COG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.05976693
2COPI coating of Golgi vesicle (GO:0048205)7.05976693
3peptidyl-arginine omega-N-methylation (GO:0035247)5.68489227
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.38112217
5L-phenylalanine catabolic process (GO:0006559)5.38112217
6L-phenylalanine metabolic process (GO:0006558)5.25179345
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.25179345
8alpha-linolenic acid metabolic process (GO:0036109)5.01026911
9lysine metabolic process (GO:0006553)4.97634764
10lysine catabolic process (GO:0006554)4.97634764
11* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.85721287
12peptidyl-arginine N-methylation (GO:0035246)4.65732005
13peptidyl-arginine methylation (GO:0018216)4.65732005
14glyoxylate metabolic process (GO:0046487)4.60264820
15aromatic amino acid family catabolic process (GO:0009074)4.59265601
16amyloid precursor protein catabolic process (GO:0042987)4.52837110
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.52559563
18valine metabolic process (GO:0006573)4.51414836
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.48805379
20urea metabolic process (GO:0019627)4.41173619
21urea cycle (GO:0000050)4.41173619
22kynurenine metabolic process (GO:0070189)4.36760320
232-oxoglutarate metabolic process (GO:0006103)4.33057670
24pentose-phosphate shunt (GO:0006098)4.28702644
25acetyl-CoA metabolic process (GO:0006084)4.27530176
26serine family amino acid catabolic process (GO:0009071)4.26791650
27histone arginine methylation (GO:0034969)4.25640306
28NADPH regeneration (GO:0006740)4.23149919
29cysteine metabolic process (GO:0006534)4.19883241
30fatty acid beta-oxidation (GO:0006635)4.18217873
31fatty acid transmembrane transport (GO:1902001)4.16814691
32sulfur amino acid catabolic process (GO:0000098)4.15427090
33branched-chain amino acid catabolic process (GO:0009083)4.12625487
34amino-acid betaine metabolic process (GO:0006577)4.11657957
35aspartate family amino acid catabolic process (GO:0009068)4.09527396
36glycine metabolic process (GO:0006544)4.05667351
37bile acid biosynthetic process (GO:0006699)4.04804748
38tricarboxylic acid cycle (GO:0006099)4.04154083
39nitrogen cycle metabolic process (GO:0071941)4.03879179
404-hydroxyproline metabolic process (GO:0019471)4.01842320
41complement activation, alternative pathway (GO:0006957)4.01767625
42biotin metabolic process (GO:0006768)3.97821875
43negative regulation of fibrinolysis (GO:0051918)3.97445858
44indolalkylamine catabolic process (GO:0046218)3.95284692
45tryptophan catabolic process (GO:0006569)3.95284692
46indole-containing compound catabolic process (GO:0042436)3.95284692
47regulation of triglyceride catabolic process (GO:0010896)3.91522667
48homocysteine metabolic process (GO:0050667)3.91355405
49carnitine shuttle (GO:0006853)3.89364144
50fatty acid oxidation (GO:0019395)3.86313063
51regulation of protein activation cascade (GO:2000257)3.85214729
52regulation of sequestering of triglyceride (GO:0010889)3.84232897
53branched-chain amino acid metabolic process (GO:0009081)3.80717991
54oxaloacetate metabolic process (GO:0006107)3.79925422
55plasma lipoprotein particle clearance (GO:0034381)3.79691996
56fatty acid catabolic process (GO:0009062)3.78310723
57tryptophan metabolic process (GO:0006568)3.77073600
58alpha-amino acid catabolic process (GO:1901606)3.76936950
59lipid oxidation (GO:0034440)3.75959101
60synaptonemal complex assembly (GO:0007130)3.74459921
61low-density lipoprotein particle clearance (GO:0034383)3.72867893
62protein retention in ER lumen (GO:0006621)3.72216663
63serine family amino acid metabolic process (GO:0009069)3.72142023
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.70855206
65cellular ketone body metabolic process (GO:0046950)3.69882341
66peptidyl-glutamic acid carboxylation (GO:0017187)3.69503895
67protein carboxylation (GO:0018214)3.69503895
68regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.68134609
69regulation of complement activation (GO:0030449)3.67412716
70regulation of translational fidelity (GO:0006450)3.66935896
71serine family amino acid biosynthetic process (GO:0009070)3.64869350
72positive regulation of fatty acid beta-oxidation (GO:0032000)3.61859647
73positive regulation of receptor biosynthetic process (GO:0010870)3.58388849
74regulation of cholesterol biosynthetic process (GO:0045540)3.58327399
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56714106
76bile acid metabolic process (GO:0008206)3.55262767
77acylglycerol homeostasis (GO:0055090)3.54968623
78triglyceride homeostasis (GO:0070328)3.54968623
79cellular amino acid catabolic process (GO:0009063)3.54820132
80carnitine metabolic process (GO:0009437)3.51617741
81negative regulation of fatty acid biosynthetic process (GO:0045717)3.50756453
82proline biosynthetic process (GO:0006561)3.49602095
83regulation of fibrinolysis (GO:0051917)3.48137901
84positive regulation of fatty acid oxidation (GO:0046321)3.47952237
85tyrosine metabolic process (GO:0006570)3.47855485
86regulation of fatty acid beta-oxidation (GO:0031998)3.45241860
87NADH metabolic process (GO:0006734)3.45146525
88monocarboxylic acid catabolic process (GO:0072329)3.45132953
89glucose catabolic process (GO:0006007)3.45079475
90aromatic amino acid family metabolic process (GO:0009072)3.44670442
91high-density lipoprotein particle remodeling (GO:0034375)3.43721675
92fatty acid homeostasis (GO:0055089)3.41219806
93tricarboxylic acid metabolic process (GO:0072350)3.41109328
94amyloid precursor protein metabolic process (GO:0042982)3.39488667
95peptidyl-arginine modification (GO:0018195)3.39295593
96ethanol oxidation (GO:0006069)3.35954112
97negative regulation of cell size (GO:0045792)3.35453429
98glycolytic process (GO:0006096)3.35217235
99regulation of fatty acid oxidation (GO:0046320)3.34929027
100carboxylic acid catabolic process (GO:0046395)3.34691992
