COL19A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)7.42049373
2synaptic vesicle exocytosis (GO:0016079)6.54425260
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.53016474
4protein localization to synapse (GO:0035418)6.39389214
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58256622
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.54381333
7neuron cell-cell adhesion (GO:0007158)5.51457908
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.47630079
9regulation of glutamate receptor signaling pathway (GO:1900449)5.38780462
10neuronal action potential propagation (GO:0019227)5.24587647
11synaptic vesicle maturation (GO:0016188)5.10033223
12glutamate secretion (GO:0014047)5.02080002
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.92993866
14neurotransmitter secretion (GO:0007269)4.87493940
15negative regulation of synaptic transmission, GABAergic (GO:0032229)4.86109415
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.79069959
17locomotory exploration behavior (GO:0035641)4.69186823
18gamma-aminobutyric acid transport (GO:0015812)4.60268632
19regulation of synaptic vesicle exocytosis (GO:2000300)4.60134024
20indolalkylamine metabolic process (GO:0006586)4.52359700
21positive regulation of membrane potential (GO:0045838)4.51434738
22synaptic transmission, glutamatergic (GO:0035249)4.44844655
23indole-containing compound catabolic process (GO:0042436)4.43022220
24indolalkylamine catabolic process (GO:0046218)4.43022220
25tryptophan catabolic process (GO:0006569)4.43022220
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.42840744
27positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.32958977
28cilium or flagellum-dependent cell motility (GO:0001539)4.26851469
29neuron-neuron synaptic transmission (GO:0007270)4.25169827
30glutamate receptor signaling pathway (GO:0007215)4.24682393
31striated muscle atrophy (GO:0014891)4.18175795
32negative regulation of mast cell activation (GO:0033004)4.16603070
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.15934605
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.10892059
35neurotransmitter-gated ion channel clustering (GO:0072578)4.09832951
36positive regulation of synapse maturation (GO:0090129)4.09632010
37regulation of synaptic vesicle transport (GO:1902803)4.08567504
38interkinetic nuclear migration (GO:0022027)4.03995148
39regulation of B cell receptor signaling pathway (GO:0050855)4.03273670
40regulation of neuronal synaptic plasticity (GO:0048168)4.01991616
41proline transport (GO:0015824)4.01564191
42kynurenine metabolic process (GO:0070189)4.01045240
43tryptophan metabolic process (GO:0006568)3.98203493
44startle response (GO:0001964)3.98139795
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.96757077
46postsynaptic membrane organization (GO:0001941)3.95878968
47regulation of postsynaptic membrane potential (GO:0060078)3.88947243
48neurotransmitter transport (GO:0006836)3.84025988
49behavioral response to nicotine (GO:0035095)3.84023685
50presynaptic membrane assembly (GO:0097105)3.81947258
51exploration behavior (GO:0035640)3.80234703
52muscle atrophy (GO:0014889)3.78694334
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78260875
54response to inactivity (GO:0014854)3.76068654
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.74407959
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.64649362
57regulation of synapse maturation (GO:0090128)3.63182141
58transmission of nerve impulse (GO:0019226)3.61684279
59detection of calcium ion (GO:0005513)3.61103547
60long-term memory (GO:0007616)3.58730382
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56372446
62regulation of neurotransmitter levels (GO:0001505)3.56081526
63regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.50594411
64membrane hyperpolarization (GO:0060081)3.49197616
65neuron recognition (GO:0008038)3.49035568
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47904824
67ATP hydrolysis coupled proton transport (GO:0015991)3.45720911
68energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.45720911
69skeletal muscle tissue regeneration (GO:0043403)3.43200840
70presynaptic membrane organization (GO:0097090)3.40816414
71long-term synaptic potentiation (GO:0060291)3.38031183
72membrane depolarization (GO:0051899)3.36661846
73positive regulation of synapse assembly (GO:0051965)3.35766790
74regulation of synaptic plasticity (GO:0048167)3.35313109
75regulation of synaptic transmission, GABAergic (GO:0032228)3.34348617
76DNA deamination (GO:0045006)3.34303421
77synapse assembly (GO:0007416)3.34071772
78sulfation (GO:0051923)3.33750679
79positive regulation of neurotransmitter transport (GO:0051590)3.33271229
80regulation of synapse structural plasticity (GO:0051823)3.30822363
81learning (GO:0007612)3.28806843
82regulation of neurotransmitter secretion (GO:0046928)3.27869104
83indole-containing compound metabolic process (GO:0042430)3.25783266
84protein K11-linked deubiquitination (GO:0035871)3.25166783
85behavioral response to cocaine (GO:0048148)3.25078259
86striatum development (GO:0021756)3.22436381
87neuronal ion channel clustering (GO:0045161)3.18279651
88DNA methylation involved in gamete generation (GO:0043046)3.16997614
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16811415
90regulation of vesicle fusion (GO:0031338)3.16773006
91intraspecies interaction between organisms (GO:0051703)3.15862320
92social behavior (GO:0035176)3.15862320
93synaptic transmission (GO:0007268)3.15494405
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15397906
95regulation of synapse assembly (GO:0051963)3.09925729
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.09875969
97transferrin transport (GO:0033572)3.09715523
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07022126
99regulation of neurotransmitter transport (GO:0051588)3.06140528
100male meiosis I (GO:0007141)3.05680319
101positive regulation of synaptic transmission (GO:0050806)3.04527975
102cerebellar Purkinje cell differentiation (GO:0021702)3.03238375
