COG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPII vesicle coating (GO:0048208)6.05667170
2nuclear pore complex assembly (GO:0051292)5.80881227
3nuclear pore organization (GO:0006999)5.12213511
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.97711007
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.97711007
6positive regulation of gamma-delta T cell activation (GO:0046645)4.87144091
7regulation of gamma-delta T cell differentiation (GO:0045586)4.42005029
8antigen processing and presentation of endogenous antigen (GO:0019883)4.33198665
9interleukin-6-mediated signaling pathway (GO:0070102)4.31185988
10pore complex assembly (GO:0046931)4.30687220
11negative T cell selection (GO:0043383)4.21128033
12negative thymic T cell selection (GO:0045060)4.17588031
13Golgi to endosome transport (GO:0006895)4.14966188
14vesicle coating (GO:0006901)4.11995204
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.11460063
16tachykinin receptor signaling pathway (GO:0007217)4.06247545
17monoubiquitinated protein deubiquitination (GO:0035520)4.05204104
18regulation of gamma-delta T cell activation (GO:0046643)4.00505017
19protein K11-linked deubiquitination (GO:0035871)3.98772280
20dosage compensation (GO:0007549)3.75927703
21spliceosomal tri-snRNP complex assembly (GO:0000244)3.75828451
22negative regulation of histone methylation (GO:0031061)3.74347679
23mitotic sister chromatid cohesion (GO:0007064)3.72529694
24DNA unwinding involved in DNA replication (GO:0006268)3.68887127
25growth hormone receptor signaling pathway (GO:0060396)3.63650268
26Golgi organization (GO:0007030)3.62863420
27positive thymic T cell selection (GO:0045059)3.58974632
28phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.54898166
29peptidyl-lysine dimethylation (GO:0018027)3.52201686
30regulation of RNA export from nucleus (GO:0046831)3.50423227
31labyrinthine layer development (GO:0060711)3.49761255
32histone mRNA catabolic process (GO:0071044)3.49018141
33COPI coating of Golgi vesicle (GO:0048205)3.46954132
34Golgi transport vesicle coating (GO:0048200)3.46954132
35UDP-N-acetylglucosamine metabolic process (GO:0006047)3.46471697
36pre-miRNA processing (GO:0031054)3.44453982
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43341935
38iron ion import (GO:0097286)3.42267083
39mitotic nuclear envelope disassembly (GO:0007077)3.39972639
40oocyte development (GO:0048599)3.39891157
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38824224
42DNA duplex unwinding (GO:0032508)3.38085821
43DNA geometric change (GO:0032392)3.36884550
44genitalia morphogenesis (GO:0035112)3.36629936
45negative regulation of cell killing (GO:0031342)3.36170509
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36170509
47thymic T cell selection (GO:0045061)3.34860229
48nuclear envelope disassembly (GO:0051081)3.31322181
49membrane disassembly (GO:0030397)3.31322181
50protein localization to kinetochore (GO:0034501)3.31284295
51negative regulation of RNA splicing (GO:0033119)3.29480819
52T cell selection (GO:0045058)3.28426107
53cellular response to growth hormone stimulus (GO:0071378)3.24351968
54regulation of translational termination (GO:0006449)3.23945812
55positive T cell selection (GO:0043368)3.20148275
56regulation of DNA endoreduplication (GO:0032875)3.19113626
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.18298073
58positive regulation of B cell differentiation (GO:0045579)3.15459323
59pyrimidine dimer repair (GO:0006290)3.14961448
60regulation of nucleobase-containing compound transport (GO:0032239)3.08718208
61regulation of DNA methylation (GO:0044030)3.08347515
62protein localization to chromosome, centromeric region (GO:0071459)3.07143109
63establishment of protein localization to Golgi (GO:0072600)3.06967233
64regulation of histone H3-K9 methylation (GO:0051570)3.06432873
65snRNA processing (GO:0016180)3.04210221
66diterpenoid biosynthetic process (GO:0016102)3.02860587
67* intra-Golgi vesicle-mediated transport (GO:0006891)3.02574893
68DNA methylation involved in gamete generation (GO:0043046)2.99798267
69nucleus organization (GO:0006997)2.98169126
70NLS-bearing protein import into nucleus (GO:0006607)2.96738803
71interkinetic nuclear migration (GO:0022027)2.95364138
72cellular response to ethanol (GO:0071361)2.95033684
73protein targeting to Golgi (GO:0000042)2.93966720
74positive regulation of histone deacetylation (GO:0031065)2.93174582
75regulation of female gonad development (GO:2000194)2.93042046
76protein K48-linked deubiquitination (GO:0071108)2.91283521
77cytoplasmic mRNA processing body assembly (GO:0033962)2.89583287
78regulation of fibroblast apoptotic process (GO:2000269)2.88019763
79regulation of sister chromatid cohesion (GO:0007063)2.87894417
80translesion synthesis (GO:0019985)2.85060561
81snRNA metabolic process (GO:0016073)2.84278988
82regulation of relaxation of muscle (GO:1901077)2.82272029
83regulation of B cell receptor signaling pathway (GO:0050855)2.81862236
84response to interleukin-15 (GO:0070672)2.80987029
85response to lipoprotein particle (GO:0055094)2.80669976
86definitive hemopoiesis (GO:0060216)2.79800877
87glucocorticoid receptor signaling pathway (GO:0042921)2.79411548
88ER to Golgi vesicle-mediated transport (GO:0006888)2.79386553
89antigen processing and presentation via MHC class Ib (GO:0002475)2.79078568
90mitotic chromosome condensation (GO:0007076)2.76455740
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.76037923
92negative regulation of mRNA metabolic process (GO:1903312)2.74945966
93piRNA metabolic process (GO:0034587)2.72331283
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71747403
95ribosome assembly (GO:0042255)2.69075946
96bundle of His cell to Purkinje myocyte communication (GO:0086069)2.67108184
97nuclear envelope organization (GO:0006998)2.67067115
98regulation of steroid hormone secretion (GO:2000831)2.66987785
99coronary vasculature morphogenesis (GO:0060977)2.64995404
100negative regulation of mRNA processing (GO:0050686)2.64432150