101organic acid catabolic process (GO:0016054)3.34691992
102coenzyme catabolic process (GO:0009109)3.33764595
103short-chain fatty acid metabolic process (GO:0046459)3.30669121
104ketone body metabolic process (GO:1902224)3.25006494
105vesicle coating (GO:0006901)3.24342876
106gluconeogenesis (GO:0006094)3.23672455
107mitochondrial fusion (GO:0008053)3.22804203
108triglyceride catabolic process (GO:0019433)3.18763392
109carnitine transmembrane transport (GO:1902603)3.18588977
110positive regulation of lipid catabolic process (GO:0050996)3.18094435
111amino-acid betaine transport (GO:0015838)3.15024681
112carnitine transport (GO:0015879)3.15024681
113monosaccharide biosynthetic process (GO:0046364)3.14584198
114L-serine metabolic process (GO:0006563)3.14226648
115acyl-CoA biosynthetic process (GO:0071616)3.11826698
116thioester biosynthetic process (GO:0035384)3.11826698
117regulation of mammary gland epithelial cell proliferation (GO:0033599)3.11048554
118epoxygenase P450 pathway (GO:0019373)3.10819781
119arginine metabolic process (GO:0006525)3.07844906
120UV protection (GO:0009650)3.07689125
121hexose biosynthetic process (GO:0019319)3.07511957
122COPII vesicle coating (GO:0048208)3.06522725
123neutral lipid catabolic process (GO:0046461)3.05392056
124acylglycerol catabolic process (GO:0046464)3.05392056
125chromosome organization involved in meiosis (GO:0070192)3.05162151
126dicarboxylic acid biosynthetic process (GO:0043650)3.02266037
127positive regulation of lipoprotein lipase activity (GO:0051006)3.01102281
128positive regulation of triglyceride lipase activity (GO:0061365)3.01102281
129phospholipid homeostasis (GO:0055091)3.00470876
130synaptonemal complex organization (GO:0070193)2.98256957
131regulation of cholesterol metabolic process (GO:0090181)2.98028544
132macromolecular complex remodeling (GO:0034367)2.97644012
133plasma lipoprotein particle remodeling (GO:0034369)2.97644012
134protein-lipid complex remodeling (GO:0034368)2.97644012
135acyl-CoA metabolic process (GO:0006637)2.97323627
136GDP-mannose metabolic process (GO:0019673)2.92429932
137positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.92101321
138L-serine transport (GO:0015825)2.90023165
139protein insertion into membrane (GO:0051205)2.88230854
140mitotic chromosome condensation (GO:0007076)2.87001956
141activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.84389850
142citrulline metabolic process (GO:0000052)2.82620150
143peptidyl-lysine dimethylation (GO:0018027)2.82229680
144protein maturation by protein folding (GO:0022417)2.81740914
145peptidyl-proline hydroxylation (GO:0019511)2.79158398
146DNA synthesis involved in DNA repair (GO:0000731)2.78677473
147glutamine family amino acid biosynthetic process (GO:0009084)2.78317964
148positive regulation of nuclease activity (GO:0032075)2.75193168
149NADP metabolic process (GO:0006739)2.74825387
150glycogen catabolic process (GO:0005980)2.68075757
151proline metabolic process (GO:0006560)2.67379503
152formation of translation preinitiation complex (GO:0001731)2.65148917
153mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63442287
154lens fiber cell development (GO:0070307)2.61234953
155protein hydroxylation (GO:0018126)2.58886212
156negative regulation of catenin import into nucleus (GO:0035414)2.58590151
157meiotic chromosome segregation (GO:0045132)2.57448324
158snRNA processing (GO:0016180)2.56670622
159virion assembly (GO:0019068)2.56248591
160spliceosomal tri-snRNP complex assembly (GO:0000244)2.55992561
161snRNA metabolic process (GO:0016073)2.55507707
162glucose 6-phosphate metabolic process (GO:0051156)2.53430421
163viral protein processing (GO:0019082)2.53057417
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51893189
165fructose metabolic process (GO:0006000)2.51609849
166positive regulation of mitochondrial fission (GO:0090141)2.48415956
167camera-type eye morphogenesis (GO:0048593)2.47544530
168intracellular estrogen receptor signaling pathway (GO:0030520)2.47428849
169histone H4 deacetylation (GO:0070933)2.45987567
170endoplasmic reticulum unfolded protein response (GO:0030968)2.45111963
171glucan catabolic process (GO:0009251)2.44319465
172synapsis (GO:0007129)2.43255913
173endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.42710525
174histone H3-K9 demethylation (GO:0033169)2.41589751
175regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.39505501
176serine transport (GO:0032329)2.37935997
177creatine metabolic process (GO:0006600)2.37768210
178cerebellar Purkinje cell layer development (GO:0021680)2.37706558
179meiosis I (GO:0007127)2.37179810
180regulation of nuclease activity (GO:0032069)2.36438721
181regulation of mitochondrial translation (GO:0070129)2.36263406
182iron-sulfur cluster assembly (GO:0016226)2.34409294
183metallo-sulfur cluster assembly (GO:0031163)2.34409294
184pyruvate metabolic process (GO:0006090)2.32278692
185basement membrane organization (GO:0071711)2.31988972
186establishment of mitochondrion localization (GO:0051654)2.31360995
187cellular polysaccharide catabolic process (GO:0044247)2.31224256
188cellular response to unfolded protein (GO:0034620)2.30416277
189macroautophagy (GO:0016236)2.29032990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.91792958
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.60515543
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.33400285
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.88549145
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.18876315
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.81199917
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.53695701
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.37043909
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98166654
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.74424727
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62543058
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62235042
