CNTRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.51589082
2negative T cell selection (GO:0043383)4.43974358
3negative thymic T cell selection (GO:0045060)4.38300704
4regulation of gamma-delta T cell differentiation (GO:0045586)4.25496036
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.20328032
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20328032
7positive thymic T cell selection (GO:0045059)4.15380026
8regulation of B cell receptor signaling pathway (GO:0050855)4.07082436
9antigen processing and presentation of endogenous antigen (GO:0019883)4.06885199
10negative regulation of cell killing (GO:0031342)4.01561234
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.01561234
12regulation of gamma-delta T cell activation (GO:0046643)4.00206537
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98688847
14centriole replication (GO:0007099)3.77211987
15T cell migration (GO:0072678)3.63247064
16B cell receptor signaling pathway (GO:0050853)3.61874538
17thymic T cell selection (GO:0045061)3.59623454
18positive T cell selection (GO:0043368)3.58882131
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53511870
20regulation of B cell differentiation (GO:0045577)3.51081635
21positive regulation of B cell differentiation (GO:0045579)3.49241774
22T cell selection (GO:0045058)3.47727502
23activated T cell proliferation (GO:0050798)3.47454758
24mucosal-associated lymphoid tissue development (GO:0048537)3.43524134
25Peyers patch development (GO:0048541)3.43524134
26mitotic sister chromatid cohesion (GO:0007064)3.37490161
27negative regulation of T cell mediated immunity (GO:0002710)3.33839940
28leukocyte aggregation (GO:0070486)3.33663030
29interferon-gamma production (GO:0032609)3.32386729
30peptidyl-lysine trimethylation (GO:0018023)3.31202251
31meiotic chromosome segregation (GO:0045132)3.29033509
32tolerance induction (GO:0002507)3.24800149
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22673734
34negative regulation of phagocytosis (GO:0050765)3.21167745
35nuclear pore complex assembly (GO:0051292)3.20206789
36regulation of granulocyte differentiation (GO:0030852)3.17236013
37regulation of alpha-beta T cell proliferation (GO:0046640)3.15006546
38NIK/NF-kappaB signaling (GO:0038061)3.14753876
39regulation of DNA endoreduplication (GO:0032875)3.11348793
40response to interleukin-15 (GO:0070672)3.11043381
41T cell homeostasis (GO:0043029)3.04220889
42mast cell activation (GO:0045576)3.02288203
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01587778
44kinetochore organization (GO:0051383)3.00330871
45mitotic chromosome condensation (GO:0007076)2.98021198
46cell wall macromolecule catabolic process (GO:0016998)2.96797956
47antigen receptor-mediated signaling pathway (GO:0050851)2.95698119
48phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.91185998
49regulation of tolerance induction (GO:0002643)2.90985064
50negative regulation of lymphocyte mediated immunity (GO:0002707)2.90870926
51centriole assembly (GO:0098534)2.87348464
52regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86021072
53DNA topological change (GO:0006265)2.85891102
54cellular response to interleukin-15 (GO:0071350)2.85328558
55nuclear pore organization (GO:0006999)2.85037656
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84984121
57DNA unwinding involved in DNA replication (GO:0006268)2.84836754
58defense response to protozoan (GO:0042832)2.83848684
59negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83682082
60neural tube formation (GO:0001841)2.83072019
61hepatocyte apoptotic process (GO:0097284)2.83044632
62neutrophil activation involved in immune response (GO:0002283)2.81879307
63lymphocyte homeostasis (GO:0002260)2.81281912
64positive regulation of isotype switching (GO:0045830)2.79684393
65negative regulation of adaptive immune response (GO:0002820)2.79669197
66T cell receptor signaling pathway (GO:0050852)2.79149359
67positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78914869
68histone H3-K36 demethylation (GO:0070544)2.78484236
69regulation of interleukin-12 biosynthetic process (GO:0045075)2.77695433
70positive regulation of histone H3-K4 methylation (GO:0051571)2.76695874
71regulation of histone H3-K9 methylation (GO:0051570)2.76286093
72interkinetic nuclear migration (GO:0022027)2.75771271
73monoubiquitinated protein deubiquitination (GO:0035520)2.75367195
74definitive hemopoiesis (GO:0060216)2.74456986
75protein localization to kinetochore (GO:0034501)2.73507599
76cellular extravasation (GO:0045123)2.72292718
77alpha-beta T cell activation (GO:0046631)2.71785023
78microglial cell activation (GO:0001774)2.69614671