101regulation of histone H3-K27 methylation (GO:0061085)2.64156297
102fibroblast migration (GO:0010761)2.64142992
103B cell receptor signaling pathway (GO:0050853)2.63947248
104protein targeting to vacuole (GO:0006623)2.61769856
105protein targeting to lysosome (GO:0006622)2.61769856
106establishment of protein localization to vacuole (GO:0072666)2.61769856
107histone lysine demethylation (GO:0070076)2.61514901
108folic acid-containing compound biosynthetic process (GO:0009396)2.61057181
109histone H3-K36 demethylation (GO:0070544)2.60716770
110protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.60371841
111regulation of growth hormone secretion (GO:0060123)2.57214498
112regulation of B cell differentiation (GO:0045577)2.56306596
113regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.56280650
114spermatid nucleus differentiation (GO:0007289)2.56258731
115regulation of NFAT protein import into nucleus (GO:0051532)2.55806348
116negative regulation of histone modification (GO:0031057)2.55425738
117alternative mRNA splicing, via spliceosome (GO:0000380)2.55372743
118ncRNA 3-end processing (GO:0043628)2.55156561
119regulation of translational fidelity (GO:0006450)2.55093592
120Golgi to plasma membrane protein transport (GO:0043001)2.51635196
121regulation of chromatin silencing (GO:0031935)2.51462870
122histone demethylation (GO:0016577)2.50774311
123regulation of T cell tolerance induction (GO:0002664)2.50655398
124IMP biosynthetic process (GO:0006188)2.50308374
125DNA conformation change (GO:0071103)2.50132461
126meiotic cell cycle (GO:0051321)2.49564023
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49285597
128positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49285597
129positive regulation of mitotic sister chromatid separation (GO:1901970)2.49285597
130multicellular organism reproduction (GO:0032504)2.48830012
131early endosome to late endosome transport (GO:0045022)2.48522736
132positive regulation of growth hormone secretion (GO:0060124)2.48301424
133macroautophagy (GO:0016236)2.48144457
134necroptotic process (GO:0070266)2.46910097
135sister chromatid segregation (GO:0000819)2.46833017
136corticosteroid receptor signaling pathway (GO:0031958)2.46668809
137regulation of steroid hormone biosynthetic process (GO:0090030)2.46240291
138acrosome assembly (GO:0001675)2.45590702
139negative regulation of DNA repair (GO:0045738)2.44680687
140retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.44251630
141natural killer cell differentiation (GO:0001779)2.43764042
142T cell homeostasis (GO:0043029)2.42857415
143negative regulation of chromatin modification (GO:1903309)2.42030299
144regulation of mitotic spindle organization (GO:0060236)2.41759797
145regulation of centriole replication (GO:0046599)2.41675091
146regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.39516794
147platelet-derived growth factor receptor signaling pathway (GO:0048008)2.39330935
148auditory receptor cell differentiation (GO:0042491)2.37052721
149androgen receptor signaling pathway (GO:0030521)2.36987211
150biotin metabolic process (GO:0006768)2.36968476
151regulation of acrosome reaction (GO:0060046)2.35668929
152DNA damage induced protein phosphorylation (GO:0006975)2.35095023
153regulation of spindle organization (GO:0090224)2.34541941
154mRNA cleavage (GO:0006379)2.33738615
155embryonic process involved in female pregnancy (GO:0060136)2.33304922
156histone-serine phosphorylation (GO:0035404)2.32503270
157histone H3-K9 demethylation (GO:0033169)2.32058946
158retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31363390
159microtubule anchoring (GO:0034453)2.31020109
160histone H3-K4 methylation (GO:0051568)2.30899546
161histone phosphorylation (GO:0016572)2.30065028
162DNA replication-dependent nucleosome organization (GO:0034723)2.30061486
163DNA replication-dependent nucleosome assembly (GO:0006335)2.30061486
164nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.29855066
165attachment of spindle microtubules to kinetochore (GO:0008608)2.29031647
166pericardium development (GO:0060039)2.28907842
167retinal cone cell development (GO:0046549)2.28738897
168morphogenesis of an endothelium (GO:0003159)2.28227490
169endothelial tube morphogenesis (GO:0061154)2.28227490
170embryonic hemopoiesis (GO:0035162)2.27082709
171gene silencing by RNA (GO:0031047)2.25515127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90828257
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.52235644
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.43559710
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.25437202
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.85996023
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75098776
7MYC_22102868_ChIP-Seq_BL_Human3.54249134
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50268680
9GATA1_22025678_ChIP-Seq_K562_Human3.17610588
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.06848044
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.06743052
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79076330
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71069490
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59667351
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.53116922
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35830219
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35207376
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18454975
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.14226421
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.13074447
21* WT1_19549856_ChIP-ChIP_CCG9911_Human2.11270677
22CIITA_25753668_ChIP-Seq_RAJI_Human2.06662604
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05302508
24MYB_26560356_Chip-Seq_TH2_Human2.00132942
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99295939
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96805276
27RUNX_20019798_ChIP-Seq_JUKART_Human1.96515011
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.95098754
