COG7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.63805898
2daunorubicin metabolic process (GO:0044597)6.63805898
3polyketide metabolic process (GO:0030638)6.63805898
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.41923512
5axonemal dynein complex assembly (GO:0070286)6.09624635
6epithelial cilium movement (GO:0003351)5.76706060
7cilium movement (GO:0003341)5.17723749
8response to pheromone (GO:0019236)4.73837383
9aminoglycoside antibiotic metabolic process (GO:0030647)4.63349790
10membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.44083338
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.39119622
12NADH dehydrogenase complex assembly (GO:0010257)4.39119622
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.39119622
14protein complex biogenesis (GO:0070271)4.28882182
15membrane repolarization during action potential (GO:0086011)4.05518666
16mitochondrial respiratory chain complex assembly (GO:0033108)3.96402054
17cilium or flagellum-dependent cell motility (GO:0001539)3.93289472
18detection of calcium ion (GO:0005513)3.91027803
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.76497747
20regulation of cilium movement (GO:0003352)3.60627992
21motile cilium assembly (GO:0044458)3.60241607
22kidney morphogenesis (GO:0060993)3.42582854
23axoneme assembly (GO:0035082)3.39641929
24protein polyglutamylation (GO:0018095)3.36412143
25regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.36036881
26ATP synthesis coupled proton transport (GO:0015986)3.35103178
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35103178
28peptide hormone processing (GO:0016486)3.32153519
29cell proliferation in forebrain (GO:0021846)3.31460858
30vocalization behavior (GO:0071625)3.30272933
31insulin secretion (GO:0030073)3.29002083
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25210666
33somite development (GO:0061053)3.24967164
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.22037761
35endocrine pancreas development (GO:0031018)3.21706150
36regulation of type B pancreatic cell apoptotic process (GO:2000674)3.19703158
37cilium organization (GO:0044782)3.19540578
38retinal ganglion cell axon guidance (GO:0031290)3.19276143
39membrane repolarization (GO:0086009)3.17857053
40protein localization to cilium (GO:0061512)3.15844713
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14818250
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.12203381
43cornea development in camera-type eye (GO:0061303)3.11503775
44regulation of short-term neuronal synaptic plasticity (GO:0048172)3.08553203
45urinary tract smooth muscle contraction (GO:0014848)3.08342350
46pigment granule localization (GO:0051875)3.05553285
47DNA deamination (GO:0045006)3.04666939
48cilium assembly (GO:0042384)3.03698371
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.03165947
50limb development (GO:0060173)3.02985590
51appendage development (GO:0048736)3.02985590
52drinking behavior (GO:0042756)2.99626190
53left/right pattern formation (GO:0060972)2.98581409
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98076039
55positive regulation of potassium ion transmembrane transport (GO:1901381)2.96784084
56auditory receptor cell stereocilium organization (GO:0060088)2.95731846
57presynaptic membrane assembly (GO:0097105)2.95356339
58pigment granule transport (GO:0051904)2.93861268
59nephron epithelium morphogenesis (GO:0072088)2.92669603
60nephron tubule morphogenesis (GO:0072078)2.92669603
61nitric oxide mediated signal transduction (GO:0007263)2.91336866
62water-soluble vitamin biosynthetic process (GO:0042364)2.89504261
63Golgi transport vesicle coating (GO:0048200)2.88805660
64COPI coating of Golgi vesicle (GO:0048205)2.88805660
65regulation of synaptic vesicle exocytosis (GO:2000300)2.88121647
66negative regulation of norepinephrine secretion (GO:0010700)2.87917291
67spinal cord development (GO:0021510)2.86005648
68synaptic transmission, glutamatergic (GO:0035249)2.85492518
69prostate gland growth (GO:0060736)2.85241420
70establishment of pigment granule localization (GO:0051905)2.85023911
71cilium morphogenesis (GO:0060271)2.84615175
72regulation of synaptic vesicle transport (GO:1902803)2.84521659
73spinal cord motor neuron differentiation (GO:0021522)2.84183903
74lateral sprouting from an epithelium (GO:0060601)2.82824957
75positive regulation of mitochondrial fission (GO:0090141)2.77476344
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76925800
77regulation of non-canonical Wnt signaling pathway (GO:2000050)2.76403738
78ovulation cycle (GO:0042698)2.75544591
79regulation of glutamate receptor signaling pathway (GO:1900449)2.75344328
80negative regulation of transcription regulatory region DNA binding (GO:2000678)2.75225600
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75212782
82segment specification (GO:0007379)2.74923322
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.73728740
84response to xenobiotic stimulus (GO:0009410)2.72272037
85left/right axis specification (GO:0070986)2.71719736
86glutamate receptor signaling pathway (GO:0007215)2.71600911
87negative regulation of catecholamine secretion (GO:0033604)2.69458023
88serotonin metabolic process (GO:0042428)2.69274405
89nucleotide transmembrane transport (GO:1901679)2.68400643
90purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67996573
913-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67996573
92synaptic transmission, cholinergic (GO:0007271)2.67490233
93determination of left/right symmetry (GO:0007368)2.67015851
94otic vesicle formation (GO:0030916)2.66410319
95regulation of microtubule-based movement (GO:0060632)2.65518861
96glycoside metabolic process (GO:0016137)2.65155571
97regulation of insulin secretion (GO:0050796)2.64963665
98neurotransmitter-gated ion channel clustering (GO:0072578)2.64174143
