COG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.02245175
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.02245175
3endosome to pigment granule transport (GO:0043485)4.89362627
4endosome to melanosome transport (GO:0035646)4.89362627
5positive regulation of gamma-delta T cell activation (GO:0046645)4.71959245
6somatic diversification of immune receptors via somatic mutation (GO:0002566)4.53929783
7somatic hypermutation of immunoglobulin genes (GO:0016446)4.53929783
8COPI coating of Golgi vesicle (GO:0048205)4.50951090
9Golgi transport vesicle coating (GO:0048200)4.50951090
10antigen processing and presentation of endogenous antigen (GO:0019883)4.50305143
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46768011
12ribosome assembly (GO:0042255)4.30378617
13nuclear pore organization (GO:0006999)4.24447728
14nuclear pore complex assembly (GO:0051292)4.20308489
15non-recombinational repair (GO:0000726)4.18548751
16double-strand break repair via nonhomologous end joining (GO:0006303)4.18548751
17valine metabolic process (GO:0006573)4.06511659
18DNA strand elongation involved in DNA replication (GO:0006271)3.96021713
19ubiquinone biosynthetic process (GO:0006744)3.94193117
20purine nucleobase biosynthetic process (GO:0009113)3.82541318
21mitotic sister chromatid cohesion (GO:0007064)3.82260384
22regulation of gamma-delta T cell differentiation (GO:0045586)3.81871209
23telomere maintenance via semi-conservative replication (GO:0032201)3.78872901
24DNA strand elongation (GO:0022616)3.75274421
25regulation of gamma-delta T cell activation (GO:0046643)3.69005686
26ubiquinone metabolic process (GO:0006743)3.66692072
27nucleobase biosynthetic process (GO:0046112)3.60280464
28positive regulation of histone H3-K4 methylation (GO:0051571)3.58878568
29DNA replication checkpoint (GO:0000076)3.56919258
30telomere maintenance via recombination (GO:0000722)3.52508229
31mitochondrial RNA metabolic process (GO:0000959)3.48943987
32DNA replication initiation (GO:0006270)3.45670578
33tRNA aminoacylation for protein translation (GO:0006418)3.40157900
34tRNA aminoacylation (GO:0043039)3.39295897
35amino acid activation (GO:0043038)3.39295897
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.36869885
37somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.36869885
38isotype switching (GO:0045190)3.36869885
39pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.33563327
40UMP metabolic process (GO:0046049)3.33563327
41pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.33563327
42UMP biosynthetic process (GO:0006222)3.33563327
43somatic recombination of immunoglobulin gene segments (GO:0016447)3.32791719
44negative regulation of erythrocyte differentiation (GO:0045647)3.31885598
45quinone biosynthetic process (GO:1901663)3.31843615
46maturation of 5.8S rRNA (GO:0000460)3.28498678
47DNA double-strand break processing (GO:0000729)3.27107051
48protein localization to kinetochore (GO:0034501)3.25065490
49folic acid-containing compound biosynthetic process (GO:0009396)3.23125550
50transcription from mitochondrial promoter (GO:0006390)3.20829710
51IMP biosynthetic process (GO:0006188)3.20228013
52regulation of centriole replication (GO:0046599)3.20154387
53mitotic recombination (GO:0006312)3.19190865
54resolution of meiotic recombination intermediates (GO:0000712)3.17732967
55mitotic sister chromatid segregation (GO:0000070)3.17415190
56DNA unwinding involved in DNA replication (GO:0006268)3.17193861
57regulation of mitochondrial translation (GO:0070129)3.14460549
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.14385014
59NIK/NF-kappaB signaling (GO:0038061)3.14281046
60peptidyl-lysine dimethylation (GO:0018027)3.13318095
61somatic diversification of immunoglobulins (GO:0016445)3.12346014
62positive regulation of interferon-alpha production (GO:0032727)3.11485467
63RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11028666
64replication fork processing (GO:0031297)3.10434239
65thymic T cell selection (GO:0045061)3.09302521
66negative regulation of mRNA processing (GO:0050686)3.08293167
67antigen processing and presentation via MHC class Ib (GO:0002475)3.07140584
68somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.06521527
69somatic cell DNA recombination (GO:0016444)3.06521527
70Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06394045
71sister chromatid segregation (GO:0000819)3.03363502
72ncRNA catabolic process (GO:0034661)3.03085852
73chromatin remodeling at centromere (GO:0031055)3.00070715
74regulation of DNA endoreduplication (GO:0032875)2.99340358
75intra-S DNA damage checkpoint (GO:0031573)2.98835782
76regulation of helicase activity (GO:0051095)2.97766278
77tricarboxylic acid metabolic process (GO:0072350)2.97692273
78ribosome biogenesis (GO:0042254)2.97329863
79lactate metabolic process (GO:0006089)2.97133797
80CENP-A containing nucleosome assembly (GO:0034080)2.95977969
81positive regulation of natural killer cell differentiation (GO:0032825)2.95383767
82telomere maintenance (GO:0000723)2.94633591
83mitotic nuclear envelope disassembly (GO:0007077)2.94475682
84maturation of SSU-rRNA (GO:0030490)2.94394088
85negative thymic T cell selection (GO:0045060)2.94201802
86somatic diversification of immune receptors (GO:0002200)2.93944368
87DNA duplex unwinding (GO:0032508)2.93777149
88regulation of interferon-alpha production (GO:0032647)2.93474251
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93347774
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.93347774
91modulation by symbiont of host immune response (GO:0052553)2.93347774
92positive regulation by symbiont of host defense response (GO:0052509)2.93347774
93modulation by symbiont of host defense response (GO:0052031)2.93347774
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93347774
95pseudouridine synthesis (GO:0001522)2.92428297
96DNA geometric change (GO:0032392)2.91154635
97telomere organization (GO:0032200)2.89640825
98negative regulation of DNA recombination (GO:0045910)2.89097069
99postreplication repair (GO:0006301)2.88587377
100translesion synthesis (GO:0019985)2.88422955
101methionine biosynthetic process (GO:0009086)2.88262348
102pore complex assembly (GO:0046931)2.88146403
103rRNA catabolic process (GO:0016075)2.87244229
104low-density lipoprotein particle clearance (GO:0034383)2.86229517
105protein K6-linked ubiquitination (GO:0085020)2.86079388