79positive regulation of B cell activation (GO:0050871)2.69556413
80V(D)J recombination (GO:0033151)2.69382276
81B cell homeostasis (GO:0001782)2.69347718
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68844628
83histone H3-K9 modification (GO:0061647)2.67419181
84regulation of mast cell activation (GO:0033003)2.67299819
85histone H3-K9 methylation (GO:0051567)2.67254854
86histone H3-K4 trimethylation (GO:0080182)2.67091706
87response to protozoan (GO:0001562)2.66897756
88positive regulation of defense response to virus by host (GO:0002230)2.66732643
89cellular response to interferon-beta (GO:0035458)2.66269067
90histone H3-K4 methylation (GO:0051568)2.66145322
91neutrophil mediated immunity (GO:0002446)2.66068127
92pore complex assembly (GO:0046931)2.65786782
93alpha-beta T cell differentiation (GO:0046632)2.65411776
94T cell costimulation (GO:0031295)2.65183248
95positive regulation of mast cell activation (GO:0033005)2.64079367
96B cell mediated immunity (GO:0019724)2.62527298
97negative regulation of T-helper cell differentiation (GO:0045623)2.62393233
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62393233
99translesion synthesis (GO:0019985)2.62370925
100mature B cell differentiation (GO:0002335)2.62025685
101regulation of B cell activation (GO:0050864)2.61254363
102detection of other organism (GO:0098543)2.60866770
103lymphocyte costimulation (GO:0031294)2.60406489
104natural killer cell differentiation (GO:0001779)2.60178801
105protein localization to chromosome, centromeric region (GO:0071459)2.59938746
106myeloid dendritic cell activation (GO:0001773)2.59547205
107detection of bacterium (GO:0016045)2.59214714
108sister chromatid segregation (GO:0000819)2.58792374
109positive regulation of interleukin-2 production (GO:0032743)2.58741163
110negative regulation of leukocyte mediated immunity (GO:0002704)2.58084988
111antigen processing and presentation via MHC class Ib (GO:0002475)2.57018686
112regulation of alpha-beta T cell activation (GO:0046634)2.56775734
113B cell activation (GO:0042113)2.55991563
114megakaryocyte development (GO:0035855)2.55734832
115mitotic recombination (GO:0006312)2.55127279
116negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54762442
117regulation of interleukin-2 biosynthetic process (GO:0045076)2.52154518
118telomere maintenance via recombination (GO:0000722)2.52090964
119negative regulation of B cell proliferation (GO:0030889)2.51451932
120mast cell activation involved in immune response (GO:0002279)2.51373320
121mast cell degranulation (GO:0043303)2.51373320
122regulation of necroptotic process (GO:0060544)2.51310427
123myeloid cell activation involved in immune response (GO:0002275)2.50914522
124regulation of T cell receptor signaling pathway (GO:0050856)2.49916273
125regulation of isotype switching to IgG isotypes (GO:0048302)2.49534960
126regulation of T cell tolerance induction (GO:0002664)2.49418423
127DNA duplex unwinding (GO:0032508)2.48963597
128histone mRNA catabolic process (GO:0071044)2.48507804
129cellular response to zinc ion (GO:0071294)2.48090483
130DNA geometric change (GO:0032392)2.46885285
131leukocyte homeostasis (GO:0001776)2.45561647
132positive regulation of granulocyte differentiation (GO:0030854)2.44544399
133telomere maintenance via semi-conservative replication (GO:0032201)2.43497185
134negative regulation of histone methylation (GO:0031061)2.40313107
135germinal center formation (GO:0002467)2.39981446
136neutrophil activation (GO:0042119)2.38335408
137telomere maintenance (GO:0000723)2.37647380
138negative regulation of granulocyte differentiation (GO:0030853)2.37386298
139positive regulation of DNA recombination (GO:0045911)2.37262550
140dosage compensation (GO:0007549)2.36870729
141telomere organization (GO:0032200)2.36374907
142positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.36123637
143T cell proliferation (GO:0042098)2.35613478
144T cell differentiation (GO:0030217)2.35467742
145mitotic sister chromatid segregation (GO:0000070)2.33785422
146immunoglobulin mediated immune response (GO:0016064)2.33522400
147ribosomal small subunit assembly (GO:0000028)2.31641575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.91689406
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03567880
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.37863367
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91151330
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.90756207
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.36738571
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27861936
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.20120994
