COL11A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)9.44610351
2cell aggregation (GO:0098743)8.49284404
3cartilage condensation (GO:0001502)8.49284404
4chondrocyte development (GO:0002063)7.48811343
5keratan sulfate catabolic process (GO:0042340)7.24650850
6regulation of somitogenesis (GO:0014807)5.86914692
7auditory receptor cell differentiation (GO:0042491)5.65931093
8* collagen fibril organization (GO:0030199)5.62048987
9endocardial cushion morphogenesis (GO:0003203)5.59817605
10acrosome reaction (GO:0007340)5.35295187
11limb bud formation (GO:0060174)5.34035373
12regulation of extracellular matrix disassembly (GO:0010715)5.11152430
13* collagen catabolic process (GO:0030574)5.03527936
14* collagen metabolic process (GO:0032963)4.96314029
15replacement ossification (GO:0036075)4.90711019
16endochondral ossification (GO:0001958)4.90711019
17bone trabecula formation (GO:0060346)4.86819365
18notochord development (GO:0030903)4.77729127
19positive regulation of extracellular matrix organization (GO:1903055)4.71185570
20* multicellular organismal macromolecule metabolic process (GO:0044259)4.65082395
21enteric nervous system development (GO:0048484)4.60101931
22* multicellular organismal catabolic process (GO:0044243)4.59752881
23mesenchyme morphogenesis (GO:0072132)4.56693295
24fusion of sperm to egg plasma membrane (GO:0007342)4.51936605
25lipopolysaccharide biosynthetic process (GO:0009103)4.41660799
26pentose metabolic process (GO:0019321)4.40135883
27* multicellular organismal metabolic process (GO:0044236)4.35952222
28cell-cell junction maintenance (GO:0045217)4.31672546
29sperm capacitation (GO:0048240)4.30144628
30pathway-restricted SMAD protein phosphorylation (GO:0060389)4.10408932
31* cartilage development (GO:0051216)4.06973093
32locomotory exploration behavior (GO:0035641)4.06441766
33inner ear receptor cell differentiation (GO:0060113)4.06425152
34glycoprotein catabolic process (GO:0006516)4.04829825
35negative regulation of inclusion body assembly (GO:0090084)4.03704277
36sperm motility (GO:0030317)4.03492025
37proteoglycan metabolic process (GO:0006029)4.02069541
38chondrocyte proliferation (GO:0035988)3.90500875
39cell junction maintenance (GO:0034331)3.85202519
40chromosome condensation (GO:0030261)3.83406740
41iron ion import (GO:0097286)3.78334092
42embryonic skeletal joint morphogenesis (GO:0060272)3.77814233
43positive regulation of chondrocyte differentiation (GO:0032332)3.76621237
44axon ensheathment in central nervous system (GO:0032291)3.76575938
45central nervous system myelination (GO:0022010)3.76575938
46response to gravity (GO:0009629)3.74289677
47* extracellular matrix disassembly (GO:0022617)3.73642676
48postsynaptic membrane organization (GO:0001941)3.71477326
49chondroitin sulfate biosynthetic process (GO:0030206)3.68942674
50lipopolysaccharide metabolic process (GO:0008653)3.68856552
51* chondrocyte differentiation (GO:0002062)3.66605708
52type B pancreatic cell proliferation (GO:0044342)3.66036870
53negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.65867312
54negative regulation of catenin import into nucleus (GO:0035414)3.58440013
55keratan sulfate biosynthetic process (GO:0018146)3.56744619
56DNA packaging (GO:0006323)3.55152818
57calcium ion-dependent exocytosis (GO:0017156)3.51973915
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.51629250
59lateral sprouting from an epithelium (GO:0060601)3.50470920
60plasma membrane fusion (GO:0045026)3.49823840
61lens fiber cell development (GO:0070307)3.49233429
62melanin biosynthetic process (GO:0042438)3.46990713
63sodium ion export (GO:0071436)3.45899923
64regulation of cardioblast differentiation (GO:0051890)3.44967674
65heart valve morphogenesis (GO:0003179)3.44172334
66hair cell differentiation (GO:0035315)3.43915962
67regulation of extracellular matrix organization (GO:1903053)3.42873709
68positive regulation of cartilage development (GO:0061036)3.40558479
69positive regulation of hormone biosynthetic process (GO:0046886)3.36129115
70protein polyglutamylation (GO:0018095)3.32673841
71response to pheromone (GO:0019236)3.31413376
72mechanoreceptor differentiation (GO:0042490)3.28025545
73hypotonic response (GO:0006971)3.26973282
74regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24652275
75dermatan sulfate biosynthetic process (GO:0030208)3.23972257
76dermatan sulfate metabolic process (GO:0030205)3.22230870
77melanin metabolic process (GO:0006582)3.21697662
78connective tissue development (GO:0061448)3.19697833
79* skeletal system development (GO:0001501)3.19006278
80cellular component maintenance (GO:0043954)3.18990575
81microtubule polymerization or depolymerization (GO:0031109)3.17431700
82endothelial cell morphogenesis (GO:0001886)3.16959477
83protein heterotrimerization (GO:0070208)3.16946290
84protein retention in ER lumen (GO:0006621)3.13674135
85regulation of ARF GTPase activity (GO:0032312)3.12497500
86glycoprotein metabolic process (GO:0009100)3.11551510
87* sensory perception of sound (GO:0007605)3.10511625
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09237781
89outflow tract septum morphogenesis (GO:0003148)3.07925475
90regulation of inclusion body assembly (GO:0090083)3.07665594
91myofibril assembly (GO:0030239)3.07177015
92cellular response to BMP stimulus (GO:0071773)3.06310458
93response to BMP (GO:0071772)3.06310458
94peripheral nervous system development (GO:0007422)3.06243107
95regulation of chondrocyte differentiation (GO:0032330)3.06020421
96peptidyl-proline hydroxylation (GO:0019511)3.05600923
97* sensory perception of mechanical stimulus (GO:0050954)3.04699625
98cardiac myofibril assembly (GO:0055003)3.03271853
99positive regulation of odontogenesis (GO:0042482)3.00522110
100cellular sodium ion homeostasis (GO:0006883)3.00353758
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00184271
102histone H3-K9 demethylation (GO:0033169)2.99252040
