CNTN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.62887942
2synaptic vesicle exocytosis (GO:0016079)5.33858536
3vocalization behavior (GO:0071625)5.29486019
4neurotransmitter-gated ion channel clustering (GO:0072578)5.12202562
5neuron cell-cell adhesion (GO:0007158)5.09825545
6G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.99586958
7protein localization to synapse (GO:0035418)4.98720391
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97892336
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90033644
10positive regulation of synapse maturation (GO:0090129)4.82430133
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.77613528
12negative regulation of cytosolic calcium ion concentration (GO:0051481)4.65800823
13gamma-aminobutyric acid signaling pathway (GO:0007214)4.64925936
14regulation of synaptic vesicle exocytosis (GO:2000300)4.63069513
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.62656388
16glutamate receptor signaling pathway (GO:0007215)4.59235672
17negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.56738254
18response to histamine (GO:0034776)4.55952614
19glutamate secretion (GO:0014047)4.50573442
20regulation of glutamate receptor signaling pathway (GO:1900449)4.45903842
21regulation of synapse structural plasticity (GO:0051823)4.42526022
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.36344580
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.33896264
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32195587
25neuron-neuron synaptic transmission (GO:0007270)4.31172014
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.29374922
27synaptic vesicle maturation (GO:0016188)4.24410664
28presynaptic membrane assembly (GO:0097105)4.23633491
29neurotransmitter secretion (GO:0007269)4.22951834
30synaptic transmission, glutamatergic (GO:0035249)4.07631958
31regulation of synaptic transmission, glutamatergic (GO:0051966)4.06895256
32regulation of synaptic vesicle transport (GO:1902803)4.01141552
33regulation of synapse maturation (GO:0090128)4.00649829
34striatum development (GO:0021756)3.98420193
35postsynaptic membrane organization (GO:0001941)3.97264969
36nucleobase catabolic process (GO:0046113)3.89768523
37prepulse inhibition (GO:0060134)3.85909520
38cerebellar granule cell differentiation (GO:0021707)3.80845831
39synapse assembly (GO:0007416)3.73091882
40long-term synaptic potentiation (GO:0060291)3.72268791
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.70464326
42presynaptic membrane organization (GO:0097090)3.70294458
43neuron recognition (GO:0008038)3.69444616
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62793371
45synaptic vesicle endocytosis (GO:0048488)3.61396867
46locomotory exploration behavior (GO:0035641)3.61193875
47protein localization to cilium (GO:0061512)3.59497301
48neurotransmitter transport (GO:0006836)3.58470622
49regulation of postsynaptic membrane potential (GO:0060078)3.52846360
50neuronal action potential propagation (GO:0019227)3.52415552
51membrane depolarization during action potential (GO:0086010)3.51833076
52cerebellar Purkinje cell differentiation (GO:0021702)3.50748330
53behavioral response to cocaine (GO:0048148)3.47456649
54exploration behavior (GO:0035640)3.45921270
55regulation of neurotransmitter secretion (GO:0046928)3.43425335
56proline transport (GO:0015824)3.43008202
57retinal cone cell development (GO:0046549)3.42772253
58behavioral defense response (GO:0002209)3.41222354
59behavioral fear response (GO:0001662)3.41222354
60regulation of neuronal synaptic plasticity (GO:0048168)3.40674329
61parturition (GO:0007567)3.40600383
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38524876
63innervation (GO:0060384)3.38390736
64cell migration in hindbrain (GO:0021535)3.37914214
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.37129083
66auditory behavior (GO:0031223)3.36784615
67mating behavior (GO:0007617)3.36441208
68dendritic spine morphogenesis (GO:0060997)3.36384870
69sodium ion export (GO:0071436)3.35539287
70regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.34957656
71regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.34957656
72positive regulation of membrane potential (GO:0045838)3.34330562
73long-term memory (GO:0007616)3.33951045
74membrane hyperpolarization (GO:0060081)3.32622063
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31603429
76negative regulation of dendrite development (GO:2000171)3.30869178
77cellular potassium ion homeostasis (GO:0030007)3.28907394
78layer formation in cerebral cortex (GO:0021819)3.28665427
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28293231
80regulation of neurotransmitter transport (GO:0051588)3.28101272
81detection of calcium ion (GO:0005513)3.19924720
82detection of light stimulus involved in visual perception (GO:0050908)3.19802230
83detection of light stimulus involved in sensory perception (GO:0050962)3.19802230
84gamma-aminobutyric acid transport (GO:0015812)3.19550861
