CNTN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)6.04251877
2vocalization behavior (GO:0071625)5.56676620
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34011691
4* neuron cell-cell adhesion (GO:0007158)5.08601322
5synaptic vesicle exocytosis (GO:0016079)5.00473916
6regulation of synaptic vesicle exocytosis (GO:2000300)4.68353904
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.62007567
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58557687
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.53688216
10glutamate secretion (GO:0014047)4.53234126
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.52389320
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.46011601
13regulation of glutamate receptor signaling pathway (GO:1900449)4.40107069
14protein localization to synapse (GO:0035418)4.37081960
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.33125939
16G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.00747705
17regulation of synaptic vesicle transport (GO:1902803)3.98455077
18synaptic vesicle maturation (GO:0016188)3.97008891
19neurotransmitter secretion (GO:0007269)3.95672117
20locomotory exploration behavior (GO:0035641)3.95534674
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95530438
22glutamate receptor signaling pathway (GO:0007215)3.94815159
23behavioral response to cocaine (GO:0048148)3.94770766
24neurotransmitter-gated ion channel clustering (GO:0072578)3.91864257
25neuron-neuron synaptic transmission (GO:0007270)3.90128183
26protein localization to cilium (GO:0061512)3.89510026
27sensory perception of chemical stimulus (GO:0007606)3.87645697
28endocrine pancreas development (GO:0031018)3.81129107
29neuronal action potential propagation (GO:0019227)3.81096821
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.80751487
31presynaptic membrane assembly (GO:0097105)3.78454495
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.75402635
33cellular ketone body metabolic process (GO:0046950)3.75305337
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.74390942
35regulation of synapse structural plasticity (GO:0051823)3.73460522
36synaptic transmission, glutamatergic (GO:0035249)3.69350907
37mating behavior (GO:0007617)3.68060378
38* neuron recognition (GO:0008038)3.66292681
39long-term synaptic potentiation (GO:0060291)3.63095737
40insulin secretion (GO:0030073)3.61516513
41striatum development (GO:0021756)3.58881552
42cerebellar Purkinje cell differentiation (GO:0021702)3.55410116
43positive regulation of synapse maturation (GO:0090129)3.52957927
44postsynaptic membrane organization (GO:0001941)3.48793251
45inositol phosphate catabolic process (GO:0071545)3.44821542
46presynaptic membrane organization (GO:0097090)3.43573513
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.42728578
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42217767
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.41572296
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.39203699
51synaptic vesicle endocytosis (GO:0048488)3.38158050
52membrane depolarization during action potential (GO:0086010)3.37457883
53regulation of neuronal synaptic plasticity (GO:0048168)3.36788137
54response to histamine (GO:0034776)3.36483392
55exploration behavior (GO:0035640)3.36183969
56neuron fate determination (GO:0048664)3.36175998
57regulation of female receptivity (GO:0045924)3.34414000
58neurotransmitter transport (GO:0006836)3.33890338
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33402411
60transmission of nerve impulse (GO:0019226)3.33201044
61synapse assembly (GO:0007416)3.32310735
62ketone body metabolic process (GO:1902224)3.32188335
63epithelial cell fate commitment (GO:0072148)3.31703780
64regulation of postsynaptic membrane potential (GO:0060078)3.29201699
65detection of calcium ion (GO:0005513)3.28625346
66membrane hyperpolarization (GO:0060081)3.28159416
67regulation of hexokinase activity (GO:1903299)3.26804193
68regulation of glucokinase activity (GO:0033131)3.26804193
69female mating behavior (GO:0060180)3.26509558
70auditory behavior (GO:0031223)3.25315137
71gamma-aminobutyric acid transport (GO:0015812)3.24110403
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.22884114
73positive regulation of neurotransmitter transport (GO:0051590)3.22555085
74regulation of neurotransmitter secretion (GO:0046928)3.22168646
75phosphorylated carbohydrate dephosphorylation (GO:0046838)3.22093193
76inositol phosphate dephosphorylation (GO:0046855)3.22093193
77startle response (GO:0001964)3.16746419
78positive regulation of membrane potential (GO:0045838)3.13650086
79layer formation in cerebral cortex (GO:0021819)3.12013428
80activation of protein kinase A activity (GO:0034199)3.11934587
81glycerophospholipid catabolic process (GO:0046475)3.09305682
82* axonal fasciculation (GO:0007413)3.07929571
83negative regulation of dendrite morphogenesis (GO:0050774)3.07815437
84epithelial cilium movement (GO:0003351)3.06602391
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04856866
86* regulation of synaptic plasticity (GO:0048167)3.04333802
87proline transport (GO:0015824)3.03992722
88negative regulation of cytosolic calcium ion concentration (GO:0051481)3.03524528