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02749501
104neuromuscular process controlling posture (GO:0050884)3.02074025
105regulation of dendritic spine morphogenesis (GO:0061001)3.01448212
106negative regulation of sodium ion transport (GO:0010766)3.01129438
107trivalent inorganic cation transport (GO:0072512)3.00594403
108ferric iron transport (GO:0015682)3.00594403
109synaptic vesicle endocytosis (GO:0048488)3.00448733
110regulation of synaptic transmission (GO:0050804)2.99966414
111amine catabolic process (GO:0009310)2.99106349
112cellular biogenic amine catabolic process (GO:0042402)2.99106349
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98619152
114layer formation in cerebral cortex (GO:0021819)2.97821355
115membrane depolarization during action potential (GO:0086010)2.97078755
116positive regulation of action potential (GO:0045760)2.95484493
117piRNA metabolic process (GO:0034587)2.94954430
118regulation of female receptivity (GO:0045924)2.93969897
119behavioral response to ethanol (GO:0048149)2.93886579
120visual learning (GO:0008542)2.92978360
121positive regulation of phosphatase activity (GO:0010922)2.92682638
122neural tube formation (GO:0001841)2.90295793
123positive regulation of neurotransmitter secretion (GO:0001956)2.89557792
124positive regulation of developmental pigmentation (GO:0048087)2.89082889
125positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88877565
126preassembly of GPI anchor in ER membrane (GO:0016254)2.88787861
127learning or memory (GO:0007611)2.85252457
128memory (GO:0007613)2.84892762
129synapse organization (GO:0050808)2.84827747
130somite development (GO:0061053)2.84295912
131protein K63-linked deubiquitination (GO:0070536)2.84132570
132multicellular organismal movement (GO:0050879)2.83680231
133musculoskeletal movement (GO:0050881)2.83680231
134negative regulation of systemic arterial blood pressure (GO:0003085)2.83560971
135regulation of skeletal muscle contraction (GO:0014819)2.81571475
136detection of light stimulus involved in visual perception (GO:0050908)2.81436024
137detection of light stimulus involved in sensory perception (GO:0050962)2.81436024
138retinal cone cell development (GO:0046549)2.80587452
139response to histamine (GO:0034776)2.79892737
140establishment of synaptic vesicle localization (GO:0097480)2.79590694
141synaptic vesicle transport (GO:0048489)2.79590694
142regulation of dendritic spine development (GO:0060998)2.79387655
143negative regulation of dendrite morphogenesis (GO:0050774)2.79090410
144axoneme assembly (GO:0035082)2.78812065
145regulation of germinal center formation (GO:0002634)2.78785645
146positive regulation of oligodendrocyte differentiation (GO:0048714)2.78729812
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77748754
148cellular response to dexamethasone stimulus (GO:0071549)2.77456087
149B cell receptor signaling pathway (GO:0050853)2.74756248
150regulation of pigment cell differentiation (GO:0050932)2.74373422
151serotonin metabolic process (GO:0042428)2.73408359
152skeletal muscle adaptation (GO:0043501)2.71905429
153protein polyglutamylation (GO:0018095)2.68411780
154primary amino compound metabolic process (GO:1901160)2.64638578
155regulation of hippo signaling (GO:0035330)2.60489430
156photoreceptor cell maintenance (GO:0045494)2.60332426
157negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59278062
158microtubule anchoring (GO:0034453)2.58691119
159regulation of sarcomere organization (GO:0060297)2.58081620
160snRNA transcription (GO:0009301)2.53367115
161neuronal action potential (GO:0019228)2.53353878
162NAD biosynthetic process (GO:0009435)2.52549349
163nucleus localization (GO:0051647)2.51266426
164limb development (GO:0060173)2.51056157
165appendage development (GO:0048736)2.51056157
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50195270
167water-soluble vitamin biosynthetic process (GO:0042364)2.48674039
168cellular response to interleukin-15 (GO:0071350)2.48556869
169tachykinin receptor signaling pathway (GO:0007217)2.48457479
170protein K48-linked deubiquitination (GO:0071108)2.47982420
171regulation of sequestering of triglyceride (GO:0010889)2.47414580
172regulation of acrosome reaction (GO:0060046)2.47316167
173response to dexamethasone (GO:0071548)2.46976069
174male meiosis (GO:0007140)2.46809412
175multicellular organism reproduction (GO:0032504)2.46419881
176double-strand break repair via homologous recombination (GO:0000724)2.44275703
177response to pheromone (GO:0019236)2.44145370
178epithelial cilium movement (GO:0003351)2.43893963
179negative regulation of calcium ion transport into cytosol (GO:0010523)2.43298462
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42981028
181response to caffeine (GO:0031000)2.42856940
182establishment of protein localization to Golgi (GO:0072600)2.41651573
183photoreceptor cell development (GO:0042461)2.40681255
184benzene-containing compound metabolic process (GO:0042537)2.40301972
185glycosphingolipid biosynthetic process (GO:0006688)2.39327708
186positive regulation of cardiac muscle cell differentiation (GO:2000727)2.39232732
187rhodopsin mediated signaling pathway (GO:0016056)2.37990249
188recombinational repair (GO:0000725)2.37436341
189phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.37323629
190positive regulation of myoblast differentiation (GO:0045663)2.36306648
191regulation of meiosis I (GO:0060631)2.36032577
192detection of mechanical stimulus involved in sensory perception (GO:0050974)2.36025129
193platelet dense granule organization (GO:0060155)2.35862981
194reflex (GO:0060004)2.35611110
195meiosis I (GO:0007127)2.35119311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29685003
2GBX2_23144817_ChIP-Seq_PC3_Human4.43007002
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11698515
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01460554
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93949536
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60244536