29MYB_26560356_Chip-Seq_TH1_Human1.92486527
30TCF7_22412390_ChIP-Seq_EML_Mouse1.89704696
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87291236
32UTX_26944678_Chip-Seq_JUKART_Human1.85777226
33SCL_19346495_ChIP-Seq_HPC-7_Human1.84816328
34MAF_26560356_Chip-Seq_TH1_Human1.83417158
35VDR_21846776_ChIP-Seq_THP-1_Human1.81906743
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.78263118
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73285314
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71296893
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70150070
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70142718
41* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.67173648
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.63082005
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62557902
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.61870510
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.61859572
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61748089
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.61665145
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58554047
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58554047
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58201416
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55906191
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55831149
53GBX2_23144817_ChIP-Seq_PC3_Human1.54002429
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53145951
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52418850
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51908054
57FUS_26573619_Chip-Seq_HEK293_Human1.50996532
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50901870
59TAF15_26573619_Chip-Seq_HEK293_Human1.50775710
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50517981
61SMAD4_21799915_ChIP-Seq_A2780_Human1.49880036
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49040457
63* STAT3_23295773_ChIP-Seq_U87_Human1.47684345
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.46789965
65GATA3_27048872_Chip-Seq_THYMUS_Human1.43010457
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42656161
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41385383
68SPI1_23127762_ChIP-Seq_K562_Human1.41134636
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40900340
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40539853
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38049721
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37937080
73CBP_20019798_ChIP-Seq_JUKART_Human1.37937080
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37527320
75KDM2B_26808549_Chip-Seq_DND41_Human1.37466636
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37426754
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37300996
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37213785
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36420541
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.36198038
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36089083
82* ER_23166858_ChIP-Seq_MCF-7_Human1.35861431
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.35264384
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34655872
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33899317
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33727135
87CJUN_26792858_Chip-Seq_BT549_Human1.33659927
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31077851
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31077851
90CDX2_22108803_ChIP-Seq_LS180_Human1.30070468
91SALL4_22934838_ChIP-ChIP_CD34+_Human1.29473683
92* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28747458
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28663004
94AR_21909140_ChIP-Seq_LNCAP_Human1.27623193
95EWS_26573619_Chip-Seq_HEK293_Human1.27084067
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26774680
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26133889
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23997392
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23572710
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22880740
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.21844026
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20715109
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20641287
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20441598
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.20063792
106* TFEB_21752829_ChIP-Seq_HELA_Human1.19837274
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19775904
108EZH2_22144423_ChIP-Seq_EOC_Human1.19739628
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19183589
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18953281
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18739261
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18223792
113IGF1R_20145208_ChIP-Seq_DFB_Human1.17955026
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.17914867
115TCF4_23295773_ChIP-Seq_U87_Human1.17893964
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17636545
117CLOCK_20551151_ChIP-Seq_293T_Human1.17155119
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16740780
119ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13969719
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13936878
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13793553
122PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13415047
123TP53_16413492_ChIP-PET_HCT116_Human1.13337661
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.11216299
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.10632866
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10470011
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10277552
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10126343
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09898243
130NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07912813
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07231270