99glandular epithelial cell differentiation (GO:0002067)2.63590368
100behavioral response to nicotine (GO:0035095)2.62173871
101dorsal/ventral pattern formation (GO:0009953)2.61988590
102head development (GO:0060322)2.61517961
103cellular anion homeostasis (GO:0030002)2.60628966
104positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60495064
105startle response (GO:0001964)2.60486650
106serotonin receptor signaling pathway (GO:0007210)2.59464557
107ubiquinone biosynthetic process (GO:0006744)2.59343650
108sperm motility (GO:0030317)2.59046151
109dendritic spine morphogenesis (GO:0060997)2.58174471
110embryonic epithelial tube formation (GO:0001838)2.57822715
111sulfation (GO:0051923)2.57309423
112chemosensory behavior (GO:0007635)2.57027058
113presynaptic membrane organization (GO:0097090)2.56381682
114synapse assembly (GO:0007416)2.55819340
115indolalkylamine metabolic process (GO:0006586)2.55245344
116phenol-containing compound catabolic process (GO:0019336)2.54779339
117calcium ion import (GO:0070509)2.54681567
118axon ensheathment in central nervous system (GO:0032291)2.53967127
119central nervous system myelination (GO:0022010)2.53967127
120phosphorelay signal transduction system (GO:0000160)2.53941741
121regulation of vesicle fusion (GO:0031338)2.53169730
122neuron-neuron synaptic transmission (GO:0007270)2.53050662
123ATP hydrolysis coupled proton transport (GO:0015991)2.52890944
124energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.52890944
125transferrin transport (GO:0033572)2.51910483
126melanosome localization (GO:0032400)2.51688927
127dorsal/ventral neural tube patterning (GO:0021904)2.51647572
128opioid receptor signaling pathway (GO:0038003)2.51222399
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.51026001
130ER overload response (GO:0006983)2.50830574
131protein localization to synapse (GO:0035418)2.50619984
132regulation of norepinephrine secretion (GO:0014061)2.50503308
133positive regulation of gastrulation (GO:2000543)2.50070742
134cell differentiation in spinal cord (GO:0021515)2.49558812
135substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.49305969
136substrate-independent telencephalic tangential migration (GO:0021826)2.49305969
137protein maturation by protein folding (GO:0022417)2.49301994
138regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.48592169
139positive regulation of synaptic transmission, GABAergic (GO:0032230)2.48263887
140postsynaptic membrane organization (GO:0001941)2.47897629
141parturition (GO:0007567)2.47520704
142peristalsis (GO:0030432)2.46696748
143determination of bilateral symmetry (GO:0009855)2.46353349
144negative regulation of astrocyte differentiation (GO:0048712)2.46045396
145ATP biosynthetic process (GO:0006754)2.46022855
146regulation of collateral sprouting (GO:0048670)2.45986640
147trivalent inorganic cation transport (GO:0072512)2.45193448
148ferric iron transport (GO:0015682)2.45193448
149inner ear receptor stereocilium organization (GO:0060122)2.44991337
150locomotory exploration behavior (GO:0035641)2.44959996
151negative regulation of telomere maintenance (GO:0032205)2.44726033
152GPI anchor metabolic process (GO:0006505)2.44487690
153pyrimidine nucleobase catabolic process (GO:0006208)2.44306122
154membrane depolarization during action potential (GO:0086010)2.43753409
155cochlea development (GO:0090102)2.43590585
156neuronal action potential (GO:0019228)2.43199915
157positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.42689612
158respiratory chain complex IV assembly (GO:0008535)2.42544548
159synaptic vesicle endocytosis (GO:0048488)2.42438501
160intraciliary transport (GO:0042073)2.41477358
161regulation of membrane repolarization (GO:0060306)2.40778730
162purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.40013029
163specification of symmetry (GO:0009799)2.39614129
164glycine transport (GO:0015816)2.39290100
165synaptic vesicle exocytosis (GO:0016079)2.39007611
166lactate metabolic process (GO:0006089)2.38778071
167primary amino compound metabolic process (GO:1901160)2.38370560
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37861986
169energy homeostasis (GO:0097009)2.37783620
170regulation of peptide hormone secretion (GO:0090276)2.37330693
171positive regulation of insulin secretion (GO:0032024)2.36890082
172gamma-aminobutyric acid transport (GO:0015812)2.36745900
173dendritic spine organization (GO:0097061)2.35137539
174regulation of peptide secretion (GO:0002791)2.34685481
175neuronal action potential propagation (GO:0019227)2.34427294
176detection of chemical stimulus (GO:0009593)2.34208124
177positive regulation of vesicle fusion (GO:0031340)2.32233941
178melanosome transport (GO:0032402)2.31332656
179gamma-aminobutyric acid signaling pathway (GO:0007214)2.30865971
180signal peptide processing (GO:0006465)2.30537062
181nonmotile primary cilium assembly (GO:0035058)2.29677290
182regulation of uterine smooth muscle contraction (GO:0070472)2.28745767
183peptide hormone secretion (GO:0030072)2.27997064
184vesicle localization (GO:0051648)2.27637089
185protein retention in ER lumen (GO:0006621)2.25406862
186establishment of melanosome localization (GO:0032401)2.25052025
187regulation of glucocorticoid secretion (GO:2000849)2.25051274
188neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.24932615
189response to auditory stimulus (GO:0010996)2.23547942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.29808664
2EZH2_22144423_ChIP-Seq_EOC_Human4.26459205
3ZNF274_21170338_ChIP-Seq_K562_Hela3.11090698
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.03036282
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90541412
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89673059
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55158806
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44574299