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48937320
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48937320
9TAF15_26573619_Chip-Seq_HEK293_Human2.48559665
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45531552
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41843461
12REST_21632747_ChIP-Seq_MESCs_Mouse2.37959151
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36982690
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29543569
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.27795709
16* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26573889
17VDR_22108803_ChIP-Seq_LS180_Human2.25194340
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23252149
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.17860323
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13988660
21DROSHA_22980978_ChIP-Seq_HELA_Human2.13155500
22AR_21572438_ChIP-Seq_LNCaP_Human2.12153113
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.10824991
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05206340
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00646007
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98378792
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97997104
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.92484901
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91557452
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90001807
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89914865
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89507596
33P300_19829295_ChIP-Seq_ESCs_Human1.88243223
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.86594364
35* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81136001
36EWS_26573619_Chip-Seq_HEK293_Human1.77665456
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.76187626
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.75065192
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73050030
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72296258
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.71727656
42FUS_26573619_Chip-Seq_HEK293_Human1.71382845
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70505155
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69324699
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68733457
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68414827
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.67691830
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.66484140
49* NFE2_27457419_Chip-Seq_LIVER_Mouse1.66094273
50* EZH2_27294783_Chip-Seq_NPCs_Mouse1.62341996
51IGF1R_20145208_ChIP-Seq_DFB_Human1.60429243
52* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54053713
53IRF1_19129219_ChIP-ChIP_H3396_Human1.54001260
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52657949
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.51544309
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50984725
57* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49882927
58CBP_20019798_ChIP-Seq_JUKART_Human1.49624493
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49624493
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48612326
61TP53_16413492_ChIP-PET_HCT116_Human1.48611946
62AR_25329375_ChIP-Seq_VCAP_Human1.47999713
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44275561
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.41454698
65STAT3_23295773_ChIP-Seq_U87_Human1.40909232
66ER_23166858_ChIP-Seq_MCF-7_Human1.40233472
67* RNF2_27304074_Chip-Seq_NSC_Mouse1.38582085
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38249082
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37234268
70* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36987555
71ZNF274_21170338_ChIP-Seq_K562_Hela1.36726594
72* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35290324
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35158627
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34341112
75* CRX_20693478_ChIP-Seq_RETINA_Mouse1.34129472
76* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32489387
77* FLI1_27457419_Chip-Seq_LIVER_Mouse1.32058496
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31938129
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30315005
80TCF4_23295773_ChIP-Seq_U87_Human1.30114905
81* NANOG_18555785_Chip-Seq_ESCs_Mouse1.29963783
82* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29953839
83* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29566209
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29067002
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.28964522
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.28486258
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28313024
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.27431326
89* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26597908
90TP53_22573176_ChIP-Seq_HFKS_Human1.26051087
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26035961
92* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26035067
93* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24671586
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23580588
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21791141
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20411737
97* E2F1_18555785_Chip-Seq_ESCs_Mouse1.19919542
98* NANOG_19829295_ChIP-Seq_ESCs_Human1.17669802
99* SOX2_19829295_ChIP-Seq_ESCs_Human1.17669802
100* P53_22387025_ChIP-Seq_ESCs_Mouse1.17547644
101RUNX2_22187159_ChIP-Seq_PCA_Human1.17454400
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.16234803
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15927596
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15589281
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15080797
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.14630186
107* P300_18555785_Chip-Seq_ESCs_Mouse1.14047629
108TCF4_22108803_ChIP-Seq_LS180_Human1.13339047
109* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12918608