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.90937748
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.81146132
11MYC_22102868_ChIP-Seq_BL_Human2.76431404
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.66279350
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57735418
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57661065
15SCL_19346495_ChIP-Seq_HPC-7_Human2.52543891
16MYB_26560356_Chip-Seq_TH2_Human2.45113565
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.42382046
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39696088
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34388161
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32667957
21RUNX_20019798_ChIP-Seq_JUKART_Human2.27965275
22VDR_21846776_ChIP-Seq_THP-1_Human2.26984664
23MYB_26560356_Chip-Seq_TH1_Human2.26674177
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26663136
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14891146
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13385769
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.10446699
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09180626
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.07670037
30MAF_26560356_Chip-Seq_TH1_Human2.07222135
31SPI1_23547873_ChIP-Seq_NB4_Human2.03040938
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01843185
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95287960
34UTX_26944678_Chip-Seq_JUKART_Human1.85753974
35CIITA_25753668_ChIP-Seq_RAJI_Human1.82468461
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.78197326
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.77884150
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.73131923
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70735514
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70334763
41VDR_24763502_ChIP-Seq_THP-1_Human1.70042217
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66822821
43TCF7_22412390_ChIP-Seq_EML_Mouse1.61761202
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60297558
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59693367
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52689633
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49792076
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.49578885
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47873262
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43800559
51FOXP3_21729870_ChIP-Seq_TREG_Human1.41769767
52VDR_24787735_ChIP-Seq_THP-1_Human1.39887184
53VDR_23849224_ChIP-Seq_CD4+_Human1.39733345
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38607749
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37663558
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.36816035
57GATA3_27048872_Chip-Seq_THYMUS_Human1.35197640
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34837394
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34700814
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31018462
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29484762
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29126133
63VDR_22108803_ChIP-Seq_LS180_Human1.28852599
64MAF_26560356_Chip-Seq_TH2_Human1.27171615
65PU_27001747_Chip-Seq_BMDM_Mouse1.26986110
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26602958
67EWS_26573619_Chip-Seq_HEK293_Human1.25763391
68ELK1_19687146_ChIP-ChIP_HELA_Human1.24911709
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.24042712
70SPI1_23127762_ChIP-Seq_K562_Human1.23720426
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23587874
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20784018
73GATA1_22025678_ChIP-Seq_K562_Human1.19966263
74IGF1R_20145208_ChIP-Seq_DFB_Human1.17713751
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13441658
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13370693
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12916564
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11389040
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09293060
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09087797
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06382434
82SMRT_27268052_Chip-Seq_Bcells_Human1.04805418
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04670987
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04011508
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02347841
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02235374
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01569775
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00952263
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00135833