85membrane depolarization (GO:0051899)3.18583460
86dopamine biosynthetic process (GO:0042416)3.18462318
87cell communication by electrical coupling (GO:0010644)3.17892034
88mechanosensory behavior (GO:0007638)3.17260165
89fear response (GO:0042596)3.16360551
90startle response (GO:0001964)3.16226980
91pyrimidine nucleobase catabolic process (GO:0006208)3.15113894
92regulation of vesicle fusion (GO:0031338)3.14929911
93synaptic transmission (GO:0007268)3.14096876
94positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12308704
95response to auditory stimulus (GO:0010996)3.10583668
96regulation of neurotransmitter levels (GO:0001505)3.10419048
97positive regulation of neurotransmitter transport (GO:0051590)3.09398136
98righting reflex (GO:0060013)3.08484781
99relaxation of smooth muscle (GO:0044557)3.08108037
100axonal fasciculation (GO:0007413)3.07965480
101dendrite morphogenesis (GO:0048813)3.05311961
102positive regulation of dendritic spine morphogenesis (GO:0061003)3.03420663
103transmission of nerve impulse (GO:0019226)3.02184152
104learning (GO:0007612)3.01212129
105retinal ganglion cell axon guidance (GO:0031290)3.01111842
106positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.99731638
107negative regulation of hormone biosynthetic process (GO:0032353)2.99359667
108neuronal action potential (GO:0019228)2.98900706
109regulation of synaptic plasticity (GO:0048167)2.98847508
110synaptic vesicle transport (GO:0048489)2.98338154
111establishment of synaptic vesicle localization (GO:0097480)2.98338154
112regulation of glutamate secretion (GO:0014048)2.98032106
113response to pheromone (GO:0019236)2.97922253
114synapse organization (GO:0050808)2.95860345
115regulation of hexokinase activity (GO:1903299)2.95624418
116regulation of glucokinase activity (GO:0033131)2.95624418
117serotonin metabolic process (GO:0042428)2.85190740
118negative regulation of dendrite morphogenesis (GO:0050774)2.81810332
119nerve growth factor signaling pathway (GO:0038180)2.80513240
120central nervous system neuron axonogenesis (GO:0021955)2.79451219
121behavioral response to nicotine (GO:0035095)2.79073557
122insulin secretion (GO:0030073)2.76793763
123regulation of cAMP-dependent protein kinase activity (GO:2000479)2.76075906
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74861791
125negative regulation of heart rate (GO:0010459)2.63640204
126regulation of calcium ion-dependent exocytosis (GO:0017158)2.62619015
127central nervous system projection neuron axonogenesis (GO:0021952)2.61989582
128inositol phosphate catabolic process (GO:0071545)2.60971615
129adult behavior (GO:0030534)2.58936719
130regulation of respiratory gaseous exchange (GO:0043576)2.58391119
131neurofilament cytoskeleton organization (GO:0060052)2.54894913
132reflex (GO:0060004)2.54286951
133regulation of voltage-gated calcium channel activity (GO:1901385)2.52447808
134estrogen biosynthetic process (GO:0006703)2.52012472
135adaptation of signaling pathway (GO:0023058)2.51251632
136female gonad development (GO:0008585)2.49577063
137negative regulation of hormone metabolic process (GO:0032351)2.49273468
138primary amino compound metabolic process (GO:1901160)2.49096835
139vascular smooth muscle contraction (GO:0014829)2.48752976
140regulation of respiratory system process (GO:0044065)2.47662470
141C4-dicarboxylate transport (GO:0015740)2.47442536
142regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46032360
143tachykinin receptor signaling pathway (GO:0007217)2.42446691
144cilium or flagellum-dependent cell motility (GO:0001539)2.40533597
145regulation of neurotransmitter uptake (GO:0051580)2.38871322
146L-fucose metabolic process (GO:0042354)2.38499534
147L-fucose catabolic process (GO:0042355)2.38499534
148fucose catabolic process (GO:0019317)2.38499534
149cilium movement (GO:0003341)2.38218245
150regulation of action potential (GO:0098900)2.37827965
151adult locomotory behavior (GO:0008344)2.37251877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.72805145
2GBX2_23144817_ChIP-Seq_PC3_Human4.64524259
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09745387
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05292777
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92765699
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92458720
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89769267
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85902009
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.65959340
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.61990779
11TAF15_26573619_Chip-Seq_HEK293_Human2.53640257
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50414941
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48202238
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45626463
15* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40051376
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38707485