89cellular potassium ion homeostasis (GO:0030007)3.02492949
90membrane depolarization (GO:0051899)3.01670509
91long-term memory (GO:0007616)3.01368886
92innervation (GO:0060384)2.99589313
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99510245
94positive regulation of neurotransmitter secretion (GO:0001956)2.98699567
95regulation of neurotransmitter transport (GO:0051588)2.98468579
96response to auditory stimulus (GO:0010996)2.98348045
97regulation of neurotransmitter levels (GO:0001505)2.97944260
98synaptic transmission (GO:0007268)2.97816742
99nephron tubule morphogenesis (GO:0072078)2.96416981
100nephron epithelium morphogenesis (GO:0072088)2.96416981
101mechanosensory behavior (GO:0007638)2.95682564
102regulation of synapse maturation (GO:0090128)2.95318480
103positive regulation of synapse assembly (GO:0051965)2.93330399
104regulation of type B pancreatic cell apoptotic process (GO:2000674)2.93044015
105regulation of synaptic transmission, GABAergic (GO:0032228)2.91844174
106nucleobase catabolic process (GO:0046113)2.91290239
107protein insertion into membrane (GO:0051205)2.90786701
108positive regulation of insulin secretion (GO:0032024)2.89432762
109response to cocaine (GO:0042220)2.88420906
110dendrite morphogenesis (GO:0048813)2.87956733
111prepulse inhibition (GO:0060134)2.87206639
112dopamine receptor signaling pathway (GO:0007212)2.85996567
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84492241
114regulation of respiratory system process (GO:0044065)2.84248657
115auditory receptor cell differentiation (GO:0042491)2.84235317
116regulation of protein kinase A signaling (GO:0010738)2.83923757
117dendritic spine morphogenesis (GO:0060997)2.83365956
118transferrin transport (GO:0033572)2.83306096
119cerebellar granule cell differentiation (GO:0021707)2.83140414
120type B pancreatic cell development (GO:0003323)2.83116679
121alanine transport (GO:0032328)2.82897489
122renal tubule morphogenesis (GO:0061333)2.81461209
123regulation of calcium ion-dependent exocytosis (GO:0017158)2.80251793
124positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.79672808
125protein targeting to Golgi (GO:0000042)2.78003047
126pyrimidine nucleobase catabolic process (GO:0006208)2.76648953
127protein polyglutamylation (GO:0018095)2.75602048
128establishment of protein localization to Golgi (GO:0072600)2.73319101
129behavioral response to nicotine (GO:0035095)2.72252018
130retinal ganglion cell axon guidance (GO:0031290)2.71268716
131nonmotile primary cilium assembly (GO:0035058)2.71063963
132neuronal action potential (GO:0019228)2.68067839
133nitric oxide mediated signal transduction (GO:0007263)2.67357118
134kidney morphogenesis (GO:0060993)2.67171445
135peptide hormone processing (GO:0016486)2.62874123
136polyol catabolic process (GO:0046174)2.61765219
137positive regulation of peptide hormone secretion (GO:0090277)2.60297481
138serotonin metabolic process (GO:0042428)2.60242514
139positive regulation of glycolytic process (GO:0045821)2.59600456
140urinary tract smooth muscle contraction (GO:0014848)2.55800084
141somite rostral/caudal axis specification (GO:0032525)2.55208885
142positive regulation of meiosis (GO:0045836)2.55196523
143positive regulation of peptide secretion (GO:0002793)2.54118430
144peptide hormone secretion (GO:0030072)2.53284460
145retrograde transport, vesicle recycling within Golgi (GO:0000301)2.52963279
146establishment of nucleus localization (GO:0040023)2.51794070
147cochlea development (GO:0090102)2.49669816
148positive regulation of action potential (GO:0045760)2.48239259
149calcium ion-dependent exocytosis (GO:0017156)2.45707351
150negative regulation of dendrite development (GO:2000171)2.45680490
151regulation of action potential (GO:0098900)2.45355212
152peptide secretion (GO:0002790)2.44772336
153cilium movement (GO:0003341)2.44570676
154chemosensory behavior (GO:0007635)2.42335550
155dentate gyrus development (GO:0021542)2.41926444
156retinal cone cell development (GO:0046549)2.41916747
157regulation of neurotransmitter uptake (GO:0051580)2.40296951
158negative regulation of execution phase of apoptosis (GO:1900118)2.40131326
159intra-Golgi vesicle-mediated transport (GO:0006891)2.40098643
160protein localization to Golgi apparatus (GO:0034067)2.38456630
161negative regulation of hormone biosynthetic process (GO:0032353)2.38209057
162primary amino compound metabolic process (GO:1901160)2.37550710
163positive regulation of meiotic cell cycle (GO:0051446)2.37232747
164regulation of insulin secretion (GO:0050796)2.36340965
165dopamine biosynthetic process (GO:0042416)2.35583392
166macroautophagy (GO:0016236)2.34985126
167reflex (GO:0060004)2.32372360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.50764516
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.55611883
3* GBX2_23144817_ChIP-Seq_PC3_Human4.09546543
4TAF15_26573619_Chip-Seq_HEK293_Human2.86513706
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80669805
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79851273
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66656801
8REST_21632747_ChIP-Seq_MESCs_Mouse2.44943056
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38787811
