19620426
57establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.18247446
58establishment of monopolar cell polarity (GO:0061162)3.13065127
59establishment or maintenance of monopolar cell polarity (GO:0061339)3.13065127
60ganglion development (GO:0061548)3.12487287
61eyelid development in camera-type eye (GO:0061029)3.12474664
62camera-type eye morphogenesis (GO:0048593)3.11010870
63establishment of planar polarity (GO:0001736)3.10990760
64establishment of tissue polarity (GO:0007164)3.10990760
65pattern specification involved in kidney development (GO:0061004)3.10283474
66embryonic digit morphogenesis (GO:0042733)3.09723476
67negative regulation of cell fate specification (GO:0009996)3.08879306
68sequestering of extracellular ligand from receptor (GO:0035581)3.08206022
69regulation of establishment of planar polarity (GO:0090175)3.06722854
70extracellular regulation of signal transduction (GO:1900115)3.06415616
71extracellular negative regulation of signal transduction (GO:1900116)3.06415616
72cell migration in hindbrain (GO:0021535)3.05559140
73regulation of stem cell maintenance (GO:2000036)3.05439620
74establishment of apical/basal cell polarity (GO:0035089)3.04793035
75neural crest cell development (GO:0014032)3.03986466
76convergent extension (GO:0060026)3.02554277
77branching involved in salivary gland morphogenesis (GO:0060445)3.01703977
78regulation of mesenchymal cell apoptotic process (GO:2001053)3.01686093
79cell differentiation involved in metanephros development (GO:0072202)3.01309504
80non-canonical Wnt signaling pathway (GO:0035567)3.01074617
81negative regulation of chondrocyte differentiation (GO:0032331)3.00914743
82regulation of heart morphogenesis (GO:2000826)2.99719080
83protein-DNA complex disassembly (GO:0032986)2.98531253
84nucleosome disassembly (GO:0006337)2.98531253
85positive regulation of catenin import into nucleus (GO:0035413)2.97414477
86DNA integration (GO:0015074)2.96990415
87regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.96894936
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.96765256
89axon extension involved in axon guidance (GO:0048846)2.96765256
90negative regulation of axon guidance (GO:1902668)2.96664895
91urogenital system development (GO:0001655)2.94698823
92facial nerve structural organization (GO:0021612)2.91766779
93positive regulation of SMAD protein import into nucleus (GO:0060391)2.89509652
94cornea development in camera-type eye (GO:0061303)2.89495192
95metanephros development (GO:0001656)2.89370427
96cell differentiation involved in kidney development (GO:0061005)2.88753310
97palate development (GO:0060021)2.87578062
98regulation of catenin import into nucleus (GO:0035412)2.87568116
99digestive tract morphogenesis (GO:0048546)2.86317162
100embryonic digestive tract development (GO:0048566)2.85483644
101epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.85101156
102neuron cell-cell adhesion (GO:0007158)2.84579874
103mesenchymal cell development (GO:0014031)2.83797785
104negative regulation of catenin import into nucleus (GO:0035414)2.82496795
105establishment of integrated proviral latency (GO:0075713)2.81391289
106negative regulation of cell fate commitment (GO:0010454)2.81088070
107regulation of cell fate commitment (GO:0010453)2.79928057
108negative regulation of stem cell proliferation (GO:2000647)2.79180310
109cell fate commitment involved in formation of primary germ layer (GO:0060795)2.79178865
110skeletal system morphogenesis (GO:0048705)2.77387922
111apical protein localization (GO:0045176)2.76488407
112regulation of organ formation (GO:0003156)2.76455647
113negative regulation of embryonic development (GO:0045992)2.76094693
114body morphogenesis (GO:0010171)2.75482933
115generation of neurons (GO:0048699)2.74798139
116inner ear receptor cell development (GO:0060119)2.73009898
117post-anal tail morphogenesis (GO:0036342)2.72470462
118cranial nerve structural organization (GO:0021604)2.72345380
119establishment or maintenance of apical/basal cell polarity (GO:0035088)2.70141231
120establishment or maintenance of bipolar cell polarity (GO:0061245)2.70141231
121regulation of short-term neuronal synaptic plasticity (GO:0048172)2.69373004
122chondrocyte differentiation (GO:0002062)2.69220343
123mesenchyme development (GO:0060485)2.68420703
124cell proliferation in forebrain (GO:0021846)2.68128875
125cell migration involved in heart development (GO:0060973)2.67790970
126negative chemotaxis (GO:0050919)2.67789380
127limb bud formation (GO:0060174)2.67477445
128notochord development (GO:0030903)2.66307789
129histone arginine methylation (GO:0034969)2.65603623
130protein heterotrimerization (GO:0070208)2.65242182
131regulation of gastrulation (GO:0010470)2.64753550
132embryonic organ morphogenesis (GO:0048562)2.63332228
133neuron recognition (GO:0008038)2.63028033
134hippo signaling (GO:0035329)2.61845151
135regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61582748
136positive regulation of embryonic development (GO:0040019)2.61427079
137regulation of somitogenesis (GO:0014807)2.60222150
138protein localization to synapse (GO:0035418)2.58801212
139negative regulation of keratinocyte proliferation (GO:0010839)2.58413090
140regulation of synaptic vesicle exocytosis (GO:2000300)2.57923786
141branching involved in ureteric bud morphogenesis (GO:0001658)2.57569916