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31988766
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31378709
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31378709
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27519502
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27046254
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23537535
23* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20156729
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19112990
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.15918326
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.14450820
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13617387
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13160000
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11467524
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.11418529
31DROSHA_22980978_ChIP-Seq_HELA_Human2.05697039
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.05452373
33RARB_27405468_Chip-Seq_BRAIN_Mouse2.03683545
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03357410
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97622101
36AR_21572438_ChIP-Seq_LNCaP_Human1.89485916
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.86727588
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84040215
39* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81846250
40IGF1R_20145208_ChIP-Seq_DFB_Human1.79289297
41* P300_19829295_ChIP-Seq_ESCs_Human1.76013893
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.72627844
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68360050
44* FUS_26573619_Chip-Seq_HEK293_Human1.66670425
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63214712
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.55124578
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.54079088
48BCAT_22108803_ChIP-Seq_LS180_Human1.49626677
49RNF2_27304074_Chip-Seq_NSC_Mouse1.49319084
50AR_25329375_ChIP-Seq_VCAP_Human1.48197391
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45940830
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43909747
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42660087
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41098970
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.38841156
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35571127
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34074733
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33296237
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33130371
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31549512
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.31063624
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30350723
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30246930
64ER_23166858_ChIP-Seq_MCF-7_Human1.28936727
65* STAT3_23295773_ChIP-Seq_U87_Human1.26661589
66ZNF274_21170338_ChIP-Seq_K562_Hela1.26133472
67* TCF4_23295773_ChIP-Seq_U87_Human1.25438387
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24354766
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21509246
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19173530
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.18341528
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17830270
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16445250
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16235917
75P53_22387025_ChIP-Seq_ESCs_Mouse1.15590713
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15279627
77* TAL1_26923725_Chip-Seq_HPCs_Mouse1.14361996
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14276423
79* AR_19668381_ChIP-Seq_PC3_Human1.14258244
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.14152129
81AHR_22903824_ChIP-Seq_MCF-7_Human1.13132426
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12553488
83VDR_22108803_ChIP-Seq_LS180_Human1.12028438
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11224430
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11085947
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.10833687
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10635603
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10566391
89RUNX2_22187159_ChIP-Seq_PCA_Human1.10363602
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09961935
91JUN_21703547_ChIP-Seq_K562_Human1.09931899
92TCF4_22108803_ChIP-Seq_LS180_Human1.09543162
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.06418689
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.06327311
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05744418
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04972650
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.04011480
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03388995
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.02943681
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01879608
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00821525