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38787811
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36827113
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.31895433
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31640919
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30498497
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24764897
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18960971
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18642434
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.18640433
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16506509
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15599720
21DROSHA_22980978_ChIP-Seq_HELA_Human2.13198272
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13074225
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04223230
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95888139
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.94885977
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.93502773
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.93062446
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.92394959
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89607872
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88309957
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86115625
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83850621
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.83545248
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83475686
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83317101
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82466212
37* P300_19829295_ChIP-Seq_ESCs_Human1.79195108
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71819037
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67872902
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64519386
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59626093
42AR_21572438_ChIP-Seq_LNCaP_Human1.56489160
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.56137755
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.53905948
45* RNF2_27304074_Chip-Seq_NSC_Mouse1.48325625
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.48277633
47FUS_26573619_Chip-Seq_HEK293_Human1.46849917
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.45398253
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44810043
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43498621
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.41690511
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38974620
53EWS_26573619_Chip-Seq_HEK293_Human1.37815131
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36867624
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35360697
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35251314
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34213795
58AHR_22903824_ChIP-Seq_MCF-7_Human1.34135248
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33798009
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.33713804
61IGF1R_20145208_ChIP-Seq_DFB_Human1.32840740
62AR_25329375_ChIP-Seq_VCAP_Human1.32798564
63* STAT3_23295773_ChIP-Seq_U87_Human1.32547432
64ZNF274_21170338_ChIP-Seq_K562_Hela1.31596575
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29994124
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28672046
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28143860
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26099210
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25103354
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25103354
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24571063
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23541362
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23177923
74RUNX2_22187159_ChIP-Seq_PCA_Human1.22705061
75* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22486333
76* TCF4_23295773_ChIP-Seq_U87_Human1.22418064
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21923290
78ER_23166858_ChIP-Seq_MCF-7_Human1.21652224
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21431021
80P53_22387025_ChIP-Seq_ESCs_Mouse1.20886456
81HTT_18923047_ChIP-ChIP_STHdh_Human1.20727938
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20698235
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.20637710
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20015432
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15879524
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15284092
87* TAL1_26923725_Chip-Seq_HPCs_Mouse1.15145116
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14098400
89JUN_21703547_ChIP-Seq_K562_Human1.13529617
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.11731973
91* AR_19668381_ChIP-Seq_PC3_Human1.11727479
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11150484
93* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08773923
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.08466964
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07382609
96BCAT_22108803_ChIP-Seq_LS180_Human1.07153732
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.06647175