9REST_21632747_ChIP-Seq_MESCs_Mouse2.34749163
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22305970
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18286105
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.11384423
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10837965
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09819702
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08800789
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06430126
17IRF1_19129219_ChIP-ChIP_H3396_Human2.04665290
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00691361
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.00690337
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00487882
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99072902
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96714322
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93656104
24IGF1R_20145208_ChIP-Seq_DFB_Human1.89790595
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.84524446
26VDR_22108803_ChIP-Seq_LS180_Human1.81581318
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81222517
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80263249
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80263249
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79982558
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78744689
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74532529
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73912937
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72332481
35P300_19829295_ChIP-Seq_ESCs_Human1.72305472
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71829605
37DROSHA_22980978_ChIP-Seq_HELA_Human1.71119553
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65593643
39SMAD4_21799915_ChIP-Seq_A2780_Human1.64072007
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62651983
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61801947
42AR_21572438_ChIP-Seq_LNCaP_Human1.60660187
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.59346872
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.58208261
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.58158986
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55696994
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53978272
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.45476454
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.44659781
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43016018
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41196763
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38859186
53TAF15_26573619_Chip-Seq_HEK293_Human1.38327884
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38200498
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36752923
56P53_22387025_ChIP-Seq_ESCs_Mouse1.35308233
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34548242
58STAT3_23295773_ChIP-Seq_U87_Human1.32139344
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.31442779
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.30033902
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30015900
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.29863078
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28767762
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28647612
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28587595
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.27859481
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27632046
68MYC_18940864_ChIP-ChIP_HL60_Human1.26335490
69TCF4_23295773_ChIP-Seq_U87_Human1.26223895
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.23494372
71RNF2_27304074_Chip-Seq_NSC_Mouse1.23159765
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22870019
73AR_25329375_ChIP-Seq_VCAP_Human1.22797657
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22680439
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.22045858
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21857772
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21401051
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20700326
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.20080193
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19506291
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19448608
82RARB_27405468_Chip-Seq_BRAIN_Mouse1.16978656
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15627448
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.15500177
85BCAT_22108803_ChIP-Seq_LS180_Human1.15176890
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14635720
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14444874
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14246040
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.14237766
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.13811627
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13321016
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.11704778
93CBP_20019798_ChIP-Seq_JUKART_Human1.11326921
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11326921
95* ERA_21632823_ChIP-Seq_H3396_Human1.11272222
96P300_18555785_Chip-Seq_ESCs_Mouse1.10891038
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.10819333
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.10272657
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.09118263
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.08963238
101RUNX2_22187159_ChIP-Seq_PCA_Human1.08719614
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08675955
103NMYC_18555785_Chip-Seq_ESCs_Mouse1.08448400
104* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08252320
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07964841
106EWS_26573619_Chip-Seq_HEK293_Human1.07433625
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05540331