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.00067542
103KDM2B_26808549_Chip-Seq_REH_Human0.99280022
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98891989
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97942903
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97730199
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97719057
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97719057
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97081137
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.96744404
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96682913
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.94817753
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94653079
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93788047
115SOX9_26525672_Chip-Seq_HEART_Mouse0.93492493
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93392384
117* CBP_20019798_ChIP-Seq_JUKART_Human0.93038384
118* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93038384
119EWS_26573619_Chip-Seq_HEK293_Human0.92994165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.99715039
2MP0003880_abnormal_central_pattern4.51936874
3MP0003635_abnormal_synaptic_transmissio3.86722755
4MP0002822_catalepsy3.83583066
5MP0009745_abnormal_behavioral_response3.38867349
6MP0002063_abnormal_learning/memory/cond3.25712914
7MP0009046_muscle_twitch3.09832661
8* MP0002064_seizures3.03674487
9MP0004270_analgesia2.95572963
10MP0002572_abnormal_emotion/affect_behav2.83661577
11MP0001968_abnormal_touch/_nociception2.74118898
12MP0002272_abnormal_nervous_system2.53283844
13MP0001486_abnormal_startle_reflex2.41579010
14MP0002734_abnormal_mechanical_nocicepti2.37803657
15MP0001501_abnormal_sleep_pattern2.30895570
16MP0002735_abnormal_chemical_nociception2.26109287
17MP0005551_abnormal_eye_electrophysiolog2.25077271
18MP0002736_abnormal_nociception_after2.23188981
19MP0001188_hyperpigmentation2.18032287
20MP0002067_abnormal_sensory_capabilities2.17975013
21MP0001529_abnormal_vocalization2.17378112
22MP0001440_abnormal_grooming_behavior2.11757233
23MP0005423_abnormal_somatic_nervous2.10316213
24MP0002184_abnormal_innervation2.02230126
25MP0001984_abnormal_olfaction1.98366020
26MP0005386_behavior/neurological_phenoty1.87616158
27MP0004924_abnormal_behavior1.87616158
28MP0000778_abnormal_nervous_system1.85150144
29MP0006276_abnormal_autonomic_nervous1.84842971
30MP0003787_abnormal_imprinting1.81764550
31MP0002557_abnormal_social/conspecific_i1.78675260
32MP0003879_abnormal_hair_cell1.78503466
33MP0005646_abnormal_pituitary_gland1.77897986
34MP0001502_abnormal_circadian_rhythm1.77305874
35MP0002733_abnormal_thermal_nociception1.76964963
36MP0001970_abnormal_pain_threshold1.73634531
37MP0002090_abnormal_vision1.72742562
38MP0005187_abnormal_penis_morphology1.72626521
39MP0002102_abnormal_ear_morphology1.65029746
40MP0009780_abnormal_chondrocyte_physiolo1.60897735
41MP0004811_abnormal_neuron_physiology1.56637074
42MP0008569_lethality_at_weaning1.54398579
43MP0008057_abnormal_DNA_replication1.50597141
44MP0003329_amyloid_beta_deposits1.47493797
45MP0000955_abnormal_spinal_cord1.47336216
46MP0006072_abnormal_retinal_apoptosis1.45900939
47MP0001905_abnormal_dopamine_level1.45347575
48MP0002882_abnormal_neuron_morphology1.44342377
49MP0004142_abnormal_muscle_tone1.37871674
50MP0002909_abnormal_adrenal_gland1.37291903
51MP0002066_abnormal_motor_capabilities/c1.33866359
52MP0000751_myopathy1.31396247
53MP0003122_maternal_imprinting1.29825069
54MP0005379_endocrine/exocrine_gland_phen1.24694777
55MP0010234_abnormal_vibrissa_follicle1.24347106
56MP0010386_abnormal_urinary_bladder1.23131446
57MP0004233_abnormal_muscle_weight1.17754835
58MP0004215_abnormal_myocardial_fiber1.17039890
59MP0006292_abnormal_olfactory_placode1.16442739
60MP0000639_abnormal_adrenal_gland1.15038840
61MP0002229_neurodegeneration1.12505399
62MP0000631_abnormal_neuroendocrine_gland1.12047584
63MP0004085_abnormal_heartbeat1.10795212
64MP0005248_abnormal_Harderian_gland1.10731077
65MP0004858_abnormal_nervous_system1.09819793
66MP0003633_abnormal_nervous_system1.09460275
67MP0001944_abnormal_pancreas_morphology1.08884178
68MP0003195_calcinosis1.08705101
69MP0002152_abnormal_brain_morphology1.08017245
70MP0004742_abnormal_vestibular_system1.07497861
71MP0005253_abnormal_eye_physiology1.06309334
72MP0002837_dystrophic_cardiac_calcinosis1.06134947
73MP0002752_abnormal_somatic_nervous1.05733873
74MP0000427_abnormal_hair_cycle1.01847716
75MP0002693_abnormal_pancreas_physiology1.00391721
76MP0004145_abnormal_muscle_electrophysio1.00257872
77MP0005389_reproductive_system_phenotype0.99779315
78MP0004885_abnormal_endolymph0.98881075
79MP0005220_abnormal_exocrine_pancreas0.98588380
80MP0003631_nervous_system_phenotype0.98292318
81MP0001919_abnormal_reproductive_system0.97331223
82MP0002876_abnormal_thyroid_physiology0.94925842
83MP0002069_abnormal_eating/drinking_beha0.93753407