98VDR_22108803_ChIP-Seq_LS180_Human1.06434483
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06419773
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.06126462
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04859718
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04787732
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03640222
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.03586970
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03321537
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02541591
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01815508
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01781589
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.01344611
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00583654
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99161282
112TP53_18474530_ChIP-ChIP_U2OS_Human0.98309414
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97480465
114SOX9_26525672_Chip-Seq_HEART_Mouse0.97062843
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.95958849
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95581892
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95059628
118* KDM2B_26808549_Chip-Seq_REH_Human0.93810712
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93195795
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91460256
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91219761
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.90877974
123CBP_20019798_ChIP-Seq_JUKART_Human0.90331481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.27066993
2MP0003880_abnormal_central_pattern4.56132689
3MP0004859_abnormal_synaptic_plasticity4.51915595
4MP0002822_catalepsy4.36897823
5MP0003635_abnormal_synaptic_transmissio3.64838291
6MP0004270_analgesia3.11218534
7MP0009745_abnormal_behavioral_response3.03055859
8MP0002063_abnormal_learning/memory/cond2.96488234
9MP0002064_seizures2.95301098
10MP0005423_abnormal_somatic_nervous2.84603089
11MP0009046_muscle_twitch2.75269604
12MP0002572_abnormal_emotion/affect_behav2.65406697
13MP0001486_abnormal_startle_reflex2.64495842
14MP0002272_abnormal_nervous_system2.60312213
15MP0002734_abnormal_mechanical_nocicepti2.56744177
16MP0005379_endocrine/exocrine_gland_phen2.54020654
17MP0001968_abnormal_touch/_nociception2.52093682
18MP0003283_abnormal_digestive_organ2.28473509
19MP0008877_abnormal_DNA_methylation2.26891627
20MP0005499_abnormal_olfactory_system2.20439636
21MP0005394_taste/olfaction_phenotype2.20439636
22MP0002735_abnormal_chemical_nociception2.18190781
23MP0002184_abnormal_innervation2.13724059
24MP0006276_abnormal_autonomic_nervous2.07979585
25MP0001501_abnormal_sleep_pattern2.05824020
26MP0002067_abnormal_sensory_capabilities1.97490983
27MP0002736_abnormal_nociception_after1.96998708
28MP0008789_abnormal_olfactory_epithelium1.95534858
29MP0005646_abnormal_pituitary_gland1.92176690
30MP0002557_abnormal_social/conspecific_i1.86813381
31MP0005551_abnormal_eye_electrophysiolog1.81014326
32MP0001944_abnormal_pancreas_morphology1.80652699
33MP0000778_abnormal_nervous_system1.78338015
34MP0005645_abnormal_hypothalamus_physiol1.77569042
35MP0001970_abnormal_pain_threshold1.77123896
36MP0001529_abnormal_vocalization1.74739866
37MP0002163_abnormal_gland_morphology1.73855171
38MP0001188_hyperpigmentation1.73186228
39MP0002733_abnormal_thermal_nociception1.68639736
40MP0004133_heterotaxia1.66439863
41MP0001440_abnormal_grooming_behavior1.61219064
42MP0004924_abnormal_behavior1.60172726
43MP0005386_behavior/neurological_phenoty1.60172726
44MP0002882_abnormal_neuron_morphology1.53005264
45MP0003879_abnormal_hair_cell1.52399637
46MP0004742_abnormal_vestibular_system1.51686497
47MP0004811_abnormal_neuron_physiology1.49960645
48MP0003195_calcinosis1.46650980
49MP0002693_abnormal_pancreas_physiology1.46489538
50MP0003787_abnormal_imprinting1.46479405
51MP0001502_abnormal_circadian_rhythm1.44969918
52MP0008569_lethality_at_weaning1.44043392
53MP0002928_abnormal_bile_duct1.39200218
54MP0001485_abnormal_pinna_reflex1.38064974
55MP0005084_abnormal_gallbladder_morpholo1.28631721
56MP0002066_abnormal_motor_capabilities/c1.26212820
57MP0009780_abnormal_chondrocyte_physiolo1.23093138
58MP0003136_yellow_coat_color1.22935600
59MP0002909_abnormal_adrenal_gland1.22252446
60MP0003329_amyloid_beta_deposits1.19951396
61MP0003123_paternal_imprinting1.19753614
62MP0002837_dystrophic_cardiac_calcinosis1.17030541
63MP0004043_abnormal_pH_regulation1.16252996
64MP0001905_abnormal_dopamine_level1.15982101
65MP0004885_abnormal_endolymph1.15930339
66MP0000955_abnormal_spinal_cord1.14603550
67MP0003122_maternal_imprinting1.14149573
68MP0002938_white_spotting1.12967676
69* MP0002752_abnormal_somatic_nervous1.12780202
70MP0001963_abnormal_hearing_physiology1.12694296
71MP0002152_abnormal_brain_morphology1.12342141
72MP0004142_abnormal_muscle_tone1.11964563
73MP0003011_delayed_dark_adaptation1.11326691
74MP0002229_neurodegeneration1.11018643
75MP0005220_abnormal_exocrine_pancreas1.10813365
76MP0002876_abnormal_thyroid_physiology1.09913828
77MP0000427_abnormal_hair_cycle1.07509187
78MP0002078_abnormal_glucose_homeostasis1.05471931
79MP0004858_abnormal_nervous_system1.04748074