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12663473
111* STAT3_18555785_Chip-Seq_ESCs_Mouse1.12012359
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11607881
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11607881
114* CMYC_18555785_Chip-Seq_ESCs_Mouse1.10907563
115TP53_18474530_ChIP-ChIP_U2OS_Human1.10629921
116* KDM2B_26808549_Chip-Seq_REH_Human1.10535531
117AR_19668381_ChIP-Seq_PC3_Human1.10248468
118BCAT_22108803_ChIP-Seq_LS180_Human1.09932811
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09677397
120CDX2_22108803_ChIP-Seq_LS180_Human1.09652680
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09083359
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.08739771
123* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08377133
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08260946
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07007392
126* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06976479
127* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06046584
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05564426
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05462592
130* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05247731
131* RING1B_27294783_Chip-Seq_ESCs_Mouse1.04587028
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04583521
133* OCT4_18555785_Chip-Seq_ESCs_Mouse1.04496879
134JUN_21703547_ChIP-Seq_K562_Human1.04265736
135* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04194354
136P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04183018
137AHR_22903824_ChIP-Seq_MCF-7_Human1.04145686
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03392355
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02671729
140* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02047553
141RUNX_20019798_ChIP-Seq_JUKART_Human1.01816478
142* SOX2_18555785_Chip-Seq_ESCs_Mouse1.01278818
143HTT_18923047_ChIP-ChIP_STHdh_Human0.99111541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.73844793
2MP0003635_abnormal_synaptic_transmissio4.21381928
3MP0003880_abnormal_central_pattern4.12414152
4MP0009046_muscle_twitch3.93154277
5MP0009745_abnormal_behavioral_response3.50196983
6MP0002064_seizures3.46585447
7MP0004270_analgesia3.45574775
8MP0005670_abnormal_white_adipose3.43071369
9MP0002063_abnormal_learning/memory/cond3.27063213
10MP0002735_abnormal_chemical_nociception3.24209332
11MP0001501_abnormal_sleep_pattern2.98261499
12MP0002572_abnormal_emotion/affect_behav2.95954967
13MP0001968_abnormal_touch/_nociception2.94585817
14MP0002734_abnormal_mechanical_nocicepti2.89981720
15MP0002272_abnormal_nervous_system2.85677729
16MP0008057_abnormal_DNA_replication2.77068701
17MP0002822_catalepsy2.74443349
18MP0001486_abnormal_startle_reflex2.74307460
19MP0002138_abnormal_hepatobiliary_system2.69961083
20MP0005174_abnormal_tail_pigmentation2.60017984
21MP0002736_abnormal_nociception_after2.45276485
22MP0006292_abnormal_olfactory_placode2.37239285
23MP0002067_abnormal_sensory_capabilities2.23034772
24MP0003879_abnormal_hair_cell2.20920927
25MP0008569_lethality_at_weaning2.13702061
26MP0000372_irregular_coat_pigmentation2.08143419
27MP0002733_abnormal_thermal_nociception2.08047618
28MP0003195_calcinosis2.07294186
29MP0002876_abnormal_thyroid_physiology2.06162851
30MP0003787_abnormal_imprinting2.04399828
31MP0005645_abnormal_hypothalamus_physiol1.97477641
32MP0001440_abnormal_grooming_behavior1.96298013
33MP0001970_abnormal_pain_threshold1.92703884
34MP0002184_abnormal_innervation1.88475979
35MP0005646_abnormal_pituitary_gland1.87587238
36MP0005423_abnormal_somatic_nervous1.85111519
37MP0002557_abnormal_social/conspecific_i1.83176344
38MP0000015_abnormal_ear_pigmentation1.79024701
39MP0006276_abnormal_autonomic_nervous1.73311963
40MP0005386_behavior/neurological_phenoty1.65008552
41MP0004924_abnormal_behavior1.65008552
42MP0004130_abnormal_muscle_cell1.61406836
43MP0002095_abnormal_skin_pigmentation1.59733460
44MP0001188_hyperpigmentation1.57122284
45MP0001984_abnormal_olfaction1.50421953
46MP0009780_abnormal_chondrocyte_physiolo1.49724069
47MP0004811_abnormal_neuron_physiology1.45756674
48MP0004510_myositis1.41662662
49* MP0002066_abnormal_motor_capabilities/c1.39837372
50MP0004142_abnormal_muscle_tone1.33178492
51MP0000778_abnormal_nervous_system1.32898127
52MP0005253_abnormal_eye_physiology1.32416729
53MP0002837_dystrophic_cardiac_calcinosis1.31438877
54MP0005671_abnormal_response_to1.30720559
55MP0005389_reproductive_system_phenotype1.29565948
56MP0001502_abnormal_circadian_rhythm1.27362499
57MP0002882_abnormal_neuron_morphology1.26463259
58MP0004381_abnormal_hair_follicle1.25728324
59MP0000751_myopathy1.25639220
60MP0000383_abnormal_hair_follicle1.23757328
61MP0001963_abnormal_hearing_physiology1.23210612
62MP0000955_abnormal_spinal_cord1.22900658
63MP0004858_abnormal_nervous_system1.21447471
64MP0005075_abnormal_melanosome_morpholog1.21068724
65MP0004484_altered_response_of1.20505069
66MP0003136_yellow_coat_color1.20457683
67MP0001800_abnormal_humoral_immune1.18538857
68MP0004145_abnormal_muscle_electrophysio1.17294775
69MP0002938_white_spotting1.15500101
70MP0004742_abnormal_vestibular_system1.14399876
71MP0010386_abnormal_urinary_bladder1.13966320
72MP0001986_abnormal_taste_sensitivity1.12979807
73MP0001529_abnormal_vocalization1.07494995
74MP0003329_amyloid_beta_deposits1.06559738
75MP0000427_abnormal_hair_cycle1.04318475
76MP0003724_increased_susceptibility_to1.02313104
77MP0005551_abnormal_eye_electrophysiolog1.01417026
78MP0004215_abnormal_myocardial_fiber1.00883594
79MP0001905_abnormal_dopamine_level1.00702729
80MP0003646_muscle_fatigue0.99547576
81MP0002928_abnormal_bile_duct0.98083721
82MP0002638_abnormal_pupillary_reflex0.97915556
83MP0003633_abnormal_nervous_system0.97704572
84MP0003763_abnormal_thymus_physiology0.93758902
85MP0001177_atelectasis0.93419871
86MP0008775_abnormal_heart_ventricle0.92447215
87MP0003631_nervous_system_phenotype0.92337940
88MP0001790_abnormal_immune_system0.90623579