84MP0006035_abnormal_mitochondrial_morpho0.92317367
85MP0002638_abnormal_pupillary_reflex0.91044141
86MP0008872_abnormal_physiological_respon0.90558133
87MP0001963_abnormal_hearing_physiology0.90071982
88MP0003137_abnormal_impulse_conducting0.89354451
89MP0005394_taste/olfaction_phenotype0.88867258
90MP0005499_abnormal_olfactory_system0.88867258
91MP0004510_myositis0.88430282
92MP0005645_abnormal_hypothalamus_physiol0.88065633
93MP0004043_abnormal_pH_regulation0.87423117
94MP0008995_early_reproductive_senescence0.85926369
95MP0000462_abnormal_digestive_system0.84951321
96MP0004036_abnormal_muscle_relaxation0.84749177
97MP0001485_abnormal_pinna_reflex0.83972576
98MP0005409_darkened_coat_color0.82787571
99MP0003283_abnormal_digestive_organ0.82511573
100MP0005195_abnormal_posterior_eye0.81580708
101MP0000538_abnormal_urinary_bladder0.81473570
102MP0002160_abnormal_reproductive_system0.79820313
103MP0010678_abnormal_skin_adnexa0.79523670
104MP0003953_abnormal_hormone_level0.78295397
105MP0001986_abnormal_taste_sensitivity0.76698280
106MP0002163_abnormal_gland_morphology0.76194358
107MP0003890_abnormal_embryonic-extraembry0.76160659
108MP0000569_abnormal_digit_pigmentation0.75706279
109MP0002751_abnormal_autonomic_nervous0.74336008
110MP0000647_abnormal_sebaceous_gland0.74323068
111MP0005535_abnormal_body_temperature0.69485478
112MP0003634_abnormal_glial_cell0.69451608
113MP0002332_abnormal_exercise_endurance0.69075052
114MP0004084_abnormal_cardiac_muscle0.67119992
115MP0003121_genomic_imprinting0.66297209
116MP0000026_abnormal_inner_ear0.65975546
117MP0001346_abnormal_lacrimal_gland0.65680318
118MP0003632_abnormal_nervous_system0.65675059
119MP0008874_decreased_physiological_sensi0.63303039
120MP0001177_atelectasis0.62987340
121MP0000013_abnormal_adipose_tissue0.62254797
122MP0002234_abnormal_pharynx_morphology0.61863587
123MP0001664_abnormal_digestion0.60204958
124MP0005620_abnormal_muscle_contractility0.59594853
125MP0008877_abnormal_DNA_methylation0.58161133
126MP0000604_amyloidosis0.56819614
127MP0003861_abnormal_nervous_system0.55246422

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.65813576
2Epileptic encephalopathy (HP:0200134)5.90337743
3Febrile seizures (HP:0002373)5.54251561
4Congenital stationary night blindness (HP:0007642)5.14081232
5Myokymia (HP:0002411)5.00250633
6Focal seizures (HP:0007359)4.90849988
7Atonic seizures (HP:0010819)4.81590182
8Absence seizures (HP:0002121)4.48545555
9Dialeptic seizures (HP:0011146)4.11407308
10Progressive cerebellar ataxia (HP:0002073)3.99280878
11Hyperventilation (HP:0002883)3.98253023
12Visual hallucinations (HP:0002367)3.62745096
13Broad-based gait (HP:0002136)3.51207305
14Generalized tonic-clonic seizures (HP:0002069)3.49986027
15Central scotoma (HP:0000603)3.22320637
16Hypoglycemic coma (HP:0001325)3.21385696
17Drooling (HP:0002307)3.19434168
18Excessive salivation (HP:0003781)3.19434168
19Limb dystonia (HP:0002451)3.13341394
20Mutism (HP:0002300)3.08783471
21Dysdiadochokinesis (HP:0002075)3.03125486
22Polyphagia (HP:0002591)2.99590560
23Intestinal atresia (HP:0011100)2.98826165
24Gait imbalance (HP:0002141)2.95230071
25Oligodactyly (hands) (HP:0001180)2.92433059
26Gaze-evoked nystagmus (HP:0000640)2.91532130
27Epileptiform EEG discharges (HP:0011182)2.90952106
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.88738265
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.88738265
30Truncal ataxia (HP:0002078)2.85641443
31Progressive inability to walk (HP:0002505)2.84791925
32EEG with generalized epileptiform discharges (HP:0011198)2.75623539
33Abnormality of the lower motor neuron (HP:0002366)2.75267433
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74854973
35Poor eye contact (HP:0000817)2.74584662
36Action tremor (HP:0002345)2.72550059
37Depression (HP:0000716)2.71472798
38Ankle clonus (HP:0011448)2.70112014
39Abnormal eating behavior (HP:0100738)2.69890644
40Amblyopia (HP:0000646)2.68757796
41Hypothermia (HP:0002045)2.67903705
42Protruding tongue (HP:0010808)2.64054470
43Congenital sensorineural hearing impairment (HP:0008527)2.63615690
44Hemiparesis (HP:0001269)2.63443534
45Inability to walk (HP:0002540)2.63060435
46Aqueductal stenosis (HP:0002410)2.62275654
47Agitation (HP:0000713)2.60567215
48Supranuclear gaze palsy (HP:0000605)2.58545411
49Abnormality of macular pigmentation (HP:0008002)2.58312688
50Pheochromocytoma (HP:0002666)2.57815139
51Abnormal social behavior (HP:0012433)2.56269424
52Impaired social interactions (HP:0000735)2.56269424
53Severe visual impairment (HP:0001141)2.55603747
54Torticollis (HP:0000473)2.54378565
55Ketoacidosis (HP:0001993)2.54030417
56Anxiety (HP:0000739)2.51658591
57Pancreatic fibrosis (HP:0100732)2.50803061
58Urinary bladder sphincter dysfunction (HP:0002839)2.46155889
59Fetal akinesia sequence (HP:0001989)2.44895634
60Nephronophthisis (HP:0000090)2.42851940
61Abnormal respiratory motile cilium physiology (HP:0012261)2.42729753