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.85899861
107IMP metabolic process (GO:0046040)2.84363346
108regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84207078
109negative regulation of mRNA metabolic process (GO:1903312)2.83538407
110protein prenylation (GO:0018342)2.83517978
111prenylation (GO:0097354)2.83517978
112negative T cell selection (GO:0043383)2.82145849
113regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81612315
114protein localization to chromosome, centromeric region (GO:0071459)2.81040595
115regulation of translational fidelity (GO:0006450)2.80866667
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79933824
117response to type I interferon (GO:0034340)2.79863061
118branched-chain amino acid catabolic process (GO:0009083)2.79264850
119negative regulation of histone methylation (GO:0031061)2.79040020
120DNA strand renaturation (GO:0000733)2.78327101
121histone H2A acetylation (GO:0043968)2.78157947
122telomere maintenance via telomere lengthening (GO:0010833)2.77595509
123cellular response to type I interferon (GO:0071357)2.76657622
124type I interferon signaling pathway (GO:0060337)2.76657622
125double-strand break repair (GO:0006302)2.76115095
126positive regulation of translational initiation (GO:0045948)2.75594662
127L-serine metabolic process (GO:0006563)2.74199590
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.73889363
129regulation of response to interferon-gamma (GO:0060330)2.73420050
130cullin deneddylation (GO:0010388)2.73405073
131pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.73372456
132oxaloacetate metabolic process (GO:0006107)2.73240630
133recombinational repair (GO:0000725)2.72557555
134T cell selection (GO:0045058)2.72337845
135response to peptidoglycan (GO:0032494)2.72323421
136maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71729017
137DNA catabolic process, exonucleolytic (GO:0000738)2.70088195
138attachment of spindle microtubules to kinetochore (GO:0008608)2.69874463
139regulation of B cell receptor signaling pathway (GO:0050855)2.69291776
140folic acid-containing compound metabolic process (GO:0006760)2.69220993
141double-strand break repair via homologous recombination (GO:0000724)2.69153437
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68930068
143negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67173400
144natural killer cell differentiation (GO:0001779)2.66298906
145nucleotide salvage (GO:0043173)2.65342061
146B cell mediated immunity (GO:0019724)2.64589303
147JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64403338
148positive thymic T cell selection (GO:0045059)2.61688550
149regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.61075511
150positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60074259
151decidualization (GO:0046697)2.58458620
152cortical actin cytoskeleton organization (GO:0030866)2.58011290
153positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56393873
154regulation of interleukin-12 biosynthetic process (GO:0045075)2.55910498
155nucleoside salvage (GO:0043174)2.54013303
156response to interferon-alpha (GO:0035455)2.52345950
157immunoglobulin mediated immune response (GO:0016064)2.49011971
158positive regulation of B cell differentiation (GO:0045579)2.47495471
159negative regulation of interleukin-12 production (GO:0032695)2.44251087
160histone-serine phosphorylation (GO:0035404)2.43633385
161T cell apoptotic process (GO:0070231)2.43404774
162regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42515288
163T cell costimulation (GO:0031295)2.42146539
164lymphocyte costimulation (GO:0031294)2.40409204
165pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.40330383
166regulation of RIG-I signaling pathway (GO:0039535)2.39911714
167alpha-linolenic acid metabolic process (GO:0036109)2.39599679
168regulation of interferon-beta biosynthetic process (GO:0045357)2.39502587
169pyrimidine nucleoside salvage (GO:0043097)2.38822104
170pyrimidine-containing compound salvage (GO:0008655)2.38822104
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.37007059
172endoplasmic reticulum unfolded protein response (GO:0030968)2.33840566
173regulation of cholesterol storage (GO:0010885)2.31534792
174positive regulation of interferon-beta production (GO:0032728)2.29614553
175mannose metabolic process (GO:0006013)2.29512483
176regulation of B cell differentiation (GO:0045577)2.26219325
177negative regulation of multicellular organism growth (GO:0040015)2.26191187
178negative regulation of innate immune response (GO:0045824)2.25500220
1794-hydroxyproline metabolic process (GO:0019471)2.25022337
180cellular response to virus (GO:0098586)2.23760312
181regulation of fatty acid beta-oxidation (GO:0031998)2.23717673
182necroptotic process (GO:0070266)2.23282666
183positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.21678500
184response to muramyl dipeptide (GO:0032495)2.21051383
185cellular response to unfolded protein (GO:0034620)2.20579363
186response to vitamin D (GO:0033280)2.20491056
187negative regulation of fibrinolysis (GO:0051918)2.19038749
1882-oxoglutarate metabolic process (GO:0006103)2.18178858
189tetrahydrofolate metabolic process (GO:0046653)2.17011393
190negative regulation of phagocytosis (GO:0050765)2.16599824
191pteridine-containing compound biosynthetic process (GO:0042559)2.16181654
192lysine metabolic process (GO:0006553)2.15800138
193lysine catabolic process (GO:0006554)2.15800138
194ER-nucleus signaling pathway (GO:0006984)2.15046082
195B cell receptor signaling pathway (GO:0050853)2.13293417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92063497
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.65701689
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.53976160
4E2F7_22180533_ChIP-Seq_HELA_Human3.50203498
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.21513147
6MYC_22102868_ChIP-Seq_BL_Human2.89107464
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84119920
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72557183
9GATA1_22025678_ChIP-Seq_K562_Human2.58558225
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56035615
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52153260
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42127085
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.32341306
14YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31785011