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06665529
133MYC_18555785_ChIP-Seq_MESCs_Mouse1.06537895
134P300_19829295_ChIP-Seq_ESCs_Human1.06318847
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06156853
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05601723
137* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04395463
138VDR_24763502_ChIP-Seq_THP-1_Human1.03931062
139TP63_23658742_ChIP-Seq_EP156T_Human1.03597009
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02960397
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02708012
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02473425
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01659616
144KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00942847
145SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00861362
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00612082
147AHR_22903824_ChIP-Seq_MCF-7_Human0.99883046
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99754687
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99359025
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.99311638
151PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98903523
152GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98134368
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98019162
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97928624
155FOXP3_21729870_ChIP-Seq_TREG_Human0.97915342
156SPI1_23547873_ChIP-Seq_NB4_Human0.97741464
157P53_22387025_ChIP-Seq_ESCs_Mouse0.97352450
158KDM5A_27292631_Chip-Seq_BREAST_Human0.95762083
159MAF_26560356_Chip-Seq_TH2_Human0.94307956
160PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93269968
161BRD4_25478319_ChIP-Seq_HGPS_Human0.92070510
162FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91831631
163TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91438410
164SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90932884
165FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89796371
166ZNF263_19887448_ChIP-Seq_K562_Human0.89174877
167HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88317565
168GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87893028
169IRF8_27001747_Chip-Seq_BMDM_Mouse0.87359794
170ELK1_19687146_ChIP-ChIP_HELA_Human0.85816081
171* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85598083
172VDR_23849224_ChIP-Seq_CD4+_Human0.85115537
173MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85069432
174* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84337177
175TP63_19390658_ChIP-ChIP_HaCaT_Human0.82380342
176MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81645079
177CHD1_26751641_Chip-Seq_LNCaP_Human0.81513668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.95171610
2MP0003950_abnormal_plasma_membrane3.44429839
3MP0002166_altered_tumor_susceptibility3.42662334
4MP0003763_abnormal_thymus_physiology3.00139867
5MP0003300_gastrointestinal_ulcer2.83165759
6MP0002396_abnormal_hematopoietic_system2.82988358
7MP0008438_abnormal_cutaneous_collagen2.82832256
8MP0006054_spinal_hemorrhage2.68349690
9MP0010352_gastrointestinal_tract_polyps2.67555322
10MP0004808_abnormal_hematopoietic_stem2.45235197
11MP0005275_abnormal_skin_tensile2.33419795
12MP0010307_abnormal_tumor_latency2.29182597
13MP0002006_tumorigenesis2.27914136
14MP0010094_abnormal_chromosome_stability2.26326452
15MP0005076_abnormal_cell_differentiation2.22936977
16MP0010678_abnormal_skin_adnexa2.19620359
17MP0003718_maternal_effect2.18446906
18MP0003656_abnormal_erythrocyte_physiolo2.09102225
19MP0003077_abnormal_cell_cycle2.07850720
20MP0001835_abnormal_antigen_presentation2.06755390
21MP0003693_abnormal_embryo_hatching2.04541146
22MP0008007_abnormal_cellular_replicative1.97333721
23MP0000703_abnormal_thymus_morphology1.95325135
24MP0003111_abnormal_nucleus_morphology1.95114587
25MP0002398_abnormal_bone_marrow1.94257253
26MP0001873_stomach_inflammation1.86874865
27MP0004272_abnormal_basement_membrane1.86095273
28MP0000685_abnormal_immune_system1.85387879
29MP0008057_abnormal_DNA_replication1.85129446
30MP0001800_abnormal_humoral_immune1.77428324
31MP0002877_abnormal_melanocyte_morpholog1.76283858
32MP0003252_abnormal_bile_duct1.76110207
33MP0003941_abnormal_skin_development1.74286531
34MP0004084_abnormal_cardiac_muscle1.74135253
35MP0004036_abnormal_muscle_relaxation1.73502881
36MP0002009_preneoplasia1.67697996
37MP0003183_abnormal_peptide_metabolism1.67235465
38MP0005671_abnormal_response_to1.65265855
39MP0003868_abnormal_feces_composition1.61576424
40MP0008775_abnormal_heart_ventricle1.59066427
41MP0003787_abnormal_imprinting1.57273145
42MP0001730_embryonic_growth_arrest1.51723666
43MP0002722_abnormal_immune_system1.50726875
44MP0005503_abnormal_tendon_morphology1.50116023
45MP0005395_other_phenotype1.47954304
46MP0000716_abnormal_immune_system1.47940174
47MP0003172_abnormal_lysosome_physiology1.47841049
48MP0003121_genomic_imprinting1.46907955
49MP0003705_abnormal_hypodermis_morpholog1.45851186
50MP0004510_myositis1.42816697
51MP0008260_abnormal_autophagy1.42390056
52MP0000689_abnormal_spleen_morphology1.41680611
53MP0000465_gastrointestinal_hemorrhage1.41007905
54MP0001879_abnormal_lymphatic_vessel1.40460755
55MP0002088_abnormal_embryonic_growth/wei1.40244911
56MP0003984_embryonic_growth_retardation1.40146806
57MP0000383_abnormal_hair_follicle1.39616644
58MP0002420_abnormal_adaptive_immunity1.39115746
59MP0004957_abnormal_blastocyst_morpholog1.35982361
60MP0003566_abnormal_cell_adhesion1.35524158
61MP0001819_abnormal_immune_cell1.35502179
62MP0002429_abnormal_blood_cell1.34028563
63MP0004233_abnormal_muscle_weight1.33976852
64MP0002452_abnormal_antigen_presenting1.33920005
65MP0006138_congestive_heart_failure1.33182956
66MP0005248_abnormal_Harderian_gland1.33128473
67MP0000350_abnormal_cell_proliferation1.32399338
68MP0004484_altered_response_of1.32182089
69MP0002086_abnormal_extraembryonic_tissu1.31638965
70MP0010630_abnormal_cardiac_muscle1.31209874
71MP0010368_abnormal_lymphatic_system1.30341895
72MP0004043_abnormal_pH_regulation1.29302720