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05382295
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04572216
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03403058
111* TAF2_19829295_ChIP-Seq_ESCs_Human1.03370710
112ER_23166858_ChIP-Seq_MCF-7_Human1.03306239
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02613344
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02134603
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02002661
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.01922209
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.00885069
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00057242
119ZFX_18555785_Chip-Seq_ESCs_Mouse1.00045008
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99225896
121ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98983746
122FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98805576
123* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98583850
124* FOXA1_25329375_ChIP-Seq_VCAP_Human0.98583850
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98430814
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98321817
127OCT4_18555785_Chip-Seq_ESCs_Mouse0.98132389
128FUS_26573619_Chip-Seq_HEK293_Human0.97910355
129MYC_19829295_ChIP-Seq_ESCs_Human0.97614779
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96236791
131* KDM2B_26808549_Chip-Seq_REH_Human0.95939535
132AR_19668381_ChIP-Seq_PC3_Human0.95336629
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94867278
134TP53_22573176_ChIP-Seq_HFKS_Human0.94356579
135NCOR_22424771_ChIP-Seq_293T_Human0.94268218
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92925743
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92566509
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92566509
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91612324
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90329152
141E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89808240
142CTCF_27219007_Chip-Seq_Bcells_Human0.89546177
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86291909
144CTCF_20526341_ChIP-Seq_ESCs_Human0.86174906
145CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86160916
146NANOG_20526341_ChIP-Seq_ESCs_Human0.84048806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.07570812
2MP0003646_muscle_fatigue3.43000994
3MP0005645_abnormal_hypothalamus_physiol3.41154668
4MP0001986_abnormal_taste_sensitivity3.10198685
5MP0002653_abnormal_ependyma_morphology3.08615283
6MP0005646_abnormal_pituitary_gland2.97344126
7MP0004043_abnormal_pH_regulation2.88964490
8MP0006292_abnormal_olfactory_placode2.66599411
9MP0002638_abnormal_pupillary_reflex2.61686985
10MP0005379_endocrine/exocrine_gland_phen2.61594544
11MP0004859_abnormal_synaptic_plasticity2.54611184
12MP0002102_abnormal_ear_morphology2.38927142
13MP0000678_abnormal_parathyroid_gland2.29332029
14MP0009780_abnormal_chondrocyte_physiolo2.28354479
15MP0003283_abnormal_digestive_organ2.25622537
16MP0003195_calcinosis2.17998359
17MP0002693_abnormal_pancreas_physiology2.17647567
18MP0001501_abnormal_sleep_pattern2.08012496
19MP0002837_dystrophic_cardiac_calcinosis2.07941843
20MP0003183_abnormal_peptide_metabolism2.04229409
21MP0002735_abnormal_chemical_nociception1.94899587
22MP0000049_abnormal_middle_ear1.94608283
23MP0009745_abnormal_behavioral_response1.93298653
24MP0003635_abnormal_synaptic_transmissio1.89812331
25MP0002736_abnormal_nociception_after1.81821948
26MP0001486_abnormal_startle_reflex1.80326779
27MP0002272_abnormal_nervous_system1.79405126
28MP0002572_abnormal_emotion/affect_behav1.78015039
29MP0000013_abnormal_adipose_tissue1.77850715
30MP0003880_abnormal_central_pattern1.77317499
31MP0002160_abnormal_reproductive_system1.76834878
32MP0002876_abnormal_thyroid_physiology1.75592927
33MP0002909_abnormal_adrenal_gland1.74665785
34MP0001188_hyperpigmentation1.72795935
35MP0008789_abnormal_olfactory_epithelium1.71516693
36MP0003879_abnormal_hair_cell1.71248415
37MP0001968_abnormal_touch/_nociception1.70834005
38MP0009379_abnormal_foot_pigmentation1.69213031
39MP0008004_abnormal_stomach_pH1.66837977
40MP0002163_abnormal_gland_morphology1.66761873
41MP0001944_abnormal_pancreas_morphology1.63280811
42MP0001984_abnormal_olfaction1.62845183
43MP0000566_synostosis1.61998549
44MP0003011_delayed_dark_adaptation1.61878287
45MP0002064_seizures1.61731451
46MP0002063_abnormal_learning/memory/cond1.60873062
47MP0001664_abnormal_digestion1.54416702
48MP0006276_abnormal_autonomic_nervous1.54380982
49MP0002734_abnormal_mechanical_nocicepti1.54304805
50MP0005670_abnormal_white_adipose1.52145497
51MP0005257_abnormal_intraocular_pressure1.51643785
52MP0005423_abnormal_somatic_nervous1.49548219
53MP0003172_abnormal_lysosome_physiology1.48312480
54MP0008875_abnormal_xenobiotic_pharmacok1.44361823
55MP0002282_abnormal_trachea_morphology1.44006956
56MP0009046_muscle_twitch1.42383491
57MP0002249_abnormal_larynx_morphology1.42209481
58MP0002938_white_spotting1.40937658
59MP0002557_abnormal_social/conspecific_i1.40867282
60MP0002877_abnormal_melanocyte_morpholog1.38099595
61MP0003937_abnormal_limbs/digits/tail_de1.37173740
62MP0004270_analgesia1.37094271
63MP0001765_abnormal_ion_homeostasis1.37062913
64MP0001502_abnormal_circadian_rhythm1.35636546
65MP0003938_abnormal_ear_development1.35578466
66MP0005171_absent_coat_pigmentation1.34457430
67MP0005394_taste/olfaction_phenotype1.33903466
68MP0005499_abnormal_olfactory_system1.33903466
69MP0001529_abnormal_vocalization1.32580733
70MP0000778_abnormal_nervous_system1.31092784
71MP0001970_abnormal_pain_threshold1.30159156
72MP0002078_abnormal_glucose_homeostasis1.28941273
73MP0000372_irregular_coat_pigmentation1.28610283
74MP0000538_abnormal_urinary_bladder1.26187608
75MP0001440_abnormal_grooming_behavior1.24698313
76MP0005310_abnormal_salivary_gland1.24445063