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99702778
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98916205
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.98634457
93GATA3_26560356_Chip-Seq_TH1_Human0.97971907
94ER_23166858_ChIP-Seq_MCF-7_Human0.97802727
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97672995
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97567624
97KDM5A_27292631_Chip-Seq_BREAST_Human0.97247631
98AR_21909140_ChIP-Seq_LNCAP_Human0.96858558
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96715698
100EST1_17652178_ChIP-ChIP_JURKAT_Human0.95502291
101MYC_18555785_ChIP-Seq_MESCs_Mouse0.95327612
102GATA3_26560356_Chip-Seq_TH2_Human0.93881681
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93723163
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92567395
105SALL4_22934838_ChIP-ChIP_CD34+_Human0.92490950
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88842658
107TAF15_26573619_Chip-Seq_HEK293_Human0.87877611
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87526752
109FUS_26573619_Chip-Seq_HEK293_Human0.86865461
110NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85798460
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85776249
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85466169
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84608402
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.84402684
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83953888
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83206876
117MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83066917
118TFEB_21752829_ChIP-Seq_HELA_Human0.82055391
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81656621
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81656621
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81522398
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81424287
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81356007
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81035411
125ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80547676
126KDM2B_26808549_Chip-Seq_DND41_Human0.80288451
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77782445
128XRN2_22483619_ChIP-Seq_HELA_Human0.76443640
129CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75933400
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72562197

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.58800887
2MP0003763_abnormal_thymus_physiology3.44678205
3MP0002396_abnormal_hematopoietic_system3.40934156
4MP0005671_abnormal_response_to3.13057504
5MP0001800_abnormal_humoral_immune2.96155211
6MP0008057_abnormal_DNA_replication2.82038283
7MP0000685_abnormal_immune_system2.79403155
8MP0010094_abnormal_chromosome_stability2.56281954
9MP0005387_immune_system_phenotype2.51534587
10MP0001790_abnormal_immune_system2.51534587
11MP0002398_abnormal_bone_marrow2.49470174
12MP0002452_abnormal_antigen_presenting2.49018088
13MP0002166_altered_tumor_susceptibility2.47524112
14MP0002420_abnormal_adaptive_immunity2.40650722
15MP0005000_abnormal_immune_tolerance2.38334321
16MP0001819_abnormal_immune_cell2.37259975
17MP0004808_abnormal_hematopoietic_stem2.36157870
18MP0002723_abnormal_immune_serum2.35850438
19MP0000569_abnormal_digit_pigmentation2.33838064
20MP0003436_decreased_susceptibility_to2.21772648
21MP0000716_abnormal_immune_system2.15198084
22MP0000703_abnormal_thymus_morphology2.08569955
23MP0005025_abnormal_response_to2.06051574
24MP0000689_abnormal_spleen_morphology2.05451070
25MP0002006_tumorigenesis2.02112803
26MP0002722_abnormal_immune_system2.01591260
27MP0003077_abnormal_cell_cycle2.00682775
28MP0002405_respiratory_system_inflammati2.00140240
29MP0009785_altered_susceptibility_to2.00121471
30MP0001873_stomach_inflammation1.95751736
31MP0009333_abnormal_splenocyte_physiolog1.93700923
32MP0008058_abnormal_DNA_repair1.92718594
33MP0003111_abnormal_nucleus_morphology1.92387155
34MP0002419_abnormal_innate_immunity1.91625268
35MP0003693_abnormal_embryo_hatching1.84242330
36MP0005174_abnormal_tail_pigmentation1.83535442
37MP0002429_abnormal_blood_cell1.83372053
38MP0002148_abnormal_hypersensitivity_rea1.82421637
39MP0005464_abnormal_platelet_physiology1.81919185
40MP0003303_peritoneal_inflammation1.75045228
41MP0010155_abnormal_intestine_physiology1.72000073
42MP0009278_abnormal_bone_marrow1.69458715
43MP0003300_gastrointestinal_ulcer1.66171466
44MP0005397_hematopoietic_system_phenotyp1.65621514
45MP0001545_abnormal_hematopoietic_system1.65621514
46MP0008877_abnormal_DNA_methylation1.63822646
47MP0001853_heart_inflammation1.60060552
48MP0010307_abnormal_tumor_latency1.50501347