103cell communication by electrical coupling (GO:0010644)2.99153460
104maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98922655
105* extracellular matrix organization (GO:0030198)2.98232549
106positive regulation of Rab GTPase activity (GO:0032851)2.97670269
107regulation of Rab GTPase activity (GO:0032313)2.97670269
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97467026
109sphingomyelin metabolic process (GO:0006684)2.97096450
110cardiac epithelial to mesenchymal transition (GO:0060317)2.97050196
111* extracellular structure organization (GO:0043062)2.96979371
112semaphorin-plexin signaling pathway (GO:0071526)2.96859163
113regulation of heart morphogenesis (GO:2000826)2.94288109
114microtubule severing (GO:0051013)2.94005888
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.93903465
116neuronal ion channel clustering (GO:0045161)2.92791990
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.92337073
118exploration behavior (GO:0035640)2.91301166
119heart valve formation (GO:0003188)2.91291714
120regulation of cartilage development (GO:0061035)2.87934718
121keratan sulfate metabolic process (GO:0042339)2.87637338
122dendritic spine organization (GO:0097061)2.87376693
123inner ear morphogenesis (GO:0042472)2.87203146
124spermatid development (GO:0007286)2.86329290
125multicellular organismal movement (GO:0050879)2.85794171
126musculoskeletal movement (GO:0050881)2.85794171
127negative regulation of chondrocyte differentiation (GO:0032331)2.85473279
128* ossification (GO:0001503)2.84581399
129cochlea morphogenesis (GO:0090103)2.83884821
130regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.83800434
131regulation of plasminogen activation (GO:0010755)2.83193527
132establishment of apical/basal cell polarity (GO:0035089)2.82316871
133chromatin silencing (GO:0006342)2.81252163
134regulation of cardioblast proliferation (GO:0003264)2.81044556
135regulation of secondary heart field cardioblast proliferation (GO:0003266)2.81044556
136skin morphogenesis (GO:0043589)2.80046298
137glycosaminoglycan biosynthetic process (GO:0006024)2.79420409
138oligodendrocyte differentiation (GO:0048709)2.79000864
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78260735
140negative regulation of cartilage development (GO:0061037)2.78237973
141spermatid nucleus differentiation (GO:0007289)2.76549619
142regulation of skeletal muscle cell differentiation (GO:2001014)2.75459196
143epithelial to mesenchymal transition (GO:0001837)2.74992802
144aminoglycan biosynthetic process (GO:0006023)2.74731939
145positive regulation of myotube differentiation (GO:0010831)2.74211470
146cranial nerve morphogenesis (GO:0021602)2.73232804
147outer ear morphogenesis (GO:0042473)2.73131188
148lung epithelium development (GO:0060428)2.72507570
149coronary vasculature morphogenesis (GO:0060977)2.70788097
150myelin assembly (GO:0032288)2.70598397
151proteoglycan biosynthetic process (GO:0030166)2.69568121
152chondroitin sulfate catabolic process (GO:0030207)2.68816699
153myelination in peripheral nervous system (GO:0022011)2.68661180
154peripheral nervous system axon ensheathment (GO:0032292)2.68661180
155secondary metabolite biosynthetic process (GO:0044550)2.68265074
156glial cell migration (GO:0008347)2.67814750
157basement membrane organization (GO:0071711)2.67406909
158microtubule depolymerization (GO:0007019)2.66927568
159epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66535608
160type B pancreatic cell development (GO:0003323)2.66361750
161Notch signaling involved in heart development (GO:0061314)2.66267686
162aorta morphogenesis (GO:0035909)2.65505738
163neurotransmitter-gated ion channel clustering (GO:0072578)2.65247070
164regulation of response to osmotic stress (GO:0047484)2.64605195
165actin-myosin filament sliding (GO:0033275)2.56381189
166muscle filament sliding (GO:0030049)2.56381189
167actin filament capping (GO:0051693)2.56274759
168nephron tubule formation (GO:0072079)2.55383752
169sarcomere organization (GO:0045214)2.54882595
170urinary tract smooth muscle contraction (GO:0014848)2.51907060
171nucleosome disassembly (GO:0006337)2.51102458
172protein-DNA complex disassembly (GO:0032986)2.51102458
173presynaptic membrane assembly (GO:0097105)2.50980937
174dendritic spine morphogenesis (GO:0060997)2.49395055
175cerebellar granule cell differentiation (GO:0021707)2.48344724
176neuromuscular process controlling balance (GO:0050885)2.47304159
177positive regulation of neuroblast proliferation (GO:0002052)2.46661147
178regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46020470
179cardiac muscle hypertrophy in response to stress (GO:0014898)2.44307923
180muscle hypertrophy in response to stress (GO:0003299)2.44307923
181cardiac muscle adaptation (GO:0014887)2.44307923
182sexual reproduction (GO:0019953)2.43027004
183generation of neurons (GO:0048699)2.40846193
184establishment of monopolar cell polarity (GO:0061162)2.38722382
185establishment or maintenance of monopolar cell polarity (GO:0061339)2.38722382
186auditory behavior (GO:0031223)2.38645941
187metanephric mesenchyme development (GO:0072075)2.37708072
188vocalization behavior (GO:0071625)2.37399063
189positive regulation of synapse maturation (GO:0090129)2.37387069
190cerebral cortex neuron differentiation (GO:0021895)2.37285600
191convergent extension (GO:0060026)2.35499503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.90501428
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.10471789
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.98659093
4* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.18085823
5AR_21572438_ChIP-Seq_LNCaP_Human2.97389700
6* LXR_22292898_ChIP-Seq_THP-1_Human2.51718826
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44882392
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44882392
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40740682
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.40490535