13CLOCK_20551151_ChIP-Seq_293T_Human2.48901672
14E2F7_22180533_ChIP-Seq_HELA_Human2.39194474
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16494078
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11235849
17LXR_22292898_ChIP-Seq_THP-1_Human2.10417777
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.94650849
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.92825765
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89539412
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88968340
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86897454
23AR_21909140_ChIP-Seq_LNCAP_Human1.81270446
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80430136
25* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79216835
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.78208506
27RACK7_27058665_Chip-Seq_MCF-7_Human1.76230410
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.75160840
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72441544
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66193934
31* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61517274
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.61003378
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.60263168
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58811124
35VDR_21846776_ChIP-Seq_THP-1_Human1.52161772
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51796879
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49511122
38ZNF263_19887448_ChIP-Seq_K562_Human1.47787690
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43703944
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43220207
41SMC4_20622854_ChIP-Seq_HELA_Human1.42206060
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.40957847
43* YY1_21170310_ChIP-Seq_MESCs_Mouse1.39818450
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39337858
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39210231
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38277086
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36534075
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36503833
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35988799
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35849288
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35211023
52SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.34701234
53CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34142273
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33592075
55* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30551009
56* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29320138
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28150455
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27566020
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.26836854
60* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26755096
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24606124
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23698088
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22191537
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21208399
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20772421
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18995238
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18837466
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.18235074
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.18166644
70BCL6_27268052_Chip-Seq_Bcells_Human1.16615538
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.15889471
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15103441
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14343979
74PHF8_20622854_ChIP-Seq_HELA_Human1.14042174
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13611060
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13278598
77CIITA_25753668_ChIP-Seq_RAJI_Human1.12588287
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.12318129
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10791881
80* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.09809706
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09159036
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07775851
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07724467
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.07299995
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06972453
86GATA1_22025678_ChIP-Seq_K562_Human1.05950629
87TP53_22127205_ChIP-Seq_IMR90_Human1.05739699
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05036731
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04936257
90HNF4A_19822575_ChIP-Seq_HepG2_Human1.04570882
91* TTF2_22483619_ChIP-Seq_HELA_Human1.04569944
92MYC_22102868_ChIP-Seq_BL_Human1.03911101
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.03363793
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.02731467
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02631164
96* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02064297
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.00974342
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99155586
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97658604
100ATF3_27146783_Chip-Seq_COLON_Human0.95497548
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94353007
102RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93813263
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93492628
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93439538
105GABP_19822575_ChIP-Seq_HepG2_Human0.93140953
106DCP1A_22483619_ChIP-Seq_HELA_Human0.92821731
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92538153
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92030735
109* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91627332
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91581192
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91498149