49MP0000490_abnormal_crypts_of1.50416166
50MP0008007_abnormal_cellular_replicative1.44904778
51MP0001845_abnormal_inflammatory_respons1.37774014
52MP0006082_CNS_inflammation1.36063568
53MP0004947_skin_inflammation1.35848711
54MP0003866_abnormal_defecation1.31788445
55MP0000465_gastrointestinal_hemorrhage1.31663641
56MP0002019_abnormal_tumor_incidence1.26629949
57MP0005076_abnormal_cell_differentiation1.21217794
58MP0005075_abnormal_melanosome_morpholog1.19734463
59MP0002009_preneoplasia1.19515093
60MP0000372_irregular_coat_pigmentation1.14173731
61MP0003787_abnormal_imprinting1.12995195
62MP0004957_abnormal_blastocyst_morpholog1.12627344
63MP0000015_abnormal_ear_pigmentation1.10398020
64MP0002933_joint_inflammation1.07159770
65MP0003724_increased_susceptibility_to1.06861048
66MP0001986_abnormal_taste_sensitivity1.05734847
67MP0010352_gastrointestinal_tract_polyps1.05147386
68MP0000858_altered_metastatic_potential1.04340819
69MP0003656_abnormal_erythrocyte_physiolo1.03375791
70MP0002095_abnormal_skin_pigmentation1.02287337
71MP0006054_spinal_hemorrhage1.02029745
72MP0002132_abnormal_respiratory_system1.00494407
73MP0008995_early_reproductive_senescence0.99752208
74MP0000350_abnormal_cell_proliferation0.98664933
75MP0000313_abnormal_cell_death0.91825392
76MP0003183_abnormal_peptide_metabolism0.90307555
77MP0003448_altered_tumor_morphology0.86001053
78MP0008469_abnormal_protein_level0.85334276
79MP0003943_abnormal_hepatobiliary_system0.84244970
80MP0005310_abnormal_salivary_gland0.84011559
81MP0001533_abnormal_skeleton_physiology0.82341617
82MP0009765_abnormal_xenobiotic_induced0.81618025
83MP0002928_abnormal_bile_duct0.80871206
84MP0009764_decreased_sensitivity_to0.79301893
85MP0001851_eye_inflammation0.78521060
86MP0001915_intracranial_hemorrhage0.76285050
87MP0008961_abnormal_basal_metabolism0.75943539
88MP0004883_abnormal_blood_vessel0.75490409
89MP0003786_premature_aging0.73267840
90MP0001929_abnormal_gametogenesis0.70778067
91MP0009115_abnormal_fat_cell0.70699651
92MP0003045_fibrosis0.70229559
93MP0003121_genomic_imprinting0.69831862
94MP0000371_diluted_coat_color0.68958750
95MP0004381_abnormal_hair_follicle0.67375454
96MP0005266_abnormal_metabolism0.67090656
97MP0001730_embryonic_growth_arrest0.66077401
98MP0009763_increased_sensitivity_to0.65312794
99MP0002138_abnormal_hepatobiliary_system0.64781988
100MP0003172_abnormal_lysosome_physiology0.60334402
101MP0002086_abnormal_extraembryonic_tissu0.59880783
102MP0003984_embryonic_growth_retardation0.59550020
103MP0005023_abnormal_wound_healing0.58853920
104MP0002088_abnormal_embryonic_growth/wei0.57651049
105MP0004147_increased_porphyrin_level0.57610429
106MP0005380_embryogenesis_phenotype0.57398020
107MP0001672_abnormal_embryogenesis/_devel0.57398020
108MP0006292_abnormal_olfactory_placode0.57182595
109MP0002075_abnormal_coat/hair_pigmentati0.55197363
110MP0005621_abnormal_cell_physiology0.55158912
111MP0004510_myositis0.54987363
112MP0005376_homeostasis/metabolism_phenot0.54750304
113MP0000477_abnormal_intestine_morphology0.52945800
114MP0002998_abnormal_bone_remodeling0.52285334
115MP0004197_abnormal_fetal_growth/weight/0.52067737
116MP0002080_prenatal_lethality0.49650363
117MP0002083_premature_death0.48846381
118MP0001663_abnormal_digestive_system0.48193706
119MP0001119_abnormal_female_reproductive0.47616667
120MP0002210_abnormal_sex_determination0.47507464
121MP0008873_increased_physiological_sensi0.47252630
122MP0001145_abnormal_male_reproductive0.45890635
123MP0003221_abnormal_cardiomyocyte_apopto0.45696096

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.22899285
2Recurrent viral infections (HP:0004429)4.10487182
3T lymphocytopenia (HP:0005403)4.04937147
4IgM deficiency (HP:0002850)4.03582906
5Abnormality of T cell number (HP:0011839)3.93519761
6Recurrent bronchitis (HP:0002837)3.89503074
7Recurrent fungal infections (HP:0002841)3.75285371
8Panhypogammaglobulinemia (HP:0003139)3.63560691
9Agammaglobulinemia (HP:0004432)3.55410517
10B lymphocytopenia (HP:0010976)3.53033763
11Abnormality of B cell number (HP:0010975)3.53033763
12Recurrent abscess formation (HP:0002722)3.48752473
13Abnormality of T cells (HP:0002843)3.33440101
14Thyroiditis (HP:0100646)3.22224060
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.22082545
16Recurrent bacterial skin infections (HP:0005406)3.21790242
17Meningitis (HP:0001287)3.21545292
18Myositis (HP:0100614)3.16388877
19Eczematoid dermatitis (HP:0000976)3.16089965
20Volvulus (HP:0002580)3.12395384
21Eosinophilia (HP:0001880)3.04656099
22Chronic otitis media (HP:0000389)3.03870322
23Severe combined immunodeficiency (HP:0004430)3.03637053