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32526074
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22768301
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.18514703
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16799897
15CTCF_27219007_Chip-Seq_Bcells_Human2.14403792
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12152974
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.11888232
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07294154
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.04454904
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02705386
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01291926
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.99260450
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97464074
24* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.88587731
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84938092
26SMC4_20622854_ChIP-Seq_HELA_Human1.83487142
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79955196
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78663550
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.77134046
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76592965
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.76331646
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75437659
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.74631987
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72347834
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72281462
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70919886
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.67529635
38EZH2_22144423_ChIP-Seq_EOC_Human1.64254169
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63857626
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.58020072
41P68_20966046_ChIP-Seq_HELA_Human1.54854744
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52152317
43KDM2B_26808549_Chip-Seq_DND41_Human1.50876737
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50627543
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.43954808
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43441868
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42365856
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.41945204
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41333006
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40888147
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40888147
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34711519
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.32828414
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.32309146
55TCF7_22412390_ChIP-Seq_EML_Mouse1.31751001
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31702261
57* REST_21632747_ChIP-Seq_MESCs_Mouse1.29051713
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.28946409
59* RUNX1_27514584_Chip-Seq_MCF-7_Human1.28763462
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28354367
61DROSHA_22980978_ChIP-Seq_HELA_Human1.27544650
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27318324
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27116768
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26357534
65* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26116565
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25333969
67TP63_22573176_ChIP-Seq_HFKS_Human1.25041361
68RACK7_27058665_Chip-Seq_MCF-7_Human1.25034512
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.24109684
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23915170
71* KDM2B_26808549_Chip-Seq_K562_Human1.23796804
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22877539
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22387461
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22035006
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21983212
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.21197511
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.20911882
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.19559208
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18809517
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.18474182
81AHR_22903824_ChIP-Seq_MCF-7_Human1.17698289
82* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16909955
83OCT4_19829295_ChIP-Seq_ESCs_Human1.16484923
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16022632
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.15675802
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.15047533
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14778516
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13690726
89CJUN_26792858_Chip-Seq_BT549_Human1.13626828
90TP53_18474530_ChIP-ChIP_U2OS_Human1.13614903
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12833960
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12773956
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12302154
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.10445743
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09137183
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07964934
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07762848
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.07526408
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07418190
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06857703
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06397288
102REST_18959480_ChIP-ChIP_MESCs_Mouse1.06342522
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.05576669
104* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05566260
105CLOCK_20551151_ChIP-Seq_293T_Human1.05533400
106* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05286606
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.04351173
108SA1_27219007_Chip-Seq_Bcells_Human1.03704585
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03523099