15PADI4_21655091_ChIP-ChIP_MCF-7_Human2.30757607
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24692108
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20288631
18* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19051158
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.17304270
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13786836
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13771404
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.11550792
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09855732
24AR_21909140_ChIP-Seq_LNCAP_Human2.01665608
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01126688
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99576357
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96710532
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96649647
29KDM5A_27292631_Chip-Seq_BREAST_Human1.94825961
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93827239
31DCP1A_22483619_ChIP-Seq_HELA_Human1.93579003
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.93529014
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92611694
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91315028
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90637855
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.90028136
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89208722
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.83485257
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75161572
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73332269
41VDR_21846776_ChIP-Seq_THP-1_Human1.72413024
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71586285
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68336052
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67197111
45CIITA_25753668_ChIP-Seq_RAJI_Human1.66438006
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65902471
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65718034
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65499732
49TTF2_22483619_ChIP-Seq_HELA_Human1.64353413
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62519236
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61746678
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58981837
53* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58129204
54* MYB_26560356_Chip-Seq_TH2_Human1.56568278
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53556250
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53491935
57MAF_26560356_Chip-Seq_TH1_Human1.50465024
58UTX_26944678_Chip-Seq_JUKART_Human1.49973814
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49228050
60MYB_26560356_Chip-Seq_TH1_Human1.48407246
61SCL_19346495_ChIP-Seq_HPC-7_Human1.45619612
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45024274
63SPI1_23547873_ChIP-Seq_NB4_Human1.42857701
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.41916894
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41564975
66TFEB_21752829_ChIP-Seq_HELA_Human1.40843591
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.40277160
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38876243
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38057845
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36203169
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.35599287
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34640662
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34109116
74EWS_26573619_Chip-Seq_HEK293_Human1.33362192
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.33091038
76TCF7_22412390_ChIP-Seq_EML_Mouse1.32057276
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31320544
78* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30628010
79CLOCK_20551151_ChIP-Seq_293T_Human1.26895411
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26730948
81* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26157298
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25372132
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25057892
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24925239
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24786321
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24778594
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23444461
88MYC_18940864_ChIP-ChIP_HL60_Human1.23126311
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22742757
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22539343
91E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22005420
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.21925808
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20435882
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19588068
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.19462140
96FOXP3_21729870_ChIP-Seq_TREG_Human1.19200217
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.18105111
98MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16795072
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14646003
100* VDR_23849224_ChIP-Seq_CD4+_Human1.14084245
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13500428
102IGF1R_20145208_ChIP-Seq_DFB_Human1.13061674
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10795805
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10700371
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.10289834
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10149110
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10128163
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09704229
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09358213
110* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09271808
111GABP_19822575_ChIP-Seq_HepG2_Human1.09260103
112VDR_24763502_ChIP-Seq_THP-1_Human1.08595887
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.08277279
114FUS_26573619_Chip-Seq_HEK293_Human1.07500982
115POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07440356
116* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07146987
117MAF_26560356_Chip-Seq_TH2_Human1.06426223
118XRN2_22483619_ChIP-Seq_HELA_Human1.06336153
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06061117
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05720685
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.05346239
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05261968
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03700153