80MP0004019_abnormal_vitamin_homeostasis1.02984274
81MP0000631_abnormal_neuroendocrine_gland1.02620212
82MP0001756_abnormal_urination1.01860949
83MP0002139_abnormal_hepatobiliary_system1.01115321
84MP0010386_abnormal_urinary_bladder0.99613271
85MP0005248_abnormal_Harderian_gland0.98288601
86MP0002090_abnormal_vision0.93922220
87MP0003633_abnormal_nervous_system0.93899823
88MP0002653_abnormal_ependyma_morphology0.92305394
89MP0010329_abnormal_lipoprotein_level0.91015499
90MP0001986_abnormal_taste_sensitivity0.90420909
91MP0003890_abnormal_embryonic-extraembry0.87038562
92MP0006072_abnormal_retinal_apoptosis0.86610959
93MP0003631_nervous_system_phenotype0.86161729
94MP0002102_abnormal_ear_morphology0.85007875
95MP0000751_myopathy0.84614661
96MP0005171_absent_coat_pigmentation0.83800451
97MP0005448_abnormal_energy_balance0.83033515
98MP0000026_abnormal_inner_ear0.81977507
99MP0002069_abnormal_eating/drinking_beha0.81970343
100MP0004085_abnormal_heartbeat0.80835574
101MP0000516_abnormal_urinary_system0.79940034
102MP0005367_renal/urinary_system_phenotyp0.79940034
103MP0010234_abnormal_vibrissa_follicle0.79933135
104MP0003953_abnormal_hormone_level0.78788863
105MP0005174_abnormal_tail_pigmentation0.78095735
106MP0004215_abnormal_myocardial_fiber0.75933639
107MP0008874_decreased_physiological_sensi0.73310081
108MP0002638_abnormal_pupillary_reflex0.73027462
109MP0003634_abnormal_glial_cell0.72100978
110MP0005253_abnormal_eye_physiology0.71145520
111MP0004145_abnormal_muscle_electrophysio0.70090251
112MP0001177_atelectasis0.69506380
113MP0005187_abnormal_penis_morphology0.67891585
114MP0008872_abnormal_physiological_respon0.67642324
115MP0001664_abnormal_digestion0.66528686
116MP0005195_abnormal_posterior_eye0.65077654
117MP0004484_altered_response_of0.63365942
118MP0002160_abnormal_reproductive_system0.62497202
119MP0003861_abnormal_nervous_system0.62304904
120MP0003632_abnormal_nervous_system0.59881754
121MP0000013_abnormal_adipose_tissue0.57687255
122MP0001943_abnormal_respiration0.56891737
123MP0003121_genomic_imprinting0.54680576
124MP0000569_abnormal_digit_pigmentation0.54538495
125MP0005535_abnormal_body_temperature0.54203129
126MP0010770_preweaning_lethality0.53240256
127MP0002082_postnatal_lethality0.53240256
128MP0005410_abnormal_fertilization0.50211616
129MP0002751_abnormal_autonomic_nervous0.49806159
130MP0005409_darkened_coat_color0.49694438
131MP0010769_abnormal_survival0.49017567

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.98504552
2Atonic seizures (HP:0010819)6.29936278
3Febrile seizures (HP:0002373)5.94957786
4Focal seizures (HP:0007359)5.42244224
5Absence seizures (HP:0002121)4.89900036
6Hyperventilation (HP:0002883)4.80079080
7Myokymia (HP:0002411)4.75460767
8Epileptic encephalopathy (HP:0200134)4.70662298
9Dialeptic seizures (HP:0011146)4.43415546
10Visual hallucinations (HP:0002367)3.94283720
11Generalized tonic-clonic seizures (HP:0002069)3.86722869
12Progressive cerebellar ataxia (HP:0002073)3.86216092
13Gait imbalance (HP:0002141)3.68781893
14Abnormality of macular pigmentation (HP:0008002)3.68751073
15Intestinal atresia (HP:0011100)3.51510329
16Medial flaring of the eyebrow (HP:0010747)3.39375646
17Congenital primary aphakia (HP:0007707)3.39250134
18Broad-based gait (HP:0002136)3.37035526
19Hypoglycemic coma (HP:0001325)3.34456844
20Hypoglycemic seizures (HP:0002173)3.31087838
21Nephrogenic diabetes insipidus (HP:0009806)3.24372307
22Gaze-evoked nystagmus (HP:0000640)3.20630018
23Limb dystonia (HP:0002451)3.15466424
24Truncal ataxia (HP:0002078)3.12630324
25Ketoacidosis (HP:0001993)3.11031787
26Pancreatic cysts (HP:0001737)3.07237864
27Hyperinsulinemic hypoglycemia (HP:0000825)3.05283974
28Ankle clonus (HP:0011448)2.93273427
29Type II lissencephaly (HP:0007260)2.91258034
30Large for gestational age (HP:0001520)2.88109596
31Hypothermia (HP:0002045)2.83041104
32Nephronophthisis (HP:0000090)2.81114940
33Hyperglycemia (HP:0003074)2.78024346
34Excessive salivation (HP:0003781)2.71486366
35Drooling (HP:0002307)2.71486366
36Central scotoma (HP:0000603)2.70443326
37Genital tract atresia (HP:0001827)2.68111414
38Retinal dysplasia (HP:0007973)2.66641344
39Impaired vibration sensation in the lower limbs (HP:0002166)2.66174748
40Congenital stationary night blindness (HP:0007642)2.66088703
41Poor coordination (HP:0002370)2.63590099
42Agitation (HP:0000713)2.62839550
43Amblyopia (HP:0000646)2.61441375
44Action tremor (HP:0002345)2.59449542
45Vaginal atresia (HP:0000148)2.59408983
46Absent speech (HP:0001344)2.58871987
47Urinary bladder sphincter dysfunction (HP:0002839)2.55701030
48Dysdiadochokinesis (HP:0002075)2.55669523
49Abnormality of midbrain morphology (HP:0002418)2.53670028
50Molar tooth sign on MRI (HP:0002419)2.53670028
51Abnormal respiratory motile cilium physiology (HP:0012261)2.53217407
52Protruding tongue (HP:0010808)2.51332664
53Enlarged penis (HP:0000040)2.49906580
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49251534
55Abnormal hair whorl (HP:0010721)2.43793697
56Genetic anticipation (HP:0003743)2.42013800
57Specific learning disability (HP:0001328)2.41087451
58Impaired social interactions (HP:0000735)2.39608293