110GATA1_22025678_ChIP-Seq_K562_Human1.02967409
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02751897
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.02633411
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02436988
114RXR_22108803_ChIP-Seq_LS180_Human1.02266297
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01995951
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01995951
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01899886
118MYC_27129775_Chip-Seq_CORNEA_Mouse1.01174948
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01069021
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00534676
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.99575610
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99501085
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99073240
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98977250
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98024627
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97562464
127* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97447797
128BCL6_27268052_Chip-Seq_Bcells_Human0.97125619
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96880734
130CREB1_26743006_Chip-Seq_LNCaP_Human0.96606306
131* MITF_21258399_ChIP-Seq_MELANOMA_Human0.96448208
132BCOR_27268052_Chip-Seq_Bcells_Human0.94193669
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94006596
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93888220
135E2F1_20622854_ChIP-Seq_HELA_Human0.93498073
136PHF8_20622854_ChIP-Seq_HELA_Human0.93098693
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92826637
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92685269
139GBX2_23144817_ChIP-Seq_PC3_Human0.91241337
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90810833
141* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88022852
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87810469
143* VDR_24787735_ChIP-Seq_THP-1_Human0.86832336
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86752505
145HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85711328
146SOX2_20726797_ChIP-Seq_SW620_Human0.85174741
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83531572
148SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81162762
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80856105
150JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80237971
151LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80064779
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.79258650
153NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76408799
154IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76143367
155STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75990413
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.75967593
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75079320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.83078116
2MP0004134_abnormal_chest_morphology4.79459014
3MP0005503_abnormal_tendon_morphology4.25796040
4MP0003879_abnormal_hair_cell4.05737850
5MP0005377_hearing/vestibular/ear_phenot4.00385033
6MP0003878_abnormal_ear_physiology4.00385033
7MP0002933_joint_inflammation3.74884022
8MP0002282_abnormal_trachea_morphology3.47358144
9MP0001485_abnormal_pinna_reflex3.39092044
10MP0009780_abnormal_chondrocyte_physiolo3.22401081
11MP0009250_abnormal_appendicular_skeleto3.13759264
12MP0005410_abnormal_fertilization3.13613569
13* MP0000163_abnormal_cartilage_morphology2.94028277
14MP0008438_abnormal_cutaneous_collagen2.91738508
15MP0002822_catalepsy2.91702583
16MP0005508_abnormal_skeleton_morphology2.79778000
17* MP0001963_abnormal_hearing_physiology2.70146113
18* MP0002115_abnormal_skeleton_extremities2.63834750
19MP0001299_abnormal_eye_distance/2.55226410
20MP0000566_synostosis2.47243291
21MP0002089_abnormal_postnatal_growth/wei2.36016277
22* MP0000026_abnormal_inner_ear2.35969625
23MP0000762_abnormal_tongue_morphology2.33037195
24MP0004381_abnormal_hair_follicle2.26589095
25MP0002896_abnormal_bone_mineralization2.25608153
26MP0001348_abnormal_lacrimal_gland2.10162619
27MP0000049_abnormal_middle_ear2.07995974
28MP0005390_skeleton_phenotype2.07107893
29MP0004510_myositis2.03271003
30MP0003283_abnormal_digestive_organ2.01303372
31* MP0002113_abnormal_skeleton_development1.98126036
32MP0004270_analgesia1.94095541
33MP0005408_hypopigmentation1.93789373
34MP0005423_abnormal_somatic_nervous1.93195129
35MP0005275_abnormal_skin_tensile1.92488446
36MP0005670_abnormal_white_adipose1.90529940
37MP0002109_abnormal_limb_morphology1.89164982
38MP0002249_abnormal_larynx_morphology1.86856030
39MP0004272_abnormal_basement_membrane1.86771222
40MP0009384_cardiac_valve_regurgitation1.86084955
41MP0002932_abnormal_joint_morphology1.83887982
42MP0004036_abnormal_muscle_relaxation1.73895334
43MP0001542_abnormal_bone_strength1.71114377
44MP0004084_abnormal_cardiac_muscle1.69421139
45MP0001270_distended_abdomen1.69180118
46MP0001533_abnormal_skeleton_physiology1.69171465
47MP0004885_abnormal_endolymph1.61167981
48MP0000751_myopathy1.58484869
49MP0008569_lethality_at_weaning1.58474448
50MP0003646_muscle_fatigue1.57421071
51* MP0002116_abnormal_craniofacial_bone1.53411306
52MP0003635_abnormal_synaptic_transmissio1.52293824
53MP0002108_abnormal_muscle_morphology1.51893312
54MP0010030_abnormal_orbit_morphology1.49033692
55MP0003136_yellow_coat_color1.48300076
56MP0003755_abnormal_palate_morphology1.44624299
57MP0005248_abnormal_Harderian_gland1.43830516
58MP0002233_abnormal_nose_morphology1.42615129
59MP0003942_abnormal_urinary_system1.37859650
60MP0003698_abnormal_male_reproductive1.35802327
61MP0003795_abnormal_bone_structure1.34783700
62MP0000569_abnormal_digit_pigmentation1.30938087
63MP0002111_abnormal_tail_morphology1.26702656
64MP0000955_abnormal_spinal_cord1.26531986
65MP0000428_abnormal_craniofacial_morphol1.26373955
66MP0003705_abnormal_hypodermis_morpholog1.25263643