89MP0005387_immune_system_phenotype0.90623579
90MP0008874_decreased_physiological_sensi0.90489806
91MP0001919_abnormal_reproductive_system0.90322549
92MP0003122_maternal_imprinting0.89711893
93MP0004043_abnormal_pH_regulation0.89381718
94MP0000685_abnormal_immune_system0.88259171
95MP0008872_abnormal_physiological_respon0.88021191
96MP0002152_abnormal_brain_morphology0.87420509
97MP0000613_abnormal_salivary_gland0.87209949
98MP0002229_neurodegeneration0.85863296
99MP0008877_abnormal_DNA_methylation0.85862266
100MP0002108_abnormal_muscle_morphology0.85449748
101MP0005310_abnormal_salivary_gland0.83949601
102MP0004084_abnormal_cardiac_muscle0.83653074
103MP0003183_abnormal_peptide_metabolism0.83555797
104MP0001485_abnormal_pinna_reflex0.80754926
105* MP0002069_abnormal_eating/drinking_beha0.80226100
106MP0005620_abnormal_muscle_contractility0.80042371
107MP0000013_abnormal_adipose_tissue0.79727377
108MP0002909_abnormal_adrenal_gland0.79208549
109MP0000026_abnormal_inner_ear0.79020842
110MP0004885_abnormal_endolymph0.76529664
111MP0002653_abnormal_ependyma_morphology0.76009606
112MP0002752_abnormal_somatic_nervous0.75616933
113MP0000569_abnormal_digit_pigmentation0.75303001
114MP0008789_abnormal_olfactory_epithelium0.74908058
115MP0001835_abnormal_antigen_presentation0.74245891
116MP0005535_abnormal_body_temperature0.74242695
117MP0004085_abnormal_heartbeat0.71939783
118MP0003632_abnormal_nervous_system0.71413648
119MP0000371_diluted_coat_color0.71251378
120MP0000631_abnormal_neuroendocrine_gland0.70622272
121MP0003698_abnormal_male_reproductive0.69460635
122MP0005367_renal/urinary_system_phenotyp0.69439420
123MP0000516_abnormal_urinary_system0.69439420
124MP0005266_abnormal_metabolism0.69352193
125MP0002723_abnormal_immune_serum0.69347168
126MP0005171_absent_coat_pigmentation0.69205984
127MP0002163_abnormal_gland_morphology0.68501941
128MP0002106_abnormal_muscle_physiology0.68330100
129MP0000230_abnormal_systemic_arterial0.67848449
130MP0002090_abnormal_vision0.65318409
131MP0005410_abnormal_fertilization0.65193418
132MP0001661_extended_life_span0.64847011
133MP0000749_muscle_degeneration0.63534112
134MP0009053_abnormal_anal_canal0.63493332
135MP0003252_abnormal_bile_duct0.62737717
136MP0003950_abnormal_plasma_membrane0.62732239
137MP0005000_abnormal_immune_tolerance0.62699642
138MP0003137_abnormal_impulse_conducting0.62615289
139MP0001664_abnormal_digestion0.59669559
140MP0002160_abnormal_reproductive_system0.56697270
141MP0002332_abnormal_exercise_endurance0.55300885
142MP0003634_abnormal_glial_cell0.54296954
143MP0001943_abnormal_respiration0.52080772
144MP0003690_abnormal_glial_cell0.49674001
145MP0002102_abnormal_ear_morphology0.48444079
146* MP0010769_abnormal_survival0.46908680
147MP0004233_abnormal_muscle_weight0.46078816
148* MP0002082_postnatal_lethality0.46052573
149* MP0010770_preweaning_lethality0.46052573
150MP0003045_fibrosis0.45443110
151* MP0003956_abnormal_body_size0.45392620
152MP0005379_endocrine/exocrine_gland_phen0.44790883

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.49004783
2Atonic seizures (HP:0010819)6.44861362
3Febrile seizures (HP:0002373)6.28787037
4Epileptic encephalopathy (HP:0200134)5.94223289
5Focal seizures (HP:0007359)5.86192509
6Myokymia (HP:0002411)5.80905818
7Absence seizures (HP:0002121)4.76725219
8Visual hallucinations (HP:0002367)4.74735165
9Progressive cerebellar ataxia (HP:0002073)4.48481664
10Hyperventilation (HP:0002883)4.47167540
11Generalized tonic-clonic seizures (HP:0002069)4.39043989
12Progressive inability to walk (HP:0002505)4.32722246
13Dialeptic seizures (HP:0011146)4.16181859
14Gaze-evoked nystagmus (HP:0000640)3.93024620
15Broad-based gait (HP:0002136)3.73014838
16Congenital sensorineural hearing impairment (HP:0008527)3.64836160
17Popliteal pterygium (HP:0009756)3.57770519
18Pancreatic cysts (HP:0001737)3.38929262
19Aplasia of the musculature (HP:0100854)3.33608793
20Abnormal hair whorl (HP:0010721)3.21843679
21Inability to walk (HP:0002540)3.21471623
22Dysdiadochokinesis (HP:0002075)3.20404073
23Absent speech (HP:0001344)3.15424469
24Abnormal social behavior (HP:0012433)3.10434813
25Impaired social interactions (HP:0000735)3.10434813
26Action tremor (HP:0002345)3.06094733
27Type 2 muscle fiber atrophy (HP:0003554)3.05621034
28Abnormality of binocular vision (HP:0011514)3.04799214
29Diplopia (HP:0000651)3.04799214
30Truncal ataxia (HP:0002078)2.99764642
31Acute necrotizing encephalopathy (HP:0006965)2.97968269
32Aplasia/Hypoplasia involving the musculature (HP:0001460)2.97348936
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95658130
34Agammaglobulinemia (HP:0004432)2.91953756
35Attenuation of retinal blood vessels (HP:0007843)2.90748106
36Fetal akinesia sequence (HP:0001989)2.89167244
37Scanning speech (HP:0002168)2.85526294
38Pancreatic fibrosis (HP:0100732)2.84493293
39Keratoconus (HP:0000563)2.82034225
40Increased corneal curvature (HP:0100692)2.82034225
41Abnormal mitochondria in muscle tissue (HP:0008316)2.79305651
42Poor eye contact (HP:0000817)2.77822410
43Status epilepticus (HP:0002133)2.76588640
44Chronic hepatic failure (HP:0100626)2.76331610
45Congenital stationary night blindness (HP:0007642)2.75576500
46Abnormality of the renal cortex (HP:0011035)2.73427429
47Progressive macrocephaly (HP:0004481)2.71956857
48Impaired vibration sensation in the lower limbs (HP:0002166)2.71388051
49Abnormal eating behavior (HP:0100738)2.70669764
50Excessive salivation (HP:0003781)2.57895381
51Drooling (HP:0002307)2.57895381
52Stomach cancer (HP:0012126)2.56558520
53True hermaphroditism (HP:0010459)2.56301264
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.56100176
55Gait imbalance (HP:0002141)2.52133735
56Generalized myoclonic seizures (HP:0002123)2.50791590
57Malignant hyperthermia (HP:0002047)2.45385001
58Anxiety (HP:0000739)2.45282929
59Polyphagia (HP:0002591)2.44283181
60Long clavicles (HP:0000890)2.43029439
61Amblyopia (HP:0000646)2.42301453
62Recurrent sinusitis (HP:0011108)2.41896445