142somatic stem cell division (GO:0048103)2.56849069
143anatomical structure regression (GO:0060033)2.56700042
144regulation of mesenchymal cell proliferation (GO:0010464)2.56431988
145axonal fasciculation (GO:0007413)2.56008957
146regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55938763
147regulation of cardioblast proliferation (GO:0003264)2.55938763
148nephron epithelium morphogenesis (GO:0072088)2.55569074
149nephron tubule morphogenesis (GO:0072078)2.55569074
150dorsal/ventral axis specification (GO:0009950)2.55123276
151layer formation in cerebral cortex (GO:0021819)2.54707350
152short-term memory (GO:0007614)2.53911856
153ephrin receptor signaling pathway (GO:0048013)2.53096348
154synaptic vesicle docking involved in exocytosis (GO:0016081)2.52874734
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52637614
156positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.52346348
157cell communication by electrical coupling (GO:0010644)2.52052334
158locomotory exploration behavior (GO:0035641)2.46649714
159positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46088958
160DNA unwinding involved in DNA replication (GO:0006268)2.46077507
161axon extension (GO:0048675)2.45321412
162lens fiber cell development (GO:0070307)2.44493420
163embryonic body morphogenesis (GO:0010172)2.43197478
164nucleobase catabolic process (GO:0046113)2.42796819
165regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41681156
166neural tube development (GO:0021915)2.39126705
167innervation (GO:0060384)2.38107673
168ribosomal small subunit assembly (GO:0000028)2.38091058
169cranial nerve development (GO:0021545)2.36411180
170neural tube closure (GO:0001843)2.35931114
171tube closure (GO:0060606)2.34295526
172peptidyl-arginine omega-N-methylation (GO:0035247)2.34127275
173exploration behavior (GO:0035640)2.33054024
174regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.32857672
175dendritic spine morphogenesis (GO:0060997)2.32727870
176regulation of mesoderm development (GO:2000380)2.31038353
177negative regulation of gene silencing (GO:0060969)2.28799433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.73681205
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.72745159
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38018802
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.35209430
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22896272
6CBX2_27304074_Chip-Seq_ESCs_Mouse3.16623201
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12544296
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.08578101
9BMI1_23680149_ChIP-Seq_NPCS_Mouse3.07219081
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.99875159
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.98054644
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.97510289
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.86134101
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80635851
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80635851
16RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.77255340
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66183791
18GBX2_23144817_ChIP-Seq_PC3_Human2.65560464
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.59177118
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.58348034
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.54921531
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.54601836
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51979725
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50900444
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42710462
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.42621238
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.22186248
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.07558906
29POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07292115
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06982431
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.05672690
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.05672690
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.05672690
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03041112
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01391094
36RNF2_27304074_Chip-Seq_NSC_Mouse1.99572557
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.96456846
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96336847
39E2F7_22180533_ChIP-Seq_HELA_Human1.88106033
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.87493886
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.84149887
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83318428
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80960456
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73341090
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72223575
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.69803439
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.66752807
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.65978243
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64741409
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63138021
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.59091044
52FUS_26573619_Chip-Seq_HEK293_Human1.58842909