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88909798
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87202165
114* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.85512706
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85486336
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83739332
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83455713
118RARA_24833708_ChIP-Seq_LIVER_Mouse0.82746691
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82561998
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82438680
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82360270
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81696352
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.80784950
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.80784950
125* XRN2_22483619_ChIP-Seq_HELA_Human0.80773453
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80096143
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78908714
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78173018
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77997390
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76563644
131THAP11_20581084_ChIP-Seq_MESCs_Mouse0.75903151
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75648861
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74867322
134KDM5A_27292631_Chip-Seq_BREAST_Human0.74160054
135RARB_24833708_ChIP-Seq_LIVER_Mouse0.73672994
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73558968
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73407297
138MYC_19079543_ChIP-ChIP_MESCs_Mouse0.72969748
139GABP_17652178_ChIP-ChIP_JURKAT_Human0.72429762
140GATA4_25053715_ChIP-Seq_YYC3_Human0.70311311
141* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.69766197
142BCOR_27268052_Chip-Seq_Bcells_Human0.68897238
143TFEB_21752829_ChIP-Seq_HELA_Human0.68571227
144P68_20966046_ChIP-Seq_HELA_Human0.67661582
145CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.67348265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.96552983
2MP0002139_abnormal_hepatobiliary_system5.58560696
3MP0003806_abnormal_nucleotide_metabolis4.98375757
4MP0005365_abnormal_bile_salt4.26707988
5MP0005085_abnormal_gallbladder_physiolo4.14077059
6MP0008260_abnormal_autophagy3.37736559
7MP0003705_abnormal_hypodermis_morpholog3.06106416
8MP0008875_abnormal_xenobiotic_pharmacok3.03217831
9MP0005058_abnormal_lysosome_morphology2.91263019
10MP0010329_abnormal_lipoprotein_level2.76153747
11MP0009840_abnormal_foam_cell2.70455296
12MP0003191_abnormal_cellular_cholesterol2.65693621
13MP0005670_abnormal_white_adipose2.63081061
14MP0010030_abnormal_orbit_morphology2.44809421
15MP0003252_abnormal_bile_duct2.42197302
16MP0008438_abnormal_cutaneous_collagen2.37639176
17MP0002837_dystrophic_cardiac_calcinosis2.29276540
18MP0005332_abnormal_amino_acid2.21895929
19MP0003111_abnormal_nucleus_morphology2.14011821
20MP0004858_abnormal_nervous_system2.06530185
21MP0003646_muscle_fatigue2.06477476
22MP0005083_abnormal_biliary_tract1.99890603
23MP0003950_abnormal_plasma_membrane1.98116529
24MP0000566_synostosis1.95042838
25MP0000537_abnormal_urethra_morphology1.90184946
26MP0004084_abnormal_cardiac_muscle1.86406153
27MP0004130_abnormal_muscle_cell1.86064592
28MP0005666_abnormal_adipose_tissue1.82553380
29MP0002118_abnormal_lipid_homeostasis1.80495352
30MP0001849_ear_inflammation1.78412922
31MP0000609_abnormal_liver_physiology1.76493396
32MP0003195_calcinosis1.72674113
33MP0008789_abnormal_olfactory_epithelium1.70593291
34MP0005248_abnormal_Harderian_gland1.59176254
35MP0001666_abnormal_nutrient_absorption1.58724494
36MP0006036_abnormal_mitochondrial_physio1.58599865
37MP0008007_abnormal_cellular_replicative1.58298125
38MP0001764_abnormal_homeostasis1.55998846
39MP0005319_abnormal_enzyme/_coenzyme1.55373903
40MP0004036_abnormal_muscle_relaxation1.54944871
41MP0003136_yellow_coat_color1.53355084
42MP0004782_abnormal_surfactant_physiolog1.52917001
43MP0003329_amyloid_beta_deposits1.51718735
44MP0008932_abnormal_embryonic_tissue1.50801470
45MP0005499_abnormal_olfactory_system1.50373312
46MP0005394_taste/olfaction_phenotype1.50373312
47MP0003786_premature_aging1.46719643
48MP0002269_muscular_atrophy1.42887045
49MP0004185_abnormal_adipocyte_glucose1.42114265
50MP0003693_abnormal_embryo_hatching1.37538752
51MP0003941_abnormal_skin_development1.36019169
52MP0001661_extended_life_span1.35029681
53MP0003942_abnormal_urinary_system1.33818035
54MP0003186_abnormal_redox_activity1.33810332
55MP0003115_abnormal_respiratory_system1.33588703
56MP0000751_myopathy1.33109563
57MP0004264_abnormal_extraembryonic_tissu1.32537447
58MP0005451_abnormal_body_composition1.32180659
59MP0008995_early_reproductive_senescence1.32093514
60MP0002971_abnormal_brown_adipose1.28022877
61MP0009053_abnormal_anal_canal1.27526410
62MP0009384_cardiac_valve_regurgitation1.27077226
63MP0005266_abnormal_metabolism1.26043053
64MP0000749_muscle_degeneration1.25189699
65MP0005501_abnormal_skin_physiology1.23578720
66MP0002877_abnormal_melanocyte_morpholog1.23057182
67MP0003077_abnormal_cell_cycle1.22669118
68MP0005584_abnormal_enzyme/coenzyme_acti1.22455822
69MP0003183_abnormal_peptide_metabolism1.21283949
70MP0010352_gastrointestinal_tract_polyps1.21225657
71MP0004087_abnormal_muscle_fiber1.20053918
72MP0001346_abnormal_lacrimal_gland1.19771714
73MP0002132_abnormal_respiratory_system1.19540995
74MP0005275_abnormal_skin_tensile1.18556675
75MP0002249_abnormal_larynx_morphology1.18002605
76MP0005375_adipose_tissue_phenotype1.17131368
77MP0005330_cardiomyopathy1.14686660
78MP0004233_abnormal_muscle_weight1.14593448
79MP0004019_abnormal_vitamin_homeostasis1.14123407
80MP0000733_abnormal_muscle_development1.11879503
81MP0006138_congestive_heart_failure1.11729886
82MP0009697_abnormal_copulation1.10122305
83MP0010368_abnormal_lymphatic_system1.09348197
84MP0005171_absent_coat_pigmentation1.09188873
85MP0000747_muscle_weakness1.08288341