124RUNX_20019798_ChIP-Seq_JUKART_Human1.02993107
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02826063
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.02244384
127E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02122638
128* LXR_22292898_ChIP-Seq_THP-1_Human1.00690702
129SPI1_23127762_ChIP-Seq_K562_Human0.99644385
130E2F1_21310950_ChIP-Seq_MCF-7_Human0.98774660
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97818165
132ZNF274_21170338_ChIP-Seq_K562_Hela0.97055230
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.95384760
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94476943
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94200043
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94052390
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93920183
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92928569
139ELK1_19687146_ChIP-ChIP_HELA_Human0.92599285
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91663601
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91313830
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89645062
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.88689396
144CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86239743
145PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85259770
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82156266
147POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82091474
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.80782823
149CHD1_26751641_Chip-Seq_LNCaP_Human0.80516158
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.79964089
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79649960
152BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75777609
153* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73066887
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.72637730
155SALL4_22934838_ChIP-ChIP_CD34+_Human0.72354524
156IRF1_19129219_ChIP-ChIP_H3396_Human0.70145099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.33328065
2MP0010094_abnormal_chromosome_stability4.70807410
3MP0008058_abnormal_DNA_repair3.95929403
4MP0002009_preneoplasia3.11963815
5MP0001835_abnormal_antigen_presentation2.93042805
6MP0000685_abnormal_immune_system2.85784984
7MP0008007_abnormal_cellular_replicative2.73910210
8MP0003806_abnormal_nucleotide_metabolis2.54143421
9MP0003436_decreased_susceptibility_to2.33164955
10MP0003693_abnormal_embryo_hatching2.26579539
11MP0005671_abnormal_response_to2.26031607
12MP0003705_abnormal_hypodermis_morpholog2.23024597
13MP0009785_altered_susceptibility_to2.17195323
14MP0003763_abnormal_thymus_physiology2.15790631
15MP0005365_abnormal_bile_salt2.12530390
16MP0003786_premature_aging2.10716879
17MP0002139_abnormal_hepatobiliary_system2.08863971
18MP0001800_abnormal_humoral_immune2.00119089
19MP0000569_abnormal_digit_pigmentation1.99720497
20MP0009840_abnormal_foam_cell1.97838861
21MP0009697_abnormal_copulation1.94395648
22MP0005058_abnormal_lysosome_morphology1.93061498
23MP0008932_abnormal_embryonic_tissue1.90623612
24MP0008877_abnormal_DNA_methylation1.86883785
25MP0002837_dystrophic_cardiac_calcinosis1.84059356
26MP0010352_gastrointestinal_tract_polyps1.82998798
27MP0001790_abnormal_immune_system1.78810180
28MP0005387_immune_system_phenotype1.78810180
29MP0005360_urolithiasis1.78493870
30MP0005025_abnormal_response_to1.77768922
31MP0005000_abnormal_immune_tolerance1.77585614
32MP0006036_abnormal_mitochondrial_physio1.77562994
33MP0002452_abnormal_antigen_presenting1.76545604
34MP0002723_abnormal_immune_serum1.74002810
35MP0005464_abnormal_platelet_physiology1.72518756
36MP0002877_abnormal_melanocyte_morpholog1.71653678
37MP0009333_abnormal_splenocyte_physiolog1.71330316
38MP0002396_abnormal_hematopoietic_system1.70593846
39MP0002398_abnormal_bone_marrow1.70095179
40MP0002419_abnormal_innate_immunity1.65497461
41MP0002166_altered_tumor_susceptibility1.64222136
42MP0001853_heart_inflammation1.63072222
43MP0010234_abnormal_vibrissa_follicle1.62598857
44MP0006035_abnormal_mitochondrial_morpho1.62195321
45MP0003300_gastrointestinal_ulcer1.60260269
46MP0001819_abnormal_immune_cell1.58048418
47MP0002420_abnormal_adaptive_immunity1.57295632
48MP0003718_maternal_effect1.57061927
49MP0000609_abnormal_liver_physiology1.56090084
50MP0004947_skin_inflammation1.53754485
51MP0001661_extended_life_span1.52988443
52MP0003195_calcinosis1.52957101
53MP0002933_joint_inflammation1.52624630
54MP0005075_abnormal_melanosome_morpholog1.51806708
55MP0008469_abnormal_protein_level1.49715765
56MP0000716_abnormal_immune_system1.48496191
57MP0010155_abnormal_intestine_physiology1.44034887
58MP0000689_abnormal_spleen_morphology1.43596500
59MP0005319_abnormal_enzyme/_coenzyme1.43517355
60MP0005220_abnormal_exocrine_pancreas1.41865972
61MP0003303_peritoneal_inflammation1.41811568
62MP0000372_irregular_coat_pigmentation1.40997218
63MP0010307_abnormal_tumor_latency1.40288909
64MP0001845_abnormal_inflammatory_respons1.39217470
65MP0002722_abnormal_immune_system1.38631234
66MP0001764_abnormal_homeostasis1.37783712
67MP0002429_abnormal_blood_cell1.36279643
68MP0005379_endocrine/exocrine_gland_phen1.35541186
69MP0003566_abnormal_cell_adhesion1.35007843
70MP0006082_CNS_inflammation1.34637345
71MP0008438_abnormal_cutaneous_collagen1.34487960
72MP0003172_abnormal_lysosome_physiology1.33939544
73MP0004808_abnormal_hematopoietic_stem1.33643910
74MP0001533_abnormal_skeleton_physiology1.33325272
75MP0005408_hypopigmentation1.33040818
76MP0001873_stomach_inflammation1.30439646
77MP0004130_abnormal_muscle_cell1.30405479
78MP0005380_embryogenesis_phenotype1.28795528
79MP0001672_abnormal_embryogenesis/_devel1.28795528
80MP0010329_abnormal_lipoprotein_level1.28308925
81MP0001697_abnormal_embryo_size1.27804602
82MP0003724_increased_susceptibility_to1.27155039
83MP0000350_abnormal_cell_proliferation1.25567225
84MP0002006_tumorigenesis1.25137007
85MP0004084_abnormal_cardiac_muscle1.24575283
86MP0002938_white_spotting1.24012620
87MP0004233_abnormal_muscle_weight1.23762438
88MP0003984_embryonic_growth_retardation1.22324315
89MP0002163_abnormal_gland_morphology1.21224845
90MP0003252_abnormal_bile_duct1.20803730
91MP0004215_abnormal_myocardial_fiber1.20792559
92MP0002405_respiratory_system_inflammati1.19183388
93MP0002088_abnormal_embryonic_growth/wei1.19173681
94MP0006054_spinal_hemorrhage1.18859047
95MP0000371_diluted_coat_color1.18353927