59Abnormal social behavior (HP:0012433)2.39608293
60Pancreatic fibrosis (HP:0100732)2.39174005
61Poor eye contact (HP:0000817)2.38291511
62Abnormal ciliary motility (HP:0012262)2.37475157
63Anxiety (HP:0000739)2.35181119
64Abnormality of the renal cortex (HP:0011035)2.34921332
65Abnormality of vitamin B metabolism (HP:0004340)2.32411099
66Abnormality of the renal medulla (HP:0100957)2.31850203
67Pheochromocytoma (HP:0002666)2.30089913
68Gastrointestinal atresia (HP:0002589)2.29223101
69Epileptiform EEG discharges (HP:0011182)2.29015161
70Abnormal pancreas size (HP:0012094)2.25676898
71Double outlet right ventricle (HP:0001719)2.23769981
72Congenital malformation of the right heart (HP:0011723)2.23769981
73Progressive inability to walk (HP:0002505)2.22992711
74Dysmetria (HP:0001310)2.21903647
75Congenital sensorineural hearing impairment (HP:0008527)2.20651951
76Abnormality of the labia minora (HP:0012880)2.19814565
77Depression (HP:0000716)2.19713144
78Renal cortical cysts (HP:0000803)2.18059825
79Torticollis (HP:0000473)2.17848507
80Abnormality of salivation (HP:0100755)2.17795768
81EEG with generalized epileptiform discharges (HP:0011198)2.16414304
82Postural tremor (HP:0002174)2.14633765
83Blue irides (HP:0000635)2.13139091
84Hepatoblastoma (HP:0002884)2.12882844
85Abnormal eating behavior (HP:0100738)2.12701891
86Ketosis (HP:0001946)2.11436628
87Abnormal rod and cone electroretinograms (HP:0008323)2.10373791
88Impaired smooth pursuit (HP:0007772)2.10103743
89Acute necrotizing encephalopathy (HP:0006965)2.10032835
90Hypomagnesemia (HP:0002917)2.09447735
91Neuroendocrine neoplasm (HP:0100634)2.09213577
92Polydipsia (HP:0001959)2.08944784
93Abnormal drinking behavior (HP:0030082)2.08944784
94Termporal pattern (HP:0011008)2.08839543
95Insidious onset (HP:0003587)2.08839543
96Optic nerve hypoplasia (HP:0000609)2.08573679
97Impaired vibratory sensation (HP:0002495)2.08304800
98Scanning speech (HP:0002168)2.07431161
99Supranuclear gaze palsy (HP:0000605)2.06690973
100Aplasia/Hypoplasia of the lens (HP:0008063)2.05986203
101Spastic gait (HP:0002064)2.05539065
102Dynein arm defect of respiratory motile cilia (HP:0012255)2.04435408
103Absent/shortened dynein arms (HP:0200106)2.04435408
104Fetal akinesia sequence (HP:0001989)2.03970270
105Cystic liver disease (HP:0006706)2.03699535
106Dysmetric saccades (HP:0000641)2.03258296
107Chronic hepatic failure (HP:0100626)2.01812474
108Muscular hypotonia of the trunk (HP:0008936)2.01469062
109Increased circulating renin level (HP:0000848)2.01410202
110Progressive macrocephaly (HP:0004481)2.01186951
111Bony spicule pigmentary retinopathy (HP:0007737)1.98528113
112Abnormality of binocular vision (HP:0011514)1.98519153
113Diplopia (HP:0000651)1.98519153
114Furrowed tongue (HP:0000221)1.98322537
115Inability to walk (HP:0002540)1.98188977
116Focal dystonia (HP:0004373)1.97190767
117Hypsarrhythmia (HP:0002521)1.97158160
118Hemiparesis (HP:0001269)1.96741590
119Abnormality of the corticospinal tract (HP:0002492)1.96620685
120Symptomatic seizures (HP:0011145)1.96387161
121Abnormal mitochondria in muscle tissue (HP:0008316)1.96266921
122Neoplasm of the adrenal cortex (HP:0100641)1.94548527
123Severe visual impairment (HP:0001141)1.94138516
124Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93644112
125Cerebellar dysplasia (HP:0007033)1.93449644
126Methylmalonic acidemia (HP:0002912)1.92997221
127Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91730207
128Postural instability (HP:0002172)1.91107734
129Lissencephaly (HP:0001339)1.91010577
130Tubular atrophy (HP:0000092)1.90831914
131Generalized myoclonic seizures (HP:0002123)1.89331397
132Metaphyseal dysplasia (HP:0100255)1.89204899
133Urethral obstruction (HP:0000796)1.88740456
134Abnormal respiratory epithelium morphology (HP:0012253)1.88468443
135Abnormal respiratory motile cilium morphology (HP:0005938)1.88468443
136Urinary urgency (HP:0000012)1.87339277
137Craniofacial dystonia (HP:0012179)1.87208012
138True hermaphroditism (HP:0010459)1.86925466
139Polyphagia (HP:0002591)1.86533279
140Hyperthyroidism (HP:0000836)1.83079318
141Aqueductal stenosis (HP:0002410)1.82727610
142Attenuation of retinal blood vessels (HP:0007843)1.82406503
143Poor suck (HP:0002033)1.82366353
144Abnormality of ocular smooth pursuit (HP:0000617)1.81775233
145Male pseudohermaphroditism (HP:0000037)1.81715431
146Abnormality of the pancreatic islet cells (HP:0006476)1.80783491
147Abnormality of endocrine pancreas physiology (HP:0012093)1.80783491
148Bradykinesia (HP:0002067)1.80350407
149Insulin-resistant diabetes mellitus (HP:0000831)1.79019827
150Anosmia (HP:0000458)1.78865945
151Abnormality of vitamin metabolism (HP:0100508)1.78157927
152Prolonged QT interval (HP:0001657)1.77584260
153Scotoma (HP:0000575)1.77314479
154Intention tremor (HP:0002080)1.75476042
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74593633
156Pachygyria (HP:0001302)1.73364132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.82864739
2CASK4.29832695
3NTRK33.74758277
4MAP2K73.42786805
5MAP3K43.41583963
6EPHA43.13970801
7FGFR22.94056946
8MARK12.91999623
9MAP3K122.82634364
10NTRK22.54317002
11PINK12.51451027
12MINK12.44614654
13DAPK22.31498717
14MAP4K22.26252873