77MP0001905_abnormal_dopamine_level1.22600977
78MP0002733_abnormal_thermal_nociception1.22275799
79MP0002067_abnormal_sensory_capabilities1.20655963
80MP0008872_abnormal_physiological_respon1.20014789
81MP0002277_abnormal_respiratory_mucosa1.18969465
82MP0003121_genomic_imprinting1.18669804
83MP0002822_catalepsy1.16794634
84MP0005389_reproductive_system_phenotype1.15754436
85MP0003942_abnormal_urinary_system1.15422889
86MP0004742_abnormal_vestibular_system1.14801172
87MP0001485_abnormal_pinna_reflex1.12411945
88MP0004145_abnormal_muscle_electrophysio1.12348308
89MP0006072_abnormal_retinal_apoptosis1.09780536
90MP0003136_yellow_coat_color1.08300273
91MP0004133_heterotaxia1.08008567
92MP0005195_abnormal_posterior_eye1.06865314
93MP0005535_abnormal_body_temperature1.05272929
94MP0002752_abnormal_somatic_nervous1.04187513
95MP0001293_anophthalmia1.04095246
96MP0004858_abnormal_nervous_system1.04046548
97MP0000681_abnormal_thyroid_gland1.03877103
98MP0008995_early_reproductive_senescence1.03401978
99MP0004147_increased_porphyrin_level1.03179200
100MP0009250_abnormal_appendicular_skeleto1.02710255
101MP0005410_abnormal_fertilization1.02602942
102MP0003953_abnormal_hormone_level1.02524097
103MP0000569_abnormal_digit_pigmentation1.02499465
104MP0000631_abnormal_neuroendocrine_gland1.00673439
105MP0000537_abnormal_urethra_morphology1.00404503
106MP0000383_abnormal_hair_follicle0.98908235
107MP0000955_abnormal_spinal_cord0.98535317
108MP0008775_abnormal_heart_ventricle0.98371987
109MP0005220_abnormal_exocrine_pancreas0.97523589
110MP0005408_hypopigmentation0.97411042
111MP0000462_abnormal_digestive_system0.95395286
112MP0002069_abnormal_eating/drinking_beha0.92834908
113MP0010030_abnormal_orbit_morphology0.92753235
114MP0003787_abnormal_imprinting0.92636081
115MP0002184_abnormal_innervation0.92042099
116MP0003122_maternal_imprinting0.91801255
117MP0001963_abnormal_hearing_physiology0.91545223
118MP0000427_abnormal_hair_cycle0.89936538
119MP0005377_hearing/vestibular/ear_phenot0.89751665
120MP0003878_abnormal_ear_physiology0.89751665
121MP0004782_abnormal_surfactant_physiolog0.89141180
122MP0005365_abnormal_bile_salt0.89096292
123MP0003868_abnormal_feces_composition0.88601636
124MP0005551_abnormal_eye_electrophysiolog0.87299333
125MP0005084_abnormal_gallbladder_morpholo0.85464165
126MP0005636_abnormal_mineral_homeostasis0.84163248
127MP0002882_abnormal_neuron_morphology0.83423308
128MP0004924_abnormal_behavior0.83332286
129MP0005386_behavior/neurological_phenoty0.83332286
130MP0000230_abnormal_systemic_arterial0.80523230
131MP0004142_abnormal_muscle_tone0.80095871
132MP0002229_neurodegeneration0.79742325
133MP0009384_cardiac_valve_regurgitation0.77992905
134MP0000026_abnormal_inner_ear0.77886134
135MP0004019_abnormal_vitamin_homeostasis0.77674020
136MP0004885_abnormal_endolymph0.76100699
137MP0002066_abnormal_motor_capabilities/c0.75627377
138MP0005085_abnormal_gallbladder_physiolo0.75109456
139MP0003633_abnormal_nervous_system0.74942839
140MP0002928_abnormal_bile_duct0.74377724
141MP0004264_abnormal_extraembryonic_tissu0.73523279
142MP0005253_abnormal_eye_physiology0.73367986
143MP0008569_lethality_at_weaning0.73311150

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.88907951
2Decreased circulating renin level (HP:0003351)4.52891421
3Hypoglycemic seizures (HP:0002173)4.24039279
4Hyperinsulinemic hypoglycemia (HP:0000825)4.08926877
5Nephronophthisis (HP:0000090)4.00084576
6Hyperactive renin-angiotensin system (HP:0000841)3.93942844
7Symptomatic seizures (HP:0011145)3.68534979
8Conjugated hyperbilirubinemia (HP:0002908)3.50895144
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.42662635
10Unilateral renal agenesis (HP:0000122)3.41948655
11Focal motor seizures (HP:0011153)3.35034867
12Abnormality of renin-angiotensin system (HP:0000847)3.31938655
13Abnormality of the renal medulla (HP:0100957)3.23584392
14Large for gestational age (HP:0001520)3.23111016
15Absent eyebrow (HP:0002223)3.12982825
16Abnormality of calcium-phosphate metabolism (HP:0100530)3.10339711
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.03539749
18Absent/shortened dynein arms (HP:0200106)3.03539749
19Abnormal ciliary motility (HP:0012262)2.99484431
20Medial flaring of the eyebrow (HP:0010747)2.90192300
21Abnormality of the proximal phalanges of the hand (HP:0009834)2.84594190
22Hyperaldosteronism (HP:0000859)2.82032965
23Hyperkalemia (HP:0002153)2.81180271
24Hyperventilation (HP:0002883)2.78440566
25Osteomalacia (HP:0002749)2.77904863
26Insulin-resistant diabetes mellitus (HP:0000831)2.77359011
27Congenital stationary night blindness (HP:0007642)2.73557954
28Hyperphosphatemia (HP:0002905)2.68900259
29Sclerocornea (HP:0000647)2.65615315
30Hypoglycemic coma (HP:0001325)2.65257310
31Ketoacidosis (HP:0001993)2.62274306
32Nephrogenic diabetes insipidus (HP:0009806)2.62078004
33Tubulointerstitial nephritis (HP:0001970)2.60833360
34Progressive cerebellar ataxia (HP:0002073)2.60440655
35Metabolic alkalosis (HP:0200114)2.58564139
36Epileptic encephalopathy (HP:0200134)2.58379639
37Hyperglycemia (HP:0003074)2.52415483
38Abnormality of the fovea (HP:0000493)2.52299138
39Hypokalemia (HP:0002900)2.52297819
40Humeroradial synostosis (HP:0003041)2.52281241
41Synostosis involving the elbow (HP:0003938)2.52281241
42Abnormality of dental color (HP:0011073)2.51810925
43Tubular atrophy (HP:0000092)2.51655710
44Anencephaly (HP:0002323)2.49781699
45Pendular nystagmus (HP:0012043)2.48074801
46Hypothermia (HP:0002045)2.46531203
47Abnormality of the middle phalanges of the toes (HP:0010183)2.45882355
48Epileptiform EEG discharges (HP:0011182)2.44279499
49Abnormal respiratory motile cilium physiology (HP:0012261)2.43875988
50Febrile seizures (HP:0002373)2.43635158
51Congenital primary aphakia (HP:0007707)2.35173443
52Abnormality of potassium homeostasis (HP:0011042)2.34860290