67MP0002063_abnormal_learning/memory/cond1.25134083
68MP0000534_abnormal_ureter_morphology1.25076539
69MP0003941_abnormal_skin_development1.24739498
70MP0002998_abnormal_bone_remodeling1.21689438
71MP0000749_muscle_degeneration1.21022847
72MP0002938_white_spotting1.19206320
73MP0003123_paternal_imprinting1.18073873
74MP0005623_abnormal_meninges_morphology1.16383175
75MP0003634_abnormal_glial_cell1.16306350
76MP0003122_maternal_imprinting1.15965419
77MP0000678_abnormal_parathyroid_gland1.14287198
78MP0004858_abnormal_nervous_system1.14242914
79MP0001958_emphysema1.14049465
80MP0003172_abnormal_lysosome_physiology1.13780425
81MP0002572_abnormal_emotion/affect_behav1.10978018
82MP0003329_amyloid_beta_deposits1.10910577
83MP0000462_abnormal_digestive_system1.10387637
84MP0003279_aneurysm1.08777475
85MP0002734_abnormal_mechanical_nocicepti1.08525238
86MP0003937_abnormal_limbs/digits/tail_de1.07880324
87MP0004087_abnormal_muscle_fiber1.07227800
88MP0003935_abnormal_craniofacial_develop1.02549571
89MP0002114_abnormal_axial_skeleton1.02416774
90* MP0000432_abnormal_head_morphology1.02374843
91MP0002064_seizures1.01895165
92MP0000759_abnormal_skeletal_muscle1.00792269
93MP0000383_abnormal_hair_follicle0.97769343
94MP0000372_irregular_coat_pigmentation0.96616524
95MP0002272_abnormal_nervous_system0.96024559
96MP0010678_abnormal_skin_adnexa0.95981537
97MP0003137_abnormal_impulse_conducting0.94256724
98MP0001346_abnormal_lacrimal_gland0.93181433
99MP0003880_abnormal_central_pattern0.93124679
100MP0005620_abnormal_muscle_contractility0.91757988
101MP0002882_abnormal_neuron_morphology0.90732851
102MP0005409_darkened_coat_color0.89940748
103MP0002067_abnormal_sensory_capabilities0.88893935
104MP0010630_abnormal_cardiac_muscle0.88070808
105MP0002735_abnormal_chemical_nociception0.87098652
106MP0001486_abnormal_startle_reflex0.86935504
107MP0003861_abnormal_nervous_system0.86793408
108MP0003938_abnormal_ear_development0.86699793
109MP0000747_muscle_weakness0.85963776
110MP0004185_abnormal_adipocyte_glucose0.85799200
111MP0001286_abnormal_eye_development0.84530634
112MP0002075_abnormal_coat/hair_pigmentati0.83589474
113MP0002653_abnormal_ependyma_morphology0.83501712
114MP0001929_abnormal_gametogenesis0.83178559
115MP0005369_muscle_phenotype0.83067741
116MP0006138_congestive_heart_failure0.82194153
117MP0004811_abnormal_neuron_physiology0.80973726
118MP0003119_abnormal_digestive_system0.80680282
119MP0005075_abnormal_melanosome_morpholog0.80494332
120MP0001849_ear_inflammation0.78511109
121MP0002106_abnormal_muscle_physiology0.78201591
122MP0002234_abnormal_pharynx_morphology0.77865691
123MP0003385_abnormal_body_wall0.77741033
124MP0002161_abnormal_fertility/fecundity0.75530541
125MP0002909_abnormal_adrenal_gland0.75176335
126MP0005023_abnormal_wound_healing0.74934387
127MP0001502_abnormal_circadian_rhythm0.74824166
128MP0002557_abnormal_social/conspecific_i0.74657085
129MP0003632_abnormal_nervous_system0.74061893
130MP0004264_abnormal_extraembryonic_tissu0.73011652
131MP0003115_abnormal_respiratory_system0.72127624
132MP0004742_abnormal_vestibular_system0.70469436
133MP0006054_spinal_hemorrhage0.68745271
134MP0000733_abnormal_muscle_development0.68419277
135MP0004197_abnormal_fetal_growth/weight/0.67549144
136MP0000579_abnormal_nail_morphology0.67068240
137MP0001943_abnormal_respiration0.66177814
138MP0001340_abnormal_eyelid_morphology0.65264802
139MP0009053_abnormal_anal_canal0.61434848
140MP0002752_abnormal_somatic_nervous0.56125129
141MP0002060_abnormal_skin_morphology0.55271264
142MP0000920_abnormal_myelination0.54220888
143MP0005164_abnormal_response_to0.53822746
144MP0002184_abnormal_innervation0.53807590
145MP0000537_abnormal_urethra_morphology0.53768923
146MP0004859_abnormal_synaptic_plasticity0.52861296
147MP0005076_abnormal_cell_differentiation0.51051894
148MP0002295_abnormal_pulmonary_circulatio0.50489184
149MP0003787_abnormal_imprinting0.49429068
150MP0005257_abnormal_intraocular_pressure0.48382610
151MP0005381_digestive/alimentary_phenotyp0.47449033
152MP0000631_abnormal_neuroendocrine_gland0.46909716
153MP0003566_abnormal_cell_adhesion0.46677678
154MP0000778_abnormal_nervous_system0.46637347
155MP0003091_abnormal_cell_migration0.45733698
156MP0000767_abnormal_smooth_muscle0.44512249

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)8.98038547
2Vitreoretinal degeneration (HP:0000655)7.70005754
3Small epiphyses (HP:0010585)7.30906347
4Peripheral hypomyelination (HP:0007182)5.71328696
5Mild short stature (HP:0003502)5.61567481
6Delayed epiphyseal ossification (HP:0002663)5.44470404
7Genu varum (HP:0002970)5.38320318
8* Hypoplastic ischia (HP:0003175)5.27945059
9Cupped ribs (HP:0000887)5.02160903
10* Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.79808349
11Flattened epiphyses (HP:0003071)4.72863249
12Flat capital femoral epiphysis (HP:0003370)4.59159266
13Neonatal short-limb short stature (HP:0008921)4.59058904
14* Abnormality of the ischium (HP:0003174)4.56083248
15Abnormal tarsal ossification (HP:0008369)4.24206339
16* Osteoarthritis (HP:0002758)4.23603936
17Metaphyseal cupping (HP:0003021)4.19346886
18Abnormal vertebral ossification (HP:0100569)4.14450942
19Flat acetabular roof (HP:0003180)4.11644013
20Abnormality of the vertebral endplates (HP:0005106)3.95282413
21White forelock (HP:0002211)3.75419818
22Hypoplasia of the iris (HP:0007676)3.49020853
23* Platyspondyly (HP:0000926)3.44020432
24Fetal akinesia sequence (HP:0001989)3.43376166
25Severe Myopia (HP:0011003)3.32019120
26Short femoral neck (HP:0100864)3.29256003
27Morphological abnormality of the inner ear (HP:0011390)3.26460225
28Irregular vertebral endplates (HP:0003301)3.14461092
29Calcaneovalgus deformity (HP:0001848)3.09719802
30Abnormal foot bone ossification (HP:0010675)3.08889293
31Patchy hypopigmentation of hair (HP:0011365)3.07669540
32* Abnormality of femoral epiphyses (HP:0006499)3.05924686
33* Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.05924686
34Limited hip movement (HP:0008800)3.04281920
35Round ear (HP:0100830)3.02603543
36Barrel-shaped chest (HP:0001552)3.02198328
37Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.01984151
38Abnormality of the vitreous humor (HP:0004327)3.01782319
39Distal arthrogryposis (HP:0005684)2.99513250
40Asymmetric septal hypertrophy (HP:0001670)2.99479004
41* Mixed hearing impairment (HP:0000410)2.98326532
42Arthropathy (HP:0003040)2.97775223
43Abnormality of the calcaneus (HP:0008364)2.97327259
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.97098005
45Akinesia (HP:0002304)2.92242842
46Metaphyseal dysplasia (HP:0100255)2.90969128
47Action tremor (HP:0002345)2.88579042
48Cervical subluxation (HP:0003308)2.85697822
49Obstructive sleep apnea (HP:0002870)2.81946773
50Ulnar deviation of the wrist (HP:0003049)2.81568665
51Coxa vara (HP:0002812)2.81062104
52Abnormality of the aortic arch (HP:0012303)2.79733997
53Hip contracture (HP:0003273)2.76558418
54Metaphyseal irregularity (HP:0003025)2.74255121
55* Abnormality of the pubic bones (HP:0003172)2.74185800
56Limited elbow extension (HP:0001377)2.71607714
57Waddling gait (HP:0002515)2.71437490
58Abnormal auditory evoked potentials (HP:0006958)2.68559738
59* Abnormality of the epiphysis of the femoral head (HP:0010574)2.67006276
60Alacrima (HP:0000522)2.64547404
61Mesomelia (HP:0003027)2.60390112
62Termporal pattern (HP:0011008)2.59817227
63Insidious onset (HP:0003587)2.59817227
64Deformed tarsal bones (HP:0008119)2.59622089
65Neoplasm of the heart (HP:0100544)2.58139315
66Aplasia/hypoplasia of the femur (HP:0005613)2.57293430
67Abnormality of carpal bone ossification (HP:0006257)2.55063185
68Heterochromia iridis (HP:0001100)2.54276361
69Abnormality of the proximal phalanges of the hand (HP:0009834)2.51398717
70Hypoplastic pelvis (HP:0008839)2.49918786
71Blue irides (HP:0000635)2.47138085
72Abnormality of the middle phalanges of the toes (HP:0010183)2.46499367
73* Abnormality of the femoral head (HP:0003368)2.45669852
74Aplasia of the musculature (HP:0100854)2.39486459
75Thoracolumbar scoliosis (HP:0002944)2.38905832
76Premature rupture of membranes (HP:0001788)2.36357191
77* Micromelia (HP:0002983)2.35833514
78* Absent epiphyses (HP:0010577)2.35347716
79* Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.35347716
80Spinal cord compression (HP:0002176)2.34797909
81Radial bowing (HP:0002986)2.31969460
82Abnormality of incisor morphology (HP:0011063)2.31639756
83Cerebral aneurysm (HP:0004944)2.31394581
84Abnormality of the 2nd finger (HP:0004100)2.29317254
85Hypoplasia of the odontoid process (HP:0003311)2.28612827
86* Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.26770109
87Hypopigmentation of the fundus (HP:0007894)2.26729444
88Ulnar bowing (HP:0003031)2.25953453
89Beaking of vertebral bodies (HP:0004568)2.25951388
90Protrusio acetabuli (HP:0003179)2.24548354
91Abnormality of the intervertebral disk (HP:0005108)2.24297942
92Cerebral hypomyelination (HP:0006808)2.23479259
93Popliteal pterygium (HP:0009756)2.21883204
94Relative macrocephaly (HP:0004482)2.21271524
95Congenital malformation of the right heart (HP:0011723)2.19450241
96Double outlet right ventricle (HP:0001719)2.19450241
97Carpal bone hypoplasia (HP:0001498)2.19175418
98Ulnar claw (HP:0001178)2.18842137
99Thin ribs (HP:0000883)2.18382137
100Upper limb amyotrophy (HP:0009129)2.18297068
101Distal upper limb amyotrophy (HP:0007149)2.18297068
102Malignant hyperthermia (HP:0002047)2.17779816
103Lymphangioma (HP:0100764)2.17021541
104Tracheomalacia (HP:0002779)2.15134758
105Underdeveloped nasal alae (HP:0000430)2.12456349
106Absent frontal sinuses (HP:0002688)2.12032219
107* Protuberant abdomen (HP:0001538)2.11964636
108Ovoid vertebral bodies (HP:0003300)2.11840104
109Abnormal hand bone ossification (HP:0010660)2.11068004
110Truncus arteriosus (HP:0001660)2.10829583
111Short middle phalanx of finger (HP:0005819)2.08359447
112Turricephaly (HP:0000262)2.04426973
113* Exostoses (HP:0100777)2.04387339
114Shallow orbits (HP:0000586)2.03797730
115Hypoplastic heart (HP:0001961)2.03765763
116Abnormality of the lumbar spine (HP:0100712)2.03229707
117Genu valgum (HP:0002857)2.02976236
118Synostosis involving the elbow (HP:0003938)2.02543582
119Humeroradial synostosis (HP:0003041)2.02543582
120Abnormal ossification of hand bones (HP:0005921)2.02040132
121* Vertebral clefting (HP:0008428)2.00511837
122Abnormality of the left ventricular outflow tract (HP:0011103)2.00456159
123Subaortic stenosis (HP:0001682)2.00456159
124* Lumbar hyperlordosis (HP:0002938)2.00093320
125* Epiphyseal dysplasia (HP:0002656)10.4592813
126Broad long bones (HP:0005622)1.98225049
127Broad phalanx (HP:0006009)1.95857390
128Abnormality of dentin (HP:0010299)1.94969632
129Long clavicles (HP:0000890)1.94738977
130Severe visual impairment (HP:0001141)1.93601854
131Broad thumb (HP:0011304)1.93053152
132Fibular hypoplasia (HP:0003038)1.92966346
133Stillbirth (HP:0003826)1.91525325
134* Rhizomelia (HP:0008905)1.90417306
135Spastic paraparesis (HP:0002313)1.89864548
136Atrophic scars (HP:0001075)1.89440020
137Disproportionate short-trunk short stature (HP:0003521)1.89180513
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.89155782
139Abnormality of the odontoid process (HP:0003310)1.88188513
140Broad ribs (HP:0000885)1.85322273
141Myokymia (HP:0002411)1.85113131
142Type 1 muscle fiber predominance (HP:0003803)1.83327550
143Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82092234
144Vertebral hypoplasia (HP:0008417)1.82092234
145Chin dimple (HP:0010751)1.80439987
146Atelectasis (HP:0100750)1.79655358
147Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79177757
148Hyperacusis (HP:0010780)1.78932430
149Segmental peripheral demyelination/remyelination (HP:0003481)1.78767679
150Bowing of the arm (HP:0006488)1.78046328
151Bowed forearm bones (HP:0003956)1.78046328