73MP0003943_abnormal_hepatobiliary_system1.28613046
74MP0003195_calcinosis1.27482451
75MP0001672_abnormal_embryogenesis/_devel1.27102261
76MP0005380_embryogenesis_phenotype1.27102261
77MP0001790_abnormal_immune_system1.27033079
78MP0005387_immune_system_phenotype1.27033079
79MP0000013_abnormal_adipose_tissue1.23992017
80MP0008877_abnormal_DNA_methylation1.19865568
81MP0000371_diluted_coat_color1.19403259
82MP0003828_pulmonary_edema1.19299222
83MP0010234_abnormal_vibrissa_follicle1.18948438
84MP0004197_abnormal_fetal_growth/weight/1.18554621
85MP0002723_abnormal_immune_serum1.18372885
86MP0003279_aneurysm1.17354105
87MP0003045_fibrosis1.14987298
88MP0001697_abnormal_embryo_size1.12383361
89MP0010155_abnormal_intestine_physiology1.11696696
90MP0002269_muscular_atrophy1.08554596
91MP0005464_abnormal_platelet_physiology1.08170309
92MP0002080_prenatal_lethality1.06990124
93MP0009697_abnormal_copulation1.06785946
94MP0002108_abnormal_muscle_morphology1.05548866
95MP0004134_abnormal_chest_morphology1.05026503
96MP0008058_abnormal_DNA_repair1.04636980
97MP0002019_abnormal_tumor_incidence1.03384851
98MP0002896_abnormal_bone_mineralization1.01796868
99MP0002168_other_aberrant_phenotype1.01717521
100MP0003866_abnormal_defecation1.01713555
101MP0000733_abnormal_muscle_development1.00712512
102MP0002928_abnormal_bile_duct0.99812729
103MP0000377_abnormal_hair_follicle0.99366551
104MP0005408_hypopigmentation0.97259324
105MP0003890_abnormal_embryonic-extraembry0.97077968
106MP0004264_abnormal_extraembryonic_tissu0.96987099
107MP0003115_abnormal_respiratory_system0.96110971
108MP0003191_abnormal_cellular_cholesterol0.95044688
109MP0004947_skin_inflammation0.94789384
110MP0004147_increased_porphyrin_level0.93426878
111MP0003221_abnormal_cardiomyocyte_apopto0.90575804
112MP0002084_abnormal_developmental_patter0.90344690
113MP0002933_joint_inflammation0.89522118
114MP0000427_abnormal_hair_cycle0.88991720
115MP0003091_abnormal_cell_migration0.87922194
116MP0003123_paternal_imprinting0.87360849
117MP0002060_abnormal_skin_morphology0.87215217
118MP0004130_abnormal_muscle_cell0.86604874
119MP0005187_abnormal_penis_morphology0.86130746
120MP0005397_hematopoietic_system_phenotyp0.85191680
121MP0001545_abnormal_hematopoietic_system0.85191680
122MP0002837_dystrophic_cardiac_calcinosis0.83824252
123MP0000266_abnormal_heart_morphology0.83676339
124MP0005621_abnormal_cell_physiology0.83328805
125MP0005000_abnormal_immune_tolerance0.82688929
126MP0008961_abnormal_basal_metabolism0.82033667
127MP0002972_abnormal_cardiac_muscle0.81578118
128MP0002925_abnormal_cardiovascular_devel0.80972971
129MP0002909_abnormal_adrenal_gland0.80583297
130MP0001915_intracranial_hemorrhage0.80306152
131MP0000313_abnormal_cell_death0.80184785
132MP0004087_abnormal_muscle_fiber0.80153233
133MP0001544_abnormal_cardiovascular_syste0.79600196
134MP0005385_cardiovascular_system_phenoty0.79600196
135MP0001661_extended_life_span0.78709189
136MP0003567_abnormal_fetal_cardiomyocyte0.78291993
137MP0005330_cardiomyopathy0.78255476
138MP0003699_abnormal_female_reproductive0.77578112
139MP0002234_abnormal_pharynx_morphology0.77457166
140MP0002405_respiratory_system_inflammati0.77442084
141MP0009672_abnormal_birth_weight0.77396948
142MP0002075_abnormal_coat/hair_pigmentati0.77215972
143MP0002127_abnormal_cardiovascular_syste0.76996837
144MP0002138_abnormal_hepatobiliary_system0.76230682
145MP0005384_cellular_phenotype0.76032988
146MP0005023_abnormal_wound_healing0.75139265
147MP0004215_abnormal_myocardial_fiber0.75027610
148MP0000490_abnormal_crypts_of0.74891888
149MP0005174_abnormal_tail_pigmentation0.73355077
150MP0008932_abnormal_embryonic_tissue0.73185010
151MP0005220_abnormal_exocrine_pancreas0.70781841
152MP0005085_abnormal_gallbladder_physiolo0.70500229
153MP0001929_abnormal_gametogenesis0.69143606
154MP0002128_abnormal_blood_circulation0.68785356

Predicted human phenotypes

RankGene SetZ-score
1Fair hair (HP:0002286)4.26339398
2Abnormality of the fingertips (HP:0001211)4.15197007
3Thyroid carcinoma (HP:0002890)3.79065889
4T lymphocytopenia (HP:0005403)3.30670044
5Recurrent viral infections (HP:0004429)3.10473797
6Volvulus (HP:0002580)3.09622439
7Abnormality of T cell number (HP:0011839)3.00283810
8Bundle branch block (HP:0011710)2.99434004
9Generalized hypopigmentation of hair (HP:0011358)2.93524459
10Anhidrosis (HP:0000970)2.92630522
11Pheochromocytoma (HP:0002666)2.90461094
12Chromsome breakage (HP:0040012)2.82986669
13Panhypogammaglobulinemia (HP:0003139)2.82636907
14Prominent nose (HP:0000448)2.82341582
15Renal cortical cysts (HP:0000803)2.81546631
16Recurrent bronchitis (HP:0002837)2.78535207
17Hyperkalemia (HP:0002153)2.75765721
18Narrow palate (HP:0000189)2.75715066
19Tubulointerstitial nephritis (HP:0001970)2.73817882
20Thrombocytosis (HP:0001894)2.70833683
21Macroorchidism (HP:0000053)2.69574183
22Right ventricular cardiomyopathy (HP:0011663)2.66916343
23High pitched voice (HP:0001620)2.64021574
24Ankyloglossia (HP:0010296)2.63163723
25Ependymoma (HP:0002888)2.61889560
26Cerebral aneurysm (HP:0004944)2.57257195
27Subacute progressive viral hepatitis (HP:0006572)2.57054522
28Neuroendocrine neoplasm (HP:0100634)2.55791497
29Hypoplasia of the thymus (HP:0000778)2.54137677
30Dry hair (HP:0011359)2.52354438
31Aortic dissection (HP:0002647)2.49470988
32Short tibia (HP:0005736)2.48843667
33Coarse hair (HP:0002208)2.48108164
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.44288099
35Abnormality of T cells (HP:0002843)2.43774609
36Intrahepatic cholestasis (HP:0001406)2.42875845
37Chronic otitis media (HP:0000389)2.42491399
38Cholecystitis (HP:0001082)2.37483082
39Abnormal gallbladder physiology (HP:0012438)2.37483082
40Short 4th metacarpal (HP:0010044)2.36511187
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36511187
42Complete atrioventricular canal defect (HP:0001674)2.36493945
43Long eyelashes (HP:0000527)2.34916301
44Arterial tortuosity (HP:0005116)2.33739734
45Thyroiditis (HP:0100646)2.31364157
46Heterotopia (HP:0002282)2.30652922