62Abnormal hair whorl (HP:0010721)2.42615643
63Hypsarrhythmia (HP:0002521)2.41015175
64Impaired vibration sensation in the lower limbs (HP:0002166)2.40222239
65Dysmetric saccades (HP:0000641)2.40073837
66Vaginal atresia (HP:0000148)2.37731240
67Congenital primary aphakia (HP:0007707)2.33160585
68Abnormal ciliary motility (HP:0012262)2.31507491
69Akinesia (HP:0002304)2.31471641
70Congenital malformation of the right heart (HP:0011723)2.31271068
71Double outlet right ventricle (HP:0001719)2.31271068
72Absent speech (HP:0001344)2.30520858
73Abnormality of binocular vision (HP:0011514)2.29704621
74Diplopia (HP:0000651)2.29704621
75Hypoglycemic seizures (HP:0002173)2.29635174
76Hyperinsulinemic hypoglycemia (HP:0000825)2.27968739
77Nephrogenic diabetes insipidus (HP:0009806)2.27029789
78Neuroendocrine neoplasm (HP:0100634)2.27002370
79Enlarged penis (HP:0000040)2.26856552
80Dysmetria (HP:0001310)2.26795898
81Bony spicule pigmentary retinopathy (HP:0007737)2.25587503
82Ulnar claw (HP:0001178)2.23445230
83Medial flaring of the eyebrow (HP:0010747)2.23351236
84Molar tooth sign on MRI (HP:0002419)2.22902031
85Abnormality of midbrain morphology (HP:0002418)2.22902031
86Genetic anticipation (HP:0003743)2.20323412
87Focal dystonia (HP:0004373)2.18611143
88Stereotypic behavior (HP:0000733)2.17408345
89Impaired smooth pursuit (HP:0007772)2.14589137
90Scanning speech (HP:0002168)2.13886632
91Pancreatic cysts (HP:0001737)2.13714459
92Decreased central vision (HP:0007663)2.13536591
93Attenuation of retinal blood vessels (HP:0007843)2.12643464
94Craniofacial dystonia (HP:0012179)2.11819769
95True hermaphroditism (HP:0010459)2.11739355
96Rhinitis (HP:0012384)2.10748971
97Progressive macrocephaly (HP:0004481)2.10445526
98Decreased circulating renin level (HP:0003351)2.10292984
99Bradykinesia (HP:0002067)2.09407859
100Hypoventilation (HP:0002791)2.09129385
101Spastic gait (HP:0002064)2.07829738
102Prolonged QT interval (HP:0001657)2.07813629
103Poor suck (HP:0002033)2.07710948
104Abnormal respiratory epithelium morphology (HP:0012253)2.07668384
105Abnormal respiratory motile cilium morphology (HP:0005938)2.07668384
106Chronic bronchitis (HP:0004469)2.07463074
107Blue irides (HP:0000635)2.05177699
108Termporal pattern (HP:0011008)2.04406996
109Insidious onset (HP:0003587)2.04406996
110Specific learning disability (HP:0001328)2.02757886
111Septo-optic dysplasia (HP:0100842)2.02090363
112Abnormality of salivation (HP:0100755)2.02047737
113Cholecystitis (HP:0001082)2.01692588
114Abnormal gallbladder physiology (HP:0012438)2.01692588
115Proximal tubulopathy (HP:0000114)2.01101557
116Exotropia (HP:0000577)1.98617489
117Abnormality of ocular smooth pursuit (HP:0000617)1.97399739
118Hyperthyroidism (HP:0000836)1.97002759
119Postural instability (HP:0002172)1.96253059
120Shoulder girdle muscle weakness (HP:0003547)1.96000834
121Scotoma (HP:0000575)1.95613804
122Hyperglycemia (HP:0003074)1.95529824
123Lissencephaly (HP:0001339)1.94633492
124Abnormality of the renal cortex (HP:0011035)1.94580528
125Renal cortical cysts (HP:0000803)1.94300506
126Amyotrophic lateral sclerosis (HP:0007354)1.94083647
127Oligodactyly (HP:0012165)1.92084892
128Abnormal EKG (HP:0003115)1.90949797
129Intention tremor (HP:0002080)1.90735396
130Absent/shortened dynein arms (HP:0200106)1.90480101
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.90480101
132Urinary urgency (HP:0000012)1.89464403
133Abnormality of vitamin B metabolism (HP:0004340)1.88990803
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.88977328
135Hypoplasia of the brainstem (HP:0002365)1.88977328
136Abnormality of the corticospinal tract (HP:0002492)1.88392466
137Muscular hypotonia of the trunk (HP:0008936)1.87300880
138Esotropia (HP:0000565)1.86826022
139Insulin-resistant diabetes mellitus (HP:0000831)1.86562208
140Incomplete penetrance (HP:0003829)1.84796538
141Abnormality of the labia minora (HP:0012880)1.83202169
142Impaired vibratory sensation (HP:0002495)1.83043079
143Tubulointerstitial nephritis (HP:0001970)1.82236205
144Poor coordination (HP:0002370)1.82177796
145Fair hair (HP:0002286)1.80867021
146Sleep apnea (HP:0010535)1.80780166
147Abnormality of the renal medulla (HP:0100957)1.80585290
148Open mouth (HP:0000194)1.80499674
149Genital tract atresia (HP:0001827)1.80463334
150Chronic hepatic failure (HP:0100626)1.77109001
151Renal hypoplasia (HP:0000089)1.72284655
152Syncope (HP:0001279)1.71106923
153Renal salt wasting (HP:0000127)1.69836932
154Short chin (HP:0000331)1.68785560
155Menstrual irregularities (HP:0000858)1.68326589
156Hypomagnesemia (HP:0002917)1.68135013
157Abnormality of the calf musculature (HP:0001430)1.67797916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.98637889
2CASK4.53618850
3MARK14.36479249
4NTRK34.33390579
5MAP3K93.46468058
6EPHA43.43475540
7TNIK3.02170267
8MAP3K42.96575935
9MAP2K72.82809119
10TRIM282.73199482
11FGFR22.36764414
12MINK12.30885937
13MAPK132.17310326
14NTRK22.15686110
15DAPK22.04020291