53Chronic bronchitis (HP:0004469)2.34458371
54Congenital hepatic fibrosis (HP:0002612)2.32659410
55EEG with generalized epileptiform discharges (HP:0011198)2.32152907
56Cortical visual impairment (HP:0100704)2.31930391
57Gait imbalance (HP:0002141)2.31221058
58Postaxial foot polydactyly (HP:0001830)2.30879908
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.30788372
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.30728339
61Hypoplasia of the fovea (HP:0007750)2.30728339
62Male pseudohermaphroditism (HP:0000037)2.30288994
63Concave nail (HP:0001598)2.29959673
64Visual hallucinations (HP:0002367)2.28167662
65Short femoral neck (HP:0100864)2.24079591
66Short 1st metacarpal (HP:0010034)2.23740250
67Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.23740250
68True hermaphroditism (HP:0010459)2.23302537
69Asplenia (HP:0001746)2.22135580
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.21711308
71Abnormality of chloride homeostasis (HP:0011422)2.21568778
72Mitochondrial inheritance (HP:0001427)2.19204751
73Chronic hepatic failure (HP:0100626)2.18192096
74Hypokalemic alkalosis (HP:0001949)2.18082026
75Hypsarrhythmia (HP:0002521)2.17592120
76Symphalangism affecting the phalanges of the hand (HP:0009773)2.17216806
77Pancreatic fibrosis (HP:0100732)2.16269453
78Tetany (HP:0001281)2.16245171
79Abnormality of the renal cortex (HP:0011035)2.16237279
80Congenital sensorineural hearing impairment (HP:0008527)2.15573883
81Bronchiectasis (HP:0002110)2.15307850
82Hepatocellular necrosis (HP:0001404)2.15003924
83Abnormal respiratory epithelium morphology (HP:0012253)2.14404217
84Abnormal respiratory motile cilium morphology (HP:0005938)2.14404217
85Abnormality of polysaccharide metabolism (HP:0011012)2.12232837
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12232837
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12232837
88Aplasia/hypoplasia of the uterus (HP:0008684)2.11991934
89Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.09903994
90Generalized aminoaciduria (HP:0002909)2.08850709
91Increased circulating renin level (HP:0000848)2.06584710
92Absent eyelashes (HP:0000561)2.04984566
93Retinal dysplasia (HP:0007973)2.04675872
94Rhinitis (HP:0012384)2.04103757
95Polyphagia (HP:0002591)2.03524845
96Absent speech (HP:0001344)2.03132339
97Furrowed tongue (HP:0000221)2.02356412
98Abnormal number of erythroid precursors (HP:0012131)2.01099632
99Aplasia/Hypoplasia of the patella (HP:0006498)1.99956927
100Agitation (HP:0000713)1.99931151
101Cystic liver disease (HP:0006706)1.99405038
102Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.98368540
103Increased corneal curvature (HP:0100692)1.97893268
104Keratoconus (HP:0000563)1.97893268
105Abolished electroretinogram (ERG) (HP:0000550)1.97096157
106Abnormal rod and cone electroretinograms (HP:0008323)1.96035644
107Postaxial hand polydactyly (HP:0001162)1.95877053
108Hypoplasia of the uterus (HP:0000013)1.95279260
109Occipital encephalocele (HP:0002085)1.95006998
110Optic nerve hypoplasia (HP:0000609)1.94290998
111Abnormality of the 1st metacarpal (HP:0010009)1.93559118
112Protruding tongue (HP:0010808)1.93336217
113Retinal atrophy (HP:0001105)1.91883814
114Pancreatic islet-cell hyperplasia (HP:0004510)1.91773093
115Specific learning disability (HP:0001328)1.91030730
116Poor coordination (HP:0002370)1.90499031
117Increased CSF lactate (HP:0002490)1.90033303
118Decreased central vision (HP:0007663)1.89858451
119Adrenal hypoplasia (HP:0000835)1.88944047
120Abnormal biliary tract physiology (HP:0012439)1.88090623
121Bile duct proliferation (HP:0001408)1.88090623
122Parakeratosis (HP:0001036)1.87439286
123Short hallux (HP:0010109)1.87387033
124Acute necrotizing encephalopathy (HP:0006965)1.86912316
125Hepatic necrosis (HP:0002605)1.86887773
126Abnormality of the phalanges of the 5th finger (HP:0004213)1.86493160
127Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86124220
128Patellar aplasia (HP:0006443)1.86009129
129Septo-optic dysplasia (HP:0100842)1.85843176
130Generalized tonic-clonic seizures (HP:0002069)1.84663034
131Aplasia/Hypoplasia of the hallux (HP:0008362)1.84622814
132Abnormality of cells of the erythroid lineage (HP:0012130)1.83377130
133Genetic anticipation (HP:0003743)1.82597640
134Severe muscular hypotonia (HP:0006829)1.82316077
135Progressive macrocephaly (HP:0004481)1.82050673
136Abnormal hair whorl (HP:0010721)1.81482378
137Polydipsia (HP:0001959)1.81376673
138Abnormal drinking behavior (HP:0030082)1.81376673
139Vaginal atresia (HP:0000148)1.80661880
140Fibular aplasia (HP:0002990)1.80542388
141Genital tract atresia (HP:0001827)1.80013928
142Mucopolysacchariduria (HP:0008155)1.79465528
143Urinary glycosaminoglycan excretion (HP:0003541)1.79465528
144Abnormal mitochondria in muscle tissue (HP:0008316)1.79307130
145Morphological abnormality of the middle ear (HP:0008609)1.79001187
146Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78090254
147Molar tooth sign on MRI (HP:0002419)1.77241932
148Abnormality of midbrain morphology (HP:0002418)1.77241932
149Alkalosis (HP:0001948)1.77241435
150Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.75760070
151Bradycardia (HP:0001662)1.75522831
152Type II lissencephaly (HP:0007260)1.74114698
153Renal dysplasia (HP:0000110)1.73420602
154Lissencephaly (HP:0001339)1.73219215
155Abnormality of the nasal septum (HP:0000419)1.72998816
156Failure to thrive in infancy (HP:0001531)1.71449817
157Congenital, generalized hypertrichosis (HP:0004540)1.70910255
158Generalized hypopigmentation of hair (HP:0011358)1.70815858
159Hypoplastic pelvis (HP:0008839)1.70462916
160Preaxial hand polydactyly (HP:0001177)1.68217525
161Ketosis (HP:0001946)1.67834329
162Synostosis of carpal bones (HP:0005048)1.67433123
163Myokymia (HP:0002411)1.67332472
164Patchy hypopigmentation of hair (HP:0011365)1.66882239