47Poikiloderma (HP:0001029)2.30538560
48IgM deficiency (HP:0002850)2.30503555
49Bicuspid aortic valve (HP:0001647)2.29428784
50Chronic diarrhea (HP:0002028)2.27457762
51Astrocytoma (HP:0009592)2.24833847
52Abnormality of the astrocytes (HP:0100707)2.24833847
53Proximal tubulopathy (HP:0000114)2.23580283
54Abnormality of B cell number (HP:0010975)2.22996903
55B lymphocytopenia (HP:0010976)2.22996903
56Recurrent fungal infections (HP:0002841)2.22597130
57Flat acetabular roof (HP:0003180)2.22178724
58Hand muscle atrophy (HP:0009130)2.21681458
59Polycythemia (HP:0001901)2.21645985
60Neoplasm of the small intestine (HP:0100833)2.20192600
61Abnormality of secondary sexual hair (HP:0009888)2.19370149
62Abnormality of the axillary hair (HP:0100134)2.19370149
63Aortic aneurysm (HP:0004942)2.19221857
64Abnormality of the lower motor neuron (HP:0002366)2.19003326
65Amaurosis fugax (HP:0100576)2.17473375
66Lip pit (HP:0100267)2.15694162
67Agammaglobulinemia (HP:0004432)2.14799402
68Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.14017077
69Acanthocytosis (HP:0001927)2.13548658
70Colon cancer (HP:0003003)2.13489815
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.12920440
72Cubitus valgus (HP:0002967)2.12766029
73Palpitations (HP:0001962)2.11986512
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11702165
75Cutis marmorata (HP:0000965)2.09845215
76Metaphyseal dysplasia (HP:0100255)2.09290419
77Truncal obesity (HP:0001956)2.08993266
78Viral hepatitis (HP:0006562)2.07687278
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07396842
80Vascular tortuosity (HP:0004948)2.06790765
81Abnormality of methionine metabolism (HP:0010901)2.06361665
82Autoamputation (HP:0001218)2.04570029
83Broad palm (HP:0001169)2.03246293
84Abnormality of the left ventricular outflow tract (HP:0011103)2.02512992
85Subaortic stenosis (HP:0001682)2.02512992
86* Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01651317
87* Abnormal protein N-linked glycosylation (HP:0012347)2.01651317
88* Abnormal protein glycosylation (HP:0012346)2.01651317
89* Abnormal glycosylation (HP:0012345)2.01651317
90Hematochezia (HP:0002573)2.01201746
91Severe combined immunodeficiency (HP:0004430)1.99542641
92Overgrowth (HP:0001548)1.97752053
93Dysmetric saccades (HP:0000641)1.97505726
94Overlapping toe (HP:0001845)1.95601860
95Cutaneous melanoma (HP:0012056)1.94620237
96Trigonocephaly (HP:0000243)1.93797078
97Acute hepatic failure (HP:0006554)1.93508149
98Gastrointestinal carcinoma (HP:0002672)1.93347033
99Malignant gastrointestinal tract tumors (HP:0006749)1.93347033
100Pancreatic islet-cell hyperplasia (HP:0004510)1.93328726
101Entropion (HP:0000621)1.92965843
102Glioma (HP:0009733)1.92736031
103Urethral obstruction (HP:0000796)1.92610004
104Abnormal biliary tract morphology (HP:0012440)1.91088371
105Vertebral arch anomaly (HP:0008438)1.90649985
106Absent frontal sinuses (HP:0002688)1.90579023
107IgA deficiency (HP:0002720)1.90498464
108Ridged nail (HP:0001807)1.90166769
109Curly hair (HP:0002212)1.89642413
110Long clavicles (HP:0000890)1.88954897
111Combined immunodeficiency (HP:0005387)1.88328488
112Gastrointestinal inflammation (HP:0004386)1.87906443
113Abnormality of the prostate (HP:0008775)1.87685392
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87429416
115Sandal gap (HP:0001852)1.86722496
116Arterial thrombosis (HP:0004420)1.85677704
117Dilatation of the ascending aorta (HP:0005111)1.85393228
118Chest pain (HP:0100749)1.84842351
119Acute myeloid leukemia (HP:0004808)1.84343946
120Abnormality of the epiphyses of the hand (HP:0005924)1.84295980
121Aneurysm (HP:0002617)1.84189597
122Basal cell carcinoma (HP:0002671)1.82367757
123Inflammation of the large intestine (HP:0002037)1.81692185
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81514398
125Hypoplastic iliac wings (HP:0002866)1.80546766
126Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.80113244
127Large earlobe (HP:0009748)1.78936064
128Hypoplasia of the iris (HP:0007676)1.76994443
129Increased density of long bones (HP:0006392)1.76905310
130Sensorimotor neuropathy (HP:0007141)1.76850869
131Deep philtrum (HP:0002002)1.76162619
132Lymphopenia (HP:0001888)1.76138534
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75848574
134Transitional cell carcinoma of the bladder (HP:0006740)1.75318623
135Abnormality of the labia majora (HP:0012881)1.75081137
136Abnormal auditory evoked potentials (HP:0006958)1.74883250
137Breech presentation (HP:0001623)1.74324128
138Verrucae (HP:0200043)1.73570958
139Papilloma (HP:0012740)1.73570958
140Colitis (HP:0002583)1.73102404
141Exercise-induced muscle cramps (HP:0003710)1.73034041
142Papillary thyroid carcinoma (HP:0002895)1.72979734
143Anterior segment dysgenesis (HP:0007700)1.72106486
144Abnormality of chromosome stability (HP:0003220)1.71521899
145Spontaneous hematomas (HP:0007420)1.70943349
146Cervical subluxation (HP:0003308)1.70701942
147Striae distensae (HP:0001065)1.70344761
148Medulloblastoma (HP:0002885)1.69964625
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.69351030
150Poor coordination (HP:0002370)1.69114330
151Low anterior hairline (HP:0000294)1.68561921
152Congenital primary aphakia (HP:0007707)1.68478947
153Thickened calvaria (HP:0002684)1.68465002
154Cranial hyperostosis (HP:0004437)1.68112373
155Cystic hygroma (HP:0000476)1.67577295
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67502477
157Pseudobulbar signs (HP:0002200)1.66811409
158Facial hemangioma (HP:0000329)1.66287817
159Biliary tract neoplasm (HP:0100574)1.64881459
160Cellulitis (HP:0100658)1.64243068
161Hypoplastic labia majora (HP:0000059)1.63626624
162Abnormality of the pancreatic islet cells (HP:0006476)1.63482696
163Abnormality of endocrine pancreas physiology (HP:0012093)1.63482696
164Upper limb amyotrophy (HP:0009129)1.62754626
165Distal upper limb amyotrophy (HP:0007149)1.62754626
166Fatigue (HP:0012378)1.62426110
167Lower limb hyperreflexia (HP:0002395)1.62408240
168Brushfield spots (HP:0001088)1.61863391