24Elevated erythrocyte sedimentation rate (HP:0003565)3.01650450
25Cellulitis (HP:0100658)2.98586429
26Acute lymphatic leukemia (HP:0006721)2.96589275
27Chronic mucocutaneous candidiasis (HP:0002728)2.91618255
28Recurrent cutaneous fungal infections (HP:0011370)2.91618255
29Combined immunodeficiency (HP:0005387)2.86560698
30Lymphopenia (HP:0001888)2.84848844
31Chromsome breakage (HP:0040012)2.84519507
32Thrombocytosis (HP:0001894)2.83396916
33IgG deficiency (HP:0004315)2.82434053
34Nasal polyposis (HP:0100582)2.82292515
35Recurrent sinusitis (HP:0011108)2.81803833
36Inflammation of the large intestine (HP:0002037)2.81538026
37Mediastinal lymphadenopathy (HP:0100721)2.80599641
38Abnormality of cells of the lymphoid lineage (HP:0012140)2.79569530
39Chronic diarrhea (HP:0002028)2.78967593
40Abnormality of eosinophils (HP:0001879)2.75653248
41IgA deficiency (HP:0002720)2.75199773
42Vasculitis (HP:0002633)2.73738404
43Granulocytopenia (HP:0001913)2.72585213
44Lymphoma (HP:0002665)2.70310823
45Gastrointestinal inflammation (HP:0004386)2.69223007
46Acute myeloid leukemia (HP:0004808)2.67536153
47Abnormality of T cell physiology (HP:0011840)2.67274819
48Viral hepatitis (HP:0006562)2.65832532
49Leukocytosis (HP:0001974)2.57947105
50Colitis (HP:0002583)2.57685411
51Chronic obstructive pulmonary disease (HP:0006510)2.57412004
52Obstructive lung disease (HP:0006536)2.57412004
53Abnormality of the prostate (HP:0008775)2.57046618
54Recurrent skin infections (HP:0001581)2.53950063
55Autoimmune thrombocytopenia (HP:0001973)2.49989895
56Optic neuritis (HP:0100653)2.49552606
57Retrobulbar optic neuritis (HP:0100654)2.49552606
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47449807
59Gastrointestinal infarctions (HP:0005244)2.47042207
60Hypoplasia of the thymus (HP:0000778)2.46022005
61Gastrointestinal stroma tumor (HP:0100723)2.45828220
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.45382195
63Absent/shortened dynein arms (HP:0200106)2.45382195
64Periodontitis (HP:0000704)2.41137799
65Stomach cancer (HP:0012126)2.40431578
66Pustule (HP:0200039)2.40309507
67Chronic sinusitis (HP:0011109)2.35139871
68Bronchitis (HP:0012387)2.34551148
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33409262
70Verrucae (HP:0200043)2.33110189
71Papilloma (HP:0012740)2.33110189
72Tubulointerstitial nephritis (HP:0001970)2.32391596
73Prominent nose (HP:0000448)2.31242692
74Prolonged bleeding time (HP:0003010)2.27444275
75Orchitis (HP:0100796)2.25284730
76Osteomyelitis (HP:0002754)2.25106013
77Abnormality of chromosome stability (HP:0003220)2.24724526
78Encephalitis (HP:0002383)2.23871891
79Abnormality of the nasal mucosa (HP:0000433)2.23668230
80Autoimmune hemolytic anemia (HP:0001890)2.22496895
81Myelodysplasia (HP:0002863)2.20359490
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19881365
83Amaurosis fugax (HP:0100576)2.14410526
84Neoplasm of the tracheobronchial system (HP:0100552)2.12008813
85Pulmonary infiltrates (HP:0002113)2.11852083
86Aplasia/Hypoplasia of the thymus (HP:0010515)2.11270499
87Long eyelashes (HP:0000527)2.11192314
88Abnormality of male internal genitalia (HP:0000022)2.10236261
89Recurrent pneumonia (HP:0006532)2.10101827
90Increased IgE level (HP:0003212)2.10061118
91Spontaneous hematomas (HP:0007420)2.09013335
92Ectopic kidney (HP:0000086)2.08970724
93Abnormality of the pleura (HP:0002103)2.07001814
94Basal cell carcinoma (HP:0002671)2.06885428
95Abnormality of DNA repair (HP:0003254)2.02402433
96Absent frontal sinuses (HP:0002688)2.02216939
97Keratoconjunctivitis sicca (HP:0001097)1.98950319
98Recurrent otitis media (HP:0000403)1.98782509
99Leukopenia (HP:0001882)1.97941063
100Recurrent gram-negative bacterial infections (HP:0005420)1.96129608
101Acute hepatic failure (HP:0006554)1.94925093
102Abnormal respiratory motile cilium morphology (HP:0005938)1.93798340
103Abnormal respiratory epithelium morphology (HP:0012253)1.93798340
104Stomatitis (HP:0010280)1.93071389
105Hemoptysis (HP:0002105)1.93040880
106Arterial thrombosis (HP:0004420)1.91942506
107Bronchiectasis (HP:0002110)1.91290480
108Neutropenia (HP:0001875)1.91192148
109Abnormal platelet volume (HP:0011876)1.89550534
110Sepsis (HP:0100806)1.89516221
111Epistaxis (HP:0000421)1.88797115
112Alveolar cell carcinoma (HP:0006519)1.88650305
113Prostate neoplasm (HP:0100787)1.88389305
114Agnosia (HP:0010524)1.88385296
115Clubbing of toes (HP:0100760)1.87650057
116Recurrent lower respiratory tract infections (HP:0002783)1.87027393
117Spinal cord lesions (HP:0100561)1.85732376
118Syringomyelia (HP:0003396)1.85732376
119High pitched voice (HP:0001620)1.85477869
120Chest pain (HP:0100749)1.85074783