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.58743653
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57482088
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54119038
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51707909
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51547424
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.49836662
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48768608
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48745430
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.48460205
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48197845
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47194961
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47194961
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46588170
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45901519
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45320060
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44042645
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43887289
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.43810129
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42964467
72AR_21572438_ChIP-Seq_LNCaP_Human1.42714747
73P300_19829295_ChIP-Seq_ESCs_Human1.41588804
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39536257
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.39245895
76EWS_26573619_Chip-Seq_HEK293_Human1.37653441
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36793116
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34965883
79TP53_18474530_ChIP-ChIP_U2OS_Human1.33232641
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33121319
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29184244
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.28004005
83REST_21632747_ChIP-Seq_MESCs_Mouse1.27098996
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25323218
85CTCF_27219007_Chip-Seq_Bcells_Human1.24888564
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24446535
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24284880
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23108218
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22087982
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21918024
91TAF15_26573619_Chip-Seq_HEK293_Human1.21805006
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.21626321
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.21562291
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20845252
95KDM2B_26808549_Chip-Seq_K562_Human1.20820105
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20171595
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.19985129
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19621998
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19473857
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19410256
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19378949
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19188728
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.18872742
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.17139359
105DROSHA_22980978_ChIP-Seq_HELA_Human1.16856540
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16587823
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13412984
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11853403
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11301530
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09829593
111THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08687055
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.08443460
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08346343
114SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08226486
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07628618
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07515854
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06816809
118XRN2_22483619_ChIP-Seq_HELA_Human1.06677261
119TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05744184
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05217117
121OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04908112
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.04670288
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04507884
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03950369
125SMAD4_21799915_ChIP-Seq_A2780_Human1.03186589
126IGF1R_20145208_ChIP-Seq_DFB_Human1.02718793
127VDR_22108803_ChIP-Seq_LS180_Human1.01999351
128MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01956830
129SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01873467
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01807600
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01350801
132RARB_27405468_Chip-Seq_BRAIN_Mouse1.01121597
133PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99919496
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.98960473
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.98723834
136AHR_22903824_ChIP-Seq_MCF-7_Human0.98391246
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.97229443
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96809130
139RUNX2_22187159_ChIP-Seq_PCA_Human0.96784055
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.95065234
141STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94695932