86MP0005257_abnormal_intraocular_pressure1.07822331
87MP0003011_delayed_dark_adaptation1.06476709
88MP0003221_abnormal_cardiomyocyte_apopto1.06474728
89MP0002138_abnormal_hepatobiliary_system1.06105241
90MP0002332_abnormal_exercise_endurance1.05817914
91MP0009643_abnormal_urine_homeostasis1.05785896
92MP0000598_abnormal_liver_morphology1.04277179
93MP0002653_abnormal_ependyma_morphology1.03097062
94MP0003385_abnormal_body_wall1.02656891
95MP0003656_abnormal_erythrocyte_physiolo1.01084810
96MP0002080_prenatal_lethality1.00797421
97MP0008775_abnormal_heart_ventricle1.00190534
98MP0002210_abnormal_sex_determination0.97922433
99MP0002092_abnormal_eye_morphology0.97669342
100MP0002108_abnormal_muscle_morphology0.95008880
101MP0003566_abnormal_cell_adhesion0.94454720
102MP0002822_catalepsy0.92041526
103MP0005620_abnormal_muscle_contractility0.91938984
104MP0000750_abnormal_muscle_regeneration0.90310534
105MP0004197_abnormal_fetal_growth/weight/0.87559022
106MP0001529_abnormal_vocalization0.86614111
107MP0000858_altered_metastatic_potential0.86455421
108MP0005385_cardiovascular_system_phenoty0.86433897
109MP0001544_abnormal_cardiovascular_syste0.86433897
110MP0000467_abnormal_esophagus_morphology0.86319956
111MP0009672_abnormal_birth_weight0.85860180
112MP0000462_abnormal_digestive_system0.85486773
113MP0005023_abnormal_wound_healing0.85069848
114MP0005376_homeostasis/metabolism_phenot0.83428074
115MP0000003_abnormal_adipose_tissue0.83294510
116MP0003718_maternal_effect0.82638910
117MP0000759_abnormal_skeletal_muscle0.82517968
118MP0003984_embryonic_growth_retardation0.81857272
119MP0001270_distended_abdomen0.80979393
120MP0010630_abnormal_cardiac_muscle0.80904528
121MP0001730_embryonic_growth_arrest0.80136596
122MP0004215_abnormal_myocardial_fiber0.80086488
123MP0002089_abnormal_postnatal_growth/wei0.79646326
124MP0006035_abnormal_mitochondrial_morpho0.79476458
125MP0002084_abnormal_developmental_patter0.78577448
126MP0000762_abnormal_tongue_morphology0.78482266
127MP0002085_abnormal_embryonic_tissue0.78408921
128MP0009115_abnormal_fat_cell0.78173608
129MP0002078_abnormal_glucose_homeostasis0.77499697
130MP0001756_abnormal_urination0.76754897
131MP0005410_abnormal_fertilization0.76431309
132MP0003315_abnormal_perineum_morphology0.76287722
133MP0005408_hypopigmentation0.76011021
134MP0002697_abnormal_eye_size0.75677895
135MP0005409_darkened_coat_color0.75627312
136MP0002972_abnormal_cardiac_muscle0.75468379
137MP0005334_abnormal_fat_pad0.75179343
138MP0008058_abnormal_DNA_repair0.75053947
139MP0003938_abnormal_ear_development0.74898872
140MP0005380_embryogenesis_phenotype0.74888809
141MP0001672_abnormal_embryogenesis/_devel0.74888809
142MP0002970_abnormal_white_adipose0.74483158
143MP0001145_abnormal_male_reproductive0.73224714
144MP0004957_abnormal_blastocyst_morpholog0.73191883
145MP0002088_abnormal_embryonic_growth/wei0.73117097
146MP0004147_increased_porphyrin_level0.71460741
147MP0009763_increased_sensitivity_to0.70961449
148MP0002106_abnormal_muscle_physiology0.68561806
149MP0000013_abnormal_adipose_tissue0.64994213
150MP0009780_abnormal_chondrocyte_physiolo0.64981066
151MP0000358_abnormal_cell_content/0.64757531
152MP0005647_abnormal_sex_gland0.64495971
153MP0005395_other_phenotype0.64260374
154MP0004272_abnormal_basement_membrane0.61740027
155MP0010307_abnormal_tumor_latency0.61306842
156MP0004145_abnormal_muscle_electrophysio0.59601083
157MP0005636_abnormal_mineral_homeostasis0.57149389
158MP0000604_amyloidosis0.54384056
159MP0002060_abnormal_skin_morphology0.54070949
160MP0005369_muscle_phenotype0.53991317
161MP0009642_abnormal_blood_homeostasis0.52537562
162MP0003868_abnormal_feces_composition0.52517824
163MP0010094_abnormal_chromosome_stability0.52125021
164MP0010234_abnormal_vibrissa_follicle0.52059591

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.90599954
2Deep venous thrombosis (HP:0002625)4.79270047
3Hyperglycinuria (HP:0003108)4.67082033
4Hypobetalipoproteinemia (HP:0003563)4.66754954
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.43660248
6Xanthomatosis (HP:0000991)4.32000113
7Abnormality of serine family amino acid metabolism (HP:0010894)4.26974650
8Abnormality of glycine metabolism (HP:0010895)4.26974650
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.26588981
10Hyperammonemia (HP:0001987)4.23115815
11Hyperglycinemia (HP:0002154)4.16365144
12Abnormality of fatty-acid metabolism (HP:0004359)4.06740158
13Hypoglycemic coma (HP:0001325)4.01895561
14Hypolipoproteinemia (HP:0010981)3.96071087
15Ketosis (HP:0001946)3.95284577
16Myopathic facies (HP:0002058)3.94414752
17Myoglobinuria (HP:0002913)3.88580770
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.72600512
19Hypoalphalipoproteinemia (HP:0003233)3.70103407
20Short nail (HP:0001799)3.68466748
21Broad distal phalanx of finger (HP:0009836)3.60902111
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.50123977
23Hyperlipoproteinemia (HP:0010980)3.47389076
24Complement deficiency (HP:0004431)3.46668291
25Rhabdomyolysis (HP:0003201)3.31822186
26Ketoacidosis (HP:0001993)3.25255089
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20413682
28Dicarboxylic aciduria (HP:0003215)3.20413682
29Abnormality of pyrimidine metabolism (HP:0004353)3.14621084
30Epidermoid cyst (HP:0200040)3.12397708
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.10269009
32Prolonged partial thromboplastin time (HP:0003645)3.00485145
33Distal upper limb amyotrophy (HP:0007149)2.99768920
34Upper limb amyotrophy (HP:0009129)2.99768920
35Reticulocytosis (HP:0001923)2.98836457
36Exercise-induced myalgia (HP:0003738)2.98184396
37Exercise-induced muscle cramps (HP:0003710)2.97824103
38Increased serum pyruvate (HP:0003542)2.95596734
39Abnormality of glycolysis (HP:0004366)2.95596734
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.95369318
41Cholecystitis (HP:0001082)2.95322558
42Abnormal gallbladder physiology (HP:0012438)2.95322558