121Abnormal respiratory motile cilium physiology (HP:0012261)1.84178313
122Keratoconjunctivitis (HP:0001096)1.83825622
123Abnormal ciliary motility (HP:0012262)1.83139465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.79203206
2TXK3.55742589
3CDK122.44914232
4MAP3K142.44838293
5STK102.33558758
6CDC72.29016659
7JAK32.17474710
8MAP3K102.15977793
9TYK22.02542833
10ZAP701.99389132
11ITK1.99060890
12IRAK41.98818163
13EEF2K1.97595830
14BLK1.94175185
15BTK1.89731813
16NEK21.89076330
17KIT1.80648706
18TEC1.77985184
19FRK1.74023109
20BMPR21.67338546
21GRK61.64167316
22CLK11.64026632
23BRD41.60268347
24CSF1R1.59035572
25IKBKE1.53208874
26JAK11.45911740
27STK41.45876464
28SYK1.43696487
29CSK1.37574027
30LCK1.35164371
31PIM11.32704928
32ATR1.30402376
33SIK21.26123608
34MAP3K131.24965695
35CDK41.21507570
36FGFR31.21103155
37IKBKB1.20638541
38IRAK11.19144401
39NEK91.17736307
40HCK1.15299698
41FGFR41.15132056
42IRAK31.14479650
43TBK11.11936516
44TAOK31.08837887
45CHUK1.08822305
46EPHA31.07272418
47CDK61.06844243
48FLT31.04032390
49SRPK11.02766811
50LYN1.02213937
51RPS6KA40.96771686
52TGFBR20.93656870
53NUAK10.90144411
54SGK20.85414882
55EIF2AK30.84115177
56BRSK20.83785102
57WNK10.83551543
58PASK0.83321793
59TRPM70.82654708
60PNCK0.80977571
61NLK0.79541453
62CAMK1D0.79202504
63LRRK20.79127609
64STK30.78490508
65MAP4K20.77957620
66CDK90.77932435
67AURKB0.77674110
68PRKCQ0.74566144
69MARK30.73849695
70PIK3CG0.73647856
71VRK10.73636254
72EPHB10.72583464
73CHEK10.71647121
74MKNK10.71065269
75ATM0.70841890
76MAP2K30.70272583
77CAMK1G0.69718668
78PKN20.68128586
79RPS6KB20.68055246
80MATK0.67894870
81CDK30.62506167
82TNK20.61697590
83PTK2B0.61571012
84ERN10.61481993
85MAPK150.60919615
86CDK70.60191194
87YES10.59173163
88TTK0.59030363
89RIPK40.58410033
90JAK20.58121714
91FES0.58044599
92MAPK130.57413836
93TLK10.57152925
94PTK60.56872603
95MKNK20.54104770
96WEE10.53790735
97MAP3K80.53300234
98FGR0.50461568
99PRPF4B0.50281777
100PLK10.49185748
101MELK0.49171898
102MAP3K70.48571628
103RPS6KA50.46863981
104MAPK110.46629394
105CDK190.45376080
106CHEK20.43792990
107PLK40.43691461
108CDK20.43613879
109CCNB10.43582858
110SGK30.43350600
111TTN0.41945618
112STK240.41753341
113DYRK30.41530244
114MST40.40754667
115RPS6KA60.40712440
116ZAK0.40651217
117MAPK70.39943338
118EIF2AK20.38895169
119HIPK20.38507509
120PDK10.33072925
121MAPK120.32729313
122RAF10.30280286
123MAP3K60.28270281
124RET0.27487686

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.79971577
2DNA replication_Homo sapiens_hsa030302.61634411
3Non-homologous end-joining_Homo sapiens_hsa034502.56977437
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.38737526
5Mismatch repair_Homo sapiens_hsa034302.36987087
6B cell receptor signaling pathway_Homo sapiens_hsa046622.36394550
7Base excision repair_Homo sapiens_hsa034102.21785686
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.21123676
9Measles_Homo sapiens_hsa051622.13680938
10Antigen processing and presentation_Homo sapiens_hsa046122.08386784
11T cell receptor signaling pathway_Homo sapiens_hsa046602.03843415
12Fanconi anemia pathway_Homo sapiens_hsa034601.90455154
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89588309
14Homologous recombination_Homo sapiens_hsa034401.86713010
15Leishmaniasis_Homo sapiens_hsa051401.86511127
16Hematopoietic cell lineage_Homo sapiens_hsa046401.84617731
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84467132
18Herpes simplex infection_Homo sapiens_hsa051681.80826753
19Osteoclast differentiation_Homo sapiens_hsa043801.73375738
20Graft-versus-host disease_Homo sapiens_hsa053321.63972714
21Allograft rejection_Homo sapiens_hsa053301.62656580
22Cell cycle_Homo sapiens_hsa041101.54759885
23Spliceosome_Homo sapiens_hsa030401.53167177
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50738190
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41166589
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39891571
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37982471
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.37529449
29Nucleotide excision repair_Homo sapiens_hsa034201.31148453
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30685802
31Acute myeloid leukemia_Homo sapiens_hsa052211.28494720
32Influenza A_Homo sapiens_hsa051641.27404281
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26467817
34Toxoplasmosis_Homo sapiens_hsa051451.25377085
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25210535
36Viral carcinogenesis_Homo sapiens_hsa052031.23505970
37Hepatitis B_Homo sapiens_hsa051611.23350863
38Systemic lupus erythematosus_Homo sapiens_hsa053221.18997063
39Viral myocarditis_Homo sapiens_hsa054161.18765414