96MP0000598_abnormal_liver_morphology1.15757799
97MP0000858_altered_metastatic_potential1.15251068
98MP0001986_abnormal_taste_sensitivity1.15225184
99MP0000427_abnormal_hair_cycle1.15097108
100MP0003937_abnormal_limbs/digits/tail_de1.14690980
101MP0005023_abnormal_wound_healing1.13129144
102MP0002909_abnormal_adrenal_gland1.12669099
103MP0000358_abnormal_cell_content/1.12660063
104MP0003191_abnormal_cellular_cholesterol1.11895663
105MP0008995_early_reproductive_senescence1.09546592
106MP0002148_abnormal_hypersensitivity_rea1.09389289
107MP0000490_abnormal_crypts_of1.09110931
108MP0001545_abnormal_hematopoietic_system1.07575160
109MP0005397_hematopoietic_system_phenotyp1.07575160
110MP0005253_abnormal_eye_physiology1.06970716
111MP0000465_gastrointestinal_hemorrhage1.06659974
112MP0005266_abnormal_metabolism1.06017632
113MP0001529_abnormal_vocalization1.05327160
114MP0002019_abnormal_tumor_incidence1.05097657
115MP0000703_abnormal_thymus_morphology1.04177900
116MP0004957_abnormal_blastocyst_morpholog1.03543173
117MP0005670_abnormal_white_adipose1.02773700
118MP0003186_abnormal_redox_activity1.02626408
119MP0001929_abnormal_gametogenesis1.01973579
120MP0005085_abnormal_gallbladder_physiolo1.01932146
121MP0003787_abnormal_imprinting1.01729523
122MP0000313_abnormal_cell_death1.00603251
123MP0002269_muscular_atrophy1.00439842
124MP0009763_increased_sensitivity_to1.00144012
125MP0004510_myositis1.00126774
126MP0006072_abnormal_retinal_apoptosis0.98485901
127MP0003111_abnormal_nucleus_morphology0.97956494
128MP0009643_abnormal_urine_homeostasis0.97584338
129MP0002084_abnormal_developmental_patter0.96077307
130MP0003077_abnormal_cell_cycle0.95422267
131MP0005310_abnormal_salivary_gland0.94142776
132MP0004264_abnormal_extraembryonic_tissu0.93551499
133MP0005666_abnormal_adipose_tissue0.93220124
134MP0003941_abnormal_skin_development0.91868242
135MP0008875_abnormal_xenobiotic_pharmacok0.91190703
136MP0002080_prenatal_lethality0.90917401
137MP0000015_abnormal_ear_pigmentation0.89632961
138MP0009115_abnormal_fat_cell0.89071650
139MP0001666_abnormal_nutrient_absorption0.88510462
140MP0001145_abnormal_male_reproductive0.86206337
141MP0003646_muscle_fatigue0.84577682
142MP0002138_abnormal_hepatobiliary_system0.83547617
143MP0004036_abnormal_muscle_relaxation0.83307287
144MP0010678_abnormal_skin_adnexa0.82788224
145MP0003866_abnormal_defecation0.82470640
146MP0005332_abnormal_amino_acid0.81933758
147MP0003890_abnormal_embryonic-extraembry0.81152148
148MP0001851_eye_inflammation0.80706061
149MP0003656_abnormal_erythrocyte_physiolo0.79899459
150MP0002638_abnormal_pupillary_reflex0.79514819
151MP0001730_embryonic_growth_arrest0.79469046
152MP0002693_abnormal_pancreas_physiology0.79259539
153MP0002210_abnormal_sex_determination0.79162950
154MP0005076_abnormal_cell_differentiation0.78666041
155MP0001915_intracranial_hemorrhage0.77890422
156MP0000653_abnormal_sex_gland0.77065051
157MP0000013_abnormal_adipose_tissue0.76831814
158MP0002078_abnormal_glucose_homeostasis0.76592730
159MP0002102_abnormal_ear_morphology0.76176576
160MP0002998_abnormal_bone_remodeling0.75043195
161MP0005375_adipose_tissue_phenotype0.74550056
162MP0002085_abnormal_embryonic_tissue0.74431334
163MP0002160_abnormal_reproductive_system0.73320209
164MP0005395_other_phenotype0.71575142
165MP0002234_abnormal_pharynx_morphology0.71429800
166MP0004197_abnormal_fetal_growth/weight/0.70520415
167MP0008775_abnormal_heart_ventricle0.70299567
168MP0001346_abnormal_lacrimal_gland0.69353008
169MP0008789_abnormal_olfactory_epithelium0.68633749
170MP0002090_abnormal_vision0.67224899
171MP0003221_abnormal_cardiomyocyte_apopto0.66280928
172MP0001119_abnormal_female_reproductive0.65097527
173MP0004381_abnormal_hair_follicle0.63252706
174MP0003121_genomic_imprinting0.62373477
175MP0004185_abnormal_adipocyte_glucose0.61909546
176MP0003868_abnormal_feces_composition0.61662207
177MP0002086_abnormal_extraembryonic_tissu0.61630712
178MP0005330_cardiomyopathy0.61128666

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.53705616
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50671273
3Abnormality of chromosome stability (HP:0003220)3.48064955
4Colon cancer (HP:0003003)3.37695618
5Autoimmune thrombocytopenia (HP:0001973)3.16553579
6Abnormality of the preputium (HP:0100587)3.10767024
7Abnormality of methionine metabolism (HP:0010901)3.04700151
8Thrombocytosis (HP:0001894)3.03420709
9Ependymoma (HP:0002888)3.02825242
10Type I transferrin isoform profile (HP:0003642)2.97915477
11Recurrent bronchitis (HP:0002837)2.96640682
12Rhabdomyosarcoma (HP:0002859)2.94810217
13Medulloblastoma (HP:0002885)2.93752250
14Astrocytoma (HP:0009592)2.90079734
15Abnormality of the astrocytes (HP:0100707)2.90079734
16Glioma (HP:0009733)2.88486696
17Multiple enchondromatosis (HP:0005701)2.86575912
18Increased cerebral lipofuscin (HP:0011813)2.85308681
19Nasal polyposis (HP:0100582)2.81189156
20Neoplasm of the adrenal gland (HP:0100631)2.80877971
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.77582998
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.70128265
23Abnormality of the ileum (HP:0001549)2.66497162
24Meckel diverticulum (HP:0002245)2.64689735
25Hand muscle atrophy (HP:0009130)2.63064343
26Abnormal protein glycosylation (HP:0012346)2.60733031
27Abnormal glycosylation (HP:0012345)2.60733031
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60733031
29Abnormal protein N-linked glycosylation (HP:0012347)2.60733031
30Abnormality of T cell number (HP:0011839)2.59952109
31T lymphocytopenia (HP:0005403)2.59767957
32Protrusio acetabuli (HP:0003179)2.59293251
33Eczematoid dermatitis (HP:0000976)2.58499687
34Myositis (HP:0100614)2.58128152
35Volvulus (HP:0002580)2.57409094
36Elevated erythrocyte sedimentation rate (HP:0003565)2.53468961
37Hypoplasia of the thymus (HP:0000778)2.51142619
38Renal cortical cysts (HP:0000803)2.50845293
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49406590
40Recurrent abscess formation (HP:0002722)2.48607654
41Recurrent fungal infections (HP:0002841)2.48385001
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47981299
43Neoplasm of the adrenal cortex (HP:0100641)2.46938938
44Abnormality of the nasal mucosa (HP:0000433)2.44869654
45Recurrent viral infections (HP:0004429)2.43404644
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39834305
47Late onset (HP:0003584)2.39681196