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.77827013
153Decreased lacrimation (HP:0000633)1.77683100
154Ocular albinism (HP:0001107)1.76798569
155Arterial tortuosity (HP:0005116)1.76621202
156Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.75993641
157Muscle fiber splitting (HP:0003555)1.75650655
158Ventricular tachycardia (HP:0004756)1.74777930
159* Bell-shaped thorax (HP:0001591)1.74777392
160Neurofibrillary tangles (HP:0002185)1.74691542
161Sudden death (HP:0001699)1.72920637
162Upper limb muscle weakness (HP:0003484)1.72831899
163Ectopia lentis (HP:0001083)1.72376313
164Hammertoe (HP:0001765)1.70492022
165Disproportionate tall stature (HP:0001519)1.69245019
166Abnormality of the 4th metacarpal (HP:0010012)1.68593055
167Progressive sensorineural hearing impairment (HP:0000408)1.67433772
168Nasal speech (HP:0001611)1.67247794
169Lower limb amyotrophy (HP:0007210)1.66429904
170Hand muscle atrophy (HP:0009130)1.63993919
171Renovascular hypertension (HP:0100817)1.63619300
172Preauricular pit (HP:0004467)1.63316989
173Periauricular skin pits (HP:0100277)1.63316989
174Fragile skin (HP:0001030)1.61838787
175Broad palm (HP:0001169)1.61705895
176Distal lower limb amyotrophy (HP:0008944)1.61275427
177Annular pancreas (HP:0001734)1.60190449
178Mask-like facies (HP:0000298)1.59246110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.80638476
2LATS13.48809022
3MAP3K33.26141273
4* DDR23.09429421
5TRIB33.00046063
6EPHB12.93093423
7TRPM72.80683840
8TESK12.79922109
9STK392.69973585
10MAPK152.59909713
11PLK42.59836363
12CDK122.41413226
13EEF2K2.40083690
14STK38L2.15029664
15MARK12.09604930
16WNK42.03809207
17NME11.99083931
18NTRK21.86417832
19PRKG21.84756373
20NTRK11.84650455
21STK381.84636061
22STK241.78550962
23BRD41.71563949
24FGFR11.68001686
25PRKD31.65118804
26FGFR21.63988102
27PKN21.62163542
28STK31.60976384
29PNCK1.57604091
30MET1.56586283
31ERBB31.54413177
32PDGFRA1.54287092
33SIK21.54096636
34CSNK1A1L1.53319172
35MST1R1.51451046
36UHMK11.51047374
37WNK11.42708328
38EPHA31.39124138
39FGFR31.28806700
40PLK21.26431839
41TAOK11.26001335
42RIPK11.22193138
43DYRK1B1.21989051
44MTOR1.13319092
45MARK31.13015358
46ICK1.07066274
47FGFR41.06820259
48PAK31.06157568
49OXSR11.05342588
50EPHA41.05229686
51MST41.04444709
52BMX1.04175171
53NUAK11.02787457
54CAMK1G1.01025910
55INSRR1.00709112
56ROCK20.99824966
57PAK60.99350662
58PDGFRB0.99032995
59EPHB20.97453983
60TYRO30.93302440
61NEK60.92287691
62CSNK1G10.91946846
63MAP3K90.91237481
64LMTK20.90459217
65PHKG20.87162260
66PHKG10.87162260
67PRKCH0.86632851
68ROCK10.86301155
69CAMK40.86233792
70PTK60.85734078
71RPS6KA20.85625037
72PRPF4B0.85532219
73DYRK1A0.85291925
74PDK10.81456397
75SMG10.76823783
76GSK3A0.76515576
77MAPK70.75012569
78KSR10.73856323
79MKNK20.72784220
80ERBB20.72530848
81RET0.72385461
82CAMK10.69108483
83DAPK20.68814640
84MAP3K70.67836731
85CDK190.67587510
86CDK11A0.66604888
87LATS20.65951157
88CDC42BPA0.65010323
89CDK60.64999188
90CSNK1G30.64803128
91PBK0.64774338
92RPS6KA60.62408306
93CDK50.62240287
94PAK20.62215473
95SGK4940.61614943
96SGK2230.61614943
97TNIK0.61461782
98CDK70.60838728
99MAP3K130.58768975
100PIM20.57553792
101MARK20.57527594
102DMPK0.56778229
103CSNK1G20.56560909
104MAP2K20.56214529
105TNK20.55637307
106MKNK10.55332665
107OBSCN0.54224402
108GSK3B0.53901104
109LRRK20.53811934
110RPS6KL10.51788630
111RPS6KC10.51788630
112PRKD20.51087092
113MAPK80.50310373
114PRKCE0.50303640
115MAPK120.50068641
116PAK40.48910819
117CSF1R0.48864344
118SGK10.48834200
119PRKD10.48714751
120HIPK20.48606125
121MAP3K110.47968050
122PTK2B0.47955189
123CDK150.45528577
124CAMK1D0.45120287
125ABL10.43813315
126FYN0.43787855
127MINK10.43660488
128BRAF0.43639979
129MAPK10.42373343
130CDK20.42120120
131PTK20.41939454
132PRKG10.41462275
133MAPK100.41181371
134FER0.40433880
135CDK180.38766995
136KSR20.38282486
137MAPKAPK50.38226609
138PIK3CA0.36600047
139ILK0.36341965
140NTRK30.36323761
141CAMKK10.36207305
142PKN10.36188915
143SRC0.36145035
144LIMK10.36048103
145MAPK140.35793482
146PRKCQ0.35278972
147YES10.35135021
148PDPK10.34865227
149PRKCZ0.34576862
150MAP3K100.33636910

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.50640373
2* Protein digestion and absorption_Homo sapiens_hsa049744.61280409
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.53773451
4Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.24259968
5Basal cell carcinoma_Homo sapiens_hsa052172.49662733
6Focal adhesion_Homo sapiens_hsa045102.49562716
7Hippo signaling pathway_Homo sapiens_hsa043902.16250574
8TGF-beta signaling pathway_Homo sapiens_hsa043502.05049610
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.75608958
10PI3K-Akt signaling pathway_Homo sapiens_hsa041511.64068487
11Hedgehog signaling pathway_Homo sapiens_hsa043401.59381225
12Notch signaling pathway_Homo sapiens_hsa043301.55275502
13Proteoglycans in cancer_Homo sapiens_hsa052051.54099078
14Wnt signaling pathway_Homo sapiens_hsa043101.53309303
15Dorso-ventral axis formation_Homo sapiens_hsa043201.47828754
16Long-term potentiation_Homo sapiens_hsa047201.43412344
17Melanogenesis_Homo sapiens_hsa049161.42680324
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40966961
19Axon guidance_Homo sapiens_hsa043601.38979305
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36559739
21Synaptic vesicle cycle_Homo sapiens_hsa047211.33506749
22Malaria_Homo sapiens_hsa051441.31224220
23VEGF signaling pathway_Homo sapiens_hsa043701.25741440
24Calcium signaling pathway_Homo sapiens_hsa040201.25216022
25Taste transduction_Homo sapiens_hsa047421.25086675
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20826748
27Lysine degradation_Homo sapiens_hsa003101.18666072
28Morphine addiction_Homo sapiens_hsa050321.18569007
29Sphingolipid metabolism_Homo sapiens_hsa006001.15719429
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15384127
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15352067