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94040508
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92976151
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92667927
145P53_22387025_ChIP-Seq_ESCs_Mouse0.92576991
146EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92147795
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.91539050
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.90879859
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89933235
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87918778
151EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87145886
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86089479
153SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85842310
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85726567
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85630093
156SOX9_26525672_Chip-Seq_HEART_Mouse0.85136792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.43857207
2MP0010030_abnormal_orbit_morphology3.27456729
3MP0003385_abnormal_body_wall3.23694539
4MP0005503_abnormal_tendon_morphology3.22440917
5MP0002249_abnormal_larynx_morphology2.97495711
6MP0000049_abnormal_middle_ear2.91418468
7MP0000566_synostosis2.85207152
8MP0009250_abnormal_appendicular_skeleto2.82133415
9MP0004859_abnormal_synaptic_plasticity2.76491346
10MP0002938_white_spotting2.62566159
11MP0003942_abnormal_urinary_system2.52696903
12MP0003123_paternal_imprinting2.43330207
13MP0003121_genomic_imprinting2.19615284
14MP0003941_abnormal_skin_development2.12636084
15MP0009053_abnormal_anal_canal2.10526897
16MP0003937_abnormal_limbs/digits/tail_de2.07248995
17MP0003787_abnormal_imprinting2.03393407
18MP0001188_hyperpigmentation2.03185596
19MP0003938_abnormal_ear_development2.02800897
20MP0002233_abnormal_nose_morphology1.96820749
21MP0000534_abnormal_ureter_morphology1.93516787
22MP0003755_abnormal_palate_morphology1.87533648
23MP0000762_abnormal_tongue_morphology1.86966079
24MP0002254_reproductive_system_inflammat1.85092771
25MP0002102_abnormal_ear_morphology1.84585422
26MP0003136_yellow_coat_color1.81913331
27MP0002932_abnormal_joint_morphology1.81104993
28MP0009379_abnormal_foot_pigmentation1.78866893
29MP0005248_abnormal_Harderian_gland1.77644448
30MP0000537_abnormal_urethra_morphology1.77280547
31MP0002116_abnormal_craniofacial_bone1.75527269
32MP0008438_abnormal_cutaneous_collagen1.75305886
33MP0009672_abnormal_birth_weight1.71496768
34MP0003935_abnormal_craniofacial_develop1.62443968
35MP0003890_abnormal_embryonic-extraembry1.61601342
36MP0002282_abnormal_trachea_morphology1.61453539
37MP0002109_abnormal_limb_morphology1.60793439
38MP0000678_abnormal_parathyroid_gland1.59788424
39MP0005623_abnormal_meninges_morphology1.59265866
40MP0003315_abnormal_perineum_morphology1.58683811
41MP0006292_abnormal_olfactory_placode1.57956320
42MP0005171_absent_coat_pigmentation1.54344194
43MP0005508_abnormal_skeleton_morphology1.53584365
44MP0008789_abnormal_olfactory_epithelium1.52482789
45MP0003635_abnormal_synaptic_transmissio1.41285251
46MP0001270_distended_abdomen1.39786146
47MP0000569_abnormal_digit_pigmentation1.38549073
48MP0004272_abnormal_basement_membrane1.36344978
49MP0005367_renal/urinary_system_phenotyp1.36037764
50MP0000516_abnormal_urinary_system1.36037764
51MP0000432_abnormal_head_morphology1.35411036
52MP0000026_abnormal_inner_ear1.33634184
53MP0000428_abnormal_craniofacial_morphol1.32842122
54MP0000778_abnormal_nervous_system1.31873575
55MP0000955_abnormal_spinal_cord1.30309191
56MP0004270_analgesia1.29140875
57MP0001984_abnormal_olfaction1.28639644
58MP0000163_abnormal_cartilage_morphology1.28050862
59MP0001286_abnormal_eye_development1.27349926
60MP0002085_abnormal_embryonic_tissue1.22631885
61MP0002114_abnormal_axial_skeleton1.22239976
62MP0002084_abnormal_developmental_patter1.21043486
63MP0001346_abnormal_lacrimal_gland1.20800616
64MP0008932_abnormal_embryonic_tissue1.20590467
65MP0000631_abnormal_neuroendocrine_gland1.19452595
66MP0003693_abnormal_embryo_hatching1.19401122
67MP0001177_atelectasis1.19007411
68MP0002177_abnormal_outer_ear1.18939110
69MP0002115_abnormal_skeleton_extremities1.18833001
70MP0002063_abnormal_learning/memory/cond1.18085184
71MP0002163_abnormal_gland_morphology1.18053561
72MP0001293_anophthalmia1.17695145
73MP0001849_ear_inflammation1.16893204
74MP0002152_abnormal_brain_morphology1.16485267
75MP0003119_abnormal_digestive_system1.15699606
76MP0004858_abnormal_nervous_system1.15522384
77MP0003115_abnormal_respiratory_system1.14105061
78MP0002736_abnormal_nociception_after1.13717480
79MP0002089_abnormal_postnatal_growth/wei1.13061002
80MP0002734_abnormal_mechanical_nocicepti1.11229928
81MP0004957_abnormal_blastocyst_morpholog1.11098995
82MP0000462_abnormal_digestive_system1.10178791
83MP0000613_abnormal_salivary_gland1.09703988
84MP0002111_abnormal_tail_morphology1.06665117
85MP0004134_abnormal_chest_morphology1.03375462
86MP0002751_abnormal_autonomic_nervous1.02966717
87MP0001529_abnormal_vocalization1.02667307
88MP0002113_abnormal_skeleton_development1.02462131
89MP0001968_abnormal_touch/_nociception1.02443336
90MP0005423_abnormal_somatic_nervous1.01860667
91MP0008877_abnormal_DNA_methylation1.01353694
92MP0005197_abnormal_uvea_morphology1.00676584
93MP0005409_darkened_coat_color0.99989249
94MP0005394_taste/olfaction_phenotype0.98309858