48Abnormality of T cells (HP:0002843)2.38271677
49Recurrent gram-negative bacterial infections (HP:0005420)2.38257980
50Vacuolated lymphocytes (HP:0001922)2.37659385
51Abnormality of the pons (HP:0007361)2.36498910
52Neuroendocrine neoplasm (HP:0100634)2.34885048
53IgM deficiency (HP:0002850)2.32138972
54Hypobetalipoproteinemia (HP:0003563)2.31629564
55Recurrent bacterial skin infections (HP:0005406)2.29830355
56Biliary tract neoplasm (HP:0100574)2.29686802
57Pancreatic islet-cell hyperplasia (HP:0004510)2.26249196
58Osteomyelitis (HP:0002754)2.25875059
59Cellulitis (HP:0100658)2.25588989
60Hypoglycemic coma (HP:0001325)2.23806536
61Hypoplasia of the pons (HP:0012110)2.23492721
62Acute necrotizing encephalopathy (HP:0006965)2.22467481
63Abnormality of T cell physiology (HP:0011840)2.21809482
64Chronic otitis media (HP:0000389)2.20951205
65Cutaneous melanoma (HP:0012056)2.20402337
66Increased serum lactate (HP:0002151)2.18639932
67Abnormality of proline metabolism (HP:0010907)2.18347676
68Hydroxyprolinuria (HP:0003080)2.18347676
69Spastic diplegia (HP:0001264)2.16801153
70Agammaglobulinemia (HP:0004432)2.16315394
71Biconcave vertebral bodies (HP:0004586)2.15337639
72Cerebral edema (HP:0002181)2.14695331
73Abnormal biliary tract morphology (HP:0012440)2.13829693
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13716924
75Abnormality of the parathyroid morphology (HP:0011766)2.13522454
76Epistaxis (HP:0000421)2.12761774
77Pheochromocytoma (HP:0002666)2.12202240
78Spinal muscular atrophy (HP:0007269)2.11742917
79Prominent nose (HP:0000448)2.11039405
80Agnosia (HP:0010524)2.10498817
81Joint swelling (HP:0001386)2.10448970
82IgA deficiency (HP:0002720)2.10374298
83Chronic diarrhea (HP:0002028)2.10325205
84Abnormality of homocysteine metabolism (HP:0010919)2.09269343
85Homocystinuria (HP:0002156)2.09269343
86Abnormal mitochondria in muscle tissue (HP:0008316)2.08754822
87Vertebral compression fractures (HP:0002953)2.08179100
88Subacute progressive viral hepatitis (HP:0006572)2.07760591
89Abnormality of the common coagulation pathway (HP:0010990)2.07692712
90Combined immunodeficiency (HP:0005387)2.07561076
91Metaphyseal cupping (HP:0003021)2.07531464
92Acute encephalopathy (HP:0006846)2.07282137
93Sloping forehead (HP:0000340)2.07066287
94Progressive muscle weakness (HP:0003323)2.06785095
95B lymphocytopenia (HP:0010976)2.06429473
96Abnormality of alanine metabolism (HP:0010916)2.06270752
97Hyperalaninemia (HP:0003348)2.06270752
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06270752
99Distal upper limb amyotrophy (HP:0007149)2.05887851
100Upper limb amyotrophy (HP:0009129)2.05887851
101Premature ovarian failure (HP:0008209)2.05735549
102Hyperglycinuria (HP:0003108)2.05534538
103Clubbing of toes (HP:0100760)2.05345420
104Increased CSF lactate (HP:0002490)2.04948701
105Concave nail (HP:0001598)2.04842187
106Oligodactyly (hands) (HP:0001180)2.04247547
107Small intestinal stenosis (HP:0012848)2.02691548
108Duodenal stenosis (HP:0100867)2.02691548
109Abnormality of macrophages (HP:0004311)2.01549545
110Arterial thrombosis (HP:0004420)1.99604655
111Myelodysplasia (HP:0002863)1.99309331
112Reduced subcutaneous adipose tissue (HP:0003758)1.99069999
113Mitral stenosis (HP:0001718)1.96269321
114Pulmonary infiltrates (HP:0002113)1.96129278
115Recurrent skin infections (HP:0001581)1.96126365
116Hypoplastic pelvis (HP:0008839)1.95918139
117Xanthomatosis (HP:0000991)1.95879817
118Metabolic acidosis (HP:0001942)1.95801131
119Abnormality of endocrine pancreas physiology (HP:0012093)1.95179044
120Abnormality of the pancreatic islet cells (HP:0006476)1.95179044
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94918889
122Abnormality of vitamin B metabolism (HP:0004340)1.94851429
123Progressive macrocephaly (HP:0004481)1.94738918
124Neoplasm of the small intestine (HP:0100833)1.94503753
125Deep venous thrombosis (HP:0002625)1.94314938
126Basal ganglia calcification (HP:0002135)1.93412677
127Reticulocytopenia (HP:0001896)1.92530504
128Verrucae (HP:0200043)1.91519662
129Papilloma (HP:0012740)1.91519662
130Hematochezia (HP:0002573)1.90393098
131Cervical subluxation (HP:0003308)1.89988512
132Cafe-au-lait spot (HP:0000957)1.89306064
133Abnormality of fatty-acid metabolism (HP:0004359)1.88680342
134Severe short stature (HP:0003510)1.88678698
135Reduced antithrombin III activity (HP:0001976)1.87949210
136Hyperinsulinemic hypoglycemia (HP:0000825)1.87762265
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87032182
138Medial flaring of the eyebrow (HP:0010747)1.87001233
139Insulin resistance (HP:0000855)1.86990529
140Nephroblastoma (Wilms tumor) (HP:0002667)1.86821035
141Increased IgM level (HP:0003496)1.86725302
142Severe combined immunodeficiency (HP:0004430)1.86662395
143Abnormality of the duodenum (HP:0002246)1.86543571
144Abnormality of B cell number (HP:0010975)1.86388309
145Persistence of primary teeth (HP:0006335)1.86191865
146Abnormality of DNA repair (HP:0003254)1.85735901
147Increased density of long bones (HP:0006392)1.85481946
148Stomatitis (HP:0010280)1.85209475
149Increased mean platelet volume (HP:0011877)1.85114371
150Autoimmune hemolytic anemia (HP:0001890)1.85014004
151Abnormal platelet volume (HP:0011876)1.84967847
152Recurrent cutaneous fungal infections (HP:0011370)1.84774024
153Chronic mucocutaneous candidiasis (HP:0002728)1.84774024
154Ketosis (HP:0001946)1.84583268
155Emphysema (HP:0002097)1.84346276
156Abnormality of the thoracic spine (HP:0100711)1.84129390
157Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83987654
158Pancytopenia (HP:0001876)1.83501318
159Selective tooth agenesis (HP:0001592)1.83184907
160Secondary amenorrhea (HP:0000869)1.82334447
161Poor head control (HP:0002421)1.82162751
162Pustule (HP:0200039)1.81702989
163Hemoptysis (HP:0002105)1.81656461
164Abnormality of the vitamin B12 metabolism (HP:0004341)1.81651820
165Radial bowing (HP:0002986)1.80566271
166Hepatic necrosis (HP:0002605)1.79872158
167Hypothermia (HP:0002045)1.79409665
168Ectopia lentis (HP:0001083)1.78917613
169Lethargy (HP:0001254)1.78651556
170Nonimmune hydrops fetalis (HP:0001790)1.78396025
171Aortic aneurysm (HP:0004942)1.77134699
172Methylmalonic acidemia (HP:0002912)1.76584159
173Basal cell carcinoma (HP:0002671)1.76292557
174Neoplasm of striated muscle (HP:0009728)1.76233446
175Neoplasm of the colon (HP:0100273)1.75235359
176Embryonal renal neoplasm (HP:0011794)1.75161381