15MAP2K42.21289251
16PRPF4B2.16112979
17MAP3K92.09343316
18MAPK132.00614146
19PLK21.94727961
20AKT31.76056113
21EPHA31.75876500
22PHKG11.73159843
23PHKG21.73159843
24GRK51.69430552
25BMPR1B1.68380043
26ADRBK21.66743687
27DAPK11.65619134
28RIPK41.64054506
29ARAF1.61146892
30INSRR1.59014951
31TNIK1.57711724
32PAK61.53596674
33GRK11.49088196
34ACVR1B1.48811370
35PRKCG1.37241871
36BMPR21.33499571
37CDK51.29545155
38MST41.29061059
39WNK41.26173710
40CSNK1G11.19530891
41CAMK2B1.19391355
42SGK2231.15613924
43SGK4941.15613924
44SGK21.13181575
45CAMK2A1.12690374
46STK38L1.10624718
47CDK191.09162604
48PNCK1.07245710
49NLK1.06673313
50ERBB31.05779247
51STK381.05743499
52DYRK21.05586579
53PAK31.04294771
54KSR11.04270071
55CAMKK11.01803985
56SIK21.01006594
57NTRK11.00810301
58OXSR10.99871505
59UHMK10.98128740
60CAMKK20.96033641
61STK30.94234750
62DYRK1A0.93250151
63SIK30.92834650
64CAMK2D0.92261004
65BRAF0.87181312
66FGFR30.86909405
67FES0.83330997
68CSNK1G20.83086924
69MAP3K60.79207923
70MAP2K60.73718073
71KSR20.73597116
72CAMK2G0.73185844
73PRKCE0.72965827
74SGK30.71967258
75BCR0.70468092
76MKNK20.69400518
77CDK180.68264164
78MAP3K20.65051435
79STK240.64483819
80PTK2B0.63753696
81CDK140.62824422
82STK110.62306254
83CDK150.61820872
84CSNK1A1L0.59698695
85STK160.59424796
86YES10.56094174
87CSNK1G30.55876405
88SGK10.54444223
89PRKCH0.54439552
90ZAK0.54041788
91PKN10.53333034
92CDK30.52792545
93ADRBK10.52085164
94TAOK10.52051278
95CAMK10.50712107
96TRIM280.50530963
97CDK11A0.50253723
98FGR0.50105756
99LMTK20.49806018
100MUSK0.49570754
101IRAK10.48826918
102TSSK60.48808527
103TYRO30.47717386
104FER0.47475771
105TNK20.46434430
106ROCK20.45510897
107PRKCZ0.45229200
108PRKAA10.44842809
109NME10.44712377
110CSNK1A10.44468863
111CCNB10.44302756
112MAPK150.43746863
113PRKCB0.43498744
114PRKACB0.43322883
115RPS6KA20.43199010
116PDK40.42218361
117PDK30.42218361
118ERBB40.41886706
119RAF10.41713051
120STK390.41126290
121WNK10.40722862
122CSNK1D0.40384609
123PRKD30.39802319
124ROCK10.39748125
125LIMK10.39415615
126RPS6KA30.39201143
127LATS20.39115242
128PRKACA0.38905486
129MAPK100.38603640
130WNK30.38567687
131CDK80.37876052
132MAP2K10.35115489
133PRKG10.35063764
134CAMK1G0.33758132
135PDK10.32079146
136CSNK1E0.31252837
137PASK0.30929858
138PRKCA0.30375458
139PIK3CG0.28889153
140OBSCN0.27525113
141PRKCI0.26765134
142PRKAA20.26420238

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.99752807
2Olfactory transduction_Homo sapiens_hsa047404.83739581
3Nicotine addiction_Homo sapiens_hsa050333.75512575
4Synaptic vesicle cycle_Homo sapiens_hsa047213.46792373
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04372720
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97899127
7GABAergic synapse_Homo sapiens_hsa047272.91770211
8Morphine addiction_Homo sapiens_hsa050322.74318122
9Circadian entrainment_Homo sapiens_hsa047132.65339798
10Glutamatergic synapse_Homo sapiens_hsa047242.51476642
11Collecting duct acid secretion_Homo sapiens_hsa049662.49594817
12Phototransduction_Homo sapiens_hsa047442.30355080
13Dopaminergic synapse_Homo sapiens_hsa047282.26313867
14Amphetamine addiction_Homo sapiens_hsa050312.25927875
15Protein export_Homo sapiens_hsa030602.23566683
16Long-term potentiation_Homo sapiens_hsa047202.22260505
17Taste transduction_Homo sapiens_hsa047422.19708369
18Salivary secretion_Homo sapiens_hsa049701.99483327
19Serotonergic synapse_Homo sapiens_hsa047261.90811976
20Insulin secretion_Homo sapiens_hsa049111.89347252
21Cholinergic synapse_Homo sapiens_hsa047251.80012333
22Vibrio cholerae infection_Homo sapiens_hsa051101.69738031
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68418637
24Gastric acid secretion_Homo sapiens_hsa049711.68290810
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65540670
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62466095
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60576634
28Renin secretion_Homo sapiens_hsa049241.57123551
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53787069
30Long-term depression_Homo sapiens_hsa047301.51090732
31Calcium signaling pathway_Homo sapiens_hsa040201.46410119
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44232614
33Oxytocin signaling pathway_Homo sapiens_hsa049211.38124281
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36325496
35GnRH signaling pathway_Homo sapiens_hsa049121.31634217
36Vitamin B6 metabolism_Homo sapiens_hsa007501.31031428
37Oxidative phosphorylation_Homo sapiens_hsa001901.29912989
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24143491
39Cocaine addiction_Homo sapiens_hsa050301.23065407
40Propanoate metabolism_Homo sapiens_hsa006401.21442905
41Ether lipid metabolism_Homo sapiens_hsa005651.19336656
42Gap junction_Homo sapiens_hsa045401.15143266
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15057334
44cAMP signaling pathway_Homo sapiens_hsa040241.14625378
45Regulation of autophagy_Homo sapiens_hsa041401.14088811
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13561224
47Cardiac muscle contraction_Homo sapiens_hsa042601.09836436
48Sulfur metabolism_Homo sapiens_hsa009201.06722504
49Folate biosynthesis_Homo sapiens_hsa007901.06224613
50Linoleic acid metabolism_Homo sapiens_hsa005911.05841459