95MP0005499_abnormal_olfactory_system0.98309858
96MP0004381_abnormal_hair_follicle0.97688201
97MP0005275_abnormal_skin_tensile0.96240020
98MP0005257_abnormal_intraocular_pressure0.96053845
99MP0002108_abnormal_muscle_morphology0.95883403
100MP0002572_abnormal_emotion/affect_behav0.94432142
101MP0002735_abnormal_chemical_nociception0.93645337
102MP0001340_abnormal_eyelid_morphology0.93389189
103MP0005377_hearing/vestibular/ear_phenot0.92995614
104MP0003878_abnormal_ear_physiology0.92995614
105MP0002184_abnormal_innervation0.92919353
106MP0003861_abnormal_nervous_system0.92744713
107MP0003567_abnormal_fetal_cardiomyocyte0.91886237
108MP0002557_abnormal_social/conspecific_i0.90005291
109MP0000579_abnormal_nail_morphology0.88661699
110MP0002882_abnormal_neuron_morphology0.88386081
111MP0002081_perinatal_lethality0.87203825
112MP0000383_abnormal_hair_follicle0.86895440
113MP0006276_abnormal_autonomic_nervous0.86777457
114MP0002277_abnormal_respiratory_mucosa0.85795979
115MP0003111_abnormal_nucleus_morphology0.85716725
116MP0002272_abnormal_nervous_system0.85231935
117MP0004811_abnormal_neuron_physiology0.85167470
118MP0001486_abnormal_startle_reflex0.84593184
119MP0009745_abnormal_behavioral_response0.84540254
120MP0002697_abnormal_eye_size0.83047111
121MP0000733_abnormal_muscle_development0.82329621
122MP0003880_abnormal_central_pattern0.80993788
123MP0004197_abnormal_fetal_growth/weight/0.78832972
124MP0000767_abnormal_smooth_muscle0.74281162
125MP0001963_abnormal_hearing_physiology0.74115714
126MP0003283_abnormal_digestive_organ0.73604295
127MP0008058_abnormal_DNA_repair0.71441830
128MP0009703_decreased_birth_body0.70239382
129MP0002752_abnormal_somatic_nervous0.70035035
130MP0002092_abnormal_eye_morphology0.69246962
131MP0004742_abnormal_vestibular_system0.67644912
132MP0002653_abnormal_ependyma_morphology0.67339715
133MP0001299_abnormal_eye_distance/0.66411080
134MP0002234_abnormal_pharynx_morphology0.65489520
135MP0004133_heterotaxia0.64599224
136MP0005391_vision/eye_phenotype0.63254716
137MP0005379_endocrine/exocrine_gland_phen0.62388346

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.10368556
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.10368556
3Renal duplication (HP:0000075)4.06387080
4Turricephaly (HP:0000262)3.98767476
5Abnormality of the parietal bone (HP:0002696)3.72199371
6Midline defect of the nose (HP:0004122)3.36835993
7Abnormality of the 4th metacarpal (HP:0010012)3.16595948
8Bronchomalacia (HP:0002780)3.08236167
9High anterior hairline (HP:0009890)2.95861659
10Partial duplication of thumb phalanx (HP:0009944)2.95233244
11Choanal stenosis (HP:0000452)2.93655186
12Mesomelia (HP:0003027)2.89133941
13Nephroblastoma (Wilms tumor) (HP:0002667)2.87723432
14Short middle phalanx of the 5th finger (HP:0004220)2.86997557
15Broad thumb (HP:0011304)2.83286888
16Rib fusion (HP:0000902)2.80119181
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78553446
18Embryonal renal neoplasm (HP:0011794)2.77378552
19Morphological abnormality of the middle ear (HP:0008609)2.76123169
20Supernumerary ribs (HP:0005815)2.71039279
21Cutaneous finger syndactyly (HP:0010554)2.69689744
22Abnormality of the labia minora (HP:0012880)2.65702470
23Myokymia (HP:0002411)2.65040568
24Flat cornea (HP:0007720)2.64263552
25Shallow orbits (HP:0000586)2.61479345
26Renovascular hypertension (HP:0100817)2.58432331
27Supernumerary bones of the axial skeleton (HP:0009144)2.57137829
28Asymmetry of the thorax (HP:0001555)2.53922903
29Abnormality of abdominal situs (HP:0011620)2.45994301
30Abdominal situs inversus (HP:0003363)2.45994301
31Hepatoblastoma (HP:0002884)2.44005891
32Broad phalanges of the hand (HP:0009768)2.42672034
33Cutaneous syndactyly (HP:0012725)2.40771820
34Broad long bones (HP:0005622)2.39557303
35Abnormality of dentin (HP:0010299)2.37957897
36Abnormality of the phalanges of the hallux (HP:0010057)2.37304432
37Broad finger (HP:0001500)2.37160249
38Colon cancer (HP:0003003)2.34734610
39Broad phalanx (HP:0006009)2.27875670
40Abnormality of the nasolacrimal system (HP:0000614)2.27853294
41Vitreoretinal degeneration (HP:0000655)2.27332705
42Chromsome breakage (HP:0040012)2.26567354
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.25601667
44Bladder diverticulum (HP:0000015)2.25024429
45Cortical dysplasia (HP:0002539)2.24899483
46Broad toe (HP:0001837)2.24508768
47Tracheomalacia (HP:0002779)2.24028037
48Bilateral microphthalmos (HP:0007633)2.23792516
49Abnormal ciliary motility (HP:0012262)2.20336467
50Reticulocytopenia (HP:0001896)2.20146165
51Coronal craniosynostosis (HP:0004440)2.19604083
52Thin ribs (HP:0000883)2.18270538
53Irregular epiphyses (HP:0010582)2.15505455
54Abnormality of the calcaneus (HP:0008364)2.14492998
55Renal dysplasia (HP:0000110)2.09683908
56Synostosis involving the elbow (HP:0003938)2.09597568
57Humeroradial synostosis (HP:0003041)2.09597568
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.08940736
59Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.08689495
60Arnold-Chiari malformation (HP:0002308)2.08239548
61Chin dimple (HP:0010751)2.08228161
62Aplasia involving bones of the upper limbs (HP:0009823)2.06364909
63Aplasia of the phalanges of the hand (HP:0009802)2.06364909
64Aplasia involving bones of the extremities (HP:0009825)2.06364909
65Maternal diabetes (HP:0009800)2.06255473