43Hyperacusis (HP:0010780)2.92329086
44Abnormality of serum amino acid levels (HP:0003112)2.87113379
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.86255899
46Flattened epiphyses (HP:0003071)2.84195023
47Hand muscle atrophy (HP:0009130)2.83311530
48Cholelithiasis (HP:0001081)2.76734261
49Abnormality of the intrinsic pathway (HP:0010989)2.75050952
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74881106
51Abnormality of nucleobase metabolism (HP:0010932)2.73554176
52Abnormal gallbladder morphology (HP:0012437)2.73253063
53Gout (HP:0001997)2.71532866
54Skin nodule (HP:0200036)2.70378444
55Hypercholesterolemia (HP:0003124)2.65398609
56Abnormality of methionine metabolism (HP:0010901)2.61954878
57Muscle fiber inclusion bodies (HP:0100299)2.61527070
58Abnormality of dentin (HP:0010299)2.59173582
59Nemaline bodies (HP:0003798)2.56928836
60Abnormality of the anterior horn cell (HP:0006802)2.56441024
61Degeneration of anterior horn cells (HP:0002398)2.56441024
62Microvesicular hepatic steatosis (HP:0001414)2.56249074
63Increased connective tissue (HP:0009025)2.53916884
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.53780116
65Abnormality of purine metabolism (HP:0004352)2.53020722
66Vertebral compression fractures (HP:0002953)2.52714541
67Abnormality of reticulocytes (HP:0004312)2.52670136
68Lethargy (HP:0001254)2.50899718
69Generalized aminoaciduria (HP:0002909)2.50880734
70Abnormality of the common coagulation pathway (HP:0010990)2.50366490
71Mildly elevated creatine phosphokinase (HP:0008180)2.49771516
72Spastic diplegia (HP:0001264)2.48656651
73Fat malabsorption (HP:0002630)2.48478201
74Spinal rigidity (HP:0003306)2.46380234
75Abnormality of complement system (HP:0005339)2.46030376
76Abnormality of the calcaneus (HP:0008364)2.45793443
77Distal lower limb muscle weakness (HP:0009053)2.44560945
78Rimmed vacuoles (HP:0003805)2.44207083
79Abnormal cartilage morphology (HP:0002763)2.41620697
80Cerebral edema (HP:0002181)2.41344676
81Premature rupture of membranes (HP:0001788)2.39679264
82Hyporeflexia of lower limbs (HP:0002600)2.39217677
83Brushfield spots (HP:0001088)2.37960974
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36134288
85Muscle fiber splitting (HP:0003555)2.35034520
86Metabolic acidosis (HP:0001942)2.34342729
87Distal lower limb amyotrophy (HP:0008944)2.34136063
88Entropion (HP:0000621)2.33674407
89Increased variability in muscle fiber diameter (HP:0003557)2.31002644
90Hyperbilirubinemia (HP:0002904)2.29823133
91Right ventricular cardiomyopathy (HP:0011663)2.28040638
92Increased purine levels (HP:0004368)2.25518428
93Hyperuricemia (HP:0002149)2.25518428
94Broad face (HP:0000283)2.22854317
95Abnormality of skeletal muscle fiber size (HP:0012084)2.22210536
96Difficulty climbing stairs (HP:0003551)2.21408168
97Hepatocellular carcinoma (HP:0001402)2.19966437
98Hypertriglyceridemia (HP:0002155)2.18783649
99Shoulder girdle muscle weakness (HP:0003547)2.17892127
100Nausea (HP:0002018)2.17327345
101Hydroxyprolinuria (HP:0003080)2.12809095
102Abnormality of proline metabolism (HP:0010907)2.12809095
103Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.10762925
104Absent epiphyses (HP:0010577)2.10762925
105Global brain atrophy (HP:0002283)2.09274167
106Multiple enchondromatosis (HP:0005701)2.09160676
107Abnormality of the gallbladder (HP:0005264)2.09151650
108Back pain (HP:0003418)2.08051773
109Hypoglycemic seizures (HP:0002173)2.06612923
110Ragged-red muscle fibers (HP:0003200)2.06543017
111Delayed CNS myelination (HP:0002188)2.06445120
112Oligomenorrhea (HP:0000876)2.04981038
113Proximal tubulopathy (HP:0000114)2.04636023
114Type 1 muscle fiber predominance (HP:0003803)2.04519917
115Hyperglycemia (HP:0003074)2.04342832
116Ulnar bowing (HP:0003031)2.03747713
11711 pairs of ribs (HP:0000878)2.00914504
118Protrusio acetabuli (HP:0003179)1.98793236
119Flat capital femoral epiphysis (HP:0003370)1.98637750
120Hepatic necrosis (HP:0002605)1.97197104
121Myocardial infarction (HP:0001658)1.96212271
122Acanthosis nigricans (HP:0000956)1.95978948
123Insulin resistance (HP:0000855)1.94877896
124J-shaped sella turcica (HP:0002680)1.94692784
125Cervical subluxation (HP:0003308)1.93928547
126Hypoplastic pelvis (HP:0008839)1.93905711
127Stridor (HP:0010307)1.93555891
128Scapular winging (HP:0003691)1.93283978
129Long palpebral fissure (HP:0000637)1.92518588
130Flat acetabular roof (HP:0003180)1.92360374
131Abnormality of the lower motor neuron (HP:0002366)1.91370762
132Muscle stiffness (HP:0003552)1.90253444
133Difficulty running (HP:0009046)1.89339092
134Vomiting (HP:0002013)1.88820036
135Palpitations (HP:0001962)1.85877786
136Round ear (HP:0100830)1.84751688
137Breech presentation (HP:0001623)1.84496351
138Limb-girdle muscle atrophy (HP:0003797)1.84017089
139Duplication of thumb phalanx (HP:0009942)1.83662622
140Partial duplication of thumb phalanx (HP:0009944)1.81515738
141Upper motor neuron abnormality (HP:0002127)1.81427685
142Calcaneovalgus deformity (HP:0001848)1.81321985
143Abnormality of the distal phalanges of the toes (HP:0010182)1.80959530
144Progressive muscle weakness (HP:0003323)1.80450488
145Steatorrhea (HP:0002570)1.78855302
146Increased muscle lipid content (HP:0009058)1.78144481
147Spontaneous abortion (HP:0005268)1.77814206
148Lipoatrophy (HP:0100578)1.76446061
149Biconcave vertebral bodies (HP:0004586)1.76354121
150Insomnia (HP:0100785)1.74189958
151Prolonged neonatal jaundice (HP:0006579)1.73146293
152Ankle contracture (HP:0006466)1.71668086
153Bulbar palsy (HP:0001283)1.71188312
154Hyperinsulinemic hypoglycemia (HP:0000825)1.70909953
155Asymmetric septal hypertrophy (HP:0001670)1.70827947
156EMG: neuropathic changes (HP:0003445)1.70254551
157Metaphyseal cupping (HP:0003021)1.69503328
158Cutaneous melanoma (HP:0012056)1.69474406
159Ventricular tachycardia (HP:0004756)1.69436066
160Sensorimotor neuropathy (HP:0007141)1.68916190
161Ulnar deviation of the wrist (HP:0003049)1.66661183