51Tryptophan metabolism_Homo sapiens_hsa003801.05695969
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04236271
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03569905
54Alzheimers disease_Homo sapiens_hsa050101.01338062
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98978601
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98501600
57Selenocompound metabolism_Homo sapiens_hsa004500.97056054
58ABC transporters_Homo sapiens_hsa020100.96595525
59Axon guidance_Homo sapiens_hsa043600.95953076
60Parkinsons disease_Homo sapiens_hsa050120.95250593
61Fatty acid elongation_Homo sapiens_hsa000620.94952674
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94821712
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92481483
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87789955
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86954706
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.84626626
67Melanogenesis_Homo sapiens_hsa049160.83765853
68Estrogen signaling pathway_Homo sapiens_hsa049150.82280064
69Glioma_Homo sapiens_hsa052140.81500444
70Nitrogen metabolism_Homo sapiens_hsa009100.78690537
71Steroid biosynthesis_Homo sapiens_hsa001000.78244528
72ErbB signaling pathway_Homo sapiens_hsa040120.77283921
73Peroxisome_Homo sapiens_hsa041460.76724505
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74773818
75Thyroid hormone synthesis_Homo sapiens_hsa049180.74109211
76Oocyte meiosis_Homo sapiens_hsa041140.72577662
77Ovarian steroidogenesis_Homo sapiens_hsa049130.71069928
78beta-Alanine metabolism_Homo sapiens_hsa004100.71031937
79Type II diabetes mellitus_Homo sapiens_hsa049300.70109988
80Alcoholism_Homo sapiens_hsa050340.68257323
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67361857
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67306794
83Pancreatic secretion_Homo sapiens_hsa049720.63660666
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63018133
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62017038
86Fatty acid metabolism_Homo sapiens_hsa012120.61938645
87Dilated cardiomyopathy_Homo sapiens_hsa054140.61798891
88Sphingolipid metabolism_Homo sapiens_hsa006000.61497344
89Huntingtons disease_Homo sapiens_hsa050160.59961414
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58498720
91MAPK signaling pathway_Homo sapiens_hsa040100.58463856
92Ras signaling pathway_Homo sapiens_hsa040140.58176652
93Rheumatoid arthritis_Homo sapiens_hsa053230.56653127
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.55598799
95Retinol metabolism_Homo sapiens_hsa008300.54527517
96Glucagon signaling pathway_Homo sapiens_hsa049220.53057492
97Fatty acid degradation_Homo sapiens_hsa000710.50317978
98Circadian rhythm_Homo sapiens_hsa047100.49426949
99Choline metabolism in cancer_Homo sapiens_hsa052310.45590417
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45443481
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44981053
102Caffeine metabolism_Homo sapiens_hsa002320.43685871
103Type I diabetes mellitus_Homo sapiens_hsa049400.43092781
104Dorso-ventral axis formation_Homo sapiens_hsa043200.42830629
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42678237
106Rap1 signaling pathway_Homo sapiens_hsa040150.41206330
107Fatty acid biosynthesis_Homo sapiens_hsa000610.41190869
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.40643510
109Fat digestion and absorption_Homo sapiens_hsa049750.39693137
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39584249
111Chemical carcinogenesis_Homo sapiens_hsa052040.39209245
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38323030
113Hedgehog signaling pathway_Homo sapiens_hsa043400.37430050
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36803129
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36048493
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35297858
117Inositol phosphate metabolism_Homo sapiens_hsa005620.34470521
118Phagosome_Homo sapiens_hsa041450.33858526
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32502033
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31474343
121Insulin signaling pathway_Homo sapiens_hsa049100.29016142
122Wnt signaling pathway_Homo sapiens_hsa043100.28683514
123African trypanosomiasis_Homo sapiens_hsa051430.28572187
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28124617
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28097982
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.27330512
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27249237
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.26973292
129Bile secretion_Homo sapiens_hsa049760.26151001
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25959023
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23547631
132Butanoate metabolism_Homo sapiens_hsa006500.22709740
133Mineral absorption_Homo sapiens_hsa049780.22563566
134Colorectal cancer_Homo sapiens_hsa052100.22455398
135mTOR signaling pathway_Homo sapiens_hsa041500.21983284
136Endometrial cancer_Homo sapiens_hsa052130.21940579
137Prion diseases_Homo sapiens_hsa050200.21857841
138VEGF signaling pathway_Homo sapiens_hsa043700.21571542

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