63Abolished electroretinogram (ERG) (HP:0000550)2.40603678
64Dysmetria (HP:0001310)2.40538765
65Depression (HP:0000716)2.40458893
66Tubulointerstitial nephritis (HP:0001970)2.40124552
67Ankle clonus (HP:0011448)2.39916995
68Abnormality of the renal medulla (HP:0100957)2.38935200
69Epileptiform EEG discharges (HP:0011182)2.35494717
70Nonprogressive disorder (HP:0003680)2.34620313
71Hemiparesis (HP:0001269)2.34270996
72Papilledema (HP:0001085)2.33798254
73Nephronophthisis (HP:0000090)2.33757461
74Urinary bladder sphincter dysfunction (HP:0002839)2.33061552
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32294125
76Abnormality of alanine metabolism (HP:0010916)2.32294125
77Hyperalaninemia (HP:0003348)2.32294125
78Methylmalonic acidemia (HP:0002912)2.31166126
79Absent phalangeal crease (HP:0006109)2.30626492
80Bony spicule pigmentary retinopathy (HP:0007737)2.26175158
81Abnormality of B cell number (HP:0010975)2.25163315
82Tubular atrophy (HP:0000092)2.25052723
83Mitochondrial inheritance (HP:0001427)2.24832381
84Medial flaring of the eyebrow (HP:0010747)2.21906758
85Lower limb amyotrophy (HP:0007210)2.21783033
86Muscle fiber atrophy (HP:0100295)2.21687771
87Congenital primary aphakia (HP:0007707)2.21595890
88Abnormality of placental membranes (HP:0011409)2.20509286
89Amniotic constriction ring (HP:0009775)2.20509286
90Protruding tongue (HP:0010808)2.20258940
91Abnormality of the neuromuscular junction (HP:0003398)2.19972807
92Fatigable weakness (HP:0003473)2.19972807
93Acute encephalopathy (HP:0006846)2.19269491
94Morphological abnormality of the middle ear (HP:0008609)2.18330592
95Abnormality of midbrain morphology (HP:0002418)2.17440505
96Molar tooth sign on MRI (HP:0002419)2.17440505
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.17221658
98EEG with generalized epileptiform discharges (HP:0011198)2.17137869
99Akinesia (HP:0002304)2.15595794
100Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.15574431
101Short 1st metacarpal (HP:0010034)2.15574431
102Tubulointerstitial abnormality (HP:0001969)2.15334712
103Mutism (HP:0002300)2.14668812
104Esotropia (HP:0000565)2.14421441
105Symphalangism affecting the phalanges of the hand (HP:0009773)2.13950283
106Methylmalonic aciduria (HP:0012120)2.12859891
107Hemiplegia (HP:0002301)2.12421498
108Pendular nystagmus (HP:0012043)2.10649260
109Colon cancer (HP:0003003)2.09967303
110Enlarged kidneys (HP:0000105)2.08309663
111Impaired vibratory sensation (HP:0002495)2.06034343
112Blue irides (HP:0000635)2.04848632
113Abnormality of the nasal septum (HP:0000419)2.04266412
114Abnormal finger flexion creases (HP:0006143)2.03585026
115Hip dysplasia (HP:0001385)2.03293986
116Absent/shortened dynein arms (HP:0200106)2.02799992
117Dynein arm defect of respiratory motile cilia (HP:0012255)2.02799992
118Nephrogenic diabetes insipidus (HP:0009806)2.02273707
119Pheochromocytoma (HP:0002666)2.01556293
120Hypsarrhythmia (HP:0002521)2.01132936
121Horizontal nystagmus (HP:0000666)2.00763660
122Carpal bone hypoplasia (HP:0001498)2.00432951
123Abnormal rod and cone electroretinograms (HP:0008323)2.00141223
124Genetic anticipation (HP:0003743)1.99468145
125Recurrent bronchitis (HP:0002837)1.97516482
126Fair hair (HP:0002286)1.96964186
127Chorioretinal atrophy (HP:0000533)1.96420953
128Hematochezia (HP:0002573)1.96173995
129Panhypogammaglobulinemia (HP:0003139)1.93761119
130Abnormality of the renal collecting system (HP:0004742)1.93726677
131Specific learning disability (HP:0001328)1.93583400
132Cystic liver disease (HP:0006706)1.93533979
133Impaired smooth pursuit (HP:0007772)1.93504336
134Cutaneous finger syndactyly (HP:0010554)1.92662123
135Nemaline bodies (HP:0003798)1.92275399
136Constricted visual fields (HP:0001133)1.91587292
137Stereotypic behavior (HP:0000733)1.91532889
138Decreased central vision (HP:0007663)1.90676214
139IgG deficiency (HP:0004315)1.90667414
140Generalized hypopigmentation of hair (HP:0011358)1.89784510
141Vaginal atresia (HP:0000148)1.89325503
142Optic disc pallor (HP:0000543)1.89144569
143Abnormality of DNA repair (HP:0003254)1.85979413
144Genital tract atresia (HP:0001827)1.85960000
145Abnormality of salivation (HP:0100755)1.84883539
146Abnormality of the 1st metacarpal (HP:0010009)1.84845390
147Neuroendocrine neoplasm (HP:0100634)1.84355713
148Bradykinesia (HP:0002067)1.83811504
149Thyroiditis (HP:0100646)1.81443030
150Distal arthrogryposis (HP:0005684)1.79910473
151Hypoplastic ischia (HP:0003175)1.79874116
152Clumsiness (HP:0002312)1.79833102
153Failure to thrive in infancy (HP:0001531)1.79390431
154Spastic gait (HP:0002064)1.79312233
155Resting tremor (HP:0002322)1.78756442
156Abnormality of the ischium (HP:0003174)1.78704268
157Gait ataxia (HP:0002066)1.78435293
158Ectopic kidney (HP:0000086)1.78257335
159Abnormal ciliary motility (HP:0012262)1.78237304
160Abnormality of ocular smooth pursuit (HP:0000617)1.78218244
161Retinal dysplasia (HP:0007973)1.74978854
162Short tibia (HP:0005736)1.74320460
163Abnormality of chromosome stability (HP:0003220)1.74111748
164Gowers sign (HP:0003391)1.74060447
165Postural instability (HP:0002172)1.72956738
166Small hand (HP:0200055)1.72821245
167X-linked dominant inheritance (HP:0001423)1.72037315
168Cutaneous syndactyly (HP:0012725)1.71992888
169Increased CSF lactate (HP:0002490)1.70928259
170Spastic tetraplegia (HP:0002510)1.70617439
171Hypoplastic iliac wings (HP:0002866)1.70508652
172Calf muscle hypertrophy (HP:0008981)1.70328048
173Lissencephaly (HP:0001339)1.70118050
174Lipid accumulation in hepatocytes (HP:0006561)1.69470492
175Intention tremor (HP:0002080)1.69456213
176Narrow nasal bridge (HP:0000446)1.66881003
177Psychosis (HP:0000709)1.66710167
178Cortical visual impairment (HP:0100704)1.66663706
179Poor suck (HP:0002033)1.66244245
180Widely spaced teeth (HP:0000687)1.65151500
181Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64905837
182Supranuclear gaze palsy (HP:0000605)1.61654930
183Poor coordination (HP:0002370)1.60352565
184Distal lower limb amyotrophy (HP:0008944)1.59885559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.73867915