16MAP4K21.97556881
17DYRK31.79017339
18PINK11.77083713
19MAP3K121.76780872
20PLK21.71184340
21PAK61.55578939
22PHKG21.51286500
23PHKG11.51286500
24MAP2K41.49434832
25KSR11.48722026
26CCNB11.48465961
27PKN21.44575499
28BMPR1B1.44105204
29PRPF4B1.42934326
30OBSCN1.39454151
31AKT31.37701243
32DAPK11.37153209
33CDK51.36452433
34CSNK1G11.31258909
35SIK31.30924712
36GRK51.28656683
37ARAF1.23939151
38PRKCG1.18987566
39CDK191.16502682
40CAMK2A1.13212254
41CSNK1A1L1.08046091
42CAMKK11.04960897
43SIK21.00318870
44SGK2230.98238807
45SGK4940.98238807
46DYRK1A0.97320279
47NTRK10.97235381
48CAMKK20.96522483
49CDK180.96405831
50MKNK20.94785848
51RPS6KA40.94429445
52CSNK1G20.93868273
53DYRK20.92205425
54UHMK10.91796873
55CDK140.89526597
56CDK150.89255760
57CAMK2B0.88925993
58FES0.88707363
59ERBB30.86870498
60MST40.84184041
61NME10.82731717
62SGK20.82401695
63PRKCE0.81466108
64KSR20.81404783
65OXSR10.80784592
66FLT30.80684972
67BRAF0.80192351
68FGFR30.79388280
69STK390.78046084
70TSSK60.77460230
71CDK11A0.77303319
72MAP3K130.74663219
73PNCK0.72642680
74CAMK10.70368067
75GRK70.69166958
76MARK20.68952189
77STK38L0.68934507
78BCR0.67482817
79TAOK30.64996873
80NEK10.64701397
81STK380.64011969
82PKN10.63882675
83CDK80.62844064
84NLK0.62385240
85SGK10.61612237
86WNK30.61274791
87CAMK2D0.60544657
88PDK30.60182504
89PDK40.60182504
90PTK2B0.59379007
91MAPK120.59038901
92FER0.58155143
93GRK10.57938025
94CAMK1G0.57831334
95CSNK1D0.57757603
96MAP3K60.54983242
97LATS20.53753316
98PAK30.53398179
99MUSK0.53202760
100STK110.51970741
101ACVR1B0.51261842
102ERBB40.49972934
103TRPM70.49661976
104MAPK150.48850281
105CAMK1D0.48784213
106PRKCZ0.48672225
107RPS6KA30.46684547
108EPHA30.46373294
109RIPK40.46031501
110WNK40.45621018
111CSNK1G30.45324795
112CDK30.45266501
113CSNK1A10.43387825
114PRKAA10.42642663
115RPS6KA20.42492013
116TNK20.42338677
117PRKG10.42321642
118PRKCB0.42144774
119CAMK40.41601283
120PRKCH0.41600233
121CSNK1E0.41561737
122ROCK10.40416444
123PRKACA0.40329391
124PRKACB0.40321273
125ADRBK10.39066799
126SGK30.38509084
127ERBB20.38506949
128FYN0.38471166
129LIMK10.37911089
130INSRR0.37686074
131TAOK10.37500803
132STK240.37288364
133RAF10.37279960
134CAMK2G0.35221019
135ADRBK20.34677887
136MAP3K20.33741842
137PRKCA0.29970937
138WNK10.28921298

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.76988119
2Synaptic vesicle cycle_Homo sapiens_hsa047213.91311213
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.41185602
4GABAergic synapse_Homo sapiens_hsa047273.19820090
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.16552486
6Morphine addiction_Homo sapiens_hsa050322.99285111
7Circadian entrainment_Homo sapiens_hsa047132.75915485
8Collecting duct acid secretion_Homo sapiens_hsa049662.61954049
9Olfactory transduction_Homo sapiens_hsa047402.58767676
10Glutamatergic synapse_Homo sapiens_hsa047242.46235231
11Amphetamine addiction_Homo sapiens_hsa050312.22079181
12Dopaminergic synapse_Homo sapiens_hsa047282.17444625
13Long-term potentiation_Homo sapiens_hsa047202.13285361
14Serotonergic synapse_Homo sapiens_hsa047262.08642594
15Salivary secretion_Homo sapiens_hsa049701.91058857
16Insulin secretion_Homo sapiens_hsa049111.86740857
17Renin secretion_Homo sapiens_hsa049241.86721371
18Protein export_Homo sapiens_hsa030601.86303855
19Taste transduction_Homo sapiens_hsa047421.86201700
20Cholinergic synapse_Homo sapiens_hsa047251.85056632
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83709020
22Cocaine addiction_Homo sapiens_hsa050301.71204021
23Long-term depression_Homo sapiens_hsa047301.64979871
24Calcium signaling pathway_Homo sapiens_hsa040201.64912175
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63098688
26Vibrio cholerae infection_Homo sapiens_hsa051101.59766648
27Oxytocin signaling pathway_Homo sapiens_hsa049211.56284309
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52327588
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40020315
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35804494
31Cardiac muscle contraction_Homo sapiens_hsa042601.34217231
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33959908
33Oxidative phosphorylation_Homo sapiens_hsa001901.28777661
34Gap junction_Homo sapiens_hsa045401.26721910
35Regulation of autophagy_Homo sapiens_hsa041401.24373203
36Axon guidance_Homo sapiens_hsa043601.21927087
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20550302
38Gastric acid secretion_Homo sapiens_hsa049711.20503456
39Ether lipid metabolism_Homo sapiens_hsa005651.19249610
40Phototransduction_Homo sapiens_hsa047441.17734855
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16074783
42Circadian rhythm_Homo sapiens_hsa047101.06764149
43cAMP signaling pathway_Homo sapiens_hsa040241.06444392
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05768384
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04088446
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03086281
47GnRH signaling pathway_Homo sapiens_hsa049121.00587868