177Abnormality of eosinophils (HP:0001879)1.75120171
178Ketoacidosis (HP:0001993)1.74508224
179Degeneration of anterior horn cells (HP:0002398)1.74031255
180Abnormality of the anterior horn cell (HP:0006802)1.74031255
181Gingivitis (HP:0000230)1.74018822
182Ovarian neoplasm (HP:0100615)1.73658042
183Orchitis (HP:0100796)1.73214634
184Abnormal cartilage morphology (HP:0002763)1.73068783
185Albinism (HP:0001022)1.72471429
186Beaking of vertebral bodies (HP:0004568)1.72435328
187Abnormality of serum amino acid levels (HP:0003112)1.72427101
188Mitochondrial inheritance (HP:0001427)1.71817776
189Hepatocellular necrosis (HP:0001404)1.71024608
190Freckling (HP:0001480)1.69267190
191Thyroiditis (HP:0100646)1.68384126
192Tubulointerstitial nephritis (HP:0001970)1.68144188
193Lactic acidosis (HP:0003128)1.68139592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.83395894
2PKN23.29949240
3SRPK13.07102872
4ZAK2.97201473
5TRIM282.91384104
6FRK2.89416946
7MAP4K12.84616651
8ERN12.61562440
9STK162.59992797
10PASK2.57138748
11TNK22.49061041
12MST42.47999576
13TESK22.42895870
14FGFR42.40808824
15JAK32.33511356
16EIF2AK12.31651269
17TYK22.24871977
18PBK2.19627723
19KIT2.19455597
20PDK22.16311058
21TBK12.01869245
22NUAK12.00233437
23BMX1.86925060
24MKNK11.84234631
25FLT31.82783375
26TAF11.82742003
27TAOK21.82116480
28TESK11.79207434
29TXK1.75565527
30LRRK21.75354731
31EEF2K1.75241225
32MAP3K101.69669526
33JAK11.67924487
34TTK1.66167234
35MAP3K141.64208975
36ACVR1B1.61971585
37BRD41.60380167
38MKNK21.57216631
39VRK21.56529042
40ZAP701.53327029
41PLK41.52744440
42VRK11.43843382
43SIK11.42980716
44IKBKE1.41229944
45PLK31.35839830
46PTK61.34920858
47BCR1.34444198
48TTN1.30275407
49EPHA31.29749376
50INSRR1.26346840
51CSNK1G11.25576784
52CAMKK21.25193591
53PLK11.24611483
54STK391.17780750
55MAP3K41.17422445
56STK101.16155039
57NEK21.15978503
58CSK1.12656944
59PDGFRA1.12328180
60AURKB1.10658726
61OBSCN1.08604373
62CAMKK11.08554399
63CSNK1G31.07351465
64ATM1.07099717
65PRPF4B1.06848502
66SCYL21.06477178
67CSF1R1.06114616
68BMPR1B1.02761345
69WNK31.02110094
70BRSK21.00707957
71BTK1.00010601
72NME20.99509335
73TAOK30.99372746
74WEE10.98501344
75MAP3K130.97847165
76CHEK10.97210112
77BCKDK0.95499540
78NME10.94994228
79PAK40.94216494
80CHEK20.92182350
81MAP4K20.91855137
82MUSK0.90874768
83IKBKB0.90023424
84ITK0.88806291
85MAP3K110.87486952
86HCK0.86285432
87KDR0.85259514
88CDK40.84559398
89JAK20.83920782
90ALK0.83845682
91FGFR30.83244318
92GRK60.81878281
93EIF2AK30.80200221
94CDK120.79324573
95TLK10.79133006
96SYK0.77695798
97MAP2K30.76792195
98CDK30.75311646
99PIK3CG0.74517847
100CSNK1A1L0.73476641
101NLK0.71500298
102LCK0.71477235
103OXSR10.69387901
104CHUK0.69235600
105LYN0.67617843
106MELK0.67549733
107CSNK1G20.67248981
108TEC0.65282299
109PIM10.64820647
110MAPK110.64682687
111RPS6KB20.64248176
112EIF2AK20.63189441
113PRKAA20.62783358
114PIM20.62778495
115CAMK1G0.60630389
116CSNK2A20.60470018
117BLK0.59637297
118CDC70.59574583
119RPS6KA50.58603984
120MATK0.58428599
121BRSK10.57562304
122NEK90.57311839
123CDK20.55550622
124AKT30.55323997
125LATS10.54738460
126RPS6KB10.54086853
127TGFBR10.53516707
128IRAK30.52923854
129STK30.51875805
130SIK30.51860513
131FGFR20.50850622
132PRKDC0.50268437
133CDK70.49477338
134CSNK1E0.49278405
135BUB10.47810953
136CSNK1A10.47531613
137CDK10.47122613
138MAP3K80.47006030
139NEK60.46789517
140CLK10.44116882
141CSNK2A10.43929096
142ERBB30.42738725
143MAP3K50.42476346
144CDK60.39658472
145NEK10.39040767
146SMG10.38863812
147MAP3K70.38704027
148DDR20.37181899
149MTOR0.36807159
150PDK40.35696532
151PDK30.35696532
152TGFBR20.35574792
153PHKG10.33953794
154PHKG20.33953794
155CAMK1D0.32888188
156STK40.32070419
157RPS6KA40.31928810
158TSSK60.31885802
159IRAK10.31732977
160AKT20.31473572
161ATR0.31239347
162PTK20.30260213
163PRKCH0.30100291
164IRAK40.30067574

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.74394991
2Non-homologous end-joining_Homo sapiens_hsa034503.54771632
3Caffeine metabolism_Homo sapiens_hsa002323.10084007
4Homologous recombination_Homo sapiens_hsa034402.61104102
5Fanconi anemia pathway_Homo sapiens_hsa034602.43412787
6Selenocompound metabolism_Homo sapiens_hsa004502.33503100
7Nucleotide excision repair_Homo sapiens_hsa034202.24764653
8Primary immunodeficiency_Homo sapiens_hsa053402.15208613
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05960759
10RNA degradation_Homo sapiens_hsa030181.99121064
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92492136
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.75488422
13Measles_Homo sapiens_hsa051621.72759226
14Antigen processing and presentation_Homo sapiens_hsa046121.63277840
15One carbon pool by folate_Homo sapiens_hsa006701.59184646
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57825961
17Fatty acid degradation_Homo sapiens_hsa000711.56044583
18Protein export_Homo sapiens_hsa030601.55031342
19Leishmaniasis_Homo sapiens_hsa051401.54531831
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.51211695
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47424337
22Cell cycle_Homo sapiens_hsa041101.46631945
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45922652
24Ribosome_Homo sapiens_hsa030101.45365869
25Folate biosynthesis_Homo sapiens_hsa007901.43818854
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42398008
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38044389
28Legionellosis_Homo sapiens_hsa051341.37429589
29Staphylococcus aureus infection_Homo sapiens_hsa051501.37039444
30Purine metabolism_Homo sapiens_hsa002301.36784699
31Basal transcription factors_Homo sapiens_hsa030221.36248426
32B cell receptor signaling pathway_Homo sapiens_hsa046621.29719291
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.29497567
34Butanoate metabolism_Homo sapiens_hsa006501.28545623
35Sulfur relay system_Homo sapiens_hsa041221.26934082
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25558450
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.25477854
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25239837
39Herpes simplex infection_Homo sapiens_hsa051681.24206088
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.23591575
41Galactose metabolism_Homo sapiens_hsa000521.23093119
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20564012
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20037706
44Fructose and mannose metabolism_Homo sapiens_hsa000511.19552557