32Sulfur metabolism_Homo sapiens_hsa009201.15115440
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14480839
34Nicotine addiction_Homo sapiens_hsa050331.12935923
35Steroid biosynthesis_Homo sapiens_hsa001001.10199589
36Type II diabetes mellitus_Homo sapiens_hsa049301.10177778
37Olfactory transduction_Homo sapiens_hsa047401.09880052
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09323669
39Long-term depression_Homo sapiens_hsa047301.08475251
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08153276
41Cardiac muscle contraction_Homo sapiens_hsa042601.05255165
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00553736
43Inositol phosphate metabolism_Homo sapiens_hsa005621.00142517
44Cocaine addiction_Homo sapiens_hsa050300.99440663
45Dilated cardiomyopathy_Homo sapiens_hsa054140.96784362
46Endometrial cancer_Homo sapiens_hsa052130.96456963
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92408929
48Prion diseases_Homo sapiens_hsa050200.91178589
49Renal cell carcinoma_Homo sapiens_hsa052110.90612230
50Non-small cell lung cancer_Homo sapiens_hsa052230.87795550
51Insulin signaling pathway_Homo sapiens_hsa049100.87161601
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85764262
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84887696
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84811846
55Bile secretion_Homo sapiens_hsa049760.84758995
56Thyroid hormone synthesis_Homo sapiens_hsa049180.84482593
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82975829
58ErbB signaling pathway_Homo sapiens_hsa040120.82182979
59Ovarian steroidogenesis_Homo sapiens_hsa049130.80389638
60Bladder cancer_Homo sapiens_hsa052190.79183767
61Adherens junction_Homo sapiens_hsa045200.75725311
62mRNA surveillance pathway_Homo sapiens_hsa030150.74606222
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74155578
64Tight junction_Homo sapiens_hsa045300.73982541
65Prostate cancer_Homo sapiens_hsa052150.73856910
66Estrogen signaling pathway_Homo sapiens_hsa049150.73684458
67Gap junction_Homo sapiens_hsa045400.73633294
68Chronic myeloid leukemia_Homo sapiens_hsa052200.72993554
69Prolactin signaling pathway_Homo sapiens_hsa049170.71060904
70Salivary secretion_Homo sapiens_hsa049700.70686995
71Small cell lung cancer_Homo sapiens_hsa052220.70152623
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.69873047
73Oocyte meiosis_Homo sapiens_hsa041140.69635347
74Glioma_Homo sapiens_hsa052140.69540769
75AMPK signaling pathway_Homo sapiens_hsa041520.69459398
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69096065
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67950140
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.67903544
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67288416
80MicroRNAs in cancer_Homo sapiens_hsa052060.66599013
81Glucagon signaling pathway_Homo sapiens_hsa049220.66562481
82Circadian entrainment_Homo sapiens_hsa047130.66187064
83Amoebiasis_Homo sapiens_hsa051460.65920226
84Thyroid cancer_Homo sapiens_hsa052160.65617078
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65117603
86Cholinergic synapse_Homo sapiens_hsa047250.64437335
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64337104
88Acute myeloid leukemia_Homo sapiens_hsa052210.62959678
89Amphetamine addiction_Homo sapiens_hsa050310.62593702
90Fatty acid biosynthesis_Homo sapiens_hsa000610.61691899
91Gastric acid secretion_Homo sapiens_hsa049710.59935767
92Pathways in cancer_Homo sapiens_hsa052000.59876422
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59771820
94Rap1 signaling pathway_Homo sapiens_hsa040150.58297997
95Colorectal cancer_Homo sapiens_hsa052100.57951981
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56697508
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.54633900
98Melanoma_Homo sapiens_hsa052180.53872823
99Other glycan degradation_Homo sapiens_hsa005110.53672912
100Insulin resistance_Homo sapiens_hsa049310.52943969
101Ras signaling pathway_Homo sapiens_hsa040140.51718426
102Vibrio cholerae infection_Homo sapiens_hsa051100.51576366
103Ether lipid metabolism_Homo sapiens_hsa005650.51239071
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50264534
105Dopaminergic synapse_Homo sapiens_hsa047280.49306702
106GnRH signaling pathway_Homo sapiens_hsa049120.49283072
107Oxytocin signaling pathway_Homo sapiens_hsa049210.49067172
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48721182
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47904439
110Renin secretion_Homo sapiens_hsa049240.47833818
111Choline metabolism in cancer_Homo sapiens_hsa052310.47370371
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47358794
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.46931926
114Insulin secretion_Homo sapiens_hsa049110.46765794
115Arginine and proline metabolism_Homo sapiens_hsa003300.46280798
116Glutamatergic synapse_Homo sapiens_hsa047240.46007140
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.45251129
118MAPK signaling pathway_Homo sapiens_hsa040100.44899882
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43944316
120cAMP signaling pathway_Homo sapiens_hsa040240.42977144
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42514491
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41118983
123Starch and sucrose metabolism_Homo sapiens_hsa005000.41088198
124Platelet activation_Homo sapiens_hsa046110.40272842
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.37964934
126Pancreatic cancer_Homo sapiens_hsa052120.36737626
127TNF signaling pathway_Homo sapiens_hsa046680.35724020
128GABAergic synapse_Homo sapiens_hsa047270.35477067
129Endocytosis_Homo sapiens_hsa041440.35002549
130mTOR signaling pathway_Homo sapiens_hsa041500.34696731
131Phagosome_Homo sapiens_hsa041450.34566099
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.32755271
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.31448691

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