2MAP2K74.07333239
3NTRK34.06144572
4MAP3K43.91759877
5CASK3.85820922
6MUSK3.23217232
7MAP3K123.21204471
8MAP3K92.83497281
9PDK22.78589733
10EPHA42.67479330
11BRD42.64696688
12TNIK2.63652216
13ADRBK22.56031910
14GRK12.54358670
15MAP2K42.33890273
16MINK12.25288253
17PIK3CG2.14701619
18MARK12.13923665
19DAPK22.11793994
20NTRK22.06770833
21PNCK1.98834581
22TAOK31.91063127
23CDK191.89554000
24STK38L1.87396807
25ZAK1.86453320
26CAMKK21.79610790
27PLK21.74701860
28DAPK11.74196166
29ACVR1B1.70050218
30NTRK11.64435460
31MAP4K21.58849641
32NUAK11.56905871
33CAMKK11.54769665
34PRPF4B1.54332255
35PAK61.50404088
36TLK11.43185377
37EIF2AK31.41122119
38MAP3K61.39820705
39STK391.38665199
40CCNB11.35627703
41GRK51.35317047
42NLK1.34196012
43TEC1.33923454
44MAPK131.30172138
45CDK51.29725732
46RIPK41.26146653
47MAP2K21.24444281
48CDK81.22251305
49MAP2K11.19738859
50FES1.16102385
51NME11.15976796
52BMPR21.14649746
53SYK1.13515184
54OXSR11.12547073
55IKBKE1.11799573
56ERBB41.11573970
57ARAF1.09170406
58PRKCG1.05570552
59AKT31.05447035
60CAMK2A1.04225719
61CAMK11.01620601
62BMPR1B0.97870436
63INSRR0.97432753
64CSNK1A1L0.97225267
65TNK20.96177096
66CAMK1G0.95249413
67TXK0.93748277
68SGK20.91729867
69STK380.89837330
70CSNK1G10.87096741
71KSR10.85390713
72BLK0.84419857
73PRKCE0.83616560
74IKBKB0.82702365
75MAP4K10.81784975
76WNK30.80220876
77TRIM280.79900128
78STK110.79522391
79MST40.78736237
80FER0.77162730
81SGK2230.75712069
82SGK4940.75712069
83CSNK1G30.74183051
84SIK20.73772155
85KSR20.73764686
86RPS6KB10.70848340
87LATS20.70685902
88PRKCQ0.69592876
89DYRK1A0.69568417
90MKNK20.68727384
91SGK10.68590729
92ABL10.67379949
93MARK30.63378312
94STK30.62328765
95LMTK20.61972671
96CAMK2B0.60366592
97RPS6KA50.60194945
98MAPK70.59185923
99BTK0.58111646
100HCK0.57965260
101CSF1R0.57357212
102KIT0.57123351
103CDK180.56677149
104LYN0.55862034
105MAPKAPK30.54839702
106PINK10.54609760
107ITK0.53904859
108TSSK60.53358689
109MAPK120.52824201
110SIK30.52602478
111CDK150.52409334
112PDK10.52232268
113SGK30.51526384
114PHKG10.50140576
115PHKG20.50140576
116PRKD30.49669217
117MYLK0.49041261
118PIK3CA0.48977038
119PRKCH0.48787405
120MELK0.47307104
121PAK30.46628233
122CAMK40.46600729
123IRAK10.46527674
124BCR0.45371347
125RAF10.45161543
126ADRBK10.45025813
127CDK140.44871370
128MAP3K130.43930006
129BRAF0.43375633
130OBSCN0.43333767
131EPHA30.43290730
132PTK2B0.43173778
133VRK10.42897244
134CDK11A0.42230233
135UHMK10.42215588
136PRKACA0.41897252
137RET0.41555804
138CAMK2G0.40843885
139PDPK10.40672483
140PIM10.40006756
141TIE10.38550491
142MAP3K140.38118875
143RPS6KA30.36718729
144CSNK1A10.36655124
145CSNK1D0.36636498
146CSNK1G20.36494373
147MAP3K70.36430768
148PKN10.36141825
149CAMK2D0.35803721
150IRAK20.35623811
151DAPK30.33377775
152MOS0.31455417
153NEK60.31340148
154TYRO30.30659173
155ALK0.29999979
156PRKG10.29950163
157RPS6KA20.29370345
158PRKCB0.29165017

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.18463556
2Synaptic vesicle cycle_Homo sapiens_hsa047213.90489702
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.96493091
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.94143966
5Collecting duct acid secretion_Homo sapiens_hsa049662.83639974
6GABAergic synapse_Homo sapiens_hsa047272.82548208
7Asthma_Homo sapiens_hsa053102.80016287
8Graft-versus-host disease_Homo sapiens_hsa053322.71819900
9Primary immunodeficiency_Homo sapiens_hsa053402.71053559
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.65177810
11Olfactory transduction_Homo sapiens_hsa047402.62250334
12Morphine addiction_Homo sapiens_hsa050322.57235248
13Allograft rejection_Homo sapiens_hsa053302.52663063
14Glutamatergic synapse_Homo sapiens_hsa047242.49063225
15Circadian entrainment_Homo sapiens_hsa047132.48113784
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30368481
17Autoimmune thyroid disease_Homo sapiens_hsa053202.29701579
18Long-term potentiation_Homo sapiens_hsa047202.16174794
19Salivary secretion_Homo sapiens_hsa049702.08551992
20Taste transduction_Homo sapiens_hsa047421.99554825
21Amphetamine addiction_Homo sapiens_hsa050311.96640336
22Oxidative phosphorylation_Homo sapiens_hsa001901.94041330
23Homologous recombination_Homo sapiens_hsa034401.92529403
24Dopaminergic synapse_Homo sapiens_hsa047281.91943152
25Serotonergic synapse_Homo sapiens_hsa047261.77059940
26Nitrogen metabolism_Homo sapiens_hsa009101.75987159
27Insulin secretion_Homo sapiens_hsa049111.74229502
28Cholinergic synapse_Homo sapiens_hsa047251.67913123
29Calcium signaling pathway_Homo sapiens_hsa040201.65085251
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64698442
31Long-term depression_Homo sapiens_hsa047301.61153411
32Type I diabetes mellitus_Homo sapiens_hsa049401.59233711
33Systemic lupus erythematosus_Homo sapiens_hsa053221.57259782
34Vibrio cholerae infection_Homo sapiens_hsa051101.55087024
35Gastric acid secretion_Homo sapiens_hsa049711.54142248
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54134551
37Linoleic acid metabolism_Homo sapiens_hsa005911.52161565
38ABC transporters_Homo sapiens_hsa020101.51049427
39Viral myocarditis_Homo sapiens_hsa054161.50369091
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46776390
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43055690
42Oxytocin signaling pathway_Homo sapiens_hsa049211.42748177
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42041368
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40859600
45Renin secretion_Homo sapiens_hsa049241.37628163
46Alzheimers disease_Homo sapiens_hsa050101.37234306
47Cardiac muscle contraction_Homo sapiens_hsa042601.36753792
48Tryptophan metabolism_Homo sapiens_hsa003801.29263540
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28029487
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27878157
51Parkinsons disease_Homo sapiens_hsa050121.21607913
52Phototransduction_Homo sapiens_hsa047441.20890484
53Fanconi anemia pathway_Homo sapiens_hsa034601.17573847
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14714003