169Abnormality of the 4th metacarpal (HP:0010012)1.61683238
170Hyporeflexia of lower limbs (HP:0002600)1.61271997
171Periodontitis (HP:0000704)1.61169042
172Hepatocellular carcinoma (HP:0001402)1.60639944
173Lymphoma (HP:0002665)1.60594959
174Abnormality of oral frenula (HP:0000190)1.59929353
175Neoplasm of the rectum (HP:0100743)1.59785623
176Leiomyosarcoma (HP:0100243)1.59101296
177Uterine leiomyosarcoma (HP:0002891)1.59101296
178Abnormality of homocysteine metabolism (HP:0010919)1.58525266
179Homocystinuria (HP:0002156)1.58525266
180Abnormality of the renal cortex (HP:0011035)1.58348287
181Increased circulating renin level (HP:0000848)1.57853804
182Thickened nuchal skin fold (HP:0000474)1.57748275
183Cafe-au-lait spot (HP:0000957)1.56050263
184Obsessive-compulsive behavior (HP:0000722)1.55928765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.66910703
2EIF2AK33.10021491
3MAP4K12.99089452
4PKN22.90322532
5MAP3K102.83065865
6MET2.67206598
7BMPR22.66722155
8CAMK1D2.51581785
9CDK122.29130057
10CDC72.21274843
11EIF2AK12.19185640
12TIE12.15258548
13BRSK22.09785159
14BRD42.08717341
15AKT32.03809278
16FLT31.90808466
17JAK31.86644237
18SCYL21.85013927
19TTN1.83738913
20ITK1.83001993
21CAMK1G1.82782258
22FGFR31.79957123
23FGFR41.78462696
24OBSCN1.73596300
25TGFBR11.72678717
26NEK21.68681030
27PASK1.64589274
28TRPM71.64325884
29BCR1.56930510
30ERBB31.55567883
31PIK3CG1.55361337
32TEC1.51737343
33NEK61.49950328
34TYK21.49292104
35TTK1.47857575
36PDK21.47784596
37LRRK21.46888833
38TXK1.46748361
39SRPK11.46364746
40MAP3K21.45475409
41ZAP701.44713553
42JAK11.44280491
43KSR21.36374442
44TRIB31.36023457
45FER1.34464987
46CAMKK21.30561489
47PDGFRA1.25784011
48CSF1R1.25588536
49STK101.25474891
50PTK61.25154426
51ATR1.23964466
52FRK1.22225618
53TSSK61.21366645
54LMTK21.20428992
55EPHB11.19088176
56NLK1.18030637
57RIPK11.17219407
58MYLK1.14915330
59FGFR21.14498120
60FGFR11.10264048
61RPS6KB21.09872305
62MST1R1.09401894
63MAP3K141.07899509
64SIK11.07765188
65TNIK1.06339161
66MST41.02045656
67PRKD31.01852779
68MTOR1.01540797
69GRK61.01074010
70CDK61.00855505
71PBK0.99288361
72MAP3K40.98641896
73CDK40.97843462
74WNK10.95731743
75RIPK40.92719217
76PDK40.92616477
77PDK30.92616477
78LATS10.92611546
79STK390.91710385
80ZAK0.91602641
81ACVR1B0.88997771
82MOS0.87156503
83YES10.86202998
84SGK30.85429582
85SYK0.84712895
86CHEK10.84257032
87BTK0.81920259
88NUAK10.79610227
89HCK0.77683157
90ATM0.76502295
91TGFBR20.76405711
92PRKCH0.76382918
93PRKAA10.74880564
94PDGFRB0.73309642
95EIF2AK20.71903442
96DMPK0.70675091
97RET0.68773582
98KIT0.68194853
99KSR10.67806420
100RAF10.67212256
101CHUK0.66886341
102LCK0.66825755
103PIK3CA0.66663544
104STK40.65884695
105ALK0.65071081
106MAP3K70.63607936
107CSNK1A1L0.63557987
108PLK20.63441675
109RPS6KA40.63429973
110MAP2K10.62491280
111KDR0.59121602
112STK240.58575934
113TAOK30.57800235
114NEK10.57789678
115MAPK110.55723663
116RPS6KB10.55028449
117STK380.52573073
118MAPKAPK30.52251355
119AURKB0.51475974
120MELK0.50310614
121SGK20.49770989
122CDK20.48813114
123EPHA30.47975461
124STK30.47175942
125TRIM280.47146658
126EGFR0.47043206
127JAK20.46520847
128CLK10.45745395
129INSRR0.45377822
130PRKAA20.44897177
131IRAK10.44799335
132BMX0.44551602
133DYRK1B0.44411390
134PIM10.44202870
135MAP3K80.43962262
136PRKDC0.43034174
137HIPK20.42681252
138MAP3K50.42468702
139PRKCQ0.42391767
140PTK20.41678064
141CSK0.41601922
142NEK90.41194650
143ICK0.41078523
144MAP3K130.38578852
145CDK90.38293687
146CHEK20.37439864
147CSNK1G10.33652630
148MAPK100.30940469
149ROCK10.29526098
150PRKCE0.29116211

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.88723542
2Primary immunodeficiency_Homo sapiens_hsa053402.73991289
3Propanoate metabolism_Homo sapiens_hsa006402.12905090
4Thyroid cancer_Homo sapiens_hsa052161.92677674
5B cell receptor signaling pathway_Homo sapiens_hsa046621.84598949
6Antigen processing and presentation_Homo sapiens_hsa046121.78649936
7Systemic lupus erythematosus_Homo sapiens_hsa053221.77472260
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76686559
9T cell receptor signaling pathway_Homo sapiens_hsa046601.67257136
10Lysine degradation_Homo sapiens_hsa003101.60374104
11Non-homologous end-joining_Homo sapiens_hsa034501.59750847
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58765994
13Viral carcinogenesis_Homo sapiens_hsa052031.53033214
14mTOR signaling pathway_Homo sapiens_hsa041501.44031503
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43969466
16Viral myocarditis_Homo sapiens_hsa054161.42924692
17Basal transcription factors_Homo sapiens_hsa030221.41828961
18Cell cycle_Homo sapiens_hsa041101.41136497
19Chronic myeloid leukemia_Homo sapiens_hsa052201.35682430
20Steroid biosynthesis_Homo sapiens_hsa001001.31702613
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31593929
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.31107428
23Prostate cancer_Homo sapiens_hsa052151.29701706
24Measles_Homo sapiens_hsa051621.28881757
25Insulin resistance_Homo sapiens_hsa049311.23416768
26Dorso-ventral axis formation_Homo sapiens_hsa043201.22167545
27Colorectal cancer_Homo sapiens_hsa052101.20861314
28Renal cell carcinoma_Homo sapiens_hsa052111.20301626
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19853679
30One carbon pool by folate_Homo sapiens_hsa006701.18641831
31Glucagon signaling pathway_Homo sapiens_hsa049221.18506724
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18498623
33HTLV-I infection_Homo sapiens_hsa051661.18438337
34Dilated cardiomyopathy_Homo sapiens_hsa054141.17004711
35Non-small cell lung cancer_Homo sapiens_hsa052231.16215616
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14970941
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12640401
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12622072
39Mismatch repair_Homo sapiens_hsa034301.10681951
40DNA replication_Homo sapiens_hsa030301.09262673
41Type II diabetes mellitus_Homo sapiens_hsa049301.08782881
42Base excision repair_Homo sapiens_hsa034101.08242627