162Shallow orbits (HP:0000586)1.66428041
163Progressive external ophthalmoplegia (HP:0000590)1.65986018
164Mitral regurgitation (HP:0001653)1.65965326
165Bell-shaped thorax (HP:0001591)1.65428984
166Achilles tendon contracture (HP:0001771)1.64931681
167Thin ribs (HP:0000883)1.63246451
168Atelectasis (HP:0100750)1.61550559
169Metatarsus adductus (HP:0001840)1.61133040
170Cerebral aneurysm (HP:0004944)1.59606876
171Abnormality of pain sensation (HP:0010832)1.59252325
172Impaired pain sensation (HP:0007328)1.59252325
173Partial duplication of the phalanx of hand (HP:0009999)1.58736687
174Self-mutilation (HP:0000742)1.58617710
175Long toe (HP:0010511)1.56767401
176Hammertoe (HP:0001765)1.55846509
177Pointed chin (HP:0000307)1.55731825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.74852613
2PDK34.18518911
3PDK44.18518911
4NEK13.46125459
5TRIB33.20031682
6PKN22.68617328
7TTN2.55203454
8PDK22.47902886
9SIK12.21572559
10OBSCN2.01532733
11FGFR42.01091655
12FLT31.84278425
13MET1.73960238
14MAP2K31.72585898
15LATS11.69645729
16SMG11.61406566
17EPHA31.55982521
18ERN11.55659872
19DYRK1B1.50690125
20EPHB21.43857333
21MAP2K71.41353110
22NTRK11.38295171
23NEK91.38005147
24MAP3K61.37846725
25MUSK1.35497164
26LATS21.33669727
27EIF2AK11.30191509
28PRKD31.29259994
29CAMK1D1.24357072
30RIPK11.23449925
31PTK61.20654656
32MYLK1.17939069
33TESK11.17854672
34PIM21.17719159
35NEK21.17430291
36MAP2K41.17003386
37PRKD21.15453202
38CCNB11.14659351
39WEE11.14174741
40BMX1.09996744
41INSRR1.09681908
42NME21.08567843
43STK38L1.02596796
44BRSK11.02012170
45BUB10.98381356
46TTK0.97351997
47LMTK20.97013923
48EPHA20.96839800
49KSR20.96587967
50MAP2K20.96025480
51EPHB10.95578881
52MAP3K30.95471068
53FER0.94893583
54AURKA0.94225492
55TESK20.93142913
56TYRO30.90108616
57RET0.89723104
58TSSK60.84844692
59MAP3K80.82359341
60PHKG10.81748206
61PHKG20.81748206
62ERBB40.79064730
63PINK10.78457581
64SCYL20.76939506
65WNK40.76468241
66CDK70.76416915
67NEK60.75983277
68EEF2K0.73535190
69MAP2K10.73300466
70MAP2K60.72645441
71PRKAA10.72112127
72ZAK0.71044773
73TIE10.70798002
74KDR0.70401229
75MST1R0.70401031
76TAOK20.69632932
77LIMK10.69314831
78PIK3CG0.69303535
79BRSK20.68232461
80CDK40.67634631
81MAPKAPK30.66673561
82MAPK110.66117031
83PAK40.65880957
84PDGFRA0.65734177
85MAP3K40.64038086
86PLK10.63466382
87PRKAA20.63076576
88RPS6KA40.61594577
89PRPF4B0.60990825
90AKT30.60864156
91MAP3K110.60172457
92MTOR0.59495844
93CSF1R0.58979220
94ACVR1B0.58928020
95TGFBR10.58395263
96ZAP700.58119716
97KSR10.57939787
98LRRK20.57866533
99RPS6KA20.57628237
100PTK2B0.56772793
101MAP3K100.55722059
102FGFR10.55410175
103SIK30.54808330
104PTK20.53118629
105CDK11A0.52909996
106ATR0.52186134
107STK30.52114298
108MAP3K50.52100001
109PBK0.51830607
110CDK60.51263179
111TYK20.50400685
112ARAF0.47581162
113PAK30.47183719
114PASK0.46850193
115TRPM70.46476323
116PRKCI0.46072182
117CDK150.45955911
118CDK80.45879033
119BRAF0.44535457
120CDK180.43860900
121NME10.42875152
122CDK140.41611134
123FRK0.41150651
124IRAK30.41022608
125STK390.40484022
126RPS6KB10.39491638
127PDGFRB0.38545583
128PAK60.38437659
129CAMK2G0.38083422
130STK40.37918138
131JAK20.37840395
132MARK20.37305794
133DDR20.36993634
134SRPK10.36304149
135DAPK30.36189737
136PIK3CA0.35175476
137PDPK10.34803189
138CDK190.34061329
139CHEK10.33308808
140MAP3K70.32787799
141AURKB0.32761483
142CDC42BPA0.32224112
143FGFR20.31300986
144JAK10.30015351
145RPS6KB20.29835311
146MAP3K130.29721502
147AKT20.29464912
148ICK0.29217606
149PLK30.28375044

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32877781
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.14205586
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.09875479
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.08694812
5Propanoate metabolism_Homo sapiens_hsa006403.02119807
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.00204457
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.96753953
8Fatty acid degradation_Homo sapiens_hsa000712.86281594
9Arginine biosynthesis_Homo sapiens_hsa002202.55278206
10Pyruvate metabolism_Homo sapiens_hsa006202.34280988
11Carbon metabolism_Homo sapiens_hsa012002.32374948
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32300490
13Fatty acid metabolism_Homo sapiens_hsa012122.31225330
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29312578
15Nitrogen metabolism_Homo sapiens_hsa009102.26254727
16Tryptophan metabolism_Homo sapiens_hsa003802.26210713
17Other glycan degradation_Homo sapiens_hsa005112.25926308
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20459173
19Biosynthesis of amino acids_Homo sapiens_hsa012302.10510986
20PPAR signaling pathway_Homo sapiens_hsa033202.10080045
21Butanoate metabolism_Homo sapiens_hsa006502.02041607
22Peroxisome_Homo sapiens_hsa041461.97604189
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71279625
24Vitamin B6 metabolism_Homo sapiens_hsa007501.66409596
25Complement and coagulation cascades_Homo sapiens_hsa046101.65806125
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65736808
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63487732
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63076842
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.59495909
30Selenocompound metabolism_Homo sapiens_hsa004501.54676778
31beta-Alanine metabolism_Homo sapiens_hsa004101.53842333
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.52424556
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45320325
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44567870
35Pentose phosphate pathway_Homo sapiens_hsa000301.43819257
36Notch signaling pathway_Homo sapiens_hsa043301.43221674
37Fatty acid elongation_Homo sapiens_hsa000621.41825742
38N-Glycan biosynthesis_Homo sapiens_hsa005101.41373075
39Caffeine metabolism_Homo sapiens_hsa002321.34253215
40Phenylalanine metabolism_Homo sapiens_hsa003601.34234385
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32560924