66Narrow nasal bridge (HP:0000446)2.04535610
67Absent septum pellucidum (HP:0001331)2.04417322
68Overriding aorta (HP:0002623)2.03965824
69Genu recurvatum (HP:0002816)2.02450761
70Abnormality of the phalanges of the 5th finger (HP:0004213)2.01790997
71Patellar dislocation (HP:0002999)2.01697267
72Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.00369069
73Elfin facies (HP:0004428)1.98954423
74Septo-optic dysplasia (HP:0100842)1.98182486
75Hyperacusis (HP:0010780)1.96726366
76Hypoplastic pelvis (HP:0008839)1.96381877
77Aqueductal stenosis (HP:0002410)1.95489770
78Follicular hyperkeratosis (HP:0007502)1.94581843
79Partial duplication of the phalanx of hand (HP:0009999)1.94163996
80Microglossia (HP:0000171)1.93982255
81Abnormality of the aortic arch (HP:0012303)1.93682415
82Premature rupture of membranes (HP:0001788)1.93643955
83White forelock (HP:0002211)1.93313467
84Neonatal short-limb short stature (HP:0008921)1.92868168
85Metaphyseal cupping (HP:0003021)1.92608752
86Abnormality of the renal collecting system (HP:0004742)1.92208986
87Abnormal number of incisors (HP:0011064)1.91666847
88Bifid tongue (HP:0010297)1.91406654
89Increased number of teeth (HP:0011069)1.91252267
90Abnormal lung lobation (HP:0002101)1.90767880
91Skull defect (HP:0001362)1.90617175
92Duplication of thumb phalanx (HP:0009942)1.90246808
93Meckel diverticulum (HP:0002245)1.89509284
94Bell-shaped thorax (HP:0001591)1.89320617
95Spinal cord lesions (HP:0100561)1.89127312
96Syringomyelia (HP:0003396)1.89127312
97Hyperglycinemia (HP:0002154)1.88862103
98Hemivertebrae (HP:0002937)1.88816139
99Anophthalmia (HP:0000528)1.87828751
100Sleep apnea (HP:0010535)1.87820580
101Occipital encephalocele (HP:0002085)1.86701084
102Broad metatarsal (HP:0001783)1.86573619
103Generalized hypotonia (HP:0001290)1.86472685
104Trigonocephaly (HP:0000243)1.86007567
105Concave nail (HP:0001598)1.85864291
106Abnormal sex determination (HP:0012244)1.85485932
107Sex reversal (HP:0012245)1.85485932
108True hermaphroditism (HP:0010459)1.85037077
109Diastasis recti (HP:0001540)1.84684367
110Absent eyebrow (HP:0002223)1.84053750
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83984974
112Absent epiphyses (HP:0010577)1.83984974
113Broad palm (HP:0001169)1.83352751
114Deviation of the hallux (HP:0010051)1.82822179
115Stenosis of the external auditory canal (HP:0000402)1.82562352
116Upper limb muscle weakness (HP:0003484)1.82343759
117Bowel diverticulosis (HP:0005222)1.82029338
118Calcaneovalgus deformity (HP:0001848)1.81728124
119Down-sloping shoulders (HP:0200021)1.81013889
120Aplasia cutis congenita (HP:0001057)1.80907970
121Abnormality of the ileum (HP:0001549)1.80489289
122Abnormality of the 2nd finger (HP:0004100)1.79733863
123Abnormality of the lacrimal duct (HP:0011481)1.79394430
124Broad hallux (HP:0010055)1.79000130
125Soft skin (HP:0000977)1.78532731
126Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75884219
127Embryonal neoplasm (HP:0002898)1.75751839
128Myelomeningocele (HP:0002475)1.75530440
129Aplasia/Hypoplasia of the breasts (HP:0010311)1.74770840
130Abnormality of the incisor (HP:0000676)1.74516193
131Sprengel anomaly (HP:0000912)1.73752174
132Duplicated collecting system (HP:0000081)1.73142848
133Abnormality of the septum pellucidum (HP:0007375)1.72481868
134Long palpebral fissure (HP:0000637)1.72287354
135Abnormality of cochlea (HP:0000375)1.71840040
136Ectopic kidney (HP:0000086)1.71641999
137Abnormality of the diencephalon (HP:0010662)1.71378050
138Ectopic anus (HP:0004397)1.71303248
139Split foot (HP:0001839)1.71067092
140Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69854803
141Protrusio acetabuli (HP:0003179)1.69263437
142Preaxial foot polydactyly (HP:0001841)1.68610599
143Hypoplastic ischia (HP:0003175)1.67733850
144Atrophic scars (HP:0001075)1.67483943
145Breast aplasia (HP:0100783)1.67338041
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.67228853
147Pulmonary artery stenosis (HP:0004415)1.66983300
148Short 5th finger (HP:0009237)1.66871814
149Omphalocele (HP:0001539)1.66822705
150Pointed chin (HP:0000307)1.65941572
151Hallux valgus (HP:0001822)1.64555503
152Wide anterior fontanel (HP:0000260)1.64511454
153Atresia of the external auditory canal (HP:0000413)1.64120363
154Increased nuchal translucency (HP:0010880)1.63141435
155Nasolacrimal duct obstruction (HP:0000579)1.63134445
156Mixed hearing impairment (HP:0000410)1.62653120
157Congenital sensorineural hearing impairment (HP:0008527)1.62320785
158Mild short stature (HP:0003502)1.61600736
159Fragile skin (HP:0001030)1.61510387
160Abnormality of incisor morphology (HP:0011063)1.61237161
161Synostosis of carpal bones (HP:0005048)1.61229796
162Renal hypoplasia (HP:0000089)1.60967896
163Ulnar bowing (HP:0003031)1.60779205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.55625464
2TLK13.95003799
3MKNK23.11374966
4DDR23.03384039
5EPHB22.98151737
6EPHA32.88449895
7CDK192.82528722
8MKNK12.62214838
9TYRO32.58779920
10NTRK12.51644296
11SRPK12.44614091
12STK38L2.37764891
13CDC72.23980338
14STK162.20769454
15ZAK2.20302160
16MAP3K92.07448283
17LATS11.94161053
18EIF2AK21.88908351
19IRAK21.80692301
20SMG11.79253897
21MAP3K101.66077758
22SIK31.62694127
23VRK21.57235728
24ERBB31.55484777
25CAMK1D1.53232782
26EEF2K1.49995152
27MAPK131.49035573
28NUAK11.48154407