40Epstein-Barr virus infection_Homo sapiens_hsa051691.16307374
41mRNA surveillance pathway_Homo sapiens_hsa030151.14403690
42Apoptosis_Homo sapiens_hsa042101.14099356
43Chronic myeloid leukemia_Homo sapiens_hsa052201.13687992
44RNA degradation_Homo sapiens_hsa030181.12998786
45HTLV-I infection_Homo sapiens_hsa051661.10617780
46One carbon pool by folate_Homo sapiens_hsa006701.09957840
47Autoimmune thyroid disease_Homo sapiens_hsa053201.07854986
48RNA transport_Homo sapiens_hsa030131.06453550
49Small cell lung cancer_Homo sapiens_hsa052221.06050174
50TNF signaling pathway_Homo sapiens_hsa046681.04034434
51Chemokine signaling pathway_Homo sapiens_hsa040621.03863238
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02585619
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.02325113
54Lysine degradation_Homo sapiens_hsa003101.02265287
55p53 signaling pathway_Homo sapiens_hsa041151.02218289
56Pancreatic cancer_Homo sapiens_hsa052120.94035077
57Legionellosis_Homo sapiens_hsa051340.92399424
58Rheumatoid arthritis_Homo sapiens_hsa053230.91745050
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91171897
60Platelet activation_Homo sapiens_hsa046110.90435822
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85780617
62Asthma_Homo sapiens_hsa053100.85085038
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82956694
64Basal transcription factors_Homo sapiens_hsa030220.80875150
65Tuberculosis_Homo sapiens_hsa051520.79964963
66Non-small cell lung cancer_Homo sapiens_hsa052230.79800617
67MicroRNAs in cancer_Homo sapiens_hsa052060.79295012
68Staphylococcus aureus infection_Homo sapiens_hsa051500.77647271
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76489416
70Ribosome_Homo sapiens_hsa030100.76177287
71Shigellosis_Homo sapiens_hsa051310.76120660
72Dorso-ventral axis formation_Homo sapiens_hsa043200.74383643
73Notch signaling pathway_Homo sapiens_hsa043300.74329746
74Malaria_Homo sapiens_hsa051440.72947927
75Hepatitis C_Homo sapiens_hsa051600.69484032
76Colorectal cancer_Homo sapiens_hsa052100.67984446
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65905595
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63551400
79Pertussis_Homo sapiens_hsa051330.62791243
80Regulation of autophagy_Homo sapiens_hsa041400.62633558
81Prostate cancer_Homo sapiens_hsa052150.59794029
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58839391
83African trypanosomiasis_Homo sapiens_hsa051430.55404538
84Pyrimidine metabolism_Homo sapiens_hsa002400.55174909
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52712051
86Prolactin signaling pathway_Homo sapiens_hsa049170.51256783
87Other glycan degradation_Homo sapiens_hsa005110.49792690
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49378011
89FoxO signaling pathway_Homo sapiens_hsa040680.49013760
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.48464496
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47951928
92Salmonella infection_Homo sapiens_hsa051320.45349364
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42805727
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41320330
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40892639
96Pathways in cancer_Homo sapiens_hsa052000.40763283
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.38448177
98ABC transporters_Homo sapiens_hsa020100.37887772
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37366571
100Choline metabolism in cancer_Homo sapiens_hsa052310.37333466
101Olfactory transduction_Homo sapiens_hsa047400.36097017
102Phototransduction_Homo sapiens_hsa047440.34535716
103Type I diabetes mellitus_Homo sapiens_hsa049400.34124523
104Caffeine metabolism_Homo sapiens_hsa002320.32110526
105Endometrial cancer_Homo sapiens_hsa052130.31892861
106Inositol phosphate metabolism_Homo sapiens_hsa005620.31816192
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31057579
108Phagosome_Homo sapiens_hsa041450.29611656
109Insulin resistance_Homo sapiens_hsa049310.29330308
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29122831
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29044634
112mTOR signaling pathway_Homo sapiens_hsa041500.29010901
113HIF-1 signaling pathway_Homo sapiens_hsa040660.28685853
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28475683
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26218499
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.22376323
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20008179
118Alcoholism_Homo sapiens_hsa050340.19815919
119VEGF signaling pathway_Homo sapiens_hsa043700.18803721

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