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.19536791
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18184749
47T cell receptor signaling pathway_Homo sapiens_hsa046601.17156557
48Acute myeloid leukemia_Homo sapiens_hsa052211.16855428
49Lysine degradation_Homo sapiens_hsa003101.16704840
50Vitamin B6 metabolism_Homo sapiens_hsa007501.16471454
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15287807
52Pentose phosphate pathway_Homo sapiens_hsa000301.14407987
53Allograft rejection_Homo sapiens_hsa053301.14061627
54mRNA surveillance pathway_Homo sapiens_hsa030151.13145335
55Other glycan degradation_Homo sapiens_hsa005111.13079418
56Carbon metabolism_Homo sapiens_hsa012001.11285049
57Osteoclast differentiation_Homo sapiens_hsa043801.08370928
58Apoptosis_Homo sapiens_hsa042101.06722358
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06238406
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06006411
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05472429
62Insulin resistance_Homo sapiens_hsa049311.04273831
63Toxoplasmosis_Homo sapiens_hsa051451.02398319
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01541909
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98472416
66Circadian rhythm_Homo sapiens_hsa047100.98083116
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98027576
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97791741
69Oxidative phosphorylation_Homo sapiens_hsa001900.97551163
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96195639
71DNA replication_Homo sapiens_hsa030300.95223107
72PPAR signaling pathway_Homo sapiens_hsa033200.95127162
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94878379
74Propanoate metabolism_Homo sapiens_hsa006400.94741030
75Viral carcinogenesis_Homo sapiens_hsa052030.94306696
76Hematopoietic cell lineage_Homo sapiens_hsa046400.93496779
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.93303684
78Base excision repair_Homo sapiens_hsa034100.92817564
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92723376
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92497314
81Lysosome_Homo sapiens_hsa041420.90804115
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89848155
83Hepatitis B_Homo sapiens_hsa051610.89034241
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.89007057
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.88840809
86Chronic myeloid leukemia_Homo sapiens_hsa052200.88830898
87Influenza A_Homo sapiens_hsa051640.88771391
88Systemic lupus erythematosus_Homo sapiens_hsa053220.87800927
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85984381
90ABC transporters_Homo sapiens_hsa020100.85681911
91Fatty acid elongation_Homo sapiens_hsa000620.83567954
92Shigellosis_Homo sapiens_hsa051310.83440092
93Spliceosome_Homo sapiens_hsa030400.82894175
94Glutathione metabolism_Homo sapiens_hsa004800.81050812
95N-Glycan biosynthesis_Homo sapiens_hsa005100.79852332
96Epstein-Barr virus infection_Homo sapiens_hsa051690.79519764
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79191462
98Complement and coagulation cascades_Homo sapiens_hsa046100.78989797
99p53 signaling pathway_Homo sapiens_hsa041150.77528710
100Type I diabetes mellitus_Homo sapiens_hsa049400.76953022
101Pyruvate metabolism_Homo sapiens_hsa006200.76651697
102mTOR signaling pathway_Homo sapiens_hsa041500.76062842
103Tryptophan metabolism_Homo sapiens_hsa003800.75922385
104Parkinsons disease_Homo sapiens_hsa050120.74635816
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74559001
106Sulfur metabolism_Homo sapiens_hsa009200.74165972
107Nitrogen metabolism_Homo sapiens_hsa009100.72341728
108Metabolic pathways_Homo sapiens_hsa011000.71863445
109Fatty acid metabolism_Homo sapiens_hsa012120.71561699
110Huntingtons disease_Homo sapiens_hsa050160.71548179
111Arginine biosynthesis_Homo sapiens_hsa002200.70994754
112Insulin signaling pathway_Homo sapiens_hsa049100.70702251
113TNF signaling pathway_Homo sapiens_hsa046680.70430516
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66766854
115Tuberculosis_Homo sapiens_hsa051520.65309143
116Peroxisome_Homo sapiens_hsa041460.64852320
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63784940
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63455678
119Steroid biosynthesis_Homo sapiens_hsa001000.62812391
120beta-Alanine metabolism_Homo sapiens_hsa004100.61405073
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61107817
122Pyrimidine metabolism_Homo sapiens_hsa002400.60812679
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60182348
124Malaria_Homo sapiens_hsa051440.59730741
125Regulation of autophagy_Homo sapiens_hsa041400.59458236
126Small cell lung cancer_Homo sapiens_hsa052220.59051323
127Graft-versus-host disease_Homo sapiens_hsa053320.57750816
128HTLV-I infection_Homo sapiens_hsa051660.57415960
129Proteasome_Homo sapiens_hsa030500.55477772
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55062474
131Arginine and proline metabolism_Homo sapiens_hsa003300.54307295
132Starch and sucrose metabolism_Homo sapiens_hsa005000.54121381
133RNA transport_Homo sapiens_hsa030130.53462238
134RNA polymerase_Homo sapiens_hsa030200.53454394
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53158610
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.51901142
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50772698
138Alcoholism_Homo sapiens_hsa050340.39370825
139Glycerolipid metabolism_Homo sapiens_hsa005610.36943013
140Inositol phosphate metabolism_Homo sapiens_hsa005620.36669490
141Oocyte meiosis_Homo sapiens_hsa041140.35227868
142Glucagon signaling pathway_Homo sapiens_hsa049220.32405686
143Alzheimers disease_Homo sapiens_hsa050100.31050023
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30423341
145Sphingolipid metabolism_Homo sapiens_hsa006000.23928750
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.23534304
147Vitamin digestion and absorption_Homo sapiens_hsa049770.23003939
148Fat digestion and absorption_Homo sapiens_hsa049750.21113743
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20278403
150Fatty acid biosynthesis_Homo sapiens_hsa000610.19508746
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17533417
152Thyroid cancer_Homo sapiens_hsa052160.14452267
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13077453

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