29IRAK11.45844769
30CLK11.45505605
31GRK11.45382100
32TAF11.40408216
33YES11.38148173
34SIK21.36591584
35MINK11.36066645
36BRD41.33355487
37LATS21.30665942
38FGFR41.22753125
39TNIK1.22248566
40IRAK31.21689032
41RIPK11.19460390
42AKT31.18934803
43PLK21.16373516
44CAMK1G1.09198557
45BMX1.09148223
46PRPF4B1.09002376
47TTK1.03853086
48MAP2K71.01413413
49PNCK1.01172381
50NTRK31.00757273
51MAP3K41.00307149
52MARK10.97081784
53NTRK20.96970746
54CSNK1G20.96826470
55NEK60.96443595
56PDGFRA0.94443379
57ALK0.94222866
58IRAK40.93376760
59CDK11A0.93165911
60CDK150.92111771
61CDK30.91341303
62BUB10.90773713
63CDK80.90537274
64ERBB20.90206270
65CDK180.89178243
66DYRK20.86314551
67TSSK60.86239334
68STK30.86142832
69ADRBK20.85436355
70PKN10.85097440
71CSNK1A1L0.84812723
72DMPK0.81018633
73PRKD30.80438553
74UHMK10.80036366
75CDK70.79282229
76AURKA0.79217510
77WNK30.78913668
78CDK140.78810683
79NEK20.76729037
80BRSK10.75693709
81CDK50.74916064
82EPHA40.73126207
83PLK40.72057617
84BCR0.71403852
85TXK0.70528765
86PLK30.69794998
87PRKCE0.69759111
88TAOK20.69303389
89PRKD20.69190913
90STK110.68789653
91PAK60.68656888
92CSNK1E0.68528441
93WNK10.66625361
94BMPR1B0.66108539
95DYRK30.65375892
96SIK10.65323351
97ICK0.64424629
98CAMK10.63956413
99SGK4940.63334144
100SGK2230.63334144
101BRAF0.61773209
102MARK20.59080935
103ATR0.58109515
104CHEK20.56059342
105LIMK10.55099713
106CDK20.53622998
107CHEK10.53084131
108DYRK1A0.52998691
109FGR0.52218709
110NME10.51987097
111MAP3K110.51628255
112MTOR0.51359219
113ADRBK10.51322053
114BLK0.50501964
115VRK10.49933592
116FGFR10.49466171
117PRKCZ0.47174726
118CHUK0.46212667
119PRKCI0.46126682
120AKT10.44714511
121MAPK70.43241493
122ATM0.42424313
123CDK120.42409850
124CSNK1G10.42367390
125PLK10.42154425
126NEK10.41717771
127ROCK20.41492562
128AURKB0.41137258
129PASK0.41088635
130MAP3K140.40807871
131CDC42BPA0.39857155
132DAPK20.39111495
133AKT20.38516297
134PIK3CA0.38390695
135CSNK1D0.38293211
136SGK20.38102117
137TRIM280.38057355
138PTK20.37461173
139ROCK10.37174439
140PRKCG0.37105456
141CDK10.36383497
142MAPK140.35870738
143PTK60.34884259
144CAMK40.33737744
145CSNK1G30.33552618
146PAK20.33530586
147FGFR20.31778838
148PRKG10.30836954
149RPS6KA20.28645182
150PRKDC0.28445497
151GSK3B0.28273385
152CDK90.27760894
153PDGFRB0.26847844

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.72860309
2Hedgehog signaling pathway_Homo sapiens_hsa043403.17743801
3Axon guidance_Homo sapiens_hsa043602.11184982
4Wnt signaling pathway_Homo sapiens_hsa043102.04706555
5Vitamin B6 metabolism_Homo sapiens_hsa007502.00869761
6Hippo signaling pathway_Homo sapiens_hsa043902.00719146
7Nicotine addiction_Homo sapiens_hsa050331.92850265
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92623957
9Fanconi anemia pathway_Homo sapiens_hsa034601.88794217
10Protein digestion and absorption_Homo sapiens_hsa049741.75822773
11ECM-receptor interaction_Homo sapiens_hsa045121.72473982
12Biosynthesis of amino acids_Homo sapiens_hsa012301.65231620
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.62302625
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53158461
15Notch signaling pathway_Homo sapiens_hsa043301.52274817
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.49336716
17Melanogenesis_Homo sapiens_hsa049161.47836423
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46782744
19Homologous recombination_Homo sapiens_hsa034401.46356895
20Phototransduction_Homo sapiens_hsa047441.45998132
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43119533
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42444809
23Steroid biosynthesis_Homo sapiens_hsa001001.34708127
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26424775
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.25943444
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20224603
27mRNA surveillance pathway_Homo sapiens_hsa030151.17201497
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15952101
29Spliceosome_Homo sapiens_hsa030401.15891270
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15266715
31Cell cycle_Homo sapiens_hsa041101.13955977
32Cardiac muscle contraction_Homo sapiens_hsa042601.12975228
33Pathways in cancer_Homo sapiens_hsa052001.12844292
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12338493
35Taste transduction_Homo sapiens_hsa047421.11643210
36TGF-beta signaling pathway_Homo sapiens_hsa043501.11548427
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08038713
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07890513
39Morphine addiction_Homo sapiens_hsa050321.06757628
40MicroRNAs in cancer_Homo sapiens_hsa052061.06474649
41Thyroid cancer_Homo sapiens_hsa052161.06085170
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05551875
43RNA transport_Homo sapiens_hsa030131.05454731
44HTLV-I infection_Homo sapiens_hsa051661.04458469
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03430163
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01162529
47Proteoglycans in cancer_Homo sapiens_hsa052050.98055291
48Synaptic vesicle cycle_Homo sapiens_hsa047210.96217978
49Adherens junction_Homo sapiens_hsa045200.93227668
50Melanoma_Homo sapiens_hsa052180.90142818
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89743915
52Gap junction_Homo sapiens_hsa045400.88859865
53Cocaine addiction_Homo sapiens_hsa050300.88171261