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22112792
43Starch and sucrose metabolism_Homo sapiens_hsa005001.22022745
44Vibrio cholerae infection_Homo sapiens_hsa051101.19154424
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18953324
46Fat digestion and absorption_Homo sapiens_hsa049751.17135410
47Tyrosine metabolism_Homo sapiens_hsa003501.16799595
48Arginine and proline metabolism_Homo sapiens_hsa003301.11577596
49Chemical carcinogenesis_Homo sapiens_hsa052041.11258191
50One carbon pool by folate_Homo sapiens_hsa006701.11054992
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08410011
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05544544
53Retinol metabolism_Homo sapiens_hsa008301.05269990
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.05044788
55Histidine metabolism_Homo sapiens_hsa003401.04163113
56Glycerolipid metabolism_Homo sapiens_hsa005611.02725870
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97858754
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.91554786
59Folate biosynthesis_Homo sapiens_hsa007900.90910953
60Fatty acid biosynthesis_Homo sapiens_hsa000610.90744703
61Bile secretion_Homo sapiens_hsa049760.89007435
62Fructose and mannose metabolism_Homo sapiens_hsa000510.87751668
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.87597483
64Lysosome_Homo sapiens_hsa041420.84136251
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84064729
66Endometrial cancer_Homo sapiens_hsa052130.80558561
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78456874
68Staphylococcus aureus infection_Homo sapiens_hsa051500.78069431
69Lysine degradation_Homo sapiens_hsa003100.77434349
70Sulfur metabolism_Homo sapiens_hsa009200.75300691
71Bladder cancer_Homo sapiens_hsa052190.75140897
72Glutathione metabolism_Homo sapiens_hsa004800.74875987
73Steroid biosynthesis_Homo sapiens_hsa001000.72798378
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71987344
75Galactose metabolism_Homo sapiens_hsa000520.71805857
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70109253
77Cell cycle_Homo sapiens_hsa041100.67344186
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65860406
79mRNA surveillance pathway_Homo sapiens_hsa030150.65380122
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64403762
81Vitamin digestion and absorption_Homo sapiens_hsa049770.62010146
82ABC transporters_Homo sapiens_hsa020100.61621873
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61135326
84Dilated cardiomyopathy_Homo sapiens_hsa054140.60621200
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60418867
86Thyroid cancer_Homo sapiens_hsa052160.59844997
87Sulfur relay system_Homo sapiens_hsa041220.59831131
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59542032
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58781465
90Metabolic pathways_Homo sapiens_hsa011000.57272878
91Insulin resistance_Homo sapiens_hsa049310.57030726
92Alcoholism_Homo sapiens_hsa050340.55375586
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.53589349
94Chronic myeloid leukemia_Homo sapiens_hsa052200.53269238
95AMPK signaling pathway_Homo sapiens_hsa041520.52680507
96Non-small cell lung cancer_Homo sapiens_hsa052230.52539958
97Endocytosis_Homo sapiens_hsa041440.48714103
98Choline metabolism in cancer_Homo sapiens_hsa052310.48560610
99Glucagon signaling pathway_Homo sapiens_hsa049220.48367538
100Basal cell carcinoma_Homo sapiens_hsa052170.48053561
101Spliceosome_Homo sapiens_hsa030400.47420516
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.46953935
103VEGF signaling pathway_Homo sapiens_hsa043700.46650104
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45293221
105Proteasome_Homo sapiens_hsa030500.42915646
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40851853
107Oocyte meiosis_Homo sapiens_hsa041140.40609492
108Huntingtons disease_Homo sapiens_hsa050160.40472174
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36567408
110Viral carcinogenesis_Homo sapiens_hsa052030.35991467
111ECM-receptor interaction_Homo sapiens_hsa045120.35889058
112ErbB signaling pathway_Homo sapiens_hsa040120.34884745
113Small cell lung cancer_Homo sapiens_hsa052220.34552511
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.33162156
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32180605
116Tight junction_Homo sapiens_hsa045300.31814020
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.31698447
118Axon guidance_Homo sapiens_hsa043600.30915117
119Focal adhesion_Homo sapiens_hsa045100.30601377
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30220140
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.28042099
122Insulin signaling pathway_Homo sapiens_hsa049100.27290196
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25557529
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20315937
125DNA replication_Homo sapiens_hsa030300.18504448
126Pyrimidine metabolism_Homo sapiens_hsa002400.18347111
127RNA transport_Homo sapiens_hsa030130.18162700
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16140930
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15733482
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.12712628
131Systemic lupus erythematosus_Homo sapiens_hsa053220.11619952
132Linoleic acid metabolism_Homo sapiens_hsa005910.10454174
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09036776
134Cardiac muscle contraction_Homo sapiens_hsa042600.05978837
135Base excision repair_Homo sapiens_hsa034100.04753770
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.04535438
137Purine metabolism_Homo sapiens_hsa002300.03874690
138Parkinsons disease_Homo sapiens_hsa050120.03279041
139Mismatch repair_Homo sapiens_hsa034300.02536865
140HIF-1 signaling pathway_Homo sapiens_hsa040660.01823159
141Nucleotide excision repair_Homo sapiens_hsa034200.01193561
142Prion diseases_Homo sapiens_hsa050200.00872222

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