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98107406
49Selenocompound metabolism_Homo sapiens_hsa004500.98102675
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95907447
51Alzheimers disease_Homo sapiens_hsa050100.95759967
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95056025
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93136322
54Parkinsons disease_Homo sapiens_hsa050120.92466763
55Fatty acid elongation_Homo sapiens_hsa000620.92262895
56Vitamin B6 metabolism_Homo sapiens_hsa007500.90184650
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88251820
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.87224795
59Type II diabetes mellitus_Homo sapiens_hsa049300.86435688
60Dilated cardiomyopathy_Homo sapiens_hsa054140.84144641
61Tryptophan metabolism_Homo sapiens_hsa003800.82910694
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81435491
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80852211
64Estrogen signaling pathway_Homo sapiens_hsa049150.80310846
65ErbB signaling pathway_Homo sapiens_hsa040120.78480725
66ABC transporters_Homo sapiens_hsa020100.78251875
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78193516
68Propanoate metabolism_Homo sapiens_hsa006400.74881401
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74809216
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74242087
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73733309
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72254590
73Linoleic acid metabolism_Homo sapiens_hsa005910.69531244
74Hedgehog signaling pathway_Homo sapiens_hsa043400.68585379
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.67594332
76Rheumatoid arthritis_Homo sapiens_hsa053230.66717943
77Fatty acid metabolism_Homo sapiens_hsa012120.66545621
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66159633
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65717133
80Melanogenesis_Homo sapiens_hsa049160.62311171
81Alcoholism_Homo sapiens_hsa050340.61693979
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61335802
83Glioma_Homo sapiens_hsa052140.60778863
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60607983
85MAPK signaling pathway_Homo sapiens_hsa040100.58601195
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56893844
87Oocyte meiosis_Homo sapiens_hsa041140.54155095
88Huntingtons disease_Homo sapiens_hsa050160.52477289
89Glucagon signaling pathway_Homo sapiens_hsa049220.50700172
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.50356833
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50082689
92Pancreatic secretion_Homo sapiens_hsa049720.49664261
93Basal transcription factors_Homo sapiens_hsa030220.49279208
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.47698905
95beta-Alanine metabolism_Homo sapiens_hsa004100.46237991
96Bile secretion_Homo sapiens_hsa049760.45891628
97Steroid biosynthesis_Homo sapiens_hsa001000.45659119
98Fructose and mannose metabolism_Homo sapiens_hsa000510.45285345
99Ras signaling pathway_Homo sapiens_hsa040140.45271787
100Phagosome_Homo sapiens_hsa041450.42983614
101Inositol phosphate metabolism_Homo sapiens_hsa005620.40472448
102Choline metabolism in cancer_Homo sapiens_hsa052310.40376457
103Butanoate metabolism_Homo sapiens_hsa006500.39956857
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39797414
105Thyroid hormone synthesis_Homo sapiens_hsa049180.39592573
106Nitrogen metabolism_Homo sapiens_hsa009100.39562508
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38940689
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38649461
109Peroxisome_Homo sapiens_hsa041460.38354980
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37584239
111Type I diabetes mellitus_Homo sapiens_hsa049400.36513493
112Ovarian steroidogenesis_Homo sapiens_hsa049130.36477076
113Renal cell carcinoma_Homo sapiens_hsa052110.35677489
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31823205
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31479389
116Endometrial cancer_Homo sapiens_hsa052130.31298154
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30292353
118Wnt signaling pathway_Homo sapiens_hsa043100.28622129
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.28529334
120Rap1 signaling pathway_Homo sapiens_hsa040150.28353930
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28010190
122Colorectal cancer_Homo sapiens_hsa052100.27507100
123Pyruvate metabolism_Homo sapiens_hsa006200.26807271
124Insulin signaling pathway_Homo sapiens_hsa049100.25956090
125Dorso-ventral axis formation_Homo sapiens_hsa043200.20872950
126Mineral absorption_Homo sapiens_hsa049780.20091442
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19723098
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19681118
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18542867
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18521926

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