165Acute encephalopathy (HP:0006846)1.65721408
166Pancreatic cysts (HP:0001737)1.65207041
167Disproportionate short-trunk short stature (HP:0003521)1.64345869
168Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62666538
169Abnormality of endocrine pancreas physiology (HP:0012093)1.61361494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.19883655
2SIK33.92863287
3CASK3.70506027
4MAPK153.67665289
5NTRK33.17439599
6EPHA42.21200906
7TLK12.18167563
8MAP2K72.14315897
9GRK12.13535226
10AKT32.11909194
11SIK22.01508867
12STK161.99464725
13MAPKAPK31.92310772
14BMPR21.92254550
15SIK11.90494553
16RIPK41.81583018
17PASK1.78362398
18DYRK21.75170022
19ADRBK21.74960588
20MARK11.67840919
21BMPR1B1.65454875
22PRPF4B1.64642184
23MAP3K131.53297752
24TAOK31.52886871
25WNK31.51621057
26MAP3K121.51301922
27PINK11.50021976
28MAP3K21.46980589
29CAMKK21.43986570
30MARK31.43344295
31FRK1.39149437
32NTRK11.39137328
33TNIK1.36917340
34NEK61.29093454
35FER1.27524594
36IRAK31.24114595
37IRAK21.19335654
38EPHA21.18457714
39MAP3K41.16740454
40PRKD31.15136997
41GRK71.14112778
42CSNK1G21.11576413
43CDK81.08335568
44BCKDK1.07281131
45SGK2231.04259661
46SGK4941.04259661
47BRAF1.04167378
48MAP3K91.03364380
49IRAK11.03360761
50MAP2K61.03127526
51PIK3CA1.02092792
52PRKCE1.01153463
53TNK20.99614687
54PLK20.99479847
55PRKCG0.97374332
56MUSK0.96850102
57IRAK40.96098666
58SGK20.95868309
59NEK20.95788566
60MAPK130.95770340
61PKN10.94565639
62FGFR20.94302205
63RPS6KA50.91061864
64BRD40.90542524
65RPS6KA60.89757215
66ZAK0.89123177
67WNK40.87981026
68CSNK1G30.87932969
69PNCK0.86362023
70PIM20.85771499
71GRK50.84811751
72EPHA30.83405574
73PHKG20.82260209
74PHKG10.82260209
75TGFBR10.81262966
76RPS6KA20.81031692
77ERBB20.79538100
78OXSR10.77573406
79MET0.76693209
80WEE10.75879115
81CSNK1A1L0.75739620
82NUAK10.75689493
83VRK10.75679407
84PAK30.75381049
85ACVR1B0.74184260
86HIPK20.73966101
87WNK10.73691594
88DAPK20.73638388
89DYRK1B0.69418419
90AURKA0.69167788
91ARAF0.68953332
92CDC42BPA0.68704982
93CDK50.68399317
94PRKAA10.67657165
95CSNK1G10.67616859
96CAMK2A0.66963132
97MAP3K10.66299955
98EPHB20.65071355
99MAP2K40.62231295
100NTRK20.61258256
101CAMK2B0.60888193
102STK38L0.60856309
103DYRK30.60044844
104NME10.59953297
105UHMK10.59908809
106CSNK1A10.58115446
107MAP3K140.57319694
108FLT30.56602747
109PIK3CG0.56475789
110SGK10.56372271
111LMTK20.53647218
112PTK2B0.53325768
113MAP3K70.52899777
114ABL20.51709760
115PLK10.51032429
116PRKACA0.50731317
117PRKD20.50702939
118PRKCZ0.50546489
119LIMK10.50536113
120RPS6KL10.50054109
121RPS6KC10.50054109
122KSR10.49811172
123CAMK2D0.49496332
124MARK20.48755763
125CAMK10.47764207
126DYRK1A0.47418497
127ERBB30.47197309
128STK390.46066314
129MINK10.45578103
130CDK30.44584235
131MAP2K10.44082494
132PRKCQ0.43879683
133MAP4K20.43867432
134DAPK10.43792475
135TIE10.43696178
136MAPK70.42809983
137CAMK1D0.41115015
138MKNK20.40919149
139ATR0.40911052
140MAP2K20.40876297
141PRKCA0.40008668
142YES10.38778627
143CDK190.38645892
144STK380.37308480
145ADRBK10.36852615
146BRSK20.36385840
147CAMK2G0.35701002
148PRKG10.35475321
149MYLK0.34200098
150BCR0.34198538
151PRKCI0.33350790

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.89804160
2Nicotine addiction_Homo sapiens_hsa050333.00307071
3Insulin secretion_Homo sapiens_hsa049112.82269146
4Taste transduction_Homo sapiens_hsa047422.80879816
5Protein export_Homo sapiens_hsa030602.79971419
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37890048
7Synaptic vesicle cycle_Homo sapiens_hsa047212.33143794
8Collecting duct acid secretion_Homo sapiens_hsa049662.30328361
9Sulfur metabolism_Homo sapiens_hsa009202.23232788
10Ribosome_Homo sapiens_hsa030102.10951179
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09098635
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05772658
13Vibrio cholerae infection_Homo sapiens_hsa051102.03433427
14Morphine addiction_Homo sapiens_hsa050322.00646255
15Circadian entrainment_Homo sapiens_hsa047131.92001773
16GABAergic synapse_Homo sapiens_hsa047271.89618926
17Amphetamine addiction_Homo sapiens_hsa050311.85894793
18Type II diabetes mellitus_Homo sapiens_hsa049301.81849726
19Nitrogen metabolism_Homo sapiens_hsa009101.80474613
20Serotonergic synapse_Homo sapiens_hsa047261.80232370
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80214209
22Chemical carcinogenesis_Homo sapiens_hsa052041.71397391
23Cocaine addiction_Homo sapiens_hsa050301.70198366
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69236280
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65246394
26Glutamatergic synapse_Homo sapiens_hsa047241.55377391
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48411288
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47276897
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45976794
30Olfactory transduction_Homo sapiens_hsa047401.43280360
31Other glycan degradation_Homo sapiens_hsa005111.42352709
32Oxidative phosphorylation_Homo sapiens_hsa001901.37599588
33Sulfur relay system_Homo sapiens_hsa041221.36413201
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35978084
35Caffeine metabolism_Homo sapiens_hsa002321.32029032
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31613139
37RNA polymerase_Homo sapiens_hsa030201.31597480
38Pancreatic secretion_Homo sapiens_hsa049721.30869890
39Peroxisome_Homo sapiens_hsa041461.30771577
40Calcium signaling pathway_Homo sapiens_hsa040201.29434839
41Fanconi anemia pathway_Homo sapiens_hsa034601.23444280
42Salivary secretion_Homo sapiens_hsa049701.23410306
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18705702
44Type I diabetes mellitus_Homo sapiens_hsa049401.18669456
45Dopaminergic synapse_Homo sapiens_hsa047281.16875968
46Retinol metabolism_Homo sapiens_hsa008301.16497241
47Long-term potentiation_Homo sapiens_hsa047201.15271160