43Selenocompound metabolism_Homo sapiens_hsa004501.06911926
44RNA transport_Homo sapiens_hsa030131.06502654
45ECM-receptor interaction_Homo sapiens_hsa045121.05992350
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05691934
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05362529
48MicroRNAs in cancer_Homo sapiens_hsa052061.05304601
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04892338
50mRNA surveillance pathway_Homo sapiens_hsa030151.04850617
51Small cell lung cancer_Homo sapiens_hsa052221.04692518
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04563546
53Osteoclast differentiation_Homo sapiens_hsa043801.03120201
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.02913972
55Nitrogen metabolism_Homo sapiens_hsa009101.02577065
56Adherens junction_Homo sapiens_hsa045201.02151889
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00213604
58Hepatitis B_Homo sapiens_hsa051610.99925083
59Platelet activation_Homo sapiens_hsa046110.99618934
60Fanconi anemia pathway_Homo sapiens_hsa034600.99013045
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98681597
62Pancreatic cancer_Homo sapiens_hsa052120.98403725
63Herpes simplex infection_Homo sapiens_hsa051680.97514451
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96528593
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95808298
66Nucleotide excision repair_Homo sapiens_hsa034200.95624879
67RNA degradation_Homo sapiens_hsa030180.94554982
68Toxoplasmosis_Homo sapiens_hsa051450.94549470
69Alcoholism_Homo sapiens_hsa050340.94506980
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94461928
71ErbB signaling pathway_Homo sapiens_hsa040120.91749538
72Oocyte meiosis_Homo sapiens_hsa041140.91540971
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91529686
74HIF-1 signaling pathway_Homo sapiens_hsa040660.91423530
75Protein export_Homo sapiens_hsa030600.90995756
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90099840
77AMPK signaling pathway_Homo sapiens_hsa041520.89201387
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88309020
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88300959
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.87996203
81Insulin signaling pathway_Homo sapiens_hsa049100.86435958
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.85032361
83Pyruvate metabolism_Homo sapiens_hsa006200.84712386
84Fructose and mannose metabolism_Homo sapiens_hsa000510.83513070
85Acute myeloid leukemia_Homo sapiens_hsa052210.81726055
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.81606020
87Endometrial cancer_Homo sapiens_hsa052130.81444181
88Regulation of autophagy_Homo sapiens_hsa041400.81325413
89Prolactin signaling pathway_Homo sapiens_hsa049170.80755527
90Proteoglycans in cancer_Homo sapiens_hsa052050.79419760
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79372184
92Apoptosis_Homo sapiens_hsa042100.78818280
93Peroxisome_Homo sapiens_hsa041460.78377454
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.76444152
95TGF-beta signaling pathway_Homo sapiens_hsa043500.75762270
96Influenza A_Homo sapiens_hsa051640.75447215
97Estrogen signaling pathway_Homo sapiens_hsa049150.74359399
98p53 signaling pathway_Homo sapiens_hsa041150.72853488
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72769502
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72494345
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71518707
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.71475290
103Epstein-Barr virus infection_Homo sapiens_hsa051690.70924601
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70821520
105ABC transporters_Homo sapiens_hsa020100.70206764
106Biosynthesis of amino acids_Homo sapiens_hsa012300.70110348
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70025810
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69498411
109Spliceosome_Homo sapiens_hsa030400.69298105
110Legionellosis_Homo sapiens_hsa051340.69107448
111Homologous recombination_Homo sapiens_hsa034400.68968868
112Inositol phosphate metabolism_Homo sapiens_hsa005620.68098833
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66987748
114Focal adhesion_Homo sapiens_hsa045100.66456311
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66116486
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65549884
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63757633
118Notch signaling pathway_Homo sapiens_hsa043300.63620208
119Leishmaniasis_Homo sapiens_hsa051400.63498165
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.63444465
121VEGF signaling pathway_Homo sapiens_hsa043700.63268415
122Fatty acid metabolism_Homo sapiens_hsa012120.62944555
123N-Glycan biosynthesis_Homo sapiens_hsa005100.62755171
124Glioma_Homo sapiens_hsa052140.60647137
125TNF signaling pathway_Homo sapiens_hsa046680.60584043
126FoxO signaling pathway_Homo sapiens_hsa040680.59827703
127Hematopoietic cell lineage_Homo sapiens_hsa046400.59179666
128Shigellosis_Homo sapiens_hsa051310.58655642
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58466506
130Fatty acid elongation_Homo sapiens_hsa000620.58264765
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57982871
132Renin-angiotensin system_Homo sapiens_hsa046140.57417195
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56457542
134Protein digestion and absorption_Homo sapiens_hsa049740.56082376
135Renin secretion_Homo sapiens_hsa049240.55168063
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54960121
137Oxytocin signaling pathway_Homo sapiens_hsa049210.54302421
138Long-term potentiation_Homo sapiens_hsa047200.53285496
139Pentose phosphate pathway_Homo sapiens_hsa000300.53055888
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52467023
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.49783313
142Choline metabolism in cancer_Homo sapiens_hsa052310.49410267
143Sphingolipid metabolism_Homo sapiens_hsa006000.47743185
144Carbon metabolism_Homo sapiens_hsa012000.46660187
145Arginine biosynthesis_Homo sapiens_hsa002200.45862961

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