54Viral myocarditis_Homo sapiens_hsa054160.87257913
55Colorectal cancer_Homo sapiens_hsa052100.86948659
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86815404
57Base excision repair_Homo sapiens_hsa034100.86281747
58Prostate cancer_Homo sapiens_hsa052150.84710069
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83608674
60Focal adhesion_Homo sapiens_hsa045100.83459032
61Alcoholism_Homo sapiens_hsa050340.82735369
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82176903
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.81954167
64Autoimmune thyroid disease_Homo sapiens_hsa053200.80193056
65Long-term potentiation_Homo sapiens_hsa047200.79839065
66Small cell lung cancer_Homo sapiens_hsa052220.79644592
67Serotonergic synapse_Homo sapiens_hsa047260.79529931
68Ribosome_Homo sapiens_hsa030100.79017562
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79003011
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78137863
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.77349600
72Basal transcription factors_Homo sapiens_hsa030220.75886528
73Carbon metabolism_Homo sapiens_hsa012000.75634751
74Arginine and proline metabolism_Homo sapiens_hsa003300.75513360
75Glutamatergic synapse_Homo sapiens_hsa047240.74482520
76Dilated cardiomyopathy_Homo sapiens_hsa054140.74260415
77Sulfur relay system_Homo sapiens_hsa041220.73530447
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72640343
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70919059
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.70515497
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69910477
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68979216
83Oocyte meiosis_Homo sapiens_hsa041140.68832785
84Circadian entrainment_Homo sapiens_hsa047130.68711537
85Selenocompound metabolism_Homo sapiens_hsa004500.68222573
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67702695
87Chronic myeloid leukemia_Homo sapiens_hsa052200.67599186
88Endometrial cancer_Homo sapiens_hsa052130.67520036
89Pyruvate metabolism_Homo sapiens_hsa006200.65328699
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64893474
91Mismatch repair_Homo sapiens_hsa034300.64189912
92Rap1 signaling pathway_Homo sapiens_hsa040150.63987167
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63531885
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63470603
95ErbB signaling pathway_Homo sapiens_hsa040120.63444239
96Graft-versus-host disease_Homo sapiens_hsa053320.63278370
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63083088
98Ras signaling pathway_Homo sapiens_hsa040140.62035244
99Parkinsons disease_Homo sapiens_hsa050120.62002622
100Folate biosynthesis_Homo sapiens_hsa007900.61964004
101Arginine biosynthesis_Homo sapiens_hsa002200.61925585
102cAMP signaling pathway_Homo sapiens_hsa040240.61315375
103Ovarian steroidogenesis_Homo sapiens_hsa049130.60928874
104Insulin secretion_Homo sapiens_hsa049110.60797885
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60257085
106Cholinergic synapse_Homo sapiens_hsa047250.60161436
107Calcium signaling pathway_Homo sapiens_hsa040200.60116265
108Herpes simplex infection_Homo sapiens_hsa051680.59387129
109MAPK signaling pathway_Homo sapiens_hsa040100.59213277
110Systemic lupus erythematosus_Homo sapiens_hsa053220.59196938
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59173085
112Lysine degradation_Homo sapiens_hsa003100.59080089
113Thyroid hormone synthesis_Homo sapiens_hsa049180.57510880
114Allograft rejection_Homo sapiens_hsa053300.57343365
115Non-homologous end-joining_Homo sapiens_hsa034500.57227509
116Olfactory transduction_Homo sapiens_hsa047400.57070403
117Huntingtons disease_Homo sapiens_hsa050160.56878871
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56713618
119Amphetamine addiction_Homo sapiens_hsa050310.54532836
120Nucleotide excision repair_Homo sapiens_hsa034200.54471990
121Long-term depression_Homo sapiens_hsa047300.52982481
122Arachidonic acid metabolism_Homo sapiens_hsa005900.52887205
123p53 signaling pathway_Homo sapiens_hsa041150.51974764
124Malaria_Homo sapiens_hsa051440.51935864
125GABAergic synapse_Homo sapiens_hsa047270.50780034
126TNF signaling pathway_Homo sapiens_hsa046680.50021256
127One carbon pool by folate_Homo sapiens_hsa006700.49979162
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48698724
129Dopaminergic synapse_Homo sapiens_hsa047280.46403188
130Tight junction_Homo sapiens_hsa045300.46057594
131RNA polymerase_Homo sapiens_hsa030200.45024893
132N-Glycan biosynthesis_Homo sapiens_hsa005100.44817098
133Chemokine signaling pathway_Homo sapiens_hsa040620.44783802
134DNA replication_Homo sapiens_hsa030300.44660348
135Ether lipid metabolism_Homo sapiens_hsa005650.44134048
136Estrogen signaling pathway_Homo sapiens_hsa049150.43245909
137Measles_Homo sapiens_hsa051620.43096098
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42901818
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42588648
140RNA degradation_Homo sapiens_hsa030180.42288814
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41688091
142Asthma_Homo sapiens_hsa053100.41556696
143Fatty acid elongation_Homo sapiens_hsa000620.40616417
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40576974
145Alzheimers disease_Homo sapiens_hsa050100.35918053

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