48Basal cell carcinoma_Homo sapiens_hsa052171.14059089
49Renin secretion_Homo sapiens_hsa049241.13329990
50Cholinergic synapse_Homo sapiens_hsa047251.12760846
51Homologous recombination_Homo sapiens_hsa034401.09954710
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04993317
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04667882
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.04141188
55Sphingolipid metabolism_Homo sapiens_hsa006001.03103274
56Tyrosine metabolism_Homo sapiens_hsa003501.02170375
57Regulation of autophagy_Homo sapiens_hsa041401.02082466
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00888840
59N-Glycan biosynthesis_Homo sapiens_hsa005100.99758288
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99064647
61Lysosome_Homo sapiens_hsa041420.98994059
62Circadian rhythm_Homo sapiens_hsa047100.93926273
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92992264
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92393661
65Hedgehog signaling pathway_Homo sapiens_hsa043400.92140381
66Fructose and mannose metabolism_Homo sapiens_hsa000510.90426373
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90367525
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.89522513
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88802136
70Alzheimers disease_Homo sapiens_hsa050100.88032297
71RNA degradation_Homo sapiens_hsa030180.87381699
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.86912926
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84928601
74cAMP signaling pathway_Homo sapiens_hsa040240.84037118
75Gastric acid secretion_Homo sapiens_hsa049710.81565144
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81429392
77Rheumatoid arthritis_Homo sapiens_hsa053230.81275016
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80816248
79Long-term depression_Homo sapiens_hsa047300.80632006
80Axon guidance_Homo sapiens_hsa043600.79958449
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79632366
82Butanoate metabolism_Homo sapiens_hsa006500.78605822
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77760189
84Folate biosynthesis_Homo sapiens_hsa007900.75645678
85Fatty acid biosynthesis_Homo sapiens_hsa000610.75283076
86Thyroid hormone synthesis_Homo sapiens_hsa049180.73576767
87Basal transcription factors_Homo sapiens_hsa030220.73111959
88Histidine metabolism_Homo sapiens_hsa003400.71780266
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71023259
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.69946636
91ABC transporters_Homo sapiens_hsa020100.69843689
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67643189
93Phototransduction_Homo sapiens_hsa047440.67241894
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66960286
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66424047
96Glycerolipid metabolism_Homo sapiens_hsa005610.66364025
97Mineral absorption_Homo sapiens_hsa049780.65791976
98Linoleic acid metabolism_Homo sapiens_hsa005910.65211112
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63208572
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62988126
101Glutathione metabolism_Homo sapiens_hsa004800.62870284
102Purine metabolism_Homo sapiens_hsa002300.62235913
103Fat digestion and absorption_Homo sapiens_hsa049750.62071752
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61665806
105Galactose metabolism_Homo sapiens_hsa000520.60322357
106Phagosome_Homo sapiens_hsa041450.60296647
107Starch and sucrose metabolism_Homo sapiens_hsa005000.59674027
108Propanoate metabolism_Homo sapiens_hsa006400.59276434
109Arachidonic acid metabolism_Homo sapiens_hsa005900.58433504
110Pyrimidine metabolism_Homo sapiens_hsa002400.58084511
111Glucagon signaling pathway_Homo sapiens_hsa049220.57289849
112Fatty acid elongation_Homo sapiens_hsa000620.55672102
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55416964
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.55148230
115Parkinsons disease_Homo sapiens_hsa050120.54125201
116Steroid biosynthesis_Homo sapiens_hsa001000.53326295
117beta-Alanine metabolism_Homo sapiens_hsa004100.53048731
118Huntingtons disease_Homo sapiens_hsa050160.51735638
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51554948
120Phenylalanine metabolism_Homo sapiens_hsa003600.50852115
121Ovarian steroidogenesis_Homo sapiens_hsa049130.50827863
122One carbon pool by folate_Homo sapiens_hsa006700.50095835
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49685198
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49123007
125Tryptophan metabolism_Homo sapiens_hsa003800.49098012
126Oxytocin signaling pathway_Homo sapiens_hsa049210.48998141
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.48021590
128Selenocompound metabolism_Homo sapiens_hsa004500.46667939
129Hippo signaling pathway_Homo sapiens_hsa043900.46304694
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45926412
131Inositol phosphate metabolism_Homo sapiens_hsa005620.44839122
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44595071
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42650246
134Ether lipid metabolism_Homo sapiens_hsa005650.41162781
135Fatty acid degradation_Homo sapiens_hsa000710.40932795
136Metabolic pathways_Homo sapiens_hsa011000.39973088
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39461468
138Arginine and proline metabolism_Homo sapiens_hsa003300.39216768
139Base excision repair_Homo sapiens_hsa034100.39052653
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38586503
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38128765
142Cardiac muscle contraction_Homo sapiens_hsa042600.36665292
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36568739
144Estrogen signaling pathway_Homo sapiens_hsa049150.36225559
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33841952

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