55Sulfur relay system_Homo sapiens_hsa041221.14326119
56Hematopoietic cell lineage_Homo sapiens_hsa046401.09833493
57cAMP signaling pathway_Homo sapiens_hsa040241.08986743
58GnRH signaling pathway_Homo sapiens_hsa049121.08763196
59Rheumatoid arthritis_Homo sapiens_hsa053231.07406834
60Ether lipid metabolism_Homo sapiens_hsa005651.06713054
61Antigen processing and presentation_Homo sapiens_hsa046121.06469111
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.05544683
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.03689940
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03461069
65Sulfur metabolism_Homo sapiens_hsa009201.02394173
66Cocaine addiction_Homo sapiens_hsa050301.02121651
67Glycerolipid metabolism_Homo sapiens_hsa005611.00726242
68Type II diabetes mellitus_Homo sapiens_hsa049300.98471847
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.96430223
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94972310
71Huntingtons disease_Homo sapiens_hsa050160.93833318
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93818616
73ErbB signaling pathway_Homo sapiens_hsa040120.93314134
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91712373
75Basal transcription factors_Homo sapiens_hsa030220.91481695
76Gap junction_Homo sapiens_hsa045400.90677577
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88972693
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88306981
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86416970
80RNA degradation_Homo sapiens_hsa030180.85509623
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80000110
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.78655456
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77265050
84Axon guidance_Homo sapiens_hsa043600.75777087
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75672629
86B cell receptor signaling pathway_Homo sapiens_hsa046620.75189103
87MAPK signaling pathway_Homo sapiens_hsa040100.74975646
88Staphylococcus aureus infection_Homo sapiens_hsa051500.74937621
89Selenocompound metabolism_Homo sapiens_hsa004500.74653940
90Estrogen signaling pathway_Homo sapiens_hsa049150.74217469
91Dilated cardiomyopathy_Homo sapiens_hsa054140.73843791
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72076016
93p53 signaling pathway_Homo sapiens_hsa041150.70313669
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66743801
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66580631
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65550760
97Arachidonic acid metabolism_Homo sapiens_hsa005900.65499157
98Glioma_Homo sapiens_hsa052140.64681800
99Ras signaling pathway_Homo sapiens_hsa040140.64512728
100African trypanosomiasis_Homo sapiens_hsa051430.63415043
101Butanoate metabolism_Homo sapiens_hsa006500.62201041
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61996806
103Chemical carcinogenesis_Homo sapiens_hsa052040.60539186
104Phagosome_Homo sapiens_hsa041450.59749083
105Retinol metabolism_Homo sapiens_hsa008300.59481871
106Melanogenesis_Homo sapiens_hsa049160.57210663
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56565671
108Pancreatic secretion_Homo sapiens_hsa049720.56427157
109Caffeine metabolism_Homo sapiens_hsa002320.56117871
110Platelet activation_Homo sapiens_hsa046110.56036011
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.56004207
112Dorso-ventral axis formation_Homo sapiens_hsa043200.55263461
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53018885
114Thyroid hormone synthesis_Homo sapiens_hsa049180.51873100
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.51639809
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51109331
117Non-homologous end-joining_Homo sapiens_hsa034500.50654732
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.48749618
119Choline metabolism in cancer_Homo sapiens_hsa052310.48257751
120Protein digestion and absorption_Homo sapiens_hsa049740.47883619
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47244131
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47229687
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46087546
124Melanoma_Homo sapiens_hsa052180.45932621
125Inositol phosphate metabolism_Homo sapiens_hsa005620.45535459
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45512404
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43883172
128Leishmaniasis_Homo sapiens_hsa051400.43299361
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42148256
130Oocyte meiosis_Homo sapiens_hsa041140.41776570
131Ovarian steroidogenesis_Homo sapiens_hsa049130.41639527
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41617016
133Rap1 signaling pathway_Homo sapiens_hsa040150.41027227
134Chemokine signaling pathway_Homo sapiens_hsa040620.39763905
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39480527
136Propanoate metabolism_Homo sapiens_hsa006400.38970138
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37920557
138Herpes simplex infection_Homo sapiens_hsa051680.35040469
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.32595836
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.30555564
141Glucagon signaling pathway_Homo sapiens_hsa049220.27824777
142beta-Alanine metabolism_Homo sapiens_hsa004100.26985805
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25228569
144Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22668769
145Pyruvate metabolism_Homo sapiens_hsa006200.21135605
146Alcoholism_Homo sapiens_hsa050340.20467960
147Prolactin signaling pathway_Homo sapiens_hsa049170.18733544
148Tuberculosis_Homo sapiens_hsa051520.18681177
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17770560
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17636274
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17340067
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17172988
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16921207
154Regulation of autophagy_Homo sapiens_hsa041400.16613840

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